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8vrw

Cryo-EM structure of human invariant chain in complex with HLA-DR15

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

HLA class II histocompatibility antigen, DR alpha chain

Homo sapiens

UniProt P01903

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 HLA class II histocompatibility antigen, DRB1 beta chain × 3 （P01911） HLA class II histocompatibility antigen gamma chain × 3 （P04233） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1a6a 1a6a 1aqd 1aqd 1aqd 1aqd 1bx2 1bx2 1bx2 1d5m 1d5x 1d5z

220 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name DRA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–254； UniProt 1–254 Author chain D； PDBConstruct 1–254； UniProt 1–254 Author chain G； PDBConstruct 1–254； UniProt 1–254

HLA class II histocompatibility antigen, DRB1 beta chain

Homo sapiens

UniProt P01911

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 HLA class II histocompatibility antigen, DR alpha chain × 3 （P01903） HLA class II histocompatibility antigen gamma chain × 3 （P04233） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2wbj 2wbj 5v4m 5v4m 5v4m 5v4m 8pje 8pje 8pjf 8pjg 8tbp 8tbp

18 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name DRB1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–266； UniProt 1–266 Author chain E； PDBConstruct 1–266； UniProt 1–266 Author chain H； PDBConstruct 1–266； UniProt 1–266

HLA class II histocompatibility antigen gamma chain

Homo sapiens

UniProt P04233

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 HLA class II histocompatibility antigen, DR alpha chain × 3 （P01903） HLA class II histocompatibility antigen, DRB1 beta chain × 3 （P01911） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1l3h

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
1iie

1 assemblies

Heteromeric or nucleic-acid complex
1a6a 1a6a 1icf 1icf 1icf 3pdo 3pgc 3pgc 3pgd 3pgd 3qxa 3qxa

23 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name HG2A_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 14–308； UniProt 2–296 Author chain F； PDBConstruct 14–308； UniProt 2–296 Author chain I； PDBConstruct 14–308； UniProt 2–296

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8vrw
Deposition date deposition_date2024-01-22
Structure title titleCryo-EM structure of human invariant chain in complex with HLA-DR15
Keywords keywordsAntigen presentation, membrane protein, trimeric complex, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8vrw__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8vrw__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8vrw__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）35.91 Å
Rg (electron density)34.84 Å
Total Rg35.44 Å
Atom count10413
Residues1272
Excluded volume184740 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8vrw__assembly_1__model_1 nonameric （9） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)