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6sof

human insulin receptor ectodomain bound by 4 insulin

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Insulin receptor

Homo sapiens

UniProt P06213

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 Insulin × 4 （P01308） Insulin × 4 （P01308） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1i44 1irk 1p14 2mfr 3ekk 3ekn 3eta 3eta 4ibm 4ibm 5e1s 5hhw

13 assemblies; showing the first 12

Homodimer
3eta 4xlv 8u4b

3 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1gag 1gag 1ir3 1rqq 2auh 2b4s 2hr7 2z8c 3bu3 3bu5 3bu6 3w11

84 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name INSR_HUMAN
Isoform P06213-2
PDB entities 1, 2
Chains and sequence ranges Author chain A； PDBConstruct 1–719； UniProt 28–746 Author chain C； PDBConstruct 1–719； UniProt 28–746 Author chain B； PDBConstruct 1–162； UniProt 783–944 Author chain D； PDBConstruct 1–162； UniProt 783–944

Insulin

Homo sapiens

UniProt P01308

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 Insulin receptor × 2 （P06213） Insulin receptor × 2 （P06213） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1efe 1sju 1t0c 2jzq 2kqp 2lwz 4efx 4efx 4efx 4efx 5wbt 8pi6

16 assemblies; showing the first 12

Homodimer
1a7f 1ben 1ben 1guj 1guj 1hiq 1his 1hit 1hls 1hui 1iog 1ioh

155 assemblies; showing the first 12

Homotetramer
1b9e 1b9e 1fub 1lph 1lph 1trz 1trz 1tyl 1tyl 1tym 1tym 1xda

69 assemblies; showing the first 12

Other homooligomers
1ai0 1aiy 1ben 1ben 1ben 1ben 1ben 1ben 1ben 1ben 1ben 1ben

244 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
2g54 2g54 2g56 2g56 2wby 2wby 2wc0 2wc0 3utq 3uts 3uts 3utt

100 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name INS_HUMAN
Isoform —
PDB entities 3, 4
Chains and sequence ranges Author chain E； PDBConstruct 1–21； UniProt 90–110 Author chain G； PDBConstruct 1–21； UniProt 90–110 Author chain I； PDBConstruct 1–21； UniProt 90–110 Author chain K； PDBConstruct 1–21； UniProt 90–110 Author chain F； PDBConstruct 1–30； UniProt 25–54 Author chain H； PDBConstruct 1–30； UniProt 25–54 Author chain J； PDBConstruct 1–30； UniProt 25–54 Author chain L； PDBConstruct 1–30； UniProt 25–54

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6sof
Deposition date deposition_date2019-08-29
Structure title titlehuman insulin receptor ectodomain bound by 4 insulin
Keywords keywordscell surface receptor, insulin, tyrosine kinase receptor, glucose homeostasis, hormone, diabetes, MEMBRANE PROTEIN; MEMBRANE PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6sof__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6sof__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6sof__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）50.53 Å
Rg (electron density)50.45 Å
Total Rg50.50 Å
Atom count30333
Residues1966
Excluded volume279080 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6sof__assembly_1__model_1 dodecameric （12） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (2)