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5iz7

Cryo-EM structure of thermally stable Zika virus strain H/PF/2013

Method: ELECTRON MICROSCOPY Dmax: 174.5 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

structural protein E

OrganismNot specified

UniProt A0A024B7W1

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 360 PDB declaration: 360-meric（360） Consistent with protein copy count Chain A； UniProt 291–794 Chain B； UniProt 291–794 Chain C； UniProt 291–794 Not recorded structural protein M × 180 （A0A0U4DG08） NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 180 ELECTRON MICROSCOPY cryo-EM buffer：pH 8 cryo-EM vitrification conditions：Cryogen ETHANE；blot for 1s Resolution 3.70 Å
2 Protein heterocomplex Heteromer Protein × 6 PDB declaration: hexameric（6） Consistent with protein copy count Chain A； UniProt 291–794 Chain B； UniProt 291–794 Chain C； UniProt 291–794 Not recorded structural protein M × 3 （A0A0U4DG08） NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ELECTRON MICROSCOPY cryo-EM buffer：pH 8 cryo-EM vitrification conditions：Cryogen ETHANE；blot for 1s Resolution 3.70 Å
3 Protein heterocomplex Heteromer Protein × 30 PDB declaration: 30-meric（30） Consistent with protein copy count Chain A； UniProt 291–794 Chain B； UniProt 291–794 Chain C； UniProt 291–794 Not recorded structural protein M × 15 （A0A0U4DG08） NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 ELECTRON MICROSCOPY cryo-EM buffer：pH 8 cryo-EM vitrification conditions：Cryogen ETHANE；blot for 1s Resolution 3.70 Å
4 Protein heterocomplex Heteromer Protein × 36 PDB declaration: 36-meric（36） Consistent with protein copy count Chain A； UniProt 291–794 Chain B； UniProt 291–794 Chain C； UniProt 291–794 Not recorded structural protein M × 18 （A0A0U4DG08） NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 ELECTRON MICROSCOPY cryo-EM buffer：pH 8 cryo-EM vitrification conditions：Cryogen ETHANE；blot for 1s Resolution 3.70 Å
5 Protein heterocomplex Heteromer Protein × 6 PDB declaration: hexameric（6） Consistent with protein copy count Chain A； UniProt 291–794 Chain B； UniProt 291–794 Chain C； UniProt 291–794 Not recorded structural protein M × 3 （A0A0U4DG08） NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ELECTRON MICROSCOPY cryo-EM buffer：pH 8 cryo-EM vitrification conditions：Cryogen ETHANE；blot for 1s Resolution 3.70 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 5IZ7 Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5GZR Zika virus E protein complexed with a neutralizing antibody Z23-Fab Deposited 2016-10-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 600 PDB declaration: 600-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；3 uL Zika virus-Z23 Fab complex sample was transferred onto a glow-discharged ultra-thin carbon-coated copper grid (Purchased from Zhongjingkeyi Company, China) followed by 60s waiting and blotted for 2s with filter paper before plugging into liquid ethane using the FEI Vitrobot Mark IV
Resolution 9.40 Å
5GZR Zika virus E protein complexed with a neutralizing antibody Z23-Fab Deposited 2016-10-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；3 uL Zika virus-Z23 Fab complex sample was transferred onto a glow-discharged ultra-thin carbon-coated copper grid (Purchased from Zhongjingkeyi Company, China) followed by 60s waiting and blotted for 2s with filter paper before plugging into liquid ethane using the FEI Vitrobot Mark IV
Resolution 9.40 Å
5GZR Zika virus E protein complexed with a neutralizing antibody Z23-Fab Deposited 2016-10-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 50 PDB declaration: 50-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；3 uL Zika virus-Z23 Fab complex sample was transferred onto a glow-discharged ultra-thin carbon-coated copper grid (Purchased from Zhongjingkeyi Company, China) followed by 60s waiting and blotted for 2s with filter paper before plugging into liquid ethane using the FEI Vitrobot Mark IV
Resolution 9.40 Å
5GZR Zika virus E protein complexed with a neutralizing antibody Z23-Fab Deposited 2016-10-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 60 PDB declaration: 60-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；3 uL Zika virus-Z23 Fab complex sample was transferred onto a glow-discharged ultra-thin carbon-coated copper grid (Purchased from Zhongjingkeyi Company, China) followed by 60s waiting and blotted for 2s with filter paper before plugging into liquid ethane using the FEI Vitrobot Mark IV
Resolution 9.40 Å
5GZR Zika virus E protein complexed with a neutralizing antibody Z23-Fab Deposited 2016-10-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；3 uL Zika virus-Z23 Fab complex sample was transferred onto a glow-discharged ultra-thin carbon-coated copper grid (Purchased from Zhongjingkeyi Company, China) followed by 60s waiting and blotted for 2s with filter paper before plugging into liquid ethane using the FEI Vitrobot Mark IV
Resolution 9.40 Å
5GZR Zika virus E protein complexed with a neutralizing antibody Z23-Fab Deposited 2016-10-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 6 Protein heterocomplex Heteromer；Protein × 600 PDB declaration: 600-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；3 uL Zika virus-Z23 Fab complex sample was transferred onto a glow-discharged ultra-thin carbon-coated copper grid (Purchased from Zhongjingkeyi Company, China) followed by 60s waiting and blotted for 2s with filter paper before plugging into liquid ethane using the FEI Vitrobot Mark IV
Resolution 9.40 Å
5H30 Cryo-EM structure of zika virus complexed with Fab C10 at pH 6.5 Deposited 2016-10-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 720 PDB declaration: 720-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.40 Å
5H30 Cryo-EM structure of zika virus complexed with Fab C10 at pH 6.5 Deposited 2016-10-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.40 Å
5H30 Cryo-EM structure of zika virus complexed with Fab C10 at pH 6.5 Deposited 2016-10-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 60 PDB declaration: 60-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.40 Å
5H30 Cryo-EM structure of zika virus complexed with Fab C10 at pH 6.5 Deposited 2016-10-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 72 PDB declaration: 72-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.40 Å
5H30 Cryo-EM structure of zika virus complexed with Fab C10 at pH 6.5 Deposited 2016-10-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.40 Å
5H30 Cryo-EM structure of zika virus complexed with Fab C10 at pH 6.5 Deposited 2016-10-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 6 Protein heterocomplex Heteromer；Protein × 720 PDB declaration: 720-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.40 Å
5H32 Cryo-EM structure of zika virus complexed with Fab C10 at pH 5.0 Deposited 2016-10-20 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 540 PDB declaration: 540-meric
Chain A 291–693（403 aa）
Chain B 291–693（403 aa）
Chain C 291–693（403 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å
5H32 Cryo-EM structure of zika virus complexed with Fab C10 at pH 5.0 Deposited 2016-10-20 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 291–693（403 aa）
Chain B 291–693（403 aa）
Chain C 291–693（403 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å
5H32 Cryo-EM structure of zika virus complexed with Fab C10 at pH 5.0 Deposited 2016-10-20 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric
Chain A 291–693（403 aa）
Chain B 291–693（403 aa）
Chain C 291–693（403 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å
5H32 Cryo-EM structure of zika virus complexed with Fab C10 at pH 5.0 Deposited 2016-10-20 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 54 PDB declaration: 54-meric
Chain A 291–693（403 aa）
Chain B 291–693（403 aa）
Chain C 291–693（403 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å
5H32 Cryo-EM structure of zika virus complexed with Fab C10 at pH 5.0 Deposited 2016-10-20 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 291–693（403 aa）
Chain B 291–693（403 aa）
Chain C 291–693（403 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å
5H32 Cryo-EM structure of zika virus complexed with Fab C10 at pH 5.0 Deposited 2016-10-20 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 6 Protein heterocomplex Heteromer；Protein × 540 PDB declaration: 540-meric
Chain A 291–693（403 aa）
Chain B 291–693（403 aa）
Chain C 291–693（403 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å
5H37 Cryo-EM structure of zika virus complexed with Fab C10 at pH 8.0 Deposited 2016-10-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 720 PDB declaration: 720-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 60 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
5H37 Cryo-EM structure of zika virus complexed with Fab C10 at pH 8.0 Deposited 2016-10-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
5H37 Cryo-EM structure of zika virus complexed with Fab C10 at pH 8.0 Deposited 2016-10-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 60 PDB declaration: 60-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
5H37 Cryo-EM structure of zika virus complexed with Fab C10 at pH 8.0 Deposited 2016-10-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 72 PDB declaration: 72-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
5H37 Cryo-EM structure of zika virus complexed with Fab C10 at pH 8.0 Deposited 2016-10-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
5H37 Cryo-EM structure of zika virus complexed with Fab C10 at pH 8.0 Deposited 2016-10-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 6 Protein heterocomplex Heteromer；Protein × 720 PDB declaration: 720-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 216–290（75 aa）
Chain E 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 60 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
5IY3 Zika Virus Non-structural Protein NS1 Deposited 2016-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 966–1146（181 aa） Fragment：UNP residues 966-1146
Chain B 966–1146（181 aa） Fragment：UNP residues 966-1146
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.09 M NPS mix[NaNO3, Na2HPO4, (NH4)2SO4], 0.1 M buffer mix (Imidazole, Sodium Cacodylate, MES; Bis-Tris) pH 6.5, 37.5% MPD_P1K_P3350 mix(MPD, PEG 1000, PEG 3350)
Resolution 2.20 Å R-free 0.246
5JMT Crystal structure of Zika virus NS3 helicase Deposited 2016-04-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1674–2119（446 aa） Fragment：UNP residues 1674-2119
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 5.2；291 K；0.1 M Sodium citrate tribasic dihydrate (pH 5.5), 22%(w/v) polyethylene glycol 1000
Resolution 1.80 Å R-free 0.200
5KVD Zika specific antibody, ZV-2, bound to ZIKA envelope DIII Deposited 2016-07-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain E 589–697（109 aa） Fragment：UNP residues 589-697
Not recorded NA SODIUM ION × 2 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M MES pH6.5, 0.6 M NaCl and 20.6% PEG 4000
Resolution 1.65 Å R-free 0.221
5KVF Zika specific antibody, ZV-64, bound to ZIKA envelope DIII Deposited 2016-07-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain E 589–697（109 aa） Fragment：UNP residues 589-697
Not recorded GOL GLYCEROL × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M sodium acetate and 22% PEG4000
Resolution 1.40 Å R-free 0.186
5KVG Zika specific antibody, ZV-67, bound to ZIKA envelope DIII Deposited 2016-07-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain E 589–697（109 aa） Fragment：UNP residues 589-697
Not recorded CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M Ammonium formate, 20% PEG 3350
Resolution 1.40 Å R-free 0.179
6CO8 Structure of Zika virus at a resolution of 3.1 Angstrom Deposited 2018-03-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Homooligomer；Protein × 360 PDB declaration: 360-meric
Chain A 291–794（504 aa） Fragment：UNP residues 291-794
Chain B 216–290（75 aa） Fragment：UNP residues 216-290
Chain C 291–794（504 aa） Fragment：UNP residues 291-794
Chain D 216–290（75 aa） Fragment：UNP residues 216-290
Chain E 291–794（504 aa） Fragment：UNP residues 291-794
Chain F 216–290（75 aa） Fragment：UNP residues 216-290
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；12 mM Tris-HCl, pH 8, 120 mM NaCl, 1 mM EDTA
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
6CO8 Structure of Zika virus at a resolution of 3.1 Angstrom Deposited 2018-03-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 291–794（504 aa） Fragment：UNP residues 291-794
Chain B 216–290（75 aa） Fragment：UNP residues 216-290
Chain C 291–794（504 aa） Fragment：UNP residues 291-794
Chain D 216–290（75 aa） Fragment：UNP residues 216-290
Chain E 291–794（504 aa） Fragment：UNP residues 291-794
Chain F 216–290（75 aa） Fragment：UNP residues 216-290
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；12 mM Tris-HCl, pH 8, 120 mM NaCl, 1 mM EDTA
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
6CO8 Structure of Zika virus at a resolution of 3.1 Angstrom Deposited 2018-03-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Other combination Homooligomer；Protein × 30 PDB declaration: 30-meric
Chain A 291–794（504 aa） Fragment：UNP residues 291-794
Chain B 216–290（75 aa） Fragment：UNP residues 216-290
Chain C 291–794（504 aa） Fragment：UNP residues 291-794
Chain D 216–290（75 aa） Fragment：UNP residues 216-290
Chain E 291–794（504 aa） Fragment：UNP residues 291-794
Chain F 216–290（75 aa） Fragment：UNP residues 216-290
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；12 mM Tris-HCl, pH 8, 120 mM NaCl, 1 mM EDTA
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
6CO8 Structure of Zika virus at a resolution of 3.1 Angstrom Deposited 2018-03-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Other combination Homooligomer；Protein × 36 PDB declaration: 36-meric
Chain A 291–794（504 aa） Fragment：UNP residues 291-794
Chain B 216–290（75 aa） Fragment：UNP residues 216-290
Chain C 291–794（504 aa） Fragment：UNP residues 291-794
Chain D 216–290（75 aa） Fragment：UNP residues 216-290
Chain E 291–794（504 aa） Fragment：UNP residues 291-794
Chain F 216–290（75 aa） Fragment：UNP residues 216-290
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；12 mM Tris-HCl, pH 8, 120 mM NaCl, 1 mM EDTA
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
6CO8 Structure of Zika virus at a resolution of 3.1 Angstrom Deposited 2018-03-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 291–794（504 aa） Fragment：UNP residues 291-794
Chain B 216–290（75 aa） Fragment：UNP residues 216-290
Chain C 291–794（504 aa） Fragment：UNP residues 291-794
Chain D 216–290（75 aa） Fragment：UNP residues 216-290
Chain E 291–794（504 aa） Fragment：UNP residues 291-794
Chain F 216–290（75 aa） Fragment：UNP residues 216-290
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；12 mM Tris-HCl, pH 8, 120 mM NaCl, 1 mM EDTA
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
6JFH The asymmetric-reconstructed cryo-EM structure of Zika virus-FabZK2B10 complex Deposited 2019-02-08 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain B 216–290（75 aa）
Chain D 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 20.00 Å
6JFI The symmetric-reconstructed cryo-EM structure of Zika virus-FabZK2B10 complex Deposited 2019-02-08 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 600 PDB declaration: 600-meric
Chain B 216–290（75 aa）
Chain D 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 11.00 Å
6JFI The symmetric-reconstructed cryo-EM structure of Zika virus-FabZK2B10 complex Deposited 2019-02-08 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain B 216–290（75 aa）
Chain D 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 11.00 Å
6JFI The symmetric-reconstructed cryo-EM structure of Zika virus-FabZK2B10 complex Deposited 2019-02-08 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 50 PDB declaration: 50-meric
Chain B 216–290（75 aa）
Chain D 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 11.00 Å
6JFI The symmetric-reconstructed cryo-EM structure of Zika virus-FabZK2B10 complex Deposited 2019-02-08 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 60 PDB declaration: 60-meric
Chain B 216–290（75 aa）
Chain D 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 11.00 Å
6JFI The symmetric-reconstructed cryo-EM structure of Zika virus-FabZK2B10 complex Deposited 2019-02-08 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain B 216–290（75 aa）
Chain D 216–290（75 aa）
Chain F 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 11.00 Å
6LD1 Zika NS5 polymerase domain Deposited 2019-11-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2790–3411（622 aa）
Not recorded EDO 1,2-ETHANEDIOL × 3 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；293 K；10% PEG 6000, 0.2M HEPES pH 7.5
Resolution 1.40 Å R-free 0.218
6LD2 Zika NS5 polymerase domain Deposited 2019-11-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2790–3411（622 aa）
Not recorded ZN ZINC ION × 2 KY3 (1S,2S,4S,5R)-2,4-dimethoxy-5-thiophen-2-yl-cyclohexane-1-carboxylic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；10% PEG 6000, 0.2M HEPES pH7.5
Resolution 1.40 Å R-free 0.227
6LD3 Zika NS5 polymerase domain Deposited 2019-11-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2790–3411（622 aa）
Not recorded ZN ZINC ION × 2 G8O 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid × 1 FB2 benzenesulfonamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；10% PEG 6000, 0.2M HEPES pH 7.5
Resolution 2.30 Å R-free 0.249
6LD4 Zika NS5 polymerase domain Deposited 2019-11-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2790–3411（622 aa）
Not recorded ZN ZINC ION × 2 G8O 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid × 1 G8F 3-methoxybenzenesulfonamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；10% PEG 6000, 0.2M HEPES pH7.5
Resolution 1.50 Å R-free 0.224
6LD5 Zika NS5 polymerase domain Deposited 2019-11-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2790–3411（622 aa）
Not recorded ZN ZINC ION × 2 G8O 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid × 1 G8L quinoline-8-sulfonamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；10% PEG 6000, 0.2M HEPES pH 7.4
Resolution 1.94 Å R-free 0.226
6LNT Cryo-EM structure of immature Zika virus in complex with human antibody DV62.5 Fab Deposited 2020-01-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 720 PDB declaration: 720-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 128–290（163 aa）
Chain E 128–290（163 aa）
Chain F 128–290（163 aa）
Chain M 6–122（117 aa）
Chain N 6–122（117 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；10 mM Tris-HCl, 120 mM NaCl, 1 mM EDTA, pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.00 Å
6LNT Cryo-EM structure of immature Zika virus in complex with human antibody DV62.5 Fab Deposited 2020-01-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 128–290（163 aa）
Chain E 128–290（163 aa）
Chain F 128–290（163 aa）
Chain M 6–122（117 aa）
Chain N 6–122（117 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；10 mM Tris-HCl, 120 mM NaCl, 1 mM EDTA, pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.00 Å
6LNT Cryo-EM structure of immature Zika virus in complex with human antibody DV62.5 Fab Deposited 2020-01-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 60 PDB declaration: 60-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 128–290（163 aa）
Chain E 128–290（163 aa）
Chain F 128–290（163 aa）
Chain M 6–122（117 aa）
Chain N 6–122（117 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；10 mM Tris-HCl, 120 mM NaCl, 1 mM EDTA, pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.00 Å
6LNT Cryo-EM structure of immature Zika virus in complex with human antibody DV62.5 Fab Deposited 2020-01-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 72 PDB declaration: 72-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 128–290（163 aa）
Chain E 128–290（163 aa）
Chain F 128–290（163 aa）
Chain M 6–122（117 aa）
Chain N 6–122（117 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；10 mM Tris-HCl, 120 mM NaCl, 1 mM EDTA, pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.00 Å
6LNT Cryo-EM structure of immature Zika virus in complex with human antibody DV62.5 Fab Deposited 2020-01-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 128–290（163 aa）
Chain E 128–290（163 aa）
Chain F 128–290（163 aa）
Chain M 6–122（117 aa）
Chain N 6–122（117 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；10 mM Tris-HCl, 120 mM NaCl, 1 mM EDTA, pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.00 Å
6LNU Cryo-EM structure of immature Zika virus Deposited 2020-01-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 360 PDB declaration: 360-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 128–290（163 aa）
Chain E 128–290（163 aa）
Chain F 128–290（163 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；10 mM Tris-HCl, 120 mM NaCl, 1 mM EDTA, pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 9.00 Å
6LNU Cryo-EM structure of immature Zika virus Deposited 2020-01-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 128–290（163 aa）
Chain E 128–290（163 aa）
Chain F 128–290（163 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；10 mM Tris-HCl, 120 mM NaCl, 1 mM EDTA, pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 9.00 Å
6LNU Cryo-EM structure of immature Zika virus Deposited 2020-01-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein homooligomer Homooligomer；Protein × 30 PDB declaration: 30-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 128–290（163 aa）
Chain E 128–290（163 aa）
Chain F 128–290（163 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；10 mM Tris-HCl, 120 mM NaCl, 1 mM EDTA, pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 9.00 Å
6LNU Cryo-EM structure of immature Zika virus Deposited 2020-01-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein homooligomer Homooligomer；Protein × 36 PDB declaration: 36-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 128–290（163 aa）
Chain E 128–290（163 aa）
Chain F 128–290（163 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；10 mM Tris-HCl, 120 mM NaCl, 1 mM EDTA, pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 9.00 Å
6LNU Cryo-EM structure of immature Zika virus Deposited 2020-01-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Chain D 128–290（163 aa）
Chain E 128–290（163 aa）
Chain F 128–290（163 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；10 mM Tris-HCl, 120 mM NaCl, 1 mM EDTA, pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 9.00 Å
6MID Cryo-EM structure of the ZIKV virion in complex with Fab fragments of the potently neutralizing human monoclonal antibody ZIKV-195 Deposited 2018-09-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 480 PDB declaration: 480-meric
Chain A 291–794（504 aa） Fragment：UNP residues 291-794
Chain B 216–290（75 aa） Fragment：UNP residues 216-290
Chain C 291–794（504 aa） Fragment：UNP residues 291-794
Chain D 216–290（75 aa） Fragment：UNP residues 216-290
Chain E 291–794（504 aa） Fragment：UNP residues 291-794
Chain F 216–290（75 aa） Fragment：UNP residues 216-290
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；NTE buffer at pH 8.0
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
6MID Cryo-EM structure of the ZIKV virion in complex with Fab fragments of the potently neutralizing human monoclonal antibody ZIKV-195 Deposited 2018-09-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Other combination Heteromer；Protein × 8 PDB declaration: octameric
Chain A 291–794（504 aa） Fragment：UNP residues 291-794
Chain B 216–290（75 aa） Fragment：UNP residues 216-290
Chain C 291–794（504 aa） Fragment：UNP residues 291-794
Chain D 216–290（75 aa） Fragment：UNP residues 216-290
Chain E 291–794（504 aa） Fragment：UNP residues 291-794
Chain F 216–290（75 aa） Fragment：UNP residues 216-290
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；NTE buffer at pH 8.0
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
6MID Cryo-EM structure of the ZIKV virion in complex with Fab fragments of the potently neutralizing human monoclonal antibody ZIKV-195 Deposited 2018-09-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Other combination Heteromer；Protein × 40 PDB declaration: 40-meric
Chain A 291–794（504 aa） Fragment：UNP residues 291-794
Chain B 216–290（75 aa） Fragment：UNP residues 216-290
Chain C 291–794（504 aa） Fragment：UNP residues 291-794
Chain D 216–290（75 aa） Fragment：UNP residues 216-290
Chain E 291–794（504 aa） Fragment：UNP residues 291-794
Chain F 216–290（75 aa） Fragment：UNP residues 216-290
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；NTE buffer at pH 8.0
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
6MID Cryo-EM structure of the ZIKV virion in complex with Fab fragments of the potently neutralizing human monoclonal antibody ZIKV-195 Deposited 2018-09-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Other combination Heteromer；Protein × 48 PDB declaration: 48-meric
Chain A 291–794（504 aa） Fragment：UNP residues 291-794
Chain B 216–290（75 aa） Fragment：UNP residues 216-290
Chain C 291–794（504 aa） Fragment：UNP residues 291-794
Chain D 216–290（75 aa） Fragment：UNP residues 216-290
Chain E 291–794（504 aa） Fragment：UNP residues 291-794
Chain F 216–290（75 aa） Fragment：UNP residues 216-290
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；NTE buffer at pH 8.0
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
6MID Cryo-EM structure of the ZIKV virion in complex with Fab fragments of the potently neutralizing human monoclonal antibody ZIKV-195 Deposited 2018-09-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Other combination Heteromer；Protein × 8 PDB declaration: octameric
Chain A 291–794（504 aa） Fragment：UNP residues 291-794
Chain B 216–290（75 aa） Fragment：UNP residues 216-290
Chain C 291–794（504 aa） Fragment：UNP residues 291-794
Chain D 216–290（75 aa） Fragment：UNP residues 216-290
Chain E 291–794（504 aa） Fragment：UNP residues 291-794
Chain F 216–290（75 aa） Fragment：UNP residues 216-290
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；NTE buffer at pH 8.0
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
6NIP Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ1 in complex with ZIKV E glycoprotein Deposited 2018-12-31 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 291–695（405 aa）
Chain Z 291–695（405 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6.5；291 K；0.06 M MgCl2, 0.1M Imidazole MES monohydrate (pH 6.5), 20% Ethylene glycol and 10% PEG 8,000
Resolution 4.16 Å R-free 0.237
6NIU Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ4 in complex with ZIKV E glycoprotein Deposited 2018-12-31 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 291–695（405 aa）
Chain Z 291–695（405 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；291 K；1.26 M ammonium sulfate, 0.1 M CHES/NaOH (pH 9.5) and 0.2 M sodium chloride
Resolution 4.30 Å R-free 0.359
6NIU Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ4 in complex with ZIKV E glycoprotein Deposited 2018-12-31 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 291–695（405 aa）
Chain B 291–695（405 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；291 K；1.26 M ammonium sulfate, 0.1 M CHES/NaOH (pH 9.5) and 0.2 M sodium chloride
Resolution 4.30 Å R-free 0.359
7BSD Complex structure of 1G5.3 Fab bound to ZIKV NS1c Deposited 2020-03-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain G 966–1146（181 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；14% v/vPoly(acrylic acid-co-maleic acid) solution
Resolution 2.53 Å R-free 0.239
7BSD Complex structure of 1G5.3 Fab bound to ZIKV NS1c Deposited 2020-03-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain I 966–1146（181 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；14% v/vPoly(acrylic acid-co-maleic acid) solution
Resolution 2.53 Å R-free 0.239
7BU8 Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 6.5 Deposited 2020-04-05 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 720 PDB declaration: 720-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 180 ELECTRON MICROSCOPY
cryo-EM buffer pH 6.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
7BU8 Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 6.5 Deposited 2020-04-05 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 6.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
7BU8 Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 6.5 Deposited 2020-04-05 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 60 PDB declaration: 60-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 6.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
7BU8 Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 6.5 Deposited 2020-04-05 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 72 PDB declaration: 72-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 ELECTRON MICROSCOPY
cryo-EM buffer pH 6.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
7BU8 Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 6.5 Deposited 2020-04-05 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 6.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
7BUA Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 8.0 Deposited 2020-04-06 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 720 PDB declaration: 720-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 180 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.80 Å
7BUA Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 8.0 Deposited 2020-04-06 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.80 Å
7BUA Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 8.0 Deposited 2020-04-06 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 60 PDB declaration: 60-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.80 Å
7BUA Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 8.0 Deposited 2020-04-06 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 72 PDB declaration: 72-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.80 Å
7BUA Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 8.0 Deposited 2020-04-06 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.80 Å
7CBP CryoEM structure of Zika virus with Fab at 4.1 Angstrom Deposited 2020-06-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 600 PDB declaration: 600-meric
Chain K 291–791（501 aa）
Chain N 291–791（501 aa）
Chain Q 291–791（501 aa）
Chain T 216–290（75 aa）
Chain U 216–290（75 aa）
Chain V 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.10 Å
7CBP CryoEM structure of Zika virus with Fab at 4.1 Angstrom Deposited 2020-06-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Other combination Heteromer；Protein × 10 PDB declaration: decameric
Chain K 291–791（501 aa）
Chain N 291–791（501 aa）
Chain Q 291–791（501 aa）
Chain T 216–290（75 aa）
Chain U 216–290（75 aa）
Chain V 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.10 Å
7CBP CryoEM structure of Zika virus with Fab at 4.1 Angstrom Deposited 2020-06-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Other combination Heteromer；Protein × 50 PDB declaration: 50-meric
Chain K 291–791（501 aa）
Chain N 291–791（501 aa）
Chain Q 291–791（501 aa）
Chain T 216–290（75 aa）
Chain U 216–290（75 aa）
Chain V 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.10 Å
7CBP CryoEM structure of Zika virus with Fab at 4.1 Angstrom Deposited 2020-06-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Other combination Heteromer；Protein × 60 PDB declaration: 60-meric
Chain K 291–791（501 aa）
Chain N 291–791（501 aa）
Chain Q 291–791（501 aa）
Chain T 216–290（75 aa）
Chain U 216–290（75 aa）
Chain V 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.10 Å
7CBP CryoEM structure of Zika virus with Fab at 4.1 Angstrom Deposited 2020-06-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Other combination Heteromer；Protein × 10 PDB declaration: decameric
Chain K 291–791（501 aa）
Chain N 291–791（501 aa）
Chain Q 291–791（501 aa）
Chain T 216–290（75 aa）
Chain U 216–290（75 aa）
Chain V 216–290（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.10 Å
7YAR ZIKV_Fab_G9E Deposited 2022-06-28 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 720 PDB declaration: 720-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.90 Å
7YAR ZIKV_Fab_G9E Deposited 2022-06-28 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.90 Å
7YAR ZIKV_Fab_G9E Deposited 2022-06-28 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 60 PDB declaration: 60-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.90 Å
7YAR ZIKV_Fab_G9E Deposited 2022-06-28 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 72 PDB declaration: 72-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.90 Å
7YAR ZIKV_Fab_G9E Deposited 2022-06-28 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.90 Å
8EE5 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ119-D in complex with ZIKV E glycoprotein Deposited 2022-09-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric
Chain Z 291–695（405 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；0.06M Nitrate Phosphate Sulfate , 0.1M Sodium HEPES and MOPS (acid) pH 7.5, 20% Ethylene glycol, 10 % PEG 8000 + 2% w/v Benzamidine hydrochloride
Resolution 3.58 Å R-free 0.296
8EE8 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ100-C in complex with ZIKV E glycoprotein Deposited 2022-09-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 291–695（405 aa）
Chain B 291–695（405 aa）
Chain E 291–695（405 aa）
Chain Z 291–695（405 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；12% PEG 8000, 0.2 M (NH4)2SO4, 0.1M Tris (pH 8.5)
Resolution 2.80 Å R-free 0.295
8EED Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ107-B in complex with ZIKV E glycoprotein Deposited 2022-09-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 291–695（405 aa）
Chain B 291–695（405 aa）
Chain C 291–695（405 aa）
Chain D 291–695（405 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；15% PEG 6000, 5% MPD, 0.1 M MES (pH 6.5)
Resolution 3.49 Å R-free 0.331
8EEE Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ104-d in complex with ZIKV E glycoprotein Deposited 2022-09-07 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 291–695（405 aa）
Chain Z 291–695（405 aa）
Not recorded SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；12% PEG 8000, 0.2 M (NH4)2SO4, 0.1M Tris-HCl (pH 8.5)
Resolution 2.82 Å R-free 0.275
9JS6 cryoEM of antibody complexed with immature Zika virus Deposited 2024-09-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 480 PDB declaration: 480-meric
Chain A 292–794（503 aa）
Chain B 292–794（503 aa）
Chain C 292–794（503 aa）
Chain D 128–290（163 aa）
Chain E 128–290（163 aa）
Chain F 128–290（163 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
9JS6 cryoEM of antibody complexed with immature Zika virus Deposited 2024-09-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 292–794（503 aa）
Chain B 292–794（503 aa）
Chain C 292–794（503 aa）
Chain D 128–290（163 aa）
Chain E 128–290（163 aa）
Chain F 128–290（163 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
9JS6 cryoEM of antibody complexed with immature Zika virus Deposited 2024-09-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 40 PDB declaration: 40-meric
Chain A 292–794（503 aa）
Chain B 292–794（503 aa）
Chain C 292–794（503 aa）
Chain D 128–290（163 aa）
Chain E 128–290（163 aa）
Chain F 128–290（163 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
9JS6 cryoEM of antibody complexed with immature Zika virus Deposited 2024-09-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 48 PDB declaration: 48-meric
Chain A 292–794（503 aa）
Chain B 292–794（503 aa）
Chain C 292–794（503 aa）
Chain D 128–290（163 aa）
Chain E 128–290（163 aa）
Chain F 128–290（163 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
9JS6 cryoEM of antibody complexed with immature Zika virus Deposited 2024-09-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 292–794（503 aa）
Chain B 292–794（503 aa）
Chain C 292–794（503 aa）
Chain D 128–290（163 aa）
Chain E 128–290（163 aa）
Chain F 128–290（163 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
9JS7 cryoEM of antibody complexed with mature Zika virus Deposited 2024-09-30 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 420 PDB declaration: 420-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.84 Å
9JS7 cryoEM of antibody complexed with mature Zika virus Deposited 2024-09-30 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.84 Å
9JS7 cryoEM of antibody complexed with mature Zika virus Deposited 2024-09-30 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.84 Å
9JS7 cryoEM of antibody complexed with mature Zika virus Deposited 2024-09-30 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.84 Å
9JS7 cryoEM of antibody complexed with mature Zika virus Deposited 2024-09-30 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain A 291–794（504 aa）
Chain B 291–794（504 aa）
Chain C 291–794（504 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.84 Å
9OD2 Cryo-EM structure of modified Zika virus E protein dimer complexed with a neutralizing antibody SMZAb2 Fab Deposited 2025-04-25 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 290–695（406 aa）
Chain B 290–695（406 aa）
Mutation：G5C, G102C Mutation：G5C, G102C No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.09 Å
9XYB Crystal structure of a ZIKV E glycoprotein DI-DIII vaccine candidate in complex with human neutralizing antibody MZ4 Deposited 2025-08-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain E 291–342（52 aa）
Chain E 425–486（62 aa）
Chain E 576–695（120 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；40% (v/v) pentaerythritol propoxylate (5/4 PO/OH), 15% (v/v) ethanol
Resolution 2.85 Å R-free 0.316

35 other PDB entries and 101 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name A0A024B7W1_ZIKV
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–504； UniProt 291–794 Author chain B； PDBConstruct 1–504； UniProt 291–794 Author chain C； PDBConstruct 1–504； UniProt 291–794

structural protein M

OrganismNot specified

UniProt A0A0U4DG08

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 360 PDB declaration: 360-meric（360） Consistent with protein copy count Chain D； UniProt 216–290 Chain E； UniProt 216–290 Chain F； UniProt 216–290 Not recorded structural protein E × 180 （A0A024B7W1） NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 180 ELECTRON MICROSCOPY cryo-EM buffer：pH 8 cryo-EM vitrification conditions：Cryogen ETHANE；blot for 1s Resolution 3.70 Å
2 Protein heterocomplex Heteromer Protein × 6 PDB declaration: hexameric（6） Consistent with protein copy count Chain D； UniProt 216–290 Chain E； UniProt 216–290 Chain F； UniProt 216–290 Not recorded structural protein E × 3 （A0A024B7W1） NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ELECTRON MICROSCOPY cryo-EM buffer：pH 8 cryo-EM vitrification conditions：Cryogen ETHANE；blot for 1s Resolution 3.70 Å
3 Protein heterocomplex Heteromer Protein × 30 PDB declaration: 30-meric（30） Consistent with protein copy count Chain D； UniProt 216–290 Chain E； UniProt 216–290 Chain F； UniProt 216–290 Not recorded structural protein E × 15 （A0A024B7W1） NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 ELECTRON MICROSCOPY cryo-EM buffer：pH 8 cryo-EM vitrification conditions：Cryogen ETHANE；blot for 1s Resolution 3.70 Å
4 Protein heterocomplex Heteromer Protein × 36 PDB declaration: 36-meric（36） Consistent with protein copy count Chain D； UniProt 216–290 Chain E； UniProt 216–290 Chain F； UniProt 216–290 Not recorded structural protein E × 18 （A0A024B7W1） NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 ELECTRON MICROSCOPY cryo-EM buffer：pH 8 cryo-EM vitrification conditions：Cryogen ETHANE；blot for 1s Resolution 3.70 Å
5 Protein heterocomplex Heteromer Protein × 6 PDB declaration: hexameric（6） Consistent with protein copy count Chain D； UniProt 216–290 Chain E； UniProt 216–290 Chain F； UniProt 216–290 Not recorded structural protein E × 3 （A0A024B7W1） NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ELECTRON MICROSCOPY cryo-EM buffer：pH 8 cryo-EM vitrification conditions：Cryogen ETHANE；blot for 1s Resolution 3.70 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

No other PDB entry for the same UniProt protein was found.

View Construct and Data Evidence
UniProt name A0A0U4DG08_ZIKV
Isoform —
PDB entities 2
Chains and sequence ranges Author chain D； PDBConstruct 1–75； UniProt 216–290 Author chain E； PDBConstruct 1–75； UniProt 216–290 Author chain F； PDBConstruct 1–75； UniProt 216–290

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 5iz7

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 5iz7
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2. Structure Basics 2. Structure Basics

Entry ID entry_id5iz7
Deposition date deposition_date2016-03-25
Structure title titleCryo-EM structure of thermally stable Zika virus strain H/PF/2013
Keywords keywordsviral protein, flavivirus, glycoprotein, zika virus, VIRUS; VIRUS
Experimental Method methodELECTRON MICROSCOPY
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier46.44 Å
Radius of gyration Rg (electron density) rg_electron46.87 Å
Forward intensity I(0) i0535112000.00
Molecular weight molecular_weight189150.0 kDa
Excluded volume excluded_volume236520 ų
Envelope volume envelope_volume325170 ų
Hydration-shell volume shell_volume62744 ų
Envelope diameter envelope_diameter189.5 Å
Shell Rg shell_rg46.95 Å
Envelope Rg envelope_rg45.77 Å
Shape Rg shape_rg46.83 Å
Total Rg total_rg47.04 Å
Total atoms total_atoms13268
Residues n_residues1737
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax174.5 Å
Rg (real space) rg_real47.00 Å
Rg uncertainty (real space) rg_real_error2.83 Å
I(0) (real space) i0_real5.3510e+08
I(0) uncertainty (real space) i0_real_error1.2000e+07
Rg (reciprocal space) rg_reciprocal46.44 Å
I(0) (reciprocal space) i0_reciprocal534700000.0000
Solution quality estimate total_estimate0.8089
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks2
Primary peak position r_peak_primary51.3 Å
Skewness Skewness skewness0.669
Kurtosis Kurtosis kurtosis0.199
Angular range angular_range— – 0.1700 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha33670000.0000
Real-space data points n_real_points35
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.589; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.905; Smooth: 0.839
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (3)

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7. Fold Classification (SCOP + CATH) 18 domains

CATH v4.4 (18 domains)

Domain ID domain_id5iz7A01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology98 — Tick-borne Encephalitis virus Glycoprotein; domain 1
Homologous superfamily homologous superfamily10 — Tick-borne Encephalitis virus Glycoprotein, domain 1
Domain ID domain_id5iz7A02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology67 — Viral Envelope Glycoprotein; domain 2
Homologous superfamily homologous superfamily10 — Viral Envelope Glycoprotein, domain 2
Domain ID domain_id5iz7A03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology387 — Viral Envelope Glycoprotein; domain 3
Homologous superfamily homologous superfamily10 — Viral Envelope Glycoprotein, domain 3
Domain ID domain_id5iz7A04
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily350 —
Domain ID domain_id5iz7A05
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1280 — Monooxygenase
Homologous superfamily homologous superfamily260 —
Domain ID domain_id5iz7B01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology98 — Tick-borne Encephalitis virus Glycoprotein; domain 1
Homologous superfamily homologous superfamily10 — Tick-borne Encephalitis virus Glycoprotein, domain 1
Domain ID domain_id5iz7B02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology67 — Viral Envelope Glycoprotein; domain 2
Homologous superfamily homologous superfamily10 — Viral Envelope Glycoprotein, domain 2
Domain ID domain_id5iz7B03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology387 — Viral Envelope Glycoprotein; domain 3
Homologous superfamily homologous superfamily10 — Viral Envelope Glycoprotein, domain 3
Domain ID domain_id5iz7B04
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily350 —
Domain ID domain_id5iz7B05
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1280 — Monooxygenase
Homologous superfamily homologous superfamily260 —
Domain ID domain_id5iz7C01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology98 — Tick-borne Encephalitis virus Glycoprotein; domain 1
Homologous superfamily homologous superfamily10 — Tick-borne Encephalitis virus Glycoprotein, domain 1
Domain ID domain_id5iz7C02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology67 — Viral Envelope Glycoprotein; domain 2
Homologous superfamily homologous superfamily10 — Viral Envelope Glycoprotein, domain 2
Domain ID domain_id5iz7C03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology387 — Viral Envelope Glycoprotein; domain 3
Homologous superfamily homologous superfamily10 — Viral Envelope Glycoprotein, domain 3
Domain ID domain_id5iz7C04
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily350 —
Domain ID domain_id5iz7C05
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1280 — Monooxygenase
Homologous superfamily homologous superfamily260 —
Domain ID domain_id5iz7D00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily970 — Flavivirus envelope glycoprotein M-like
Domain ID domain_id5iz7E00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily970 — Flavivirus envelope glycoprotein M-like
Domain ID domain_id5iz7F00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily970 — Flavivirus envelope glycoprotein M-like
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8. Citations (1)

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9. Files and Curves (10)