Current Protein Identity：O95619
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 5R68 XChem group deposition -- Crystal Structure of human YEATS4 in complex with FM000199e Deposited 2020-02-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
18–190（173 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 RYD (1-methylbenzotriazol-5-yl)methanol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1M tris pH 7.5, 0.15M lithium sulfate, 40% PEG400
|
Resolution 1.64 Å R-free 0.251 |
| 5R68 XChem group deposition -- Crystal Structure of human YEATS4 in complex with FM000199e Deposited 2020-02-29 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
18–190（173 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 3 RYD (1-methylbenzotriazol-5-yl)methanol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1M tris pH 7.5, 0.15M lithium sulfate, 40% PEG400
|
Resolution 1.64 Å R-free 0.251 |
| 5R69 XChem group deposition -- Crystal Structure of human YEATS4 in complex with XS038644e Deposited 2020-02-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
18–190（173 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 ZHA ~{N}-(5-oxidanylidene-7,8-dihydro-6~{H}-naphthalen-2-yl)ethanamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1M tris pH 7.5, 0.15M lithium sulfate, 40% PEG400
|
Resolution 1.83 Å R-free 0.248 |
| 5R69 XChem group deposition -- Crystal Structure of human YEATS4 in complex with XS038644e Deposited 2020-02-29 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
18–190（173 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 ZHA ~{N}-(5-oxidanylidene-7,8-dihydro-6~{H}-naphthalen-2-yl)ethanamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1M tris pH 7.5, 0.15M lithium sulfate, 40% PEG400
|
Resolution 1.83 Å R-free 0.248 |
| 5VNA Crystal structure of human YEATS domain Deposited 2017-04-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–148（148 aa）
Fragment：UNP residues 1-148
|
Not recorded | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9.4；290 K；1.24 M ammonium sulfate, 100 mM CHES pH 9.4
|
Resolution 2.10 Å R-free 0.222 |
| 5VNA Crystal structure of human YEATS domain Deposited 2017-04-29 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–148（148 aa）
Fragment：UNP residues 1-148
|
Not recorded | SO4 SULFATE ION × 2 EDO 1,2-ETHANEDIOL × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9.4；290 K；1.24 M ammonium sulfate, 100 mM CHES pH 9.4
|
Resolution 2.10 Å R-free 0.222 |
| 5VNA Crystal structure of human YEATS domain Deposited 2017-04-29 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
1–148（148 aa）
Fragment：UNP residues 1-148
|
Not recorded | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9.4；290 K；1.24 M ammonium sulfate, 100 mM CHES pH 9.4
|
Resolution 2.10 Å R-free 0.222 |
| 5VNA Crystal structure of human YEATS domain Deposited 2017-04-29 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
1–148（148 aa）
Fragment：UNP residues 1-148
|
Not recorded | SO4 SULFATE ION × 1 NHE 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9.4；290 K；1.24 M ammonium sulfate, 100 mM CHES pH 9.4
|
Resolution 2.10 Å R-free 0.222 |
| 5VNB YEATS in complex with histone H3 Deposited 2017-04-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–148（148 aa）
Fragment：UNP residues 1-148
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9.4；290 K；1.36 M ammonium sulfate, 100 mM CHES pH 9.4
|
Resolution 2.40 Å R-free 0.248 |
| 5VNB YEATS in complex with histone H3 Deposited 2017-04-29 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–148（148 aa）
Fragment：UNP residues 1-148
|
Not recorded | EDO 1,2-ETHANEDIOL × 6 SO4 SULFATE ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9.4；290 K；1.36 M ammonium sulfate, 100 mM CHES pH 9.4
|
Resolution 2.40 Å R-free 0.248 |
| 5VNB YEATS in complex with histone H3 Deposited 2017-04-29 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
1–148（148 aa）
Fragment：UNP residues 1-148
|
Not recorded | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9.4；290 K；1.36 M ammonium sulfate, 100 mM CHES pH 9.4
|
Resolution 2.40 Å R-free 0.248 |
| 5VNB YEATS in complex with histone H3 Deposited 2017-04-29 | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
1–148（148 aa）
Fragment：UNP residues 1-148
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9.4；290 K；1.36 M ammonium sulfate, 100 mM CHES pH 9.4
|
Resolution 2.40 Å R-free 0.248 |
| 5XTZ Crystal structure of GAS41 YEATS bound to H3K27ac peptide Deposited 2017-06-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
15–159（145 aa）
Fragment：UNP RESIDUES 15-159
Chain B
15–159（145 aa）
Fragment：UNP RESIDUES 15-159
Chain C
15–159（145 aa）
Fragment：UNP RESIDUES 15-159
Chain D
15–159（145 aa）
Fragment：UNP RESIDUES 15-159
|
Not recorded | ACT ACETATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；291 K；0.1 M sodium acetate trihydrate, pH 4.6, 4.0 M ammonium acetate
|
Resolution 2.10 Å R-free 0.233 |
| 5XTZ Crystal structure of GAS41 YEATS bound to H3K27ac peptide Deposited 2017-06-21 | Assembly 2 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
15–159（145 aa）
Fragment：UNP RESIDUES 15-159
Chain B
15–159（145 aa）
Fragment：UNP RESIDUES 15-159
Chain C
15–159（145 aa）
Fragment：UNP RESIDUES 15-159
Chain D
15–159（145 aa）
Fragment：UNP RESIDUES 15-159
|
Not recorded | ACT ACETATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；291 K；0.1 M sodium acetate trihydrate, pH 4.6, 4.0 M ammonium acetate
|
Resolution 2.10 Å R-free 0.233 |
| 5Y8V Crystal structure of GAS41 Deposited 2017-08-21 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
21–160（140 aa）
Fragment：UNP residues 21-160
|
Not recorded | MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 6；291 K；0.1M MES pH 6.5, 1.6M MgSO4
|
Resolution 2.61 Å R-free 0.280 |
| 5Y8V Crystal structure of GAS41 Deposited 2017-08-21 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
21–160（140 aa）
Fragment：UNP residues 21-160
|
Not recorded | MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 6；291 K；0.1M MES pH 6.5, 1.6M MgSO4
|
Resolution 2.61 Å R-free 0.280 |
| 5Y8V Crystal structure of GAS41 Deposited 2017-08-21 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
21–160（140 aa）
Fragment：UNP residues 21-160
|
Not recorded | MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 6；291 K；0.1M MES pH 6.5, 1.6M MgSO4
|
Resolution 2.61 Å R-free 0.280 |
| 5Y8V Crystal structure of GAS41 Deposited 2017-08-21 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
21–160（140 aa）
Fragment：UNP residues 21-160
|
Not recorded | MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 6；291 K；0.1M MES pH 6.5, 1.6M MgSO4
|
Resolution 2.61 Å R-free 0.280 |
| 7EIF Crystal structure of GAS41 YEATS domain Deposited 2021-03-30 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
19–159（141 aa）
|
Not recorded | GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100 mM Bis-Tris buffer (pH 5.9) containing 3.3 M NaCl
|
Resolution 1.58 Å R-free 0.158 |
| 7JFY GAS41 YEATS domain in complex with 5 Deposited 2020-07-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
1–148（148 aa）
Chain B
1–148（148 aa）
Chain C
1–148（148 aa）
Chain D
1–148（148 aa）
|
Not recorded | V91 N-(5-{3-[(2S)-1,3-thiazolidin-2-yl]azetidine-1-carbonyl}thiophen-2-yl)-L-prolinamide × 4 EDO 1,2-ETHANEDIOL × 6 DMS DIMETHYL SULFOXIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.3；277 K；0.1 M Tris, pH 7.3, 0.2 M magnesium chloride, 2.2 M sodium chloride
|
Resolution 2.10 Å R-free 0.264 |
| 8DKB Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b Deposited 2022-07-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–149（149 aa）
|
Not recorded | SJI N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M sodium citrate tribasic dihydrate (pH 5.6), 2% (v/v) tacsimate (pH 5.0), and 16% PEG 3350, 0.1M Ammonium sulfate
|
Resolution 2.58 Å R-free 0.226 |
| 8DKB Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b Deposited 2022-07-05 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–149（149 aa）
|
Not recorded | SJI N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M sodium citrate tribasic dihydrate (pH 5.6), 2% (v/v) tacsimate (pH 5.0), and 16% PEG 3350, 0.1M Ammonium sulfate
|
Resolution 2.58 Å R-free 0.226 |
| 8DKB Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b Deposited 2022-07-05 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
1–149（149 aa）
|
Not recorded | SJI N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M sodium citrate tribasic dihydrate (pH 5.6), 2% (v/v) tacsimate (pH 5.0), and 16% PEG 3350, 0.1M Ammonium sulfate
|
Resolution 2.58 Å R-free 0.226 |
| 8DKB Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b Deposited 2022-07-05 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
1–149（149 aa）
|
Not recorded | SJI N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M sodium citrate tribasic dihydrate (pH 5.6), 2% (v/v) tacsimate (pH 5.0), and 16% PEG 3350, 0.1M Ammonium sulfate
|
Resolution 2.58 Å R-free 0.226 |
| 8DKB Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b Deposited 2022-07-05 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
1–149（149 aa）
|
Not recorded | SJI N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M sodium citrate tribasic dihydrate (pH 5.6), 2% (v/v) tacsimate (pH 5.0), and 16% PEG 3350, 0.1M Ammonium sulfate
|
Resolution 2.58 Å R-free 0.226 |
| 8DKB Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b Deposited 2022-07-05 | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain F
1–149（149 aa）
|
Not recorded | SJI N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M sodium citrate tribasic dihydrate (pH 5.6), 2% (v/v) tacsimate (pH 5.0), and 16% PEG 3350, 0.1M Ammonium sulfate
|
Resolution 2.58 Å R-free 0.226 |
| 8DKB Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b Deposited 2022-07-05 | Assembly 7 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain G
1–149（149 aa）
|
Not recorded | SJI N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M sodium citrate tribasic dihydrate (pH 5.6), 2% (v/v) tacsimate (pH 5.0), and 16% PEG 3350, 0.1M Ammonium sulfate
|
Resolution 2.58 Å R-free 0.226 |
| 8DKB Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b Deposited 2022-07-05 | Assembly 8 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain H
1–149（149 aa）
|
Not recorded | SJI N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M sodium citrate tribasic dihydrate (pH 5.6), 2% (v/v) tacsimate (pH 5.0), and 16% PEG 3350, 0.1M Ammonium sulfate
|
Resolution 2.58 Å R-free 0.226 |
| 8I60 Crystal structure of GAS41 YEATS domain in complex with histone H3K27cr Deposited 2023-01-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
11–150（140 aa）
|
Not recorded | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；288 K；Ammonium sulfate
|
Resolution 2.30 Å R-free 0.291 |
| 8I60 Crystal structure of GAS41 YEATS domain in complex with histone H3K27cr Deposited 2023-01-26 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
11–150（140 aa）
|
Not recorded | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；288 K；Ammonium sulfate
|
Resolution 2.30 Å R-free 0.291 |
| 8IIY Crystal structure of MBP fused GAS41 YEATS domain in complex with H3K14ac peptide Deposited 2023-02-24 | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
19–159（141 aa）
|
Mutation：D108A, K109A, E198A, N199A, K265A | GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100 mM Tris buffer (pH 8.5) containing 20% (w/v) PEG monomethyl ether 2000, 200 mM trimethylamine N-oxide
|
Resolution 2.15 Å R-free 0.247 |
| 8IIZ Crystal structure of MBP fused GAS41 YEATS domain in complex with H3K27ac peptide Deposited 2023-02-24 | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
19–159（141 aa）
|
Mutation：D108A, K109A, E198A, N199A, K265A | GOL GLYCEROL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100 mM Tris buffer (pH 8.5) containing 20% (w/v) PEG monomethyl ether 2000, 200 mM trimethylamine N-oxide
|
Resolution 2.10 Å R-free 0.301 |
| 8IJ0 Crystal structure of GAS41 YEATS domain in complex with H3K9ac peptide Deposited 2023-02-24 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
19–159（141 aa）
|
Not recorded | GOL GLYCEROL × 3 SO4 SULFATE ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100 mM Na-HEPES buffer (pH 7.5) containing 5% (w/v) PEG 400 and 2 M ammonium sulfate
|
Resolution 1.52 Å R-free 0.189 |
| 8IJ0 Crystal structure of GAS41 YEATS domain in complex with H3K9ac peptide Deposited 2023-02-24 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
19–159（141 aa）
|
Not recorded | GOL GLYCEROL × 3 SO4 SULFATE ION × 4 1PE PENTAETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100 mM Na-HEPES buffer (pH 7.5) containing 5% (w/v) PEG 400 and 2 M ammonium sulfate
|
Resolution 1.52 Å R-free 0.189 |
| 8X15 Structure of nucleosome-bound SRCAP-C in the apo state Deposited 2023-11-06 | Assembly 1 Protein–DNA Heteromer；Protein × 23 PDB declaration: 25-meric（25） Consistent with all polymers |
Chain W
1–227（227 aa）
|
Not recorded | ADP ADENOSINE-5'-DIPHOSPHATE × 6 ATP ADENOSINE-5'-TRIPHOSPHATE × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 8X19 Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state Deposited 2023-11-06 | Assembly 1 Protein–DNA Heteromer；Protein × 23 PDB declaration: 25-meric（25） Consistent with all polymers |
Chain W
1–227（227 aa）
|
Not recorded | ADP ADENOSINE-5'-DIPHOSPHATE × 7 MG MAGNESIUM ION × 1 BEF BERYLLIUM TRIFLUORIDE ION × 1 ATP ADENOSINE-5'-TRIPHOSPHATE × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 8X1C Structure of nucleosome-bound SRCAP-C in the ADP-bound state Deposited 2023-11-06 | Assembly 1 Protein–DNA Heteromer；Protein × 23 PDB declaration: 25-meric（25） Consistent with all polymers |
Chain W
1–227（227 aa）
|
Not recorded | ADP ADENOSINE-5'-DIPHOSPHATE × 7 ATP ADENOSINE-5'-TRIPHOSPHATE × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9O4Y GAS41 YEATS domain in complex with DLG-1 Deposited 2025-04-09 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–148（148 aa）
|
Not recorded | PEG DI(HYDROXYETHYL)ETHER × 1 SO4 SULFATE ION × 1 A1B9P N-[5-(3-{(5M)-5-[3-(aminomethyl)phenyl]-1,3-thiazol-2-yl}azetidine-1-carbonyl)thiophen-2-yl]-L-prolinamide × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1260 mM Ammonium sulfate, 100 mM HEPES, pH 7.5, 25% Glycerol
|
Resolution 2.30 Å R-free 0.258 |
| 9O4Y GAS41 YEATS domain in complex with DLG-1 Deposited 2025-04-09 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–148（148 aa）
|
Not recorded | A1B9P N-[5-(3-{(5M)-5-[3-(aminomethyl)phenyl]-1,3-thiazol-2-yl}azetidine-1-carbonyl)thiophen-2-yl]-L-prolinamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1260 mM Ammonium sulfate, 100 mM HEPES, pH 7.5, 25% Glycerol
|
Resolution 2.30 Å R-free 0.258 |
| 9O4Y GAS41 YEATS domain in complex with DLG-1 Deposited 2025-04-09 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
1–148（148 aa）
|
Not recorded | A1B9P N-[5-(3-{(5M)-5-[3-(aminomethyl)phenyl]-1,3-thiazol-2-yl}azetidine-1-carbonyl)thiophen-2-yl]-L-prolinamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1260 mM Ammonium sulfate, 100 mM HEPES, pH 7.5, 25% Glycerol
|
Resolution 2.30 Å R-free 0.258 |
| 9O4Y GAS41 YEATS domain in complex with DLG-1 Deposited 2025-04-09 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
1–148（148 aa）
|
Not recorded | A1B9P N-[5-(3-{(5M)-5-[3-(aminomethyl)phenyl]-1,3-thiazol-2-yl}azetidine-1-carbonyl)thiophen-2-yl]-L-prolinamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1260 mM Ammonium sulfate, 100 mM HEPES, pH 7.5, 25% Glycerol
|
Resolution 2.30 Å R-free 0.258 |
| 9X8S Crystal structure of the human GAS41 YEATS domain in complex with an acetylated YFV capsid peptide (K4ac) Deposited 2025-10-20 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
15–146（132 aa）
Chain B
15–146（132 aa）
Chain C
15–146（132 aa）
Chain D
15–146（132 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；289.15 K；Sodium sulfate , Bis-Tris propane (pH= 6.5), PEG 3350
|
Resolution 1.70 Å R-free 0.206 |
| 9X8U Crystal structure of the human GAS41 YEATS domain in complex with an acetylated YFV capsid peptide (K8ac) Deposited 2025-10-20 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
15–145（131 aa）
Chain B
15–145（131 aa）
Chain C
15–145（131 aa）
Chain D
15–145（131 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；289.15 K；Sodium sulfate , Bis-Tris propane (pH= 6.5), PEG 3350
|
Resolution 3.00 Å R-free 0.266 |