5fj9

Cryo-EM structure of yeast apo RNA polymerase III at 4.6 A

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC1_YEAST
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–1460； UniProt 1–1460

DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2

OrganismNot specified

UniProt P22276

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC2_YEAST
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–1149； UniProt 1–1149

DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1

OrganismNot specified

UniProt P07703

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAC1_YEAST
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–335； UniProt 1–335

DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9

OrganismNot specified

UniProt P47076

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC9_YEAST
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–161； UniProt 1–161

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1

OrganismNot specified

UniProt P20434

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB1_YEAST
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–215； UniProt 1–215

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2

OrganismNot specified

UniProt P20435

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB2_YEAST
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–155； UniProt 1–155

DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8

OrganismNot specified

UniProt P35718

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC8_YEAST
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–212； UniProt 1–212

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3

OrganismNot specified

UniProt P20436

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB3_YEAST
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain H； PDBConstruct 1–146； UniProt 1–146

DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10

OrganismNot specified

UniProt Q04307

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC10_YEAST
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain I； PDBConstruct 1–110； UniProt 1–110

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5

OrganismNot specified

UniProt P22139

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB5_YEAST
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain J； PDBConstruct 1–70； UniProt 1–70

DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2

OrganismNot specified

UniProt P28000

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAC2_YEAST
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain K； PDBConstruct 1–142； UniProt 1–142

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4

OrganismNot specified

UniProt P40422

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB4_YEAST
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain L； PDBConstruct 1–70； UniProt 1–70

DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5

OrganismNot specified

UniProt P36121

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC5_YEAST
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain M； PDBConstruct 1–282； UniProt 1–282

DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4

OrganismNot specified

UniProt P25441

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC4_YEAST
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain N； PDBConstruct 1–422； UniProt 1–422

DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3

OrganismNot specified

UniProt P32349

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC3_YEAST
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain O； PDBConstruct 1–654； UniProt 1–654

DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6

OrganismNot specified

UniProt P32910

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 × 1 （P17890） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC6_YEAST
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain P； PDBConstruct 1–317； UniProt 1–317

DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7

OrganismNot specified

UniProt P17890

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 × 1 （P04051） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 × 1 （P22276） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 × 1 （P07703） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 × 1 （P47076） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 × 1 （P20434） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 × 1 （P20435） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 × 1 （P35718） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 × 1 （P20436） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 × 1 （Q04307） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 × 1 （P22139） DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 × 1 （P28000） DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 × 1 （P40422） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 × 1 （P36121） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 × 1 （P25441） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 × 1 （P32349） DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 × 1 （P32910） ZINC ION × 6	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC7_YEAST
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain Q； PDBConstruct 1–69； UniProt 1–69

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	5fj9
Deposition date deposition_date	2015-10-06
Structure title title	Cryo-EM structure of yeast apo RNA polymerase III at 4.6 A
Keywords keywords	RNA POLYMERASE III, POL III, TRANSCRIPTION, RNA POLYMERASE; TRANSCRIPTION
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5fj9__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5fj9__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

5fj9__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	59.34 Å
Rg (electron density)	59.00 Å
Total Rg	59.06 Å
Atom count	38680
Residues	4880
Excluded volume	692200 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`5fj9__assembly_1__model_1`	heptadecameric （17）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (18)

Entity 1 Entity 1 polymer

Description description	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1
Molecular weight formula_weight	162517.8 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A
Atom count atom_count	38680

MKEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKANGALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQRRCLHCGALNGVVKKAAAGAGSAALKIIHDTFRWVGKKSAPEKDIWVGEWKEVLAHNPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSGRPETYIWRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIKAGLDKGISINNMMEHWDYLQLTVAMYINSDSVNPAMLPGSSNGGGKVKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEKVTRYNRHKLQELIVNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVVERHLEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTPYNADFDGDEMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDFITGSYLISHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTGKQVFSLLIKPNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQILSGVMDKSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSIGINDVTPADDLKQKKEELVEIAYHKCDELITLFNKGELETQPGCNEEQTLEAKIGGLLSKVREEVGDVCINELDNWNAPLIMATCGSKGSTLNVSQMVAVVGQQIISGNRVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGLSPPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRTSANGIVQFTYGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPYAIMETANEILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHSLREYINGKATALANLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRISEKSVRKFLEIALFKYRKARLEPGTAIGAIGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINASKVISTPIINAVLVNDNDERAARVVKGRVEKTLLSDVAFYVQDVYKDNLSFIQVRIDLGTIDKLQLELTIEDIAVAITRASKLKIQASDVNIIGKDRIAINVFPEGYKAKSISTSAKEPSENDVFYRMQQLRRALPDVVVKGLPDISRAVINIRDDGKRELLVEGYGLRDVMCTDGVIGSRTTTNHVLEVFSVLGIEAARYSIIREINYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMRDSVLQLASFEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMSIGTGSFKVVKGTNISEKDLVPKRCLFESLSNEAALKAN

Entity 2 Entity 2 polymer

Description description	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2
Molecular weight formula_weight	129629.4 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MVAATKRRKTHIHKHVKDEAFDDLLKPVYKGKKLTDEINTAQDKWHLLPAFLKVKGLVKQHLDSFNYFVDTDLKKIIKANQLILSDVDPEFYLKYVDIRVGKKSSSSTKDYLTPPHECRLRDMTYSAPIYVDIEYTRGRNIIMHKDVEIGRMPIMLRSNKCILYDADESKMAKLNECPLDPGGYFIVNGTEKVILVQEQLSKNRIIVEADEKKGIVQASVTSSTHERKSKTYVITKNGKIYLKHNSIAEEIPIAIVLKACGILSDLEIMQLVCGNDSSYQDIFAVNLEESSKLDIYTQQQALEYIGAKVKTMRRQKLTILQEGIEAIATTVIAHLTVEALDFREKALYIAMMTRRVVMAMYNPKMIDDRDYVGNKRLELAGQLISLLFEDLFKKFNNDFKLSIDKVLKKPNRAMEYDALLSINVHSNNITSGLNRAISTGNWSLKRFKMERAGVTHVLSRLSYISALGMMTRISSQFEKSRKVSGPRALQPSQFGMLCTADTPEGEACGLVKNLALMTHITTDDEEEPIKKLCYVLGVEDITLIDSASLHLNYGVYLNGTLIGSIRFPTKFVTQFRHLRRTGKVSEFISIYSNSHQMAVHIATDGGRICRPLIIVSDGQSRVKDIHLRKLLDGELDFDDFLKLGLVEYLDVNEENDSYIALYEKDIVPSMTHLEIEPFTILGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIAYNQFKRIDTLLYLMTYPQQPMVKTKTIELIDYDKLPAGQNATVAVMSYSGYDIEDALVLNKSSIDRGFGRCETRRKTTTVLKRYANHTQDIIGGMRVDENGDPIWQHQSLGPDGLGEVGMKVQSGQIYINKSVPTNSADAPNPNNVNVQTQYREAPVIYRGPEPSHIDQVMMSVSDNDQALIKVLLRQNRRPELGDKFSSRHGQKGVCGIIVKQEDMPFNDQGIVPDIIMNPHGFPSRMTVGKMIELISGKAGVLNGTLEYGTCFGGSKLEDMSKILVDQGFNYSGKDMLYSGITGECLQAYIFFGPIYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCVIAYGASQLLLERLMISSDAFEVDVCDKCGLMGYSGWCTTCKSAENIIKMTIPYAAKLLFQELLSMNIAPRLRLEDIFQQ

Entity 3 Entity 3 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1
Molecular weight formula_weight	37732.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINIDTSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNLPDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFADCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIKGESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIFNVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Entity 4 Entity 4 polymer

Description description	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9
Molecular weight formula_weight	18623.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MKVLEERNAFLSDYEVLKFLTDLEKKHLWDQKSLAALKKSRSKGKQNRPYNHPELQGITRNVVNYLSINKNFINQEDEGEERESSGAKDAEKSGISKMSDESFAELMTKLNSFKLFKAEKLQIVNQLPANMVHLYSIVEECDARFDEKTIEEMLEIISGYA

Entity 5 Entity 5 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1
Molecular weight formula_weight	25117.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Entity 6 Entity 6 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2
Molecular weight formula_weight	17931.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQHEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Entity 7 Entity 7 polymer

Description description	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8
Molecular weight formula_weight	24349.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MFILSKIADLVRIPPDQFHRDTISAITHQLNNKFANKIIPNVGLCITIYDLLTVEEGQLKPGDGSSYINVTFRAVVFKPFLGEIVTGWISKCTAEGIKVSLLGIFDDIFIPQNMLFEGCYYTPEESAWIWPMDEETKLYFDVNEKIRFRIEREVFVDVKPKSPKERELEERAQLENEIEGKNEETPQNEKPPAYALLGSCQTDGMGLVSWWE

Entity 8 Entity 8 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3
Molecular weight formula_weight	16525.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIASSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGGLLMRLEGNYRNLNNLKQENAYLLIRR

Entity 9 Entity 9 polymer

Description description	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10
Molecular weight formula_weight	12525.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MLSFCPSCNNMLLITSGDSGVYTLACRSCPYEFPIEGIEIYDRKKLPRKEVDDVLGGGWDNVDQTKTQCPNYDTCGGESAYFFQLQIRSADEPMTTFYKCVNCGHRWKEN

Entity 10 Entity 10 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5
Molecular weight formula_weight	8290.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKFLRYNPLEKRD

Entity 11 Entity 11 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2
Molecular weight formula_weight	16167.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTSASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKGLKDLMDLCDVVESKFTEKIKSM

Entity 12 Entity 12 polymer

Description description	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4
Molecular weight formula_weight	7730.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR

Entity 13 Entity 13 polymer

Description description	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5
Molecular weight formula_weight	32178.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M

MSIDNKLFVTEEDEEDRTQDRADVEDESNDIDMIADENGTNSAIANEQEEKSEEVKAEDDTGEEEEDDPVIEEFPLKISGEEESLHVFQYANRPRLVGRKPAEHPFISAARYKPKSHLWEIDIPLDEQAFYNKDKAESEWNGVNVQTLKGVGVENNGQYAAFVKDMQVYLVPIERVAQLKPFFKYIDDANVTRKQEDARRNPNPSSQRAQVVTMSVKSVNDPSQNRLTGSLLAHKVADEEANIELTWAEGTFEQFKDTIVKEAEDKTLVALEKQEDYIDNLV

Entity 14 Entity 14 polymer

Description description	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4
Molecular weight formula_weight	46751.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N

MSSNKGNGRLPSLKDSSSNGGGSAKPSLKFKPKAVARKSKEEREAAASKVKLEEESKRGNDKKHFNNKNKRVTGAGGQQRRMAKYLNNTHVISSGPLAAGNFVSEKGDLRRGFIKSEGSGSSLVQKGLETIDNGAESSENEAEDDDNEGVASKSKKKFNMGKEFEARNLIEDEDDGESEKSSDVDMDDEEWRSKRIEQLFPVRPVRVRHEDVETVKREIQEALSEKPTREPTPSVKTEPVGTGLQSYLEERERQVNEKLADLGLEKEFQSVDGKEAAAELELLNADHQHILRKLKKMNNKPERFMVFQLPTRLPAFERPAVKEEKEDMETQASDPSKKKKNIKKKDTKDALSTRELAGKVGSIRVHKSGKLSVKIGNVVMDIGKGAETTFLQDVIALSIADDASSAELLGRVDGKIVVTPQI

Entity 15 Entity 15 polymer

Description description	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3
Molecular weight formula_weight	74112.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O

MDELLGEALSAENQTGESTVESEKLVTPEDVMTISSLEQRTLNPDLFLYKELVKAHLGERAASVIGMLVALGRLSVRELVEKIDGMDVDSVKTTLVSLTQLRCVKYLQETAISGKKTTYYYYNEEGIHILLYSGLIIDEIITQMRVNDEEEHKQLVAEIVQNVISLGSLTVEDYLSSVTSDSMKYTISSLFVQLCEMGYLIQISKLHYTPIEDLWQFLYEKHYKNIPRNSPLSDLKKRSQAKMNAKTDFAKIINKPNELSQILTVDPKTSLRIVKPTVSLTINLDRFMKGRRSKQLINLAKTRVGSVTAQVYKIALRLTEQKSPKIRDPLTQTGLLQDLEEAKSFQDEAELVEEKTPGLTFNAIDLARHLPAELDLRGSLLSRKPSDNKKRSGSNAAASLPSKKLKTEDGFVIPALPAAVSKSLQESGDTQEEDEEEEDLDADTEDPHSASLINSHLKILASSNFPFLNETKPGVYYVPYSKLMPVLKSSVYEYVIASTLGPSAMRLSRCIRDNKLVSEKIINSTALMKEKDIRSTLASLIRYNSVEIQEVPRTADRSASRAVFLFRCKETHSYNFMRQNLEWNMANLLFKKEKLKQENSTLLKKANRDDVKGRENELLLPSELNQLKMVNERELNVFARLSRLLSLWEVFQMA

Entity 16 Entity 16 polymer

Description description	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6
Molecular weight formula_weight	36174.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P

MSGMIENGLQLSDNAKTLHSQMMSKGIGALFTQQELQKQMGIGSLTDLMSIVQELLDKNLIKLVKQNDELKFQGVLESEAQKKATMSAEEALVYSYIEASGREGIWSKTIKARTNLHQHVVLKCLKSLESQRYVKSVKSVKFPTRKIYMLYSLQPSVDITGGPWFTDGELDIEFINSLLTIVWRFISENTFPNGFKNFENGPKKNVFYAPNVKNYSTTQEILEFITAAQVANVELTPSNIRSLCEVLVYDDKLEKVTHDCYRVTLESILQMNQGEGEPEAGNKALEDEEEFSIFNYFKMFPASKHDKEVVYFDEWTI

Entity 17 Entity 17 polymer

Description description	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7
Molecular weight formula_weight	10349.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

MSSYRGGSRGGGSNYMSNLPFGLGYGDVGKNHITEFPSIPLPINGPITNKERSLAVKYINFGKTVKDGPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

Entity 18 Entity 18 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	6

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	1

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	4.600 Å
Low-resolution limit resolution_low	— Å
R factor r_factor	—
R_work r_work	—
R_free r_free	—

Resolution resolution	4.60 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	68818

Cryo-EM structure of yeast apo RNA polymerase III at 4.6 A

1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer