← Back to search

Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q04760 New Search
16PDB entries
21Biological assembly
42chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1BH5 HUMAN GLYOXALASE I Q33E, E172Q DOUBLE MUTANT Deposited 1998-06-13 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–183（183 aa）
Chain B 1–183（183 aa）
Mutation：Q33E, E172Q Mutation：Q33E, E172Q ZN ZINC ION × 2 GTX S-HEXYLGLUTATHIONE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；PROTEIN WAS CRYSTALLISED FROM PEG 2000 MONOMETHLY ETHER 50 MM MES PH 5.8, 0.1M NACL
Resolution 2.20 Å R-free 0.250
1BH5 HUMAN GLYOXALASE I Q33E, E172Q DOUBLE MUTANT Deposited 1998-06-13 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 1–183（183 aa）
Chain D 1–183（183 aa）
Mutation：Q33E, E172Q Mutation：Q33E, E172Q ZN ZINC ION × 2 GTX S-HEXYLGLUTATHIONE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；PROTEIN WAS CRYSTALLISED FROM PEG 2000 MONOMETHLY ETHER 50 MM MES PH 5.8, 0.1M NACL
Resolution 2.20 Å R-free 0.250
1FRO HUMAN GLYOXALASE I WITH BENZYL-GLUTATHIONE INHIBITOR Deposited 1997-02-25 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2–184（183 aa）
Chain B 2–184（183 aa）
Not recorded ZN ZINC ION × 2 GSB S-BENZYL-GLUTATHIONE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；pH 5.8
Resolution 2.20 Å R-free 0.234
1FRO HUMAN GLYOXALASE I WITH BENZYL-GLUTATHIONE INHIBITOR Deposited 1997-02-25 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 2–184（183 aa）
Chain D 2–184（183 aa）
Not recorded ZN ZINC ION × 2 GSB S-BENZYL-GLUTATHIONE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；pH 5.8
Resolution 2.20 Å R-free 0.234
1QIN HUMAN GLYOXALASE I COMPLEXED WITH S-(N-HYDROXY-N-P-IODOPHENYLCARBAMOYL) GLUTATHIONE Deposited 1999-06-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–183（183 aa）
Chain B 1–183（183 aa）
Not recorded ZN ZINC ION × 2 GIP S-(N-HYDROXY-N-IODOPHENYLCARBAMOYL)GLUTATHIONE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；PROTEIN WAS CRYSTALLISED BY EQILLABRATION AGAINST PEG 2000 MONOMETHLY ETHER, 50 MM MES PH 5.8, 0.1M NACL. HIPC-GSH WAS PRESENT IN THE PROTEIN SOLUTION
Resolution 2.00 Å R-free 0.210
1QIP HUMAN GLYOXALASE I COMPLEXED WITH S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE Deposited 1999-06-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–183（183 aa）
Chain B 1–183（183 aa）
Not recorded ZN ZINC ION × 2 GNB S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE × 2 BME BETA-MERCAPTOETHANOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；PROTEIN WAS CRYSTALLISED BY EQILLABRATION AGAINST PEG 2000 MONOMETHLY ETHER, 50 MM MES PH 5.8, 0.1M NACL THEN SOAKED IN 10MM NBC-GSH
Resolution 1.72 Å R-free 0.210
1QIP HUMAN GLYOXALASE I COMPLEXED WITH S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE Deposited 1999-06-14 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 1–183（183 aa）
Chain D 1–183（183 aa）
Not recorded ZN ZINC ION × 2 GNB S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE × 2 BME BETA-MERCAPTOETHANOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；PROTEIN WAS CRYSTALLISED BY EQILLABRATION AGAINST PEG 2000 MONOMETHLY ETHER, 50 MM MES PH 5.8, 0.1M NACL THEN SOAKED IN 10MM NBC-GSH
Resolution 1.72 Å R-free 0.210
3VW9 Human Glyoxalase I with an N-hydroxypyridone inhibitor Deposited 2012-08-10 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–184（184 aa）
Chain B 1–184（184 aa）
Not recorded ZN ZINC ION × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 HPJ 1-hydroxy-6-[1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-4-phenylpyridin-2(1H)-one × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；25%(w/v) PEG 2000 MME, 10%(v/v) Glycerol, 0.1M Na-HEPES (pH 7.0), vapor diffusion, hanging drop, temperature 293K
Resolution 1.47 Å R-free 0.193
3W0T Human Glyoxalase I with an N-hydroxypyridone derivative inhibitor Deposited 2012-11-02 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–184（184 aa）
Chain B 1–184（184 aa）
Not recorded ZN ZINC ION × 2 HPU N-[3-(1-hydroxy-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)phenyl]methanesulfonamide × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；33% (w/v) PEG 2000 MME, 0.1M Na-HEPES (pH 7.0), vapor diffusion, hanging drop, temperature 293K
Resolution 1.35 Å R-free 0.197
3W0T Human Glyoxalase I with an N-hydroxypyridone derivative inhibitor Deposited 2012-11-02 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 1–184（184 aa）
Chain D 1–184（184 aa）
Not recorded ZN ZINC ION × 2 HPU N-[3-(1-hydroxy-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)phenyl]methanesulfonamide × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；33% (w/v) PEG 2000 MME, 0.1M Na-HEPES (pH 7.0), vapor diffusion, hanging drop, temperature 293K
Resolution 1.35 Å R-free 0.197
3W0U human Glyoxalase I with an N-hydroxypyridone inhibitor Deposited 2012-11-02 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–184（184 aa）
Chain B 1–184（184 aa）
Not recorded ZN ZINC ION × 2 HPW N-[3-(1-Hydroxy-6-oxo-4-phenyl-1,6-dihydro-pyridin-2-yl)-5-methanesulfonylamino-phenyl]-methanesulfonamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；25% (w/v) PEG 2000 MME, 10%(v/v) Glycerol, 0.1M Na-HEPES (pH 7.0), vapor diffusion, hanging drop, temperature 293K
Resolution 1.70 Å R-free 0.242
7WSZ human glyoxalase I (with C-ter His tag) in glycerol-bound form Deposited 2022-02-03 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–184（184 aa）
Chain B 1–184（184 aa）
Not recorded ZN ZINC ION × 2 GOL GLYCEROL × 4 BO3 BORIC ACID × 3 IMD IMIDAZOLE × 1 BME BETA-MERCAPTOETHANOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M MIB (sodium malonate, imidazole, and boric acid), 25% PEG1500
Resolution 1.52 Å R-free 0.187
7WT0 human glyoxalase I (with C-ter His tag) in complex with TLSC702 Deposited 2022-02-03 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–184（184 aa）
Chain B 1–184（184 aa）
Not recorded ZN ZINC ION × 2 5ZO (~{E})-3-(1,3-benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acid × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M MgCl2, 0.1 M Bis-Tris, 25% PEG3350
Resolution 2.00 Å R-free 0.222
7WT1 human glyoxalase I (with C-ter His tag) in inhibitor-free form Deposited 2022-02-03 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–184（184 aa）
Chain B 1–184（184 aa）
Not recorded ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M NaCl, 0.1 M MES-NaOH, 25% PEG3350
Resolution 1.85 Å R-free 0.230
7WT2 human glyoxalase I in complex with TLSC702 Deposited 2022-02-03 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–184（184 aa）
Chain B 1–184（184 aa）
Not recorded ZN ZINC ION × 2 5ZO (~{E})-3-(1,3-benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acid × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M NaCl, 0.1 M Bis-Tris, 25% PEG3350
Resolution 2.00 Å R-free 0.228
9KEE human glyoxalase I (with C-ter His tag) in complex with licochalcone B, form 1 Deposited 2024-11-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–184（184 aa）
Chain B 1–184（184 aa）
Not recorded ZN ZINC ION × 2 A1L5R 1-(4-hydroxyphenyl)-3-[2-methoxy-3,4-bis(oxidanyl)phenyl]prop-2-en-1-one × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.2 M Sodium chloride, 0.1 M Bis-Tris, 25%(w/v) PEG 3350
Resolution 2.08 Å R-free 0.234
9KEG human glyoxalase I (with C-ter His tag) in complex with licochalcone B, form 2 Deposited 2024-11-05 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–184（184 aa）
Chain B 1–184（184 aa）
Not recorded A1L5R 1-(4-hydroxyphenyl)-3-[2-methoxy-3,4-bis(oxidanyl)phenyl]prop-2-en-1-one × 2 PG4 TETRAETHYLENE GLYCOL × 2 BME BETA-MERCAPTOETHANOL × 3 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.8；293 K；0.2 M Sodium chloride, 0.1 M MES, 25%(w/v) PEG 3350
Resolution 1.80 Å R-free 0.239
9KEH human glyoxalase I (with C-ter His tag) in complex with licochalcone B and GSH, form 3 Deposited 2024-11-05 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–184（184 aa）
Chain B 1–184（184 aa）
Not recorded ZN ZINC ION × 2 A1L5R 1-(4-hydroxyphenyl)-3-[2-methoxy-3,4-bis(oxidanyl)phenyl]prop-2-en-1-one × 2 PG4 TETRAETHYLENE GLYCOL × 2 GSH Glutathione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.2 M Sodium chloride, 0.1 M Bis-Tris, 25%(w/v) PEG 3350
Resolution 1.72 Å R-free 0.193
9KEI human glyoxalase I (with C-ter His tag) in complex with licochalcone B, form 4 Deposited 2024-11-05 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–184（184 aa）
Chain B 1–184（184 aa）
Not recorded A1L5R 1-(4-hydroxyphenyl)-3-[2-methoxy-3,4-bis(oxidanyl)phenyl]prop-2-en-1-one × 2 PGE TRIETHYLENE GLYCOL × 2 ZN ZINC ION × 2 BME BETA-MERCAPTOETHANOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.8；293 K；0.2 M Sodium chloride, 0.1 M MES, 25%(w/v) PEG 3350
Resolution 1.81 Å R-free 0.238
9KEK human glyoxalase I (with C-ter His tag) in complex with piceatannol Deposited 2024-11-05 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–184（184 aa）
Chain B 1–184（184 aa）
Not recorded ZN ZINC ION × 2 PIT PICEATANNOL × 2 PG4 TETRAETHYLENE GLYCOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.2 M Sodium chloride, 0.1 M Bis-Tris, 25%(w/v) PEG 3350
Resolution 2.11 Å R-free 0.233
9KEK human glyoxalase I (with C-ter His tag) in complex with piceatannol Deposited 2024-11-05 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 1–184（184 aa）
Chain D 1–184（184 aa）
Not recorded ZN ZINC ION × 2 PIT PICEATANNOL × 1 PG4 TETRAETHYLENE GLYCOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.2 M Sodium chloride, 0.1 M Bis-Tris, 25%(w/v) PEG 3350
Resolution 2.11 Å R-free 0.233

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.