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9z9f

Structure of FabS1CE2_ER-2a in complex with the extracellular region of EGFR

Method: X-RAY DIFFRACTION D_max: 175.8 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9z9f
deposition_date	2025-11-18
last_revision	2026-06-03
title	Structure of FabS1CE2_ER-2a in complex with the extracellular region of EGFR
keywords	epidermal growth factor receptor, high-affinity antibody, dimerization arm, inhibition, SIGNALING PROTEIN; SIGNALING PROTEIN
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	53.21 Å
rg_electron	52.63 Å
i0	808108000.00
molecular_weight	225290.0 kDa
excluded_volume	277090 Å³
envelope_volume	446880 Å³
shell_volume	72871 Å³
envelope_diameter	177.7 Å
shell_rg	53.06 Å
envelope_rg	51.12 Å
shape_rg	52.55 Å
total_rg	52.91 Å
total_atoms	15753
n_residues	2101
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	175.8 Å
rg_real	53.14 Å
rg_real_error	1.61 Å
i0_real	8.0810e+08
i0_real_error	1.5640e+07
rg_reciprocal	53.26 Å
i0_reciprocal	808200000.0000
total_estimate	0.8742
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	70.3 Å
skewness	0.193
kurtosis	-0.417
angular_range	— – 0.1500 Å⁻¹
current_alpha	0.0000
highest_alpha	26240000.0000
n_real_points	31
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.885; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.993; Smooth: 0.712

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4. Crystallography & Experiment

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5. Entities & Polymer Info (10)

Entity 1 polymer

description	heavy chain
formula_weight	25513.5 kDa
mutation	K133Q and E164G
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	A,C
atom_count	15825

EVQLVESGGGLVQPGGSLRLSCAASGFTVYYAAMHWVRQAPGKGLEWVASISPYYGYTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARYYHFSWHWSSFGGSYYPGMDYWGQGTLVTVFNQIQGPSVFPLAPSSKSTSGGTAALGCLVKDYFPGPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 polymer

description	light chain
formula_weight	23198.7 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	B,D

DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVSWYVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGEC

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 3 polymer

description	Epidermal growth factor receptor
formula_weight	69133.8 kDa
ec_number	2.7.10.1
mutation	residue 25-645
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	G,K

LEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSLVPR

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 4 branched

description	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
formula_weight	424.4 kDa
src_method	man
entity_count	1

Entity 5 non-polymer

description	DI(HYDROXYETHYL)ETHER
formula_weight	106.1 kDa
src_method	syn
entity_count	2

Entity 6 non-polymer

description	SODIUM ION
formula_weight	23.0 kDa
src_method	syn
entity_count	9

Entity 7 non-polymer

description	CHLORIDE ION
formula_weight	35.5 kDa
src_method	syn
entity_count	3

Entity 8 non-polymer

description	1,2-ETHANEDIOL
formula_weight	62.1 kDa
src_method	syn
entity_count	2

Entity 9 non-polymer

description	2-acetamido-2-deoxy-beta-D-glucopyranose
formula_weight	221.2 kDa
src_method	syn
entity_count	7

Entity 10 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	10

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6. Citations (1)

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length_a	66.533 Å
length_b	113.846 Å
length_c	118.767 Å
angle_alpha	114.16 °
angle_beta	95.24 °
angle_gamma	104.88 °
z_pdb	2

space_group	P 1
int_tables_number	1
crystal_system	triclinic

resolution	3.060 Å
resolution_low	34.420 Å
r_factor	0.2144
r_work	0.2127
r_free	0.2487

fit	/app/data/saxs_computation/z9/9z9f/9z9f.fit
pddf	/app/data/pr_computation/z9/9z9f/9z9f.pr.out
profile	/app/data/saxs_computation/z9/9z9f/9z9f.dat

Structure of FabS1CE2_ER-2a in complex with the extracellular region of EGFR

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (10)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

Entity 4 branched

Entity 5 non-polymer

Entity 6 non-polymer

Entity 7 non-polymer

Entity 8 non-polymer

Entity 9 non-polymer

Entity 10 water

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)