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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q80WG5 New Search
36PDB entries
36Biological assembly
225chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
6FNW Structure of a volume-regulated anion channel of the LRRC8 family Deposited 2018-02-05 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 398–810（413 aa）
Not recorded EDO 1,2-ETHANEDIOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；277.15 K；22% PEG 3350, 0.2M Na/K tartrate, 0.1M Bis-Tris propane pH 8.5
Resolution 1.80 Å R-free 0.208
6G8Z Structure of the pore domain of homomeric mLRRC8A volume-regulated anion channel at 3.66 A resolution Deposited 2018-04-10 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–810（810 aa）
Chain B 1–810（810 aa）
Chain C 1–810（810 aa）
Chain D 1–810（810 aa）
Chain E 1–810（810 aa）
Chain F 1–810（810 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.66 Å
6G9L Structure of homomeric mLRRC8A volume-regulated anion channel at 5.01 A resolution Deposited 2018-04-11 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–810（810 aa）
Chain B 1–810（810 aa）
Chain C 1–810（810 aa）
Chain D 1–810（810 aa）
Chain E 1–810（810 aa）
Chain F 1–810（810 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.01 Å
6G9O Structure of full-length homomeric mLRRC8A volume-regulated anion channel at 4.25 A resolution Deposited 2018-04-11 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–810（810 aa）
Chain B 1–810（810 aa）
Chain C 1–810（810 aa）
Chain D 1–810（810 aa）
Chain E 1–810（810 aa）
Chain F 1–810（810 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.25 Å
6NZW LRRC8A-DCPIB in MSP1E3D1 nanodisc constricted state Deposited 2019-02-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–810（810 aa）
Chain B 1–810（810 aa）
Chain C 1–810（810 aa）
Chain D 1–810（810 aa）
Chain E 1–810（810 aa）
Chain F 1–810（810 aa）
Not recorded POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 18 L9Y 4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic acid × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；3 microliter drop size, 3 second blot time
Resolution 3.21 Å
6NZZ LRRC8A-DCPIB in MSP1E3D1 nanodisc expanded state Deposited 2019-02-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–810（810 aa）
Chain B 1–810（810 aa）
Chain C 1–810（810 aa）
Chain D 1–810（810 aa）
Chain E 1–810（810 aa）
Chain F 1–810（810 aa）
Not recorded POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 18 L9Y 4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic acid × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；3 microliter drop size, 3 second blot time
Resolution 3.32 Å
6O00 apo-LRRC8A in MSP2N2 nanodisc constricted state Deposited 2019-02-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–810（810 aa）
Chain B 1–810（810 aa）
Chain C 1–810（810 aa）
Chain D 1–810（810 aa）
Chain E 1–810（810 aa）
Chain F 1–810（810 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；3 microliter drop size, 3 second blot time
Resolution 4.18 Å
7M17 SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-1) Deposited 2021-03-12 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–810（810 aa）
Chain B 1–810（810 aa）
Chain C 1–810（810 aa）
Chain D 1–810（810 aa）
Chain E 1–810（810 aa）
Chain F 1–810（810 aa）
Not recorded PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 18 YNJ 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；pH to 7.4 with KOH
cryo-EM vitrification conditions Cryogen ETHANE；2 microliter drop size, manual wait time of 2 seconds, blot force of 1, 3 second blot time
Resolution 3.65 Å
7M19 SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-2) Deposited 2021-03-12 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–810（810 aa）
Chain B 1–810（810 aa）
Chain C 1–810（810 aa）
Chain D 1–810（810 aa）
Chain E 1–810（810 aa）
Chain F 1–810（810 aa）
Not recorded PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 18 YNJ 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；pH to 7.4 with KOH
cryo-EM vitrification conditions Cryogen ETHANE；2 microliter drop size, manual wait time of 2 seconds, blot force of 1, 3 second blot time
Resolution 3.69 Å
7P5V Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1 Deposited 2021-07-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 15–808（794 aa）
Chain B 15–808（794 aa）
Chain C 15–808（794 aa）
Chain D 15–808（794 aa）
Chain E 15–808（794 aa）
Chain F 15–808（794 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.06 Å
7P5W Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb2 Deposited 2021-07-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 15–808（794 aa）
Chain B 15–808（794 aa）
Chain C 15–808（794 aa）
Chain D 15–808（794 aa）
Chain E 15–808（794 aa）
Chain F 15–808（794 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.50 Å
7P5Y Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb3 Deposited 2021-07-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 15–808（794 aa）
Chain B 15–808（794 aa）
Chain C 15–808（794 aa）
Chain D 15–808（794 aa）
Chain E 15–808（794 aa）
Chain F 15–808（794 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.29 Å
7P60 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb4 at 1:0.5 ratio Deposited 2021-07-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count
Chain A 1–810（810 aa）
Chain B 1–810（810 aa）
Chain C 1–810（810 aa）
Chain D 1–810（810 aa）
Chain E 1–810（810 aa）
Chain F 1–810（810 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.80 Å
7P6K Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb5 Deposited 2021-07-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count
Chain A 1–810（810 aa）
Chain B 1–810（810 aa）
Chain C 1–810（810 aa）
Chain D 1–810（810 aa）
Chain E 1–810（810 aa）
Chain F 1–810（810 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.80 Å
8B41 Structure of heteromeric LRRC8A/C (1:1 co-transfected) Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1 Deposited 2022-09-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain A 2–810（809 aa）
Chain B 2–810（809 aa）
Chain C 2–810（809 aa）
Chain D 2–810（809 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.80 Å
8B42 Structure of heteromeric LRRC8A/C Volume-Regulated Anion Channel. Deposited 2022-09-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 2–810（809 aa）
Chain B 2–810（809 aa）
Chain C 2–810（809 aa）
Chain D 2–810（809 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 6.60 Å
8DR8 LRRC8A:C conformation 2 (oblong) top mask Deposited 2022-07-20 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–71（71 aa）
Chain A 91–810（720 aa）
Chain B 1–71（71 aa）
Chain B 91–810（720 aa）
Chain C 1–71（71 aa）
Chain C 91–810（720 aa）
Chain D 1–71（71 aa）
Chain D 91–810（720 aa）
Chain E 1–71（71 aa）
Chain E 91–810（720 aa）
Not recorded PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 20 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.04 Å
8DRA LRRC8A:C conformation 2 (oblong) LRR mask Deposited 2022-07-20 Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–71（71 aa）
Chain A 91–810（720 aa）
Chain B 1–71（71 aa）
Chain B 91–810（720 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.98 Å
8DRE LRRC8A:C conformation 2 (oblong) Deposited 2022-07-20 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–71（71 aa）
Chain A 91–810（720 aa）
Chain B 1–71（71 aa）
Chain B 91–810（720 aa）
Chain C 1–71（71 aa）
Chain C 91–810（720 aa）
Chain D 1–71（71 aa）
Chain D 91–810（720 aa）
Chain E 1–71（71 aa）
Chain E 91–810（720 aa）
Not recorded PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 20 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.18 Å
8DRK LRRC8A:C conformation 1 (round) top focus Deposited 2022-07-21 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–71（71 aa）
Chain A 91–810（720 aa）
Chain B 1–71（71 aa）
Chain B 91–810（720 aa）
Chain C 1–71（71 aa）
Chain C 91–810（720 aa）
Chain D 1–71（71 aa）
Chain D 91–810（720 aa）
Chain E 1–71（71 aa）
Chain E 91–810（720 aa）
Not recorded PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 21 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.95 Å
8DRN LRRC8A:C conformation 1 (round) LRR focus 1 Deposited 2022-07-21 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–71（71 aa）
Chain A 91–810（720 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.12 Å
8DRO LRRC8A:C conformation 1 (round) LRR focus 2 Deposited 2022-07-21 Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 1–71（71 aa）
Chain B 91–810（720 aa）
Chain C 1–71（71 aa）
Chain C 91–810（720 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.06 Å
8DRQ LRRC8A:C conformation 1 (round) LRR focus 3 Deposited 2022-07-21 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain E 1–71（71 aa）
Chain E 91–810（720 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.16 Å
8DS3 LRRC8A:C conformation 1 (round) Deposited 2022-07-21 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–71（71 aa）
Chain A 91–810（720 aa）
Chain B 1–71（71 aa）
Chain B 91–810（720 aa）
Chain C 1–71（71 aa）
Chain C 91–810（720 aa）
Chain D 1–71（71 aa）
Chain D 91–810（720 aa）
Chain E 1–71（71 aa）
Chain E 91–810（720 aa）
Not recorded PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 21 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.07 Å
8DS9 LRRC8A:C in MSPE3D1 nanodisc top focus Deposited 2022-07-21 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–71（71 aa）
Chain A 91–810（720 aa）
Chain B 1–71（71 aa）
Chain B 91–810（720 aa）
Chain C 1–71（71 aa）
Chain C 91–810（720 aa）
Chain D 1–71（71 aa）
Chain D 91–810（720 aa）
Chain E 1–71（71 aa）
Chain E 91–810（720 aa）
Not recorded PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.17 Å
8DSA LRRC8A:C in MSP1E3D1 nanodisc Deposited 2022-07-21 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–71（71 aa）
Chain A 91–810（720 aa）
Chain B 1–71（71 aa）
Chain B 91–810（720 aa）
Chain C 1–71（71 aa）
Chain C 91–810（720 aa）
Chain D 1–71（71 aa）
Chain D 91–810（720 aa）
Chain E 1–71（71 aa）
Chain E 91–810（720 aa）
Not recorded PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.48 Å
8F74 LRRC8A(T48D):C conformation 2 top focus Deposited 2022-11-18 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–76（76 aa）
Chain A 92–810（719 aa）
Chain B 1–76（76 aa）
Chain B 92–810（719 aa）
Chain C 1–76（76 aa）
Chain C 92–810（719 aa）
Chain D 1–76（76 aa）
Chain D 92–810（719 aa）
Chain E 1–76（76 aa）
Chain E 92–810（719 aa）
Not recorded PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8F75 LRRC8A(T48D):C conformation 2 LRR focus Deposited 2022-11-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 91–810（720 aa）
Chain B 91–810（720 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
8F77 LRRC8A(T48D):C conformation 2 top focus Deposited 2022-11-18 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–76（76 aa）
Chain A 90–810（721 aa）
Chain B 1–76（76 aa）
Chain B 90–810（721 aa）
Chain C 1–76（76 aa）
Chain C 90–810（721 aa）
Chain D 1–76（76 aa）
Chain D 90–810（721 aa）
Chain E 1–76（76 aa）
Chain E 90–810（721 aa）
Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.15 Å
8F79 LRRC8A(T48D):C conformation 2 top focus Deposited 2022-11-18 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–76（76 aa）
Chain A 90–810（721 aa）
Chain B 1–76（76 aa）
Chain B 90–810（721 aa）
Chain C 1–76（76 aa）
Chain C 90–810（721 aa）
Chain D 1–76（76 aa）
Chain D 90–810（721 aa）
Chain E 1–76（76 aa）
Chain E 90–810（721 aa）
Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 17 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.15 Å
8F7B LRRC8A(T48D):C conformation 2 top focus Deposited 2022-11-18 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–76（76 aa）
Chain A 90–810（721 aa）
Chain B 1–76（76 aa）
Chain B 90–810（721 aa）
Chain C 1–76（76 aa）
Chain C 90–810（721 aa）
Chain D 1–76（76 aa）
Chain D 90–810（721 aa）
Chain E 1–76（76 aa）
Chain E 90–810（721 aa）
Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 17 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.15 Å
8F7D LRRC8A(T48D):C conformation 2 top focus Deposited 2022-11-18 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–76（76 aa）
Chain A 90–810（721 aa）
Mutation：T48D Mutation：T48D No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.20 Å
8F7E LRRC8A(T48D):C conformation 2 top focus Deposited 2022-11-18 Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 1–76（76 aa）
Chain B 90–810（721 aa）
Chain C 1–76（76 aa）
Chain C 90–810（721 aa）
Mutation：T48D Mutation：T48D Mutation：T48D Mutation：T48D No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.13 Å
8F7J LRRC8A(T48D):C conformation 2 top focus Deposited 2022-11-18 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain E 1–76（76 aa）
Chain E 90–810（721 aa）
Mutation：T48D Mutation：T48D No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.32 Å
9DX7 LRRC8A:D Conformation 1 Deposited 2024-10-10 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–76（76 aa）
Chain A 91–810（720 aa）
Chain B 1–76（76 aa）
Chain B 91–810（720 aa）
Chain C 1–76（76 aa）
Chain C 91–810（720 aa）
Chain D 1–76（76 aa）
Chain D 91–810（720 aa）
Not recorded PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 18 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
9DXA LRRC8A:D Conformation 2 Deposited 2024-10-11 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–76（76 aa）
Chain A 91–810（720 aa）
Chain B 1–76（76 aa）
Chain B 91–810（720 aa）
Chain C 1–76（76 aa）
Chain C 91–810（720 aa）
Chain D 1–76（76 aa）
Chain D 91–810（720 aa）
Not recorded PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 18 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.