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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：O15350 New Search
28PDB entries
48Biological assembly
137chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1COK STRUCTURE OF THE C-TERMINAL DOMAIN OF P73 Deposited 1999-05-28 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 439–506（68 aa） Fragment：C-TERMINAL DOMAIN
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6；298 K；Ionic strength (raw mmCIF value) 150mM NACL, 25mM SODIUM PHOSPHATE
NMR sample composition 10% WATER/90% D2O
Resolution not provided
1DXS Crystal structure of the C-terminal sterile alpha motif (SAM) domain of human p73 alpha splice variant Deposited 2000-01-15 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 487–564（78 aa） Fragment：C-TERMINAL STERILE ALPHA MOTIF (SAM) DOMAIN
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；290 K；CRYSTALLIZED IN 0.1M TRIS-HCL PH8.5, 2.0M MONO-AMMONIUM DIHYDROGEN PHOSPHATE, AT 290K., pH 8.50
Resolution 2.54 Å R-free 0.346
2KBY The Tetramerization Domain of Human p73 Deposited 2008-12-12 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 351–398（48 aa） Fragment：tetramerization domain, UNP residues 351-398
Chain B 351–398（48 aa） Fragment：tetramerization domain, UNP residues 351-398
Chain C 351–398（48 aa） Fragment：tetramerization domain, UNP residues 351-398
Chain D 351–398（48 aa） Fragment：tetramerization domain, UNP residues 351-398
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；303 K；Pressure 1
NMR measurement conditions 303 K；Pressure 1
NMR measurement conditions pH 6.8；303 K；Pressure 1
NMR sample composition 2.5mM [U-13C; U-15N] p73 TD-1, 20mM sodium phosphate-2, 100mM sodium chloride-3, 100% D2O | 100% D2O
NMR sample composition 2.5mM [U-13C; U-15N] p73 TD-4, 20mM sodium phosphate-5, 100mM sodium chloride-6, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 2.5mM [U-15N] p73 TD-7, 20mM sodium phosphate-8, 100mM sodium chloride-9, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 2.5mM [U-15N] p73 TD-10, 2.5mM [U-13C] p73 TD-11, 20mM sodium phosphate-12, 100mM sodium chloride-13, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 2.5mM [U-15N] p73 TD-14, 2.5mM [U-13C] p73 TD-15, 20mM sodium phosphate-16, 100mM sodium chloride-17, 100% D2O | 100% D2O
NMR sample composition 2.5mM [U-10% 13C] p73 TD-18, 20mM sodium phosphate-19, 100mM sodium chloride-20, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 2.5mM [U-13C; U-15N] p73 TD-21, 16.4 Hz Pf1 phage-22, 50mM arginine-23, 50mM glutamate-24, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
2MPS Structure of complex of MDM2(3-109) and P73 TAD(10-25) Deposited 2014-06-02 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 10–25（16 aa） Fragment：UNP residues 10-25
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；283 K；Ionic strength (raw mmCIF value) 50；Pressure ambient
NMR sample composition 0.9 mM [U-99% 13C; U-99% 15N] E3 Ubiquitin-protein Ligase MDM2-1, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.9 mM [U-99% 13C; U-99% 15N] Tumor protein P73-2, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
2NB1 P63/p73 hetero-tetramerisation domain Deposited 2016-01-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain B 351–398（48 aa） Fragment：Tetramerization domain of p73, UNP residues 351-398
Chain D 351–398（48 aa） Fragment：Tetramerization domain of p73, UNP residues 351-398
Mutation：E15K Mutation：E15K No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；310 K；Ionic strength (raw mmCIF value) 75；Pressure ambient
NMR measurement conditions pH 6；310 K；Ionic strength (raw mmCIF value) 5；Pressure ambient
NMR sample composition 0.5 mM [U-100% 13C; U-100% 15N] p63 tetramerization domain, 0.5 mM p73 tetramerization domain, 25 mM HEPES, 50 mM sodium chloride, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.5 mM p63 tetramerization domain, 0.5 mM [U-100% 13C; U-100% 15N] p73 tetramerization domain, 25 mM HEPES, 50 mM sodium chloride, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.5 mM [U-100% 15N] p63 tetramerization domain, 0.5 mM [U-100% 13C] p63 tetramerization domain, 1 mM p73 tetramerization domain, 25 mM HEPES, 50 mM sodium chloride, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 1 mM p63 tetramerization domain, 0.5 mM [U-100% 15N] p73 tetramerization domain, 0.5 mM [U-100% 13C] p73 tetramerization domain, 25 mM HEPES, 50 mM sodium chloride, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.5 mM [U-100% 15N] p63 tetramerization domain, 0.5 mM p73 tetramerization domain, 25 mM HEPES, 50 mM sodium chloride, 100% D2O | 100% D2O
NMR sample composition 0.5 mM p63 tetramerization domain, 0.5 mM [U-100% 15N] p73 tetramerization domain, 25 mM HEPES, 50 mM sodium chloride, 100% D2O | 100% D2O
NMR sample composition 0.5 mM [U-100% 15N] p63 tetramerization domain, 0.5 mM [U-100% 13C] p63 tetramerization domain, 0.5 mM [U-100% 15N] p73 tetramerization domain, 0.5 mM [U-100% 13C] p73 tetramerization domain, 25 mM HEPES, 50 mM sodium chloride, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
2WQI Crystal structure of the human p73 tetramerization domain Deposited 2009-08-21 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Chain B 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Chain C 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Chain D 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.2；290 K；SITTING DROP VAPOR DIFFUSION AT 17 DEGREE C. PROTEIN SOLUTION: 15 MG/ML IN 20 MM TRIS (PH 8.5), 50 MM NACL. CRYSTALLIZATION BUFFER: 0.1 M SODIUM CITRATE (PH 6.2), 40% PEG 600.
Resolution 1.70 Å R-free 0.254
2WQJ Crystal structure of a truncated variant of the human p73 tetramerization domain Deposited 2009-08-21 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain G 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain H 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain I 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain J 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain K 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain L 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；290 K；SITTING DROP VAPOR DIFFUSION AT 17 DEGREE C. PROTEIN SOLUTION: 10 MG/ML IN 20 MM TRIS (PH 8.5), 50 MM NACL. CRYSTALLIZATION BUFFER: 0.1 M TRIS (PH 8.5), 0.9 M AMMONIUM PHOSPHATE.
Resolution 2.00 Å R-free 0.248
2WQJ Crystal structure of a truncated variant of the human p73 tetramerization domain Deposited 2009-08-21 Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain B 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain C 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain D 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain E 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain F 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；290 K；SITTING DROP VAPOR DIFFUSION AT 17 DEGREE C. PROTEIN SOLUTION: 10 MG/ML IN 20 MM TRIS (PH 8.5), 50 MM NACL. CRYSTALLIZATION BUFFER: 0.1 M TRIS (PH 8.5), 0.9 M AMMONIUM PHOSPHATE.
Resolution 2.00 Å R-free 0.248
2WQJ Crystal structure of a truncated variant of the human p73 tetramerization domain Deposited 2009-08-21 Assembly 3 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain S 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain T 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain U 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain V 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain W 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain X 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；290 K；SITTING DROP VAPOR DIFFUSION AT 17 DEGREE C. PROTEIN SOLUTION: 10 MG/ML IN 20 MM TRIS (PH 8.5), 50 MM NACL. CRYSTALLIZATION BUFFER: 0.1 M TRIS (PH 8.5), 0.9 M AMMONIUM PHOSPHATE.
Resolution 2.00 Å R-free 0.248
2WQJ Crystal structure of a truncated variant of the human p73 tetramerization domain Deposited 2009-08-21 Assembly 4 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain M 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain N 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain O 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain P 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain Q 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain R 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；290 K；SITTING DROP VAPOR DIFFUSION AT 17 DEGREE C. PROTEIN SOLUTION: 10 MG/ML IN 20 MM TRIS (PH 8.5), 50 MM NACL. CRYSTALLIZATION BUFFER: 0.1 M TRIS (PH 8.5), 0.9 M AMMONIUM PHOSPHATE.
Resolution 2.00 Å R-free 0.248
2WQJ Crystal structure of a truncated variant of the human p73 tetramerization domain Deposited 2009-08-21 Assembly 5 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain 1 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain 2 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain Y 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Chain Z 351–383（33 aa） Fragment：TRUNCATED TETRAMERIZATION DOMAIN, RESIDUES 351-383
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；290 K；SITTING DROP VAPOR DIFFUSION AT 17 DEGREE C. PROTEIN SOLUTION: 10 MG/ML IN 20 MM TRIS (PH 8.5), 50 MM NACL. CRYSTALLIZATION BUFFER: 0.1 M TRIS (PH 8.5), 0.9 M AMMONIUM PHOSPHATE.
Resolution 2.00 Å R-free 0.248
2WTT Structure of the human p73 tetramerization domain (crystal form II) Deposited 2009-09-21 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain I 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Chain J 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Chain K 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Chain L 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.2；290 K；SITTING DROP VAPOR DIFFUSION AT 17 DEGREE C. PROTEIN SOLUTION: 15 MG/ML IN 20 MM TRIS (PH 8.5), 50 MM NACL. CRYSTALLIZATION BUFFER: 0.1 M SODIUM CITRATE (PH 6.2), 40% PEG 600.
Resolution 2.30 Å R-free 0.287
2WTT Structure of the human p73 tetramerization domain (crystal form II) Deposited 2009-09-21 Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Chain B 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Chain C 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Chain D 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.2；290 K；SITTING DROP VAPOR DIFFUSION AT 17 DEGREE C. PROTEIN SOLUTION: 15 MG/ML IN 20 MM TRIS (PH 8.5), 50 MM NACL. CRYSTALLIZATION BUFFER: 0.1 M SODIUM CITRATE (PH 6.2), 40% PEG 600.
Resolution 2.30 Å R-free 0.287
2WTT Structure of the human p73 tetramerization domain (crystal form II) Deposited 2009-09-21 Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain E 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Chain F 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Chain G 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Chain H 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.2；290 K；SITTING DROP VAPOR DIFFUSION AT 17 DEGREE C. PROTEIN SOLUTION: 15 MG/ML IN 20 MM TRIS (PH 8.5), 50 MM NACL. CRYSTALLIZATION BUFFER: 0.1 M SODIUM CITRATE (PH 6.2), 40% PEG 600.
Resolution 2.30 Å R-free 0.287
2WTT Structure of the human p73 tetramerization domain (crystal form II) Deposited 2009-09-21 Assembly 4 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain M 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Chain N 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Chain O 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Chain P 351–399（49 aa） Fragment：TETRAMERIZATION DOMAIN, RESIDUES 351-399
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.2；290 K；SITTING DROP VAPOR DIFFUSION AT 17 DEGREE C. PROTEIN SOLUTION: 15 MG/ML IN 20 MM TRIS (PH 8.5), 50 MM NACL. CRYSTALLIZATION BUFFER: 0.1 M SODIUM CITRATE (PH 6.2), 40% PEG 600.
Resolution 2.30 Å R-free 0.287
2XWC Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution Deposited 2010-11-03 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 112–311（200 aa） Fragment：DNA-BINDING DOMAIN, RESIDUES 112-311
Not recorded ZN ZINC ION × 4 TAM TRIS(HYDROXYETHYL)AMINOMETHANE × 2 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions 1.2M SODIUM POTASSIUM TARTRATE, 0.25% PEG MME 5000, 0.1M TRIS PH 9
Resolution 1.82 Å R-free 0.228
3VD0 structure of p73 DNA binding domain tetramer modulates p73 transactivation Deposited 2012-01-04 Assembly 1 Protein–DNA Homooligomer；Protein × 4 PDB declaration: octameric（8） Consistent with all polymers
Chain A 115–312（198 aa） Fragment：unp residue 115-312
Chain B 115–312（198 aa） Fragment：unp residue 115-312
Chain C 115–312（198 aa） Fragment：unp residue 115-312
Chain D 115–312（198 aa） Fragment：unp residue 115-312
Not recorded ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.1；298 K；0.1M MES, 0.1M Na acetate, pH 6.1, temperature 298.0K
Resolution 2.95 Å R-free 0.254
3VD0 structure of p73 DNA binding domain tetramer modulates p73 transactivation Deposited 2012-01-04 Assembly 2 Protein–DNA Homooligomer；Protein × 4 PDB declaration: octameric（8） Consistent with all polymers
Chain I 115–312（198 aa） Fragment：unp residue 115-312
Chain J 115–312（198 aa） Fragment：unp residue 115-312
Chain K 115–312（198 aa） Fragment：unp residue 115-312
Chain L 115–312（198 aa） Fragment：unp residue 115-312
Not recorded ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.1；298 K；0.1M MES, 0.1M Na acetate, pH 6.1, temperature 298.0K
Resolution 2.95 Å R-free 0.254
3VD1 structure of p73 DNA binding domain tetramer modulates p73 transactivation Deposited 2012-01-04 Assembly 1 Protein–DNA Homooligomer；Protein × 4 PDB declaration: octameric（8） Consistent with all polymers
Chain A 115–312（198 aa） Fragment：unp residue 115-312
Chain B 115–312（198 aa） Fragment：unp residue 115-312
Chain C 115–312（198 aa） Fragment：unp residue 115-312
Chain D 115–312（198 aa） Fragment：unp residue 115-312
Not recorded ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.1；298 K；0.1M MES, 0.1M Na acetate, pH 6.1, temperature 298.0K
Resolution 2.95 Å R-free 0.285
3VD1 structure of p73 DNA binding domain tetramer modulates p73 transactivation Deposited 2012-01-04 Assembly 2 Protein–DNA Homooligomer；Protein × 4 PDB declaration: octameric（8） Consistent with all polymers
Chain I 115–312（198 aa） Fragment：unp residue 115-312
Chain J 115–312（198 aa） Fragment：unp residue 115-312
Chain K 115–312（198 aa） Fragment：unp residue 115-312
Chain L 115–312（198 aa） Fragment：unp residue 115-312
Not recorded ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.1；298 K；0.1M MES, 0.1M Na acetate, pH 6.1, temperature 298.0K
Resolution 2.95 Å R-free 0.285
3VD2 structure of p73 DNA binding domain tetramer modulates p73 transactivation Deposited 2012-01-04 Assembly 1 Protein–DNA Homooligomer；Protein × 4 PDB declaration: octameric（8） Consistent with all polymers
Chain A 115–312（198 aa） Fragment：unp residues 115-312
Chain B 115–312（198 aa） Fragment：unp residues 115-312
Chain C 115–312（198 aa） Fragment：unp residues 115-312
Chain D 115–312（198 aa） Fragment：unp residues 115-312
Not recorded ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M Bis-tris, 0.1M Ammonium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K, pH 6.5
Resolution 4.00 Å R-free 0.284
3VD2 structure of p73 DNA binding domain tetramer modulates p73 transactivation Deposited 2012-01-04 Assembly 2 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain I 115–312（198 aa） Fragment：unp residues 115-312
Chain J 115–312（198 aa） Fragment：unp residues 115-312
Not recorded ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M Bis-tris, 0.1M Ammonium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K, pH 6.5
Resolution 4.00 Å R-free 0.284
4A63 Crystal structure of the p73-ASPP2 complex at 2.6A resolution Deposited 2011-10-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 112–311（200 aa） Fragment：DNA-BINDING DOMAIN, RESIDUES 1-208
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions 1.00M NA/KPO4, 0.1M ACETATE PH 4.5
Resolution 2.27 Å R-free 0.244
4A63 Crystal structure of the p73-ASPP2 complex at 2.6A resolution Deposited 2011-10-31 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 112–311（200 aa） Fragment：DNA-BINDING DOMAIN, RESIDUES 1-208
Not recorded ZN ZINC ION × 1 ACT ACETATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions 1.00M NA/KPO4, 0.1M ACETATE PH 4.5
Resolution 2.27 Å R-free 0.244
4A63 Crystal structure of the p73-ASPP2 complex at 2.6A resolution Deposited 2011-10-31 Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 112–311（200 aa） Fragment：DNA-BINDING DOMAIN, RESIDUES 1-208
Not recorded ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions 1.00M NA/KPO4, 0.1M ACETATE PH 4.5
Resolution 2.27 Å R-free 0.244
4A63 Crystal structure of the p73-ASPP2 complex at 2.6A resolution Deposited 2011-10-31 Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain G 112–311（200 aa） Fragment：DNA-BINDING DOMAIN, RESIDUES 1-208
Not recorded ZN ZINC ION × 1 ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions 1.00M NA/KPO4, 0.1M ACETATE PH 4.5
Resolution 2.27 Å R-free 0.244
4A63 Crystal structure of the p73-ASPP2 complex at 2.6A resolution Deposited 2011-10-31 Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain I 112–311（200 aa） Fragment：DNA-BINDING DOMAIN, RESIDUES 1-208
Not recorded ZN ZINC ION × 1 ACT ACETATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions 1.00M NA/KPO4, 0.1M ACETATE PH 4.5
Resolution 2.27 Å R-free 0.244
4A63 Crystal structure of the p73-ASPP2 complex at 2.6A resolution Deposited 2011-10-31 Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain K 112–311（200 aa） Fragment：DNA-BINDING DOMAIN, RESIDUES 1-208
Not recorded ZN ZINC ION × 1 ACT ACETATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions 1.00M NA/KPO4, 0.1M ACETATE PH 4.5
Resolution 2.27 Å R-free 0.244
4G82 Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element Deposited 2012-07-20 Assembly 1 Protein–DNA Homooligomer；Protein × 4 PDB declaration: octameric（8） Consistent with all polymers
Chain A 115–312（198 aa） Fragment：unp residues 115-312
Chain B 115–312（198 aa） Fragment：unp residues 115-312
Not recorded ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；298 K；0.1M TRIS, 20% PEG3350 , pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
Resolution 3.10 Å R-free 0.268
4G83 Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element Deposited 2012-07-20 Assembly 1 Protein–DNA Homooligomer；Protein × 4 PDB declaration: octameric（8） Consistent with all polymers
Chain A 115–312（198 aa）
Chain B 115–312（198 aa）
Not recorded ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.1M BTP, 20% PEG3350 , pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
Resolution 4.00 Å R-free 0.307
4GUO structure of p73 DNA binding domain complex with 12 bp DNA Deposited 2012-08-29 Assembly 1 Protein–DNA Homooligomer；Protein × 4 PDB declaration: octameric（8） Consistent with all polymers
Chain A 115–312（198 aa） Fragment：unp residues 115-312
Chain B 115–312（198 aa） Fragment：unp residues 115-312
Chain C 115–312（198 aa） Fragment：unp residues 115-312
Chain D 115–312（198 aa） Fragment：unp residues 115-312
Not recorded ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6；298 K；0.1M MES, 0.1M NA ACETATE, 15-17% PEG 20K, pH 6.0, VAPOR DIFFUSION, temperature 298K
Resolution 3.19 Å R-free 0.270
4GUO structure of p73 DNA binding domain complex with 12 bp DNA Deposited 2012-08-29 Assembly 2 Protein–DNA Homooligomer；Protein × 4 PDB declaration: octameric（8） Consistent with all polymers
Chain I 115–312（198 aa） Fragment：unp residues 115-312
Chain J 115–312（198 aa） Fragment：unp residues 115-312
Chain K 115–312（198 aa） Fragment：unp residues 115-312
Chain L 115–312（198 aa） Fragment：unp residues 115-312
Not recorded ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6；298 K；0.1M MES, 0.1M NA ACETATE, 15-17% PEG 20K, pH 6.0, VAPOR DIFFUSION, temperature 298K
Resolution 3.19 Å R-free 0.270
4GUQ Structure of mutS139F p73 DNA binding domain complexed with 20BP DNA response element Deposited 2012-08-29 Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 115–312（198 aa） Fragment：unp residues 115-312
Chain B 115–312（198 aa） Fragment：unp residues 115-312
Mutation：S139F Mutation：S139F ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；0.1 M Tris, 50-125 mM sodium acetate and 20-24% (w/v) PEG 3350, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 3.70 Å R-free 0.316
5HOB p73 homo-tetramerization domain mutant I Deposited 2016-01-19 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 351–398（48 aa） Fragment：tetramerization domain, UNP residues 351-398
Chain B 351–398（48 aa） Fragment：tetramerization domain, UNP residues 351-398
Chain C 351–398（48 aa） Fragment：tetramerization domain, UNP residues 351-398
Chain D 351–398（48 aa） Fragment：tetramerization domain, UNP residues 351-398
Mutation：E363K, K370E, E373R, R390E Mutation：E363K, K370E, E373R, R390E Mutation：E363K, K370E, E373R, R390E Mutation：E363K, K370E, E373R, R390E No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；15% w/v PEG Smear Medium, 0.1 M HEPES pH 7.5, 0.2 M magnesium chloride, 5 % 2-propanol, 10 % ethylene glycol
Resolution 1.22 Å R-free 0.214
5HOB p73 homo-tetramerization domain mutant I Deposited 2016-01-19 Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain E 351–398（48 aa） Fragment：tetramerization domain, UNP residues 351-398
Chain F 351–398（48 aa） Fragment：tetramerization domain, UNP residues 351-398
Chain G 351–398（48 aa） Fragment：tetramerization domain, UNP residues 351-398
Chain H 351–398（48 aa） Fragment：tetramerization domain, UNP residues 351-398
Mutation：E363K, K370E, E373R, R390E Mutation：E363K, K370E, E373R, R390E Mutation：E363K, K370E, E373R, R390E Mutation：E363K, K370E, E373R, R390E MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；15% w/v PEG Smear Medium, 0.1 M HEPES pH 7.5, 0.2 M magnesium chloride, 5 % 2-propanol, 10 % ethylene glycol
Resolution 1.22 Å R-free 0.214
5HOC p73 homo-tetramerization domain mutant II Deposited 2016-01-19 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 351–398（48 aa） Fragment：UNP residues 351-398
Chain B 351–398（48 aa） Fragment：UNP residues 351-398
Mutation：E363R, K370E, E373R, R390D Mutation：E363R, K370E, E373R, R390D No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；2 M Sodium chloride, 0.1 M sodium phosphate, 0.1 M potassium phosphate , 0.1 M HEPES pH 7.5
Resolution 1.36 Å R-free 0.247
5KBD Structural Studies of Transcription Factor p73 DNA Binding Domain Bound to PA26 20-mer Response Element Deposited 2016-06-03 Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 115–312（198 aa） Fragment：UNP residues 115-312
Chain B 115–312（198 aa） Fragment：UNP residues 115-312
Not recorded ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；0.1 M Tris pH 9.0, 50 mM Sodium Acetate, 16% (w/v) PEG 3350; 2:1 or 4:1 Protein:DNA ratio, 1:1 protein/DNA solution:well solution ratio
Resolution 2.80 Å R-free 0.308
6FGS Solution structure of p300Taz2-p73TA1 Deposited 2018-01-11 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 10–31（22 aa）
Not recorded ZN ZINC ION × 3 SOLUTION NMR
NMR measurement conditions pH 6.3；303 K；Ionic strength (raw mmCIF value) 50；Pressure AMBIENT
NMR sample composition 700 uM [U-13C; U-15N] Fusion construct of p300 Taz2 and the transactivation domain 1 of p73, 25 mM MES, 50 mM NaCl, 0.5 mM TCEP, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
6IJQ Solution structure of BCL-XL bound to P73-TAD peptide Deposited 2018-10-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 10–25（16 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；298 K；Ionic strength (raw mmCIF value) 150；Pressure 1
NMR sample composition 1 mM [U-13C; U-15[U-13C; U-15N]N] Bcl-xL, 2 mM p73 peptide, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.1 mM Bcl-XL, 1 mM p73 peptide, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
7EZJ Crystal structure of p73 DNA binding domain complex bound with 1 bp and 2 bp spacer DNA response elements. Deposited 2021-06-01 Assembly 1 Protein–DNA Homooligomer；Protein × 4 PDB declaration: octameric（8） Consistent with all polymers
Chain A 115–312（198 aa）
Chain B 115–312（198 aa）
Chain C 115–312（198 aa）
Chain D 115–312（198 aa）
Not recorded ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；293.15 K；100 mM MES, pH-6.0, 0.1 M Ammonium acetate, 12% w/v PEg20K
Resolution 2.90 Å R-free 0.306
7EZJ Crystal structure of p73 DNA binding domain complex bound with 1 bp and 2 bp spacer DNA response elements. Deposited 2021-06-01 Assembly 2 Protein–DNA Homooligomer；Protein × 4 PDB declaration: octameric（8） Consistent with all polymers
Chain I 115–312（198 aa）
Chain J 115–312（198 aa）
Chain K 115–312（198 aa）
Chain L 115–312（198 aa）
Not recorded ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；293.15 K；100 mM MES, pH-6.0, 0.1 M Ammonium acetate, 12% w/v PEg20K
Resolution 2.90 Å R-free 0.306
7EZJ Crystal structure of p73 DNA binding domain complex bound with 1 bp and 2 bp spacer DNA response elements. Deposited 2021-06-01 Assembly 3 Protein–DNA Homooligomer；Protein × 4 PDB declaration: octameric（8） Consistent with all polymers
Chain a 115–312（198 aa）
Chain b 115–312（198 aa）
Chain c 115–312（198 aa）
Chain d 115–312（198 aa）
Not recorded ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；293.15 K；100 mM MES, pH-6.0, 0.1 M Ammonium acetate, 12% w/v PEg20K
Resolution 2.90 Å R-free 0.306
7EZJ Crystal structure of p73 DNA binding domain complex bound with 1 bp and 2 bp spacer DNA response elements. Deposited 2021-06-01 Assembly 4 Protein–DNA Homooligomer；Protein × 4 PDB declaration: octameric（8） Consistent with all polymers
Chain i 115–312（198 aa）
Chain j 115–312（198 aa）
Chain k 115–312（198 aa）
Chain l 115–312（198 aa）
Not recorded ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；293.15 K；100 mM MES, pH-6.0, 0.1 M Ammonium acetate, 12% w/v PEg20K
Resolution 2.90 Å R-free 0.306
8P9C Crystal structure of p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 F11 Deposited 2023-06-05 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain B 351–398（48 aa）
Not recorded EDO 1,2-ETHANEDIOL × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；0.2M ammonium acetate, 25% PEG3350, 0.1M HEPES pH 7.5
Resolution 1.76 Å R-free 0.210
8P9D Crystal structure of p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 A2 Deposited 2023-06-05 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain B 351–398（48 aa）
Chain D 351–398（48 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293.15 K；20% PEG3350, 0.1M bis-tris propane pH 7.0, 0.2M salicylic, sodium salt
Resolution 2.70 Å R-free 0.252
8P9E Crystal structure of wild type p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 F11 Deposited 2023-06-05 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: trimeric（3） Review required
Chain B 351–398（48 aa）
Not recorded GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293.15 K；0.2M sodium chloride, 25% PEG3350, 0.1M bis-tris pH 6.5
Resolution 2.25 Å R-free 0.250
9GLQ Crystal structure of p73 tetramerisation domain in complex with darpins 1800 Deposited 2024-08-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 351–398（48 aa）
Chain B 351–398（48 aa）
Not recorded CO COBALT (II) ION × 2 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；30% PEG2000MME, 0.15M potassium bromide
Resolution 2.10 Å R-free 0.248
9GNB Structure of p73 SAM domain in complex with DARPin B9 Deposited 2024-09-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 489–550（62 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 9；293 K；20% PEG6000, 0.1M bicine pH 9.0
Resolution 1.80 Å R-free 0.234

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.