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1y19

Structural basis for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

Mus musculus

UniProt O70161

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Talin 1 × 1 （P26039） water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Talin 1 × 1 （P26039） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Talin 1 × 1 （P26039） water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Talin 1 × 1 （P26039） water × 2 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 Talin 1 × 1 （P26039） water × 2 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 Talin 1 × 1 （P26039） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1y19 1y19 1y19 1y19 1y19 1y19 2h7d 2h7e

8 assemblies

View Construct and Data Evidence
UniProt name PI51C_MOUSE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–14； UniProt 638–651 Author chain C； PDBConstruct 1–14； UniProt 638–651 Author chain E； PDBConstruct 1–14； UniProt 638–651 Author chain G； PDBConstruct 1–14； UniProt 638–651 Author chain I； PDBConstruct 1–14； UniProt 638–651 Author chain K； PDBConstruct 1–14； UniProt 638–651

Talin 1

Mus musculus

UniProt P26039

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma × 1 （O70161） water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma × 1 （O70161） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma × 1 （O70161） water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma × 1 （O70161） water × 2 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 Phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma × 1 （O70161） water × 2 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 Phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma × 1 （O70161） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1sj7 1sj7 1sj7 1sj8 1u89 2b0h 2jsw 2kbb 2kc2 2kvp 2l10 2l7a

24 assemblies; showing the first 12

Homodimer
1sj7 1sj7 2qdq 4f7g

4 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1t01 1y19 1y19 1y19 1y19 1y19 1y19 1zw3 2g35 2kgx 3s90 3s90

43 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TLN1_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–202； UniProt 209–410 Author chain D； PDBConstruct 1–202； UniProt 209–410 Author chain F； PDBConstruct 1–202； UniProt 209–410 Author chain H； PDBConstruct 1–202； UniProt 209–410 Author chain J； PDBConstruct 1–202； UniProt 209–410 Author chain L； PDBConstruct 1–202； UniProt 209–410

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1y19
Deposition date deposition_date2004-11-17
Structure title titleStructural basis for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions
Keywords keywordsFOCAL ADHESION; FERM DOMAIN; CYTOSKELETON; NPXY MOTIF; PTB DOMAIN, STRUCTURAL PROTEIN, SIGNALING PROTEIN; STRUCTURAL PROTEIN, SIGNALING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1y19__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1y19__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1y19__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）21.45 Å
Rg (electron density)20.62 Å
Total Rg21.41 Å
Atom count1647
Residues203
Excluded volume29589 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1y19__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1y19__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 1y19__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 1y19__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 1y19__assembly_5__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 1y19__assembly_6__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 24 domains

SCOP 2.08 (12 domains)

Domain ID domain_idd1y19b1
Class classa — All alpha proteins
Fold Fold folda.11 — Acyl-CoA binding protein-like
Superfamily Superfamily superfamilya.11.2 — Second domain of FERM
Family Family familya.11.2.1 — Second domain of FERM
Domain ID domain_idd1y19b2
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.5 — Third domain of FERM
Domain ID domain_idd1y19d1
Class classa — All alpha proteins
Fold Fold folda.11 — Acyl-CoA binding protein-like
Superfamily Superfamily superfamilya.11.2 — Second domain of FERM
Family Family familya.11.2.1 — Second domain of FERM
Domain ID domain_idd1y19d2
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.5 — Third domain of FERM
Domain ID domain_idd1y19f1
Class classa — All alpha proteins
Fold Fold folda.11 — Acyl-CoA binding protein-like
Superfamily Superfamily superfamilya.11.2 — Second domain of FERM
Family Family familya.11.2.1 — Second domain of FERM
Domain ID domain_idd1y19f2
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.5 — Third domain of FERM
Domain ID domain_idd1y19h1
Class classa — All alpha proteins
Fold Fold folda.11 — Acyl-CoA binding protein-like
Superfamily Superfamily superfamilya.11.2 — Second domain of FERM
Family Family familya.11.2.1 — Second domain of FERM
Domain ID domain_idd1y19h2
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.5 — Third domain of FERM
Domain ID domain_idd1y19j1
Class classa — All alpha proteins
Fold Fold folda.11 — Acyl-CoA binding protein-like
Superfamily Superfamily superfamilya.11.2 — Second domain of FERM
Family Family familya.11.2.1 — Second domain of FERM
Domain ID domain_idd1y19j2
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.5 — Third domain of FERM
Domain ID domain_idd1y19l1
Class classa — All alpha proteins
Fold Fold folda.11 — Acyl-CoA binding protein-like
Superfamily Superfamily superfamilya.11.2 — Second domain of FERM
Family Family familya.11.2.1 — Second domain of FERM
Domain ID domain_idd1y19l2
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.5 — Third domain of FERM

CATH v4.4 (12 domains)

Domain ID domain_id1y19B01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology80 — Acyl-CoA Binding Protein
Homologous superfamily homologous superfamily10 —
Domain ID domain_id1y19B02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Domain ID domain_id1y19D01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology80 — Acyl-CoA Binding Protein
Homologous superfamily homologous superfamily10 —
Domain ID domain_id1y19D02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Domain ID domain_id1y19F01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology80 — Acyl-CoA Binding Protein
Homologous superfamily homologous superfamily10 —
Domain ID domain_id1y19F02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Domain ID domain_id1y19H01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology80 — Acyl-CoA Binding Protein
Homologous superfamily homologous superfamily10 —
Domain ID domain_id1y19H02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Domain ID domain_id1y19J01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology80 — Acyl-CoA Binding Protein
Homologous superfamily homologous superfamily10 —
Domain ID domain_id1y19J02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Domain ID domain_id1y19L01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology80 — Acyl-CoA Binding Protein
Homologous superfamily homologous superfamily10 —
Domain ID domain_id1y19L02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
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7. Citations (1)