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4c2b

Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation in Complex with High Affinity GPIb alpha

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

VON WILLEBRAND FACTOR

HOMO SAPIENS

UniProt P04275

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 PLATELET GLYCOPROTEIN IB ALPHA CHAIN × 1 （P07359） SULFATE ION × 2 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 PLATELET GLYCOPROTEIN IB ALPHA CHAIN × 1 （P07359） SULFATE ION × 2 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 PLATELET GLYCOPROTEIN IB ALPHA CHAIN × 1 （P07359） SULFATE ION × 2 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 PLATELET GLYCOPROTEIN IB ALPHA CHAIN × 1 （P07359） SULFATE ION × 4 DI(HYDROXYETHYL)ETHER × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ao3 1ao3 1atz 1atz 1auq 1ijb 2mhp 2mhq 3ppv 3ppw 3ppx 3ppy

22 assemblies; showing the first 12

Homodimer
4nt5

1 assemblies

Homotetramer
7wn4 7wpp

2 assemblies

Other homooligomers
7wn3 7wn6 7wpq 7wpr 7wps 7wqt 8d3c 8d3d

8 assemblies

Heteromeric or nucleic-acid complex
1fe8 1fe8 1fe8 1fe8 1fns 1ijk 1m10 1oak 1sq0 1u0n 1uex 2adf

32 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name VWF_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–209； UniProt 1264–1471 Author chain C； PDBConstruct 2–209； UniProt 1264–1471 Author chain E； PDBConstruct 2–209； UniProt 1264–1471 Author chain G； PDBConstruct 2–209； UniProt 1264–1471

PLATELET GLYCOPROTEIN IB ALPHA CHAIN

HOMO SAPIENS

UniProt P07359

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 VON WILLEBRAND FACTOR × 1 （P04275） SULFATE ION × 2 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 VON WILLEBRAND FACTOR × 1 （P04275） SULFATE ION × 2 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 VON WILLEBRAND FACTOR × 1 （P04275） SULFATE ION × 2 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 VON WILLEBRAND FACTOR × 1 （P04275） SULFATE ION × 4 DI(HYDROXYETHYL)ETHER × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1gwb 1gwb 1m0z 1m0z 1qyy

5 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1m10 1ook 1p8v 1p9a 1qyy 1sq0 1u0n 2bp3 2bp3 3p72 3pmh 4c2a

28 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GP1BA_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–290； UniProt 17–306 Author chain D； PDBConstruct 1–290； UniProt 17–306 Author chain F； PDBConstruct 1–290； UniProt 17–306 Author chain H； PDBConstruct 1–290； UniProt 17–306

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4c2b
Deposition date deposition_date2013-08-16
Structure title titleCrystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation in Complex with High Affinity GPIb alpha
Keywords keywordsBLOOD CLOTTING; BLOOD CLOTTING
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4c2b__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4c2b__assembly_3__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4c2b__assembly_3__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）24.52 Å
Rg (electron density)23.35 Å
Total Rg24.32 Å
Atom count3682
Residues463
Excluded volume66354 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4c2b__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4c2b__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 4c2b__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 4c2b__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 16 domains

SCOP 2.08 (8 domains)

Domain ID domain_idd4c2ba_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.62 — vWA-like
Superfamily Superfamily superfamilyc.62.1 — vWA-like
Family Family familyc.62.1.1 — Integrin A (or I) domain
Domain ID domain_idd4c2bb_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily Superfamily superfamilyc.10.2 — L domain-like
Family Family familyc.10.2.7 — Ngr ectodomain-like
Domain ID domain_idd4c2bc_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.62 — vWA-like
Superfamily Superfamily superfamilyc.62.1 — vWA-like
Family Family familyc.62.1.1 — Integrin A (or I) domain
Domain ID domain_idd4c2bd_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily Superfamily superfamilyc.10.2 — L domain-like
Family Family familyc.10.2.7 — Ngr ectodomain-like
Domain ID domain_idd4c2be_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.62 — vWA-like
Superfamily Superfamily superfamilyc.62.1 — vWA-like
Family Family familyc.62.1.1 — Integrin A (or I) domain
Domain ID domain_idd4c2bf_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily Superfamily superfamilyc.10.2 — L domain-like
Family Family familyc.10.2.7 — Ngr ectodomain-like
Domain ID domain_idd4c2bg_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.62 — vWA-like
Superfamily Superfamily superfamilyc.62.1 — vWA-like
Family Family familyc.62.1.1 — Integrin A (or I) domain
Domain ID domain_idd4c2bh_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily Superfamily superfamilyc.10.2 — L domain-like
Family Family familyc.10.2.7 — Ngr ectodomain-like

CATH v4.4 (8 domains)

Domain ID domain_id4c2bA00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily410 — von Willebrand factor, type A domain
Domain ID domain_id4c2bB00
Class class3 — Alpha Beta
Architecture architecture80 — Alpha-Beta Horseshoe
Topology topology10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Homologous superfamily homologous superfamily10 — Ribonuclease Inhibitor
Domain ID domain_id4c2bC00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily410 — von Willebrand factor, type A domain
Domain ID domain_id4c2bD00
Class class3 — Alpha Beta
Architecture architecture80 — Alpha-Beta Horseshoe
Topology topology10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Homologous superfamily homologous superfamily10 — Ribonuclease Inhibitor
Domain ID domain_id4c2bE00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily410 — von Willebrand factor, type A domain
Domain ID domain_id4c2bF00
Class class3 — Alpha Beta
Architecture architecture80 — Alpha-Beta Horseshoe
Topology topology10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Homologous superfamily homologous superfamily10 — Ribonuclease Inhibitor
Domain ID domain_id4c2bG00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily410 — von Willebrand factor, type A domain
Domain ID domain_id4c2bH00
Class class3 — Alpha Beta
Architecture architecture80 — Alpha-Beta Horseshoe
Topology topology10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Homologous superfamily homologous superfamily10 — Ribonuclease Inhibitor
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7. Citations (1)