4c3i

Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 1 （P46669） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） SULFATE ION × 3 ZINC ION × 7 MAGNESIUM ION × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPA1_YEAST
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–1664； UniProt 1–1664

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135

OrganismNot specified

UniProt P22138

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 1 （P46669） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） SULFATE ION × 3 ZINC ION × 7 MAGNESIUM ION × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPA2_YEAST
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–1203； UniProt 1–1203

DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1

OrganismNot specified

UniProt P07703

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 1 （P46669） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） SULFATE ION × 3 ZINC ION × 7 MAGNESIUM ION × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAC1_YEAST
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–335； UniProt 1–335

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14

OrganismNot specified

UniProt P50106

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 1 （P46669） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） SULFATE ION × 3 ZINC ION × 7 MAGNESIUM ION × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPA14_YEAST
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–137； UniProt 1–137

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1

OrganismNot specified

UniProt P20434

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 1 （P46669） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） SULFATE ION × 3 ZINC ION × 7 MAGNESIUM ION × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB1_YEAST
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–215； UniProt 1–215

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2

OrganismNot specified

UniProt P20435

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 1 （P46669） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） SULFATE ION × 3 ZINC ION × 7 MAGNESIUM ION × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB2_YEAST
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–155； UniProt 1–155

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43

OrganismNot specified

UniProt P46669

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） SULFATE ION × 3 ZINC ION × 7 MAGNESIUM ION × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPA43_YEAST
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–326； UniProt 1–326

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3

OrganismNot specified

UniProt P20436

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 1 （P46669） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） SULFATE ION × 3 ZINC ION × 7 MAGNESIUM ION × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB3_YEAST
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain H； PDBConstruct 1–146； UniProt 1–146

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12

OrganismNot specified

UniProt P32529

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 1 （P46669） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） SULFATE ION × 3 ZINC ION × 7 MAGNESIUM ION × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPA12_YEAST
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain I； PDBConstruct 1–125； UniProt 1–125

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5

OrganismNot specified

UniProt P22139

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 1 （P46669） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） SULFATE ION × 3 ZINC ION × 7 MAGNESIUM ION × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB5_YEAST
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain J； PDBConstruct 1–70； UniProt 1–70

DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2

OrganismNot specified

UniProt P28000

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 1 （P46669） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） SULFATE ION × 3 ZINC ION × 7 MAGNESIUM ION × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAC2_YEAST
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain K； PDBConstruct 1–142； UniProt 1–142

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4

OrganismNot specified

UniProt P40422

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 1 （P46669） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） SULFATE ION × 3 ZINC ION × 7 MAGNESIUM ION × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB4_YEAST
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain L； PDBConstruct 1–70； UniProt 1–70

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49

OrganismNot specified

UniProt Q01080

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 1 （P46669） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 × 1 （P47006） SULFATE ION × 3 ZINC ION × 7 MAGNESIUM ION × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPA49_YEAST
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain M； PDBConstruct 1–415； UniProt 1–415

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34

OrganismNot specified

UniProt P47006

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 × 1 （P10964） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 × 1 （P22138） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 × 1 （P50106） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 × 1 （P46669） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 × 1 （P32529） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 × 1 （Q01080） SULFATE ION × 3 ZINC ION × 7 MAGNESIUM ION × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPA34_YEAST
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain N； PDBConstruct 1–233； UniProt 1–233

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	4c3i
Deposition date deposition_date	2013-08-24
Structure title title	Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100
Keywords keywords	TRANSFERASE; TRANSFERASE
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4c3i__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4c3i__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

4c3i__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	53.37 Å
Rg (electron density)	52.90 Å
Total Rg	53.08 Å
Atom count	34252
Residues	4316
Excluded volume	610400 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`4c3i__assembly_1__model_1`	tetradecameric （14）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (18)

Entity 1 Entity 1 polymer

Description description	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190
Molecular weight formula_weight	186677.0 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A
Atom count atom_count	34252

MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRNLCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYACKLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNELKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFSPKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDVGRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVLVVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIFSRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAARSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNEDGSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASMMGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTPTSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIFKPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGILDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGNKWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKVNAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVMVSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKYNPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENFQDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQMTLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISKVLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQFIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQAVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMNKVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQIPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARNTIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQFLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Entity 2 Entity 2 polymer

Description description	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135
Molecular weight formula_weight	135910.3 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGLLNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERKVYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYELVQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVRPDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDSFLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLVHLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEYLQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQVSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCGLLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQGKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDKEDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQMGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTGYDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKLDEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQTVSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTIGMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGEELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALIGHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKKLLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNVEPK

Entity 3 Entity 3 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1
Molecular weight formula_weight	37732.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINIDTSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNLPDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFADCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIKGESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIFNVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Entity 4 Entity 4 polymer

Description description	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14
Molecular weight formula_weight	14585.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MMKGSRRTGNNSATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTISGNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKETSIGVSATGGKKTTFADE

Entity 5 Entity 5 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1
Molecular weight formula_weight	25117.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Entity 6 Entity 6 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2
Molecular weight formula_weight	17931.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQHEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Entity 7 Entity 7 polymer

Description description	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43
Molecular weight formula_weight	36264.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQGVMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHVNLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVINTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTGRVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEVKEDNGSEIVYEENTSESNDGESSDSD

Entity 8 Entity 8 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3
Molecular weight formula_weight	16525.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIASSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGGLLMRLEGNYRNLNNLKQENAYLLIRR

Entity 9 Entity 9 polymer

Description description	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12
Molecular weight formula_weight	13676.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSLRAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYKFRTNN

Entity 10 Entity 10 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5
Molecular weight formula_weight	8290.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKFLRYNPLEKRD

Entity 11 Entity 11 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2
Molecular weight formula_weight	16167.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTSASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKGLKDLMDLCDVVESKFTEKIKSM

Entity 12 Entity 12 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4
Molecular weight formula_weight	7730.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR

Entity 13 Entity 13 polymer

Description description	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49
Molecular weight formula_weight	46721.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M

MSVKRSVSEIEIESVQDQPSVAVGSFFKGFRAPSDTTFDLYKKKKSEKDEFVLHGENERLEYEGYTDSSSQASNQYVVGLFNPEKKSIQLYKAPVLVSKVVSKSSKNLRGPKIKSKSDTRPSALRNALGEAFGTKKAKKAIADLERNRIDSDKLTDSAIDIVDSVRTASKDLPTRAQLDEITSNDRPTPLANIDATDVEQIYPIESIIPKKELQFIRVSSILKEADKEKKLELFPYQNNSKYVAKKLDSLTQPSQMTKLQLLYYLSLLLGVYENRRVNNKTKLLERLNSPPEILVDGILSRFTVIKPGQFGRSKDRSYFIDPQNEDKILCYILAIIMHLDNFIVEITPLAHELNLKPSKVVSLFRVLGAIVKGATVAQAEAFGIPKSTAASYKIATMKVPFKLPEMTRRGRGPRR

Entity 14 Entity 14 polymer

Description description	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34
Molecular weight formula_weight	26933.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N

MSKLSKDYVSDSDSDDEVISNEFSIPDGFKKCKHLKNFPLNGDNKKKAKQQQVWLIKFPSNVDISKLKSLPVDFESSTTMTIDKHDYKIMDDTDIESSLTQDNLSNMTLLVPSESKESLKIASTAKDNAPLQFDKVFSVSETAKIPAIDYSKVRVPRKDVPKVEGLKLEHFATGYDAEDFHVAEEVKENKKEPKKRSHHDDEEESSEKKKKKKEKREKREKKDKKDKKKKHRD

Entity 15 Entity 15 non-polymer

Description description	SULFATE ION
Molecular weight formula_weight	96.1 kDa
Source method src_method	syn
Copy count entity_count	3

Entity 16 Entity 16 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	7

Entity 17 Entity 17 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 18 Entity 18 non-polymer

Description description	(4S)-2-METHYL-2,4-PENTANEDIOL
Molecular weight formula_weight	118.2 kDa
Source method src_method	syn
Copy count entity_count	1

▼

6. Fold Classification (SCOP + CATH) 35 domains

SCOP 2.08 (14 domains)

Domain ID domain_id	d4c3ia_
Class class	e — Multi-domain proteins (alpha and beta)
Fold Fold fold	e.29 — beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily Superfamily superfamily	e.29.1 — beta and beta-prime subunits of DNA dependent RNA-polymerase
Family Family family	e.29.1.2 — RNA-polymerase beta-prime

Domain ID domain_id	d4c3ib_
Class class	e — Multi-domain proteins (alpha and beta)
Fold Fold fold	e.29 — beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily Superfamily superfamily	e.29.1 — beta and beta-prime subunits of DNA dependent RNA-polymerase
Family Family family	e.29.1.1 — RNA-polymerase beta

Domain ID domain_id	d4c3ie1
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.52 — Restriction endonuclease-like
Superfamily Superfamily superfamily	c.52.3 — Eukaryotic RPB5 N-terminal domain
Family Family family	c.52.3.1 — Eukaryotic RPB5 N-terminal domain

Domain ID domain_id	d4c3ie2
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.78 — RPB5-like RNA polymerase subunit
Superfamily Superfamily superfamily	d.78.1 — RPB5-like RNA polymerase subunit
Family Family family	d.78.1.0 — automated matches

Domain ID domain_id	d4c3if_
Class class	a — All alpha proteins
Fold Fold fold	a.143 — RPB6/omega subunit-like
Superfamily Superfamily superfamily	a.143.1 — RPB6/omega subunit-like
Family Family family	a.143.1.2 — RPB6

Domain ID domain_id	d4c3ig1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.230 — Dodecin subunit-like
Superfamily Superfamily superfamily	d.230.1 — N-terminal, heterodimerisation domain of RBP7 (RpoE)
Family Family family	d.230.1.0 — automated matches

Domain ID domain_id	d4c3ih_
Class class	b — All beta proteins
Fold Fold fold	b.40 — OB-fold
Superfamily Superfamily superfamily	b.40.4 — Nucleic acid-binding proteins
Family Family family	b.40.4.8 — RNA polymerase subunit RBP8

Domain ID domain_id	d4c3ii1
Class class	g — Small proteins
Fold Fold fold	g.41 — Rubredoxin-like
Superfamily Superfamily superfamily	g.41.3 — Zinc beta-ribbon
Family Family family	g.41.3.1 — Transcriptional factor domain

Domain ID domain_id	d4c3ii2
Class class	g — Small proteins
Fold Fold fold	g.41 — Rubredoxin-like
Superfamily Superfamily superfamily	g.41.3 — Zinc beta-ribbon
Family Family family	g.41.3.1 — Transcriptional factor domain

Domain ID domain_id	d4c3ij_
Class class	a — All alpha proteins
Fold Fold fold	a.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamily	a.4.11 — RNA polymerase subunit RPB10
Family Family family	a.4.11.1 — RNA polymerase subunit RPB10

Domain ID domain_id	d4c3ik_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.74 — DCoH-like
Superfamily Superfamily superfamily	d.74.3 — RBP11-like subunits of RNA polymerase
Family Family family	d.74.3.0 — automated matches

Domain ID domain_id	d4c3il_
Class class	g — Small proteins
Fold Fold fold	g.41 — Rubredoxin-like
Superfamily Superfamily superfamily	g.41.9 — RNA polymerase subunits
Family Family family	g.41.9.2 — RBP12 subunit of RNA polymerase II

Domain ID domain_id	d4c3im_
Class class	b — All beta proteins
Fold Fold fold	b.65 — triple barrel
Superfamily Superfamily superfamily	b.65.1 — Rap30/74 interaction domain-like
Family Family family	b.65.1.0 — automated matches

Domain ID domain_id	d4c3in_
Class class	b — All beta proteins
Fold Fold fold	b.65 — triple barrel
Superfamily Superfamily superfamily	b.65.1 — Rap30/74 interaction domain-like
Family Family family	b.65.1.2 — RNA polymerase I A49/34.5, interaction domains

CATH v4.4 (21 domains)

Domain ID domain_id	4c3iA02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	40 — Barwin-like endoglucanases
Homologous superfamily homologous superfamily	20 —

Domain ID domain_id	4c3iA03
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1490 — Dna Ligase; domain 1
Homologous superfamily homologous superfamily	180 — RNA polymerase ii

Domain ID domain_id	4c3iA04
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	274 — Enzyme I; Chain A, domain 2
Homologous superfamily homologous superfamily	100 — RNA polymerase Rpb1, domain 3

Domain ID domain_id	4c3iA05
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	132 — Topoisomerase I; Chain A, domain 4
Homologous superfamily homologous superfamily	30 — RNA polymerase Rpb1 funnel domain

Domain ID domain_id	4c3iA07
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	357 — Tetracycline Repressor; domain 2
Homologous superfamily homologous superfamily	120 —

Domain ID domain_id	4c3iB04
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	1110 — Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3
Homologous superfamily homologous superfamily	10 — RNA polymerase Rpb2, domain 2

Domain ID domain_id	4c3iB05
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	1070 — Hypothetical Protein Ta0175; Chain: A, domain 2
Homologous superfamily homologous superfamily	20 —

Domain ID domain_id	4c3iB06
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	270 — Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6
Homologous superfamily homologous superfamily	10 — DNA-directed RNA polymerase, subunit 2, domain 6

Domain ID domain_id	4c3iB07
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	150 — RNA polymerase II, Rpb2 subunit, wall domain

Domain ID domain_id	4c3iB08
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	1800 — DCoH-like
Homologous superfamily homologous superfamily	10 — RNA polymerase alpha subunit dimerisation domain

Domain ID domain_id	4c3iC01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1360 — Gyrase A; domain 2
Homologous superfamily homologous superfamily	10 — RNA polymerase, RBP11-like subunit

Domain ID domain_id	4c3iC02
Class class	2 — Mainly Beta
Architecture architecture	170 — Beta Complex
Topology topology	120 — RNA Polymerase Alpha Subunit; Chain A, domain 2
Homologous superfamily homologous superfamily	12 — DNA-directed RNA polymerase, insert domain

Domain ID domain_id	4c3iD01
Class class	6 — Special
Architecture architecture	10 — Helix non-globular
Topology topology	250 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily	3390 —

Domain ID domain_id	4c3iE01
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	1340 — Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1
Homologous superfamily homologous superfamily	10 — RNA polymerase, Rpb5, N-terminal domain

Domain ID domain_id	4c3iE02
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	940 — Eukaryotic RPB6 RNA polymerase subunit
Homologous superfamily homologous superfamily	20 — RPB5-like RNA polymerase subunit

Domain ID domain_id	4c3iF00
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	940 — Eukaryotic RPB6 RNA polymerase subunit
Homologous superfamily homologous superfamily	10 — RNA polymerase subunit, RPB6/omega

Domain ID domain_id	4c3iG02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	1060 —

Domain ID domain_id	4c3iH00
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	140 — Nucleic acid-binding proteins

Domain ID domain_id	4c3iJ00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily	60 — Homeodomain-like

Domain ID domain_id	4c3iK00
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1360 — Gyrase A; domain 2
Homologous superfamily homologous superfamily	10 — RNA polymerase, RBP11-like subunit

Domain ID domain_id	4c3iL00
Class class	2 — Mainly Beta
Architecture architecture	20 — Single Sheet
Topology topology	28 — Rubrerythrin, domain 2
Homologous superfamily homologous superfamily	30 — RNA polymerase ii, chain L

▶

Unit-cell length a length_a	400.530 Å
Unit-cell length b length_b	140.220 Å
Unit-cell length c length_c	122.890 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	100.14 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	4

Space group space_group	C 1 2 1
Space-group number int_tables_number	5
Crystal system crystal_system	—

Resolution resolution	3.000 Å
Low-resolution limit resolution_low	84.000 Å
R factor r_factor	0.2001
R_work r_work	0.1985
R_free r_free	0.2307

Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100

1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer