Current Protein Identity：Q9Y2M0
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 4REA A Nuclease DNA complex Deposited 2014-09-22 | Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: pentameric（5） Consistent with all polymers |
Chain A
373–1017（645 aa）
Fragment：UNP residues 373-1017
Chain B
373–1017（645 aa）
Fragment：UNP residues 373-1017
|
Mutation：D960A Mutation：D960A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
micro-batch under oil；300 K；0.1-0.2M KSCN, 18-22% PEG 3350, 0.1M BisTris-propane, micro-batch under oil, temperature 300K
|
Resolution 3.81 Å R-free 0.277 |
| 4REB Structural Insights into 5' Flap DNA Unwinding and Incision by the Human FAN1 Dimer Deposited 2014-09-22 | Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: pentameric（5） Consistent with all polymers |
Chain A
373–1017（645 aa）
Fragment：UNP residues 373-1017
Chain H
373–1017（645 aa）
Fragment：UNP residues 373-1017
|
Mutation：D960A Mutation：D960A | SM SAMARIUM (III) ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
micro-batch under oil；300 K；0.1mM spermidine, 1% 1,6-Hexanediol, 22-24% PEG 3350, 0.1M BisTris Propane, micro-batch under oil, temperature 300K
|
Resolution 4.20 Å R-free 0.262 |
| 4REC A nuclease-DNA complex form 3 Deposited 2014-09-22 | Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
373–1017（645 aa）
Fragment：UNP residues 373-1017
|
Mutation：D960A | IOD IODIDE ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
micro-batch under oil；300 K；0.1M potassium iodide, 0.1mM spermidine, 18% PEG3350, 0.1M BisTris propane, micro-batch under oil, temperature 300K
|
Resolution 2.20 Å R-free 0.254 |
| 4RI8 FAN1 Nuclease bound to 5' phosphorylated p(dG)/3'(dT-dT-dT-dT) double flap DNA Deposited 2014-10-05 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain A
370–1017（648 aa）
Fragment：unp residues 370-1017
|
Mutation：V487A | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；PEG 3350, NaCl, pH 7.0, hanging drop vapor diffusion, temperature 277K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 2.90 Å R-free 0.255 |
| 4RI8 FAN1 Nuclease bound to 5' phosphorylated p(dG)/3'(dT-dT-dT-dT) double flap DNA Deposited 2014-10-05 | Assembly 2 Protein–DNA Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain B
370–1017（648 aa）
Fragment：unp residues 370-1017
|
Mutation：V487A | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；PEG 3350, NaCl, pH 7.0, hanging drop vapor diffusion, temperature 277K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 2.90 Å R-free 0.255 |
| 4RI9 FAN1 Nuclease bound to 5' phosphorylated p(dT)/3'(dT-dT-dT-dT-dT-dT-dT-dT) double flap DNA Deposited 2014-10-05 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: pentameric（5） Consistent with all polymers |
Chain A
370–1017（648 aa）
Fragment：unp residues 370-1017
|
Mutation：V487A | BA BARIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；PEG 3350, NaCl, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.90 Å R-free 0.266 |
| 4RI9 FAN1 Nuclease bound to 5' phosphorylated p(dT)/3'(dT-dT-dT-dT-dT-dT-dT-dT) double flap DNA Deposited 2014-10-05 | Assembly 2 Protein–DNA Monomer；Protein × 1 PDB declaration: pentameric（5） Consistent with all polymers |
Chain B
370–1017（648 aa）
Fragment：unp residues 370-1017
|
Mutation：V487A | BA BARIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；PEG 3350, NaCl, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.90 Å R-free 0.266 |
| 4RIA FAN1 Nuclease bound to 5' phosphorylated nicked DNA Deposited 2014-10-05 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: pentameric（5） Consistent with all polymers |
Chain A
370–1017（648 aa）
Fragment：unp residues 370-1017
|
Not recorded | BA BARIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；PEG 3350, NaCl , pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.00 Å R-free 0.267 |
| 4RIA FAN1 Nuclease bound to 5' phosphorylated nicked DNA Deposited 2014-10-05 | Assembly 2 Protein–DNA Monomer；Protein × 1 PDB declaration: pentameric（5） Consistent with all polymers |
Chain B
370–1017（648 aa）
Fragment：unp residues 370-1017
|
Not recorded | BA BARIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；PEG 3350, NaCl , pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.00 Å R-free 0.267 |
| 4RIB FAN1 Nuclease bound to 5' phosphorylated p(dT) single flap DNA Deposited 2014-10-05 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain A
364–1017（654 aa）
Fragment：unp residues 364-1017
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
hanging drop vapor diffusion；pH 7；277 K；PEG 3350, NaCl, pH 7.0, hanging drop vapor diffusion, temperature 277K
|
Resolution 3.25 Å R-free 0.265 |
| 4RIB FAN1 Nuclease bound to 5' phosphorylated p(dT) single flap DNA Deposited 2014-10-05 | Assembly 2 Protein–DNA Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain B
364–1017（654 aa）
Fragment：unp residues 364-1017
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
hanging drop vapor diffusion；pH 7；277 K；PEG 3350, NaCl, pH 7.0, hanging drop vapor diffusion, temperature 277K
|
Resolution 3.25 Å R-free 0.265 |
| 4RIC FAN1 Nuclease bound to 5' hydroxyl (dT-dT) single flap DNA Deposited 2014-10-05 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain A
370–1009（640 aa）
Fragment：unp residues 370-1009
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；PEG 3350, NaCl , pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.257 |
| 4RIC FAN1 Nuclease bound to 5' hydroxyl (dT-dT) single flap DNA Deposited 2014-10-05 | Assembly 2 Protein–DNA Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain B
370–1009（640 aa）
Fragment：unp residues 370-1009
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；PEG 3350, NaCl , pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.257 |
| 4RID Human FAN1 nuclease Deposited 2014-10-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
370–1009（640 aa）
Fragment：unp residues 370-1009
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；PEG 3350, NaCl, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.30 Å R-free 0.288 |
| 4RID Human FAN1 nuclease Deposited 2014-10-05 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
370–1009（640 aa）
Fragment：unp residues 370-1009
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；PEG 3350, NaCl, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.30 Å R-free 0.288 |
| 4RID Human FAN1 nuclease Deposited 2014-10-05 | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
370–1009（640 aa）
Fragment：unp residues 370-1009
Chain B
370–1009（640 aa）
Fragment：unp residues 370-1009
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；PEG 3350, NaCl, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.30 Å R-free 0.288 |
| 4RY3 Crystal structure of human Fanconi-associated nuclease 1 Deposited 2014-12-13 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
371–1010（640 aa）
Fragment：UNP residues 371-1010
|
Not recorded | PT PLATINUM (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.2；277 K；2.5M sodium acetate, 0.1M Bis-Tris propane, 10% glycerol, pH 8.2, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.243 |
| 4RY3 Crystal structure of human Fanconi-associated nuclease 1 Deposited 2014-12-13 | Assembly 2 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
371–1010（640 aa）
Fragment：UNP residues 371-1010
|
Not recorded | PT PLATINUM (II) ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.2；277 K；2.5M sodium acetate, 0.1M Bis-Tris propane, 10% glycerol, pH 8.2, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.243 |
| 8S5A The crystal structure of FAN1 Nuclease bound to 5' phosphorylated p(dG)/3'(dT-dT-dT-dT) double flap DNA Deposited 2024-02-23 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain A
364–1017（654 aa）
|
Not recorded | CA CALCIUM ION × 2 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.1 M Hepes/MOPS pH: 7.25, 0.1M Sodium formate 0.1M Ammonium acetate 0.1M Sodium citrate tribasic dihydrate 0.1M Potassium sodium tartrate tetrahydrate 0.1M Sodium oxamate
21% v/v Ethylene glycol 21 % w/v PEG 8000
|
Resolution 2.65 Å R-free 0.273 |
| 9CG4 Cryo-EM structure of FAN1, PCNA and DNA substrate with (CAG)2 extrusion in intermediate state Deposited 2024-06-28 | Assembly 1 Protein–DNA Heteromer；Protein × 4 PDB declaration: hexameric（6） Consistent with all polymers |
Chain E
372–554（183 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.37 Å |
| 9CHM Cryo-EM structure of FAN1 R507H and PCNA in intermediate state Deposited 2024-07-01 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain E
372–555（184 aa）
|
Mutation：R507H | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.47 Å |
| 9CL7 Cryo-EM structure of FAN1-PCNA-DNA in final state Deposited 2024-07-10 | Assembly 1 Protein–DNA Heteromer；Protein × 4 PDB declaration: hexameric（6） Consistent with all polymers |
Chain E
372–1010（639 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.83 Å |
| 9CMA Cryo-EM structure of FAN1 R507H-PCNA-DNA in final state Deposited 2024-07-13 | Assembly 1 Protein–DNA Heteromer；Protein × 4 PDB declaration: hexameric（6） Consistent with all polymers |
Chain A
372–1017（646 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.97 Å |
| 9EO1 Cryo_EM structure of human FAN1 in complex with 5' flap DNA substrate Deposited 2024-03-14 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain A
372–1007（636 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE
|
Resolution 3.20 Å |
| 9EOA Cryo_EM structure of human FAN1 in complex with 5' flap DNA substrate and PCNA Deposited 2024-03-14 | Assembly 1 Protein–DNA Heteromer；Protein × 4 PDB declaration: heptameric（7） Consistent with all polymers |
Chain A
372–1007（636 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE
|
Resolution 3.27 Å |
| 9GY0 Cryo_EM structure of human FAN1 R507H mutant in complex with 5' flap DNA substrate and PCNA Deposited 2024-10-01 | Assembly 1 Protein–DNA Heteromer；Protein × 4 PDB declaration: heptameric（7） Consistent with all polymers |
Chain A
1–1017（1017 aa）
|
Not recorded | CA CALCIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE
|
Resolution 3.42 Å |