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10px

;Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with benzoxaborole derivative of azithromycin (AZI-BB2), mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution ;

Method: X-RAY DIFFRACTION Dmax: 367.7 Å Quality: EXCELLENT

SAXS Profile

SAXS profile for 10px

P(r) Distribution

P(r) distribution for 10px
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1. Structure Basics

entry_id10px
deposition_date2026-02-01
title;Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with benzoxaborole derivative of azithromycin (AZI-BB2), mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution ;
keywordsMacrolides, azithromycin, benzoxaboroles, ribosome, translation, inhibition, antibiotic, drug resistance; RIBOSOME
methodX-RAY DIFFRACTION
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Download Data

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2. SAXS Parameters (CRYSOL)

rg_guinier— Å
rg_electron134.00 Å
i0901510000000.00
molecular_weight4206900.0 kDa
excluded_volume3439200 ų
envelope_volume8345100 ų
shell_volume505310 ų
envelope_diameter469.1 Å
shell_rg126.50 Å
envelope_rg131.90 Å
shape_rg134.20 Å
total_rg133.70 Å
total_atoms296041
n_residues20873
n_harmonics20
q_range— – 0.5000 Å−1
n_points101
shell_typedirectional
solvent_density0.3340 e/ų
contrast_shell0.0300 e/ų
crysol_version4.1.3
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3. P(r) Analysis (GNOM)

dmax367.7 Å
rg_real127.20 Å
rg_real_error1.61 Å
i0_real8.6620e+11
i0_real_error2.1440e+10
rg_reciprocal117.70 Å
i0_reciprocal850400000000.0000
total_estimate0.9078
solution_quality EXCELLENT a EXCELLENT solution
n_peaks1
r_peak_primary133.7 Å
skewness0.360
kurtosis-0.715
angular_range— – 0.0550 Å−1
current_alpha0.8190
highest_alpha14010000000.0000
n_real_points12
gnom_version4.1.3
quality_criteria AN1: 0.002; Oscil: 0.979; Stabil: 0.977; Sysdev: 1.000; Positv: 1.000; Valcen: 0.939; Smooth: 0.000
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4. Crystallography & Experiment

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5. Entities & Polymer Info (62)

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6. Citations (1)

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7. Files & Curves (10)