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1n25

Crystal structure of the SV40 Large T antigen helicase domain

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Large T Antigen

Simian virus 40

UniProt P03070

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 6 ZINC ION × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1tbd 2tbd 3qk2 3qn2

4 assemblies

Homodimer
2if9 2ipr 2itj

3 assemblies

Homotetramer

None

Other homooligomers
1n25 1q1s 1q1t 1svl 1svm 1svo 2fuf 9exd

8 assemblies

Heteromeric or nucleic-acid complex
1ejl 1gh6 1z1d 2itl 2nl8 2ntc 4fgn 4rxh 5d9i 9evh 9evp 9f3t

30 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TALA_SV40
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–368； UniProt 260–627 Author chain B； PDBConstruct 1–368； UniProt 260–627

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1n25
Deposition date deposition_date2002-10-21
Structure title titleCrystal structure of the SV40 Large T antigen helicase domain
Keywords keywordsHelicase domain, Viral protein; VIRAL PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1n25__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1n25__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1n25__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）42.36 Å
Rg (electron density)41.77 Å
Total Rg42.21 Å
Atom count17604
Residues2172
Excluded volume317890 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1n25__assembly_1__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 8 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd1n25a_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.20 — Extended AAA-ATPase domain
Domain ID domain_idd1n25b_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.20 — Extended AAA-ATPase domain

CATH v4.4 (6 domains)

Domain ID domain_id1n25A01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily510 — Zinc finger, large T-antigen D1 domain
Domain ID domain_id1n25A02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1050 — Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
Homologous superfamily homologous superfamily70 — Large T antigen, SV40, domain 3
Domain ID domain_id1n25A03
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id1n25B01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily510 — Zinc finger, large T-antigen D1 domain
Domain ID domain_id1n25B02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1050 — Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
Homologous superfamily homologous superfamily70 — Large T antigen, SV40, domain 3
Domain ID domain_id1n25B03
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
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7. Citations (1)