8pr3

Cytoplasmic dynein-1 heavy chain bound to JIP3-RH1

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

C-Jun-amino-terminal kinase-interacting protein 3

Homo sapiens

UniProt Q9UPT6

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 Cytoplasmic dynein 1 heavy chain 1 × 2 (Q14204) Cytoplasmic dynein 1 intermediate chain 2 × 2 (Q13409) Cytoplasmic dynein 1 light intermediate chain 2 × 3 (O43237) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name JIP3_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain B; PDBConstruct 8–567; UniProt 1–560 Author chain C; PDBConstruct 8–567; UniProt 1–560

Cytoplasmic dynein 1 heavy chain 1

Homo sapiens

UniProt Q14204

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 C-Jun-amino-terminal kinase-interacting protein 3 × 2 (Q9UPT6) Cytoplasmic dynein 1 intermediate chain 2 × 2 (Q13409) Cytoplasmic dynein 1 light intermediate chain 2 × 3 (O43237) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name DYHC1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain f; PDBConstruct 1–4646; UniProt 1–4646 Author chain m; PDBConstruct 1–4646; UniProt 1–4646

Cytoplasmic dynein 1 intermediate chain 2

Homo sapiens

UniProt Q13409

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 C-Jun-amino-terminal kinase-interacting protein 3 × 2 (Q9UPT6) Cytoplasmic dynein 1 heavy chain 1 × 2 (Q14204) Cytoplasmic dynein 1 light intermediate chain 2 × 3 (O43237) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name DC1I2_HUMAN
Isoform Q13409-3
PDB entities 3
Chains and sequence ranges Author chain h; PDBConstruct 1–612; UniProt 1–612 Author chain o; PDBConstruct 1–612; UniProt 1–612

Cytoplasmic dynein 1 light intermediate chain 2

Homo sapiens

UniProt O43237

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 C-Jun-amino-terminal kinase-interacting protein 3 × 2 (Q9UPT6) Cytoplasmic dynein 1 heavy chain 1 × 2 (Q14204) Cytoplasmic dynein 1 intermediate chain 2 × 2 (Q13409) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name DC1L2_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain E; PDBConstruct 1–492; UniProt 1–492 Author chain F; PDBConstruct 1–492; UniProt 1–492 Author chain j; PDBConstruct 1–492; UniProt 1–492

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8pr3
Deposition date deposition_date2023-07-12
Structure title titleCytoplasmic dynein-1 heavy chain bound to JIP3-RH1
Keywords keywordsDynein, AAA-Atpase, JIP3, MOTOR PROTEIN; MOTOR PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8pr3__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8pr3__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8pr3__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)50.13 Å
Rg (electron density)50.29 Å
Total Rg50.40 Å
Atom count17888
Residues2221
Excluded volume317410 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8pr3__assembly_1__model_1 nonameric (9) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)