Type 1 fimbrin D-mannose specific adhesin
Escherichia coli (strain K12)
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain A； UniProt 22–179 | Not recorded | EJN (2~{R},3~{S},4~{S},5~{S},6~{R})-2-(hydroxymethyl)-6-[4-[2,3,4,5,6-pentakis(fluoranyl)phenyl]phenoxy]oxane-3,4,5-triol × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M BisTrisPropane, propionic acid, cacodylate (PCPT buffer) pH 8.0, 0.1 M (NH4)2SO4 and 25 % PEG1500 | Resolution 2.20 Å R-free 0.222 |
| 2 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain B； UniProt 22–179 | Not recorded | EJN (2~{R},3~{S},4~{S},5~{S},6~{R})-2-(hydroxymethyl)-6-[4-[2,3,4,5,6-pentakis(fluoranyl)phenyl]phenoxy]oxane-3,4,5-triol × 1 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M BisTrisPropane, propionic acid, cacodylate (PCPT buffer) pH 8.0, 0.1 M (NH4)2SO4 and 25 % PEG1500 | Resolution 2.20 Å R-free 0.222 |
| 3 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain C； UniProt 22–179 | Not recorded | EJN (2~{R},3~{S},4~{S},5~{S},6~{R})-2-(hydroxymethyl)-6-[4-[2,3,4,5,6-pentakis(fluoranyl)phenyl]phenoxy]oxane-3,4,5-triol × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M BisTrisPropane, propionic acid, cacodylate (PCPT buffer) pH 8.0, 0.1 M (NH4)2SO4 and 25 % PEG1500 | Resolution 2.20 Å R-free 0.222 |
| 4 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain D； UniProt 22–179 | Not recorded | EJN (2~{R},3~{S},4~{S},5~{S},6~{R})-2-(hydroxymethyl)-6-[4-[2,3,4,5,6-pentakis(fluoranyl)phenyl]phenoxy]oxane-3,4,5-triol × 1 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M BisTrisPropane, propionic acid, cacodylate (PCPT buffer) pH 8.0, 0.1 M (NH4)2SO4 and 25 % PEG1500 | Resolution 2.20 Å R-free 0.222 |
| 5 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain E； UniProt 22–179 | Not recorded | EJN (2~{R},3~{S},4~{S},5~{S},6~{R})-2-(hydroxymethyl)-6-[4-[2,3,4,5,6-pentakis(fluoranyl)phenyl]phenoxy]oxane-3,4,5-triol × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M BisTrisPropane, propionic acid, cacodylate (PCPT buffer) pH 8.0, 0.1 M (NH4)2SO4 and 25 % PEG1500 | Resolution 2.20 Å R-free 0.222 |
| 6 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain F； UniProt 22–179 | Not recorded | EJN (2~{R},3~{S},4~{S},5~{S},6~{R})-2-(hydroxymethyl)-6-[4-[2,3,4,5,6-pentakis(fluoranyl)phenyl]phenoxy]oxane-3,4,5-triol × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M BisTrisPropane, propionic acid, cacodylate (PCPT buffer) pH 8.0, 0.1 M (NH4)2SO4 and 25 % PEG1500 | Resolution 2.20 Å R-free 0.222 |
| 7 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain G； UniProt 22–179 | Not recorded | EJN (2~{R},3~{S},4~{S},5~{S},6~{R})-2-(hydroxymethyl)-6-[4-[2,3,4,5,6-pentakis(fluoranyl)phenyl]phenoxy]oxane-3,4,5-triol × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M BisTrisPropane, propionic acid, cacodylate (PCPT buffer) pH 8.0, 0.1 M (NH4)2SO4 and 25 % PEG1500 | Resolution 2.20 Å R-free 0.222 |
| 8 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain H； UniProt 22–179 | Not recorded | EJN (2~{R},3~{S},4~{S},5~{S},6~{R})-2-(hydroxymethyl)-6-[4-[2,3,4,5,6-pentakis(fluoranyl)phenyl]phenoxy]oxane-3,4,5-triol × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M BisTrisPropane, propionic acid, cacodylate (PCPT buffer) pH 8.0, 0.1 M (NH4)2SO4 and 25 % PEG1500 | Resolution 2.20 Å R-free 0.222 |
| 9 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain I； UniProt 22–179 | Not recorded | EJN (2~{R},3~{S},4~{S},5~{S},6~{R})-2-(hydroxymethyl)-6-[4-[2,3,4,5,6-pentakis(fluoranyl)phenyl]phenoxy]oxane-3,4,5-triol × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M BisTrisPropane, propionic acid, cacodylate (PCPT buffer) pH 8.0, 0.1 M (NH4)2SO4 and 25 % PEG1500 | Resolution 2.20 Å R-free 0.222 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 6G2S | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1KIU FimH adhesin Q133N mutant-FimC chaperone complex with methyl-alpha-D-mannose Deposited 2001-12-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
22–300（279 aa）
|
Mutation：Q133N | MMA methyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；297 K；ammonium sulphate, pH 8.2, VAPOR DIFFUSION, SITTING DROP, temperature 297K
|
Resolution 3.00 Å R-free 0.278 |
| 1KIU FimH adhesin Q133N mutant-FimC chaperone complex with methyl-alpha-D-mannose Deposited 2001-12-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 10 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain B
22–300（279 aa）
Chain H
22–300（279 aa）
Chain L
22–300（279 aa）
Chain P
22–300（279 aa）
|
Mutation：Q133N Mutation：Q133N Mutation：Q133N Mutation：Q133N | MMA methyl alpha-D-mannopyranoside × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；297 K；ammonium sulphate, pH 8.2, VAPOR DIFFUSION, SITTING DROP, temperature 297K
|
Resolution 3.00 Å R-free 0.278 |
| 1KIU FimH adhesin Q133N mutant-FimC chaperone complex with methyl-alpha-D-mannose Deposited 2001-12-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 11 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain F
22–300（279 aa）
Chain N
22–300（279 aa）
|
Mutation：Q133N Mutation：Q133N | MMA methyl alpha-D-mannopyranoside × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；297 K；ammonium sulphate, pH 8.2, VAPOR DIFFUSION, SITTING DROP, temperature 297K
|
Resolution 3.00 Å R-free 0.278 |
| 1KIU FimH adhesin Q133N mutant-FimC chaperone complex with methyl-alpha-D-mannose Deposited 2001-12-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
22–300（279 aa）
|
Mutation：Q133N | MMA methyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；297 K；ammonium sulphate, pH 8.2, VAPOR DIFFUSION, SITTING DROP, temperature 297K
|
Resolution 3.00 Å R-free 0.278 |
| 1KIU FimH adhesin Q133N mutant-FimC chaperone complex with methyl-alpha-D-mannose Deposited 2001-12-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain F
22–300（279 aa）
|
Mutation：Q133N | MMA methyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；297 K；ammonium sulphate, pH 8.2, VAPOR DIFFUSION, SITTING DROP, temperature 297K
|
Resolution 3.00 Å R-free 0.278 |
| 1KIU FimH adhesin Q133N mutant-FimC chaperone complex with methyl-alpha-D-mannose Deposited 2001-12-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
22–300（279 aa）
|
Mutation：Q133N | MMA methyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；297 K；ammonium sulphate, pH 8.2, VAPOR DIFFUSION, SITTING DROP, temperature 297K
|
Resolution 3.00 Å R-free 0.278 |
| 1KIU FimH adhesin Q133N mutant-FimC chaperone complex with methyl-alpha-D-mannose Deposited 2001-12-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain J
22–300（279 aa）
|
Mutation：Q133N | MMA methyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；297 K；ammonium sulphate, pH 8.2, VAPOR DIFFUSION, SITTING DROP, temperature 297K
|
Resolution 3.00 Å R-free 0.278 |
| 1KIU FimH adhesin Q133N mutant-FimC chaperone complex with methyl-alpha-D-mannose Deposited 2001-12-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain L
22–300（279 aa）
|
Mutation：Q133N | MMA methyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；297 K；ammonium sulphate, pH 8.2, VAPOR DIFFUSION, SITTING DROP, temperature 297K
|
Resolution 3.00 Å R-free 0.278 |
| 1KIU FimH adhesin Q133N mutant-FimC chaperone complex with methyl-alpha-D-mannose Deposited 2001-12-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 7 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain N
22–300（279 aa）
|
Mutation：Q133N | MMA methyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；297 K；ammonium sulphate, pH 8.2, VAPOR DIFFUSION, SITTING DROP, temperature 297K
|
Resolution 3.00 Å R-free 0.278 |
| 1KIU FimH adhesin Q133N mutant-FimC chaperone complex with methyl-alpha-D-mannose Deposited 2001-12-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 8 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain P
22–300（279 aa）
|
Mutation：Q133N | MMA methyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；297 K；ammonium sulphate, pH 8.2, VAPOR DIFFUSION, SITTING DROP, temperature 297K
|
Resolution 3.00 Å R-free 0.278 |
| 1KIU FimH adhesin Q133N mutant-FimC chaperone complex with methyl-alpha-D-mannose Deposited 2001-12-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 9 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain D
22–300（279 aa）
Chain J
22–300（279 aa）
|
Mutation：Q133N Mutation：Q133N | MMA methyl alpha-D-mannopyranoside × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；297 K；ammonium sulphate, pH 8.2, VAPOR DIFFUSION, SITTING DROP, temperature 297K
|
Resolution 3.00 Å R-free 0.278 |
| 1KLF FIMH ADHESIN-FIMC CHAPERONE COMPLEX WITH D-MANNOSE Deposited 2001-12-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
22–300（279 aa）
|
Not recorded | MAN alpha-D-mannopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；298 K；ammonium suplhate, pH 8.20, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.79 Å R-free 0.280 |
| 1KLF FIMH ADHESIN-FIMC CHAPERONE COMPLEX WITH D-MANNOSE Deposited 2001-12-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
22–300（279 aa）
|
Not recorded | MAN alpha-D-mannopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；298 K；ammonium suplhate, pH 8.20, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.79 Å R-free 0.280 |
| 1KLF FIMH ADHESIN-FIMC CHAPERONE COMPLEX WITH D-MANNOSE Deposited 2001-12-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain F
22–300（279 aa）
|
Not recorded | MAN alpha-D-mannopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；298 K；ammonium suplhate, pH 8.20, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.79 Å R-free 0.280 |
| 1KLF FIMH ADHESIN-FIMC CHAPERONE COMPLEX WITH D-MANNOSE Deposited 2001-12-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
22–300（279 aa）
|
Not recorded | MAN alpha-D-mannopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；298 K；ammonium suplhate, pH 8.20, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.79 Å R-free 0.280 |
| 1KLF FIMH ADHESIN-FIMC CHAPERONE COMPLEX WITH D-MANNOSE Deposited 2001-12-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain J
22–300（279 aa）
|
Not recorded | MAN alpha-D-mannopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；298 K；ammonium suplhate, pH 8.20, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.79 Å R-free 0.280 |
| 1KLF FIMH ADHESIN-FIMC CHAPERONE COMPLEX WITH D-MANNOSE Deposited 2001-12-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain L
22–300（279 aa）
|
Not recorded | MAN alpha-D-mannopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；298 K；ammonium suplhate, pH 8.20, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.79 Å R-free 0.280 |
| 1KLF FIMH ADHESIN-FIMC CHAPERONE COMPLEX WITH D-MANNOSE Deposited 2001-12-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 7 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain N
22–300（279 aa）
|
Not recorded | MAN alpha-D-mannopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；298 K；ammonium suplhate, pH 8.20, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.79 Å R-free 0.280 |
| 1KLF FIMH ADHESIN-FIMC CHAPERONE COMPLEX WITH D-MANNOSE Deposited 2001-12-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 8 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain P
22–300（279 aa）
|
Not recorded | MAN alpha-D-mannopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；298 K；ammonium suplhate, pH 8.20, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.79 Å R-free 0.280 |
| 1QUN X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI Deposited 1999-07-01 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
22–300（279 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；289 K；Ammonium Sulphate, Tris, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 2.80 Å R-free 0.268 |
| 1QUN X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI Deposited 1999-07-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 10 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain B
22–300（279 aa）
Chain H
22–300（279 aa）
Chain L
22–300（279 aa）
Chain P
22–300（279 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；289 K；Ammonium Sulphate, Tris, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 2.80 Å R-free 0.268 |
| 1QUN X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI Deposited 1999-07-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 11 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain D
22–300（279 aa）
Chain J
22–300（279 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；289 K；Ammonium Sulphate, Tris, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 2.80 Å R-free 0.268 |
| 1QUN X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI Deposited 1999-07-01 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
22–300（279 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；289 K；Ammonium Sulphate, Tris, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 2.80 Å R-free 0.268 |
| 1QUN X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI Deposited 1999-07-01 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain F
22–300（279 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；289 K；Ammonium Sulphate, Tris, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 2.80 Å R-free 0.268 |
| 1QUN X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI Deposited 1999-07-01 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
22–300（279 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；289 K；Ammonium Sulphate, Tris, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 2.80 Å R-free 0.268 |
| 1QUN X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI Deposited 1999-07-01 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain J
22–300（279 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；289 K；Ammonium Sulphate, Tris, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 2.80 Å R-free 0.268 |
| 1QUN X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI Deposited 1999-07-01 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain L
22–300（279 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；289 K；Ammonium Sulphate, Tris, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 2.80 Å R-free 0.268 |
| 1QUN X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI Deposited 1999-07-01 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 7 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain N
22–300（279 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；289 K；Ammonium Sulphate, Tris, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 2.80 Å R-free 0.268 |
| 1QUN X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI Deposited 1999-07-01 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 8 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain P
22–300（279 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；289 K；Ammonium Sulphate, Tris, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 2.80 Å R-free 0.268 |
| 1QUN X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI Deposited 1999-07-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 9 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain F
22–300（279 aa）
Chain N
22–300（279 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；289 K；Ammonium Sulphate, Tris, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 2.80 Å R-free 0.268 |
| 1TR7 FimH adhesin receptor binding domain from uropathogenic E. coli Deposited 2004-06-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
Fragment：N-terminal domain
|
Not recorded | DEG butyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；MPD, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.10 Å R-free 0.200 |
| 1TR7 FimH adhesin receptor binding domain from uropathogenic E. coli Deposited 2004-06-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
Fragment：N-terminal domain
|
Not recorded | DEG butyl alpha-D-mannopyranoside × 1 CAC CACODYLATE ION × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；MPD, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.10 Å R-free 0.200 |
| 1UWF 1.7 A resolution structure of the receptor binding domain of the FimH adhesin from uropathogenic E. coli Deposited 2004-02-05 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
Fragment：N-TERMINAL LECTIN DOMAIN, RESIDUES 22-179
|
Not recorded | DEG butyl alpha-D-mannopyranoside × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1.1 MM PROTEIN, 0.1 M HEPES PH 7.5, 10 % PEG6000, 5% V/V MPD
|
Resolution 1.69 Å R-free 0.218 |
| 1ZE3 Crystal Structure of the Ternary Complex of FIMD (N-Terminal Domain) with FIMC and the Pilin Domain of FIMH Deposited 2005-04-17 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain H
179–300（122 aa）
Fragment：FimH pilin domain
|
Not recorded | EDO 1,2-ETHANEDIOL × 12 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；PEG 6000, MES buffer, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 1.84 Å R-free 0.217 |
| 2VCO Crystal structure of the fimbrial adhesin FimH in complex with its high-mannose epitope Deposited 2007-09-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
22–179（158 aa）
Fragment：RECEPTOR-BINDING DOMAIN, RESIDUES 22-179
Chain B
22–179（158 aa）
Fragment：RECEPTOR-BINDING DOMAIN, RESIDUES 22-179
|
Not recorded | NI NICKEL (II) ION × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.5；1.0 M LI2SO4, 0.1 M TRIS-HCL PH 8.5, 0.01 M NICL2, 3% GLYCEROL
|
Resolution 2.10 Å R-free 0.241 |
| 3ZL1 A thiazolyl-mannoside bound to FimH, monoclinic space group Deposited 2013-01-27 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
Fragment：LECTIN DOMAIN OR RECEPTOR BINDING DOMAIN, RESIDUES 22-179
|
Not recorded | BWG N-{5-[(1R)-1-hydroxyethyl]-1,3-thiazol-2-yl}-alpha-D-mannopyranosylamine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；0.1 M NACL, 0.1 M TRIS PH 7.5, 11 % (W/V) PEG 4000
|
Resolution 1.55 Å R-free 0.262 |
| 3ZL1 A thiazolyl-mannoside bound to FimH, monoclinic space group Deposited 2013-01-27 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
Fragment：LECTIN DOMAIN OR RECEPTOR BINDING DOMAIN, RESIDUES 22-179
|
Not recorded | BWG N-{5-[(1R)-1-hydroxyethyl]-1,3-thiazol-2-yl}-alpha-D-mannopyranosylamine × 1 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；0.1 M NACL, 0.1 M TRIS PH 7.5, 11 % (W/V) PEG 4000
|
Resolution 1.55 Å R-free 0.262 |
| 3ZL2 A thiazolyl-mannoside bound to FimH, orthorhombic space group Deposited 2013-01-27 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
Fragment：LECTIN DOMAIN OR RECEPTOR BINDING DOMAIN, RESIDUES 22-179
|
Not recorded | BWG N-{5-[(1R)-1-hydroxyethyl]-1,3-thiazol-2-yl}-alpha-D-mannopyranosylamine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；20 MM NA/K PHOSPHATE, 0.1 M BIS TRIS PROPANE PH 6.5, 20 % (W/V) PEG 3350
|
Resolution 1.25 Å R-free 0.188 |
| 4CSS Crystal structure of FimH in complex with a sulfonamide biphenyl alpha D-mannoside Deposited 2014-03-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–180（159 aa）
Fragment：LECTIN DOMAIN, RESIDUES 22-180
|
Not recorded | CWX 4'-(alpha-D-Mannopyranosyloxy)-biphenyl-4-methyl sulfonamide × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.7；0.2 M SODIUM PHOSPHATE MONOBASIC MONOHYDRATE, 20% W/V PEG 3,350, pH 4.7
|
Resolution 1.07 Å R-free 0.132 |
| 4CST Crystal structure of FimH in complex with 3'-Chloro-4'-(alpha-D-mannopyranosyloxy)-biphenyl-4-carbonitrile Deposited 2014-03-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–180（159 aa）
Fragment：LECTIN DOMAIN, RESIDUES 22-180
|
Not recorded | CWK 3'-chloro-4'-(alpha-D-mannopyranosyloxy)biphenyl-4-carbonitrile × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
2.0 M AMMONIUM SULFATE, 0.1 M HEPES 7.5
|
Resolution 1.10 Å R-free 0.130 |
| 4J3O Crystal structure of the FimD usher traversed by the pilus tip complex assembly composed of FimC:FimF:FimG:FimH Deposited 2013-02-06 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain H
22–300（279 aa）
Fragment：UNP residues 22-300
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；1.6-2.0M sodium formate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.80 Å R-free 0.299 |
| 4LOV Crystal structure of FimH in complex with Heptylmannoside Deposited 2013-07-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
Fragment：UNP residues 22-179
|
Not recorded | KGM heptyl alpha-D-mannopyranoside × 1 GOL GLYCEROL × 1 NA SODIUM ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å R-free 0.190 |
| 4X50 Crystal structure of FimH in complex with biphenyl alpha-D-mannopyranoside Deposited 2014-12-04 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–180（159 aa）
|
Not recorded | 3X8 biphenyl-4-yl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；19% PEG 8000, 0.2 M (NH4)2SO4, 0.1 M HEPES pH 7.0.
|
Resolution 2.00 Å R-free 0.202 |
| 4X50 Crystal structure of FimH in complex with biphenyl alpha-D-mannopyranoside Deposited 2014-12-04 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–180（159 aa）
|
Not recorded | 3X8 biphenyl-4-yl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；19% PEG 8000, 0.2 M (NH4)2SO4, 0.1 M HEPES pH 7.0.
|
Resolution 2.00 Å R-free 0.202 |
| 4X5P Crystal structure of FimH in complex with a benzoyl-amidophenyl alpha-D-mannopyranoside Deposited 2014-12-05 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–180（159 aa）
Fragment：UNP residues 22-180
|
Not recorded | 3XJ 4-{[3-chloro-4-(alpha-D-mannopyranosyloxy)phenyl]carbamoyl}benzoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.7；293 K；20% PEG4000, 0.2 M NaH2PO4, pH 4.7
|
Resolution 1.00 Å R-free 0.139 |
| 4X5Q Crystal structure of FimH in complex with 5-nitro-indolinylphenyl alpha-D-mannopyranoside Deposited 2014-12-05 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–180（159 aa）
Fragment：UNP residues 22-180
|
Not recorded | 3XN 4-(5-nitro-1H-indol-1-yl)phenyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.7；293 K；20% PEG 3,350, 0.2 M sodium phosphate monobasic monohydrate
|
Resolution 1.12 Å R-free 0.129 |
| 4X5R Crystal structure of FimH in complex with a squaryl-phenyl alpha-D-mannopyranoside derivative Deposited 2014-12-05 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: Monomeric |
Chain A
22–180（159 aa）
Fragment：UNP residues 22-180
|
Not recorded | 3XO 2-chloro-4-{[2-(4-methylpiperazin-1-yl)-3,4-dioxocyclobut-1-en-1-yl]amino}phenyl alpha-D-mannopyranoside × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；277 K；1.5 M Ammonium sulfate, 0.1 M HEPES pH 7.0
|
Resolution 1.65 Å R-free 0.204 |
| 4X5R Crystal structure of FimH in complex with a squaryl-phenyl alpha-D-mannopyranoside derivative Deposited 2014-12-05 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: Monomeric |
Chain B
22–180（159 aa）
Fragment：UNP residues 22-180
|
Not recorded | 3XO 2-chloro-4-{[2-(4-methylpiperazin-1-yl)-3,4-dioxocyclobut-1-en-1-yl]amino}phenyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；277 K；1.5 M Ammonium sulfate, 0.1 M HEPES pH 7.0
|
Resolution 1.65 Å R-free 0.204 |
| 4X5R Crystal structure of FimH in complex with a squaryl-phenyl alpha-D-mannopyranoside derivative Deposited 2014-12-05 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: Monomeric |
Chain C
22–180（159 aa）
Fragment：UNP residues 22-180
|
Not recorded | 3XO 2-chloro-4-{[2-(4-methylpiperazin-1-yl)-3,4-dioxocyclobut-1-en-1-yl]amino}phenyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；277 K；1.5 M Ammonium sulfate, 0.1 M HEPES pH 7.0
|
Resolution 1.65 Å R-free 0.204 |
| 4XO8 Crystal structure of the FimH lectin domain from E.coli K12 in complex with heptyl alpha-D-mannopyrannoside Deposited 2015-01-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
Fragment：lectin domain, UNP residues 22-179
|
Not recorded | KGM heptyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；1.5 M (NH4)2SO4, 0.2 M Na Acetate pH 5.5
|
Resolution 1.70 Å R-free 0.195 |
| 4XO8 Crystal structure of the FimH lectin domain from E.coli K12 in complex with heptyl alpha-D-mannopyrannoside Deposited 2015-01-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
Fragment：lectin domain, UNP residues 22-179
|
Not recorded | KGM heptyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；1.5 M (NH4)2SO4, 0.2 M Na Acetate pH 5.5
|
Resolution 1.70 Å R-free 0.195 |
| 4XO9 Crystal structure of a FimH*DsG complex from E.coli K12 in space group C2 Deposited 2015-01-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
22–300（279 aa）
Fragment：UNP residues 22-300
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；278 K；25 % (w/v) polyethylene glycol (PEG) 3350, 0.2 M magnesium chloride, 0.1 M BisTris-HCl pH 5.5
|
Resolution 1.14 Å R-free 0.143 |
| 4XOA Crystal structure of a FimH*DsG complex from E.coli K12 in space group P1 Deposited 2015-01-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
22–300（279 aa）
Fragment：UNP residues 22-300
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；0.2M Na Malonate, 20%PEG3350
|
Resolution 2.54 Å R-free 0.260 |
| 4XOA Crystal structure of a FimH*DsG complex from E.coli K12 in space group P1 Deposited 2015-01-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain G
22–300（279 aa）
Fragment：UNP residues 22-300
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；0.2M Na Malonate, 20%PEG3350
|
Resolution 2.54 Å R-free 0.260 |
| 4XOA Crystal structure of a FimH*DsG complex from E.coli K12 in space group P1 Deposited 2015-01-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
22–300（279 aa）
Fragment：UNP residues 22-300
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；0.2M Na Malonate, 20%PEG3350
|
Resolution 2.54 Å R-free 0.260 |
| 4XOA Crystal structure of a FimH*DsG complex from E.coli K12 in space group P1 Deposited 2015-01-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
22–300（279 aa）
Fragment：UNP residues 22-300
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；0.2M Na Malonate, 20%PEG3350
|
Resolution 2.54 Å R-free 0.260 |
| 4XOB Crystal structure of a FimH*DsF complex from E.coli K12 with bound heptyl alpha-D-mannopyrannoside Deposited 2015-01-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
22–300（279 aa）
Fragment：UNP residues 22-300
|
Not recorded | KGM heptyl alpha-D-mannopyranoside × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；30 % w/v PEG 5,000, 0.1 M MES monohydrate, 0.2 M Ammonium sulfate pH 6.5. 2.5fold excess ligand to protein
|
Resolution 3.00 Å R-free 0.245 |
| 4XOB Crystal structure of a FimH*DsF complex from E.coli K12 with bound heptyl alpha-D-mannopyrannoside Deposited 2015-01-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
22–300（279 aa）
Fragment：UNP residues 22-300
|
Not recorded | KGM heptyl alpha-D-mannopyranoside × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；30 % w/v PEG 5,000, 0.1 M MES monohydrate, 0.2 M Ammonium sulfate pH 6.5. 2.5fold excess ligand to protein
|
Resolution 3.00 Å R-free 0.245 |
| 4XOB Crystal structure of a FimH*DsF complex from E.coli K12 with bound heptyl alpha-D-mannopyrannoside Deposited 2015-01-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
22–300（279 aa）
Fragment：UNP residues 22-300
|
Not recorded | KGM heptyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；30 % w/v PEG 5,000, 0.1 M MES monohydrate, 0.2 M Ammonium sulfate pH 6.5. 2.5fold excess ligand to protein
|
Resolution 3.00 Å R-free 0.245 |
| 4XOB Crystal structure of a FimH*DsF complex from E.coli K12 with bound heptyl alpha-D-mannopyrannoside Deposited 2015-01-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain G
22–300（279 aa）
Fragment：UNP residues 22-300
|
Not recorded | KGM heptyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；30 % w/v PEG 5,000, 0.1 M MES monohydrate, 0.2 M Ammonium sulfate pH 6.5. 2.5fold excess ligand to protein
|
Resolution 3.00 Å R-free 0.245 |
| 5ABZ Complex of the FimH lectin with a C-linked naphtyl alpha-D-mannoside in soaked trigonal crystals at 2.40 A resolution Deposited 2015-08-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
Fragment：LECTIN DOMAIN, UNP RESIDUES 22-179
|
Not recorded | Z47 (2R,3S,4R,5S,6R)-2-(HYDROXYMETHYL)-6-[3-(NAPHTHALEN-1-YL)PROPYL]OXANE-3,4,5-TRIOL × 1 NI NICKEL (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.6；PH 8.6
|
Resolution 2.40 Å R-free 0.206 |
| 5ABZ Complex of the FimH lectin with a C-linked naphtyl alpha-D-mannoside in soaked trigonal crystals at 2.40 A resolution Deposited 2015-08-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
Fragment：LECTIN DOMAIN, UNP RESIDUES 22-179
|
Not recorded | Z47 (2R,3S,4R,5S,6R)-2-(HYDROXYMETHYL)-6-[3-(NAPHTHALEN-1-YL)PROPYL]OXANE-3,4,5-TRIOL × 1 NI NICKEL (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.6；PH 8.6
|
Resolution 2.40 Å R-free 0.206 |
| 5CGB Crystal structure of FimH in complex with heptyl alpha-D-septanoside Deposited 2015-07-09 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | 51C (6R)-1,6-anhydro-2-O-heptyl-6-(hydroxymethyl)-D-galactitol × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；277 K；1.5 M NH4SO4, 0.1 M BisTris pH 5.5
|
Resolution 1.60 Å R-free 0.179 |
| 5CGB Crystal structure of FimH in complex with heptyl alpha-D-septanoside Deposited 2015-07-09 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | 51C (6R)-1,6-anhydro-2-O-heptyl-6-(hydroxymethyl)-D-galactitol × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；277 K；1.5 M NH4SO4, 0.1 M BisTris pH 5.5
|
Resolution 1.60 Å R-free 0.179 |
| 5F2F Crystal structure of para-biphenyl-2-methyl-3', 5' di-methyl amide mannoside bound to FimH lectin domain Deposited 2015-12-01 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
Fragment：lectin domain (UNP residues 22-179)
|
Not recorded | 5U7 5-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}1,~{N}3-dimethyl-benzene-1,3-dicarboxamide × 1 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.8；291 K；0.2 M AmSO4, 20% PEG3350
|
Resolution 1.67 Å R-free 0.177 |
| 5F3F Crystal structure of para-biphenyl-2-methyl-3'-methyl amide mannoside bound to FimH lectin domain Deposited 2015-12-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
Fragment：lectin domain (UNP residues 22-179)
|
Not recorded | 5US 3-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}-methyl-benzamide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.8；291 K；0.2 M AmSO4, 20% PEG 3350
|
Resolution 1.76 Å R-free 0.172 |
| 5JCQ Crystal structure of the FimH lectin domain from E.coli K12 in complex with methyl alpha-D-mannopyrannoside in spacegroup P21 Deposited 2016-04-15 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | MMA methyl alpha-D-mannopyranoside × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M Ammoniumsulfat, 30% PEG3350, 0.1 M Hepes 7.0, frozen by addition of 20 % EG
|
Resolution 1.60 Å R-free 0.214 |
| 5JCQ Crystal structure of the FimH lectin domain from E.coli K12 in complex with methyl alpha-D-mannopyrannoside in spacegroup P21 Deposited 2016-04-15 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | MMA methyl alpha-D-mannopyranoside × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M Ammoniumsulfat, 30% PEG3350, 0.1 M Hepes 7.0, frozen by addition of 20 % EG
|
Resolution 1.60 Å R-free 0.214 |
| 5JCR Crystal structure of the FimH lectin domain from E.coli K12 in complex with methyl alpha-D-mannopyrannoside in spacegroup P212121 Deposited 2016-04-15 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | MMA methyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M Ammoniumsulfat, 30% PEG3350, 0.1 M Hepes 7.0, frozen by addition of 20 % EG
|
Resolution 1.70 Å R-free 0.230 |
| 5JCR Crystal structure of the FimH lectin domain from E.coli K12 in complex with methyl alpha-D-mannopyrannoside in spacegroup P212121 Deposited 2016-04-15 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | MMA methyl alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M Ammoniumsulfat, 30% PEG3350, 0.1 M Hepes 7.0, frozen by addition of 20 % EG
|
Resolution 1.70 Å R-free 0.230 |
| 5L4T Crystal structure of FimH lectin domain in complex with 2-Deoxy-Heptylmannoside Deposited 2016-05-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | 6LS heptyl 2-deoxy-alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；285 K；0.2 M (NH4)2SO4, 0.1 M Hepes pH 7 and 25-30% PEG3350
|
Resolution 1.90 Å R-free 0.218 |
| 5L4T Crystal structure of FimH lectin domain in complex with 2-Deoxy-Heptylmannoside Deposited 2016-05-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | 6LS heptyl 2-deoxy-alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；285 K；0.2 M (NH4)2SO4, 0.1 M Hepes pH 7 and 25-30% PEG3350
|
Resolution 1.90 Å R-free 0.218 |
| 5L4U Crystal structure of FimH lectin domain in complex with 2-Fluoro-Heptylmannoside Deposited 2016-05-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | 6KS heptyl 2-fluoro-alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；285 K；0.2 M (NH4)2SO4, 0.1 M Hepes pH 7 and 25-30% PEG3350
|
Resolution 2.10 Å R-free 0.236 |
| 5L4U Crystal structure of FimH lectin domain in complex with 2-Fluoro-Heptylmannoside Deposited 2016-05-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | 6KS heptyl 2-fluoro-alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；285 K；0.2 M (NH4)2SO4, 0.1 M Hepes pH 7 and 25-30% PEG3350
|
Resolution 2.10 Å R-free 0.236 |
| 5L4V Crystal structure of FimH lectin domain in complex with 3-Deoxy-Heptylmannoside Deposited 2016-05-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | 6KW heptyl 3-deoxy-alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；285 K；0.2 M (NH4)2SO4, 0.1 M Hepes pH 7 and 25-30% PEG3350
|
Resolution 2.99 Å R-free 0.252 |
| 5L4V Crystal structure of FimH lectin domain in complex with 3-Deoxy-Heptylmannoside Deposited 2016-05-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | 6KW heptyl 3-deoxy-alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；285 K；0.2 M (NH4)2SO4, 0.1 M Hepes pH 7 and 25-30% PEG3350
|
Resolution 2.99 Å R-free 0.252 |
| 5L4V Crystal structure of FimH lectin domain in complex with 3-Deoxy-Heptylmannoside Deposited 2016-05-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
22–179（158 aa）
|
Not recorded | 6KW heptyl 3-deoxy-alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；285 K；0.2 M (NH4)2SO4, 0.1 M Hepes pH 7 and 25-30% PEG3350
|
Resolution 2.99 Å R-free 0.252 |
| 5L4W Crystal structure of FimH lectin domain in complex with 3-Fluoro-Heptylmannoside Deposited 2016-05-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | 6KH heptyl 3-fluoro-alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；285 K；0.2 M (NH4)2SO4, 0.1 M Hepes pH 7 and 25-30% PEG3350
|
Resolution 1.90 Å R-free 0.202 |
| 5L4W Crystal structure of FimH lectin domain in complex with 3-Fluoro-Heptylmannoside Deposited 2016-05-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | 6KH heptyl 3-fluoro-alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；285 K；0.2 M (NH4)2SO4, 0.1 M Hepes pH 7 and 25-30% PEG3350
|
Resolution 1.90 Å R-free 0.202 |
| 5L4W Crystal structure of FimH lectin domain in complex with 3-Fluoro-Heptylmannoside Deposited 2016-05-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
22–179（158 aa）
|
Not recorded | 6KH heptyl 3-fluoro-alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；285 K；0.2 M (NH4)2SO4, 0.1 M Hepes pH 7 and 25-30% PEG3350
|
Resolution 1.90 Å R-free 0.202 |
| 5L4X Crystal structure of FimH lectin domain in complex with 4-Deoxy-Heptylmannoside Deposited 2016-05-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | 6KU heptyl 4-deoxy-4-deoxy-alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；285 K；0.2 M (NH4)2SO4, 0.1 M Hepes pH 7 and 25-30% PEG3350
|
Resolution 1.90 Å R-free 0.204 |
| 5L4X Crystal structure of FimH lectin domain in complex with 4-Deoxy-Heptylmannoside Deposited 2016-05-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | 6KU heptyl 4-deoxy-4-deoxy-alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；285 K；0.2 M (NH4)2SO4, 0.1 M Hepes pH 7 and 25-30% PEG3350
|
Resolution 1.90 Å R-free 0.204 |
| 5L4Y Crystal structure of FimH lectin domain in complex with 4-Fluoro-Heptylmannoside Deposited 2016-05-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | 6K3 heptyl 4-deoxy-4-fluoro-alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；285 K；0.2 M (NH4)2SO4, 0.1 M Hepes pH 7 and 25-30% PEG3350
|
Resolution 1.90 Å R-free 0.229 |
| 5L4Y Crystal structure of FimH lectin domain in complex with 4-Fluoro-Heptylmannoside Deposited 2016-05-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | 6K3 heptyl 4-deoxy-4-fluoro-alpha-D-mannopyranoside × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；285 K；0.2 M (NH4)2SO4, 0.1 M Hepes pH 7 and 25-30% PEG3350
|
Resolution 1.90 Å R-free 0.229 |
| 5MCA Crystal structure of FimH-LD R60P variant in the apo state Deposited 2016-11-09 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–180（159 aa）
|
Mutation：R60P | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；1.5 M (NH4)2SO4, 0.1M BisTris 6.5
|
Resolution 1.60 Å R-free 0.175 |
| 5MTS Complex of FimH lectin with a TazMan (thiazolylaminomannosides) family member known as potent anti-adhesive agent at 2.6 A resolution Deposited 2017-01-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–300（300 aa）
|
Not recorded | XKA [2-[[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]amino]-1,3-thiazol-5-yl]-(4-methyl-2-pyrazin-2-yl-1,3-thiazol-5-yl)methanone × 1 NI NICKEL (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；300 K；1.0 M LI2SO4
0.1 M TRIS-HCL
0.01 M NICL2
3% GLYCEROL
|
Resolution 2.60 Å R-free 0.250 |
| 5MTS Complex of FimH lectin with a TazMan (thiazolylaminomannosides) family member known as potent anti-adhesive agent at 2.6 A resolution Deposited 2017-01-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
1–300（300 aa）
|
Not recorded | XKA [2-[[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]amino]-1,3-thiazol-5-yl]-(4-methyl-2-pyrazin-2-yl-1,3-thiazol-5-yl)methanone × 1 NI NICKEL (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；300 K；1.0 M LI2SO4
0.1 M TRIS-HCL
0.01 M NICL2
3% GLYCEROL
|
Resolution 2.60 Å R-free 0.250 |
| 5MUC Crystal structure of the FimH lectin domain in complex with 1,5-Anhydromannitol Deposited 2017-01-13 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | AH2 1-deoxy-alpha-D-mannopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；1.6 M Ammoniumsulfat, 0.1 M Hepes 7.5, 1% PEG3350
|
Resolution 2.60 Å R-free 0.260 |
| 5MUC Crystal structure of the FimH lectin domain in complex with 1,5-Anhydromannitol Deposited 2017-01-13 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | AH2 1-deoxy-alpha-D-mannopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；1.6 M Ammoniumsulfat, 0.1 M Hepes 7.5, 1% PEG3350
|
Resolution 2.60 Å R-free 0.260 |
| 6E14 Handover mechanism of the growing pilus by the bacterial outer membrane usher FimD Deposited 2018-07-09 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain H
1–300（300 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.00 Å |
| 6E15 Handover mechanism of the growing pilus by the bacterial outer membrane usher FimD Deposited 2018-07-09 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain H
1–300（300 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 5.10 Å |
| 6G2R Crystal structure of FimH in complex with a tetraflourinated biphenyl alpha D-mannoside Deposited 2018-03-23 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | EJK 4-[3-chloranyl-4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-phenyl]-2,3,5,6-tetrakis(fluoranyl)benzenecarbonitrile × 1 SO4 SULFATE ION × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M NaAcetate pH 5.0, 1.5 M NH4sulfate
|
Resolution 2.10 Å R-free 0.222 |
| 6G2R Crystal structure of FimH in complex with a tetraflourinated biphenyl alpha D-mannoside Deposited 2018-03-23 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | EJK 4-[3-chloranyl-4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-phenyl]-2,3,5,6-tetrakis(fluoranyl)benzenecarbonitrile × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M NaAcetate pH 5.0, 1.5 M NH4sulfate
|
Resolution 2.10 Å R-free 0.222 |
| 6GTX Crystal structure of the FimH lectin domain from E.coli K12 in complex with the dimannoside Man(alpha1-2)Man Deposited 2018-06-19 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；1.5 M (NH4)2SO4, 0.1 M BisTris-HCl pH 5.5
|
Resolution 2.50 Å R-free 0.240 |
| 6GTX Crystal structure of the FimH lectin domain from E.coli K12 in complex with the dimannoside Man(alpha1-2)Man Deposited 2018-06-19 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；1.5 M (NH4)2SO4, 0.1 M BisTris-HCl pH 5.5
|
Resolution 2.50 Å R-free 0.240 |
| 6GTX Crystal structure of the FimH lectin domain from E.coli K12 in complex with the dimannoside Man(alpha1-2)Man Deposited 2018-06-19 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
22–179（158 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；1.5 M (NH4)2SO4, 0.1 M BisTris-HCl pH 5.5
|
Resolution 2.50 Å R-free 0.240 |
| 6GTX Crystal structure of the FimH lectin domain from E.coli K12 in complex with the dimannoside Man(alpha1-2)Man Deposited 2018-06-19 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
22–179（158 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；1.5 M (NH4)2SO4, 0.1 M BisTris-HCl pH 5.5
|
Resolution 2.50 Å R-free 0.240 |
| 6GTY Crystal structure of the FimH lectin domain from E.coli K12 in complex with the dimannoside Man(alpha1-6)Man Deposited 2018-06-19 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.1 M ammonium sulfate, 0.3 M sodium formate, 0.1 M Tris pH 7.8, 3% w/v PGA-LM, 30% w/v PGA-LM PEG20K
|
Resolution 1.90 Å R-free 0.216 |
| 6GTY Crystal structure of the FimH lectin domain from E.coli K12 in complex with the dimannoside Man(alpha1-6)Man Deposited 2018-06-19 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.1 M ammonium sulfate, 0.3 M sodium formate, 0.1 M Tris pH 7.8, 3% w/v PGA-LM, 30% w/v PGA-LM PEG20K
|
Resolution 1.90 Å R-free 0.216 |
| 6GTY Crystal structure of the FimH lectin domain from E.coli K12 in complex with the dimannoside Man(alpha1-6)Man Deposited 2018-06-19 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
22–179（158 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.1 M ammonium sulfate, 0.3 M sodium formate, 0.1 M Tris pH 7.8, 3% w/v PGA-LM, 30% w/v PGA-LM PEG20K
|
Resolution 1.90 Å R-free 0.216 |
| 6GTY Crystal structure of the FimH lectin domain from E.coli K12 in complex with the dimannoside Man(alpha1-6)Man Deposited 2018-06-19 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
22–179（158 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.1 M ammonium sulfate, 0.3 M sodium formate, 0.1 M Tris pH 7.8, 3% w/v PGA-LM, 30% w/v PGA-LM PEG20K
|
Resolution 1.90 Å R-free 0.216 |
| 6GTY Crystal structure of the FimH lectin domain from E.coli K12 in complex with the dimannoside Man(alpha1-6)Man Deposited 2018-06-19 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain E
22–179（158 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.1 M ammonium sulfate, 0.3 M sodium formate, 0.1 M Tris pH 7.8, 3% w/v PGA-LM, 30% w/v PGA-LM PEG20K
|
Resolution 1.90 Å R-free 0.216 |
| 7AYN Crystal structure of the lectin domain of the FimH variant Arg98Ala, in complex with Methyl 3-chloro-4-D-mannopyranosyloxy-3-biphenylcarboxylate Deposited 2020-11-12 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | SBQ methyl 3-[3-chloranyl-4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-phenyl]benzoate × 1 EDO 1,2-ETHANEDIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；6% Tacsimate pH 6.0, 12% PEG3350
|
Resolution 1.42 Å R-free 0.184 |
| 7AYN Crystal structure of the lectin domain of the FimH variant Arg98Ala, in complex with Methyl 3-chloro-4-D-mannopyranosyloxy-3-biphenylcarboxylate Deposited 2020-11-12 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | SBQ methyl 3-[3-chloranyl-4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-phenyl]benzoate × 1 EDO 1,2-ETHANEDIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；6% Tacsimate pH 6.0, 12% PEG3350
|
Resolution 1.42 Å R-free 0.184 |
| 7AYN Crystal structure of the lectin domain of the FimH variant Arg98Ala, in complex with Methyl 3-chloro-4-D-mannopyranosyloxy-3-biphenylcarboxylate Deposited 2020-11-12 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
22–179（158 aa）
|
Not recorded | SBQ methyl 3-[3-chloranyl-4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-phenyl]benzoate × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；6% Tacsimate pH 6.0, 12% PEG3350
|
Resolution 1.42 Å R-free 0.184 |
| 7AYN Crystal structure of the lectin domain of the FimH variant Arg98Ala, in complex with Methyl 3-chloro-4-D-mannopyranosyloxy-3-biphenylcarboxylate Deposited 2020-11-12 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
22–179（158 aa）
|
Not recorded | SBQ methyl 3-[3-chloranyl-4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-phenyl]benzoate × 1 EDO 1,2-ETHANEDIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；6% Tacsimate pH 6.0, 12% PEG3350
|
Resolution 1.42 Å R-free 0.184 |
| 7BHD FimH in complex with alpha1,6 core-fucosylated oligomannose-3, crystallized in the trigonal space group Deposited 2021-01-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
22–179（158 aa）
Chain B
22–179（158 aa）
|
Not recorded | NI NICKEL (II) ION × 2 SO4 SULFATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9；291 K；1,1M Lithium sulfate, 0,1M Tris-HCl pH=9, 0,01M Nickel Chloride
|
Resolution 1.40 Å R-free 0.198 |
| 8BVD FimH lectin domain in complex with mannose C-linked to quinoline Deposited 2022-12-03 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | RLO (2R,3S,4R,5S,6R)-2-(hydroxymethyl)-6-[(E)-3-quinolin-6-ylprop-2-enyl]oxane-3,4,5-triol × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293.15 K；3.0M NaCl and 0.1M BIS-TRIS at pH=5.5
|
Resolution 3.00 Å R-free 0.303 |
| 8BVD FimH lectin domain in complex with mannose C-linked to quinoline Deposited 2022-12-03 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | RLO (2R,3S,4R,5S,6R)-2-(hydroxymethyl)-6-[(E)-3-quinolin-6-ylprop-2-enyl]oxane-3,4,5-triol × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293.15 K；3.0M NaCl and 0.1M BIS-TRIS at pH=5.5
|
Resolution 3.00 Å R-free 0.303 |
| 8BVD FimH lectin domain in complex with mannose C-linked to quinoline Deposited 2022-12-03 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
22–179（158 aa）
|
Not recorded | RLO (2R,3S,4R,5S,6R)-2-(hydroxymethyl)-6-[(E)-3-quinolin-6-ylprop-2-enyl]oxane-3,4,5-triol × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293.15 K；3.0M NaCl and 0.1M BIS-TRIS at pH=5.5
|
Resolution 3.00 Å R-free 0.303 |
| 8BVD FimH lectin domain in complex with mannose C-linked to quinoline Deposited 2022-12-03 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
22–179（158 aa）
|
Not recorded | RLO (2R,3S,4R,5S,6R)-2-(hydroxymethyl)-6-[(E)-3-quinolin-6-ylprop-2-enyl]oxane-3,4,5-triol × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293.15 K；3.0M NaCl and 0.1M BIS-TRIS at pH=5.5
|
Resolution 3.00 Å R-free 0.303 |
| 8BXY FimH in complex with alpha1,6 core-fucosylated oligomannose-3, crystallized in the trigonal space group Deposited 2022-12-11 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–179（158 aa）
|
Not recorded | NI NICKEL (II) ION × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9；291 K；1.1 M Lithium sulphate; 0.1 M Tris-HCl pH 9.0; 10 mM nickel chloride
|
Resolution 1.45 Å R-free 0.205 |
| 8BXY FimH in complex with alpha1,6 core-fucosylated oligomannose-3, crystallized in the trigonal space group Deposited 2022-12-11 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–179（158 aa）
|
Not recorded | NI NICKEL (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9；291 K；1.1 M Lithium sulphate; 0.1 M Tris-HCl pH 9.0; 10 mM nickel chloride
|
Resolution 1.45 Å R-free 0.205 |
| 8BY3 FimH lectin domain in complex with oligomannose-6 Deposited 2022-12-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
22–179（158 aa）
Chain C
22–179（158 aa）
|
Not recorded | NI NICKEL (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；1 M Lithium sulphate
100 mM Tris-HCl, pH 8.5
10 mM Nickel chloride
3% glycerol
|
Resolution 3.19 Å R-free 0.238 |
| 8BY3 FimH lectin domain in complex with oligomannose-6 Deposited 2022-12-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
22–179（158 aa）
Chain D
22–179（158 aa）
|
Not recorded | NI NICKEL (II) ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；1 M Lithium sulphate
100 mM Tris-HCl, pH 8.5
10 mM Nickel chloride
3% glycerol
|
Resolution 3.19 Å R-free 0.238 |
| 8V3J Structure-Based Engineering of a Highly Immunogenic, Conformationally Stabilized FimH Antigen for a Urinary Tract Infection Vaccine Deposited 2023-11-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–300（279 aa）
|
Mutation：N7S,G15A,G16A,V27A,N70S,N228Q | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.1 M Sodium Acetate (pH 4.5), 25% (w/v) PEG 3350
|
Resolution 1.90 Å R-free 0.238 |
| 8V3J Structure-Based Engineering of a Highly Immunogenic, Conformationally Stabilized FimH Antigen for a Urinary Tract Infection Vaccine Deposited 2023-11-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
22–300（279 aa）
|
Mutation：N7S,G15A,G16A,V27A,N70S,N228Q | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.1 M Sodium Acetate (pH 4.5), 25% (w/v) PEG 3350
|
Resolution 1.90 Å R-free 0.238 |
| 8V3J Structure-Based Engineering of a Highly Immunogenic, Conformationally Stabilized FimH Antigen for a Urinary Tract Infection Vaccine Deposited 2023-11-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
22–300（279 aa）
|
Mutation：N7S,G15A,G16A,V27A,N70S,N228Q | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.1 M Sodium Acetate (pH 4.5), 25% (w/v) PEG 3350
|
Resolution 1.90 Å R-free 0.238 |
| 8V3J Structure-Based Engineering of a Highly Immunogenic, Conformationally Stabilized FimH Antigen for a Urinary Tract Infection Vaccine Deposited 2023-11-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
22–300（279 aa）
|
Mutation：N7S,G15A,G16A,V27A,N70S,N228Q | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.1 M Sodium Acetate (pH 4.5), 25% (w/v) PEG 3350
|
Resolution 1.90 Å R-free 0.238 |
| 8V93 Cryo-EM structure of E. coli FimH lectin domain bound to Fabs 329-2 and 454-3 Deposited 2023-12-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric |
Chain D
22–300（279 aa）
|
Mutation：N7S, G15A, G16A, V27A, N70S, N228Q within FimH | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.12 Å |
| 9BOG Structural basis for adhesin secretion by the outer-membrane usher in type 1 pili Deposited 2024-05-03 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain H
22–300（279 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.99 Å |
| 9D6F Cryo-EM structure of E. coli FimH lectin domain bound to Fabs 440-2 and 454-3 Deposited 2024-08-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric |
Chain D
22–300（279 aa）
|
Mutation：N7S, G15A, G16A, V27A, N70S, N228Q within FimH | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.24 Å |
| 9FY9 Cryo-EM structure of the type 1 chaperone-usher pilus FimD-tip complex (FimDHGFC) - Conformer 1 Deposited 2024-07-03 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain H
22–300（279 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE
|
Resolution 3.30 Å |
| 9ME4 Antibody fragments from mAb475 and mAb824 bound to the adhesin protein FimH Deposited 2024-12-06 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
1–300（300 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9ME5 Antibody fragments from mAb824 and mAb926 bound to the adhesin protein FimH Deposited 2024-12-06 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
1–300（300 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9ME6 Antibody fragments from mAb21, mAb475, and mAb824 bound to the adhesin protein FimH Deposited 2024-12-06 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric |
Chain A
1–300（300 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9ME7 Antibody fragments from mAb21 and mAb824 bound to the adhesin protein FimH containing alpha-methyl mannose Deposited 2024-12-06 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain A
1–300（300 aa）
|
Not recorded | MMA methyl alpha-D-mannopyranoside × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9PTM Antibody fragment from mAb824 bound to the adhesin protein FimH. Deposited 2025-07-29 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–300（300 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 9Q1V Crystal Structure of de novo design FimH minibinder F7 complex Deposited 2025-08-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
22–181（160 aa）
|
Mutation：L34K | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.2 M sodium malonate, pH 7.0, 20% w/v PEG3350
|
Resolution 1.75 Å R-free 0.263 |
| 9Q1V Crystal Structure of de novo design FimH minibinder F7 complex Deposited 2025-08-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
22–181（160 aa）
|
Mutation：L34K | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.2 M sodium malonate, pH 7.0, 20% w/v PEG3350
|
Resolution 1.75 Å R-free 0.263 |
57 other PDB entries and 130 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | FIMH_ECOLI |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–158； UniProt 22–179 Author chain B； PDBConstruct 1–158； UniProt 22–179 Author chain C； PDBConstruct 1–158； UniProt 22–179 Author chain D； PDBConstruct 1–158； UniProt 22–179 Author chain E； PDBConstruct 1–158； UniProt 22–179 Author chain F； PDBConstruct 1–158； UniProt 22–179 Author chain G； PDBConstruct 1–158； UniProt 22–179 Author chain H； PDBConstruct 1–158； UniProt 22–179 Author chain I； PDBConstruct 1–158； UniProt 22–179 |
