当前蛋白身份:P29055 重新检索
本组结构的主要差异维度
构建体不同 组装状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
3K7A Crystal Structure of an RNA polymerase II-TFIIB complex 提交 2009-10-12 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 11 PDB 声明:undecameric(11) 与蛋白数一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 9 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.9;295 K;1.2 M sodium/potassium phosphate, pH 6.9, VAPOR DIFFUSION, HANGING DROP, temperature 295K
分辨率 3.80 Å R-free 0.313
4BBR Structure of RNA polymerase II-TFIIB complex 提交 2012-09-27 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 13 PDB 声明:tridecameric(13) 与蛋白数一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 9 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 3.40 Å R-free 0.211
4BBS Structure of an initially transcribing RNA polymerase II-TFIIB complex 提交 2012-09-27 Assembly 1 其他组合 异源复合物;蛋白 × 13 PDB 声明:hexadecameric(16) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 9 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 3.60 Å R-free 0.225
4V1N Architecture of the RNA polymerase II-Mediator core transcription initiation complex 提交 2014-09-29 Assembly 1 其他组合 异源复合物;蛋白 × 16 PDB 声明:nonadecameric(19) 与全部聚合物一致
链 M 1–345(345 aa)
链 Q 1–734(734 aa)
未记录 ZN ZINC ION × 9 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 25 MM HEPES-KOH PH 7.5, 180 MM POTASSIUM ACETATE, 5 % GLYCEROL, 5 MM DTT;pH 7.5;25 MM HEPES-KOH PH 7.5, 180 MM POTASSIUM ACETATE, 5 % GLYCEROL, 5 MM DTT
cryo-EM玻璃化条件 冷冻剂 ETHANE;GRIDS WERE GLOW- DISCHARGED FOR 20 S BEFORE DEPOSITION OF 4 MICROLITERS SAMPLE AND INCUBATED FOR 30 S. GRIDS WERE WASHED TWICE WITH 4 MICROLITERS DISTILLED WATER, BLOTTED, AND VITRIFIED BY PLUNGING INTO LIQUID ETHANE WITH A MANUAL PLUNGER.
分辨率 7.80 Å
4V1O Architecture of the RNA polymerase II-Mediator core transcription initiation complex 提交 2014-09-29 Assembly 1 其他组合 异源复合物;蛋白 × 23 PDB 声明:26-meric(26) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 9 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 25 MM HEPES-KOH PH 7.5, 180 MM POTASSIUM ACETATE, 5 % GLYCEROL, 5 MM DTT;pH 7.5;25 MM HEPES-KOH PH 7.5, 180 MM POTASSIUM ACETATE, 5 % GLYCEROL, 5 MM DTT
cryo-EM玻璃化条件 冷冻剂 ETHANE;GRIDS WERE GLOW- DISCHARGED FOR 20 S BEFORE DEPOSITION OF 4 MICROLITERS SAMPLE AND INCUBATED FOR 30 S. GRIDS WERE WASHED TWICE WITH 4 MICROLITERS DISTILLED WATER, BLOTTED, AND VITRIFIED BY PLUNGING INTO LIQUID ETHANE WITH A MANUAL PLUNGER.
分辨率 9.70 Å
5FMF the P-lobe of RNA polymerase II pre-initiation complex 提交 2015-11-03 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 25 PDB 声明:27-meric(27) 与全部聚合物一致
链 P 1–345(345 aa)
未记录 MG MAGNESIUM ION × 2 ZN ZINC ION × 9 ELECTRON MICROSCOPY
cryo-EM缓冲液 20 MM HEPES (PH7.6), 5 MM DTT, 2 MM MG(OAC)2,AND 40 MM KOAC;pH 7.6;20 MM HEPES (PH7.6), 5 MM DTT, 2 MM MG(OAC)2,AND 40 MM KOAC
cryo-EM玻璃化条件 冷冻剂 ETHANE;VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 100, TEMPERATURE- 120, INSTRUMENT- FEI VITROBOT MARK III,
分辨率 6.00 Å
5FYW Transcription initiation complex structures elucidate DNA opening (OC) 提交 2016-03-10 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 20 PDB 声明:22-meric(22) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 10 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 25 MM HEPES-KOH PH 7.5, 150 MM POTASSIUM ACETATE, 2 MM MGCL2, 5 MM DTT;pH 7.5;25 MM HEPES-KOH PH 7.5, 150 MM POTASSIUM ACETATE, 2 MM MGCL2, 5 MM DTT
cryo-EM玻璃化条件 冷冻剂 ETHANE;CRYOGEN - ETHANE. INSTRUMENT - FEI VITROBOT MARK IV. QUANTIFOIL R 3.5- 1 HOLEY CARBON GRIDS WERE GLOW-DISCHARGED BEFORE DEPOSITION OF 4.5 MICROLITERS OF SAMPLE. GRIDS WERE THEN BLOTTED FOR 8.5 S AND PLUNGE- FROZEN IN LIQUID ETHANE.
分辨率 4.35 Å
5FZ5 Transcription initiation complex structures elucidate DNA opening (CC) 提交 2016-03-10 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 20 PDB 声明:22-meric(22) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 10 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 25 MM HEPES-KOH PH 7.5, 150 MM POTASSIUM ACETATE, 2 MM MGCL2, 5 MM DTT;pH 7.5;25 MM HEPES-KOH PH 7.5, 150 MM POTASSIUM ACETATE, 2 MM MGCL2, 5 MM DTT
cryo-EM玻璃化条件 冷冻剂 ETHANE;LIQUID ETHANE
分辨率 8.80 Å
5OQJ STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH 提交 2017-08-11 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 29 PDB 声明:31-meric(31) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 16 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE;GRIDS WERE BLOTTED FOR 8 S AND PLUNGE-FROZEN IN LIQUID ETHANE.
分辨率 4.70 Å
5OQM STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH AND CORE MEDIATOR 提交 2017-08-13 Assembly 1 信息不足 异源复合物;蛋白 × 44 PDB 声明:46-meric(46) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 16 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE;Grids were blotted for 8 s and plunge-frozen in liquid ethane.
分辨率 5.80 Å
5SVA Mediator-RNA Polymerase II Pre-Initiation Complex 提交 2016-08-05 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 38 PDB 声明:40-meric(40) 与全部聚合物一致
链 c 1–345(345 aa)
未记录 ZN ZINC ION × 8 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 15.30 Å
6GYK Structure of a yeast closed complex (core CC1) 提交 2018-06-30 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 18 PDB 声明:eicosameric(20) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 9 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 5.10 Å
6GYL Structure of a yeast closed complex with distorted DNA (core CCdist) 提交 2018-06-30 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 20 PDB 声明:22-meric(22) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 10 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.80 Å
6GYM Structure of a yeast closed complex with distorted DNA (CCdist) 提交 2018-06-30 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 29 PDB 声明:31-meric(31) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 SF4 IRON/SULFUR CLUSTER × 1 ZN ZINC ION × 16 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 6.70 Å
7ML0 RNA polymerase II pre-initiation complex (PIC1) 提交 2021-04-27 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 26 PDB 声明:28-meric(28) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 17 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.00 Å
7ML1 RNA polymerase II pre-initiation complex (PIC2) 提交 2021-04-27 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 28 PDB 声明:30-meric(30) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 19 SF4 IRON/SULFUR CLUSTER × 1 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.00 Å
7ML2 RNA polymerase II pre-initiation complex (PIC3) 提交 2021-04-27 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 28 PDB 声明:30-meric(30) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 17 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.40 Å
7ML4 RNA polymerase II initially transcribing complex (ITC) 提交 2021-04-27 Assembly 1 其他组合 异源复合物;蛋白 × 28 PDB 声明:31-meric(31) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 15 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.10 Å
7O4I Yeast RNA polymerase II transcription pre-initiation complex with initial transcription bubble 提交 2021-04-06 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 28 PDB 声明:30-meric(30) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 SF4 IRON/SULFUR CLUSTER × 1 ZN ZINC ION × 17 BEF BERYLLIUM TRIFLUORIDE ION × 1 MG MAGNESIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.20 Å
7O4J Yeast RNA polymerase II transcription pre-initiation complex (consensus) 提交 2021-04-06 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 28 PDB 声明:30-meric(30) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 SF4 IRON/SULFUR CLUSTER × 1 ZN ZINC ION × 17 BEF BERYLLIUM TRIFLUORIDE ION × 1 MG MAGNESIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.90 Å
7O72 Yeast RNA polymerase II transcription pre-initiation complex with closed promoter DNA 提交 2021-04-12 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 28 PDB 声明:30-meric(30) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 SF4 IRON/SULFUR CLUSTER × 1 ZN ZINC ION × 17 BEF BERYLLIUM TRIFLUORIDE ION × 1 MG MAGNESIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.40 Å
7O73 Yeast RNA polymerase II transcription pre-initiation complex with closed distorted promoter DNA 提交 2021-04-12 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 28 PDB 声明:30-meric(30) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 SF4 IRON/SULFUR CLUSTER × 1 ZN ZINC ION × 17 BEF BERYLLIUM TRIFLUORIDE ION × 1 MG MAGNESIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.40 Å
7O75 Yeast RNA polymerase II transcription pre-initiation complex with open promoter DNA 提交 2021-04-13 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 28 PDB 声明:30-meric(30) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 SF4 IRON/SULFUR CLUSTER × 1 ZN ZINC ION × 17 BEF BERYLLIUM TRIFLUORIDE ION × 1 MG MAGNESIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.20 Å
7UI9 Core Mediator-PICearly (Copy A) 提交 2022-03-28 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 33 PDB 声明:33-meric(33) 与蛋白数一致
链 M 1–345(345 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.30 Å
7UIF Mediator-PIC Early (Core B) 提交 2022-03-29 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 33 PDB 声明:33-meric(33) 与蛋白数一致
链 M 1–345(345 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.60 Å
7UIO Mediator-PIC Early (Composite Model) 提交 2022-03-29 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 78 PDB 声明:80-meric(80) 与全部聚合物一致
链 AM 1–345(345 aa)
链 BM 1–345(345 aa)
未记录 ZN ZINC ION × 4 THR THREONINE × 1 ALA ALANINE × 1 ASP ASPARTIC ACID × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.30 Å
7ZS9 Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome (complex A) 提交 2022-05-06 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 36 PDB 声明:38-meric(38) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 17 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.10 Å
7ZSA Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome and NTP (complex B) 提交 2022-05-06 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 36 PDB 声明:38-meric(38) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 17 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.00 Å
7ZSB Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome and NTP, complex C 提交 2022-05-06 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 36 PDB 声明:38-meric(38) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 17 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 6.60 Å
8CEN Yeast RNA polymerase II transcription pre-initiation complex with core Mediator 提交 2023-02-02 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 44 PDB 声明:46-meric(46) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 SF4 IRON/SULFUR CLUSTER × 1 ZN ZINC ION × 17 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.00 Å
8CEO Yeast RNA polymerase II transcription pre-initiation complex with core Mediator and the +1 nucleosome 提交 2023-02-02 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 52 PDB 声明:54-meric(54) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 SF4 IRON/SULFUR CLUSTER × 1 ZN ZINC ION × 17 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.60 Å
8UMH Consensus map of PICdeltaTFIIK form2 提交 2023-10-17 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 28 PDB 声明:30-meric(30) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 15 MG MAGNESIUM ION × 2 SF4 IRON/SULFUR CLUSTER × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6;20 mM HEPES PH 7.6 50 mM KOAc 5 mM DTT 2 mM MgOAc
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.10 Å
8UMI consensus map of PICdeltaTFIIK form1 提交 2023-10-17 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 28 PDB 声明:30-meric(30) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 SF4 IRON/SULFUR CLUSTER × 1 ZN ZINC ION × 15 MG MAGNESIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6;20 mM HEPES PH 7.6 50 mM KOAc 5 mM DTT 2 mM MgOAc
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.70 Å
8UOQ Composite map of PIC_delta_TFIIK form2 提交 2023-10-20 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 28 PDB 声明:30-meric(30) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 ZN ZINC ION × 15 MG MAGNESIUM ION × 2 SF4 IRON/SULFUR CLUSTER × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.80 Å
8UOT Composite map of PICdeltaTFIIK form1 提交 2023-10-20 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 28 PDB 声明:30-meric(30) 与全部聚合物一致
链 M 1–345(345 aa)
未记录 SF4 IRON/SULFUR CLUSTER × 1 ZN ZINC ION × 15 MG MAGNESIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6;20 mM HEPES PH 7.6 50 mM KOAc 5 mM DTT 2 mM MgOAc
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.70 Å