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8dd0

The structure of the native cardiac thin filament junction region

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Actin, alpha cardiac muscle 1

OrganismNot specified

UniProt B6VNT8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 16 Tropomyosin alpha-1 chain × 8 （P42639） Troponin T2, cardiac type × 2 （I3LS66） ADENOSINE-5'-DIPHOSPHATE × 6 MAGNESIUM ION × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5nog 5nol 7jh7 7lrg 8dd0 8efh 8efi 8enc 8uww 8uwx 8uwy 8uyd

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name B6VNT8_PIG
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–377； UniProt 1–377 Author chain B； PDBConstruct 1–377； UniProt 1–377 Author chain C； PDBConstruct 1–377； UniProt 1–377 Author chain D； PDBConstruct 1–377； UniProt 1–377 Author chain E； PDBConstruct 1–377； UniProt 1–377 Author chain F； PDBConstruct 1–377； UniProt 1–377

Tropomyosin alpha-1 chain

OrganismNot specified

UniProt P42639

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 16 Actin, alpha cardiac muscle 1 × 6 （B6VNT8） Troponin T2, cardiac type × 2 （I3LS66） ADENOSINE-5'-DIPHOSPHATE × 6 MAGNESIUM ION × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1c1g 1c1g

2 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
8dd0 8uww 8uwx 8uwy 8uyd 8uz5 8uz6 8uzx 8uzy 8v01 8v0i 8v0k

13 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TPM1_PIG
Isoform —
PDB entities 2
Chains and sequence ranges Author chain G； PDBConstruct 1–284； UniProt 1–284 Author chain H； PDBConstruct 1–284； UniProt 1–284 Author chain I； PDBConstruct 1–284； UniProt 1–284 Author chain J； PDBConstruct 1–284； UniProt 1–284 Author chain L； PDBConstruct 1–284； UniProt 1–284 Author chain M； PDBConstruct 1–284； UniProt 1–284 Author chain N； PDBConstruct 1–284； UniProt 1–284 Author chain O； PDBConstruct 1–284； UniProt 1–284

Troponin T2, cardiac type

OrganismNot specified

UniProt I3LS66

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 16 Actin, alpha cardiac muscle 1 × 6 （B6VNT8） Tropomyosin alpha-1 chain × 8 （P42639） ADENOSINE-5'-DIPHOSPHATE × 6 MAGNESIUM ION × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
8dd0

1 assemblies

View Construct and Data Evidence
UniProt name I3LS66_PIG
Isoform —
PDB entities 3
Chains and sequence ranges Author chain K； PDBConstruct 1–295； UniProt 1–295 Author chain P； PDBConstruct 1–295； UniProt 1–295

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8dd0
Deposition date deposition_date2022-06-17
Structure title titleThe structure of the native cardiac thin filament junction region
Keywords keywordsthin filament, actin, tropomyosin, troponin, MOTOR PROTEIN; MOTOR PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8dd0__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8dd0__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8dd0__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）56.04 Å
Rg (electron density)56.44 Å
Total Rg56.34 Å
Atom count22892
Residues2876
Excluded volume406820 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8dd0__assembly_1__model_1 hexadecameric （16） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 6 domains

CATH v4.4 (6 domains)

Domain ID domain_id8dd0A01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology640 — Actin; Chain A, domain 4
Homologous superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
Domain ID domain_id8dd0B01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology640 — Actin; Chain A, domain 4
Homologous superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
Domain ID domain_id8dd0C01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology640 — Actin; Chain A, domain 4
Homologous superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
Domain ID domain_id8dd0D01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology640 — Actin; Chain A, domain 4
Homologous superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
Domain ID domain_id8dd0E01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology640 — Actin; Chain A, domain 4
Homologous superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
Domain ID domain_id8dd0F01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology640 — Actin; Chain A, domain 4
Homologous superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
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7. Citations (1)