8cen

Yeast RNA polymerase II transcription pre-initiation complex with core Mediator

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

General transcription and DNA repair factor IIH helicase subunit XPD

Saccharomyces cerevisiae

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RAD3_YEAST
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain 0； PDBConstruct 1–778； UniProt 1–778

General transcription and DNA repair factor IIH helicase subunit XPB

Saccharomyces cerevisiae

UniProt Q00578

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RAD25_YEAST
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain 7； PDBConstruct 1–843； UniProt 1–843

DNA-directed RNA polymerase II subunit RPB1

OrganismNot specified

UniProt P04050

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPB1_YEAST
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain A； PDBConstruct 1–1733； UniProt 1–1733

DNA-directed RNA polymerase II subunit RPB2

OrganismNot specified

UniProt P08518

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPB2_YEAST
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain B； PDBConstruct 1–1224； UniProt 1–1224

DNA-directed RNA polymerase II subunit RPB3

OrganismNot specified

UniProt P16370

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPB3_YEAST
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain C； PDBConstruct 33–347； UniProt 4–318

DNA-directed RNA polymerase II subunit RPB4

OrganismNot specified

UniProt P20433

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPB4_YEAST
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain D； PDBConstruct 1–221； UniProt 1–221

DNA-directed RNA polymerases I, II, and III subunit RPABC1

OrganismNot specified

UniProt P20434

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB1_YEAST
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain E； PDBConstruct 1–215； UniProt 1–215

DNA-directed RNA polymerases I, II, and III subunit RPABC2

OrganismNot specified

UniProt P20435

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB2_YEAST
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain F； PDBConstruct 1–155； UniProt 1–155

DNA-directed RNA polymerase II subunit RPB7

OrganismNot specified

UniProt P34087

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPB7_YEAST
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain G； PDBConstruct 1–171； UniProt 1–171

DNA-directed RNA polymerases I, II, and III subunit RPABC3

OrganismNot specified

UniProt P20436

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB3_YEAST
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain H； PDBConstruct 1–146； UniProt 1–146

DNA-directed RNA polymerase II subunit RPB9

OrganismNot specified

UniProt P27999

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPB9_YEAST
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain I； PDBConstruct 1–122； UniProt 1–122

DNA-directed RNA polymerases I, II, and III subunit RPABC5

OrganismNot specified

UniProt P22139

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB5_YEAST
Isoform	—
PDB entities	18
Chains and sequence ranges	Author chain J； PDBConstruct 1–70； UniProt 1–70

DNA-directed RNA polymerase II subunit RPB11

OrganismNot specified

UniProt P38902

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPB11_YEAST
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain K； PDBConstruct 1–120； UniProt 1–120

DNA-directed RNA polymerases I, II, and III subunit RPABC4

OrganismNot specified

UniProt P40422

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB4_YEAST
Isoform	—
PDB entities	20
Chains and sequence ranges	Author chain L； PDBConstruct 1–70； UniProt 1–70

Transcription initiation factor IIB

Saccharomyces cerevisiae

UniProt P29055

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TF2B_YEAST
Isoform	—
PDB entities	21
Chains and sequence ranges	Author chain M； PDBConstruct 1–345； UniProt 1–345

TATA-binding protein

Saccharomyces cerevisiae

UniProt G4XSG8

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	G4XSG8_YEASX
Isoform	—
PDB entities	23
Chains and sequence ranges	Author chain O； PDBConstruct 1–240； UniProt 1–240

Transcription initiation factor IIF subunit beta

Saccharomyces cerevisiae

UniProt P41896

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	T2FB_YEAST
Isoform	—
PDB entities	25
Chains and sequence ranges	Author chain R； PDBConstruct 1–400； UniProt 1–400

Transcription initiation factor IIA subunit 2

Saccharomyces cerevisiae

UniProt A0A6A5PRZ0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIE subunit alpha × 1 （P36100） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A6A5PRZ0_YEASX
Isoform	—
PDB entities	28
Chains and sequence ranges	Author chain V； PDBConstruct 1–122； UniProt 1–122

Transcription initiation factor IIE subunit alpha

Saccharomyces cerevisiae

UniProt P36100

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit beta × 1 （P36145） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	T2EA_YEAST
Isoform	—
PDB entities	29
Chains and sequence ranges	Author chain W； PDBConstruct 1–482； UniProt 1–482

Transcription initiation factor IIE subunit beta

Saccharomyces cerevisiae

UniProt P36145

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 44 DNA 2	General transcription and DNA repair factor IIH helicase subunit XPD × 1 （P06839） General transcription and DNA repair factor IIH subunit TFB1 × 1 General transcription and DNA repair factor IIH subunit TFB2 × 1 RNA polymerase II transcription factor B subunit 3 × 1 General transcription and DNA repair factor IIH subunit TFB4 × 1 General transcription and DNA repair factor IIH subunit TFB5 × 1 General transcription and DNA repair factor IIH subunit SSL1 × 1 General transcription and DNA repair factor IIH helicase subunit XPB × 1 （Q00578） DNA-directed RNA polymerase II subunit RPB1 × 1 （P04050） DNA-directed RNA polymerase II subunit RPB2 × 1 （P08518） DNA-directed RNA polymerase II subunit RPB3 × 1 （P16370） DNA-directed RNA polymerase II subunit RPB4 × 1 （P20433） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P20434） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P20435） DNA-directed RNA polymerase II subunit RPB7 × 1 （P34087） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P20436） DNA-directed RNA polymerase II subunit RPB9 × 1 （P27999） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P22139） DNA-directed RNA polymerase II subunit RPB11 × 1 （P38902） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P40422） Transcription initiation factor IIB × 1 （P29055） NONTEMPLATE DNA (209-MER) × 1 TATA-binding protein × 1 （G4XSG8） Transcription initiation factor IIF subunit alpha × 1 Transcription initiation factor IIF subunit beta × 1 （P41896） TEMPLATE DNA (209-MER) × 1 Transcription initiation factor IIA large subunit × 1 Transcription initiation factor IIA subunit 2 × 1 （A0A6A5PRZ0） Transcription initiation factor IIE subunit alpha × 1 （P36100） Mediator of RNA polymerase II transcription subunit 6 × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 Mediator of RNA polymerase II transcription subunit 11 × 1 Mediator of RNA polymerase II transcription subunit 17 × 1 Mediator of RNA polymerase II transcription subunit 18 × 1 Mediator of RNA polymerase II transcription subunit 20 × 1 Mediator of RNA polymerase II transcription subunit 22 × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 Mediator of RNA polymerase II transcription subunit 7 × 1 Mediator of RNA polymerase II transcription subunit 9 × 1 Mediator of RNA polymerase II transcription subunit 10 × 1 Mediator of RNA polymerase II transcription subunit 14 × 1 Mediator of RNA polymerase II transcription subunit 19 × 1 Mediator of RNA polymerase II transcription subunit 21 × 1 Mediator of RNA polymerase II transcription subunit 31 × 1 Mediator of RNA polymerase II transcription subunit 1 × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 17 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	T2EB_YEAST
Isoform	—
PDB entities	30
Chains and sequence ranges	Author chain X； PDBConstruct 1–328； UniProt 1–328

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	8cen
Deposition date deposition_date	2023-02-02
Structure title title	Yeast RNA polymerase II transcription pre-initiation complex with core Mediator
Keywords keywords	PIC, Mediator, TF, TRANSCRIPTION; TRANSCRIPTION
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8cen__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8cen__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

8cen__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	89.73 Å
Rg (electron density)	89.91 Å
Total Rg	89.83 Å
Atom count	101943
Residues	12457
Excluded volume	1816200 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`8cen__assembly_1__model_1`	46-meric （46）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (49)

Entity 1 Entity 1 polymer

Description description	General transcription and DNA repair factor IIH helicase subunit XPD
Molecular weight formula_weight	89899.0 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	0
Atom count atom_count	101943

MKFYIDDLPVLFPYPKIYPEQYNYMCDIKKTLDVGGNSILEMPSGTGKTVSLLSLTIAYQMHYPEHRKIIYCSRTMSEIEKALVELENLMDYRTKELGYQEDFRGLGLTSRKNLCLHPEVSKERKGTVVDEKCRRMTNGQAKRKLEEDPEANVELCEYHENLYNIEVEDYLPKGVFSFEKLLKYCEEKTLCPYFIVRRMISLCNIIIYSYHYLLDPKIAERVSNEVSKDSIVIFDEAHNIDNVCIESLSLDLTTDALRRATRGANALDERISEVRKVDSQKLQDEYEKLVQGLHSADILTDQEEPFVETPVLPQDLLTEAIPGNIRRAEHFVSFLKRLIEYLKTRMKVLHVISETPKSFLQHLKQLTFIERKPLRFCSERLSLLVRTLEVTEVEDFTALKDIATFATLISTYEEGFLLIIEPYEIENAAVPNPIMRFTCLDASIAIKPVFERFSSVIITSGTISPLDMYPRMLNFKTVLQKSYAMTLAKKSFLPMIITKGSDQVAISSRFEIRNDPSIVRNYGSMLVEFAKITPDGMVVFFPSYLYMESIVSMWQTMGILDEVWKHKLILVETPDAQETSLALETYRKACSNGRGAILLSVARGKVSEGIDFDHQYGRTVLMIGIPFQYTESRILKARLEFMRENYRIRENDFLSFDAMRHAAQCLGRVLRGKDDYGVMVLADRRFSRKRSQLPKWIAQGLSDADLNLSTDMAISNTKQFLRTMAQPTDPKDQEGVSVWSYEDLIKHQNSRKDQGGFIENENKEGEQDEDEDEDIEMQ

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Trichoplusia ni

Entity 2 Entity 2 polymer

Description description	General transcription and DNA repair factor IIH subunit TFB1
Molecular weight formula_weight	72993.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	1

MSHSGAAIFEKVSGIIAINEDVSPAELTWRSTDGDKVHTVVLSTIDKLQATPASSEKMMLRLIGKVDESKKRKDNEGNEVVPKPQRHMFSFNNRTVMDNIKMTLQQIISRYKDADIYEEKRRREESAQHTETPMSSSSVTAGTPTPHLDTPQLNNGAPLINTAKLDDSLSKEKLLTNLKLQQSLLKGNKVLMKVFQETVINAGLPPSEFWSTRIPLLRAFALSTSQKVGPYNVLSTIKPVASSENKVNVNLSREKILNIFENYPIVKKAYTDNVPKNFKEPEFWARFFSSKLFRKLRGEKIMQNDRGDVIIDRYLTLDQEFDRKDDDMLLHPVKKIIDLDGNIQDDPVVRGNRPDFTMQPGVDINGNSDGTVDILKGMNRLSEKMIMALKNEYSRTNLQNKSNITNDEEDEDNDERNELKIDDLNESYKTNYAIIHLKRNAHEKTTDNDAKSSADSIKNADLKVSNQQMLQQLSLVMDNLINKLDLNQVVPNNEVSNKINKRVITAIKINAKQAKHNNVNSALGSFVDNTSQANELEVKSTLPIDLLESCRMLHTTCCEFLKHFYIHFQSGEQKQASTVKKLYNHLKDCIEKLNELFQDVLNGDGESMSNTCTAYLKPVLNSITLATHKYDEYFNEYNNNSN

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Trichoplusia ni

Entity 3 Entity 3 polymer

Description description	General transcription and DNA repair factor IIH subunit TFB2
Molecular weight formula_weight	58602.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	2

MSDYSLKHSVTQYLEEIPQQVQNRLYTSPATCLAIYRILPPLAKFFIMAMVFNENEVPLLDLDKWVNSNGKLQFQNAIKSMKSLHLLIPNKSSGTLMINLNPTFKISLRNALTGGEVQNSFGVVVEENVVSLDLLDEYSANKWETILHFMVGTPLAKIPSEKVLNLLKHSKLMEEVNSTGEFKITNEGFQFLLQEINSQLWTLLLQYLKMIETSKMDLVDVLHFIFMLGALEVGKAYKIDALSETQRIMLQDMRDYGLVFQKHSNDSIFYPTKLALMLTSDTKTIRSASNAMDSVLRQNREEPSVNEDGANGKSTTDITTSDDLNKAGLKNQDIPDGSLIVETNFKIYSYSNSPLQIAVLSLFVHLKARFVNMVLGQITRESIRRALTNGITADQIIAYLETHAHPQMRRLAEEKLEKKLELDPNCKEPLQVLPPTVVDQIRLWQLELDRVITYEGSLYSDFETSQEYNLLSKYAQDIGVLLWKDDKKKKFFISKEGNSQVLDFAKRKLKKKQ

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Trichoplusia ni

Entity 4 Entity 4 polymer

Description description	RNA polymerase II transcription factor B subunit 3
Molecular weight formula_weight	38188.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	3

MLMDEYEENKDMCPICKTDRYLSPDVKFLVNPECYHRICESCVDRIFSLGPAQCPYKGCDKILRKNKFKTQIFDDVEVEKEVDIRKRVFNVFNKTIDDFNGDLVEYNKYLEEVEDIIYKLDHGIDVAKTEEKLRTYEELNKQLIMNNLERSRTEIESFEQRQKFEKEMKLKKRLLERQIEEEERMNKEWTKKEIVNRLSTTTQDINETIEGVKNTVKLKKSSARRKLEELNRVLKNNPYFNSNVNVQNSRLKDAVPFTPFNGDREAHPRFTLKGSVYNDPFIKDLEHRKEFIASGFNTNYAYERVLTEAFMGLGCVISEEL

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Trichoplusia ni

Entity 5 Entity 5 polymer

Description description	General transcription and DNA repair factor IIH subunit TFB4
Molecular weight formula_weight	37506.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	4

MDAISDPTFKHARSRKQVTEESPSLLTVIIEIAPKLWTTFDEEGNEKGSIIKVLEALIVFLNAHLAFNSANKVAVIAAYSQGIKYLYPESTSALKASESENKTRSDLKIINSDMYRRFRNVDETLVEEIYKLFELEKKQIEQNSQRSTLAGAMSAGLTYVNRISKESVTTSLKSRLLVLTCGSGSSKDEIFQYIPIMNCIFSATKMKCPIDVVKIGGSKESTFLQQTTDATNGVYLHVESTEGLIQYLATAMFIDPSLRPIIVKPNHGSVDFRTSCYLTGRVVAVGFICSVCLCVLSIIPPGNKCPACDSQFDEHVIAKLKRKPVVPRLKAKKKVTKP

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Trichoplusia ni

Entity 6 Entity 6 polymer

Description description	General transcription and DNA repair factor IIH subunit TFB5
Molecular weight formula_weight	8243.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	5

MARARKGALVQCDPSIKALILQIDAKMSDIVLEELDDTHLLVNPSKVEFVKHELNRLLSKNIYNPMDEEENQ

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Trichoplusia ni

Entity 7 Entity 7 polymer

Description description	General transcription and DNA repair factor IIH subunit SSL1
Molecular weight formula_weight	52370.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	6

MAPVVISESEEDEDRVAITRRTKRQVHFDGEGDDRVDQQQQQHSSSHRDRDKHVQRKKKKRLSNRNLQGSNGGYAWEDEIKRSWDLVKVDDEGDMASLVASIVEARKKRTAKKNITPYQRGIIRSLILTLDCSEAMLEKDLRPNRHAMIIQYAIDFVHEFFDQNPISQMGIIIMRNGLAQLVSQVSGNPQDHIDALKSIRKQEPKGNPSLQNALEMARGLLLPVPAHCTREVLIVFGSLSTTDPGDIHQTIDSLVSEKIRVKVLGLSAQVAICKELCKATNYGDESFYKILLDETHLKELFNEAVTPLPVNKINKGFTLVKMGFPTRIFEDTPTFCSCHSKLVYGGYFCPNCHSKVCSLPTVCPCCDLMLILSTHLARSYHHLMPLKTFAEVPTTEKFRSEDCFSCQSRFPILKNHKNGKLLTSSRYRCEDCKQEFCVDCDVFIHEILHNCPGCESKPVIT

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Trichoplusia ni

Entity 8 Entity 8 polymer

Description description	General transcription and DNA repair factor IIH helicase subunit XPB
Molecular weight formula_weight	95461.7 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	7

MTDVEGYQPKSKGKIFPDMGESFFSSDEDSPATDAEIDENYDDNRETSEGRGERDTGAMVTGLKKPRKKTKSSRHTAADSSMNQMDAKDKALLQDTNSDIPADFVPDSVSGMFRSHDFSYLRLRPDHASRPLWISPSDGRIILESFSPLAEQAQDFLVTIAEPISRPSHIHEYKITAYSLYAAVSVGLETDDIISVLDRLSKVPVAESIINFIKGATISYGKVKLVIKHNRYFVETTQADILQMLLNDSVIGPLRIDSDHQVQPPEDVLQQQLQQTAGKPATNVNPNDVEAVFSAVIGGDNEREEEDDDIDAVHSFEIANESVEVVKKRCQEIDYPVLEEYDFRNDHRNPDLDIDLKPSTQIRPYQEKSLSKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSVIVLCTSSVSVMQWRQQFLQWCTLQPENCAVFTSDNKEMFQTESGLVVSTYSMVANTRNRSHDSQKVMDFLTGREWGFIILDEVHVVPAAMFRRVVSTIAAHAKLGLTATLVREDDKIGDLNFLIGPKLYEANWMELSQKGHIANVQCAEVWCPMTAEFYQEYLRETARKRMLLYIMNPTKFQACQFLIQYHERRGDKIIVFSDNVYALQEYALKMGKPFIYGSTPQQERMNILQNFQYNDQINTIFLSKVGDTSIDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTQEMYYSTKRQAFLVDQGYAFKVITHLHGMENIPNLAYASPRERRELLQEVLLKNEEAAGIEVGDDADNSVGRGSNGHKRFKSKAVRGEGSLSGLAGGEDMAYMEYSTNKNKELKEHHPLIRKMYYKNLKK

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Trichoplusia ni

Entity 9 Entity 9 polymer

Description description	DNA-directed RNA polymerase II subunit RPB1
Molecular weight formula_weight	191821.6 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A

MVGQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETMDETQTRAKIGGLNDPRLGSIDRNLKCQTCQEGMNECPGHFGHIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNELMRQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDDPTQLVSRGGCGNTQPTIRKDGLKLVGSWKKDRATGDADEPELRVLSTEEILNIFKHISVKDFTSLGFNEVFSRPEWMILTCLPVPPPPVRPSISFNESQRGEDDLTFKLADILKANISLETLEHNGAPHHAIEEAESLLQFHVATYMDNDIAGQPQALQKSGRPVKSIRARLKGKEGRIRGNLMGKRVDFSARTVISGDPNLELDQVGVPKSIAKTLTYPEVVTPYNIDRLTQLVRNGPNEHPGAKYVIRDSGDRIDLRYSKRAGDIQLQYGWKVERHIMDNDPVLFNRQPSLHKMSMMAHRVKVIPYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPCMGIVQDTLCGIRKLTLRDTFIELDQVLNMLYWVPDWDGVIPTPAIIKPKPLWSGKQILSVAIPNGIHLQRFDEGTTLLSPKDNGMLIIDGQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVCAKLFGNIQKVVNFWLLHNGFSTGIGDTIADGPTMREITETIAEAKKKVLDVTKEAQANLLTAKHGMTLRESFEDNVVRFLNEARDKAGRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMSACVGQQSVEGKRIAFGFVDRTLPHFSKDDYSPESKGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDNTTRNSLGNVIQFIYGEDGMDAAHIEKQSLDTIGGSDAAFEKRYRVDLLNTDHTLDPSLLESGSEILGDLKLQVLLDEEYKQLVKDRKFLREVFVDGEANWPLPVNIRRIIQNAQQTFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRGKNEIIQNAQRDAVTLFCCLLRSRLATRRVLQEYRLTKQAFDWVLSNIEAQFLRSVVHPGEMVGVLAAQSIGEPATQMTLNTFHFAGVASKKVTSGVPRLKEILNVAKNMKTPSLTVYLEPGHAADQEQAKLIRSAIEHTTLKSVTIASEIYYDPDPRSTVIPEDEEIIQLHFSLLDEEAEQSFDQQSPWLLRLELDRAAMNDKDLTMGQVGERIKQTFKNDLFVIWSEDNDEKLIIRCRVVRPKSLDAETEAEEDHMLKKIENTMLENITLRGVENIERVVMMKYDRKVPSPTGEYVKEPEWVLETDGVNLSEVMTVPGIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVYNVIASDGSYVNYRHMALLVDVMTTQGGLTSVTRHGFNRSNTGALMRCSFEETVEILFEAGASAELDDCRGVSENVILGQMAPIGTGAFDVMIDEESLVKYMPEQKITEIEDGQDGGVTPYSNESGLVNADLDVKDELMFSPLVDSGSNDAMAGGFTAYGGADYGEATSPFGAYGEAPTSPGFGVSSPGFSPTSPTYSPTSPAYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPAYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPGYSPGSPAYSPKQDEQKHNENENSR

Entity 10 Entity 10 polymer

Description description	DNA-directed RNA polymerase II subunit RPB2
Molecular weight formula_weight	138937.3 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MSDLANSEKYYDEDPYGFEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEDSTLILEQLAQHTTESDNISRKYEISFGKIYVTKPMVNESDGVTHALYPQEARLRNLTYSSGLFVDVKKRTYEAIDVPGRELKYELIAEESEDDSESGKVFIGRLPIMLRSKNCYLSEATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSALEKGSRFISTLQVKLYGREGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKELKVRKGHIAKLMATEYQDIEGGFEDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAEANEENDLDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRLYTDRSRDF

Entity 11 Entity 11 polymer

Description description	DNA-directed RNA polymerase II subunit RPB3
Molecular weight formula_weight	38635.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MGSHHHHHHSNSGLNDIFEAQKIEWHEDTGSSEGPQVKIREASKDNVDFILSNVDLAMANSLRRVMIAEIPTLAIDSVEVETNTTVLADEFIAHRLGLIPLQSMDIEQLEYSRDCFCEDHCDKCSVVLTLQAFGESESTTNVYSKDLVIVSNLMGRNIGHPIIQDKEGNGVLICKLRKGQELKLTCVAKKGIAKEHAKWGPAAAIEFEYDPWNKLKHTDYWYEQDSAKEWPQSKNCEYEDPPNEGDPFDYKAQADTFYMNVESVGSIPVDQVVVRGIDTLQKKVASILLALTQMDQDKVNFASGDNNTASNMLGSNEDVMMTGAEQDPYSNASQMGNTGSGGYDNAW

Entity 12 Entity 12 polymer

Description description	DNA-directed RNA polymerase II subunit RPB4
Molecular weight formula_weight	25451.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MNVSTSTFQTRRRRLKKVEEEENAATLQLGQEFQLKQINHQGEEEELIALNLSEARLVIKEALVERRRAFKRSQKKHKKKHLKHENANDETTAVEDEDDDLDEDDVNADDDDFMHSETREKELESIDVLLEQTTGGNNKDLKNTMQYLTNFSRFRDQETVGAVIQLLKSTGLHPFEVAQLGSLACDTADEAKTLIPSLNNKISDDELERILKELSNLETLY

Entity 13 Entity 13 polymer

Description description	DNA-directed RNA polymerases I, II, and III subunit RPABC1
Molecular weight formula_weight	25117.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Entity 14 Entity 14 polymer

Description description	DNA-directed RNA polymerases I, II, and III subunit RPABC2
Molecular weight formula_weight	17931.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQHEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Entity 15 Entity 15 polymer

Description description	DNA-directed RNA polymerase II subunit RPB7
Molecular weight formula_weight	19909.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MFFIKDLSLNITLHPSFFGPRMKQYLKTKLLEEVEGSCTGKFGYILCVLDYDNIDIQRGRILPTDGSAEFNVKYRAVVFKPFKGEVVDGTVVSCSQHGFEVQVGPMKVFVTKHLMPQDLTFNAGSNPPSYQSSEDVITIKSRIRVKIEGCISQVSSIHAIGSIKEDYLGAIHHHHHH

Entity 16 Entity 16 polymer

Description description	DNA-directed RNA polymerases I, II, and III subunit RPABC3
Molecular weight formula_weight	16525.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIASSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGGLLMRLEGNYRNLNNLKQENAYLLIRR

Entity 17 Entity 17 polymer

Description description	DNA-directed RNA polymerase II subunit RPB9
Molecular weight formula_weight	14308.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MTTFRFCRDCNNMLYPREDKENNRLLFECRTCSYVEEAGSPLVYRHELITNIGETAGVVQDIGSDPTLPRSDRECPKCHSRENVFFQSQQRRKDTSMVLFFVCLSCSHIFTSDQKNKRTQFS

Entity 18 Entity 18 polymer

Description description	DNA-directed RNA polymerases I, II, and III subunit RPABC5
Molecular weight formula_weight	8290.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKFLRYNPLEKRD

Entity 19 Entity 19 polymer

Description description	DNA-directed RNA polymerase II subunit RPB11
Molecular weight formula_weight	13633.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MNAPDRFELFLLGEGESKLKIDPDTKAPNAVVITFEKEDHTLGNLIRAELLNDRKVLFAAYKVEHPFFARFKLRIQTTEGYDPKDALKNACNSIINKLGALKTNFETEWNLQTLAADDAF

Entity 20 Entity 20 polymer

Description description	DNA-directed RNA polymerases I, II, and III subunit RPABC4
Molecular weight formula_weight	7730.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR

Entity 21 Entity 21 polymer

Description description	Transcription initiation factor IIB
Molecular weight formula_weight	39215.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M

MMTRESIDKRAGRRGPNLNIVLTCPECKVYPPKIVERFSEGDVVCALCGLVLSDKLVDTRSEWRTFSNDDHNGDDPSRVGEASNPLLDGNNLSTRIGKGETTDMRFTKELNKAQGKNVMDKKDNEVQAAFAKITMLCDAAELPKIVKDCAKEAYKLCHDEKTLKGKSMESIMAASILIGCRRAEVARTFKEIQSLIHVKTKEFGKTLNIMKNILRGKSEDGFLKIDTDNMSGAQNLTYIPRFCSHLGLPMQVTTSAEYTAKKCKEIKEIAGKSPITIAVVSIYLNILLFQIPITAAKVGQTLQVTEGTIKSGYKILYEHRDKLVDPQLIANGVVSLDNLPGVEKKKHHHHHH

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 22 Entity 22 polymer

Description description	NONTEMPLATE DNA (209-MER)
Molecular weight formula_weight	64291.0 kDa
Source method src_method	syn
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	N

AGCACGCTGTGTATATAATAGCTATGGAACGTTCGATTCACCTCCGATGTGTGTTGTACATACATAAAAATATCATAGCTCTTCTGCGCTGTGTTGGTCGTAGACAGCTCTAGCACCGCTTAAACGCACGTACGCGCTGTCCCCCGCGTTTTAACCGCCAAGGGGATTACTCCCTAGTCTCCAGGCACGTGTCAGATATATACATCGAT

Entity 23 Entity 23 polymer

Description description	TATA-binding protein
Molecular weight formula_weight	27042.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O

MADEERLKEFKEANKIVFDPNTRQVWENQNRDGTKPATTFQSEEDIKRAAPESEKDTSATSGIVPTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKIGFAAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEIYQAFEAIYPVLSEFRKM

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 24 Entity 24 polymer

Description description	Transcription initiation factor IIF subunit alpha
Molecular weight formula_weight	82320.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

MSRRNPPGSRNGGGPTNASPFIKRDRMRRNFLRMRMGQNGSNSSSPGVPNGDNSRGSLVKKDDPEYAEEREKMLLQIGVEADAGRSNVKVKDEDPNEYNEFPLRAIPKEDLENMRTHLLKFQSKKKINPVTDFHLPVRLHRKDTRNLQFQLTRAEIVQRQKEISEYKKKAEQERSTPNSGGMNKSGTVSLNNTVKDGSQTPTVDSVTKDNTANGVNSSIPTVTGSSVPPASPTTVSAVESNGLSNGSTSAANGLDGNASTANLANGRPLVTKLEDAGPAEDPTKVGMVKYDGKEVTNEPEFEEGTMDPLADVAPDGGGRAKRGNLRRKTRQLKVLDENAKKLRFEEFYPWVMEDFDGYNTWVGSYEAGNSDSYVLLSVEDDGSFTMIPADKVYKFTARNKYATLTIDEAEKRMDKKSGEVPRWLMKHLDNIGTTTTRYDRTRRKLKAVADQQAMDEDDRDDNSEVELDYDEEFADDEEAPIIDGNEQENKESEQRIKKEMLQANAMGLRDEEAPSENEEDELFGEKKIDEDGERIKKALQKTELAALYSSDENEINPYLSESDIENKENESPVKKEEDSDTLSKSKRSSPKKQQKKATNAHVHKEPTLRVKSIKNCVIILKGDKKILKSFPEGEWNPQTTKAVDSSNNASNTVPSPIKQEEGLNSTVAEREETPAPTITEKDIIEAIGDGKVNIKEFGKFIRRKYPGAENKKLMFAIVKKLCRKVGNDHMELKKE

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 25 Entity 25 polymer

Description description	Transcription initiation factor IIF subunit beta
Molecular weight formula_weight	46684.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	R

MSSGSAGAPALSNNSTNSVAKEKSGNISGDEYLSQEEEVFDGNDIENNETKVYEESLDLDLERSNRQVWLVRLPMFLAEKWRDRNNLHGQELGKIRINKDGSKITLLLNENDNDSIPHEYDLELTKKVVENEYVFTEQNLKKYQQRKKELEADPEKQRQAYLKKQEREEELKKKQQQQKRRNNRKKFNHRVMTDRDGRDRYIPYVKTIPKKTAIVGTVCHECQVMPSMNDPNYHKIVEQRRNIVKLNNKERITTLDETVGVTMSHTGMSMRSDNSNFLKVGREKAKSNIKSIRMPKKEILDYLFKLFDEYDYWSLKGLKERTRQPEAHLKECLDKVATLVKKGPYAFKYTLRPEYKKLKEEERKATLGELADEQTGSAGDNAQGDAEADLEDEIEMEDVV

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 26 Entity 26 polymer

Description description	TEMPLATE DNA (209-MER)
Molecular weight formula_weight	64754.3 kDa
Source method src_method	syn
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	T

ATCGATGTATATATCTGACACGTGCCTGGAGACTAGGGAGTAATCCCCTTGGCGGTTAAAACGCGGGGGACAGCGCGTACGTGCGTTTAAGCGGTGCTAGAGCTGTCTACGACCAACACAGCGCAGAAGAGCTATGATATTTTTATGTATGTACAACACACATCGGAGGTGAATCGAACGTTCCATAGCTATTATATACACAGCGTGCT

Entity 27 Entity 27 polymer

Description description	Transcription initiation factor IIA large subunit
Molecular weight formula_weight	32230.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	U

MSNAEASRVYEIIVESVVNEVREDFENAGIDEQTLQDLKNIWQKKLTETKVTTFSWDNQFNEGNINGVQNDLNFNLATPGVNSSEFNIKEENTGNEGLILPNINSNNNIPHSGETNINTNTVEATNNSGATLNTNTSGNTNADVTSQPKIEVKPEIELTINNANITTVENIDDESEKKDDEEKEEDVEKTRKEKEQIEQVKLQAKKEKRSALLDTDEVGSELDDSDDDYLISEGEEDGPDENLMLCLYDKVTRTKARWKCSLKDGVVTINRNDYTFQKAQVEAEWV

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 28 Entity 28 polymer

Description description	Transcription initiation factor IIA subunit 2
Molecular weight formula_weight	13473.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	V

MAVPGYYELYRRSTIGNSLVDALDTLISDGRIEASLAMRVLETFDKVVAETLKDNTQSKLTVKGNLDTYGFCDDVWTFIVKNCQVTVEDSHRDASQNGSGDSQSVISVDKLRIVACNSKKSE

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 29 Entity 29 polymer

Description description	Transcription initiation factor IIE subunit alpha
Molecular weight formula_weight	55951.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	W

MDRPIDDIVKNLLKFVVRGFYGGSFVLVLDAILFHSVLAEDDLKQLLSINKTELGPLIARLRSDRLISIHKQREYPPNSKSVERVYYYVKYPHAIDAIKWKVHQVVQRLKDDLDKNSEPNGYMCPICLTKYTQLEAVQLLNFDRTEFLCSLCDEPLVEDDSGKKNKEKQDKLNRLMDQIQPIIDSLKKIDDSRIEENTFEIALARLIPPQNQSHAAYTYNPKKGSTMFRPGDSAPLPNLMGTALGNDSSRRAGANSQATLHINITTASDEVAQRELQERQAEEKRKQNAVPEWHKQSTIGKTALGRLDNEEEFDPVVTASAMDSINPDNEPAQETSYQNNRTLTEQEMEERENEKTLNDYYAALAKKQAKLNKEEEEEEEEEEDEEEEEEEEMEDVMDDNDETARENALEDEFEDVTDTAGTAKTESNTSNDVKQESINDKTEDAVNATATASGPSANAKPNDGDDDDDDDDDEMDIEFEDVAAALEHHHHH

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 30 Entity 30 polymer

Description description	Transcription initiation factor IIE subunit beta
Molecular weight formula_weight	37050.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	X

MSKNRDPLLANLNAFKSKVKSAPVIAPAKVGQKKTNDTVITIDGNTRKRTASERAQENTLNSAKNPVLVDIKKEAGSNSSNAISLDDDDDDEDFGSSPSKKVRPGSIAAAALQANQTDISKSHDSSKLLWATEYIQKKGKPVLVNELLDYLSMKKDDKVIELLKKLDRIEFDPKKGTFKYLSTYDVHSPSELLKLLRSQVTFKGISCKDLKDGWPQCDETINQLEEDSKILVLRTKKDKTPRYVWYNSGGNLKCIDEEFVKMWENVQLPQFAELPRKLQDLGLKPASVDPATIKRQTKRVEVKKKRQRKGKITNTHMTGILKDYSHRV

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 31 Entity 31 polymer

Description description	Mediator of RNA polymerase II transcription subunit 6
Molecular weight formula_weight	32844.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	a

MNVTPLDELQWKSPEWIQVFGLRTENVLDYFAESPFFDKTSNNQVIKMQRQFSQLNDPNAAVNMTQNIMTLPDGKNGNLEEEFAYVDPARRQILFKYPMYMQLEEELMKLDGTEYVLSSVREPDFWVIRKQRRTNNSGVGSAKGPEIIPLQDYYIIGANIYQSPTIFKIVQSRLMSTSYHLNSTLESLYDLIEFQPSQGVHYKVPTDTSTTATAATNGNNAGGGSNKSSVRPTGGANMATVPSTTNVNMTVNTMGTGGQTIDNGTGRTGNGNMGITTEMLDKLMVTSIRSTPNYI

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 32 Entity 32 polymer

Description description	Mediator of RNA polymerase II transcription subunit 8
Molecular weight formula_weight	25297.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	b

MSQSTASLVPEGNQGSLQEDVSFDFNGVPGQALDAVRMRLAQLTHSLRRIRDEMSKAELPQWYTLQSQLNVTLSQLVSVTSTLQHFQETLDSTVVYPLPKFPTTSHESLVTTLLRKKNIPEVDEWMKYVRETSGVTTALLKDEEIEKLLQQDREITNWARTTFRNEYGKHDFKNEESLSEEHASLLVRDSKPSKPFNVDDVLKFTFTGEKPIITGSTSTSSSN

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 33 Entity 33 polymer

Description description	Mediator of RNA polymerase II transcription subunit 11
Molecular weight formula_weight	13324.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	c

MQPPYIQERLKSLNDIETQLCSMLQEASQVTFIFGELKRGNESVKPQFENHVKQFYERLDKSTTQLRKEIQLLDENVGTRLLPINVNKKALGQDTEKMEEQLDLLSAILDPSKSK

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 34 Entity 34 polymer

Description description	Mediator of RNA polymerase II transcription subunit 17
Molecular weight formula_weight	78582.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	d

MTTEDPDSNHLSSETGIKLALDPNLITLALSSNPNSSLHSPTSDEPVPESAGKADTSIRLEGDELENKTKKDNDKNLKFLKNKDSLVSNPHEIYGSMPLEQLIPIILRQRGPGFKFVDLNEKELQNEIKQLGSDSSDGHNSEKKDTDGADENVQIGEDFMEVDYEDKDNPVDSRNETDHKTNENGETDDNIETVMTQEQFVKRRRDMLEHINLAMNESSLALEFVSLLLSSVKESTGMSSMSPFLRKVVKPSSLNSDKIPYVAPTKKEYIELDILNKGWKLQSLNESKDLLRASFNKLSSILQNEHDYWNKIMQSISNKDVIFKIRDRTSGQKLLAIKYGYEDSGSTYKHDRGIANIRNNIESQNLDLIPHSSSVFKGTDFVHSVKKFLRVRIFTKIESEDDYILSGESVMDRDSESEEAETKDIRKQIQLLKKIIFEKELMYQIKKECALLISYGVSIENENKVIIELPNEKFEIELLSLDDDSIVNHEQDLPKINDKRANLMLVMLRLLLVVIFKKTLRSRISSPHGLINLNVDDDILIIRPILGKVRFANYKLLLKKIIKDYVLDIVPGSSITETEVEREQPQENKNIDDENITKLNKEIRAFDKLLNIPRRELKINLPLTEHKSPNLSLMLESPNYCNALIHIKFSAGTEANAVSFDTTFSDFKEVEDFLHFIVAEYIQQKKV

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 35 Entity 35 polymer

Description description	Mediator of RNA polymerase II transcription subunit 18
Molecular weight formula_weight	34316.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	e

MVQQLSLFGSIGDDGYDLLISTLTTISGNPPLLYNSLCTVWKPNPSYDVENVNSRNQLVEPNRIKLSKEVPFSYLIDETMMDKPLNFRILKSFTNDKIPLNYAMTRNILHNTVPQVTNFNSTNEDQNNSKHTEDTVNESRNSDDIIDVDMDASPAPSNESCSPWSLQISDIPAAGNNRSVSMQTIAETIILSSAGKNSSVSSLMNGLGYVFEFQYLTIGVKFFMKHGLILELQKIWQIEEAGNSQITSGGFLLKAYINVSRGTDIDRINYTETALMNLKKELQGYIELSVPDRQSMDSRVAHGNILI

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 36 Entity 36 polymer

Description description	Mediator of RNA polymerase II transcription subunit 20
Molecular weight formula_weight	22918.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	f

MGKSAVIFVERATPATLTELKDALSNSILSVRDPWSIDFRTYRCSIKNLPADVSKLMYSITFHHHGRQTVLIKDNSAMVTTAAAADIPPALVFNGSSTGVPESIDTILSSKLSNIWMQRQLIKGDAGETLILDGLTVRLVNLFSSTGFKGLLIELQADEAGEFETKIAGIEGHLAEIRAKEYKTSSDSLGPDTSNEICDLAYQYVRALEL

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 37 Entity 37 polymer

Description description	Mediator of RNA polymerase II transcription subunit 22
Molecular weight formula_weight	13875.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	g

MSNQALYEKLEQTRTILSVKLAELINMTTIADRNDDDEGSFAQENSELAVATTSVMMVNNQTMQLIKNVQDLLILTRSIKEKWLLNQIPVTEHSKVTRFDEKQIEELLDNCIETFVAEKTT

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 38 Entity 38 polymer

Description description	Mediator of RNA polymerase II transcription subunit 4
Molecular weight formula_weight	32244.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	h

MSVQDTKAVEFSMGHIRSSSVSLVAEATSNTNSEDKLSKVQLYEDLCRYEDTLSKLVESVDRFKPNLDIAKDLIRTDEALFENVKLLAEYDNIYRNLQKIDKDSEELDSKTRKILEILNECHDELKALPMLEQVEFEKNTILQQRSKINSTELLDYATKLSKFTKIPPTFDKGAVGPNNFIWPAEDALRRGMLAMASLHSKELTRIPGEEVEETEVPTVPPSQSEEQKGQMAKKEGTPKTDSFIFDGTAKEVGDEADNTKDKEKEENNDDALDLDLDLFDPDDF

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 39 Entity 39 polymer

Description description	Mediator of RNA polymerase II transcription subunit 7
Molecular weight formula_weight	25616.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	i

MSNDPGNEVSSLYPPPPPYVKFFTQSNLEKLPKYKEKKAASAKQTAPNNSNGGSEEEITCALDYLIPPPMPKNQQYRAFGSIWQVKDQLPDLESMGLTQLYKKSTENESTNYQYKIQELRKLLKSLLLNYLELIGVLSINPDMYERKVENIRTILVNIHHLLNEYRPHQSRESLIMLLEEQLEYKRGEIREIEQVCKQVHDKLTSIQDTLRTGSQSPPSSSQ

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 40 Entity 40 polymer

Description description	Mediator of RNA polymerase II transcription subunit 9
Molecular weight formula_weight	17400.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	j

MNLQNNVLNQIHQILLPTNPTLDKPNAEATKEEFSSAENRDEKDYLTNQQPKNLSTPSTSSNGEFIPHIFYSLHQIRKDPNNLSNQLETLTGSIRHRLKLCKSLISENEDTKDLLSKSPSEWQDIIHQREQELQIKRDVLDDLYRKLQR

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 41 Entity 41 polymer

Description description	Mediator of RNA polymerase II transcription subunit 10
Molecular weight formula_weight	17927.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	k

MNGNSTNNEQLQQELATTQDQVASIIESFVELGVSIYDFPGTPEATKGMITNLQRNVDRLYKLNVRSNDPQSSLSKVDIPLEVVQYIEDGRNPDIYTREFVEAIRRSNQYQRGKMHGLKQLRDSLADKIVDEFPELKEPVEDIIKRTSPIDNVSNTH

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 42 Entity 42 polymer

Description description	Mediator of RNA polymerase II transcription subunit 14
Molecular weight formula_weight	84746.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	l

MTTTIGSPQMLANEERLSNEMHALKNRSEQNGQEQQGPVKNTQLHGPSATDPETTATQKESLEMVPKDTSAATMTSAPPPALPHVEINQVSLALVIRNLTVFTMKELAQYMKTNVHTQANEPNSAKKIRFLQLIIFLRTQFLKLYVLVKWTRTIKQNNFHVLIDLLNWFRTTNMNVNNCIWALKSSLNSMTNAKLPNVDLVTALEVLSLGRPNLPTHNFKLSGVSNSMDMVDGMAKVPIGLILQRLKDLNLTVSIKIALMNIPKPLNSYHIKNGRIYFTVPNEFEIQLSTVNRQSPLFFVDLKLLFNTEAEQTVSAVTEATSTNGDSENNEENSSSNGNNLPLNKPRLEKLINEILLKSNDPLLSLYNFLHKYVLTLQLYMVHREFLKLANGGKFSKSNLIHNYDSKKSTITVRYWLNGKMDSKGKITIGIQRTTESLILKWDNQSASRAKNMPVIYNNIVSNIEGILDEIMFNHARIIRSELLARDIFQEDEENSDVLLFQLPTTCVSMAPIQLKIDLLSGQFYFRNPTPLLSNYASKINRAEGPEELARILQQLKLDKIIHVLTTMFENTGWSCSRIIKIDKPIRTQVNTGGESVVKKEDNKYAIAGNSTTNSDVSLLLQRDLFIRLPHWPLNWYLILSIISSKTSCVVEKRIGKIVSQRGKWNLKYLDNSNVMTVKLESITYQKIMILQRTILNRIINHMLIDSLNQLEIRNKICSSEMINEQKLPQYIIQGSNTNDNISII

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 43 Entity 43 polymer

Description description	Mediator of RNA polymerase II transcription subunit 19
Molecular weight formula_weight	24885.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	m

MASRVDETTVPSYYYYVDPETTYTYQQPNPLQDLISVYGLDDISRQVARTNLDGTKAVKLRKSYKNQIADLSGKFSTIPTRENGKGGQIAHILFQNNPDMMIQPPQQGQNMSEQQWREQLRNRDIALFQPPNFDWDLCSSVLSQFERSYPSEFANQNQGGAQAPFDIDDLAFDLDGTGKSQSGSNSGNNSKKRKNKSSGSSMATPTHSDSHEDMKRRRLE

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 44 Entity 44 polymer

Description description	Mediator of RNA polymerase II transcription subunit 21
Molecular weight formula_weight	16093.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	n

MTDRLTQLQICLDQMTEQFCATLNYIDKNHGFERLTVNEPQMSDKHATVVPPEEFSNTIDELSTDIILKTRQINKLIDSLPGVDVSAEEQLRKIDMLQKKLVEVEDEKIEAIKKKEKLLRHVDSLIEDFVDGIANSKKST

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 45 Entity 45 polymer

Description description	Mediator of RNA polymerase II transcription subunit 31
Molecular weight formula_weight	14747.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	o

MSSTNGNAPATPSSDQNPLPTRFEVELEFIQSLANIQYVTYLLTQQQIWKSPNFKNYLKYLEYWCNPPYSQCIVYPNCLFILKLLNGFMESAIVNEDGLLEGLDELPKIIQLQGPQWMNEMVERWAN

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 46 Entity 46 polymer

Description description	Mediator of RNA polymerase II transcription subunit 1
Molecular weight formula_weight	64315.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	p

MVEGDSYVETLDSMIELFKDYKPGSITLENITRLCQTLGLESFTEELSNELSRLSTASKIIVIDVDYNKKQDRIQDVKLVLASNFDNFDYFNQRDGEHEKSNILLNSLTKYPDLKAFHNNLKFLYLLDAYSHIESDSTSHNNGSSDKSLDSSNASFNNQGKLDLFKYFTELSHYIRQCFQDNCCDFKVRTNLNDKFGIYILTQGINGKEVPLAKIYLEENKSDSQYRFYEYIYSQETKSWINESAENFSNGISLVMEIVANAKESNYTDLIWFPEDFISPELIIDKVTCSSNSSSSPPIIDLFSNNNYNSRIQLMNDFTTKLINIKKFDISNDNLDLISEILKWVQWSRIVLQNVFKLVSTPSSNSNSSELEPDYQAPFSTSTKDKNSSTSNTEPIPRSNRHGSVVEASRRRRSSTNKSKRPSITEAMMLKEEGLQQFNLHEILSEPAIEEENGDSIKEHSTTMDGANDLGFTASVSNQENAGTDIVMEDHGVLQGTSQNYGTATADDADIEMKDVSSKPSKPESSVLQLIVSEDHIILDTISECNLYDDVKCWSKFIEKFQDIVS

Source Source

Source organism organism	Saccharomyces cerevisiae
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli

Entity 47 Entity 47 non-polymer

Description description	IRON/SULFUR CLUSTER
Molecular weight formula_weight	351.6 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 48 Entity 48 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	17

Entity 49 Entity 49 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	1

▶

Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	3.00 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	186599

Yeast RNA polymerase II transcription pre-initiation complex with core Mediator

1. Protein Identity and Related Structures Protein Identity & Related Structures

General transcription and DNA repair factor IIH helicase subunit XPD

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

General transcription and DNA repair factor IIH helicase subunit XPB

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerase II subunit RPB1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerase II subunit RPB2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerase II subunit RPB3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerase II subunit RPB4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerases I, II, and III subunit RPABC1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerases I, II, and III subunit RPABC2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerase II subunit RPB7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerases I, II, and III subunit RPABC3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer