4c2m

Structure of RNA polymerase I at 2.8 A resolution

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 11	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 10	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB4_YEAST
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain 1； PDBConstruct 1–70； UniProt 1–70 Author chain L； PDBConstruct 1–70； UniProt 1–70

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49

OrganismNot specified

UniProt Q01080

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 11	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 10	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPA49_YEAST
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain 2； PDBConstruct 1–415； UniProt 1–415 Author chain M； PDBConstruct 1–415； UniProt 1–415

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34

OrganismNot specified

UniProt P47006

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 11	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 10	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPA34_YEAST
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain 3； PDBConstruct 1–233； UniProt 1–233 Author chain N； PDBConstruct 1–233； UniProt 1–233

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43

OrganismNot specified

UniProt P46669

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 11	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 10	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPA43_YEAST
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain 4； PDBConstruct 1–326； UniProt 1–326 Author chain G； PDBConstruct 1–326； UniProt 1–326 Author chain O； PDBConstruct 1–326； UniProt 1–326 Author chain V； PDBConstruct 1–326； UniProt 1–326

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190

OrganismNot specified

UniProt P10964

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 11	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 10	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPA1_YEAST
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain A； PDBConstruct 1–1664； UniProt 1–1664 Author chain P； PDBConstruct 1–1664； UniProt 1–1664

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135

OrganismNot specified

UniProt P22138

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 11	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 10	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPA2_YEAST
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain B； PDBConstruct 1–1203； UniProt 1–1203 Author chain Q； PDBConstruct 1–1203； UniProt 1–1203

DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1

OrganismNot specified

UniProt P07703

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 11	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 10	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAC1_YEAST
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain C； PDBConstruct 1–335； UniProt 1–335 Author chain R； PDBConstruct 1–335； UniProt 1–335

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14

OrganismNot specified

UniProt P50106

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 11	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 10	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPA14_YEAST
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain D； PDBConstruct 1–137； UniProt 1–137 Author chain S； PDBConstruct 1–137； UniProt 1–137

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1

OrganismNot specified

UniProt P20434

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 11	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 10	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB1_YEAST
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain E； PDBConstruct 1–215； UniProt 1–215 Author chain T； PDBConstruct 1–215； UniProt 1–215

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2

OrganismNot specified

UniProt P20435

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 11	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 10	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB2_YEAST
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain F； PDBConstruct 1–155； UniProt 1–155 Author chain U； PDBConstruct 1–155； UniProt 1–155

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3

OrganismNot specified

UniProt P20436

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 11	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 10	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB3_YEAST
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain H； PDBConstruct 1–146； UniProt 1–146 Author chain W； PDBConstruct 1–146； UniProt 1–146

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12

OrganismNot specified

UniProt P32529

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 11	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 10	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPA12_YEAST
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain I； PDBConstruct 1–125； UniProt 1–125 Author chain X； PDBConstruct 1–125； UniProt 1–125

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5

OrganismNot specified

UniProt P22139

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 11	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） ZINC ION × 7 SULFATE ION × 1 water × 10	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB5_YEAST
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain J； PDBConstruct 1–70； UniProt 1–70 Author chain Y； PDBConstruct 1–70； UniProt 1–70

DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2

OrganismNot specified

UniProt P28000

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） ZINC ION × 7 SULFATE ION × 1 water × 11	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 15	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 2 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） ZINC ION × 7 SULFATE ION × 1 water × 10	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAC2_YEAST
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain K； PDBConstruct 1–142； UniProt 1–142 Author chain Z； PDBConstruct 1–142； UniProt 1–142

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	4c2m
Deposition date deposition_date	2013-08-19
Structure title title	Structure of RNA polymerase I at 2.8 A resolution
Keywords keywords	TRANSCRIPTION, RIBOSOME BIOGENESIS; TRANSCRIPTION
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4c2m__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4c2m__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

4c2m__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	52.54 Å
Rg (electron density)	52.22 Å
Total Rg	52.40 Å
Atom count	34512
Residues	4345
Excluded volume	615170 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`4c2m__assembly_1__model_1`	pentadecameric （15）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`4c2m__assembly_2__model_1`	pentadecameric （15）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (17)

Entity 1 Entity 1 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4
Molecular weight formula_weight	7730.0 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	1,L
Atom count atom_count	69107

MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR

Entity 2 Entity 2 polymer

Description description	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49
Molecular weight formula_weight	46721.7 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	2,M

MSVKRSVSEIEIESVQDQPSVAVGSFFKGFRAPSDTTFDLYKKKKSEKDEFVLHGENERLEYEGYTDSSSQASNQYVVGLFNPEKKSIQLYKAPVLVSKVVSKSSKNLRGPKIKSKSDTRPSALRNALGEAFGTKKAKKAIADLERNRIDSDKLTDSAIDIVDSVRTASKDLPTRAQLDEITSNDRPTPLANIDATDVEQIYPIESIIPKKELQFIRVSSILKEADKEKKLELFPYQNNSKYVAKKLDSLTQPSQMTKLQLLYYLSLLLGVYENRRVNNKTKLLERLNSPPEILVDGILSRFTVIKPGQFGRSKDRSYFIDPQNEDKILCYILAIIMHLDNFIVEITPLAHELNLKPSKVVSLFRVLGAIVKGATVAQAEAFGIPKSTAASYKIATMKVPFKLPEMTRRGRGPRR

Entity 3 Entity 3 polymer

Description description	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34
Molecular weight formula_weight	26933.5 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	3,N

MSKLSKDYVSDSDSDDEVISNEFSIPDGFKKCKHLKNFPLNGDNKKKAKQQQVWLIKFPSNVDISKLKSLPVDFESSTTMTIDKHDYKIMDDTDIESSLTQDNLSNMTLLVPSESKESLKIASTAKDNAPLQFDKVFSVSETAKIPAIDYSKVRVPRKDVPKVEGLKLEHFATGYDAEDFHVAEEVKENKKEPKKRSHHDDEEESSEKKKKKKEKREKREKKDKKDKKKKHRD

Entity 4 Entity 4 polymer

Description description	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43
Molecular weight formula_weight	36264.9 kDa
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	4,G,O,V

MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQGVMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHVNLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVINTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTGRVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEVKEDNGSEIVYEENTSESNDGESSDSD

Entity 5 Entity 5 polymer

Description description	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190
Molecular weight formula_weight	186677.0 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,P

MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRNLCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYACKLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNELKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFSPKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDVGRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVLVVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIFSRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAARSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNEDGSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASMMGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTPTSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIFKPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGILDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGNKWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKVNAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVMVSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKYNPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENFQDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQMTLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISKVLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQFIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQAVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMNKVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQIPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARNTIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQFLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Entity 6 Entity 6 polymer

Description description	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135
Molecular weight formula_weight	135910.3 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,Q

MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGLLNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERKVYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYELVQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVRPDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDSFLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLVHLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEYLQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQVSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCGLLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQGKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDKEDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQMGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTGYDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKLDEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQTVSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTIGMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGEELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALIGHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKKLLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNVEPK

Entity 7 Entity 7 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1
Molecular weight formula_weight	37732.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C,R

MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINIDTSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNLPDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFADCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIKGESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIFNVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Entity 8 Entity 8 polymer

Description description	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14
Molecular weight formula_weight	14599.1 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D,S

MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTISGNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKETSIGVSATGGKKTTFADE

Entity 9 Entity 9 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1
Molecular weight formula_weight	25117.1 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E,T

MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Entity 10 Entity 10 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2
Molecular weight formula_weight	17931.8 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F,U

MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQHEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Entity 11 Entity 11 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3
Molecular weight formula_weight	16525.4 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H,W

MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIASSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGGLLMRLEGNYRNLNNLKQENAYLLIRR

Entity 12 Entity 12 polymer

Description description	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12
Molecular weight formula_weight	13676.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I,X

MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSLRAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYKFRTNN

Entity 13 Entity 13 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5
Molecular weight formula_weight	8290.7 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J,Y

MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKFLRYNPLEKRD

Entity 14 Entity 14 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2
Molecular weight formula_weight	16167.9 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K,Z

MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTSASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKGLKDLMDLCDVVESKFTEKIKSM

Entity 15 Entity 15 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	14

Entity 16 Entity 16 non-polymer

Description description	SULFATE ION
Molecular weight formula_weight	96.1 kDa
Source method src_method	syn
Copy count entity_count	2

Entity 17 Entity 17 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	262

▼

6. Fold Classification (SCOP + CATH) 78 domains

SCOP 2.08 (32 domains)

Domain ID domain_id	d4c2m1_
Class class	g — Small proteins
Fold Fold fold	g.41 — Rubredoxin-like
Superfamily Superfamily superfamily	g.41.9 — RNA polymerase subunits
Family Family family	g.41.9.2 — RBP12 subunit of RNA polymerase II

Domain ID domain_id	d4c2m2_
Class class	b — All beta proteins
Fold Fold fold	b.65 — triple barrel
Superfamily Superfamily superfamily	b.65.1 — Rap30/74 interaction domain-like
Family Family family	b.65.1.2 — RNA polymerase I A49/34.5, interaction domains

Domain ID domain_id	d4c2m3_
Class class	b — All beta proteins
Fold Fold fold	b.65 — triple barrel
Superfamily Superfamily superfamily	b.65.1 — Rap30/74 interaction domain-like
Family Family family	b.65.1.2 — RNA polymerase I A49/34.5, interaction domains

Domain ID domain_id	d4c2ma_
Class class	e — Multi-domain proteins (alpha and beta)
Fold Fold fold	e.29 — beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily Superfamily superfamily	e.29.1 — beta and beta-prime subunits of DNA dependent RNA-polymerase
Family Family family	e.29.1.2 — RNA-polymerase beta-prime

Domain ID domain_id	d4c2mb_
Class class	e — Multi-domain proteins (alpha and beta)
Fold Fold fold	e.29 — beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily Superfamily superfamily	e.29.1 — beta and beta-prime subunits of DNA dependent RNA-polymerase
Family Family family	e.29.1.1 — RNA-polymerase beta

Domain ID domain_id	d4c2mc1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.74 — DCoH-like
Superfamily Superfamily superfamily	d.74.3 — RBP11-like subunits of RNA polymerase
Family Family family	d.74.3.1 — RNA polymerase alpha subunit dimerisation domain

Domain ID domain_id	d4c2mc2
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.181 — Insert subdomain of RNA polymerase alpha subunit
Superfamily Superfamily superfamily	d.181.1 — Insert subdomain of RNA polymerase alpha subunit
Family Family family	d.181.1.1 — Insert subdomain of RNA polymerase alpha subunit

Domain ID domain_id	d4c2me1
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.52 — Restriction endonuclease-like
Superfamily Superfamily superfamily	c.52.3 — Eukaryotic RPB5 N-terminal domain
Family Family family	c.52.3.1 — Eukaryotic RPB5 N-terminal domain

Domain ID domain_id	d4c2me2
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.78 — RPB5-like RNA polymerase subunit
Superfamily Superfamily superfamily	d.78.1 — RPB5-like RNA polymerase subunit
Family Family family	d.78.1.1 — RPB5

Domain ID domain_id	d4c2mf_
Class class	a — All alpha proteins
Fold Fold fold	a.143 — RPB6/omega subunit-like
Superfamily Superfamily superfamily	a.143.1 — RPB6/omega subunit-like
Family Family family	a.143.1.2 — RPB6

Domain ID domain_id	d4c2mg1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.230 — Dodecin subunit-like
Superfamily Superfamily superfamily	d.230.1 — N-terminal, heterodimerisation domain of RBP7 (RpoE)
Family Family family	d.230.1.2 — RNA polymerase I subunit A43, N-terminal domain

Domain ID domain_id	d4c2mh_
Class class	b — All beta proteins
Fold Fold fold	b.40 — OB-fold
Superfamily Superfamily superfamily	b.40.4 — Nucleic acid-binding proteins
Family Family family	b.40.4.8 — RNA polymerase subunit RBP8

Domain ID domain_id	d4c2mi1
Class class	g — Small proteins
Fold Fold fold	g.41 — Rubredoxin-like
Superfamily Superfamily superfamily	g.41.3 — Zinc beta-ribbon
Family Family family	g.41.3.1 — Transcriptional factor domain

Domain ID domain_id	d4c2mi2
Class class	g — Small proteins
Fold Fold fold	g.41 — Rubredoxin-like
Superfamily Superfamily superfamily	g.41.3 — Zinc beta-ribbon
Family Family family	g.41.3.1 — Transcriptional factor domain

Domain ID domain_id	d4c2mj_
Class class	a — All alpha proteins
Fold Fold fold	a.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamily	a.4.11 — RNA polymerase subunit RPB10
Family Family family	a.4.11.1 — RNA polymerase subunit RPB10

Domain ID domain_id	d4c2mk_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.74 — DCoH-like
Superfamily Superfamily superfamily	d.74.3 — RBP11-like subunits of RNA polymerase
Family Family family	d.74.3.0 — automated matches

Domain ID domain_id	d4c2ml_
Class class	g — Small proteins
Fold Fold fold	g.41 — Rubredoxin-like
Superfamily Superfamily superfamily	g.41.9 — RNA polymerase subunits
Family Family family	g.41.9.2 — RBP12 subunit of RNA polymerase II

Domain ID domain_id	d4c2mm_
Class class	b — All beta proteins
Fold Fold fold	b.65 — triple barrel
Superfamily Superfamily superfamily	b.65.1 — Rap30/74 interaction domain-like
Family Family family	b.65.1.2 — RNA polymerase I A49/34.5, interaction domains

Domain ID domain_id	d4c2mn_
Class class	b — All beta proteins
Fold Fold fold	b.65 — triple barrel
Superfamily Superfamily superfamily	b.65.1 — Rap30/74 interaction domain-like
Family Family family	b.65.1.2 — RNA polymerase I A49/34.5, interaction domains

Domain ID domain_id	d4c2mp_
Class class	e — Multi-domain proteins (alpha and beta)
Fold Fold fold	e.29 — beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily Superfamily superfamily	e.29.1 — beta and beta-prime subunits of DNA dependent RNA-polymerase
Family Family family	e.29.1.2 — RNA-polymerase beta-prime

Domain ID domain_id	d4c2mq_
Class class	e — Multi-domain proteins (alpha and beta)
Fold Fold fold	e.29 — beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily Superfamily superfamily	e.29.1 — beta and beta-prime subunits of DNA dependent RNA-polymerase
Family Family family	e.29.1.1 — RNA-polymerase beta

Domain ID domain_id	d4c2mr1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.74 — DCoH-like
Superfamily Superfamily superfamily	d.74.3 — RBP11-like subunits of RNA polymerase
Family Family family	d.74.3.1 — RNA polymerase alpha subunit dimerisation domain

Domain ID domain_id	d4c2mr2
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.181 — Insert subdomain of RNA polymerase alpha subunit
Superfamily Superfamily superfamily	d.181.1 — Insert subdomain of RNA polymerase alpha subunit
Family Family family	d.181.1.1 — Insert subdomain of RNA polymerase alpha subunit

Domain ID domain_id	d4c2mt1
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.52 — Restriction endonuclease-like
Superfamily Superfamily superfamily	c.52.3 — Eukaryotic RPB5 N-terminal domain
Family Family family	c.52.3.1 — Eukaryotic RPB5 N-terminal domain

Domain ID domain_id	d4c2mt2
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.78 — RPB5-like RNA polymerase subunit
Superfamily Superfamily superfamily	d.78.1 — RPB5-like RNA polymerase subunit
Family Family family	d.78.1.1 — RPB5

Domain ID domain_id	d4c2mu_
Class class	a — All alpha proteins
Fold Fold fold	a.143 — RPB6/omega subunit-like
Superfamily Superfamily superfamily	a.143.1 — RPB6/omega subunit-like
Family Family family	a.143.1.2 — RPB6

Domain ID domain_id	d4c2mv1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.230 — Dodecin subunit-like
Superfamily Superfamily superfamily	d.230.1 — N-terminal, heterodimerisation domain of RBP7 (RpoE)
Family Family family	d.230.1.2 — RNA polymerase I subunit A43, N-terminal domain

Domain ID domain_id	d4c2mw_
Class class	b — All beta proteins
Fold Fold fold	b.40 — OB-fold
Superfamily Superfamily superfamily	b.40.4 — Nucleic acid-binding proteins
Family Family family	b.40.4.8 — RNA polymerase subunit RBP8

Domain ID domain_id	d4c2mx1
Class class	g — Small proteins
Fold Fold fold	g.41 — Rubredoxin-like
Superfamily Superfamily superfamily	g.41.3 — Zinc beta-ribbon
Family Family family	g.41.3.1 — Transcriptional factor domain

Domain ID domain_id	d4c2mx2
Class class	g — Small proteins
Fold Fold fold	g.41 — Rubredoxin-like
Superfamily Superfamily superfamily	g.41.3 — Zinc beta-ribbon
Family Family family	g.41.3.1 — Transcriptional factor domain

Domain ID domain_id	d4c2my_
Class class	a — All alpha proteins
Fold Fold fold	a.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamily	a.4.11 — RNA polymerase subunit RPB10
Family Family family	a.4.11.1 — RNA polymerase subunit RPB10

Domain ID domain_id	d4c2mz_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.74 — DCoH-like
Superfamily Superfamily superfamily	d.74.3 — RBP11-like subunits of RNA polymerase
Family Family family	d.74.3.0 — automated matches

CATH v4.4 (46 domains)

Domain ID domain_id	4c2m100
Class class	2 — Mainly Beta
Architecture architecture	20 — Single Sheet
Topology topology	28 — Rubrerythrin, domain 2
Homologous superfamily homologous superfamily	30 — RNA polymerase ii, chain L

Domain ID domain_id	4c2m400
Class class	6 — Special
Architecture architecture	10 — Helix non-globular
Topology topology	140 — Helix Hairpins
Homologous superfamily homologous superfamily	1770 —

Domain ID domain_id	4c2mA03
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	40 — Barwin-like endoglucanases
Homologous superfamily homologous superfamily	20 —

Domain ID domain_id	4c2mA04
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1490 — Dna Ligase; domain 1
Homologous superfamily homologous superfamily	180 — RNA polymerase ii

Domain ID domain_id	4c2mA05
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	274 — Enzyme I; Chain A, domain 2
Homologous superfamily homologous superfamily	100 — RNA polymerase Rpb1, domain 3

Domain ID domain_id	4c2mA06
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	132 — Topoisomerase I; Chain A, domain 4
Homologous superfamily homologous superfamily	30 — RNA polymerase Rpb1 funnel domain

Domain ID domain_id	4c2mA08
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	357 — Tetracycline Repressor; domain 2
Homologous superfamily homologous superfamily	120 —

Domain ID domain_id	4c2mA09
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	2850 —

Domain ID domain_id	4c2mB04
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	1110 — Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3
Homologous superfamily homologous superfamily	10 — RNA polymerase Rpb2, domain 2

Domain ID domain_id	4c2mB05
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	1070 — Hypothetical Protein Ta0175; Chain: A, domain 2
Homologous superfamily homologous superfamily	20 —

Domain ID domain_id	4c2mB06
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	270 — Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6
Homologous superfamily homologous superfamily	10 — DNA-directed RNA polymerase, subunit 2, domain 6

Domain ID domain_id	4c2mB07
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	150 — RNA polymerase II, Rpb2 subunit, wall domain

Domain ID domain_id	4c2mB08
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	1800 — DCoH-like
Homologous superfamily homologous superfamily	10 — RNA polymerase alpha subunit dimerisation domain

Domain ID domain_id	4c2mC01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1360 — Gyrase A; domain 2
Homologous superfamily homologous superfamily	10 — RNA polymerase, RBP11-like subunit

Domain ID domain_id	4c2mC02
Class class	2 — Mainly Beta
Architecture architecture	170 — Beta Complex
Topology topology	120 — RNA Polymerase Alpha Subunit; Chain A, domain 2
Homologous superfamily homologous superfamily	12 — DNA-directed RNA polymerase, insert domain

Domain ID domain_id	4c2mD01
Class class	6 — Special
Architecture architecture	10 — Helix non-globular
Topology topology	250 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily	3390 —

Domain ID domain_id	4c2mE01
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	1340 — Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1
Homologous superfamily homologous superfamily	10 — RNA polymerase, Rpb5, N-terminal domain

Domain ID domain_id	4c2mE02
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	940 — Eukaryotic RPB6 RNA polymerase subunit
Homologous superfamily homologous superfamily	20 — RPB5-like RNA polymerase subunit

Domain ID domain_id	4c2mF00
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	940 — Eukaryotic RPB6 RNA polymerase subunit
Homologous superfamily homologous superfamily	10 — RNA polymerase subunit, RPB6/omega

Domain ID domain_id	4c2mG02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	140 — Nucleic acid-binding proteins

Domain ID domain_id	4c2mH00
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	140 — Nucleic acid-binding proteins

Domain ID domain_id	4c2mJ00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily	60 — Homeodomain-like

Domain ID domain_id	4c2mK00
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1360 — Gyrase A; domain 2
Homologous superfamily homologous superfamily	10 — RNA polymerase, RBP11-like subunit

Domain ID domain_id	4c2mL00
Class class	2 — Mainly Beta
Architecture architecture	20 — Single Sheet
Topology topology	28 — Rubrerythrin, domain 2
Homologous superfamily homologous superfamily	30 — RNA polymerase ii, chain L

Domain ID domain_id	4c2mO00
Class class	6 — Special
Architecture architecture	10 — Helix non-globular
Topology topology	140 — Helix Hairpins
Homologous superfamily homologous superfamily	1770 —

Domain ID domain_id	4c2mP03
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	40 — Barwin-like endoglucanases
Homologous superfamily homologous superfamily	20 —

Domain ID domain_id	4c2mP04
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1490 — Dna Ligase; domain 1
Homologous superfamily homologous superfamily	180 — RNA polymerase ii

Domain ID domain_id	4c2mP05
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	274 — Enzyme I; Chain A, domain 2
Homologous superfamily homologous superfamily	100 — RNA polymerase Rpb1, domain 3

Domain ID domain_id	4c2mP06
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	132 — Topoisomerase I; Chain A, domain 4
Homologous superfamily homologous superfamily	30 — RNA polymerase Rpb1 funnel domain

Domain ID domain_id	4c2mP08
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	357 — Tetracycline Repressor; domain 2
Homologous superfamily homologous superfamily	120 —

Domain ID domain_id	4c2mP09
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	2850 —

Domain ID domain_id	4c2mQ04
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	1110 — Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3
Homologous superfamily homologous superfamily	10 — RNA polymerase Rpb2, domain 2

Domain ID domain_id	4c2mQ05
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	1070 — Hypothetical Protein Ta0175; Chain: A, domain 2
Homologous superfamily homologous superfamily	20 —

Domain ID domain_id	4c2mQ06
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	270 — Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6
Homologous superfamily homologous superfamily	10 — DNA-directed RNA polymerase, subunit 2, domain 6

Domain ID domain_id	4c2mQ07
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	150 — RNA polymerase II, Rpb2 subunit, wall domain

Domain ID domain_id	4c2mQ08
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	1800 — DCoH-like
Homologous superfamily homologous superfamily	10 — RNA polymerase alpha subunit dimerisation domain

Domain ID domain_id	4c2mR01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1360 — Gyrase A; domain 2
Homologous superfamily homologous superfamily	10 — RNA polymerase, RBP11-like subunit

Domain ID domain_id	4c2mR02
Class class	2 — Mainly Beta
Architecture architecture	170 — Beta Complex
Topology topology	120 — RNA Polymerase Alpha Subunit; Chain A, domain 2
Homologous superfamily homologous superfamily	12 — DNA-directed RNA polymerase, insert domain

Domain ID domain_id	4c2mS01
Class class	6 — Special
Architecture architecture	10 — Helix non-globular
Topology topology	250 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily	3390 —

Domain ID domain_id	4c2mT01
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	1340 — Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1
Homologous superfamily homologous superfamily	10 — RNA polymerase, Rpb5, N-terminal domain

Domain ID domain_id	4c2mT02
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	940 — Eukaryotic RPB6 RNA polymerase subunit
Homologous superfamily homologous superfamily	20 — RPB5-like RNA polymerase subunit

Domain ID domain_id	4c2mU00
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	940 — Eukaryotic RPB6 RNA polymerase subunit
Homologous superfamily homologous superfamily	10 — RNA polymerase subunit, RPB6/omega

Domain ID domain_id	4c2mV02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	140 — Nucleic acid-binding proteins

Domain ID domain_id	4c2mW00
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	140 — Nucleic acid-binding proteins

Domain ID domain_id	4c2mY00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily	60 — Homeodomain-like

Domain ID domain_id	4c2mZ00
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1360 — Gyrase A; domain 2
Homologous superfamily homologous superfamily	10 — RNA polymerase, RBP11-like subunit

▶

Unit-cell length a length_a	122.740 Å
Unit-cell length b length_b	139.020 Å
Unit-cell length c length_c	209.550 Å
Unit-cell angle α angle_alpha	108.06 °
Unit-cell angle β angle_beta	95.40 °
Unit-cell angle γ angle_gamma	93.85 °
Molecules per unit cell Z z_pdb	4

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	2.800 Å
Low-resolution limit resolution_low	39.292 Å
R factor r_factor	0.1697
R_work r_work	0.1689
R_free r_free	0.2099

Structure of RNA polymerase I at 2.8 A resolution

1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer