7ktr

Cryo-EM structure of the human SAGA coactivator complex (TRRAP, core)

Method: ELECTRON MICROSCOPY
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

;Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein ;

物种未注明

UniProt F2Z2U4

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 11 TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L × 1 (O75529) Isoform 3 of Transcription factor SPT20 homolog × 1 (Q8NEM7) ;STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA ; × 1 (O94864) Transcription initiation factor TFIID subunit 9B × 1 (Q9HBM6) TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L × 1 (Q9Y6J9) Transcription initiation factor TFIID subunit 12 × 1 (Q16514) Transcription initiation factor TFIID subunit 10 × 1 (Q12962) ;Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog ; × 1 (O75486) Transcriptional adapter 1 × 1 (Q96BN2) Ataxin-7 × 1 (O15265) INOSITOL HEXAKISPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 F2Z2U4_HUMAN
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 18–1337; UniProt 369–1688 作者链 A; PDB构建体 1647–3195; UniProt 2300–3848

TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

物种未注明

UniProt O75529

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 11 ;Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein ; × 1 (F2Z2U4) Isoform 3 of Transcription factor SPT20 homolog × 1 (Q8NEM7) ;STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA ; × 1 (O94864) Transcription initiation factor TFIID subunit 9B × 1 (Q9HBM6) TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L × 1 (Q9Y6J9) Transcription initiation factor TFIID subunit 12 × 1 (Q16514) Transcription initiation factor TFIID subunit 10 × 1 (Q12962) ;Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog ; × 1 (O75486) Transcriptional adapter 1 × 1 (Q96BN2) Ataxin-7 × 1 (O15265) INOSITOL HEXAKISPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 TAF5L_HUMAN
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–589; UniProt 1–589

Isoform 3 of Transcription factor SPT20 homolog

物种未注明

UniProt Q8NEM7

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 11 ;Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein ; × 1 (F2Z2U4) TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L × 1 (O75529) ;STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA ; × 1 (O94864) Transcription initiation factor TFIID subunit 9B × 1 (Q9HBM6) TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L × 1 (Q9Y6J9) Transcription initiation factor TFIID subunit 12 × 1 (Q16514) Transcription initiation factor TFIID subunit 10 × 1 (Q12962) ;Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog ; × 1 (O75486) Transcriptional adapter 1 × 1 (Q96BN2) Ataxin-7 × 1 (O15265) INOSITOL HEXAKISPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 SP20H_HUMAN
Isoform Q8NEM7-3
PDB实体 3
链与序列区间 作者链 C; PDB构建体 1–811; UniProt 1–811

;STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA ;

unclassified Rhodococcus

UniProt O94864

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 11 ;Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein ; × 1 (F2Z2U4) TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L × 1 (O75529) Isoform 3 of Transcription factor SPT20 homolog × 1 (Q8NEM7) Transcription initiation factor TFIID subunit 9B × 1 (Q9HBM6) TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L × 1 (Q9Y6J9) Transcription initiation factor TFIID subunit 12 × 1 (Q16514) Transcription initiation factor TFIID subunit 10 × 1 (Q12962) ;Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog ; × 1 (O75486) Transcriptional adapter 1 × 1 (Q96BN2) Ataxin-7 × 1 (O15265) INOSITOL HEXAKISPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ST65G_HUMAN
Isoform —
PDB实体 4
链与序列区间 作者链 D; PDB构建体 16–51; UniProt 52–87 作者链 D; PDB构建体 74–369; UniProt 119–414

Transcription initiation factor TFIID subunit 9B

物种未注明

UniProt Q9HBM6

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 11 ;Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein ; × 1 (F2Z2U4) TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L × 1 (O75529) Isoform 3 of Transcription factor SPT20 homolog × 1 (Q8NEM7) ;STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA ; × 1 (O94864) TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L × 1 (Q9Y6J9) Transcription initiation factor TFIID subunit 12 × 1 (Q16514) Transcription initiation factor TFIID subunit 10 × 1 (Q12962) ;Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog ; × 1 (O75486) Transcriptional adapter 1 × 1 (Q96BN2) Ataxin-7 × 1 (O15265) INOSITOL HEXAKISPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 TAF9B_HUMAN
Isoform —
PDB实体 5
链与序列区间 作者链 E; PDB构建体 1–251; UniProt 1–251

TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

物种未注明

UniProt Q9Y6J9

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 11 ;Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein ; × 1 (F2Z2U4) TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L × 1 (O75529) Isoform 3 of Transcription factor SPT20 homolog × 1 (Q8NEM7) ;STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA ; × 1 (O94864) Transcription initiation factor TFIID subunit 9B × 1 (Q9HBM6) Transcription initiation factor TFIID subunit 12 × 1 (Q16514) Transcription initiation factor TFIID subunit 10 × 1 (Q12962) ;Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog ; × 1 (O75486) Transcriptional adapter 1 × 1 (Q96BN2) Ataxin-7 × 1 (O15265) INOSITOL HEXAKISPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 TAF6L_HUMAN
Isoform —
PDB实体 6
链与序列区间 作者链 F; PDB构建体 1–622; UniProt 1–622

Transcription initiation factor TFIID subunit 12

物种未注明

UniProt Q16514

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 11 ;Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein ; × 1 (F2Z2U4) TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L × 1 (O75529) Isoform 3 of Transcription factor SPT20 homolog × 1 (Q8NEM7) ;STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA ; × 1 (O94864) Transcription initiation factor TFIID subunit 9B × 1 (Q9HBM6) TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L × 1 (Q9Y6J9) Transcription initiation factor TFIID subunit 10 × 1 (Q12962) ;Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog ; × 1 (O75486) Transcriptional adapter 1 × 1 (Q96BN2) Ataxin-7 × 1 (O15265) INOSITOL HEXAKISPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 TAF12_HUMAN
Isoform —
PDB实体 7
链与序列区间 作者链 G; PDB构建体 1–161; UniProt 1–161

Transcription initiation factor TFIID subunit 10

物种未注明

UniProt Q12962

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 11 ;Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein ; × 1 (F2Z2U4) TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L × 1 (O75529) Isoform 3 of Transcription factor SPT20 homolog × 1 (Q8NEM7) ;STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA ; × 1 (O94864) Transcription initiation factor TFIID subunit 9B × 1 (Q9HBM6) TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L × 1 (Q9Y6J9) Transcription initiation factor TFIID subunit 12 × 1 (Q16514) ;Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog ; × 1 (O75486) Transcriptional adapter 1 × 1 (Q96BN2) Ataxin-7 × 1 (O15265) INOSITOL HEXAKISPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 TAF10_HUMAN
Isoform —
PDB实体 8
链与序列区间 作者链 H; PDB构建体 1–218; UniProt 1–218

;Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog ;

物种未注明

UniProt O75486

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 11 ;Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein ; × 1 (F2Z2U4) TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L × 1 (O75529) Isoform 3 of Transcription factor SPT20 homolog × 1 (Q8NEM7) ;STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA ; × 1 (O94864) Transcription initiation factor TFIID subunit 9B × 1 (Q9HBM6) TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L × 1 (Q9Y6J9) Transcription initiation factor TFIID subunit 12 × 1 (Q16514) Transcription initiation factor TFIID subunit 10 × 1 (Q12962) Transcriptional adapter 1 × 1 (Q96BN2) Ataxin-7 × 1 (O15265) INOSITOL HEXAKISPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 SUPT3_HUMAN
Isoform —
PDB实体 9
链与序列区间 作者链 I; PDB构建体 1–156; UniProt 1–156 作者链 I; PDB构建体 169–299; UniProt 187–317

Transcriptional adapter 1

物种未注明

UniProt Q96BN2

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 11 ;Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein ; × 1 (F2Z2U4) TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L × 1 (O75529) Isoform 3 of Transcription factor SPT20 homolog × 1 (Q8NEM7) ;STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA ; × 1 (O94864) Transcription initiation factor TFIID subunit 9B × 1 (Q9HBM6) TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L × 1 (Q9Y6J9) Transcription initiation factor TFIID subunit 12 × 1 (Q16514) Transcription initiation factor TFIID subunit 10 × 1 (Q12962) ;Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog ; × 1 (O75486) Ataxin-7 × 1 (O15265) INOSITOL HEXAKISPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 TADA1_HUMAN
Isoform —
PDB实体 10
链与序列区间 作者链 J; PDB构建体 1–335; UniProt 1–335

Ataxin-7

物种未注明

UniProt O15265

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 11 ;Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein ; × 1 (F2Z2U4) TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L × 1 (O75529) Isoform 3 of Transcription factor SPT20 homolog × 1 (Q8NEM7) ;STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA ; × 1 (O94864) Transcription initiation factor TFIID subunit 9B × 1 (Q9HBM6) TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L × 1 (Q9Y6J9) Transcription initiation factor TFIID subunit 12 × 1 (Q16514) Transcription initiation factor TFIID subunit 10 × 1 (Q12962) ;Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog ; × 1 (O75486) Transcriptional adapter 1 × 1 (Q96BN2) INOSITOL HEXAKISPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ATX7_HUMAN
Isoform —
PDB实体 11
链与序列区间 作者链 N; PDB构建体 1–892; UniProt 1–892

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id7ktr
沉积日期 deposition_date2020-11-24
结构标题 titleCryo-EM structure of the human SAGA coactivator complex (TRRAP, core)
关键词 keywordscoactivator, gene regulation, transcription, chromatin; TRANSCRIPTION
实验方法 methodELECTRON MICROSCOPY
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

7ktr__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

7ktr__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

7ktr__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)64.28 Å
Rg(电子密度)64.05 Å
总 Rg64.04 Å
原子数79321
残基数5168
排除体积717350 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 7ktr__assembly_1__model_1 undecameric (11) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (12)

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6. 折叠分类 (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

结构域编号 domain_id7ktrB01
类 Class class1 — Mainly Alpha
架构 Architecture architecture25 — Alpha Horseshoe
拓扑 Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
同源超家族 H-superfamily homologous superfamily500 — TFIID subunit TAF5, NTD2 domain
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7. 引用文献 (1)