← Back to search
8ek1

Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(dominant class)

Method: ELECTRON MICROSCOPY Dmax: 136.1 Å Quality: GOOD
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

Circumsporozoite protein

Plasmodium falciparum 3D7

UniProt Q7K740

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 7 PDB declaration: heptameric（7） Consistent with protein copy count Chain P； UniProt 21–375 Mutation：C-79S, K-38S, K-37S, R-34A L9 Fab heavy chain × 3 L9 Fab light chain × 3 ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.60 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 8EK1 Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
3VDJ Crystal structure of circumsporozoite protein aTSR domain, R32 native form Deposited 2012-01-05 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4；295 K；0.1 M citrate, pH 4.0, 1 M lithium chloride, 20% PEG6000, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.70 Å R-free 0.200
3VDJ Crystal structure of circumsporozoite protein aTSR domain, R32 native form Deposited 2012-01-05 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4；295 K；0.1 M citrate, pH 4.0, 1 M lithium chloride, 20% PEG6000, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.70 Å R-free 0.200
3VDK Crystal structure of circumsporozoite protein aTSR domain, R32 platinum-bound form Deposited 2012-01-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)
Not recorded PT PLATINUM (II) ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4；295 K；0.1 M citrate, pH 4.0, 1 M lithium chloride, 20% PEG6000, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.85 Å R-free 0.217
3VDK Crystal structure of circumsporozoite protein aTSR domain, R32 platinum-bound form Deposited 2012-01-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)
Not recorded PT PLATINUM (II) ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4；295 K；0.1 M citrate, pH 4.0, 1 M lithium chloride, 20% PEG6000, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.85 Å R-free 0.217
3VDL Crystal structure of circumsporozoite protein aTSR domain, P43212 form Deposited 2012-01-05 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.1；295 K；1.4 M sodium citrate, pH 6.1, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.04 Å R-free 0.240
3VDL Crystal structure of circumsporozoite protein aTSR domain, P43212 form Deposited 2012-01-05 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.1；295 K；1.4 M sodium citrate, pH 6.1, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.04 Å R-free 0.240
3VDL Crystal structure of circumsporozoite protein aTSR domain, P43212 form Deposited 2012-01-05 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.1；295 K；1.4 M sodium citrate, pH 6.1, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.04 Å R-free 0.240
3VDL Crystal structure of circumsporozoite protein aTSR domain, P43212 form Deposited 2012-01-05 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)
Chain B 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)
Chain C 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.1；295 K；1.4 M sodium citrate, pH 6.1, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.04 Å R-free 0.240
7RXI Fab234 in complex with the C-terminal alpha-TSR domain of P. falciparum Deposited 2021-08-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 310–375（66 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 310-375)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；20% PEG8000, 0.1 M HEPES, pH 7.5
Resolution 2.15 Å R-free 0.265
7RXJ Fab236 in complex with the C-terminal alpha-TSR domain of P. falciparum Deposited 2021-08-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain G 310–375（66 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 310-375)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.6；293.15 K；30% PEG2000 MME, 0.2 M ammonium sulfate, 0.1 M acetate, pH 4.6
Resolution 2.35 Å R-free 0.249
7RXJ Fab236 in complex with the C-terminal alpha-TSR domain of P. falciparum Deposited 2021-08-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain I 310–375（66 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 310-375)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.6；293.15 K；30% PEG2000 MME, 0.2 M ammonium sulfate, 0.1 M acetate, pH 4.6
Resolution 2.35 Å R-free 0.249
7RXL Fab1488 in complex with the C-terminal alpha-TSR domain of P. falciparum Deposited 2021-08-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain E 310–375（66 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 310-375)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.9；293.15 K；20% PEG3350, 0.2 M potassium chloride, pH 6.9
Resolution 1.82 Å R-free 0.255
7RXL Fab1488 in complex with the C-terminal alpha-TSR domain of P. falciparum Deposited 2021-08-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain F 310–375（66 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 310-375)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.9；293.15 K；20% PEG3350, 0.2 M potassium chloride, pH 6.9
Resolution 1.82 Å R-free 0.255
7RXP Fab1512 in complex with the C-terminal alpha-TSR domain of P. falciparum Deposited 2021-08-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 309–375（67 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 309-375)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；20% PEG3000, 0.2 M sodium chloride, 0.1 M HEPES. pH 7.5
Resolution 1.76 Å R-free 0.205
7S0X Fab352 in complex with the C-terminal alphaTSR domain of P. falciparum Deposited 2021-08-31 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain E 310–375（66 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 310-375)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.6；293.15 K；20% isopropanol, 20% PEG4000, 0.1 M sodium citrate, pH 5.6
Resolution 2.80 Å R-free 0.276
7S0X Fab352 in complex with the C-terminal alphaTSR domain of P. falciparum Deposited 2021-08-31 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain F 310–375（66 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 310-375)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.6；293.15 K；20% isopropanol, 20% PEG4000, 0.1 M sodium citrate, pH 5.6
Resolution 2.80 Å R-free 0.276
7V05 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Deposited 2022-05-09 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric
Chain X 20–384（365 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.40 Å
8EKA Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(class 2) Deposited 2022-09-20 Different mutation/modification Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain P 21–375（355 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
8FG0 Crystal structure of the 3764 Fab in complex with the C-terminal PfCSP linker, PfCSP281-294. Deposited 2022-12-11 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain P 281–294（14 aa） Fragment：residues 281-294
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；19% (v/v) isopropanol, 19% (w/v) PEG 4000, 5% (v/v) glycerol, 0.095 M sodium citrate, pH 5.6
Resolution 2.36 Å R-free 0.237
8FG0 Crystal structure of the 3764 Fab in complex with the C-terminal PfCSP linker, PfCSP281-294. Deposited 2022-12-11 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain Q 281–294（14 aa） Fragment：residues 281-294
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；19% (v/v) isopropanol, 19% (w/v) PEG 4000, 5% (v/v) glycerol, 0.095 M sodium citrate, pH 5.6
Resolution 2.36 Å R-free 0.237
9C79 Human monoclonal antibody MAD21-101 bound to the N-terminus of cleaved circumsporozoite protein Deposited 2024-06-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric
Chain D 96–113（18 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) EDO 1,2-ETHANEDIOL × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；2.0 M ammonium sulfate, 0.2 M sodium chloride, 0.1 M cacodylate
Resolution 1.46 Å R-free 0.200
9C7D Human monoclonal antibody MAD22-38 bound to the N-terminus of cleaved circumsporozoite protein Deposited 2024-06-10 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 96–113（18 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；20% PEG 3350, 0.2 M ammonium chloride
Resolution 1.99 Å R-free 0.232
9C7F Human monoclonal antibody MAD24-01 bound to the N-terminus of cleaved circumsporozoite protein Deposited 2024-06-10 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric
Chain J 96–113（18 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；20% PEG 3350 and 0.2 M potassium fluoride
Resolution 1.82 Å R-free 0.238
9C7F Human monoclonal antibody MAD24-01 bound to the N-terminus of cleaved circumsporozoite protein Deposited 2024-06-10 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Other combination Heteromer；Protein × 3 PDB declaration: trimeric
Chain G 96–113（18 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；20% PEG 3350 and 0.2 M potassium fluoride
Resolution 1.82 Å R-free 0.238
9C7F Human monoclonal antibody MAD24-01 bound to the N-terminus of cleaved circumsporozoite protein Deposited 2024-06-10 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Other combination Heteromer；Protein × 3 PDB declaration: trimeric
Chain I 96–113（18 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；20% PEG 3350 and 0.2 M potassium fluoride
Resolution 1.82 Å R-free 0.238
9C7F Human monoclonal antibody MAD24-01 bound to the N-terminus of cleaved circumsporozoite protein Deposited 2024-06-10 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Other combination Heteromer；Protein × 3 PDB declaration: trimeric
Chain Q 96–113（18 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；20% PEG 3350 and 0.2 M potassium fluoride
Resolution 1.82 Å R-free 0.238
9CCA Cryo-EM structure of a designed pyridoxal phosphate (PLP) synthase fused to a designed circumsporozoite protein antigen from Plasmodium falciparum (CSP-P1-CSP and CSP-P2-CSP) Deposited 2024-06-21 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 24 PDB declaration: 24-meric
Chain A 101–114（14 aa）
Chain A 131–150（20 aa）
Chain A 310–383（74 aa）
Chain B 101–114（14 aa）
Chain B 131–150（20 aa）
Chain B 310–383（74 aa）
Chain C 101–114（14 aa）
Chain C 131–150（20 aa）
Chain C 310–383（74 aa）
Chain D 101–114（14 aa）
Chain D 131–150（20 aa）
Chain D 310–383（74 aa）
Chain E 101–114（14 aa）
Chain E 131–150（20 aa）
Chain E 310–383（74 aa）
Chain F 101–114（14 aa）
Chain F 131–150（20 aa）
Chain F 310–383（74 aa）
Chain G 101–114（14 aa）
Chain G 131–150（20 aa）
Chain G 310–383（74 aa）
Chain H 101–114（14 aa）
Chain H 131–150（20 aa）
Chain H 310–383（74 aa）
Chain I 101–114（14 aa）
Chain I 131–150（20 aa）
Chain I 310–383（74 aa）
Chain J 101–114（14 aa）
Chain J 131–150（20 aa）
Chain J 310–383（74 aa）
Chain K 101–114（14 aa）
Chain K 131–150（20 aa）
Chain K 310–383（74 aa）
Chain L 101–114（14 aa）
Chain L 131–150（20 aa）
Chain L 310–383（74 aa）
Chain M 101–114（14 aa）
Chain M 131–150（20 aa）
Chain M 310–383（74 aa）
Chain N 101–114（14 aa）
Chain N 131–150（20 aa）
Chain N 310–383（74 aa）
Chain O 101–114（14 aa）
Chain O 131–150（20 aa）
Chain O 310–383（74 aa）
Chain P 101–114（14 aa）
Chain P 131–150（20 aa）
Chain P 310–383（74 aa）
Chain Q 101–114（14 aa）
Chain Q 131–150（20 aa）
Chain Q 310–383（74 aa）
Chain R 101–114（14 aa）
Chain R 131–150（20 aa）
Chain R 310–383（74 aa）
Chain S 101–114（14 aa）
Chain S 131–150（20 aa）
Chain S 310–383（74 aa）
Chain T 101–114（14 aa）
Chain T 131–150（20 aa）
Chain T 310–383（74 aa）
Chain U 101–114（14 aa）
Chain U 131–150（20 aa）
Chain U 310–383（74 aa）
Chain V 101–114（14 aa）
Chain V 131–150（20 aa）
Chain V 310–383（74 aa）
Chain W 101–114（14 aa）
Chain W 131–150（20 aa）
Chain W 310–383（74 aa）
Chain X 101–114（14 aa）
Chain X 131–150（20 aa）
Chain X 310–383（74 aa）
Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.95 Å
9DSR Crystal structure of Fab MS-1805 in complex with NPNA3 peptide from circumsporozoite protein Deposited 2024-09-28 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 131–142（12 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M Zinc acetate, 20% (w/v) polyethylene glycol
Resolution 2.25 Å R-free 0.239
9DSS Crystal structure of Fab 7088 in complex with NPNA3 peptide from circumsporozoite protein Deposited 2024-09-28 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 131–142（12 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.2 M sodium chloride and 20% (w/v) polyethylene glycol 3350
Resolution 2.00 Å R-free 0.263
9DST Crystal structure of Fab MS-1805 in complex with N-terminal junction peptide from circumsporozoite protein Deposited 2024-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 95–110（16 aa）
Not recorded CIT CITRIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.1 M sodium citrate, 20% (v/v) 2-propanol and 20% (w/v) polyethylene glycol 4000
Resolution 1.74 Å R-free 0.228
9DSU Crystal structure of Fab 7088 in complex with N-terminal junction peptide from circumsporozoite protein Deposited 2024-09-28 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 95–110（16 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293.15 K；0.1 M Tris pH 8.0, 1M lithium chloride and 10% (w/v) polyethylene glycol 6000
Resolution 3.14 Å R-free 0.275
9NCY Fab1392 in complex with the C-terminal alpha-TSR domain of the P. falciparum circumsporozoite protein Deposited 2025-02-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 310–376（67 aa）
Not recorded PEG DI(HYDROXYETHYL)ETHER × 5 GOL GLYCEROL × 8 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；30% PEG-600, 10% (v/v) glycerol, 0.5 M NH4-sulfate, 0.1 M Tris pH 7.0, final pH 5.6.
Resolution 1.63 Å R-free 0.194
9NKZ Crystal structure of Fab MAM01 in complex with NANP6 peptide from circumsporozoite protein Deposited 2025-03-02 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 129–152（24 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.04 M potassium dihydrogen phosphate, 20% (v/v) glycerol and 16% (w/v) polyethylene glycol 8000
Resolution 1.48 Å R-free 0.210
9NL0 Crystal structure of Fab MAM01 in complex with NPNA3 peptide from circumsporozoite protein Deposited 2025-03-02 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 131–142（12 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.1 M Bicine pH 9.0 and 65% (v/v) 2-methyl-2,4-pentanediol
Resolution 1.54 Å R-free 0.202
9NL1 Crystal structure of Fab MAM01 in complex with junctional region peptide from circumsporozoite protein Deposited 2025-03-02 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 101–114（14 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.085 M Tris pH 8.5, 0.17 M sodium acetate, 15% (v/v) glycerol and 25.5 % (w/v) polyethylene glycol 4000
Resolution 2.71 Å R-free 0.313
9NZF Crystal structure of Fab MAM01 in complex with minor repeat region peptide from circumsporozoite protein Deposited 2025-03-31 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 109–128（20 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.2 M potassium acetate, pH 7.8 and 20% (w/v) polyethylene glycol 3350
Resolution 1.84 Å R-free 0.230
9ZM7 Crystal structure of Fab 7160 in complex with junctional region from circumsporozoite protein Deposited 2025-12-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain K 101–116（16 aa）
Chain L 101–116（16 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.2 M sodium dihydrogen phosphate (pH 4.5) and 20% (w/v) polyethylene glycol (PEG) 3350
Resolution 2.30 Å R-free 0.275
9ZM7 Crystal structure of Fab 7160 in complex with junctional region from circumsporozoite protein Deposited 2025-12-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 101–116（16 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.2 M sodium dihydrogen phosphate (pH 4.5) and 20% (w/v) polyethylene glycol (PEG) 3350
Resolution 2.30 Å R-free 0.275
9ZM7 Crystal structure of Fab 7160 in complex with junctional region from circumsporozoite protein Deposited 2025-12-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain F 101–116（16 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.2 M sodium dihydrogen phosphate (pH 4.5) and 20% (w/v) polyethylene glycol (PEG) 3350
Resolution 2.30 Å R-free 0.275
9ZM7 Crystal structure of Fab 7160 in complex with junctional region from circumsporozoite protein Deposited 2025-12-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain O 101–116（16 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.2 M sodium dihydrogen phosphate (pH 4.5) and 20% (w/v) polyethylene glycol (PEG) 3350
Resolution 2.30 Å R-free 0.275
9ZM7 Crystal structure of Fab 7160 in complex with junctional region from circumsporozoite protein Deposited 2025-12-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 6 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain R 101–116（16 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.2 M sodium dihydrogen phosphate (pH 4.5) and 20% (w/v) polyethylene glycol (PEG) 3350
Resolution 2.30 Å R-free 0.275
9ZM7 Crystal structure of Fab 7160 in complex with junctional region from circumsporozoite protein Deposited 2025-12-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 7 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain U 101–116（16 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.2 M sodium dihydrogen phosphate (pH 4.5) and 20% (w/v) polyethylene glycol (PEG) 3350
Resolution 2.30 Å R-free 0.275
9ZM7 Crystal structure of Fab 7160 in complex with junctional region from circumsporozoite protein Deposited 2025-12-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 8 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain X 101–116（16 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.2 M sodium dihydrogen phosphate (pH 4.5) and 20% (w/v) polyethylene glycol (PEG) 3350
Resolution 2.30 Å R-free 0.275
9ZM8 Crystal structure of 7160 in complex with minor repeat region from circumsporozoite protein Deposited 2025-12-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain C 109–128（20 aa）
Chain D 109–128（20 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M HEPES (pH 7.0), 1 M lithium chloride, and 20% (w/v) PEG 6000.
Resolution 2.27 Å R-free 0.286
9ZM9 Crystal structure of Fab 7160 in complex with short major repeat region (NPNA3) from circumsporozoite protein Deposited 2025-12-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 131–142（12 aa）
Chain F 131–142（12 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.2 M sodium acetate (pH 7.0) and 20% (w/v) PEG 3350.
Resolution 1.88 Å R-free 0.245
9ZMA Crystal structure of Fab 7160 in complex with major repeat region (NANP6)from circumsporozoite protein Deposited 2025-12-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain I 129–152（24 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M magnesium nitrate (pH 5.8) and 20% (w/v) PEG 3350.
Resolution 2.33 Å R-free 0.236
9ZMA Crystal structure of Fab 7160 in complex with major repeat region (NANP6)from circumsporozoite protein Deposited 2025-12-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain J 129–152（24 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M magnesium nitrate (pH 5.8) and 20% (w/v) PEG 3350.
Resolution 2.33 Å R-free 0.236
9ZMB Crystal structure of Fab 7118 in complex with minor repeat region from circumsporozoite protein Deposited 2025-12-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 109–128（20 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M HEPES (pH 7.5), 30% (v/v) 1,2-propanediol, and 20% (v/v) PEG 400
Resolution 2.09 Å R-free 0.243
9ZMC Crystal structure of Fab 7118 in complex with major repeat region (NANP6) from circumsporozoite protein Deposited 2025-12-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 129–152（24 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate (pH 6.5), 0.16 M calcium acetate, 14.4% (w/v) PEG 8000, and 20% (v/v) glycerol
Resolution 2.00 Å R-free 0.217

30 other PDB entries and 49 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name CSP_PLAF7
Isoform —
PDB entities 3
Chains and sequence ranges Author chain P； PDBConstruct 1–355； UniProt 21–375

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 8ek1

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 8ek1
Download Download
▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id8ek1
Deposition date deposition_date2022-09-19
Structure title titleCryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(dominant class)
Keywords keywordsAnti-Malarial, PfCSP, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method methodELECTRON MICROSCOPY
▼

3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier41.88 Å
Radius of gyration Rg (electron density) rg_electron41.85 Å
Forward intensity I(0) i0225629000.00
Molecular weight molecular_weight120510.0 kDa
Excluded volume excluded_volume150120 ų
Envelope volume envelope_volume227670 ų
Hydration-shell volume shell_volume47828 ų
Envelope diameter envelope_diameter139.1 Å
Shell Rg shell_rg44.19 Å
Envelope Rg envelope_rg41.05 Å
Shape Rg shape_rg41.80 Å
Total Rg total_rg42.17 Å
Total atoms total_atoms8497
Residues n_residues1102
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
▼

4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax136.1 Å
Rg (real space) rg_real41.92 Å
Rg uncertainty (real space) rg_real_error1.19 Å
I(0) (real space) i0_real2.2560e+08
I(0) uncertainty (real space) i0_real_error4.0180e+06
Rg (reciprocal space) rg_reciprocal41.88 Å
I(0) (reciprocal space) i0_reciprocal225600000.0000
Solution quality estimate total_estimate0.8846
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks1
Primary peak position r_peak_primary43.0 Å
Skewness Skewness skewness0.253
Kurtosis Kurtosis kurtosis-0.674
Angular range angular_range— – 0.1900 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha15890000.0000
Real-space data points n_real_points39
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.932; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.981; Smooth: 0.719
▶

5. Crystallography and Experiment 5. Crystallography & Experiment

▶

6. Entities and Polymers Entities & Polymers (3)

▼

7. Fold Classification (SCOP + CATH) 8 domains

CATH v4.4 (8 domains)

Domain ID domain_id8ek1A01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id8ek1C01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id8ek1C02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id8ek1D01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id8ek1H01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id8ek1H02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id8ek1L01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id8ek1L02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
▶

8. Citations (1)

▶

9. Files and Curves (10)