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3wtv

Crystal structure of the complex comprised of ETS1(V170G), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Runt-related transcription factor 1

Mus musculus

UniProt Q03347

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 3 DNA 2 Core-binding factor subunit beta × 1 （Q08024） Protein C-ets-1 × 1 （P14921） ;DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3') ; × 1 ;DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3') ; × 1 water × 1 Consistent with all polymers
2 Protein–DNA Heteromer Protein 3 DNA 2 Core-binding factor subunit beta × 1 （Q08024） Protein C-ets-1 × 1 （P14921） ;DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3') ; × 1 ;DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3') ; × 1 water × 3 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
1ean 1eao 1eao 1eaq 1eaq 2j6w 2j6w

7 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1hjb 1hjb 1hjc 1hjc 1io4 3wts 3wts 3wtt 3wtt 3wtu 3wtu 3wtv

24 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RUNX1_MOUSE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–204； UniProt 60–263 Author chain F； PDBConstruct 1–204； UniProt 60–263

Core-binding factor subunit beta

Mus musculus

UniProt Q08024

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 3 DNA 2 Runt-related transcription factor 1 × 1 （Q03347） Protein C-ets-1 × 1 （P14921） ;DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3') ; × 1 ;DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3') ; × 1 water × 1 Consistent with all polymers
2 Protein–DNA Heteromer Protein 3 DNA 2 Runt-related transcription factor 1 × 1 （Q03347） Protein C-ets-1 × 1 （P14921） ;DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3') ; × 1 ;DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3') ; × 1 water × 3 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
1ilf 2jhb

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1io4 3wts 3wts 3wtt 3wtt 3wtu 3wtu 3wtv 3wtv 3wtw 3wtw 3wtx

15 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name PEBB_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–142； UniProt 1–142 Author chain G； PDBConstruct 1–142； UniProt 1–142

Protein C-ets-1

Homo sapiens

UniProt P14921

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 3 DNA 2 Runt-related transcription factor 1 × 1 （Q03347） Core-binding factor subunit beta × 1 （Q08024） ;DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3') ; × 1 ;DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3') ; × 1 water × 1 Consistent with all polymers
2 Protein–DNA Heteromer Protein 3 DNA 2 Runt-related transcription factor 1 × 1 （Q03347） Core-binding factor subunit beta × 1 （Q08024） ;DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3') ; × 1 ;DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3') ; × 1 water × 3 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1gvj 3wtz 3wu0

3 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2nny 2stt 2stw 3mfk 3ri4 3wts 3wts 3wtt 3wtt 3wtu 3wtu 3wtv

26 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ETS1_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–166； UniProt 276–441 Author chain H； PDBConstruct 1–166； UniProt 276–441

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3wtv
Deposition date deposition_date2014-04-21
Structure title titleCrystal structure of the complex comprised of ETS1(V170G), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA
Keywords keywords;PROTEIN-DNA COMPLEX, TRANSCRIPTION, DNA-BINDING, METHYLATION, NUCLEUS, PHOSPHOPROTEIN, TRANSCRIPTION REGULATION, ISOPEPTIDE BOND, PROTO-ONCOGENE, TRANSCRIPTION-DNA COMPLEX ;; TRANSCRIPTION/DNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3wtv__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3wtv__assembly_2__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3wtv__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）26.89 Å
Rg (electron density)26.79 Å
Total Rg27.39 Å
Atom count3435
Residues378
Excluded volume58963 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3wtv__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 3wtv__assembly_2__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 11 domains

SCOP 2.08 (5 domains)

Domain ID domain_idd3wtva_
Class classb — All beta proteins
Fold Fold foldb.2 — Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily Superfamily superfamilyb.2.5 — p53-like transcription factors
Family Family familyb.2.5.6 — RUNT domain
Domain ID domain_idd3wtvb_
Class classb — All beta proteins
Fold Fold foldb.54 — Core binding factor beta, CBF
Superfamily Superfamily superfamilyb.54.1 — Core binding factor beta, CBF
Family Family familyb.54.1.1 — Core binding factor beta, CBF
Domain ID domain_idd3wtvc_
Class classa — All alpha proteins
Fold Fold folda.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamilya.4.5 — 'Winged helix' DNA-binding domain
Family Family familya.4.5.21 — ets domain
Domain ID domain_idd3wtvf_
Class classb — All beta proteins
Fold Fold foldb.2 — Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily Superfamily superfamilyb.2.5 — p53-like transcription factors
Family Family familyb.2.5.6 — RUNT domain
Domain ID domain_idd3wtvg_
Class classb — All beta proteins
Fold Fold foldb.54 — Core binding factor beta, CBF
Superfamily Superfamily superfamilyb.54.1 — Core binding factor beta, CBF
Family Family familyb.54.1.1 — Core binding factor beta, CBF

CATH v4.4 (6 domains)

Domain ID domain_id3wtvA00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily720 —
Domain ID domain_id3wtvB00
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology250 — Polyomavirus Enhancer Binding Protein 2; Chain: A;
Homologous superfamily homologous superfamily10 — Core binding factor, beta subunit
Domain ID domain_id3wtvC00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily10 — Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Domain ID domain_id3wtvF00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily720 —
Domain ID domain_id3wtvG00
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology250 — Polyomavirus Enhancer Binding Protein 2; Chain: A;
Homologous superfamily homologous superfamily10 — Core binding factor, beta subunit
Domain ID domain_id3wtvH00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily10 — Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
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7. Citations (1)