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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P04233 New Search
18PDB entries
25Biological assembly
32chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1A6A THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3 Deposited 1998-02-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 103–117（15 aa） Fragment：CLIP FRAGMENT 87 - 101 OF INVARIANT CHAIN
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 4.5；12% PEG 4K, 100 MM MGCL2, 100 MM ACETATE BUFFER, PH 4.5
Resolution 2.75 Å R-free 0.325
1A6A THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3 Deposited 1998-02-22 Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain C 103–117（15 aa） Fragment：CLIP FRAGMENT 87 - 101 OF INVARIANT CHAIN
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 4.5；12% PEG 4K, 100 MM MGCL2, 100 MM ACETATE BUFFER, PH 4.5
Resolution 2.75 Å R-free 0.325
1ICF CRYSTAL STRUCTURE OF MHC CLASS II ASSOCIATED P41 II FRAGMENT IN COMPLEX WITH CATHEPSIN L Deposited 1999-01-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain I 210–274（65 aa） Fragment：THYROGLOBULIN TYPE-1 DOMAIN
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.1；SITTING DROP VAPOR DIFFUSION METHOD RESERVOIR CONTAINED 1ML OF 0.2 M NA- ACETATE TRIHYDRATE, 30% W/V PEG 8K AND 0.1M MES, PH 6.1. DROP WAS COMPOSED OF 2 MICRO L OF RESERVOIR SOLUTION AND 2 MICRO L OF THE COMPLEX (10 MG/ML) IN 20MM NA-ACETATE AND 1MM EDTA, PH 5.0.
Resolution 2.00 Å R-free 0.213
1ICF CRYSTAL STRUCTURE OF MHC CLASS II ASSOCIATED P41 II FRAGMENT IN COMPLEX WITH CATHEPSIN L Deposited 1999-01-07 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain J 210–274（65 aa） Fragment：THYROGLOBULIN TYPE-1 DOMAIN
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.1；SITTING DROP VAPOR DIFFUSION METHOD RESERVOIR CONTAINED 1ML OF 0.2 M NA- ACETATE TRIHYDRATE, 30% W/V PEG 8K AND 0.1M MES, PH 6.1. DROP WAS COMPOSED OF 2 MICRO L OF RESERVOIR SOLUTION AND 2 MICRO L OF THE COMPLEX (10 MG/ML) IN 20MM NA-ACETATE AND 1MM EDTA, PH 5.0.
Resolution 2.00 Å R-free 0.213
1ICF CRYSTAL STRUCTURE OF MHC CLASS II ASSOCIATED P41 II FRAGMENT IN COMPLEX WITH CATHEPSIN L Deposited 1999-01-07 Assembly 3 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain I 210–274（65 aa） Fragment：THYROGLOBULIN TYPE-1 DOMAIN
Chain J 210–274（65 aa） Fragment：THYROGLOBULIN TYPE-1 DOMAIN
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.1；SITTING DROP VAPOR DIFFUSION METHOD RESERVOIR CONTAINED 1ML OF 0.2 M NA- ACETATE TRIHYDRATE, 30% W/V PEG 8K AND 0.1M MES, PH 6.1. DROP WAS COMPOSED OF 2 MICRO L OF RESERVOIR SOLUTION AND 2 MICRO L OF THE COMPLEX (10 MG/ML) IN 20MM NA-ACETATE AND 1MM EDTA, PH 5.0.
Resolution 2.00 Å R-free 0.213
1IIE HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN Deposited 1999-02-02 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 118–192（75 aa） Fragment：ECTOPLASMIC TRIMERIZATION DOMAIN (RESIDUES 118-192)
Chain B 118–192（75 aa） Fragment：ECTOPLASMIC TRIMERIZATION DOMAIN (RESIDUES 118-192)
Chain C 118–192（75 aa） Fragment：ECTOPLASMIC TRIMERIZATION DOMAIN (RESIDUES 118-192)
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.7；298 K；Pressure 1
Resolution not provided
1L3H NMR structure of P41icf, a potent inhibitor of human cathepsin L Deposited 2002-02-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 210–274（65 aa） Fragment：THYROGLOBULIN-LIKE DOMAIN
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5.7；288 K；Pressure ambient
NMR sample composition 1mM P41icf; 20mM phosphate buffer, 0.01mM NaN3 | 85% H20, 15% D2O
Resolution not provided
3PDO Crystal Structure of HLA-DR1 with CLIP102-120 Deposited 2010-10-23 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 102–120（19 aa）
Not recorded GOL GLYCEROL × 2 FMT FORMIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；PEG 3350, NaCitrate, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 1.95 Å R-free 0.240
3PGC Crystal Structure of HLA-DR1 with CLIP106-120, flipped peptide orientation Deposited 2010-11-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 106–120（15 aa） Fragment：UNP residues 106-120
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；PEG 1500, MIB buffer, pH 6.0, vapor diffusion, sitting drop, temperature 298K
Resolution 2.66 Å R-free 0.250
3PGC Crystal Structure of HLA-DR1 with CLIP106-120, flipped peptide orientation Deposited 2010-11-01 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain F 106–120（15 aa） Fragment：UNP residues 106-120
Not recorded PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；PEG 1500, MIB buffer, pH 6.0, vapor diffusion, sitting drop, temperature 298K
Resolution 2.66 Å R-free 0.250
3PGD Crystal Structure of HLA-DR1 with CLIP106-120, canonical peptide orientation Deposited 2010-11-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 106–120（15 aa） Fragment：UNP residues 106-120
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；PEG 3350, NaCitrate, BisTris propane, pH 6.5, vapor diffusion, sitting drop, temperature 277K
Resolution 2.72 Å R-free 0.242
3PGD Crystal Structure of HLA-DR1 with CLIP106-120, canonical peptide orientation Deposited 2010-11-01 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain F 106–120（15 aa） Fragment：UNP residues 106-120
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；PEG 3350, NaCitrate, BisTris propane, pH 6.5, vapor diffusion, sitting drop, temperature 277K
Resolution 2.72 Å R-free 0.242
3QXA HLA-DR1 bound with CLIP peptide Deposited 2011-03-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 103–117（15 aa） Fragment：CLIP region
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；277 K；PEG 4000, 10% Glycerol, 100mM Sodium Acetate pH 5.6, 5mM DTT, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.71 Å R-free 0.235
3QXA HLA-DR1 bound with CLIP peptide Deposited 2011-03-01 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain F 103–117（15 aa） Fragment：CLIP region
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；277 K；PEG 4000, 10% Glycerol, 100mM Sodium Acetate pH 5.6, 5mM DTT, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.71 Å R-free 0.235
3QXD F54C HLA-DR1 bound with CLIP peptide Deposited 2011-03-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 103–117（15 aa） Fragment：CLIP region
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；277 K；PEG 4000, 10% Glycerol, 100mM Sodium Acetate pH 5.6, 5mM DTT, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.30 Å R-free 0.221
3QXD F54C HLA-DR1 bound with CLIP peptide Deposited 2011-03-01 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain F 103–117（15 aa） Fragment：CLIP region
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；277 K；PEG 4000, 10% Glycerol, 100mM Sodium Acetate pH 5.6, 5mM DTT, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.30 Å R-free 0.221
4AEN HLA-DR1 with covalently linked CLIP106-120 in reversed orientation Deposited 2012-01-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 106–120（15 aa） Fragment：RESIDUES 106-120
Not recorded GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions 2 M (NH4)2SO4, 0.1 M TRIS, PH 8.0
Resolution 2.20 Å R-free 0.221
4AH2 HLA-DR1 with covalently linked CLIP106-120 in canonical orientation Deposited 2012-02-03 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 106–120（15 aa） Fragment：EXTRACELLULAR DOMAIN, RESIDUES 106-120,30-227
Not recorded GOL GLYCEROL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；0.2 M LICL, 20% (W/V) PEG6000, 0.1 M HEPES, PH 7.0
Resolution 2.36 Å R-free 0.240
4X5W HLA-DR1 with CLIP102-120(M107W) Deposited 2014-12-06 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 102–120（19 aa） Fragment：extracellular, UNP residues 102-120
Mutation：M107W No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；298 K；0.2 M K/Na-tartrate, 20% (w/v) PEG3350, 0.1M BisTrisPropane, pH 8.5
Resolution 1.34 Å R-free 0.170
8VRW Cryo-EM structure of human invariant chain in complex with HLA-DR15 Deposited 2024-01-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count
Chain C 2–296（295 aa）
Chain F 2–296（295 aa）
Chain I 2–296（295 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.03 Å
8VSJ Engineered peptide-specific binder in complex with HLA-DR1/CLIP Deposited 2024-01-24 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain P 103–117（15 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.3
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
8VSP Cryo-EM structure of human invariant chain in complex with HLA-DQ Deposited 2024-01-24 Assembly 1 Protein heterocomplex Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count
Chain C 2–296（295 aa）
Chain F 2–296（295 aa）
Chain I 2–296（295 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.12 Å
9CYL Structure of LAG3 loop1 deletion bound to the MHC class II molecule I-A(b) Deposited 2024-08-02 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain P 103–117（15 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；293.15 K；1% w/v Tryptone, 0.001 M Sodium azide, 0.05 M HEPES sodium pH 7.0, 12% w/v Polyethylene glycol 3,350
Resolution 4.66 Å R-free 0.326
9CYM Structure of LAG3 bound to the MHC class II molecule I-A(b) Deposited 2024-08-02 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain P 103–117（15 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293.15 K；0.15 M Ammonium sulfate, 0.1 M Tris 8.0 and 15 % w/v PEG 4000
Resolution 3.84 Å R-free 0.307
9EJH Peptide-independent T cell receptor recognition of HLA-DQ2 Deposited 2024-11-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain C 110–122（13 aa） Fragment：UNP residues 110-122
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ACT ACETATE ION × 4 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；8% Tacsimate, pH 8.0, 20-24% w/v PEG3350
Resolution 2.45 Å R-free 0.232

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.