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9b7b

Crystal structure of humanized 44H10 Fab Version 22 in complex with HLA-DR (HLA-DRA*01:01/HLA-DRB1*04:01)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

HLA class II histocompatibility antigen, DR alpha chain

Homo sapiens

UniProt P01903

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Hemagglutinin HA1 chain, HLA class II histocompatibility antigen DR beta chain × 1 h44H10-V22 Antibody, heavy chain × 1 h44H10-V22 Antibody, light chain × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 SULFATE ION × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 Hemagglutinin HA1 chain, HLA class II histocompatibility antigen DR beta chain × 1 h44H10-V22 Antibody, heavy chain × 1 h44H10-V22 Antibody, light chain × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 SULFATE ION × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1a6a 1a6a 1aqd 1aqd 1aqd 1aqd 1bx2 1bx2 1bx2 1d5m 1d5x 1d5z

220 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name DRA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–181； UniProt 26–206 Author chain E； PDBConstruct 1–181； UniProt 26–206

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9b7b
Deposition date deposition_date2024-03-27
Structure title titleCrystal structure of humanized 44H10 Fab Version 22 in complex with HLA-DR (HLA-DRA*01:01/HLA-DRB1*04:01)
Keywords keywordsAntibody, Humanized, MHC class II, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9b7b__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9b7b__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9b7b__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）32.24 Å
Rg (electron density)31.54 Å
Total Rg32.25 Å
Atom count6454
Residues816
Excluded volume114390 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9b7b__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 9b7b__assembly_2__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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7. Citations (1)