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9gw2

State 2 MAP 1 SETD2 bound to proximal H3 of upstream nucleosome

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Histone-lysine N-methyltransferase SETD2

Homo sapiens

UniProt Q9BYW2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 10 DNA 2 Non-Template DNA × 1 Template DNA × 1 Histone H3.2 × 2 （Q71DI3） Histone H4 × 2 （P62805） Histone H2A type 1-B/E × 2 （P04908） Histone H2B type 1-K × 2 （O60814） FACT complex subunit SPT16 × 1 （Q9Y5B9） Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
2a7o 2mdc 2mdi 2mdj 4fmu 4h12 5jle 5lss 5lsx 5lsy 5lsz 5lt6

20 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5jjy 5jlb 5v21 5v22 6j9j 6vdb 7ea8 7evr 7evr 7evs 7evs 8q5p

26 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name SETD2_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain O； PDBConstruct 4–1133； UniProt 1435–2564

Histone H3.2

Homo sapiens

UniProt Q71DI3

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 10 DNA 2 Non-Template DNA × 1 Histone-lysine N-methyltransferase SETD2 × 1 （Q9BYW2） Template DNA × 1 Histone H4 × 2 （P62805） Histone H2A type 1-B/E × 2 （P04908） Histone H2B type 1-K × 2 （O60814） FACT complex subunit SPT16 × 1 （Q9Y5B9） Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
10xz 10ya 10yb 10yc 10yd 10ye 10yf 10yg 10yh 10yi 2x4w 2x4x

158 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name H32_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain a； PDBConstruct 1–136； UniProt 1–136 Author chain e； PDBConstruct 1–136； UniProt 1–136

Histone H4

Homo sapiens

UniProt P62805

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 10 DNA 2 Non-Template DNA × 1 Histone-lysine N-methyltransferase SETD2 × 1 （Q9BYW2） Template DNA × 1 Histone H3.2 × 2 （Q71DI3） Histone H2A type 1-B/E × 2 （P04908） Histone H2B type 1-K × 2 （O60814） FACT complex subunit SPT16 × 1 （Q9Y5B9） Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
10xz 10ya 10yb 10yc 10yd 10ye 10yf 10yg 10yh 10yi 2bqz 2bqz

634 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name H4_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain b； PDBConstruct 1–103； UniProt 1–103 Author chain f； PDBConstruct 1–103； UniProt 1–103

Histone H2A type 1-B/E

Homo sapiens

UniProt P04908

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 10 DNA 2 Non-Template DNA × 1 Histone-lysine N-methyltransferase SETD2 × 1 （Q9BYW2） Template DNA × 1 Histone H3.2 × 2 （Q71DI3） Histone H4 × 2 （P62805） Histone H2B type 1-K × 2 （O60814） FACT complex subunit SPT16 × 1 （Q9Y5B9） Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2rvq 3a6n 3afa 3an2 3av1 3av2 3ayw 3aze 3azf 3azg 3azh 3azi

351 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name H2A1B_HUMAN
Isoform —
PDB entities 6
Chains and sequence ranges Author chain c； PDBConstruct 6–135； UniProt 1–130 Author chain g； PDBConstruct 6–135； UniProt 1–130

Histone H2B type 1-K

Homo sapiens

UniProt O60814

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 10 DNA 2 Non-Template DNA × 1 Histone-lysine N-methyltransferase SETD2 × 1 （Q9BYW2） Template DNA × 1 Histone H3.2 × 2 （Q71DI3） Histone H4 × 2 （P62805） Histone H2A type 1-B/E × 2 （P04908） FACT complex subunit SPT16 × 1 （Q9Y5B9） Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2cv5 6ke9 6l9h 6le9 6t79 6t7a 6t7b 6t7c 6t7d 6v92 6y5d 6y5e

83 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name H2B1K_HUMAN
Isoform —
PDB entities 7
Chains and sequence ranges Author chain d； PDBConstruct 1–126； UniProt 1–126 Author chain h； PDBConstruct 1–126； UniProt 1–126

FACT complex subunit SPT16

Homo sapiens

UniProt Q9Y5B9

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 10 DNA 2 Non-Template DNA × 1 Histone-lysine N-methyltransferase SETD2 × 1 （Q9BYW2） Template DNA × 1 Histone H3.2 × 2 （Q71DI3） Histone H4 × 2 （P62805） Histone H2A type 1-B/E × 2 （P04908） Histone H2B type 1-K × 2 （O60814） Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
4z2n 5e5b 5umt 5umu 5umu 5xm2 5xm2

7 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4z2m 8i17 8i17 8i17 8yjf 8yjm 9eh2 9gw2 9rzc 9rze 9s0u 9s3g

12 assemblies

View Construct and Data Evidence
UniProt name SP16H_HUMAN
Isoform —
PDB entities 8
Chains and sequence ranges Author chain j； PDBConstruct 3–1049； UniProt 1–1047

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9gw2
Deposition date deposition_date2024-09-26
Last revision last_revision2025-11-12
Structure title titleState 2 MAP 1 SETD2 bound to proximal H3 of upstream nucleosome
Keywords keywordsRNA Pol II Activated elongation complex Co-transcriptional H3K36me3 SETD2, TRANSCRIPTION; TRANSCRIPTION
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9gw2__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9gw2__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9gw2__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）42.07 Å
Rg (electron density)40.47 Å
Total Rg40.96 Å
Atom count24125
Residues1253
Excluded volume216890 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9gw2__assembly_1__model_1 12-meric （12） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (8)

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7. Citations (1)