8f2u

Human CCC complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

COMM domain-containing protein 1

Homo sapiens

UniProt Q8N668

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 COMM domain-containing protein 2 × 1 (Q86X83) COMM domain-containing protein 3 × 1 (Q9UBI1) COMM domain-containing protein 4 × 1 (Q9H0A8) COMM domain-containing protein 5 × 1 (Q9GZQ3) COMM domain-containing protein 6 × 1 (Q7Z4G1) COMM domain-containing protein 7 × 1 (Q86VX2) COMM domain-containing protein 8 × 1 (Q9NX08) COMM domain-containing protein 9 × 1 (Q9P000) COMM domain-containing protein 10 × 1 (Q9Y6G5) Coiled-coil domain-containing protein 93 × 1 (Q567U6) Coiled-coil domain-containing protein 22 × 1 (O60826) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name COMD1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 1–190; UniProt 1–190

COMM domain-containing protein 2

Homo sapiens

UniProt Q86X83

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 COMM domain-containing protein 1 × 1 (Q8N668) COMM domain-containing protein 3 × 1 (Q9UBI1) COMM domain-containing protein 4 × 1 (Q9H0A8) COMM domain-containing protein 5 × 1 (Q9GZQ3) COMM domain-containing protein 6 × 1 (Q7Z4G1) COMM domain-containing protein 7 × 1 (Q86VX2) COMM domain-containing protein 8 × 1 (Q9NX08) COMM domain-containing protein 9 × 1 (Q9P000) COMM domain-containing protein 10 × 1 (Q9Y6G5) Coiled-coil domain-containing protein 93 × 1 (Q567U6) Coiled-coil domain-containing protein 22 × 1 (O60826) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name COMD2_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B; PDBConstruct 1–199; UniProt 1–199

COMM domain-containing protein 3

Homo sapiens

UniProt Q9UBI1

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 COMM domain-containing protein 1 × 1 (Q8N668) COMM domain-containing protein 2 × 1 (Q86X83) COMM domain-containing protein 4 × 1 (Q9H0A8) COMM domain-containing protein 5 × 1 (Q9GZQ3) COMM domain-containing protein 6 × 1 (Q7Z4G1) COMM domain-containing protein 7 × 1 (Q86VX2) COMM domain-containing protein 8 × 1 (Q9NX08) COMM domain-containing protein 9 × 1 (Q9P000) COMM domain-containing protein 10 × 1 (Q9Y6G5) Coiled-coil domain-containing protein 93 × 1 (Q567U6) Coiled-coil domain-containing protein 22 × 1 (O60826) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name COMD3_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C; PDBConstruct 1–195; UniProt 1–195

COMM domain-containing protein 4

Homo sapiens

UniProt Q9H0A8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 COMM domain-containing protein 1 × 1 (Q8N668) COMM domain-containing protein 2 × 1 (Q86X83) COMM domain-containing protein 3 × 1 (Q9UBI1) COMM domain-containing protein 5 × 1 (Q9GZQ3) COMM domain-containing protein 6 × 1 (Q7Z4G1) COMM domain-containing protein 7 × 1 (Q86VX2) COMM domain-containing protein 8 × 1 (Q9NX08) COMM domain-containing protein 9 × 1 (Q9P000) COMM domain-containing protein 10 × 1 (Q9Y6G5) Coiled-coil domain-containing protein 93 × 1 (Q567U6) Coiled-coil domain-containing protein 22 × 1 (O60826) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name COMD4_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain D; PDBConstruct 1–199; UniProt 1–199

COMM domain-containing protein 5

Homo sapiens

UniProt Q9GZQ3

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 COMM domain-containing protein 1 × 1 (Q8N668) COMM domain-containing protein 2 × 1 (Q86X83) COMM domain-containing protein 3 × 1 (Q9UBI1) COMM domain-containing protein 4 × 1 (Q9H0A8) COMM domain-containing protein 6 × 1 (Q7Z4G1) COMM domain-containing protein 7 × 1 (Q86VX2) COMM domain-containing protein 8 × 1 (Q9NX08) COMM domain-containing protein 9 × 1 (Q9P000) COMM domain-containing protein 10 × 1 (Q9Y6G5) Coiled-coil domain-containing protein 93 × 1 (Q567U6) Coiled-coil domain-containing protein 22 × 1 (O60826) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name COMD5_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain E; PDBConstruct 1–224; UniProt 1–224

COMM domain-containing protein 6

Homo sapiens

UniProt Q7Z4G1

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 COMM domain-containing protein 1 × 1 (Q8N668) COMM domain-containing protein 2 × 1 (Q86X83) COMM domain-containing protein 3 × 1 (Q9UBI1) COMM domain-containing protein 4 × 1 (Q9H0A8) COMM domain-containing protein 5 × 1 (Q9GZQ3) COMM domain-containing protein 7 × 1 (Q86VX2) COMM domain-containing protein 8 × 1 (Q9NX08) COMM domain-containing protein 9 × 1 (Q9P000) COMM domain-containing protein 10 × 1 (Q9Y6G5) Coiled-coil domain-containing protein 93 × 1 (Q567U6) Coiled-coil domain-containing protein 22 × 1 (O60826) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name COMD6_HUMAN
Isoform —
PDB entities 6
Chains and sequence ranges Author chain F; PDBConstruct 1–85; UniProt 1–85

COMM domain-containing protein 7

Homo sapiens

UniProt Q86VX2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 COMM domain-containing protein 1 × 1 (Q8N668) COMM domain-containing protein 2 × 1 (Q86X83) COMM domain-containing protein 3 × 1 (Q9UBI1) COMM domain-containing protein 4 × 1 (Q9H0A8) COMM domain-containing protein 5 × 1 (Q9GZQ3) COMM domain-containing protein 6 × 1 (Q7Z4G1) COMM domain-containing protein 8 × 1 (Q9NX08) COMM domain-containing protein 9 × 1 (Q9P000) COMM domain-containing protein 10 × 1 (Q9Y6G5) Coiled-coil domain-containing protein 93 × 1 (Q567U6) Coiled-coil domain-containing protein 22 × 1 (O60826) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name COMD7_HUMAN
Isoform —
PDB entities 7
Chains and sequence ranges Author chain G; PDBConstruct 1–200; UniProt 1–200

COMM domain-containing protein 8

Homo sapiens

UniProt Q9NX08

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 COMM domain-containing protein 1 × 1 (Q8N668) COMM domain-containing protein 2 × 1 (Q86X83) COMM domain-containing protein 3 × 1 (Q9UBI1) COMM domain-containing protein 4 × 1 (Q9H0A8) COMM domain-containing protein 5 × 1 (Q9GZQ3) COMM domain-containing protein 6 × 1 (Q7Z4G1) COMM domain-containing protein 7 × 1 (Q86VX2) COMM domain-containing protein 9 × 1 (Q9P000) COMM domain-containing protein 10 × 1 (Q9Y6G5) Coiled-coil domain-containing protein 93 × 1 (Q567U6) Coiled-coil domain-containing protein 22 × 1 (O60826) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name COMD8_HUMAN
Isoform —
PDB entities 8
Chains and sequence ranges Author chain H; PDBConstruct 1–183; UniProt 1–183

COMM domain-containing protein 9

Homo sapiens

UniProt Q9P000

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 COMM domain-containing protein 1 × 1 (Q8N668) COMM domain-containing protein 2 × 1 (Q86X83) COMM domain-containing protein 3 × 1 (Q9UBI1) COMM domain-containing protein 4 × 1 (Q9H0A8) COMM domain-containing protein 5 × 1 (Q9GZQ3) COMM domain-containing protein 6 × 1 (Q7Z4G1) COMM domain-containing protein 7 × 1 (Q86VX2) COMM domain-containing protein 8 × 1 (Q9NX08) COMM domain-containing protein 10 × 1 (Q9Y6G5) Coiled-coil domain-containing protein 93 × 1 (Q567U6) Coiled-coil domain-containing protein 22 × 1 (O60826) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name COMD9_HUMAN
Isoform —
PDB entities 9
Chains and sequence ranges Author chain I; PDBConstruct 1–198; UniProt 1–198

COMM domain-containing protein 10

Homo sapiens

UniProt Q9Y6G5

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 COMM domain-containing protein 1 × 1 (Q8N668) COMM domain-containing protein 2 × 1 (Q86X83) COMM domain-containing protein 3 × 1 (Q9UBI1) COMM domain-containing protein 4 × 1 (Q9H0A8) COMM domain-containing protein 5 × 1 (Q9GZQ3) COMM domain-containing protein 6 × 1 (Q7Z4G1) COMM domain-containing protein 7 × 1 (Q86VX2) COMM domain-containing protein 8 × 1 (Q9NX08) COMM domain-containing protein 9 × 1 (Q9P000) Coiled-coil domain-containing protein 93 × 1 (Q567U6) Coiled-coil domain-containing protein 22 × 1 (O60826) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name COMDA_HUMAN
Isoform —
PDB entities 10
Chains and sequence ranges Author chain J; PDBConstruct 1–202; UniProt 1–202

Coiled-coil domain-containing protein 93

Homo sapiens

UniProt Q567U6

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 COMM domain-containing protein 1 × 1 (Q8N668) COMM domain-containing protein 2 × 1 (Q86X83) COMM domain-containing protein 3 × 1 (Q9UBI1) COMM domain-containing protein 4 × 1 (Q9H0A8) COMM domain-containing protein 5 × 1 (Q9GZQ3) COMM domain-containing protein 6 × 1 (Q7Z4G1) COMM domain-containing protein 7 × 1 (Q86VX2) COMM domain-containing protein 8 × 1 (Q9NX08) COMM domain-containing protein 9 × 1 (Q9P000) COMM domain-containing protein 10 × 1 (Q9Y6G5) Coiled-coil domain-containing protein 22 × 1 (O60826) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CCD93_HUMAN
Isoform —
PDB entities 11
Chains and sequence ranges Author chain N; PDBConstruct 1–631; UniProt 1–631

Coiled-coil domain-containing protein 22

Homo sapiens

UniProt O60826

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 COMM domain-containing protein 1 × 1 (Q8N668) COMM domain-containing protein 2 × 1 (Q86X83) COMM domain-containing protein 3 × 1 (Q9UBI1) COMM domain-containing protein 4 × 1 (Q9H0A8) COMM domain-containing protein 5 × 1 (Q9GZQ3) COMM domain-containing protein 6 × 1 (Q7Z4G1) COMM domain-containing protein 7 × 1 (Q86VX2) COMM domain-containing protein 8 × 1 (Q9NX08) COMM domain-containing protein 9 × 1 (Q9P000) COMM domain-containing protein 10 × 1 (Q9Y6G5) Coiled-coil domain-containing protein 93 × 1 (Q567U6) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CCD22_HUMAN
Isoform —
PDB entities 12
Chains and sequence ranges Author chain T; PDBConstruct 1–627; UniProt 1–627

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8f2u
Deposition date deposition_date2022-11-08
Structure title titleHuman CCC complex
Keywords keywordsendosomal sorting, commander, CCC complex, ENDOCYTOSIS; ENDOCYTOSIS
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8f2u__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8f2u__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8f2u__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)44.77 Å
Rg (electron density)44.00 Å
Total Rg44.39 Å
Atom count17684
Residues2236
Excluded volume316540 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8f2u__assembly_1__model_1 dodecameric (12) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (12)

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7. Citations (1)