Hemagglutinin HA1 chain
Influenza A virus
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Other combination Heteromer Protein × 9 其他Polymer 6 PDB declaration: nonameric（9） Consistent with protein copy count | Chain A； UniProt 27–344 Chain B； UniProt 27–344 Chain C； UniProt 27–344 | Not recorded | Hemagglutinin HA2 chain × 3 （P03437） Affimer molecule (A31) × 3 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 | ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE | Resolution 3.40 Å |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 8PK3 | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 3SDY Crystal Structure of Broadly Neutralizing Antibody CR8020 Bound to the Influenza A H3 Hemagglutinin Deposited 2011-06-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain A
27–345（319 aa）
Fragment：UNP residues 27-345
Chain B
346–521（176 aa）
Fragment：UNP residues 346-521
|
Not recorded | SO4 SULFATE ION × 30 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.4；298 K；1.8M ammonium sulfate, 100mM sodium acetate 5.4, and 50mM NaCl, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.85 Å R-free 0.235 |
| 4FNK Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin Deposited 2012-06-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Fragment：UNP residues 27-345
Chain B
346–519（174 aa）
Fragment：UNP residues 346-519
Chain C
27–345（319 aa）
Fragment：UNP residues 27-345
Chain D
346–519（174 aa）
Fragment：UNP residues 346-519
Chain E
27–345（319 aa）
Fragment：UNP residues 27-345
Chain F
346–519（174 aa）
Fragment：UNP residues 346-519
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 SO4 SULFATE ION × 6 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；2.0 M ammonium sulfate, 100 mM sodium cacodylate, pH 6.5, 200 mM sodium chloride, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 1.90 Å R-free 0.189 |
| 4FP8 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin, HA1 subunit Deposited 2012-06-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
59–325（267 aa）
Fragment：UNP residues 59-325
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；277 K；10% w/v PEG3000, 200 mM zinc acetate, 100 mM sodium acetate, pH 4.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.95 Å R-free 0.241 |
| 4FP8 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin, HA1 subunit Deposited 2012-06-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
59–325（267 aa）
Fragment：UNP residues 59-325
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；277 K；10% w/v PEG3000, 200 mM zinc acetate, 100 mM sodium acetate, pH 4.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.95 Å R-free 0.241 |
| 4FP8 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin, HA1 subunit Deposited 2012-06-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
59–325（267 aa）
Fragment：UNP residues 59-325
|
Not recorded | ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；277 K；10% w/v PEG3000, 200 mM zinc acetate, 100 mM sodium acetate, pH 4.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.95 Å R-free 0.241 |
| 4FP8 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin, HA1 subunit Deposited 2012-06-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain D
59–325（267 aa）
Fragment：UNP residues 59-325
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；277 K；10% w/v PEG3000, 200 mM zinc acetate, 100 mM sodium acetate, pH 4.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.95 Å R-free 0.241 |
| 4FQR Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin Deposited 2012-06-25 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain A
27–345（319 aa）
Fragment：UNP residues 27-345
Chain B
346–519（174 aa）
Fragment：UNP residues 346-519
Chain C
27–345（319 aa）
Fragment：UNP residues 27-345
Chain D
346–519（174 aa）
Fragment：UNP residues 346-519
Chain E
27–345（319 aa）
Fragment：UNP residues 27-345
Chain F
346–519（174 aa）
Fragment：UNP residues 346-519
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；28% w/v PEG400, 200 mM calcium chloride, 100 mM HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 4.10 Å R-free 0.334 |
| 4FQR Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin Deposited 2012-06-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain G
27–345（319 aa）
Fragment：UNP residues 27-345
Chain H
346–519（174 aa）
Fragment：UNP residues 346-519
Chain I
27–345（319 aa）
Fragment：UNP residues 27-345
Chain J
346–519（174 aa）
Fragment：UNP residues 346-519
Chain K
27–345（319 aa）
Fragment：UNP residues 27-345
Chain L
346–519（174 aa）
Fragment：UNP residues 346-519
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；28% w/v PEG400, 200 mM calcium chloride, 100 mM HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 4.10 Å R-free 0.334 |
| 4FQR Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin Deposited 2012-06-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain M
27–345（319 aa）
Fragment：UNP residues 27-345
Chain N
346–519（174 aa）
Fragment：UNP residues 346-519
Chain O
27–345（319 aa）
Fragment：UNP residues 27-345
Chain P
346–519（174 aa）
Fragment：UNP residues 346-519
Chain Q
27–345（319 aa）
Fragment：UNP residues 27-345
Chain R
346–519（174 aa）
Fragment：UNP residues 346-519
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；28% w/v PEG400, 200 mM calcium chloride, 100 mM HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 4.10 Å R-free 0.334 |
| 4FQR Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin Deposited 2012-06-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain S
27–345（319 aa）
Fragment：UNP residues 27-345
Chain T
346–519（174 aa）
Fragment：UNP residues 346-519
Chain U
27–345（319 aa）
Fragment：UNP residues 27-345
Chain V
346–519（174 aa）
Fragment：UNP residues 346-519
Chain W
27–345（319 aa）
Fragment：UNP residues 27-345
Chain X
346–519（174 aa）
Fragment：UNP residues 346-519
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；28% w/v PEG400, 200 mM calcium chloride, 100 mM HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 4.10 Å R-free 0.334 |
| 4FQY Crystal structure of broadly neutralizing antibody CR9114 bound to H3 influenza hemagglutinin Deposited 2012-06-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain A
27–345（319 aa）
Fragment：UNP residues 27-345
Chain B
346–519（174 aa）
Fragment：UNP residues 346-519
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；293 K；200 mM zinc acetate, 14% PEG1000, 100 mM sodium acetate, pH 4.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 5.25 Å R-free 0.374 |
| 4NM8 Crystal structure of broadly neutralizing antibody CR8043 bound to H3 influenza hemagglutinin Deposited 2013-11-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain A
27–345（319 aa）
Chain B
346–521（176 aa）
Chain C
27–345（319 aa）
Chain D
346–521（176 aa）
Chain E
27–345（319 aa）
Chain F
346–521（176 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；277 K；2.2 M ammonium sulfate, 0.1 M sodium acetate pH 5.5, 3% PEG 400, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 4.00 Å R-free 0.292 |
| 4UBD Crystal structure of a neutralizing human monoclonal antibody with 1968 H3 HA Deposited 2014-08-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain A
25–344（320 aa）
Chain B
346–520（175 aa）
Chain E
25–344（320 aa）
Chain F
346–520（175 aa）
Chain I
25–344（320 aa）
Chain J
346–520（175 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；20% PEG 3000, 100mM Na Citrate
|
Resolution 3.50 Å R-free 0.258 |
| 4UBD Crystal structure of a neutralizing human monoclonal antibody with 1968 H3 HA Deposited 2014-08-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain M
25–344（320 aa）
Chain N
346–520（175 aa）
Chain Q
25–344（320 aa）
Chain R
346–520（175 aa）
Chain U
25–344（320 aa）
Chain V
346–520（175 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；20% PEG 3000, 100mM Na Citrate
|
Resolution 3.50 Å R-free 0.258 |
| 4WE4 The crystal structure of hemagglutinin from 1968 H3N2 influenza virus Deposited 2014-09-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
25–345（321 aa）
Fragment：unp residues 25-345
Chain B
346–517（172 aa）
Fragment：unp residues 346-517
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 PEG DI(HYDROXYETHYL)ETHER × 21 PE5 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 7.9；293 K；0.1M Tris-HCl, 25% PEG1000
|
Resolution 2.35 Å R-free 0.236 |
| 4ZCJ Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin HA1 Cys30, HA2 Cys47 mutant Deposited 2015-04-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Fragment：HA1 chain (UNP residues 27-345)
Chain B
346–521（176 aa）
Fragment：HA2 chain (UNP residues 346-521)
Chain C
27–345（319 aa）
Fragment：HA1 chain (UNP residues 27-345)
Chain D
346–521（176 aa）
Fragment：HA2 chain (UNP residues 346-521)
Chain E
27–345（319 aa）
Fragment：HA1 chain (UNP residues 27-345)
Chain F
346–521（176 aa）
Fragment：HA2 chain (UNP residues 346-521)
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；8% PEG 8000, 0.1 M HEPES pH 7
|
Resolution 3.00 Å R-free 0.275 |
| 5K9K Crystal structure of multidonor HV6-1-class broadly neutralizing Influenza A antibody 56.a.09 in complex with Hemagglutinin Hong Kong 1968. Deposited 2016-05-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain I
17–519（503 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.28M ammonium citrate, pH 8.5, and 12.5% (w/v) PEG-8000
|
Resolution 2.97 Å R-free 0.265 |
| 5K9K Crystal structure of multidonor HV6-1-class broadly neutralizing Influenza A antibody 56.a.09 in complex with Hemagglutinin Hong Kong 1968. Deposited 2016-05-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain F
17–519（503 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.28M ammonium citrate, pH 8.5, and 12.5% (w/v) PEG-8000
|
Resolution 2.97 Å R-free 0.265 |
| 5K9Q Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.a.26 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin Deposited 2016-06-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain A
24–343（320 aa）
Chain B
348–517（170 aa）
Chain C
24–343（320 aa）
Chain D
348–517（170 aa）
Chain E
24–343（320 aa）
Chain F
348–517（170 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.01M L-cysteine, 0.09M sodium cacodylate, pH 6.5, 0.18M magnesium acetate, and 7.9% (w/v) PEG-8000
|
Resolution 2.50 Å R-free 0.218 |
| 5K9Q Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.a.26 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin Deposited 2016-06-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain M
24–343（320 aa）
Chain N
348–517（170 aa）
Chain O
24–343（320 aa）
Chain P
348–517（170 aa）
Chain Q
24–343（320 aa）
Chain R
348–517（170 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.01M L-cysteine, 0.09M sodium cacodylate, pH 6.5, 0.18M magnesium acetate, and 7.9% (w/v) PEG-8000
|
Resolution 2.50 Å R-free 0.218 |
| 5KAN Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.g.07 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin Deposited 2016-06-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain A
24–342（319 aa）
Chain B
349–521（173 aa）
Chain C
24–342（319 aa）
Chain D
349–521（173 aa）
Chain E
24–342（319 aa）
Chain F
349–521（173 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 17 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；0.010M Tris(2-carboxyethyl)phosphine HCl (TCEP) , 0.09 M 2-(N-morpholino)ethanesulfonic acid (MES), pH 6.0, 12% (w/v) PEG-6000
|
Resolution 2.79 Å R-free 0.243 |
| 5KUY Influenza hemagglutinin H3 A/Hong Kong/1/1968 in complex with designed inhibitor protein HSB.2A Deposited 2016-07-13 | Different construct Different mutation/modification Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric |
Chain A
27–345（319 aa）
Chain B
346–521（176 aa）
Chain C
27–345（319 aa）
Chain D
346–521（176 aa）
Chain E
27–345（319 aa）
Chain F
346–521（176 aa）
|
Mutation：R452G Mutation：R452G Mutation：R452G | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；10% PEG 6000, 100 mM MES pH 6.0
|
Resolution 2.60 Å R-free 0.204 |
| 5T6N Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin in complex with the antiviral drug arbidol Deposited 2016-09-01 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Chain C
27–345（319 aa）
Chain E
27–345（319 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 75U ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylsulfanyl)methyl]-1H-indole-3-carboxylate × 3 SO4 SULFATE ION × 4 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；2.0 M ammonium sulfate, 100 mM sodium cacodylate, 200 mM sodium chloride
|
Resolution 2.54 Å R-free 0.220 |
| 5THF Crystal structure of H3 hemagglutinin with insertion of two amino acids in the 150-loop from the A/Hong Kong/1/1968 (H3N2) influenza virus Deposited 2016-09-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Chain B
346–521（176 aa）
Chain C
27–345（319 aa）
Chain D
346–521（176 aa）
Chain E
27–345（319 aa）
Chain F
346–521（176 aa）
|
Mutation：Insertion Mutation：R468G Mutation：Insertion Mutation：R468G Mutation：Insertion Mutation：R468G | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293.15 K；20% (w/v) PEG 3500, 0.2M Na2HPO4 pH 9.1
|
Resolution 2.59 Å R-free 0.239 |
| 5UMN Crystal structure of C05 VPGSGW mutant bound to H3 influenza hemagglutinin, HA1 subunit Deposited 2017-01-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
59–325（267 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 1PE PENTAETHYLENE GLYCOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.1 M sodium citrate pH 5.5 and 9% PEG 8000
|
Resolution 1.97 Å R-free 0.208 |
| 5UMN Crystal structure of C05 VPGSGW mutant bound to H3 influenza hemagglutinin, HA1 subunit Deposited 2017-01-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
59–325（267 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 1PE PENTAETHYLENE GLYCOL × 3 NA SODIUM ION × 1 FLC CITRATE ANION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.1 M sodium citrate pH 5.5 and 9% PEG 8000
|
Resolution 1.97 Å R-free 0.208 |
| 5VTQ Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225L/L226S mutant in complex with 3'-SLN Deposited 2017-05-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
|
Mutation：G225L/L226S | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.95 Å R-free 0.228 |
| 5VTQ Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225L/L226S mutant in complex with 3'-SLN Deposited 2017-05-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
|
Mutation：G225L/L226S | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.95 Å R-free 0.228 |
| 5VTQ Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225L/L226S mutant in complex with 3'-SLN Deposited 2017-05-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Mutation：G225L/L226S | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.95 Å R-free 0.228 |
| 5VTQ Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225L/L226S mutant in complex with 3'-SLN Deposited 2017-05-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Mutation：G225L/L226S Mutation：G225L/L226S Mutation：G225L/L226S | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.95 Å R-free 0.228 |
| 5VTR Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225L/L226S mutant in complex with 6'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
|
Mutation：G225L/L226S | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.50 Å R-free 0.213 |
| 5VTR Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225L/L226S mutant in complex with 6'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
|
Mutation：G225L/L226S | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 SIA N-acetyl-alpha-neuraminic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.50 Å R-free 0.213 |
| 5VTR Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225L/L226S mutant in complex with 6'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Mutation：G225L/L226S | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 SIA N-acetyl-alpha-neuraminic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.50 Å R-free 0.213 |
| 5VTR Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225L/L226S mutant in complex with 6'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Mutation：G225L/L226S Mutation：G225L/L226S Mutation：G225L/L226S | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 SIA N-acetyl-alpha-neuraminic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.50 Å R-free 0.213 |
| 5VTU Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225L/L226S mutant apo form Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M potassium nitrate and 20% PEG 3350
|
Resolution 2.45 Å R-free 0.220 |
| 5VTU Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225L/L226S mutant apo form Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M potassium nitrate and 20% PEG 3350
|
Resolution 2.45 Å R-free 0.220 |
| 5VTU Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225L/L226S mutant apo form Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M potassium nitrate and 20% PEG 3350
|
Resolution 2.45 Å R-free 0.220 |
| 5VTU Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225L/L226S mutant apo form Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M potassium nitrate and 20% PEG 3350
|
Resolution 2.45 Å R-free 0.220 |
| 5VTV Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225M/L226T/S228A mutant in complex with 3'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
|
Mutation：G225M/L226T/S228A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.25 Å R-free 0.212 |
| 5VTV Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225M/L226T/S228A mutant in complex with 3'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
|
Mutation：G225M/L226T/S228A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.25 Å R-free 0.212 |
| 5VTV Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225M/L226T/S228A mutant in complex with 3'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Mutation：G225M/L226T/S228A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 TAM TRIS(HYDROXYETHYL)AMINOMETHANE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.25 Å R-free 0.212 |
| 5VTV Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225M/L226T/S228A mutant in complex with 3'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Mutation：G225M/L226T/S228A Mutation：G225M/L226T/S228A Mutation：G225M/L226T/S228A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 TAM TRIS(HYDROXYETHYL)AMINOMETHANE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.25 Å R-free 0.212 |
| 5VTW Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225M/L226T/S228A mutant in complex with 6'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
|
Mutation：G225M/L226T/S228A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 SIA N-acetyl-alpha-neuraminic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.35 Å R-free 0.213 |
| 5VTW Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225M/L226T/S228A mutant in complex with 6'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
|
Mutation：G225M/L226T/S228A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.35 Å R-free 0.213 |
| 5VTW Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225M/L226T/S228A mutant in complex with 6'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Mutation：G225M/L226T/S228A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 TAM TRIS(HYDROXYETHYL)AMINOMETHANE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.35 Å R-free 0.213 |
| 5VTW Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225M/L226T/S228A mutant in complex with 6'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Mutation：G225M/L226T/S228A Mutation：G225M/L226T/S228A Mutation：G225M/L226T/S228A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 SIA N-acetyl-alpha-neuraminic acid × 1 TAM TRIS(HYDROXYETHYL)AMINOMETHANE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.35 Å R-free 0.213 |
| 5VTX Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225M/L226T/S228A mutant apo form Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
|
Mutation：G225M/L226T/S228A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.65 Å R-free 0.217 |
| 5VTX Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225M/L226T/S228A mutant apo form Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
|
Mutation：G225M/L226T/S228A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.65 Å R-free 0.217 |
| 5VTX Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225M/L226T/S228A mutant apo form Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Mutation：G225M/L226T/S228A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.65 Å R-free 0.217 |
| 5VTX Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225M/L226T/S228A mutant apo form Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Mutation：G225M/L226T/S228A Mutation：G225M/L226T/S228A Mutation：G225M/L226T/S228A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.65 Å R-free 0.217 |
| 5VTY Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant in complex with 3'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
|
Mutation：G225Q/L226A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG
8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.36 Å R-free 0.210 |
| 5VTY Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant in complex with 3'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
|
Mutation：G225Q/L226A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG
8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.36 Å R-free 0.210 |
| 5VTY Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant in complex with 3'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Mutation：G225Q/L226A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG
8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.36 Å R-free 0.210 |
| 5VTY Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant in complex with 3'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Mutation：G225Q/L226A Mutation：G225Q/L226A Mutation：G225Q/L226A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG
8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.36 Å R-free 0.210 |
| 5VTZ Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant apo form Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
|
Mutation：G225Q/L226A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG
8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.15 Å R-free 0.199 |
| 5VTZ Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant apo form Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
|
Mutation：G225Q/L226A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG
8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.15 Å R-free 0.199 |
| 5VTZ Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant apo form Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Mutation：G225Q/L226A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG
8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.15 Å R-free 0.199 |
| 5VTZ Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant apo form Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Mutation：G225Q/L226A Mutation：G225Q/L226A Mutation：G225Q/L226A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG
8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.15 Å R-free 0.199 |
| 5VU4 Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant in complex with 6'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG
8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.25 Å R-free 0.208 |
| 5VU4 Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant in complex with 6'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 SIA N-acetyl-alpha-neuraminic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG
8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.25 Å R-free 0.208 |
| 5VU4 Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant in complex with 6'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 SIA N-acetyl-alpha-neuraminic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG
8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.25 Å R-free 0.208 |
| 5VU4 Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant in complex with 6'-SLN Deposited 2017-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 SIA N-acetyl-alpha-neuraminic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG
8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.25 Å R-free 0.208 |
| 6BKM Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin E190D mutant apo form Deposited 2017-11-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
27–345（319 aa）
Chain C
27–345（319 aa）
Chain E
27–345（319 aa）
|
Mutation：E190D Mutation：E190D Mutation：E190D | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 TAM TRIS(HYDROXYETHYL)AMINOMETHANE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 6% PEG 8000, and 39% 2-methyl-2,4-pentanediol
|
Resolution 2.20 Å R-free 0.209 |
| 6BKM Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin E190D mutant apo form Deposited 2017-11-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Chain C
27–345（319 aa）
Chain E
27–345（319 aa）
|
Mutation：E190D Mutation：E190D Mutation：E190D | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 TAM TRIS(HYDROXYETHYL)AMINOMETHANE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 6% PEG 8000, and 39% 2-methyl-2,4-pentanediol
|
Resolution 2.20 Å R-free 0.209 |
| 6BKQ Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin E190D mutant in complex with 6'-SLN Deposited 2017-11-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
27–345（319 aa）
Chain C
27–345（319 aa）
Chain E
27–345（319 aa）
|
Mutation：E190D Mutation：E190D Mutation：E190D | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 TAM TRIS(HYDROXYETHYL)AMINOMETHANE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 6% PEG 8000, and 39% 2-methyl-2,4-pentanediol
|
Resolution 2.25 Å R-free 0.208 |
| 6BKQ Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin E190D mutant in complex with 6'-SLN Deposited 2017-11-09 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain B
346–519（174 aa）
Chain D
346–519（174 aa）
Chain F
346–519（174 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 6% PEG 8000, and 39% 2-methyl-2,4-pentanediol
|
Resolution 2.25 Å R-free 0.208 |
| 6BKQ Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin E190D mutant in complex with 6'-SLN Deposited 2017-11-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Chain B
346–519（174 aa）
Chain C
27–345（319 aa）
Chain D
346–519（174 aa）
Chain E
27–345（319 aa）
Chain F
346–519（174 aa）
|
Mutation：E190D Mutation：E190D Mutation：E190D | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 TAM TRIS(HYDROXYETHYL)AMINOMETHANE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 6% PEG 8000, and 39% 2-methyl-2,4-pentanediol
|
Resolution 2.25 Å R-free 0.208 |
| 6CEX Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin in complex with small molecule N-Cyclohexyltaurine Deposited 2018-02-12 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Chain C
27–345（319 aa）
Chain E
27–345（319 aa）
|
Not recorded | NHE 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID × 6 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 SO4 SULFATE ION × 6 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；2.0 M ammonium sulfate, 100 mM sodium cacodylate, 200 mM sodium chloride, pH 6.5, 20 degree
|
Resolution 2.57 Å R-free 0.204 |
| 6D0U Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit Deposited 2018-04-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
59–325（267 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.1 M sodium citrate pH 5.5 and 20% PEG 3000
|
Resolution 3.25 Å R-free 0.268 |
| 6D0U Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit Deposited 2018-04-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
59–325（267 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.1 M sodium citrate pH 5.5 and 20% PEG 3000
|
Resolution 3.25 Å R-free 0.268 |
| 6D0U Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit Deposited 2018-04-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain J
59–325（267 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.1 M sodium citrate pH 5.5 and 20% PEG 3000
|
Resolution 3.25 Å R-free 0.268 |
| 6D0U Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit Deposited 2018-04-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain G
59–325（267 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.1 M sodium citrate pH 5.5 and 20% PEG 3000
|
Resolution 3.25 Å R-free 0.268 |
| 6NHP Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin HA2 I45T mutant Deposited 2018-12-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain B
346–521（176 aa）
Fragment：residues 346-521
Chain D
346–521（176 aa）
Fragment：residues 346-521
Chain F
346–521（176 aa）
Fragment：residues 346-521
|
Mutation：I45T Mutation：I45T Mutation：I45T | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.25 Å R-free 0.208 |
| 6NHQ Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin HA2 I45M mutant Deposited 2018-12-23 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Fragment：residues 27-345
Chain B
346–521（176 aa）
Fragment：residues 346-521
Chain C
27–345（319 aa）
Fragment：residues 27-345
Chain D
346–521（176 aa）
Fragment：residues 346-521
Chain E
27–345（319 aa）
Fragment：residues 27-345
Chain F
346–521（176 aa）
Fragment：residues 346-521
|
Mutation：I45M Mutation：I45M Mutation：I45M | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.50 Å R-free 0.219 |
| 6NHR Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin HA2 I45F mutant Deposited 2018-12-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain B
346–521（176 aa）
Fragment：residues 346-521
Chain D
346–521（176 aa）
Fragment：residues 346-521
Chain F
346–521（176 aa）
Fragment：residues 346-521
|
Mutation：I45F Mutation：I45F Mutation：I45F | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 38% 2-methyl-2,4-pentanediol
|
Resolution 2.10 Å R-free 0.216 |
| 6NZ7 Crystal structure of broadly neutralizing Influenza A antibody 429 B01 in complex with Hemagglutinin Hong Kong 1968 Deposited 2019-02-13 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
24–342（319 aa）
Fragment：residues 24-342
Chain B
349–521（173 aa）
Fragment：residues 349-521
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；300 K；10 % PEG8000 (w/v), 100 mM Tris/Cl, pH 8.5 and 7.5 % 1,6-hexanediol (w/v)
|
Resolution 2.95 Å R-free 0.267 |
| 6NZ7 Crystal structure of broadly neutralizing Influenza A antibody 429 B01 in complex with Hemagglutinin Hong Kong 1968 Deposited 2019-02-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
24–342（319 aa）
Fragment：residues 24-342
Chain F
349–521（173 aa）
Fragment：residues 349-521
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；300 K；10 % PEG8000 (w/v), 100 mM Tris/Cl, pH 8.5 and 7.5 % 1,6-hexanediol (w/v)
|
Resolution 2.95 Å R-free 0.267 |
| 6OCB Crystal structure of FluA-20 Fab in complex with the head domain of H3 (A/Hong Kong/1/1968) Deposited 2019-03-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
59–325（267 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277.15 K；0.1 M Tris-HCl pH 8.5
0.2 M lithium sulfate
40% (v/v) PEG400
|
Resolution 2.10 Å R-free 0.239 |
| 6TZB Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin in complex with 6'-SLNLN Deposited 2019-08-12 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
27–345（319 aa）
Fragment：residues 27-345
Chain C
27–345（319 aa）
Fragment：residues 27-345
Chain E
27–345（319 aa）
Fragment：residues 27-345
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate pH 6.5, 6% PEG 8000, and 39% 2-methyl-2,4-pentanediol
|
Resolution 2.24 Å R-free 0.207 |
| 6WXB Cryo-EM Structure of Influenza Hemagglutinin (HA) Trimer Vitrified Using Back-it-up Deposited 2020-05-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
17–527（511 aa）
Chain B
17–527（511 aa）
Chain C
17–527（511 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 BMA beta-D-mannopyranose × 3 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE；Back-it-up (ultrasonic specimen application and through-grid wicking in a high-speed specimen preparation device) was used
|
Resolution 2.90 Å |
| 7K37 Structure of full-length influenza HA with a head-binding antibody at pH 7.8 Deposited 2020-09-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain A
1–345（345 aa）
Chain C
1–345（345 aa）
Chain E
1–345（345 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 7K39 Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation A, neutral pH-like Deposited 2020-09-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain A
1–345（345 aa）
Chain C
1–345（345 aa）
Chain E
1–345（345 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 5.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 7K3A Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation B, fusion peptide release Deposited 2020-09-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain A
1–345（345 aa）
Chain C
1–345（345 aa）
Chain E
1–345（345 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 5.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.20 Å |
| 7K3B Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation C, central helices splay Deposited 2020-09-10 | Different construct Different oligomeric state Different experimental conditions | Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain A
1–345（345 aa）
Chain C
1–345（345 aa）
Chain E
1–345（345 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 5.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 7QA4 Crystal structure of stabilized H3N2 A/Hong Kong/1/1968 Hemagglutinin at 2.2 Angstrom Deposited 2021-11-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
17–521（505 aa）
Fragment：Hemagglutinin
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 NO3 NITRATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；20.00 %w/v PEG 3350, 0.2 M LiNO3
|
Resolution 2.19 Å R-free 0.251 |
| 7RDH Crystal structure of the de novo designed binding protein H3mb in complex with the 1968 influenza A virus hemagglutinin Deposited 2021-07-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
27–345（319 aa）
Chain B
346–521（176 aa）
Chain C
27–345（319 aa）
Chain D
346–521（176 aa）
Chain E
27–345（319 aa）
Chain F
346–521（176 aa）
|
Mutation：R123G Mutation：R123G Mutation：R123G | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277.15 K；0.2M sodium thiocyanate and 20% (w/v) polyethylene glycol 3350 as a precipitant
|
Resolution 2.75 Å R-free 0.289 |
| 7VDF 2.56 A structure of influenza hemagglutinin (HA) trimer Deposited 2021-09-06 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
17–527（511 aa）
Chain B
17–527（511 aa）
Chain C
17–527（511 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 BMA beta-D-mannopyranose × 3 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.56 Å |
| 7X6L Cryo-EM structure of H3 hemagglutinin from A/HongKong/01/1968 in complex with a neutralizing antibody 28-12 Deposited 2022-03-07 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain A
17–345（329 aa）
Chain C
17–345（329 aa）
Chain D
17–345（329 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.70 Å |
| 9CXT Hemagglutinin A/Hong Kong/1/68 produced in GnTI- cells Deposited 2024-07-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
17–344（328 aa）
Chain B
345–524（180 aa）
Chain C
17–344（328 aa）
Chain D
345–524（180 aa）
Chain E
17–344（328 aa）
Chain F
345–524（180 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；TBS
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 9CXU Endo H-treated hemagglutinin A/Hong Kong/1/68 Deposited 2024-07-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
17–344（328 aa）
Chain B
345–524（180 aa）
Chain C
17–344（328 aa）
Chain D
345–524（180 aa）
Chain E
17–344（328 aa）
Chain F
345–524（180 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；TBS
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.30 Å |
46 other PDB entries and 90 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | HEMA_I68A4 |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 5–322； UniProt 27–344 Author chain B； PDBConstruct 5–322； UniProt 27–344 Author chain C； PDBConstruct 5–322； UniProt 27–344 |
