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6hyu

Crystal structure of DHX8 helicase bound to single stranded poly-adenine RNA

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

ATP-dependent RNA helicase DHX8

Homo sapiens

UniProt Q14562

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Monomer Protein 1 RNA 1 ;RNA (5'-R(*AP*AP*AP*AP*AP*A)-3') ; × 1 1,2-ETHANEDIOL × 1 water × 2 Consistent with all polymers
2 Protein–RNA Monomer Protein 1 RNA 1 ;RNA (5'-R(*A*AP*A)-3') ; × 1 water × 1 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
2eqs 6hys 6hys 6hys 6hys 6hyt 6hyt 6hyt 6hyt

9 assemblies

Homodimer
3i4u

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5mqf 5xjc 6hyu 6hyu 6icz 6qdv 7w59 7w5a 7w5b 8c6j 9fmd

11 assemblies

View Construct and Data Evidence
UniProt name DHX8_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–673； UniProt 548–1220 Author chain C； PDBConstruct 1–673； UniProt 548–1220

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6hyu
Deposition date deposition_date2018-10-22
Structure title titleCrystal structure of DHX8 helicase bound to single stranded poly-adenine RNA
Keywords keywordsHelicase, Splicing, RNA, RNA BINDING PROTEIN; RNA BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6hyu__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6hyu__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6hyu__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）25.74 Å
Rg (electron density)24.96 Å
Total Rg25.82 Å
Atom count4679
Residues619
Excluded volume82866 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6hyu__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6hyu__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

Domain ID domain_id6hyuC01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
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7. Citations (1)