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4jgh

Structure of the SOCS2-Elongin BC complex bound to an N-terminal fragment of Cullin5

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Suppressor of cytokine signaling 2

Homo sapiens

UniProt O14508

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Transcription elongation factor B polypeptide 2 × 1 （P62869） Transcription elongation factor B polypeptide 1 × 1 （P83940） Cullin-5 × 1 （Q93034） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 Transcription elongation factor B polypeptide 2 × 1 （P62869） Transcription elongation factor B polypeptide 1 × 1 （P83940） Cullin-5 × 1 （Q93034） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2c9w 4jgh 4jgh 5bo4 5bo4 5bo4 5bo4 5bo4 5bo4 6i4x 6i5j 6i5j

27 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name SOCS2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 7–173； UniProt 32–198

Transcription elongation factor B polypeptide 2

Mus musculus

UniProt P62869

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Suppressor of cytokine signaling 2 × 1 （O14508） Transcription elongation factor B polypeptide 1 × 1 （P83940） Cullin-5 × 1 （Q93034） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 Suppressor of cytokine signaling 2 × 1 （O14508） Transcription elongation factor B polypeptide 1 × 1 （P83940） Cullin-5 × 1 （Q93034） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2fnj 4jgh 4jgh 9rp9

4 assemblies

View Construct and Data Evidence
UniProt name ELOB_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–118； UniProt 1–118

Transcription elongation factor B polypeptide 1

Mus musculus

UniProt P83940

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Suppressor of cytokine signaling 2 × 1 （O14508） Transcription elongation factor B polypeptide 2 × 1 （P62869） Cullin-5 × 1 （Q93034） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 Suppressor of cytokine signaling 2 × 1 （O14508） Transcription elongation factor B polypeptide 2 × 1 （P62869） Cullin-5 × 1 （Q93034） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2fnj 2jz3 4jgh 4jgh 9rp9

5 assemblies

View Construct and Data Evidence
UniProt name ELOC_MOUSE
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–96； UniProt 17–112

Cullin-5

Homo sapiens

UniProt Q93034

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Suppressor of cytokine signaling 2 × 1 （O14508） Transcription elongation factor B polypeptide 2 × 1 （P62869） Transcription elongation factor B polypeptide 1 × 1 （P83940） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 Suppressor of cytokine signaling 2 × 1 （O14508） Transcription elongation factor B polypeptide 2 × 1 （P62869） Transcription elongation factor B polypeptide 1 × 1 （P83940） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3dpl 3dqv 3dqv 3dqv 4jgh 4jgh 4n9f 4n9f 4n9f 4n9f 4n9f 4n9f

28 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CUL5_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain D； PDBConstruct 1–377； UniProt 10–386

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4jgh
Deposition date deposition_date2013-03-01
Structure title titleStructure of the SOCS2-Elongin BC complex bound to an N-terminal fragment of Cullin5
Keywords keywordsCullin-RING E3 ubiquitin ligases, Ubiquitination, Cytosol, ligase; LIGASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4jgh__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4jgh__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4jgh__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）38.62 Å
Rg (electron density)38.23 Å
Total Rg38.63 Å
Atom count5902
Residues731
Excluded volume105630 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4jgh__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4jgh__assembly_2__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 14 domains

SCOP 2.08 (7 domains)

Domain ID domain_idd4jgha1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.93 — SH2-like
Superfamily Superfamily superfamilyd.93.1 — SH2 domain
Family Family familyd.93.1.1 — SH2 domain
Domain ID domain_idd4jgha2
Class classa — All alpha proteins
Fold Fold folda.271 — SOCS box-like
Superfamily Superfamily superfamilya.271.1 — SOCS box-like
Family Family familya.271.1.0 — automated matches
Domain ID domain_idd4jgha3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd4jghb_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.15 — beta-Grasp (ubiquitin-like)
Superfamily Superfamily superfamilyd.15.1 — Ubiquitin-like
Family Family familyd.15.1.1 — Ubiquitin-related
Domain ID domain_idd4jghc_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.42 — POZ domain
Superfamily Superfamily superfamilyd.42.1 — POZ domain
Family Family familyd.42.1.1 — BTB/POZ domain
Domain ID domain_idd4jghd1
Class classa — All alpha proteins
Fold Fold folda.118 — alpha-alpha superhelix
Superfamily Superfamily superfamilya.118.17 — Cullin repeat-like
Family Family familya.118.17.0 — automated matches
Domain ID domain_idd4jghd2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags

CATH v4.4 (7 domains)

Domain ID domain_id4jghA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology505 — SHC Adaptor Protein
Homologous superfamily homologous superfamily10 — SH2 domain
Domain ID domain_id4jghA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology750 — Elongin C; Chain C, domain 1
Homologous superfamily homologous superfamily20 — SOCS box
Domain ID domain_id4jghB00
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily90 — Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Domain ID domain_id4jghC00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology710 — Potassium Channel Kv1.1; Chain A
Homologous superfamily homologous superfamily10 — Potassium Channel Kv1.1; Chain A
Domain ID domain_id4jghD01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1310 — 5 helical Cullin repeat like
Homologous superfamily homologous superfamily10 — Cullin Repeats
Domain ID domain_id4jghD02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1310 — 5 helical Cullin repeat like
Homologous superfamily homologous superfamily10 — Cullin Repeats
Domain ID domain_id4jghD03
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1310 — 5 helical Cullin repeat like
Homologous superfamily homologous superfamily10 — Cullin Repeats
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7. Citations (1)