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1a5w

ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

INTEGRASE

Rous sarcoma virus (strain Schmidt-Ruppin)

UniProt P03354

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 4-ACETYLAMINO-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
5kz9 5kza 5kzb 6ccj 6ce5 6cus 6cv8 6cw4

8 assemblies

Homodimer
1a5v 1a5v 1a5w 1a5x 1asu 1asv 1asw 1c0m 1c0m 1c1a 1cxq 1cxu

26 assemblies; showing the first 12

Homotetramer
5kz9 5kzb

2 assemblies

Other homooligomers
3tir

1 assemblies

Heteromeric or nucleic-acid complex
5ejk 7jn3 7ku7 7kui 8e14

5 assemblies

View Construct and Data Evidence
UniProt name POL_RSVP
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–156； UniProt 624–779

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1a5w
Deposition date deposition_date1998-02-18
Structure title titleASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3
Keywords keywordsHYDROLASE, ENDONUCLEASE, HIV-1 INTEGRASE INHIBITOR; HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1a5w__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1a5w__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1a5w__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）23.55 Å
Rg (electron density)23.28 Å
Total Rg24.03 Å
Atom count2294
Residues292
Excluded volume40732 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1a5w__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd1a5wa_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.3 — Ribonuclease H-like
Family Family familyc.55.3.2 — Retroviral integrase, catalytic domain

CATH v4.4 (1 domains)

Domain ID domain_id1a5wA00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily10 — Ribonuclease H-like superfamily/Ribonuclease H
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7. Citations (1)