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7rsc

NMR-driven structure of the KRAS4B-G12D "alpha-alpha" dimer on a lipid bilayer nanodisc

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

GTPase KRas

Homo sapiens

UniProt P01116

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Apolipoprotein A-I × 2 （P02647） 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 2 MAGNESIUM ION × 2 [(2~{R})-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-2-propanoyloxy-propyl] (~{Z})-octadec-9-enoate × 128 O-[(S)-({(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-L-serine × 32 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
10jt 10jt 10nu 10nu 10nv 10nv 11qe 3gft 3gft 3gft 3gft 3gft

512 assemblies; showing the first 12

Homodimer
4lrw 4luc 4lv6 4pzy 5v6v 5whd 5whd 6bof 6m9w 6quv 6quw 6qux

22 assemblies; showing the first 12

Homotetramer
8stm

1 assemblies

Other homooligomers
4lyf 4lyh 5oco 5oct 6f76 6fa1 6gog 7acq

8 assemblies

Heteromeric or nucleic-acid complex
1d8d 1d8e 24hr 24hr 24hr 24hr 24hs 24hs 24hs 24hs 24hs 24hs

262 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RASK_HUMAN
Isoform P01116-2
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–185； UniProt 2–185 Author chain B； PDBConstruct 2–185； UniProt 2–185

Apolipoprotein A-I

Homo sapiens

UniProt P02647

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 GTPase KRas × 2 （P01116） 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 2 MAGNESIUM ION × 2 [(2~{R})-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-2-propanoyloxy-propyl] (~{Z})-octadec-9-enoate × 128 O-[(S)-({(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-L-serine × 32 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1gw3 1gw4 1odp 1odq 1odr

5 assemblies

Homodimer
2n5e 3k2s 3r2p

3 assemblies

Homotetramer
1av1

1 assemblies

Other homooligomers
9pvy 9pvz 9pw3

3 assemblies

Heteromeric or nucleic-acid complex
2msc 2msd 2mse 4v6m 6cc9 6cch 6ccx 6clz 6cm1 6pts 6ptw 6w4e

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name APOA1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain D； PDBConstruct 3–200； UniProt 68–265 Author chain E； PDBConstruct 3–200； UniProt 68–265

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7rsc
Deposition date deposition_date2021-08-11
Structure title titleNMR-driven structure of the KRAS4B-G12D "alpha-alpha" dimer on a lipid bilayer nanodisc
Keywords keywordsnanodisc, ONCOPROTEIN; ONCOPROTEIN
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7rsc__assembly_1__model_20

Assembly 1 · Model 20 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7rsc__assembly_1__model_20 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7rsc__assembly_1__model_20 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）46.92 Å
Rg (electron density)42.93 Å
Total Rg42.39 Å
Atom count14322
Residues740
Excluded volume253940 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7rsc__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 7rsc__assembly_1__model_2 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 7rsc__assembly_1__model_3 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 7rsc__assembly_1__model_4 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 7rsc__assembly_1__model_5 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 7rsc__assembly_1__model_6 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 7rsc__assembly_1__model_7 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 7rsc__assembly_1__model_8 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 7rsc__assembly_1__model_9 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 7rsc__assembly_1__model_10 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 7rsc__assembly_1__model_11 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 7rsc__assembly_1__model_12 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 7rsc__assembly_1__model_13 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 7rsc__assembly_1__model_14 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 7rsc__assembly_1__model_15 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 7rsc__assembly_1__model_16 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 7rsc__assembly_1__model_17 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 7rsc__assembly_1__model_18 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 7rsc__assembly_1__model_19 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 7rsc__assembly_1__model_20 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

Domain ID domain_id7rscA01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id7rscB01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
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7. Citations (1)