Importin subunit alpha-1
Mus musculus
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count | Chain A； UniProt 70–529 | Fragment：UNP residues 70-529 | Large tegument protein deneddylase × 2 （Q9E6N3） GOL GLYCEROL × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 7；296 K；0.7 M sodium citrate, 0.1 M HEPES, 0.01 M DTT, pH 7.0 | Resolution 2.40 Å R-free 0.225 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 9OVZ | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1EJL MOUSE IMPORTIN ALPHA-SV40 LARGE T ANTIGEN NLS PEPTIDE COMPLEX Deposited 2000-03-03 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain I
70–529（460 aa）
Fragment：NLS-BINDING DOMAIN, RESIDUES 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；sodium citrate, Hepes, DTT, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.80 Å R-free 0.254 |
| 1EJY MOUSE IMPORTIN ALPHA-NUCLEOPLASMIN NLS PEPTIDE COMPLEX Deposited 2000-03-05 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain I
70–529（460 aa）
Fragment：NLS BINDING DOMAIN, RESIDUES 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；sodium citrate, Hepes, DTT, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.90 Å R-free 0.268 |
| 1IAL IMPORTIN ALPHA, MOUSE Deposited 1999-01-12 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
44–496（453 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；pH 6.0
|
Resolution 2.50 Å R-free 0.240 |
| 1IQ1 CRYSTAL STRUCTURE OF THE IMPORTIN-ALPHA(44-54)-IMPORTIN-ALPHA(70-529) COMPLEX Deposited 2001-05-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
44–54（11 aa）
Fragment：AUTOINHIBITORY PEPTIDE(RESIDUES 44-54)
Chain B
44–54（11 aa）
Fragment：AUTOINHIBITORY PEPTIDE(RESIDUES 44-54)
Chain C
70–529（460 aa）
Fragment：ARMADILLO REPEAT DOMAIN(RESIDUES 70-529)
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；sodium phosphate, DTT, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.80 Å R-free 0.248 |
| 1PJM Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex Deposited 2003-06-03 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
70–529（460 aa）
Fragment：NLS binding domain (70-529)
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；Sodium Citrate, DTT, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.50 Å R-free 0.239 |
| 1PJN Mouse Importin alpha-bipartite NLS N1N2 from Xenopus laevis phosphoprotein Complex Deposited 2003-06-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
531–552（22 aa）
Fragment：NLS (nuclear localization signal) bipartite peptide
|
Mutation：Q555G | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；Sodium Citrate, DTT, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.50 Å R-free 0.233 |
| 1Y2A Structure of mammalian importin bound to the non-classical PLSCR1-NLS Deposited 2004-11-22 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
70–497（428 aa）
Fragment：residues 70-497
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；0.6-0.7 M sodium citrate, 100 mM Hepes pH 6.0, 10 mM -mercaptoethonal, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 2.20 Å R-free 0.258 |
| 23QH Structure of importin alpha bound to the Psittacine Adenovirus B Fiber 1 protein nuclear localization signal Deposited 2026-02-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.6 M sodium citrate, 0.1 M HEPES
|
Resolution 2.10 Å R-free 0.215 |
| 2C1M Nup50:importin-alpha complex Deposited 2005-09-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
75–498（424 aa）
Fragment：DELTA IBB, RESIDUES 75-498
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
DETAILS GIVEN IN PUBLICATION
|
Resolution 2.20 Å R-free 0.254 |
| 3BTR AR-NLS:Importin-alpha complex Deposited 2007-12-30 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
70–496（427 aa）
Fragment：UNP residues 70-496
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.60 Å R-free 0.229 |
| 3KND TPX2:importin-alpha complex Deposited 2009-11-12 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
Fragment：residues 70-529
|
Not recorded | SO4 SULFATE ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；291 K；1.1-1.2 M ammonium sulphate, 100 mM Tris-Hcl, 10 mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.15 Å R-free 0.214 |
| 3L3Q Mouse importin alpha-pepTM NLS peptide complex Deposited 2009-12-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
71–497（427 aa）
Fragment：NLS binding domain (UNP residues 71-497)
|
Not recorded | FLC CITRATE ANION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；Sodium Citrate, DTT, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.30 Å R-free 0.227 |
| 3OQS Crystal structure of importin-alpha bound to a CLIC4 NLS peptide Deposited 2010-09-03 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
Fragment：NLS Binding Domain (UNP residues 70-529)
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；293 K；0.7M sodium citrate, 10mM DTT, 70mM HEPES pH 7.4, vapor diffusion, hanging drop, temperature 293K
|
Resolution 2.00 Å R-free 0.237 |
| 3Q5U A minimal NLS from human scramblase 4 complexed with importin alpha Deposited 2010-12-29 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
Fragment：unp residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；2.3 uL of deltaIBB-importin alpha concentrated to 20 mg/ml were mixed with 0.7 microlitre of a 2-fold molar excess of hPLSCR4-NLS peptide; 3 uL of reservoir solution containing ~0.8 M sodium citrate, 100 mM Hepes, and 10 mM beta-mercaptoethanol were added to the drop, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.50 Å R-free 0.226 |
| 3RZ9 Mouse importin alpha-Ku80 NLS peptide complex Deposited 2011-05-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；Sodium Citrate, DTT, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.29 Å R-free 0.218 |
| 3RZX Mouse importin alpha-Ku70 NLS peptide complex Deposited 2011-05-12 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
Fragment：NLS binding domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；Sodium Citrate, DTT, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.61 Å R-free 0.223 |
| 3TPM Crystal structure of MAL RPEL domain in complex with importin-alpha Deposited 2011-09-08 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
75–496（422 aa）
Fragment：ARM-repeat domain, UNP residues 75-496
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.4；293 K；50mM Tris-HCl, 1.4M Li2SO4, pH 7.4, VAPOR DIFFUSION, temperature 293K
|
Resolution 2.10 Å R-free 0.208 |
| 3TPO Crystal structure of D192A/E396A mutant of mouse importin alpha2 Deposited 2011-09-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–529（529 aa）
|
Mutation：D192A, E396A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7；293 K；0.1M HEPES, 1.0M KNa-tartrate, pH 7.0, VAPOR DIFFUSION, temperature 293K
|
Resolution 2.10 Å R-free 0.192 |
| 3UKW Mouse importin alpha: Bimax1 peptide complex Deposited 2011-11-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
70–529（460 aa）
Fragment：UNP Residues 70-529
|
Not recorded | BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.8M sodium citrate, 10mM DTT, 0.1M BisTris, 10% glycerol, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.10 Å R-free 0.200 |
| 3UKX Mouse importin alpha: Bimax2 peptide complex Deposited 2011-11-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
70–529（460 aa）
Fragment：UNP Residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.75M sodium citrate, 10mM DTT, 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.20 Å R-free 0.203 |
| 3UKY Mouse importin alpha: yeast CBP80 cNLS complex Deposited 2011-11-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
70–529（460 aa）
Fragment：UNP Residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.8M sodium citrate, 10mM DTT, 0.1M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.35 Å R-free 0.215 |
| 3UKZ Mouse importin alpha: mouse CBP80 cNLS complex Deposited 2011-11-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
70–529（460 aa）
Fragment：UNP Residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.82M sodium citrate, 10mM DTT, 0.1M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.30 Å R-free 0.208 |
| 3UL0 Mouse importin alpha: mouse CBP80Y8D cNLS complex Deposited 2011-11-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
70–529（460 aa）
Fragment：UNP Residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.7M sodium citrate, 10mM DTT, 0.1M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.208 |
| 3UL1 Mouse importin alpha: nucleoplasmin cNLS peptide complex Deposited 2011-11-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
70–529（460 aa）
Fragment：UNP Residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.79M sodium citrate, 10mM DTT, 0.1M HEPES, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.90 Å R-free 0.222 |
| 3UVU Structural basis of nuclear import of Flap endonuclease 1 (FEN1) Deposited 2011-11-30 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.8；293 K；Sodium citrate, DTT, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.38 Å R-free 0.215 |
| 3VE6 Crystal Structure Analysis of Venezuelan Equine Encephalitis Virus Capsid Protein NLS and Importin Alpha Deposited 2012-01-07 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
71–496（426 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；vapor diffusion, hanging drop
|
Resolution 2.83 Å R-free 0.270 |
| 3ZIN Gu_alpha_helicase Deposited 2013-01-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
72–496（425 aa）
Fragment：RESIDUES 72-496
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；0.8 M SODIUM CITRATE, 0.1 M HEPES BUFFER (PH 6.5) AND 10 MM DTT
|
Resolution 2.00 Å R-free 0.199 |
| 3ZIO minor-site specific NLS (A28) Deposited 2013-01-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
72–496（425 aa）
Fragment：RESIDUES 72-496
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；0.65 M SODIUM CITRATE, 0.1 M HEPES BUFFER (PH 6.5) AND 10 MM DTT
|
Resolution 2.10 Å R-free 0.202 |
| 3ZIP minor-site specific NLS (A58) Deposited 2013-01-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
72–497（426 aa）
Fragment：RESIDUES 72-497
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；0.75 M SODIUM CITRATE, 0.1 M HEPES BUFFER (PH 6.5) AND 10 MM DTT
|
Resolution 2.40 Å R-free 0.191 |
| 3ZIQ minor-site specific NLS (B6) Deposited 2013-01-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
72–497（426 aa）
Fragment：RESIDUES 72-497
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；0.7 M SODIUM CITRATE, 0.1 M HEPES BUFFER (PH 6.5) AND 10 MM DTT
|
Resolution 2.10 Å R-free 0.202 |
| 3ZIR minor-site specific NLS (B141) Deposited 2013-01-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
72–497（426 aa）
Fragment：RESIDUES 72-497
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；0.75 M SODIUM CITRATE, 0.1 M HEPES BUFFER (PH 6.5) AND 10 MM DTT
|
Resolution 2.30 Å R-free 0.202 |
| 4BA3 mImp_alphadIBB_A89NLS Deposited 2012-09-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
Fragment：NLS BINDING DOMAIN, RESIDUES 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
0.8 M SODIUM CITRATE, 0.1 M HEPES BUFFER, PH 6.5 AND 10 MM DTT
|
Resolution 2.10 Å R-free 0.204 |
| 4HTV Mouse importin alpha: BFDV Cap NLS peptide complex Deposited 2012-11-01 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–528（459 aa）
Fragment：UNP residues 70-528
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；290 K；0.675 M trisodium citrate, 20 mM DTT, 0.1 M HEPES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 3.00 Å R-free 0.228 |
| 4MZ5 Structure of importin-alpha: dUTPase NLS complex Deposited 2013-09-29 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
70–528（459 aa）
Fragment：UNP residues 70-528
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；Sodium citrate, DTT, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.10 Å R-free 0.232 |
| 4MZ6 Structure of importin-alpha: dUTPase S11E NLS mutant complex Deposited 2013-09-29 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
70–528（459 aa）
Fragment：UNP residues 70-528
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；Sodium citrate, DTT, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.88 Å R-free 0.195 |
| 4OIH Importin Alpha in Complex with the Bipartite NLS of Prp20 Deposited 2014-01-19 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
Fragment：UNP residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296.15 K；500mM sodium citrate, 10mM DTT, pH 6.0-8.0, VAPOR DIFFUSION, HANGING DROP, temperature 296.15K
|
Resolution 2.10 Å R-free 0.201 |
| 4U54 IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR Deposited 2014-07-24 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: Monomeric |
Chain A
74–498（425 aa）
Fragment：UNP residues 74-498
|
Not recorded | 3C5 N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；See publication for details. Precipitant was 1.05-1.2 M ammonium sulphate, 0.1M citrate pH 6.0, 20-40 mM DTT.
|
Resolution 2.41 Å R-free 0.227 |
| 4U58 IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR Deposited 2014-07-24 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: Monomeric |
Chain A
72–497（426 aa）
Fragment：UNP residues 72-497
|
Not recorded | 3C6 N~2~-[4-(pyridin-3-yl)benzoyl]-L-lysinamide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；see publication
|
Resolution 2.56 Å R-free 0.264 |
| 4U5L IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR Deposited 2014-07-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: MONOMERIC |
Chain A
72–497（426 aa）
|
Mutation：deleted IBB domain | 3D6 N~2~-[4-(pyridin-3-yl)benzyl]-L-lysinamide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；see manuscript
|
Resolution 2.53 Å R-free 0.222 |
| 4U5N IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR Deposited 2014-07-25 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: MONOMERIC |
Chain A
72–497（426 aa）
|
Not recorded | 3D4 N~2~-[4-(pyridin-3-yl)benzyl]-L-lysyl-N-[(1R,2S,3R)-1-{[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]amino}-1,3-dihydroxybutan-2-yl]glycinamide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；see manuscript
|
Resolution 2.31 Å R-free 0.221 |
| 4U5O IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR Deposited 2014-07-25 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: MONOMERIC |
Chain A
72–497（426 aa）
|
Not recorded | 3D5 N~2~-[4-(pyridin-3-yl)benzyl]-D-lysinamide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；see manuscript
|
Resolution 2.00 Å R-free 0.247 |
| 4U5S IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR Deposited 2014-07-25 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: Monomeric |
Chain A
72–497（426 aa）
Fragment：UNP residues 72-497
|
Not recorded | 3D0 N-[(2S)-2-[(N~2~-acetyl-D-lysyl)amino]-3-(pyridin-3-ylmethoxy)propyl]-L-allothreonyl-D-phenylalaninamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；see manuscript
|
Resolution 2.12 Å R-free 0.231 |
| 4U5U IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR Deposited 2014-07-25 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: Monomeric |
Chain A
72–497（426 aa）
Fragment：UNP residues 72-497
|
Not recorded | 3D2 N~2~-[3-(pyridin-3-yl)benzyl]-L-lysinamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；see manuscript
|
Resolution 1.96 Å R-free 0.215 |
| 4U5V IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR Deposited 2014-07-25 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: Monomeric |
Chain A
72–497（426 aa）
Fragment：UNP residues 72-497
|
Not recorded | RH2 N~2~-{[5-(pyridin-3-yl)thiophen-2-yl]methyl}-L-lysinamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；see manuscript
|
Resolution 1.97 Å R-free 0.259 |
| 4UAF Importin alpha 1 delta IBB in complex with Influenza PB2 nuclear localization domain Deposited 2014-08-08 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
69–529（461 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；0.49 M Na phosphate monobasic
0.91 M K phosphate dibasic
pH 6.9
|
Resolution 1.70 Å R-free 0.193 |
| 4YI0 Structure of mouse importin a1 bound to Pom121NLS Deposited 2015-02-27 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
70–529（460 aa）
Fragment：unp residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；293 K；0.1 M sodium citrate tribasic dihydrate, 0.7 M sodium citrate tribasic dihydrate, 25 mM DTT
|
Resolution 1.81 Å R-free 0.210 |
| 4ZDU Crystal structure of importin-alpha bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein Deposited 2015-04-19 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
72–498（427 aa）
Fragment：UNP residues 72-498
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；PEG 4000
|
Resolution 2.30 Å R-free 0.246 |
| 5B56 Crystal structure of HIV-1 VPR C-Terminal domain and DIBB-M-Importin-Alpha2 complex Deposited 2016-04-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
70–529（460 aa）
Fragment：UNP RESIDUES 70-529
Chain B
70–529（460 aa）
Fragment：UNP RESIDUES 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.2；293 K；50MM MES, 100MM AMMONIUM SULFATE, 10MM
MGCL2, 20-23%(W/V) PEG8000, 5MM DTT
|
Resolution 2.30 Å R-free 0.226 |
| 5CTT Crystal structure of human SART3/TIP110 NLS-mouse importin alpha complex Deposited 2015-07-24 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
72–497（426 aa）
Fragment：UNP residues 72-497
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100mM HEPES, pH 6.6, 1.6M sodium citrate, 10mM DTT
|
Resolution 1.70 Å R-free 0.219 |
| 5D5K Crystal Structure NLS from human PARP-2 complexed with Importin alpha delta IBB Deposited 2015-08-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
70–529（460 aa）
Fragment：unp residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.6；295 K；0.6-0.7M sodium citrate, 0.1M sodium citrate buffer pH 5.6, and 7-10mM DTT
|
Resolution 1.90 Å R-free 0.171 |
| 5E6Q Importin alpha binding to XRCC1 NLS peptide Deposited 2015-10-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
70–529（460 aa）
|
Not recorded | SO4 SULFATE ION × 1 GOL GLYCEROL × 1 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；1.5M Ammonium sulfate, 0.1M bis-tris propane
|
Resolution 2.31 Å R-free 0.208 |
| 5EKF Crystallization and X-ray Diffraction Data Collection of Importin-alpha from Mus musculus Complexed with a XPG NLS Peptide, fragment 1 Deposited 2015-11-03 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
Fragment：UNP residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.6-0.7 M sodium citrate, 10 mM DTT
|
Resolution 2.00 Å R-free 0.192 |
| 5EKG Crystallization and X-ray Diffraction Data Collection of Importin-alpha from Mus musculus Complexed with a XPG NLS Peptide, fragment 2 Deposited 2015-11-03 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
Fragment：UNP residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.6-0.7 M sodium citrate, 10 mM DTT
|
Resolution 2.80 Å R-free 0.228 |
| 5FC8 Mouse importin alpha: Dengue 3 NS5 C-terminal NLS peptide complex Deposited 2015-12-15 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
71–529（459 aa）
Fragment：UNP residues 71-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；296 K；1 M sodium citrate, 10 mM DTT
|
Resolution 2.10 Å R-free 0.207 |
| 5GXW Importin and NuMA complex Deposited 2016-09-20 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–497（428 aa）
Fragment：UNP residues 70-497
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；1M KCl, 0.8M ammonium sulfate, 100mM Hepes, pH 7.0
|
Resolution 2.39 Å R-free 0.218 |
| 5HHG Mouse importin alpha: Dengue 2 NS5 C-terminal NLS peptide complex Deposited 2016-01-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
71–497（427 aa）
Fragment：UNP residues 71-497
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；296 K；1.5M Ammonium Sulfate, 0.1M Sodium HEPES
|
Resolution 2.20 Å R-free 0.214 |
| 5HUW Structure of HSV-1 Large Terminase NLS bound to importin alpha Deposited 2016-01-27 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
2–529（528 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；0.6M sodium citrate, 100 mM Hepes, pH 6.0, and 10 mM beta-mercaptoethanol
|
Resolution 1.95 Å R-free 0.195 |
| 5HUY Structure of HCMV Small Terminase NLS bound to importin alpha Deposited 2016-01-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
2–529（528 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；2.3 uL of deltaIBB-importin alpha concentrated to 20 mg/ml were mixed with 0.7 microlitre of a 2-fold molar excess of HCMV-NLS peptide; 3 uL of reservoir solution containing ~0.7 M sodium citrate, 100 mM Hepes, and 10 mM beta-mercaptoethanol were added to the drop, pH 6.0
|
Resolution 1.98 Å R-free 0.196 |
| 5K9S Importin-alpha in complex with HNF1-beta peptide Deposited 2016-06-01 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
72–529（458 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291.15 K；10% PEG 8K, 0.09 M NPS, 20% ethylene glycol, 0.1 M Buffer 1 (Morpheus I)
|
Resolution 2.40 Å R-free 0.221 |
| 5KLR Prototypical P4[R]cNLS Deposited 2016-06-25 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
70–529（460 aa）
Fragment：UNP residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；10mM DTT, 1M sodium citrate pH7.0
|
Resolution 2.20 Å R-free 0.185 |
| 5KLT Prototypical P4[M]cNLS Deposited 2016-06-25 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
70–529（460 aa）
Fragment：UNp residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；296 K；1M Sodium citrate pH6, 10mM DTT
|
Resolution 2.60 Å R-free 0.228 |
| 5SVZ HIV-1 Tat NLS in complex with importin alpha Deposited 2016-08-08 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；1.25 M sodium citrate pH 7 and 10 mM DTT
|
Resolution 2.00 Å R-free 0.192 |
| 5U5P Crystal Structure and X-ray Diffraction Data Collection of Importin-alpha from Mus Musculus Complexed with a MLH1 NLS Peptide Deposited 2016-12-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
Fragment：residues 70-529
|
Not recorded | DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.600-0.625 M sodium citrate (pH 6)
10 mM DTT
|
Resolution 2.17 Å R-free 0.211 |
| 5U5R Crystal Structure and X-ray Diffraction Data Collection of Importin-alpha from Mus musculus Complexed with a PMS2 NLS Peptide Deposited 2016-12-07 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.600-0.625 M sodium citrate (pH 6) and
10 mM DTT
|
Resolution 2.10 Å R-free 0.207 |
| 5UMZ Structure of TNRC6A NLS in complex with importin-alpha Deposited 2017-01-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
70–528（459 aa）
Fragment：UNP residues 70-528
|
Not recorded | GOL GLYCEROL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；sodium citrate, Hepes 7.0, 10mM DTT
|
Resolution 1.90 Å R-free 0.182 |
| 5V5O Structure of NLS2K of influenza A virus nucleoprotein bound to importin alpha Deposited 2017-03-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
2–529（528 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；0.1 M HEPES pH 6.0, 0.6 M sodium citrate tribasic dihydrate, 10 mM b-mercaptoethanol
|
Resolution 2.24 Å R-free 0.206 |
| 5V5P Structure of NLS2R of influenza A virus nucleoprotein bound to importin alpha Deposited 2017-03-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
2–529（528 aa）
Fragment：residues 2-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；0.6 M sodium citrate, 100 mM Hepes, and 10 mM beta-mercaptoethanol
|
Resolution 2.15 Å R-free 0.210 |
| 5W41 Zika MR766 NLS in complex with Importin alpha subunit-1 Deposited 2017-06-08 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；1M Sodium citrate, 0.01M DTT, pH6.5
|
Resolution 2.20 Å R-free 0.203 |
| 5W4E Importin binding to Tdt NLS peptide Deposited 2017-06-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
71–529（459 aa）
|
Not recorded | GOL GLYCEROL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.1 M HEPES
0.7 M Sodium Citrate
|
Resolution 2.18 Å R-free 0.192 |
| 5W4F Importin binding to pol Mu NLS peptide Deposited 2017-06-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
70–529（460 aa）
|
Not recorded | GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.1 M HEPES
0.8 M Sodium Citrate
|
Resolution 1.98 Å R-free 0.199 |
| 5W4G Importin binding to NLS peptide of DNA polymerase lambda Deposited 2017-06-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
70–529（460 aa）
|
Not recorded | SO4 SULFATE ION × 4 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.1 M Bis Tris Propane
1.4 M Ammonium Sulfate
|
Resolution 2.04 Å R-free 0.200 |
| 5WUM Crystal structure of mouse importin-alpha1 bound to S385-phosphorylated NLS of EBNA1 Deposited 2016-12-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；MES, sodium citrate, DTT
|
Resolution 2.00 Å R-free 0.211 |
| 5WUN Crystal structure of mouse importin-alpha1 bound to non-phosphorylated NLS of EBNA1 Deposited 2016-12-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
Fragment：UNP RESIDUES 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；MES, sodium citrate, DTT
|
Resolution 2.20 Å R-free 0.204 |
| 5X8N Crystal structure of mouse importin-alpha1 bound to the nuclear localization signal of Epstein-Barr virus EBNA-LP protein Deposited 2017-03-03 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
Fragment：UNP residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；MES, sodium citrate, DTT
|
Resolution 2.15 Å R-free 0.210 |
| 6BVT Importin alpha 1 in cargo free state Deposited 2017-12-13 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain E
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.01M DTT, 0.1M sodium HEPES, 1M Ammonium Sulfate
|
Resolution 2.50 Å R-free 0.213 |
| 6BW0 Nipah virus W protein C-terminus in complex with Importin alpha 1 Deposited 2017-12-14 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.01M DTT, 0.1M sodium HEPES pH7, 0.7M sodium citrate
|
Resolution 2.10 Å R-free 0.203 |
| 6BW1 Hendra virus W protein C-terminus in complex with Importin alpha 1 Deposited 2017-12-14 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.01M DTT, 0.1M sodium HEPES pH7, 0.7M sodium citrate
|
Resolution 2.20 Å R-free 0.212 |
| 6D7M Crystal structure of the W184R/W231R Importin alpha mutant Deposited 2018-04-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
70–529（460 aa）
|
Mutation：W184R, W231R | EDO 1,2-ETHANEDIOL × 3 CL CHLORIDE ION × 1 SIN SUCCINIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1M Bis-Tris-Propane, 1.0M Sodium Succinate
|
Resolution 2.19 Å R-free 0.222 |
| 6D7N Crystal structure of the W357R/W399R Importin alpha mutant Deposited 2018-04-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
70–529（460 aa）
|
Mutation：W357R, W399R | EDO 1,2-ETHANEDIOL × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；1.0M triammonium citrate, 0.1M Bis-Tris-Propane
|
Resolution 2.30 Å R-free 0.217 |
| 6IU7 Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (wild-type) Deposited 2018-11-27 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
72–498（427 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.7；293 K；sodium citrate, HEPES, DTT
|
Resolution 1.90 Å R-free 0.185 |
| 6IUA Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (S1678D) Deposited 2018-11-27 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
72–498（427 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.7；293 K；sodium citrate, HEPES, DTT
|
Resolution 1.70 Å R-free 0.179 |
| 6IW8 Crystal structure of Importin-alpha and wild-type GM130 Deposited 2018-12-04 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
70–498（429 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；0.1M Sodium malonate, 12% w/v Polyethylene glycol 3350 (pH 7.0)
|
Resolution 2.80 Å R-free 0.255 |
| 6IWA Crystal structure of Importin-alpha and phosphoserine GM130 Deposited 2018-12-05 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
70–498（429 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；0.1M Sodium citrate tribasic dihydrate, 16% w/v Polyethylene glycol 8000 (pH 5.5)
|
Resolution 2.40 Å R-free 0.216 |
| 6K06 Crystal structure of Importin-alpha and phosphomimetic GM130 Deposited 2019-05-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
70–498（429 aa）
|
Mutation：S25D | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；0.2M Potassium thiocyante, 20% w/v Polyethylene glycol 3350
|
Resolution 1.75 Å R-free 0.199 |
| 6MJL Crystal structure of ChREBP NLS peptide bound to importin alpha. Deposited 2018-09-21 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
72–497（426 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；500 mM Na Citrate
10 mM DTT
20 mM HEPES pH 6.5
|
Resolution 2.50 Å R-free 0.244 |
| 6P6A Structure of Mouse Importin alpha - NIT2 NLS peptide complex Deposited 2019-06-03 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；Sodium Citrate, DTT, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.15 Å R-free 0.196 |
| 6P6E Structure of Mouse Importin alpha - PAC3 NLS peptide complex Deposited 2019-06-03 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；Sodium Citrate, DTT, ph 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.99 Å R-free 0.197 |
| 6WBA Structure of Mouse Importin alpha MLH1- R470A NLS Peptide Complex Deposited 2020-03-26 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；0.1 M sodium citrate (pH 6), 0.6 M
sodium citrate and 10 mM DTT
|
Resolution 2.15 Å R-free 0.197 |
| 6WBB Structure of Mouse Importin alpha - MLH1-E475A NLS peptide complex Deposited 2020-03-26 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain I
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；0.1 M sodium citrate (pH 6),
10 mM DTT,
0.55 M sodium citrate
|
Resolution 2.66 Å R-free 0.227 |
| 6WBC Structure of Mouse Importin alpha- MLH1-R472K NLS Peptide Complex Deposited 2020-03-26 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；0.1 M sodium citrate (pH 6), 0.575 M
sodium citrate , 10 mM DTT
|
Resolution 2.15 Å R-free 0.213 |
| 6WX7 SOX2 bound to Importin-alpha 2 Deposited 2020-05-09 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；750mM sodium citrate (pH7), 10 mM DTT
|
Resolution 2.70 Å R-free 0.227 |
| 7JJM Crystal structure of Importin alpha 2 in complex with LSD1 NLS Deposited 2020-07-27 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
62–529（468 aa）
|
Not recorded | CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；295 K；0.7 M sodium citrate, 0.01M DTT, 0.1M sodium HEPES pH 7
|
Resolution 2.06 Å R-free 0.259 |
| 7JK7 Crystal structure of Importin alpha 2 in complex with LSD1 NLS S111E mutant Deposited 2020-07-27 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
62–529（468 aa）
|
Not recorded | GOL GLYCEROL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；295 K；0.7 M sodium citrate, 0.01M DTT, 0.1M sodium HEPES pH 7
|
Resolution 1.96 Å R-free 0.206 |
| 7JVO Importin alpha bound to the C-terminus of ACE2 Deposited 2020-08-22 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；600 mM citrate, pH 7.0
|
Resolution 2.20 Å R-free 0.210 |
| 7L04 Crystal Structure of Adeno-Associated Virus Porcine Origin capsid protein in complex with Importin-alpha 2 Deposited 2020-12-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.6M Na citrate, 0.01M DTT, 0.1M HEPES pH 6.5
|
Resolution 2.26 Å R-free 0.234 |
| 7LEQ Structure of importin a2 bound to p50 NLS Deposited 2021-01-14 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
70–497（428 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.6M sodium citrate, 100 Hepes pH 6.0
|
Resolution 2.24 Å R-free 0.219 |
| 7LET Structure of importin a2 bound to the p50- and p65-NLSs Deposited 2021-01-15 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
70–497（428 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；0.6 Na Citrate, 100 mM HEPES pH 6
|
Resolution 2.40 Å R-free 0.241 |
| 7LEU Structure of importin a2 bound to p65-NLS Deposited 2021-01-15 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
70–497（428 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；0.55M Na citrate, 100mM HEPES pH 6.0
|
Resolution 2.82 Å R-free 0.236 |
| 7M60 Structure of Mouse Importin alpha MLH1-S467A NLS Peptide Complex Deposited 2021-03-25 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；0.1M sodium citrate pH6, 0.65 M sodium citrate, 10 mM DTT
|
Resolution 2.30 Å R-free 0.207 |
| 7RFX Importin alpha2 in complex with MERS ORF4B Deposited 2021-07-14 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.7M sodium citrate (pH 7.0) and 10 mM DTT
|
Resolution 2.10 Å R-free 0.208 |
| 7RFZ Importin alpha 2 in complex with MERS ORF4B NLS peptide Deposited 2021-07-14 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.65 M Sodium Citrate, 0.1 M HEPES, pH 7.0
|
Resolution 1.95 Å R-free 0.211 |
| 7RG0 Importin alpha2 in complex with MERS ORF4B R24A mutant Deposited 2021-07-14 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.6 M Sodium Citrate, 0.1 M HEPES, pH 7.0
|
Resolution 2.00 Å R-free 0.213 |
| 7RG1 Importin alpha2 in complex with MERS ORF4B H26A mutant Deposited 2021-07-14 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.7 M Sodium Citrate, 0.1 M HEPES, pH 7.5
|
Resolution 1.85 Å R-free 0.211 |
| 7RG2 Importin alpha2 in complex with MERS ORF4B R33A mutant Deposited 2021-07-14 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.7 M Sodium Citrate, 0.1 M HEPES pH 6.5
|
Resolution 2.00 Å R-free 0.216 |
| 7RG3 Importin alpha2 in complex with MERS ORF4B R37A mutant Deposited 2021-07-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.7 M Sodium Citrate, 0.1 M HEPES, pH 7.5
|
Resolution 2.00 Å R-free 0.194 |
| 7RG4 Importin alpha2 in complex with p50 NLS Deposited 2021-07-14 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.7 M sodium citrate, 0.01M DTT, 0.1M sodium HEPES pH 7
|
Resolution 2.60 Å R-free 0.243 |
| 7RG6 Importin alpha2 in complex with ORF4B Bat coronavirus HKU5 Deposited 2021-07-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.1M HEPES pH6.5, 0.6M Citrate, 0.01M DTT
|
Resolution 2.10 Å R-free 0.223 |
| 7TMX Structure of Mouse Importin alpha NEIL1 NLS Peptide Complex Deposited 2022-01-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain I
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；sodium citrate buffer (pH 6.0), sodium citrate and DTT
|
Resolution 2.30 Å R-free 0.254 |
| 7TMY Structure of Mouse Importin alpha NEIL3 NLS Peptide Complex Deposited 2022-01-20 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain I
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；sodium citrate buffer (pH 6.0), sodium citrate and DTT
|
Resolution 2.21 Å R-free 0.217 |
| 7UMI Importin a1 bound to Cp183-CTD Deposited 2022-04-07 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.6 M sodium citrate, 0.1 M HEPES pH 7.2, 10 mM DTT
|
Resolution 1.99 Å R-free 0.215 |
| 8ECH Tick-borne encephalitis virus capsid protein NLS bound to host importin alpha 2 Deposited 2022-09-02 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；295.15 K；0.7 M sodium citrate, 0.1 M HEPES, pH 6.5
|
Resolution 2.05 Å R-free 0.219 |
| 8F2Q Human Parvovirus B19 Nonstructural NS1 Protein NLS bound to Importin Alpha 2 Deposited 2022-11-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；296 K；0.7M sodium citrate, 0.1M HEPES pH6.5, 0.01M DTT
|
Resolution 2.70 Å R-free 0.229 |
| 8FK3 Adeno-Associated Virus Porcine Origin capsid protein basic regions in complex with Importin-alpha 2 Deposited 2022-12-20 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.75M Na Citrate, 0.01M DTT, 0.1M HEPES pH 6.5
|
Resolution 2.60 Å R-free 0.249 |
| 8FUA Crystal structure of mouse Importin alpha in complex with Hendra virus matrix protein NLS1 Deposited 2023-01-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.1M sodium HEPES, 0.72M sodium citrate, 1% dithiothreitol
|
Resolution 1.90 Å R-free 0.190 |
| 8FUC Crystal structure of mouse Importin alpha in complex with Hendra virus matrix protein minor site NLS2 Deposited 2023-01-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.72M sodium citrate,
0.1M sodium HEPES, 1% dithiothreitol
|
Resolution 2.10 Å R-free 0.217 |
| 8G8Q Monopartite p52 NLS in complex with Importin alpha 2 Deposited 2023-02-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；295 K；0.01M DTT, 0.1M sodium HEPES pH7.5, 0.8.5M sodium citrate
|
Resolution 2.60 Å R-free 0.210 |
| 8G8R RelB NLS in complex with Importin alpha 2 Deposited 2023-02-19 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；295 K；0.01M DTT, 0.1M sodium HEPES pH7.5, 0.8.5M sodium citrate
|
Resolution 2.60 Å R-free 0.213 |
| 8G8S bipartite p52 NLS in complex with Importin alpha 2 Deposited 2023-02-19 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；295 K；0.01M DTT, 0.1M sodium HEPES pH7, 0.6M sodium citrate
|
Resolution 2.10 Å R-free 0.186 |
| 8HE0 Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (wild-type) Deposited 2022-11-07 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
72–498（427 aa）
Fragment：UNP residues 72-498
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.7；293 K；tri-sodium citrate, HEPES, DTT
|
Resolution 1.80 Å R-free 0.198 |
| 8HE3 Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (delta 724-751) Deposited 2022-11-07 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
72–498（427 aa）
Fragment：UNP residues 72-498
|
Not recorded | SO4 SULFATE ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；ammonium sulfate, HEPES, DTT
|
Resolution 1.90 Å R-free 0.207 |
| 8Q8K KI Polyomavirus LTA NLS bound to importin alpha 2 Deposited 2023-08-18 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.2 M NaCl, 0.1 M Tris pH 8.0, 16 % PEG4000. Protein stock pre-treated with 5:1 molar ratio IMPa: ivermectin
|
Resolution 2.70 Å R-free 0.247 |
| 8Q8K KI Polyomavirus LTA NLS bound to importin alpha 2 Deposited 2023-08-18 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.2 M NaCl, 0.1 M Tris pH 8.0, 16 % PEG4000. Protein stock pre-treated with 5:1 molar ratio IMPa: ivermectin
|
Resolution 2.70 Å R-free 0.247 |
| 8QXW HCMV DNA polymerase processivity factor UL44 unphosphorylated NLS 410-433 bound to mouse importin alpha 2 Deposited 2023-10-25 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；Sodium citrate 0.65M, HEPES pH7.5, DTT 0.01M
|
Resolution 2.00 Å R-free 0.221 |
| 8QXX HCMV DNA polymerase processivity factor UL44 phosphorylated NLS 410-433 bound to mouse importin alpha 2 Deposited 2023-10-25 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；Sodium citrate 0.65M, HEPES pH7.0, DTT 0.01M
|
Resolution 1.90 Å R-free 0.204 |
| 8SG7 Adeno-Associated Virus Bat origin capsid protein basic regions in complex with importin-alpha 2 Deposited 2023-04-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.75M Na Citrate, 0.01M DTT, 0.1M HEPES, pH7.5
|
Resolution 2.40 Å R-free 0.223 |
| 8SUD JC Polyomavirus LTA NLS bound to importin alpha 2 Deposited 2023-05-12 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.85 M sodium citrate, 0.1 M HEPES pH 7.5, 0.01 M DTT
|
Resolution 2.10 Å R-free 0.218 |
| 8SV0 The crystal structure of the classical binding interface of Importin alpha 2 and nuclear localisation signal sequence in Psittacine siadenovirus core protein VII Deposited 2023-05-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
70–529（460 aa）
|
Not recorded | NA SODIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；296 K；0.6 M sodium citrate, 0.1 M sodium HEPES, 1% dithiothreitol
|
Resolution 2.20 Å R-free 0.242 |
| 8TUQ STL Polyomavirus LTA NLS bound to importin alpha 2 Deposited 2023-08-17 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.80 M sodium citrate, 0.1 M HEPES pH 6.5, 0.01 M DTT
|
Resolution 2.00 Å R-free 0.200 |
| 8TUR Merkel Cell Polyomavirus LTA bipartite NLS bound to importin alpha 2 Deposited 2023-08-17 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.65 M sodium citrate, 0.1 M HEPES pH 6.5, 0.01 M DTT
|
Resolution 2.15 Å R-free 0.208 |
| 8TUS WU Polyomavirus LTA NLS bound to importin alpha 2 Deposited 2023-08-17 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.75 M sodium citrate, 0.1 M HEPES pH 7.0, 0.01 M DTT
|
Resolution 2.60 Å R-free 0.238 |
| 8TUT Merkel Cell Polyomavirus LTA NLSct bound to importin alpha 2 Deposited 2023-08-17 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.70 M sodium citrate, 0.10 M HEPES pH 7.0, 0.01 M DTT
|
Resolution 2.55 Å R-free 0.225 |
| 8TUU MW Polyomavirus LTA bipartite NLS bound to importin alpha 2 Deposited 2023-08-17 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.7 M sodium citrate, 0.1 M HEPES pH 7.5, 0.01 M DTT
|
Resolution 2.50 Å R-free 0.235 |
| 8TUV Merkel Cell Polyomavirus LTA NLSm bound to importin alpha 2 Deposited 2023-08-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.75 M sodium citrate, 0.1 M HEPES pH 6.5, 0.01 M DTT
|
Resolution 2.30 Å R-free 0.218 |
| 8U36 The crystal structure of the classical binding interface of Importin alpha 2 and a nuclear localisation signal sequence in Frog siadenovirus core protein VII Deposited 2023-09-07 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
Fragment：UNP residues 70-529
|
Not recorded | NA SODIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；296 K；0.65 M sodium citrate, 0.1 M sodium HEPES, 1% dithiothreitol
|
Resolution 2.60 Å R-free 0.242 |
| 8VPR Crystal structure of mouse Importin alpha in complex with Dengue 1 NS5 central NLS peptide Deposited 2024-01-16 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
Fragment：UNP residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；296 K；0.75 M sodium citrate, 0.1 M HEPES
|
Resolution 2.70 Å R-free 0.242 |
| 8VPU Crystal structure of mouse Importin alpha in complex with dengue virus 3 NS5 central NLS peptide Deposited 2024-01-17 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
Fragment：UNP residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；296 K；0.75 sodium citrate, 0.1 M HEPES
|
Resolution 2.10 Å R-free 0.208 |
| 9CFT Adeno-associated virus serotype 6 basic regions in complex with importin alpha 2 Deposited 2024-06-27 | Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
Fragment：UNP residues 70-529
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.65 M Na citrate, 0.01 M DTT, 0.1 M HEPES, pH 7.0
|
Resolution 2.30 Å R-free 0.238 |
| 9CL8 Importin alpha isoform 2 with synthetic zero net-charge nuclear localization signal Deposited 2024-07-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
|
Not recorded | GOL GLYCEROL × 4 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.4；296 K；0.8 M NaCit, 0.1M HEPES pH 6.4, 60% glycerol, 10 mM DTT
|
Resolution 2.11 Å R-free 0.192 |
| 9CLE Importin alpha isoform 2 with synthetic zero net-charge nuclear localization signal Deposited 2024-07-11 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
|
Not recorded | GOL GLYCEROL × 7 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.6；296 K；0.7 M NaCit, 0.1 M HEPES pH 6.6, 60% glycerol, 10 mM DTT
|
Resolution 2.34 Å R-free 0.205 |
| 9CLF Importin alpha isoform 2 with synthetic zero net-charge nuclear localization signal Deposited 2024-07-11 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
|
Not recorded | GOL GLYCEROL × 3 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；296 K；0.65 M NaCit, 0.1 M HEPES pH 7.0, 60% glycerol, 10 mM DTT
|
Resolution 2.36 Å R-free 0.208 |
| 9CLG Importin alpha isoform 2 with synthetic zero net-charge nuclear localization signal Deposited 2024-07-11 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
70–529（460 aa）
|
Not recorded | GOL GLYCEROL × 6 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.2；296 K；0.8 M NaCit, 0.1 M HEPES pH 6.2, 60% glycerol, 10 mM DTT
|
Resolution 2.42 Å R-free 0.202 |
| 9MIK Gallid alphaherpesvirus-1 large tegument protein bipartite NLS1 in complex with Importin alpha Deposited 2024-12-12 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
70–529（460 aa）
Fragment：UNP residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；296 K；0.6 M sodium citrate, 0.1 M HEPES
|
Resolution 2.60 Å R-free 0.212 |
| 9MKA Gallid alphaherpesvirus-1 large tegument protein NLS 1 in complex with Importin alpha Deposited 2024-12-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
71–497（427 aa）
Fragment：UNP residues 71-497
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；296 K；0.6 M sodium citrate, 0.1 M HEPES
|
Resolution 2.50 Å R-free 0.208 |
| 9N54 Bipartite p63 NLS in complex with Importin Alpha 2 Deposited 2025-02-03 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
70–529（460 aa）
Fragment：UNP residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；296 K；0.65 M sodium citrate, 0.1 M HEPES and 10 mM DTT
|
Resolution 2.20 Å R-free 0.206 |
| 9NIB Black sea bass polyomavirus LTA NLS bound to improtin alpha 2 Deposited 2025-02-25 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
Fragment：UNP residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.65 M Na citrate, 0.01 M DTT, 0.1 M HEPES, pH 7.0
|
Resolution 2.20 Å R-free 0.216 |
| 9NZ1 Adeno-associated virus serotype 11 basic regions in complex with importin alpha 2 Deposited 2025-03-31 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
Fragment：UNP residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；295 K；0.65 M Na citrate, 0.01 M DTT, 0.1 M HEPES pH 7.0
|
Resolution 2.68 Å R-free 0.239 |
| 9PYR Importin alpha 2 in complex with Haliotid herpesvirus 1 large tegument protein NLS region Deposited 2025-08-08 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
70–529（460 aa）
Fragment：UNP residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；296 K；0.6M sodium citrate, 0.1M HEPES pH 7.0, and 10mM DTT
|
Resolution 2.60 Å R-free 0.217 |
| 9Y0R Importin alpha 2 in complex with ATF2 basic region Deposited 2025-08-29 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
Fragment：UNP residues 70-529
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；sodium citrate 0.7 M, 0.1 M HEPES, 10 mM DTT, pH 7
|
Resolution 2.20 Å R-free 0.222 |
| 9Y7K Importin a2 in complex with Guertu virus non-structural S (NSs) NLS peptide Deposited 2025-09-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；296 K；0.70 M sodium citrate, 0.01 M DTT, 0.1 M HEPES, pH 7.0
|
Resolution 2.25 Å R-free 0.205 |
| 9YTZ Structure of Ovine gammaherpesvirus 2 ORF73 LANA bound to importin alpha 2 Deposited 2025-10-22 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.6M sodium citrate, 0.1M HEPES pH 7.0, and 10mM DTT
|
Resolution 2.85 Å R-free 0.265 |
| 9YY4 Importin a2 in complex with Lone Star virus non-structural S (NSs) NLS peptide Deposited 2025-10-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
70–529（460 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；296 K；0.75 M sodium citrate, 0.01 M DTT, 0.1 M HEPES, pH 7.0
|
Resolution 2.35 Å R-free 0.229 |
150 other PDB entries and 151 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | IMA1_MOUSE |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 51–510； UniProt 70–529 |
