当前蛋白身份:Q03347 重新检索
本组结构的主要差异维度
构建体不同 突变/修饰不同 组装状态不同 配体/离子不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
1EAN THE RUNX1 Runt domain at 1.70A resolution: A structural switch and specifically bound chloride ions modulate DNA binding 提交 2001-07-13 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 46–185(140 aa) 片段:RUNT DOMAIN RESIDUES 46-185
突变:YES CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.5;30% MPEG 350, 5-10% PEG 3350, 70 MM NA CACODYLATE, PH 6.5
分辨率 1.70 Å R-free 0.222
1EAO THE RUNX1 Runt domain at 1.4A resolution: a structural switch and specifically bound chloride ions modulate DNA binding 提交 2001-07-14 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 46–185(140 aa) 片段:RUNT DOMAIN RESIDUES 46-185
突变:YES BR BROMIDE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.4;25 % PEG 3350, 16% GLYCEROL, 130 MM NA CACODYLATE, PH 6.4
分辨率 1.40 Å R-free 0.173
1EAO THE RUNX1 Runt domain at 1.4A resolution: a structural switch and specifically bound chloride ions modulate DNA binding 提交 2001-07-14 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 46–185(140 aa) 片段:RUNT DOMAIN RESIDUES 46-185
突变:YES BR BROMIDE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.4;25 % PEG 3350, 16% GLYCEROL, 130 MM NA CACODYLATE, PH 6.4
分辨率 1.40 Å R-free 0.173
1EAQ The RUNX1 Runt domain at 1.25A resolution: A structural switch and specifically bound chloride ions modulate DNA binding 提交 2001-07-14 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 46–185(140 aa) 片段:RUNT DOMAIN RESIDUES 36-185
突变:YES 非标准单体:是(mmCIF未提供具体位点) CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.4;25 % PEG 3350, 16% GLYCEROL, 130 MM NA CACODYLATE, PH 6.4
分辨率 1.25 Å R-free 0.167
1EAQ The RUNX1 Runt domain at 1.25A resolution: A structural switch and specifically bound chloride ions modulate DNA binding 提交 2001-07-14 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 46–185(140 aa) 片段:RUNT DOMAIN RESIDUES 36-185
突变:YES 非标准单体:是(mmCIF未提供具体位点) CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.4;25 % PEG 3350, 16% GLYCEROL, 130 MM NA CACODYLATE, PH 6.4
分辨率 1.25 Å R-free 0.167
1HJB CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN AND C/EBPBETA BZIP HOMODIMER BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER 提交 2001-01-11 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 C 60–182(123 aa) 片段:RESIDUES 60-182
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.6;297 K;5 MM MGSO4, 3% W/V PEG 4000, 1% V/V DIOXANE, 50 MM MES BUFFER, PH 5.6 AT 24 DEGREES C
分辨率 3.00 Å R-free 0.313
1HJB CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN AND C/EBPBETA BZIP HOMODIMER BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER 提交 2001-01-11 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 F 60–182(123 aa) 片段:RESIDUES 60-182
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.6;297 K;5 MM MGSO4, 3% W/V PEG 4000, 1% V/V DIOXANE, 50 MM MES BUFFER, PH 5.6 AT 24 DEGREES C
分辨率 3.00 Å R-free 0.313
1HJC CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER 提交 2001-01-11 Assembly 1 蛋白–DNA 单体;蛋白 × 1 PDB 声明:trimeric(3) 与全部聚合物一致
链 A 60–182(123 aa) 片段:RESIDUES 60-182
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;297 K;0.2 M AMMONIUM ACETATE, 0.15 M MAGNESIUM ACETATE, 5% W/V PEG 4000, 50 MM HEPES BUFFER, PH 7.0 AT 24 DEGREES C
分辨率 2.65 Å R-free 0.263
1HJC CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER 提交 2001-01-11 Assembly 2 蛋白–DNA 单体;蛋白 × 1 PDB 声明:trimeric(3) 与全部聚合物一致
链 D 60–182(123 aa) 片段:RESIDUES 60-182
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;297 K;0.2 M AMMONIUM ACETATE, 0.15 M MAGNESIUM ACETATE, 5% W/V PEG 4000, 50 MM HEPES BUFFER, PH 7.0 AT 24 DEGREES C
分辨率 2.65 Å R-free 0.263
1IO4 CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN-CBFBETA CORE DOMAIN HETERODIMER AND C/EBPBETA BZIP HOMODIMER BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER 提交 2001-01-10 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 4 PDB 声明:hexameric(6) 与全部聚合物一致
链 C 60–182(123 aa) 片段:RUNT DOMAIN
未记录 AU GOLD ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.6;297 K;0.2 M potassium chloride, 0.01 M magnesium chloride, 0.01 M DTT, 4.5% V/V PEG 8000, 1% V/V glycerol, 1% V/V MPD, 0.05 M MES buffer pH 5.6, pH 5.60, VAPOR DIFFUSION, SITTING DROP, temperature 297K
分辨率 3.00 Å R-free 0.299
2J6W R164N mutant of the RUNX1 Runt domain 提交 2006-10-04 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 46–185(140 aa) 片段:RUNT DOMAIN, RESIDUES 46-185
突变:YES CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.5;22% PEG 8000, 0.1M SODIUM CACODYLATE PH=6.5, 0.2M AMMONIUM SULFATE
分辨率 2.60 Å R-free 0.268
2J6W R164N mutant of the RUNX1 Runt domain 提交 2006-10-04 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 46–185(140 aa) 片段:RUNT DOMAIN, RESIDUES 46-185
突变:YES CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.5;22% PEG 8000, 0.1M SODIUM CACODYLATE PH=6.5, 0.2M AMMONIUM SULFATE
分辨率 2.60 Å R-free 0.268
3WTS Crystal structure of the complex comprised of ETS1, RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 A 60–263(204 aa) 片段:UNP RESIDUES 60-263
突变:L94K 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;298 K;10% PEG 4000, 0.1M AMMONIUM ACETATE, 0.05M TRIS HCL, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.35 Å R-free 0.279
3WTS Crystal structure of the complex comprised of ETS1, RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 F 60–263(204 aa) 片段:UNP RESIDUES 60-263
突变:L94K 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;298 K;10% PEG 4000, 0.1M AMMONIUM ACETATE, 0.05M TRIS HCL, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.35 Å R-free 0.279
3WTT Crystal structure of the complex comprised of phosphorylated ETS1, RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 A 60–263(204 aa) 片段:UNP RESIDUES 60-263
突变:L94K 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;298 K;10% PEG 4000, 0.25M AMMONIUM ACETATE, 0.05M SODIUM ACETATE, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.35 Å R-free 0.277
3WTT Crystal structure of the complex comprised of phosphorylated ETS1, RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 F 60–263(204 aa) 片段:UNP RESIDUES 60-263
突变:L94K 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;298 K;10% PEG 4000, 0.25M AMMONIUM ACETATE, 0.05M SODIUM ACETATE, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.35 Å R-free 0.277
3WTU Crystal structure of the complex comprised of ETS1 (V170A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 A 60–263(204 aa) 片段:UNP RESIDUES 60-263
突变:L94K, V170A 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;4% PEG 8000, 0.1M AMMONIUM ACETATE, 0.02M MAGNESIUM CHLORIDE, 0.05M HEPES, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.70 Å R-free 0.282
3WTU Crystal structure of the complex comprised of ETS1 (V170A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 F 60–263(204 aa) 片段:UNP RESIDUES 60-263
突变:L94K, V170A 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;4% PEG 8000, 0.1M AMMONIUM ACETATE, 0.02M MAGNESIUM CHLORIDE, 0.05M HEPES, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.70 Å R-free 0.282
3WTV Crystal structure of the complex comprised of ETS1(V170G), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 A 60–263(204 aa) 片段:UNP RESIDUES 60-263
突变:L94K, V170G 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;4% PEG 8000, 0.1M AMMONIUM ACETATE, 0.02M MAGNESIUM CHLORIDE, 0.05M HEPES, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.70 Å R-free 0.284
3WTV Crystal structure of the complex comprised of ETS1(V170G), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 F 60–263(204 aa) 片段:UNP RESIDUES 60-263
突变:L94K, V170G 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;4% PEG 8000, 0.1M AMMONIUM ACETATE, 0.02M MAGNESIUM CHLORIDE, 0.05M HEPES, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.70 Å R-free 0.284
3WTW Crystal structure of the complex comprised of ETS1(K167A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 A 60–263(204 aa) 片段:UNP RESIDUES 60-263
突变:L94K, K167A 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6;298 K;12% ISOPROPANOL, 0.02M MAGNESIUM CHLORIDE, 0.05M MES, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.90 Å R-free 0.264
3WTW Crystal structure of the complex comprised of ETS1(K167A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 F 60–263(204 aa) 片段:UNP RESIDUES 60-263
突变:L94K, K167A 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6;298 K;12% ISOPROPANOL, 0.02M MAGNESIUM CHLORIDE, 0.05M MES, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.90 Å R-free 0.264
3WTX Crystal structure of the complex comprised of ETS1(Y329A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 A 60–263(204 aa) 片段:UNP RESIDUES 60-263
突变:L94K 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.8;298 K;10% PEG 4000, 0.25M AMMONIUM ACETATE, 0.05M SODIUM ACETATE PH5.8, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.80 Å R-free 0.271
3WTX Crystal structure of the complex comprised of ETS1(Y329A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 F 60–263(204 aa) 片段:UNP RESIDUES 60-263
突变:L94K 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.8;298 K;10% PEG 4000, 0.25M AMMONIUM ACETATE, 0.05M SODIUM ACETATE PH5.8, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.80 Å R-free 0.271
3WTY Crystal structure of the complex comprised of ETS1(G333P), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 A 60–263(204 aa) 片段:UNP RESIDUES 60-263
突变:L94K 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.8;298 K;4% PEG 4000, 0.25M AMMONIUM ACETATE, 0.05M SODIUM ACETATE, pH 5.8, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.70 Å R-free 0.268
3WTY Crystal structure of the complex comprised of ETS1(G333P), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 F 60–263(204 aa) 片段:UNP RESIDUES 60-263
突变:L94K 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.8;298 K;4% PEG 4000, 0.25M AMMONIUM ACETATE, 0.05M SODIUM ACETATE, pH 5.8, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.70 Å R-free 0.268
3WU1 Crystal structure of the ETS1-RUNX1-DNA ternary complex 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 2 PDB 声明:tetrameric(4) 与全部聚合物一致
链 A 55–177(123 aa) 片段:UNP RESIDUES 55-177
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 7.5;298 K;11% PEG MME 550, 0.1M KCL, 0.015M MGCL2, 0.05M TRIS, pH 7.5, VAPOR DIFFUSION, temperature 298K
分辨率 2.40 Å R-free 0.249
4L0Y Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 1) 提交 2013-06-01 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 2 PDB 声明:tetrameric(4) 与全部聚合物一致
链 A 1–242(242 aa) 片段:UNP residues 1-242
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 5.6;298 K;Plate-shaped crystals grown from 100 mM potassium chloride, 15 mM magnesium chloride hexahydrate, 25 mM MES, pH 5.6, 14% v/v PEG550 MME, 6% v/v glycerol, crystal size improved by macroseeding, VAPOR DIFFUSION, temperature 298K
分辨率 2.50 Å R-free 0.245
4L0Z Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 2) 提交 2013-06-01 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 2 PDB 声明:tetrameric(4) 与全部聚合物一致
链 A 1–242(242 aa) 片段:UNP residues 1-242
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.6;298 K;Square bipyramid-shaped crystals grown from 100 mM potassium chloride, 15 mM magnesium chloride hexahydrate, 25 mM MES, pH 5.6, 14% v/v PEG550 MME, 6% v/v glycerol, crystal size improved by macroseeding, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.70 Å R-free 0.272
4L18 Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 3) 提交 2013-06-02 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 2 PDB 声明:tetrameric(4) 与全部聚合物一致
链 A 48–214(167 aa) 片段:UNP residues 48-214
未记录 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.6;298 K;2.5% w/v PEG4000, 5 mM magnesium chloride hexahydrate, 25 mM MES, pH 5.6, 5% v/v glycerol, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.30 Å R-free 0.280
4L18 Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 3) 提交 2013-06-02 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 2 PDB 声明:tetrameric(4) 与全部聚合物一致
链 E 48–214(167 aa) 片段:UNP residues 48-214
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.6;298 K;2.5% w/v PEG4000, 5 mM magnesium chloride hexahydrate, 25 mM MES, pH 5.6, 5% v/v glycerol, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.30 Å R-free 0.280