9c79

Human monoclonal antibody MAD21-101 bound to the N-terminus of cleaved circumsporozoite protein

Method: X-RAY DIFFRACTION D_max: 89.4 Å Quality: GOOD

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Circumsporozoite protein

OrganismNot specified

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Other combination Heteromer Protein × 3 其他Polymer 1 PDB declaration: trimeric（3） Consistent with protein copy count	Chain D； UniProt 96–113	Non-standard monomer：Yes (specific site not provided by mmCIF)	Monoclonal antibody MAD21-101 Fab Heavy Chain × 1 Monoclonal antibody MAD21-101 Fab Light Chain × 1 alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 EDO 1,2-ETHANEDIOL × 8	X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；2.0 M ammonium sulfate, 0.2 M sodium chloride, 0.1 M cacodylate	Resolution 1.46 Å R-free 0.200

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB	Difference from Current Entry 9C79	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
3VDJ Crystal structure of circumsporozoite protein aTSR domain, R32 native form Deposited 2012-01-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4；295 K；0.1 M citrate, pH 4.0, 1 M lithium chloride, 20% PEG6000, VAPOR DIFFUSION, HANGING DROP, temperature 295K	Resolution 1.70 Å R-free 0.200
3VDJ Crystal structure of circumsporozoite protein aTSR domain, R32 native form Deposited 2012-01-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric	Chain A 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4；295 K；0.1 M citrate, pH 4.0, 1 M lithium chloride, 20% PEG6000, VAPOR DIFFUSION, HANGING DROP, temperature 295K	Resolution 1.70 Å R-free 0.200
3VDK Crystal structure of circumsporozoite protein aTSR domain, R32 platinum-bound form Deposited 2012-01-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)	Not recorded	PT PLATINUM (II) ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4；295 K；0.1 M citrate, pH 4.0, 1 M lithium chloride, 20% PEG6000, VAPOR DIFFUSION, HANGING DROP, temperature 295K	Resolution 1.85 Å R-free 0.217
3VDK Crystal structure of circumsporozoite protein aTSR domain, R32 platinum-bound form Deposited 2012-01-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric	Chain A 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)	Not recorded	PT PLATINUM (II) ION × 3	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4；295 K；0.1 M citrate, pH 4.0, 1 M lithium chloride, 20% PEG6000, VAPOR DIFFUSION, HANGING DROP, temperature 295K	Resolution 1.85 Å R-free 0.217
3VDL Crystal structure of circumsporozoite protein aTSR domain, P43212 form Deposited 2012-01-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.1；295 K；1.4 M sodium citrate, pH 6.1, VAPOR DIFFUSION, HANGING DROP, temperature 295K	Resolution 2.04 Å R-free 0.240
3VDL Crystal structure of circumsporozoite protein aTSR domain, P43212 form Deposited 2012-01-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.1；295 K；1.4 M sodium citrate, pH 6.1, VAPOR DIFFUSION, HANGING DROP, temperature 295K	Resolution 2.04 Å R-free 0.240
3VDL Crystal structure of circumsporozoite protein aTSR domain, P43212 form Deposited 2012-01-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain C 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.1；295 K；1.4 M sodium citrate, pH 6.1, VAPOR DIFFUSION, HANGING DROP, temperature 295K	Resolution 2.04 Å R-free 0.240
3VDL Crystal structure of circumsporozoite protein aTSR domain, P43212 form Deposited 2012-01-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 4 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric	Chain A 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374) Chain B 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374) Chain C 310–374（65 aa） Fragment：alpha-TSR domain (UNP residues 310-374)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.1；295 K；1.4 M sodium citrate, pH 6.1, VAPOR DIFFUSION, HANGING DROP, temperature 295K	Resolution 2.04 Å R-free 0.240
7RXI Fab234 in complex with the C-terminal alpha-TSR domain of P. falciparum Deposited 2021-08-23	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain A 310–375（66 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 310-375)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；20% PEG8000, 0.1 M HEPES, pH 7.5	Resolution 2.15 Å R-free 0.265
7RXJ Fab236 in complex with the C-terminal alpha-TSR domain of P. falciparum Deposited 2021-08-23	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain G 310–375（66 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 310-375)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.6；293.15 K；30% PEG2000 MME, 0.2 M ammonium sulfate, 0.1 M acetate, pH 4.6	Resolution 2.35 Å R-free 0.249
7RXJ Fab236 in complex with the C-terminal alpha-TSR domain of P. falciparum Deposited 2021-08-23	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain I 310–375（66 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 310-375)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.6；293.15 K；30% PEG2000 MME, 0.2 M ammonium sulfate, 0.1 M acetate, pH 4.6	Resolution 2.35 Å R-free 0.249
7RXL Fab1488 in complex with the C-terminal alpha-TSR domain of P. falciparum Deposited 2021-08-23	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain E 310–375（66 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 310-375)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.9；293.15 K；20% PEG3350, 0.2 M potassium chloride, pH 6.9	Resolution 1.82 Å R-free 0.255
7RXL Fab1488 in complex with the C-terminal alpha-TSR domain of P. falciparum Deposited 2021-08-23	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain F 310–375（66 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 310-375)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.9；293.15 K；20% PEG3350, 0.2 M potassium chloride, pH 6.9	Resolution 1.82 Å R-free 0.255
7RXP Fab1512 in complex with the C-terminal alpha-TSR domain of P. falciparum Deposited 2021-08-23	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain A 309–375（67 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 309-375)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；20% PEG3000, 0.2 M sodium chloride, 0.1 M HEPES. pH 7.5	Resolution 1.76 Å R-free 0.205
7S0X Fab352 in complex with the C-terminal alphaTSR domain of P. falciparum Deposited 2021-08-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain E 310–375（66 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 310-375)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.6；293.15 K；20% isopropanol, 20% PEG4000, 0.1 M sodium citrate, pH 5.6	Resolution 2.80 Å R-free 0.276
7S0X Fab352 in complex with the C-terminal alphaTSR domain of P. falciparum Deposited 2021-08-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain F 310–375（66 aa） Fragment：C-terminal alpha-TSR domain (UNP residues 310-375)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.6；293.15 K；20% isopropanol, 20% PEG4000, 0.1 M sodium citrate, pH 5.6	Resolution 2.80 Å R-free 0.276
7V05 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Deposited 2022-05-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain X 20–384（365 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE	Resolution 3.40 Å
8EK1 Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(dominant class) Deposited 2022-09-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric	Chain P 21–375（355 aa）	Mutation：C-79S, K-38S, K-37S, R-34A	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.60 Å
8EKA Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(class 2) Deposited 2022-09-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric	Chain P 21–375（355 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
8FG0 Crystal structure of the 3764 Fab in complex with the C-terminal PfCSP linker, PfCSP281-294. Deposited 2022-12-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain P 281–294（14 aa） Fragment：residues 281-294	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；19% (v/v) isopropanol, 19% (w/v) PEG 4000, 5% (v/v) glycerol, 0.095 M sodium citrate, pH 5.6	Resolution 2.36 Å R-free 0.237
8FG0 Crystal structure of the 3764 Fab in complex with the C-terminal PfCSP linker, PfCSP281-294. Deposited 2022-12-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain Q 281–294（14 aa） Fragment：residues 281-294	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；19% (v/v) isopropanol, 19% (w/v) PEG 4000, 5% (v/v) glycerol, 0.095 M sodium citrate, pH 5.6	Resolution 2.36 Å R-free 0.237
9C7D Human monoclonal antibody MAD22-38 bound to the N-terminus of cleaved circumsporozoite protein Deposited 2024-06-10	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric	Chain B 96–113（18 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；20% PEG 3350, 0.2 M ammonium chloride	Resolution 1.99 Å R-free 0.232
9C7F Human monoclonal antibody MAD24-01 bound to the N-terminus of cleaved circumsporozoite protein Deposited 2024-06-10	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric	Chain J 96–113（18 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；20% PEG 3350 and 0.2 M potassium fluoride	Resolution 1.82 Å R-free 0.238
9C7F Human monoclonal antibody MAD24-01 bound to the N-terminus of cleaved circumsporozoite protein Deposited 2024-06-10	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Other combination Heteromer；Protein × 3 PDB declaration: trimeric	Chain G 96–113（18 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；20% PEG 3350 and 0.2 M potassium fluoride	Resolution 1.82 Å R-free 0.238
9C7F Human monoclonal antibody MAD24-01 bound to the N-terminus of cleaved circumsporozoite protein Deposited 2024-06-10	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 3 Other combination Heteromer；Protein × 3 PDB declaration: trimeric	Chain I 96–113（18 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；20% PEG 3350 and 0.2 M potassium fluoride	Resolution 1.82 Å R-free 0.238
9C7F Human monoclonal antibody MAD24-01 bound to the N-terminus of cleaved circumsporozoite protein Deposited 2024-06-10	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 4 Other combination Heteromer；Protein × 3 PDB declaration: trimeric	Chain Q 96–113（18 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；20% PEG 3350 and 0.2 M potassium fluoride	Resolution 1.82 Å R-free 0.238
9CCA Cryo-EM structure of a designed pyridoxal phosphate (PLP) synthase fused to a designed circumsporozoite protein antigen from Plasmodium falciparum (CSP-P1-CSP and CSP-P2-CSP) Deposited 2024-06-21	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 24 PDB declaration: 24-meric	Chain A 101–114（14 aa） Chain A 131–150（20 aa） Chain A 310–383（74 aa） Chain B 101–114（14 aa） Chain B 131–150（20 aa） Chain B 310–383（74 aa） Chain C 101–114（14 aa） Chain C 131–150（20 aa） Chain C 310–383（74 aa） Chain D 101–114（14 aa） Chain D 131–150（20 aa） Chain D 310–383（74 aa） Chain E 101–114（14 aa） Chain E 131–150（20 aa） Chain E 310–383（74 aa） Chain F 101–114（14 aa） Chain F 131–150（20 aa） Chain F 310–383（74 aa） Chain G 101–114（14 aa） Chain G 131–150（20 aa） Chain G 310–383（74 aa） Chain H 101–114（14 aa） Chain H 131–150（20 aa） Chain H 310–383（74 aa） Chain I 101–114（14 aa） Chain I 131–150（20 aa） Chain I 310–383（74 aa） Chain J 101–114（14 aa） Chain J 131–150（20 aa） Chain J 310–383（74 aa） Chain K 101–114（14 aa） Chain K 131–150（20 aa） Chain K 310–383（74 aa） Chain L 101–114（14 aa） Chain L 131–150（20 aa） Chain L 310–383（74 aa） Chain M 101–114（14 aa） Chain M 131–150（20 aa） Chain M 310–383（74 aa） Chain N 101–114（14 aa） Chain N 131–150（20 aa） Chain N 310–383（74 aa） Chain O 101–114（14 aa） Chain O 131–150（20 aa） Chain O 310–383（74 aa） Chain P 101–114（14 aa） Chain P 131–150（20 aa） Chain P 310–383（74 aa） Chain Q 101–114（14 aa） Chain Q 131–150（20 aa） Chain Q 310–383（74 aa） Chain R 101–114（14 aa） Chain R 131–150（20 aa） Chain R 310–383（74 aa） Chain S 101–114（14 aa） Chain S 131–150（20 aa） Chain S 310–383（74 aa） Chain T 101–114（14 aa） Chain T 131–150（20 aa） Chain T 310–383（74 aa） Chain U 101–114（14 aa） Chain U 131–150（20 aa） Chain U 310–383（74 aa） Chain V 101–114（14 aa） Chain V 131–150（20 aa） Chain V 310–383（74 aa） Chain W 101–114（14 aa） Chain W 131–150（20 aa） Chain W 310–383（74 aa） Chain X 101–114（14 aa） Chain X 131–150（20 aa） Chain X 310–383（74 aa）	Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：K198R,K289C,S293C in Pdx1 (Uniprot numbering: K83R,K174C,S178C) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N) Mutation：N179Q,N242Q,H310N in Pdx2 (Uniprot numbering: N65Q,N128Q,H196N)	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.95 Å
9DSR Crystal structure of Fab MS-1805 in complex with NPNA3 peptide from circumsporozoite protein Deposited 2024-09-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain C 131–142（12 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M Zinc acetate, 20% (w/v) polyethylene glycol	Resolution 2.25 Å R-free 0.239
9DSS Crystal structure of Fab 7088 in complex with NPNA3 peptide from circumsporozoite protein Deposited 2024-09-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain A 131–142（12 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.2 M sodium chloride and 20% (w/v) polyethylene glycol 3350	Resolution 2.00 Å R-free 0.263
9DST Crystal structure of Fab MS-1805 in complex with N-terminal junction peptide from circumsporozoite protein Deposited 2024-09-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain A 95–110（16 aa）	Not recorded	CIT CITRIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.1 M sodium citrate, 20% (v/v) 2-propanol and 20% (w/v) polyethylene glycol 4000	Resolution 1.74 Å R-free 0.228
9DSU Crystal structure of Fab 7088 in complex with N-terminal junction peptide from circumsporozoite protein Deposited 2024-09-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain A 95–110（16 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293.15 K；0.1 M Tris pH 8.0, 1M lithium chloride and 10% (w/v) polyethylene glycol 6000	Resolution 3.14 Å R-free 0.275
9NCY Fab1392 in complex with the C-terminal alpha-TSR domain of the P. falciparum circumsporozoite protein Deposited 2025-02-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain A 310–376（67 aa）	Not recorded	PEG DI(HYDROXYETHYL)ETHER × 5 GOL GLYCEROL × 8 SO4 SULFATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；30% PEG-600, 10% (v/v) glycerol, 0.5 M NH4-sulfate, 0.1 M Tris pH 7.0, final pH 5.6.	Resolution 1.63 Å R-free 0.194
9NKZ Crystal structure of Fab MAM01 in complex with NANP6 peptide from circumsporozoite protein Deposited 2025-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain A 129–152（24 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.04 M potassium dihydrogen phosphate, 20% (v/v) glycerol and 16% (w/v) polyethylene glycol 8000	Resolution 1.48 Å R-free 0.210
9NL0 Crystal structure of Fab MAM01 in complex with NPNA3 peptide from circumsporozoite protein Deposited 2025-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain A 131–142（12 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.1 M Bicine pH 9.0 and 65% (v/v) 2-methyl-2,4-pentanediol	Resolution 1.54 Å R-free 0.202
9NL1 Crystal structure of Fab MAM01 in complex with junctional region peptide from circumsporozoite protein Deposited 2025-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain A 101–114（14 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.085 M Tris pH 8.5, 0.17 M sodium acetate, 15% (v/v) glycerol and 25.5 % (w/v) polyethylene glycol 4000	Resolution 2.71 Å R-free 0.313
9NZF Crystal structure of Fab MAM01 in complex with minor repeat region peptide from circumsporozoite protein Deposited 2025-03-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain A 109–128（20 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.2 M potassium acetate, pH 7.8 and 20% (w/v) polyethylene glycol 3350	Resolution 1.84 Å R-free 0.230
9ZM7 Crystal structure of Fab 7160 in complex with junctional region from circumsporozoite protein Deposited 2025-12-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain K 101–116（16 aa） Chain L 101–116（16 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.2 M sodium dihydrogen phosphate (pH 4.5) and 20% (w/v) polyethylene glycol (PEG) 3350	Resolution 2.30 Å R-free 0.275
9ZM7 Crystal structure of Fab 7160 in complex with junctional region from circumsporozoite protein Deposited 2025-12-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain C 101–116（16 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.2 M sodium dihydrogen phosphate (pH 4.5) and 20% (w/v) polyethylene glycol (PEG) 3350	Resolution 2.30 Å R-free 0.275
9ZM7 Crystal structure of Fab 7160 in complex with junctional region from circumsporozoite protein Deposited 2025-12-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain F 101–116（16 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.2 M sodium dihydrogen phosphate (pH 4.5) and 20% (w/v) polyethylene glycol (PEG) 3350	Resolution 2.30 Å R-free 0.275
9ZM7 Crystal structure of Fab 7160 in complex with junctional region from circumsporozoite protein Deposited 2025-12-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 5 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain O 101–116（16 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.2 M sodium dihydrogen phosphate (pH 4.5) and 20% (w/v) polyethylene glycol (PEG) 3350	Resolution 2.30 Å R-free 0.275
9ZM7 Crystal structure of Fab 7160 in complex with junctional region from circumsporozoite protein Deposited 2025-12-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 6 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain R 101–116（16 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.2 M sodium dihydrogen phosphate (pH 4.5) and 20% (w/v) polyethylene glycol (PEG) 3350	Resolution 2.30 Å R-free 0.275
9ZM7 Crystal structure of Fab 7160 in complex with junctional region from circumsporozoite protein Deposited 2025-12-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 7 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain U 101–116（16 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.2 M sodium dihydrogen phosphate (pH 4.5) and 20% (w/v) polyethylene glycol (PEG) 3350	Resolution 2.30 Å R-free 0.275
9ZM7 Crystal structure of Fab 7160 in complex with junctional region from circumsporozoite protein Deposited 2025-12-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 8 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain X 101–116（16 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.2 M sodium dihydrogen phosphate (pH 4.5) and 20% (w/v) polyethylene glycol (PEG) 3350	Resolution 2.30 Å R-free 0.275
9ZM8 Crystal structure of 7160 in complex with minor repeat region from circumsporozoite protein Deposited 2025-12-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric	Chain C 109–128（20 aa） Chain D 109–128（20 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M HEPES (pH 7.0), 1 M lithium chloride, and 20% (w/v) PEG 6000.	Resolution 2.27 Å R-free 0.286
9ZM9 Crystal structure of Fab 7160 in complex with short major repeat region (NPNA3) from circumsporozoite protein Deposited 2025-12-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric	Chain E 131–142（12 aa） Chain F 131–142（12 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.2 M sodium acetate (pH 7.0) and 20% (w/v) PEG 3350.	Resolution 1.88 Å R-free 0.245
9ZMA Crystal structure of Fab 7160 in complex with major repeat region (NANP6)from circumsporozoite protein Deposited 2025-12-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain I 129–152（24 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M magnesium nitrate (pH 5.8) and 20% (w/v) PEG 3350.	Resolution 2.33 Å R-free 0.236
9ZMA Crystal structure of Fab 7160 in complex with major repeat region (NANP6)from circumsporozoite protein Deposited 2025-12-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain J 129–152（24 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M magnesium nitrate (pH 5.8) and 20% (w/v) PEG 3350.	Resolution 2.33 Å R-free 0.236
9ZMB Crystal structure of Fab 7118 in complex with minor repeat region from circumsporozoite protein Deposited 2025-12-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain B 109–128（20 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M HEPES (pH 7.5), 30% (v/v) 1,2-propanediol, and 20% (v/v) PEG 400	Resolution 2.09 Å R-free 0.243
9ZMC Crystal structure of Fab 7118 in complex with major repeat region (NANP6) from circumsporozoite protein Deposited 2025-12-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain A 129–152（24 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M sodium cacodylate (pH 6.5), 0.16 M calcium acetate, 14.4% (w/v) PEG 8000, and 20% (v/v) glycerol	Resolution 2.00 Å R-free 0.217

30 other PDB entries and 49 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	CSP_PLAF7
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain D； PDBConstruct 1–18； UniProt 96–113

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

Download Download SAXS (.dat) P(r) (.pr.out) CIF

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	9c79
Deposition date deposition_date	2024-06-10
Structure title title	Human monoclonal antibody MAD21-101 bound to the N-terminus of cleaved circumsporozoite protein
Keywords keywords	Antibody, malaria, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method method	X-RAY DIFFRACTION

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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier	25.94 Å
Radius of gyration Rg (electron density) rg_electron	24.92 Å
Forward intensity I(0) i0	43435100.00
Molecular weight molecular_weight	50499.0 kDa
Excluded volume excluded_volume	62847 Å³
Envelope volume envelope_volume	77174 Å³
Hydration-shell volume shell_volume	26191 Å³
Envelope diameter envelope_diameter	94.2 Å
Shell Rg shell_rg	31.88 Å
Envelope Rg envelope_rg	24.90 Å
Shape Rg shape_rg	24.82 Å
Total Rg total_rg	25.99 Å
Total atoms total_atoms	6998
Residues n_residues	460
Spherical-harmonic order n_harmonics	20
q range q_range	— – 0.5000 Å⁻¹
Data points n_points	101
Shell type shell_type	directional
Solvent electron density solvent_density	0.3340 e/Å³
Shell contrast contrast_shell	0.0300 e/Å³
CRYSOL version crysol_version	4.1.3

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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax	89.4 Å
Rg (real space) rg_real	25.97 Å
Rg uncertainty (real space) rg_real_error	0.80 Å
I(0) (real space) i0_real	4.3440e+07
I(0) uncertainty (real space) i0_real_error	6.6920e+05
Rg (reciprocal space) rg_reciprocal	25.96 Å
I(0) (reciprocal space) i0_reciprocal	43430000.0000
Solution quality estimate total_estimate	0.8767
Solution quality rating solution_quality	GOOD a GOOD solution
P(r) peaks n_peaks	2
Primary peak position r_peak_primary	27.9 Å
Skewness Skewness skewness	0.378
Kurtosis Kurtosis kurtosis	-0.313
Angular range angular_range	— – 0.3050 Å⁻¹
Current regularization parameter α current_alpha	0.0000
Highest regularization parameter α highest_alpha	8874000.0000
Real-space data points n_real_points	62
GNOM version gnom_version	4.1.3
Quality Criteria quality_criteria	AN1: 0.000; Oscil: 0.823; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.945; Smooth: 0.977

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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (6)

Entity 1 Entity 1 polymer

Description description	Monoclonal antibody MAD21-101 Fab Heavy Chain
Molecular weight formula_weight	24225.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H
Atom count atom_count	7732

KVQLQESGPGQVKPSETLSLTCSVSGASVTVDYWSWIRQTPERGLEWIGYISYTGRTNYNPSLKSRVTISTDTAKNQVSLKLSSVTAADTAVYYCTRDRSECPDGSCFAYVMAVWGHGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC

来源 Source

来源生物 organism	Homo sapiens
通用名 common_name	human
NCBI Class编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Cricetulus griseus

Entity 2 Entity 2 polymer

Description description	Monoclonal antibody MAD21-101 Fab Light Chain
Molecular weight formula_weight	23964.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

DIVMTQSPESLAVSLGERATINCKSNQSLLYSSTNKNYLVWYLQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYLSPLTFGGGTTVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGEC

来源 Source

来源生物 organism	Homo sapiens
通用名 common_name	human
NCBI Class编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Cricetulus griseus

Entity 3 Entity 3 polymer

Description description	Circumsporozoite protein
Molecular weight formula_weight	1828.8 kDa
Source method src_method	syn
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

QPADGNPDPNANPNVDPN

Entity 4 Entity 4 branched

Description description	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose
Molecular weight formula_weight	367.3 kDa
Source method src_method	man
Copy count entity_count	1

Entity 5 Entity 5 non-polymer

Description description	1,2-ETHANEDIOL
Molecular weight formula_weight	62.1 kDa
Source method src_method	syn
Copy count entity_count	8

Entity 6 Entity 6 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	421

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8. Citations (1)

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Unit-cell length a length_a	77.493 Å
Unit-cell length b length_b	73.892 Å
Unit-cell length c length_c	86.573 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	104.13 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	4

Space group space_group	C 1 2 1
Space-group number int_tables_number	5
Crystal system crystal_system	monoclinic

Resolution resolution	1.460 Å
Low-resolution limit resolution_low	41.980 Å
R factor r_factor	0.1746
R_work r_work	0.1733
R_free r_free	0.1996

fit	/app/data/saxs_computation/c7/9c79/9c79.fit
pddf	/app/data/pr_computation/c7/9c79/9c79.pr.out
profile	/app/data/saxs_computation/c7/9c79/9c79.dat

Human monoclonal antibody MAD21-101 bound to the N-terminus of cleaved circumsporozoite protein

1. Protein Identity and Related Structures Protein Identity & Related Structures

Circumsporozoite protein

State in the Current Structure

Other States of the Same Protein in the Database

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

2. Structure Basics 2. Structure Basics

3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

5. Crystallography and Experiment 5. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

6. Entities and Polymers Entities & Polymers (6)

Entity 1 Entity 1 polymer

Polymer Polymer

来源 Source

Entity 2 Entity 2 polymer

Polymer Polymer

来源 Source

Entity 3 Entity 3 polymer

Polymer Polymer

Entity 4 Entity 4 branched

Entity 5 Entity 5 non-polymer

Entity 6 Entity 6 water

8. Citations (1)

9. Files and Curves (10)

Files (7)

Curves (3)