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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P03070 New Search
45PDB entries
45Biological assembly
177chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1EJL MOUSE IMPORTIN ALPHA-SV40 LARGE T ANTIGEN NLS PEPTIDE COMPLEX Deposited 2000-03-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 126–132（7 aa） Fragment：NLS (NUCLEAR LOCALIZATION SIGNAL) MONOPARTITE PEPTIDE, RESIDUES 126-132
Chain B 126–132（7 aa） Fragment：NLS (NUCLEAR LOCALIZATION SIGNAL) MONOPARTITE PEPTIDE, RESIDUES 126-132
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；sodium citrate, Hepes, DTT, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.80 Å R-free 0.254
1GH6 RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN Deposited 2000-11-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 7–117（111 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.2
Resolution 3.20 Å R-free 0.314
1N25 Crystal structure of the SV40 Large T antigen helicase domain Deposited 2002-10-21 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 260–627（368 aa） Fragment：helicase domain
Chain B 260–627（368 aa） Fragment：helicase domain
Not recorded ZN ZINC ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.6；291 K；glycerol, DTT, Hepes, NaCl, EtOH, EDTA, pH 7.6, VAPOR DIFFUSION, HANGING DROP, temperature 291K
Resolution 2.80 Å R-free 0.276
1Q1S Mouse Importin alpha- phosphorylated SV40 CN peptide complex Deposited 2003-07-22 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 110–133（24 aa） Fragment：CN peptide - Ser112 chemically phosphorylated
Chain B 110–133（24 aa） Fragment：CN peptide - Ser112 chemically phosphorylated
Chain C 70–529（460 aa） Fragment：NLS binding domain (70-529)
Mutation：S120A, S123A, T124A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：S120A, S123A, T124A Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；Sodium Citrate, DTT, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.30 Å R-free 0.221
1Q1T Mouse Importin alpha: non-phosphorylated SV40 CN peptide complex Deposited 2003-07-22 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 110–133（24 aa） Fragment：CN peptide
Chain B 110–133（24 aa） Fragment：CN peptide
Chain C 70–529（460 aa） Fragment：NLS binding domain (70-529)
Mutation：S120A, S123A, T124A Mutation：S120A, S123A, T124A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.25；293 K；Sodium Citrate, DTT, pH 6.25, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.50 Å R-free 0.233
1SVL Co-crystal structure of SV40 large T antigen helicase domain and ADP Deposited 2004-03-29 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 251–627（377 aa） Fragment：HELICASE DOMAIN
Chain B 251–627（377 aa） Fragment：HELICASE DOMAIN
Chain C 251–627（377 aa） Fragment：HELICASE DOMAIN
Not recorded ZN ZINC ION × 6 MG MAGNESIUM ION × 6 ADP ADENOSINE-5'-DIPHOSPHATE × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.25；277 K；Tris, magnesium chloride, PEG 8000, DTT, pH 7.25, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 1.95 Å R-free 0.264
1SVM Co-crystal structure of SV40 large T antigen helicase domain and ATP Deposited 2004-03-29 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 251–627（377 aa） Fragment：HELICASE DOMAIN
Chain B 251–627（377 aa） Fragment：HELICASE DOMAIN
Chain C 251–627（377 aa） Fragment：HELICASE DOMAIN
Chain D 251–627（377 aa） Fragment：HELICASE DOMAIN
Chain E 251–627（377 aa） Fragment：HELICASE DOMAIN
Chain F 251–627（377 aa） Fragment：HELICASE DOMAIN
Not recorded ZN ZINC ION × 6 MG MAGNESIUM ION × 6 ATP ADENOSINE-5'-TRIPHOSPHATE × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.25；277 K；Tris, magnesium chloride, PEG 8000, DTT, pH 7.25, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 1.94 Å R-free 0.241
1SVO Structure of SV40 large T antigen helicase domain Deposited 2004-03-29 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 251–627（377 aa） Fragment：HELICASE DOMAIN
Chain B 251–627（377 aa） Fragment：HELICASE DOMAIN
Not recorded ZN ZINC ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.6；277 K；HEPES, NACL, ETHANOL, EDTA, DTT, pH 7.6, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.60 Å R-free 0.271
1TBD SOLUTION STRUCTURE OF THE ORIGIN DNA BINDING DOMAIN OF SV40 T-ANTIGEN, NMR, MINIMIZED AVERAGE STRUCTURE Deposited 1996-11-04 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 131–260（130 aa） Fragment：DNA BINDING DOMAIN
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5.5；303 K
Resolution not provided
1Z1D Structural Model for the interaction between RPA32 C-terminal domain and SV40 T antigen origin binding domain. Deposited 2005-03-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 131–259（129 aa） Fragment：SV40 T antigen Origin binding domain
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 0.03 M；Pressure ambient
NMR sample composition 0.2mM RPA32C U-15N, 0.6mM Tag-OBD, 20mM Tris buffer pH 7.0, 2 mM DTT, 5mM MgCl2, 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR sample composition 0.2mM Tag-OBD U-15N, 0.6mM RPA32C, 20mM Tris buffer pH 7.0, 2mM DTT, 5mM MgCl2, 90% H2O, 10% D2O | 90% H2O/10% D2O
Resolution not provided
2FUF Crystal structure of the SV40 large T antigen origin-binding domain Deposited 2006-01-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 131–260（130 aa） Fragment：DNA binding domain (residues 131-259)
Non-standard monomer：Yes (specific site not provided by mmCIF) FLC CITRATE ANION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.7；298 K；1.6 M Sodium citrate, pH 6.7, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.45 Å R-free 0.189
2IF9 Crystal Structure of SV40 T-antigen origin binding domain disulfide-linked dimer Deposited 2006-09-20 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 131–260（130 aa） Fragment：origin binding domain
Chain B 131–260（130 aa） Fragment：origin binding domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；293 K；30 % peg 4000, 0.1M sodium citrate (pH 5.6), 0.2 M ammonium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.59 Å R-free 0.296
2IPR Origin binding domain of the SV40 large T antigen (residues 131-259). P21 crystal form Deposited 2006-10-12 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 131–259（129 aa） Fragment：Origin binding domain (residues 131-259)
Chain B 131–259（129 aa） Fragment：Origin binding domain (residues 131-259)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.1；300 K；20 mM NaSCN, 10% P4K, 0.1 Tris, pH 8.1, VAPOR DIFFUSION, HANGING DROP, temperature 300K
Resolution 1.50 Å R-free 0.204
2ITJ Origin binding domain of the SV40 large T antigen (residues 131-259). P212121 crystal form Deposited 2006-10-19 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 131–259（129 aa） Fragment：Origin binding domain (residues 131-259)
Chain B 131–259（129 aa） Fragment：Origin binding domain (residues 131-259)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；297 K；20 mM NaAc, 20% PEG4K, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 297K
Resolution 2.50 Å R-free 0.289
2ITL The origin binding domain of the SV40 large T antigen bound to the functional pen palindrome DNA (23 bp) Deposited 2006-10-19 Assembly 1 Protein–DNA Homooligomer；Protein × 4 PDB declaration: octameric（8） Consistent with all polymers
Chain A 131–259（129 aa） Fragment：Origin binding domain (residues 131-259)
Chain B 131–259（129 aa） Fragment：Origin binding domain (residues 131-259)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；297 K；20 mM di-ammonium hydrogen citrate, 20% PEG 3000, and 10 mM MgCl2, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 297K
Resolution 1.65 Å R-free 0.251
2NL8 The origin binding domain of the SV40 large T antigen bound non specifically to a 17 bp palindrome DNA (sites 1 and 3) Deposited 2006-10-19 Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 131–259（129 aa） Fragment：Origin binding domain (residues 131-259)
Mutation：CYS216SER No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；297 K；20 mM NaAcetate, 20% PEG 3000 + 4% PEG 600, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 297K
Resolution 2.30 Å R-free 0.299
2NTC Crystal Structure of sv40 large T antigen origin binding domain with DNA Deposited 2006-11-07 Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 131–260（130 aa） Fragment：Origin binding domain (residues 131-259)
Chain B 131–260（130 aa） Fragment：Origin binding domain (residues 131-259)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6.5；273 K；0.1 M sodium cacodylate pH 6.5, 0.1 M calcium acetate, 30 % v/v peg 8000, 20 % glycerol, VAPOR DIFFUSION, temperature 273K
Resolution 2.40 Å R-free 0.287
2TBD SV40 T ANTIGEN DNA-BINDING DOMAIN, NMR, 30 STRUCTURES Deposited 1997-01-09 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 131–260（130 aa） Fragment：DNA BINDING DOMAIN, RESIDUES 131 - 260
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5.5；303 K
Resolution not provided
3QK2 Structure-Based Analysis of the Interaction between the Simian Virus 40 T-Antigen Origin Binding Domain and Single-Stranded DNA Deposited 2011-01-31 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 131–260（130 aa） Fragment：origin binding domain
Non-standard monomer：Yes (specific site not provided by mmCIF) SCN THIOCYANATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；278 K；0.2 M thiocyanate [SCN], 17.5% PEG 3350, 5% glycerol, VAPOR DIFFUSION, temperature 278K
Resolution 1.64 Å R-free 0.187
3QN2 Structure-based design of a disulfide-linked oligomeric form of the Simian Virus 40 (SV40) large T antigen DNA binding domain Deposited 2011-02-07 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 131–260（130 aa） Fragment：origin binding domain
Mutation：F151C, C216A, D256C FLC CITRATE ANION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；295 K；1.6 M sodium citrate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.66 Å R-free 0.191
4FGN Crystal structure of the SV40 large T-antigen origin bining domain bound to Site I DNA Deposited 2012-06-04 Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 131–260（130 aa） Fragment：origin binding domain, UNP residues 131-260
Chain B 131–260（130 aa） Fragment：origin binding domain, UNP residues 131-260
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；0.1M sodium acetate pH 4.6, .2M ammonium sulfate, 30 % Peg 4000, 10 mM CaCl2, VAPOR DIFFUSION, HANGING DROP, temperature 291K
Resolution 3.20 Å R-free 0.267
4RXH Crystal Structure of Importin-alpha from Neurospora crassa complexed with SV40NLS Deposited 2014-12-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 125–132（8 aa）
Chain C 125–132（8 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；297 K；20 Mm Bicine pH 8.5, 20%(w/v) PEG 6000, VAPOR DIFFUSION, SITTING DROP, temperature 297K
Resolution 1.76 Å R-free 0.211
5D9I SV40 Large T antigen origin binding domain bound to artificial DNA fork Deposited 2015-08-18 Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 131–260（130 aa） Fragment：unp residues 131-260
Chain B 131–260（130 aa） Fragment：unp residues 131-260
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) EDO 1,2-ETHANEDIOL × 2 CA CALCIUM ION × 2 ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；100 mM Tris, 300 mM NH4Cl, 28% polyethylene glycol [PEG] 4000, 20 mM CaCl2
Resolution 1.70 Å R-free 0.223
9EVH SV40 large T antigen assembly with DNA in presence of ADP Deposited 2024-03-29 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 1–708（708 aa）
Chain B 1–708（708 aa）
Chain C 1–708（708 aa）
Chain D 1–708（708 aa）
Chain E 1–708（708 aa）
Chain F 1–708（708 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；200 mM NaCl, 50 mM Tris-HCl (pH 8.0), 1 mM ADP.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.38 Å
9EVP SV40 LTAg assembly with DNA in presence of AMPPNP and Mg2+. Deposited 2024-04-01 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 6 MG MAGNESIUM ION × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM TrisHCl (pH 7.5), 1 mM DTT, 100 mM NaCl, 5 mM MgCl, 3 mM AMP-PMP.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.12 Å
9EXD SV40 LTAg assembly in presence of ATP. Deposited 2024-04-07 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–708（708 aa）
Chain B 1–708（708 aa）
Chain C 1–708（708 aa）
Chain D 1–708（708 aa）
Chain E 1–708（708 aa）
Chain F 1–708（708 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；200 mM NaCl, 50 mM Tris-HCl (pH 8.0), 1 mM ATP.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9F3T Active SV40 LTAg complex with DNA (3D variability component_000, frame_010). Deposited 2024-04-25 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM HEPES (pH 7.5), 1 mM ATP, 3 mM MgCl2, 1 mM DTT and 50 mM NaCl.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9F3U Active SV40 LTAg complex with DNA (3D variability component_001, frame_010). Deposited 2024-04-26 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM HEPES (pH 7.5), 1 mM ATP, 3 mM MgCl2, 1 mM DTT and 50 mM NaCl.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9F5I Active SV40 LTAg complex with DNA (3D variability component_000, frame_005). Deposited 2024-04-28 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM HEPES (pH 7.5), 1 mM ATP, 3 mM MgCl2, 1 mM DTT and 50 mM NaCl.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9F73 Active SV40 LTAg complex with DNA (3D variability component_002, frame_015). Deposited 2024-05-03 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM HEPES (pH 7.5), 1 mM ATP, 3 mM MgCl2, 1 mM DTT and 50 mM NaCl.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9F74 Active SV40 LTAg complex with DNA (3D variability component_000, frame_015). Deposited 2024-05-03 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM HEPES (pH 7.5), 1 mM ATP, 3 mM MgCl2, 1 mM DTT and 50 mM NaCl.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9F75 Active SV40 LTAg complex with DNA (3D variability component_000, frame_019). Deposited 2024-05-03 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM HEPES (pH 7.5), 1 mM ATP, 3 mM MgCl2, 1 mM DTT and 50 mM NaCl.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9F7N Active SV40 LTAg complex with DNA (3D variability component_000, frame_000). Deposited 2024-05-04 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM HEPES (pH 7.5), 1 mM ATP, 3 mM MgCl2, 1 mM DTT and 50 mM NaCl.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9F9N Active SV40 LTAg complex with DNA (3D variability component_001, frame_005). Deposited 2024-05-08 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM HEPES (pH 7.5), 1 mM ATP, 3 mM MgCl2, 1 mM DTT and 50 mM NaCl.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9F9O Active SV40 LTAg complex with DNA (3D variability component_001, frame_015). Deposited 2024-05-08 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM HEPES (pH 7.5), 1 mM ATP, 3 mM MgCl2, 1 mM DTT and 50 mM NaCl.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9F9W Active SV40 LTAg complex with DNA (3D variability component_001, frame_019). Deposited 2024-05-09 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 5 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM HEPES (pH 7.5), 1 mM ATP, 3 mM MgCl2, 1 mM DTT and 50 mM NaCl.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9F9X Active SV40 LTAg complex with DNA (3D variability component_001, frame_000). Deposited 2024-05-09 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM HEPES (pH 7.5), 1 mM ATP, 3 mM MgCl2, 1 mM DTT and 50 mM NaCl.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9FA1 Active SV40 LTAg complex with DNA (3D variability component_002, frame_010). Deposited 2024-05-09 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM HEPES (pH 7.5), 1 mM ATP, 3 mM MgCl2, 1 mM DTT and 50 mM NaCl.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9FA2 Active SV40 LTAg complex with DNA (3D variability component_002, frame_005). Deposited 2024-05-10 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM HEPES (pH 7.5), 1 mM ATP, 3 mM MgCl2, 1 mM DTT and 50 mM NaCl.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9FB0 Active SV40 LTAg complex with DNA (3D variability component_002, frame_019). Deposited 2024-05-10 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM HEPES (pH 7.5), 1 mM ATP, 3 mM MgCl2, 1 mM DTT and 50 mM NaCl.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9FB4 SV40 large T antigen assembly with DNA in presence of ATP. Deposited 2024-05-11 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: octameric（8） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；200 mM NaCl, 50 mM Tris-HCl (pH 8.0), 1 mM ATP.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.13 Å
9FB5 Active SV40 LTAg complex with DNA (3D variability component_002, frame_000). Deposited 2024-05-12 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: heptameric（7） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；50 mM HEPES (pH 7.5), 1 mM ATP, 3 mM MgCl2, 1 mM DTT and 50 mM NaCl.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9FB6 SV40 large T antigen assembly with DNA in presence of ATP. Deposited 2024-05-12 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: octameric（8） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；200 mM NaCl, 50 mM Tris-HCl (pH 8.0), 1 mM ATP.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.13 Å
9KAE CryoEM structure of LTag bound to SV40 EP half origin DNA Deposited 2024-10-28 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: octameric（8） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 6 MG MAGNESIUM ION × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9KAK CryoEM structure of LTag bound to SV40 AT half origin DNA Deposited 2024-10-29 Assembly 1 Protein–DNA Homooligomer；Protein × 6 PDB declaration: octameric（8） Consistent with all polymers
Chain A 266–627（362 aa）
Chain B 266–627（362 aa）
Chain C 266–627（362 aa）
Chain D 266–627（362 aa）
Chain E 266–627（362 aa）
Chain F 266–627（362 aa）
Not recorded ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 6 MG MAGNESIUM ION × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.