7w5b

The cryo-EM structure of human C* complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Pre-mRNA-processing-splicing factor 8

OrganismNot specified

UniProt Q6P2Q9

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PRP8_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 1–2335; UniProt 1–2335

116 kDa U5 small nuclear ribonucleoprotein component

OrganismNot specified

UniProt Q15029

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name U5S1_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C; PDBConstruct 1–972; UniProt 1–972

U5 small nuclear ribonucleoprotein 200 kDa helicase

OrganismNot specified

UniProt O75643

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name U520_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain D; PDBConstruct 1–2136; UniProt 1–2136

U5 small nuclear ribonucleoprotein 40 kDa protein

OrganismNot specified

UniProt Q96DI7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SNR40_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain E; PDBConstruct 1–357; UniProt 1–357

Pre-mRNA-splicing factor SYF1

OrganismNot specified

UniProt Q9HCS7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SYF1_HUMAN
Isoform —
PDB entities 10
Chains and sequence ranges Author chain I; PDBConstruct 1–855; UniProt 1–855

Crooked neck-like protein 1

OrganismNot specified

UniProt Q9BZJ0

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CRNL1_HUMAN
Isoform —
PDB entities 11
Chains and sequence ranges Author chain J; PDBConstruct 1–848; UniProt 1–848

Pre-mRNA-splicing factor SPF27

OrganismNot specified

UniProt O75934

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SPF27_HUMAN
Isoform —
PDB entities 12
Chains and sequence ranges Author chain K; PDBConstruct 1–225; UniProt 1–225

Cell division cycle 5-like protein

OrganismNot specified

UniProt Q99459

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CDC5L_HUMAN
Isoform —
PDB entities 13
Chains and sequence ranges Author chain L; PDBConstruct 1–802; UniProt 1–802

Pre-mRNA-splicing factor SYF2

OrganismNot specified

UniProt O95926

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SYF2_HUMAN
Isoform —
PDB entities 14
Chains and sequence ranges Author chain M; PDBConstruct 1–243; UniProt 1–243

Protein BUD31 homolog

OrganismNot specified

UniProt P41223

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name BUD31_HUMAN
Isoform —
PDB entities 15
Chains and sequence ranges Author chain N; PDBConstruct 1–144; UniProt 1–144

Pre-mRNA-splicing factor RBM22

OrganismNot specified

UniProt Q9NW64

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RBM22_HUMAN
Isoform —
PDB entities 16
Chains and sequence ranges Author chain O; PDBConstruct 1–420; UniProt 1–420

Spliceosome-associated protein CWC15 homolog

OrganismNot specified

UniProt Q9P013

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CWC15_HUMAN
Isoform —
PDB entities 17
Chains and sequence ranges Author chain P; PDBConstruct 1–229; UniProt 1–229

RNA helicase aquarius

OrganismNot specified

UniProt O60306

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name AQR_HUMAN
Isoform —
PDB entities 18
Chains and sequence ranges Author chain Q; PDBConstruct 1–1485; UniProt 1–1485

SNW domain-containing protein 1

OrganismNot specified

UniProt Q13573

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SNW1_HUMAN
Isoform —
PDB entities 19
Chains and sequence ranges Author chain R; PDBConstruct 1–536; UniProt 1–536

Peptidyl-prolyl cis-trans isomerase-like 1

OrganismNot specified

UniProt Q9Y3C6

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PPIL1_HUMAN
Isoform —
PDB entities 20
Chains and sequence ranges Author chain S; PDBConstruct 1–166; UniProt 1–166

Pleiotropic regulator 1

OrganismNot specified

UniProt O43660

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PLRG1_HUMAN
Isoform —
PDB entities 21
Chains and sequence ranges Author chain T; PDBConstruct 1–514; UniProt 1–514

Serine/arginine repetitive matrix protein 2

OrganismNot specified

UniProt Q9UQ35

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SRRM2_HUMAN
Isoform —
PDB entities 22
Chains and sequence ranges Author chain U; PDBConstruct 1–2752; UniProt 1–2752

Pre-mRNA-splicing factor CWC22 homolog

OrganismNot specified

UniProt Q9HCG8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CWC22_HUMAN
Isoform —
PDB entities 23
Chains and sequence ranges Author chain V; PDBConstruct 1–908; UniProt 1–908

Pre-mRNA-processing factor 17

OrganismNot specified

UniProt O60508

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PRP17_HUMAN
Isoform —
PDB entities 24
Chains and sequence ranges Author chain W; PDBConstruct 1–579; UniProt 1–579

ATP-dependent RNA helicase DHX8

OrganismNot specified

UniProt Q14562

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name DHX8_HUMAN
Isoform —
PDB entities 25
Chains and sequence ranges Author chain Y; PDBConstruct 1–1220; UniProt 1–1220

Cactin

OrganismNot specified

UniProt Q8WUQ7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CATIN_HUMAN
Isoform —
PDB entities 26
Chains and sequence ranges Author chain Z; PDBConstruct 1–758; UniProt 1–758

PRKR-interacting protein 1

OrganismNot specified

UniProt Q9H875

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PKRI1_HUMAN
Isoform —
PDB entities 27
Chains and sequence ranges Author chain 2; PDBConstruct 1–184; UniProt 1–184

Protein FAM32A

OrganismNot specified

UniProt Q9Y421

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name FA32A_HUMAN
Isoform —
PDB entities 28
Chains and sequence ranges Author chain z; PDBConstruct 1–112; UniProt 1–112

;Small nuclear ribonucleoprotein-associated proteins B and B' ;

OrganismNot specified

UniProt P14678

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RSMB_HUMAN
Isoform —
PDB entities 29
Chains and sequence ranges Author chain b; PDBConstruct 1–240; UniProt 1–240 Author chain i; PDBConstruct 1–240; UniProt 1–240

Peptidyl-prolyl cis-trans isomerase E

OrganismNot specified

UniProt Q9UNP9

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PPIE_HUMAN
Isoform —
PDB entities 30
Chains and sequence ranges Author chain y; PDBConstruct 1–301; UniProt 1–301

Small nuclear ribonucleoprotein Sm D3

OrganismNot specified

UniProt P62318

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SMD3_HUMAN
Isoform —
PDB entities 31
Chains and sequence ranges Author chain a; PDBConstruct 1–126; UniProt 1–126 Author chain h; PDBConstruct 1–126; UniProt 1–126

Small nuclear ribonucleoprotein Sm D1

OrganismNot specified

UniProt P62314

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SMD1_HUMAN
Isoform —
PDB entities 32
Chains and sequence ranges Author chain c; PDBConstruct 1–119; UniProt 1–119 Author chain j; PDBConstruct 1–119; UniProt 1–119

Small nuclear ribonucleoprotein Sm D2

OrganismNot specified

UniProt P62316

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SMD2_HUMAN
Isoform —
PDB entities 33
Chains and sequence ranges Author chain d; PDBConstruct 1–118; UniProt 1–118 Author chain k; PDBConstruct 1–118; UniProt 1–118

Small nuclear ribonucleoprotein F

OrganismNot specified

UniProt P62306

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RUXF_HUMAN
Isoform —
PDB entities 34
Chains and sequence ranges Author chain f; PDBConstruct 1–86; UniProt 1–86 Author chain m; PDBConstruct 1–86; UniProt 1–86

Small nuclear ribonucleoprotein E

OrganismNot specified

UniProt P62304

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RUXE_HUMAN
Isoform —
PDB entities 35
Chains and sequence ranges Author chain e; PDBConstruct 1–92; UniProt 1–92 Author chain l; PDBConstruct 1–92; UniProt 1–92

Small nuclear ribonucleoprotein G

OrganismNot specified

UniProt P62308

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RUXG_HUMAN
Isoform —
PDB entities 36
Chains and sequence ranges Author chain g; PDBConstruct 1–76; UniProt 1–76 Author chain n; PDBConstruct 1–76; UniProt 1–76

Pre-mRNA-processing factor 19

OrganismNot specified

UniProt Q9UMS4

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PRP19_HUMAN
Isoform —
PDB entities 37
Chains and sequence ranges Author chain q; PDBConstruct 1–504; UniProt 1–504 Author chain r; PDBConstruct 1–504; UniProt 1–504 Author chain s; PDBConstruct 1–504; UniProt 1–504 Author chain t; PDBConstruct 1–504; UniProt 1–504

;U2 small nuclear ribonucleoprotein A' ;

OrganismNot specified

UniProt P09661

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RU2A_HUMAN
Isoform —
PDB entities 38
Chains and sequence ranges Author chain o; PDBConstruct 1–255; UniProt 1–255

;U2 small nuclear ribonucleoprotein B'' ;

OrganismNot specified

UniProt P08579

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RU2B_HUMAN
Isoform —
PDB entities 39
Chains and sequence ranges Author chain p; PDBConstruct 1–225; UniProt 1–225

Pre-mRNA-splicing factor SLU7

OrganismNot specified

UniProt O95391

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SLU7_HUMAN
Isoform —
PDB entities 40
Chains and sequence ranges Author chain 1; PDBConstruct 1–586; UniProt 1–586

Protein mago nashi homolog

OrganismNot specified

UniProt P61326

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name MGN_HUMAN
Isoform —
PDB entities 41
Chains and sequence ranges Author chain v; PDBConstruct 1–146; UniProt 1–146

RNA-binding protein 8A

OrganismNot specified

UniProt Q9Y5S9

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RBM8A_HUMAN
Isoform —
PDB entities 42
Chains and sequence ranges Author chain w; PDBConstruct 1–174; UniProt 1–174

Eukaryotic initiation factor 4A-III

OrganismNot specified

UniProt P38919

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Protein CASC3 × 1 (O15234) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name IF4A3_HUMAN
Isoform —
PDB entities 43
Chains and sequence ranges Author chain u; PDBConstruct 1–411; UniProt 1–411

Protein CASC3

OrganismNot specified

UniProt O15234

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) NF-kappa-B-activating protein × 1 (Q8N5F7) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CASC3_HUMAN
Isoform —
PDB entities 44
Chains and sequence ranges Author chain x; PDBConstruct 1–703; UniProt 1–703

NF-kappa-B-activating protein

OrganismNot specified

UniProt Q8N5F7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 50 RNA 5 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U6 snRNA × 1 Pre-mRNA × 1 Pre-mRNA × 1 U2 snRNA × 1 Pre-mRNA-splicing factor SYF1 × 1 (Q9HCS7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor SPF27 × 1 (O75934) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor SYF2 × 1 (O95926) Protein BUD31 homolog × 1 (P41223) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) RNA helicase aquarius × 1 (O60306) SNW domain-containing protein 1 × 1 (Q13573) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) Pleiotropic regulator 1 × 1 (O43660) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Pre-mRNA-processing factor 17 × 1 (O60508) ATP-dependent RNA helicase DHX8 × 1 (Q14562) Cactin × 1 (Q8WUQ7) PRKR-interacting protein 1 × 1 (Q9H875) Protein FAM32A × 1 (Q9Y421) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 2 (P14678) Peptidyl-prolyl cis-trans isomerase E × 1 (Q9UNP9) Small nuclear ribonucleoprotein Sm D3 × 2 (P62318) Small nuclear ribonucleoprotein Sm D1 × 2 (P62314) Small nuclear ribonucleoprotein Sm D2 × 2 (P62316) Small nuclear ribonucleoprotein F × 2 (P62306) Small nuclear ribonucleoprotein E × 2 (P62304) Small nuclear ribonucleoprotein G × 2 (P62308) Pre-mRNA-processing factor 19 × 4 (Q9UMS4) ;U2 small nuclear ribonucleoprotein A' ; × 1 (P09661) ;U2 small nuclear ribonucleoprotein B'' ; × 1 (P08579) Pre-mRNA-splicing factor SLU7 × 1 (O95391) Protein mago nashi homolog × 1 (P61326) RNA-binding protein 8A × 1 (Q9Y5S9) Eukaryotic initiation factor 4A-III × 1 (P38919) Protein CASC3 × 1 (O15234) INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 9 ZINC ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name NKAP_HUMAN
Isoform —
PDB entities 45
Chains and sequence ranges Author chain 3; PDBConstruct 1–415; UniProt 1–415

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7w5b
Deposition date deposition_date2021-11-29
Structure title titleThe cryo-EM structure of human C* complex
Keywords keywordsspliceosome, C* complex, RNA splicing, PRP22, exon ligation, SPLICING; SPLICING
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7w5b__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7w5b__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7w5b__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)97.91 Å
Rg (electron density)96.88 Å
Total Rg95.61 Å
Atom count106510
Residues15024
Excluded volume1812000 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7w5b__assembly_1__model_1 55-meric (55) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (50)

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7. Citations (1)