当前蛋白身份：P05230
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差异标签只比较当前检索结果；所有PDB和assembly原始记录仍分别保留。
相关结构差异明细
一行代表一个 PDB 条目中的一个 biological assembly；同一蛋白的多个单体会分别列出。
| PDB 条目 | Assembly / 聚集状态 | 构建体 | 突变与修饰 | 配体、离子与非聚合物 | 实验方法 | 实验环境 | 结构质量 |
|---|---|---|---|---|---|---|---|
| 1AXM HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR 提交 1997-10-16 | Assembly 1 其他组合 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
21–155（135 aa）
链 B
21–155（135 aa）
|
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 7；PROTEIN/HEPARIN COMPLEX WAS CRYSTALLIZED FROM 25% PEG 8000, 200 MM MGSO4, 100 MM HEPES, PH 7.0; CRYSTAL WAS SOAKED IN 22% XYLITOL PRIOR TO DATA COLLECTION.
|
分辨率 3.00 Å R-free 0.304 |
| 1AXM HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR 提交 1997-10-16 | Assembly 2 其他组合 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 D
21–155（135 aa）
链 F
21–155（135 aa）
|
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 7；PROTEIN/HEPARIN COMPLEX WAS CRYSTALLIZED FROM 25% PEG 8000, 200 MM MGSO4, 100 MM HEPES, PH 7.0; CRYSTAL WAS SOAKED IN 22% XYLITOL PRIOR TO DATA COLLECTION.
|
分辨率 3.00 Å R-free 0.304 |
| 1AXM HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR 提交 1997-10-16 | Assembly 3 其他组合 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 C
21–155（135 aa）
链 E
21–155（135 aa）
|
非标准单体：是（mmCIF未提供具体位点） 非标准单体：是（mmCIF未提供具体位点） | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 7；PROTEIN/HEPARIN COMPLEX WAS CRYSTALLIZED FROM 25% PEG 8000, 200 MM MGSO4, 100 MM HEPES, PH 7.0; CRYSTAL WAS SOAKED IN 22% XYLITOL PRIOR TO DATA COLLECTION.
|
分辨率 3.00 Å R-free 0.304 |
| 1DJS LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1 提交 1999-12-03 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 B
21–155（135 aa）
|
非标准单体：是（mmCIF未提供具体位点） | SO4 SULFATE ION × 18 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 7.5；1.6M AMMONIUM SULFATE, 10MM TRIS (PH7.5), pH 7.50
|
分辨率 2.40 Å R-free 0.315 |
| 1DJS LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1 提交 1999-12-03 | Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 8 PDB 声明：octameric（8） 与蛋白数一致 |
链 B
21–155（135 aa）
|
非标准单体：是（mmCIF未提供具体位点） | SO4 SULFATE ION × 36 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 7.5；1.6M AMMONIUM SULFATE, 10MM TRIS (PH7.5), pH 7.50
|
分辨率 2.40 Å R-free 0.315 |
| 1DZC High resolution structure of acidic fibroblast growth factor. Mutant FGF-4-ALA-(24-154), 24 NMR structures 提交 2000-02-24 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
25–155（131 aa）
片段：RESIDUES 25-155
|
突变：YES | 未记录非水小分子 | SOLUTION NMR |
NMR测量条件
pH 6；298 K；压力 1
NMR样品组成
WATER
|
分辨率未提供 |
| 1DZD High resolution structure of acidic fibroblast growth factor (27-154), 24 NMR structures 提交 2000-02-24 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
29–155（127 aa）
片段：RESIDUES 27-154
|
未记录 | 未记录非水小分子 | SOLUTION NMR |
NMR测量条件
pH 6；298 K；压力 1
NMR样品组成
WATER
|
分辨率未提供 |
| 1E0O CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX 提交 2000-04-03 | Assembly 1 其他组合 异源复合物；蛋白 × 4 PDB 声明：pentameric（5） 与全部聚合物一致 |
链 A
16–155（140 aa）
链 C
16–155（140 aa）
|
未记录 | NI NICKEL (II) ION × 5 SO4 SULFATE ION × 5 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 8.5；CRYSTALS WERE GROWN FROM: 1.0M LI2SO4, 0.1M TRISCL PH=8.5, 10MM NISO4, pH 8.50
|
分辨率 2.80 Å R-free 0.309 |
| 1EVT CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1) 提交 2000-04-20 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 A
22–155（134 aa）
片段：THE B-TREFOIL CORE OF FIBROBLAST GROWTH FACTOR 1 (FGF1)
链 B
22–155（134 aa）
片段：THE B-TREFOIL CORE OF FIBROBLAST GROWTH FACTOR 1 (FGF1)
|
未记录 | SO4 SULFATE ION × 4 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION；pH 7.5；298 K；PEG 4000, Isopropanol, HEPES-NaOH, pH 7.5, VAPOR DIFFUSION, temperature 298.0K
|
分辨率 2.80 Å R-free 0.300 |
| 1HKN A complex between acidic fibroblast growth factor and 5-amino-2-naphthalenesulfonate 提交 2003-03-10 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
17–155（139 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 7.8；CRYSTALS OF THE COMPLEX BETWEEN AFGF AND 5-AMINO-2-NMS WERE GROWN BY MIXING 0.75 MM PROTEIN, 1.5 MM OF THE INHIBITOR AND 60% SODIUM/PO, pH 7.80
|
分辨率 2.00 Å R-free 0.259 |
| 1HKN A complex between acidic fibroblast growth factor and 5-amino-2-naphthalenesulfonate 提交 2003-03-10 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
17–155（139 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 7.8；CRYSTALS OF THE COMPLEX BETWEEN AFGF AND 5-AMINO-2-NMS WERE GROWN BY MIXING 0.75 MM PROTEIN, 1.5 MM OF THE INHIBITOR AND 60% SODIUM/PO, pH 7.80
|
分辨率 2.00 Å R-free 0.259 |
| 1HKN A complex between acidic fibroblast growth factor and 5-amino-2-naphthalenesulfonate 提交 2003-03-10 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
17–155（139 aa）
|
未记录 | N2M 5-AMINO-NAPHTALENE-2-MONOSULFONATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 7.8；CRYSTALS OF THE COMPLEX BETWEEN AFGF AND 5-AMINO-2-NMS WERE GROWN BY MIXING 0.75 MM PROTEIN, 1.5 MM OF THE INHIBITOR AND 60% SODIUM/PO, pH 7.80
|
分辨率 2.00 Å R-free 0.259 |
| 1HKN A complex between acidic fibroblast growth factor and 5-amino-2-naphthalenesulfonate 提交 2003-03-10 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
17–155（139 aa）
|
未记录 | N2M 5-AMINO-NAPHTALENE-2-MONOSULFONATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 7.8；CRYSTALS OF THE COMPLEX BETWEEN AFGF AND 5-AMINO-2-NMS WERE GROWN BY MIXING 0.75 MM PROTEIN, 1.5 MM OF THE INHIBITOR AND 60% SODIUM/PO, pH 7.80
|
分辨率 2.00 Å R-free 0.259 |
| 1HKN A complex between acidic fibroblast growth factor and 5-amino-2-naphthalenesulfonate 提交 2003-03-10 | Assembly 5 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 E
17–155（139 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 7.8；CRYSTALS OF THE COMPLEX BETWEEN AFGF AND 5-AMINO-2-NMS WERE GROWN BY MIXING 0.75 MM PROTEIN, 1.5 MM OF THE INHIBITOR AND 60% SODIUM/PO, pH 7.80
|
分辨率 2.00 Å R-free 0.259 |
| 1HKN A complex between acidic fibroblast growth factor and 5-amino-2-naphthalenesulfonate 提交 2003-03-10 | Assembly 6 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 F
17–155（139 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 7.8；CRYSTALS OF THE COMPLEX BETWEEN AFGF AND 5-AMINO-2-NMS WERE GROWN BY MIXING 0.75 MM PROTEIN, 1.5 MM OF THE INHIBITOR AND 60% SODIUM/PO, pH 7.80
|
分辨率 2.00 Å R-free 0.259 |
| 1JQZ Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag. 提交 2001-08-09 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
未记录 | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 5.8；283 K；sodium formate, ammonium sulfate, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 283K
|
分辨率 1.65 Å |
| 1JQZ Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag. 提交 2001-08-09 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
未记录 | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 5.8；283 K；sodium formate, ammonium sulfate, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 283K
|
分辨率 1.65 Å |
| 1JT3 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Histidine Tag AND LEU 73 REPLACED BY VAL (L73V) 提交 2001-08-20 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L73V | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；283 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 283K
|
分辨率 1.95 Å |
| 1JT3 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Histidine Tag AND LEU 73 REPLACED BY VAL (L73V) 提交 2001-08-20 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：L73V | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；283 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 283K
|
分辨率 1.95 Å |
| 1JT3 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Histidine Tag AND LEU 73 REPLACED BY VAL (L73V) 提交 2001-08-20 | Assembly 3 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
16–155（140 aa）
链 B
16–155（140 aa）
|
突变：L73V 突变：L73V | SO4 SULFATE ION × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；283 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 283K
|
分辨率 1.95 Å |
| 1JT3 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Histidine Tag AND LEU 73 REPLACED BY VAL (L73V) 提交 2001-08-20 | Assembly 4 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
16–155（140 aa）
链 B
16–155（140 aa）
|
突变：L73V 突变：L73V | SO4 SULFATE ION × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；283 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 283K
|
分辨率 1.95 Å |
| 1JT4 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND VAL 109 REPLACED BY LEU (V109L) 提交 2001-08-20 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：V109L | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.78 Å |
| 1JT4 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND VAL 109 REPLACED BY LEU (V109L) 提交 2001-08-20 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：V109L | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.78 Å |
| 1JT5 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L73V/V109L) 提交 2001-08-20 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L73V,V109L | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；283 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 283K
|
分辨率 1.85 Å |
| 1JT5 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L73V/V109L) 提交 2001-08-20 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：L73V,V109L | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；283 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 283K
|
分辨率 1.85 Å |
| 1JT5 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L73V/V109L) 提交 2001-08-20 | Assembly 3 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
16–155（140 aa）
链 B
16–155（140 aa）
|
突变：L73V,V109L 突变：L73V,V109L | SO4 SULFATE ION × 4 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；283 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 283K
|
分辨率 1.85 Å |
| 1JT5 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L73V/V109L) 提交 2001-08-20 | Assembly 4 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
16–155（140 aa）
链 B
16–155（140 aa）
|
突变：L73V,V109L 突变：L73V,V109L | SO4 SULFATE ION × 4 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；283 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 283K
|
分辨率 1.85 Å |
| 1JT7 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L44F/L73V/V109L) 提交 2001-08-20 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L44F,L73V,V109L | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；283 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 283K
|
分辨率 1.70 Å |
| 1JT7 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L44F/L73V/V109L) 提交 2001-08-20 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：L44F,L73V,V109L | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；283 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 283K
|
分辨率 1.70 Å |
| 1JT7 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L44F/L73V/V109L) 提交 2001-08-20 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
16–155（140 aa）
|
突变：L44F,L73V,V109L | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；283 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 283K
|
分辨率 1.70 Å |
| 1JT7 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L44F/L73V/V109L) 提交 2001-08-20 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
16–155（140 aa）
|
突变：L44F,L73V,V109L | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；283 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 283K
|
分辨率 1.70 Å |
| 1JTC Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE (L44F) 提交 2001-08-20 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L44F | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.70 Å |
| 1JTC Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE (L44F) 提交 2001-08-20 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：L44F | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.70 Å |
| 1JTC Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE (L44F) 提交 2001-08-20 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
16–155（140 aa）
|
突变：L44F | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.70 Å |
| 1JTC Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE (L44F) 提交 2001-08-20 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
16–155（140 aa）
|
突变：L44F | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.70 Å |
| 1JY0 Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag and Cys 117 replaced with Val (C117V). 提交 2001-09-10 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：C117V | FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.70 Å |
| 1JY0 Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag and Cys 117 replaced with Val (C117V). 提交 2001-09-10 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：C117V | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.70 Å |
| 1K5U Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag with His93 replaced by Gly (H93G). 提交 2001-10-12 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–154（139 aa）
|
突变：H93G | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；PEG 4,000, 2-propanol, magnesium chloride, hepes., pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.00 Å R-free 0.293 |
| 1K5U Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag with His93 replaced by Gly (H93G). 提交 2001-10-12 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–154（139 aa）
|
突变：H93G | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；PEG 4,000, 2-propanol, magnesium chloride, hepes., pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.00 Å R-free 0.293 |
| 1K5U Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag with His93 replaced by Gly (H93G). 提交 2001-10-12 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
16–154（139 aa）
|
突变：H93G | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；PEG 4,000, 2-propanol, magnesium chloride, hepes., pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.00 Å R-free 0.293 |
| 1K5V Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag with Asn106 replaced by Gly (N106G). 提交 2001-10-12 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–154（139 aa）
|
突变：N106G | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6；298.15 K；PEG20,000, MES, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.10 Å R-free 0.308 |
| 1K5V Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag with Asn106 replaced by Gly (N106G). 提交 2001-10-12 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–154（139 aa）
|
突变：N106G | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6；298.15 K；PEG20,000, MES, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.10 Å R-free 0.308 |
| 1M16 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag and Leu 44 Replaced with Phe (L44F), Leu 73 Replaced with Val (L73V), Val 109 Replaced with Leu (V109L) and Cys 117 Replaced with Val (C117V). 提交 2002-06-17 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L44F, L73V, V109L, C117V | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.70 Å R-free 0.249 |
| 1M16 Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag and Leu 44 Replaced with Phe (L44F), Leu 73 Replaced with Val (L73V), Val 109 Replaced with Leu (V109L) and Cys 117 Replaced with Val (C117V). 提交 2002-06-17 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：L44F, L73V, V109L, C117V | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.70 Å R-free 0.249 |
| 1NZK Crystal Structure of a Multiple Mutant (L44F, L73V, V109L, L111I, C117V) of Human Acidic Fibroblast Growth Factor 提交 2003-02-18 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–152（137 aa）
|
突变：L44F, L73V, V109L, L111I, C117V | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Sodium Formate, Ammonium Sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.95 Å R-free 0.253 |
| 1NZK Crystal Structure of a Multiple Mutant (L44F, L73V, V109L, L111I, C117V) of Human Acidic Fibroblast Growth Factor 提交 2003-02-18 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–152（137 aa）
|
突变：L44F, L73V, V109L, L111I, C117V | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Sodium Formate, Ammonium Sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.95 Å R-free 0.253 |
| 1NZK Crystal Structure of a Multiple Mutant (L44F, L73V, V109L, L111I, C117V) of Human Acidic Fibroblast Growth Factor 提交 2003-02-18 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
16–152（137 aa）
|
突变：L44F, L73V, V109L, L111I, C117V | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Sodium Formate, Ammonium Sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.95 Å R-free 0.253 |
| 1NZK Crystal Structure of a Multiple Mutant (L44F, L73V, V109L, L111I, C117V) of Human Acidic Fibroblast Growth Factor 提交 2003-02-18 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
16–152（137 aa）
|
突变：L44F, L73V, V109L, L111I, C117V | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Sodium Formate, Ammonium Sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.95 Å R-free 0.253 |
| 1P63 Human Acidic Fibroblast Growth Factor. 140 Amino Acid Form with Amino Terminal His Tag and Leu111 Replaced with Ile (L111I) 提交 2003-04-28 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
片段：140 Amino Acid Form with Amino Terminal His Tag
|
突变：L111I | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；Sodium Formate, Ammonium Sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.60 Å R-free 0.251 |
| 1P63 Human Acidic Fibroblast Growth Factor. 140 Amino Acid Form with Amino Terminal His Tag and Leu111 Replaced with Ile (L111I) 提交 2003-04-28 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
片段：140 Amino Acid Form with Amino Terminal His Tag
|
突变：L111I | FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；Sodium Formate, Ammonium Sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.60 Å R-free 0.251 |
| 1PZZ Crystal structure of FGF-1, V51N mutant 提交 2003-07-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：V51N | SO4 SULFATE ION × 2 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.00 Å R-free 0.227 |
| 1PZZ Crystal structure of FGF-1, V51N mutant 提交 2003-07-14 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：V51N | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.00 Å R-free 0.227 |
| 1Q03 Crystal structure of FGF-1, S50G/V51G mutant 提交 2003-07-15 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：S50G, V51G | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.05 Å R-free 0.227 |
| 1Q03 Crystal structure of FGF-1, S50G/V51G mutant 提交 2003-07-15 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：S50G, V51G | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.05 Å R-free 0.227 |
| 1Q04 Crystal structure of FGF-1, S50E/V51N 提交 2003-07-15 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：S50E/V51N | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.80 Å R-free 0.214 |
| 1Q04 Crystal structure of FGF-1, S50E/V51N 提交 2003-07-15 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：S50E/V51N | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.80 Å R-free 0.214 |
| 1QQL THE CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 7/1 CHIMERA 提交 1999-06-07 | Assembly 1 信息不足 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
92–155（64 aa）
片段：;DUAL-FUNCTION CHIMERA BETWEEN RAT FGF-7 ENCODED BY EXON 1 AND 2 AND HUMAN FGF-1 ENCODED BY EXON 3,DUAL-FUNCTION CHIMERA BETWEEN RAT FGF-7 ENCODED BY EXON 1 AND 2 AND HUMAN FGF-1 ENCODED BY EXON 3
;
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；SODIUM PHOSPHATE, POTASSIUM PHOSPHATE, SODIUM SULPHATE, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
分辨率 2.30 Å R-free 0.328 |
| 1RG8 Human Acidic Fibroblast Growth Factor (haFGF-1) at 1.10 angstrom resolution (140 amino acid form) 提交 2003-11-11 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
未记录 | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 5.8；298 K；sodium phosphate, sodium chloride, ammonium sulfate, DTT, EDTA, sodium formate, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.10 Å R-free 0.171 |
| 1RG8 Human Acidic Fibroblast Growth Factor (haFGF-1) at 1.10 angstrom resolution (140 amino acid form) 提交 2003-11-11 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
未记录 | FMT FORMIC ACID × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 5.8；298 K；sodium phosphate, sodium chloride, ammonium sulfate, DTT, EDTA, sodium formate, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.10 Å R-free 0.171 |
| 1RML NMR STUDY OF ACID FIBROBLAST GROWTH FACTOR BOUND TO 1,3,6-NAPHTHALENE TRISULPHONATE, 26 STRUCTURES 提交 1998-05-21 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–155（155 aa）
片段：RESIDUES 23 - 154
|
未记录 | NTS NAPHTHALENE TRISULFONATE × 1 | SOLUTION NMR |
NMR测量条件
pH 6；298 K
NMR样品组成
WATER
|
分辨率未提供 |
| 1RY7 Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1 提交 2003-12-19 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–155（155 aa）
片段：FGF1
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；Peg 4000, glycerol, MPD, cadmium chloride, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
分辨率 3.20 Å R-free 0.341 |
| 1YTO Crystal Structure of Gly19 deletion Mutant of Human Acidic Fibroblast Growth Factor 提交 2005-02-10 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
未记录 | SO4 SULFATE ION × 2 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.10 Å R-free 0.250 |
| 1YTO Crystal Structure of Gly19 deletion Mutant of Human Acidic Fibroblast Growth Factor 提交 2005-02-10 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.10 Å R-free 0.250 |
| 1YTO Crystal Structure of Gly19 deletion Mutant of Human Acidic Fibroblast Growth Factor 提交 2005-02-10 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
16–155（140 aa）
|
未记录 | FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.10 Å R-free 0.250 |
| 1YTO Crystal Structure of Gly19 deletion Mutant of Human Acidic Fibroblast Growth Factor 提交 2005-02-10 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
16–155（140 aa）
|
未记录 | SO4 SULFATE ION × 2 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；sodium formate, ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.10 Å R-free 0.250 |
| 1Z2V Crystal Structure of Glu60 deletion Mutant of Human Acidic Fibroblast Growth Factor 提交 2005-03-09 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
未记录 | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；PEG400, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.90 Å R-free 0.221 |
| 1Z2V Crystal Structure of Glu60 deletion Mutant of Human Acidic Fibroblast Growth Factor 提交 2005-03-09 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
未记录 | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；PEG400, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.90 Å R-free 0.221 |
| 1Z4S Crystal Structure of Gly19 and Glu60 deletion mutant of Human Acidic Fibroblast Growth Factor 提交 2005-03-16 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.60 Å R-free 0.235 |
| 1Z4S Crystal Structure of Gly19 and Glu60 deletion mutant of Human Acidic Fibroblast Growth Factor 提交 2005-03-16 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
未记录 | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.60 Å R-free 0.235 |
| 1Z4S Crystal Structure of Gly19 and Glu60 deletion mutant of Human Acidic Fibroblast Growth Factor 提交 2005-03-16 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
16–155（140 aa）
|
未记录 | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.60 Å R-free 0.235 |
| 1Z4S Crystal Structure of Gly19 and Glu60 deletion mutant of Human Acidic Fibroblast Growth Factor 提交 2005-03-16 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
16–155（140 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.60 Å R-free 0.235 |
| 2AFG 2.0 ANGSTROM X-RAY STRUCTURE OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR 提交 1995-07-21 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
未记录 | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.00 Å |
| 2AFG 2.0 ANGSTROM X-RAY STRUCTURE OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR 提交 1995-07-21 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
未记录 | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.00 Å |
| 2AFG 2.0 ANGSTROM X-RAY STRUCTURE OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR 提交 1995-07-21 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
16–155（140 aa）
|
未记录 | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.00 Å |
| 2AFG 2.0 ANGSTROM X-RAY STRUCTURE OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR 提交 1995-07-21 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
16–155（140 aa）
|
未记录 | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.00 Å |
| 2AQZ Crystal structure of FGF-1, S17T/N18T/G19 deletion mutant 提交 2005-08-18 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.85 Å R-free 0.226 |
| 2AQZ Crystal structure of FGF-1, S17T/N18T/G19 deletion mutant 提交 2005-08-18 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
未记录 | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.85 Å R-free 0.226 |
| 2AXM HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR 提交 1997-10-20 | Assembly 1 其他组合 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
21–155（135 aa）
链 B
21–155（135 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 7；PROTEIN/HEPARIN COMPLEX WAS CRYSTALLIZED FROM 25% PEG 8000, 200 MM MGSO4, 100 MM HEPES, PH 7.0; CRYSTAL WAS SOAKED IN 22% XYLITOL PRIOR TO DATA COLLECTION.
|
分辨率 3.00 Å R-free 0.307 |
| 2ERM Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue 提交 2005-10-25 | Assembly 1 其他组合 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
17–155（139 aa）
|
未记录 | IPA ISOPROPYL ALCOHOL × 1 | SOLUTION NMR |
NMR测量条件
pH 6；298 K；离子强度（mmCIF原始值）150 mM NaCl；压力 ambient
NMR样品组成
1 mM FGF-1 U-15N; 1 mM heparin-like hexasaccharide; 10mM sodium phosphate; 150 mM sodium chloride; 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR样品组成
1 mM FGF-1 U-15N,13C; 1 mM heparin-like hexasaccharide; 10mM sodium phosphate; 150 mM sodium chloride; 90% H2O, 10% D2O | 90% H2O/10% D2O
|
分辨率未提供 |
| 2HW9 Crystal structure of Lys12Cys/Cys117Val mutant of human acidic fibroblast Growth factor at 1.60 angstrom resolution. 提交 2006-08-01 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：K12C,C117V | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Ammonium Sulfate, Sodium Formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.60 Å R-free 0.221 |
| 2HW9 Crystal structure of Lys12Cys/Cys117Val mutant of human acidic fibroblast Growth factor at 1.60 angstrom resolution. 提交 2006-08-01 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：K12C,C117V | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Ammonium Sulfate, Sodium Formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.60 Å R-free 0.221 |
| 2HWA Crystal structure of Lys12Thr/Cys117Val mutant of human acidic fibroblast growth factor at 1.65 angstrom resolution. 提交 2006-08-01 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：K12T,C117V | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Ammonium Sulfate, Sodium Formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.65 Å R-free 0.258 |
| 2HWA Crystal structure of Lys12Thr/Cys117Val mutant of human acidic fibroblast growth factor at 1.65 angstrom resolution. 提交 2006-08-01 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：K12T,C117V | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Ammonium Sulfate, Sodium Formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.65 Å R-free 0.258 |
| 2HWM Crystal structure of Lys12Val/Cys117Val mutant of human acidic fibroblast growth factor at 1.60 angstrom resolution 提交 2006-08-01 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：K12V, C117V | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Ammonium Sulfate, Sodium Formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.60 Å R-free 0.225 |
| 2HWM Crystal structure of Lys12Val/Cys117Val mutant of human acidic fibroblast growth factor at 1.60 angstrom resolution 提交 2006-08-01 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：K12V, C117V | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Ammonium Sulfate, Sodium Formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.60 Å R-free 0.225 |
| 2HZ9 Crystal structure of Lys12Val/Asn95Val/Cys117Val mutant of human acidic fibroblast growth factor at 1.70 angstrom resolution. 提交 2006-08-08 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：Lys12Val, Asn95Val, Cys117Val | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Ammonium Sulfate, Sodium Formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.70 Å R-free 0.226 |
| 2HZ9 Crystal structure of Lys12Val/Asn95Val/Cys117Val mutant of human acidic fibroblast growth factor at 1.70 angstrom resolution. 提交 2006-08-08 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：Lys12Val, Asn95Val, Cys117Val | FMT FORMIC ACID × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；Ammonium Sulfate, Sodium Formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.70 Å R-free 0.226 |
| 2K43 Acidic fibroblast growth factor solution structure in the FGF-1-C2A binary complex: key component in the fibroblast growthfactor non-classical pathway 提交 2008-05-28 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
23–155（133 aa）
片段：UNP residues 23-155
|
未记录 | 未记录非水小分子 | SOLUTION NMR |
NMR测量条件
pH 6；298 K；离子强度（mmCIF原始值）50mM (NH4)2SO4；压力 ambient
NMR样品组成
1.0mM FGF-1, 90% H2O, 10% D2O | 90% H2O/10% D2O
|
分辨率未提供 |
| 2K4A FGF-1-C2A binary complex structure: a key component in the fibroblast growthfactor non-classical pathway 提交 2008-06-02 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
23–155（133 aa）
片段：UNP residues 23-155
|
未记录 | 未记录非水小分子 | SOLUTION NMR |
NMR测量条件
pH 6；298 K；离子强度（mmCIF原始值）50mM (NH4)2SO4；压力 ambient
NMR样品组成
1.2mM FGF-1-C2A; 100% D2O | 100% D2O
|
分辨率未提供 |
| 2K8R Solution structure of human acidic fibroblast growth factor in complex with anti-angiogenic drug inositol hexaphosphate (IP6) 提交 2008-09-22 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
23–155（133 aa）
片段：UNP residues 23-155
|
未记录 | IHP INOSITOL HEXAKISPHOSPHATE × 1 | SOLUTION NMR |
NMR测量条件
pH 6.8；298 K；离子强度（mmCIF原始值）0.1；压力 ambient
NMR样品组成
1.5 mM [U-100% 13C; U-100% 15N] protein, 1.5 mM INOSITOL HEXAKISPHOSPHATE, 100 mM ammonium sulfate, 25 mM sodium phosphate, 90% H2O/10% D2O | 90% H2O/10% D2O
|
分辨率未提供 |
| 2KI4 FGF1-S100A13 complex structure: key component in non-classical path way of FGF1 提交 2009-04-27 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 A
23–155（133 aa）
链 D
23–155（133 aa）
|
未记录 | 未记录非水小分子 | SOLUTION NMR |
NMR测量条件
pH 6；298 K；离子强度（mmCIF原始值）0.1；压力 ambient
NMR样品组成
1.2 mM [U-100% 13C; U-100% 15N] entity_1-1, 1.2 mM [U-100% 13C; U-100% 15N] entity_2-2, entity_3-3, 90% H2O/10% D2O | 90% H2O/10% D2O
|
分辨率未提供 |
| 2KI6 The FGF1-S100A13-C2A hetero-hexameric complex structure: A component in the non-classical pathway for FGF1 secretion 提交 2009-04-28 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 6 PDB 声明：hexameric（6） 与蛋白数一致 |
链 B
23–155（133 aa）
链 E
23–155（133 aa）
|
未记录 | 未记录非水小分子 | SOLUTION NMR |
NMR测量条件
pH 6；298 K；离子强度（mmCIF原始值）0.1；压力 ambient
NMR样品组成
1.0mM [U-100% 13C; U-100% 15N] C2A domain of Syt1-1, 1.0mM FGF1-2, 1.0mM S100A13-3, S100A13-4, 25mM sodium phosphate-5, 100mM sodium chloride-6, 90% H2O/10% D2O | 90% H2O/10% D2O
|
分辨率未提供 |
| 2NTD Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations 提交 2006-11-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：C117V, P134C | FMT FORMIC ACID × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.6M sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.52 Å R-free 0.229 |
| 2NTD Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations 提交 2006-11-07 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：C117V, P134C | FMT FORMIC ACID × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.6M sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.52 Å R-free 0.229 |
| 2NTD Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations 提交 2006-11-07 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
16–155（140 aa）
|
突变：C117V, P134C | FMT FORMIC ACID × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.6M sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.52 Å R-free 0.229 |
| 2NTD Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations 提交 2006-11-07 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
16–155（140 aa）
|
突变：C117V, P134C | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.6M sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.52 Å R-free 0.229 |
| 2Q9X Crystal structure of highly stable mutant Q40P/S47I/H93G of human fibroblast growth factor-1 提交 2007-06-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：Q40P, S47I, H93G | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；15% PEG 8000, 100mM TrisHCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
分辨率 1.70 Å R-free 0.245 |
| 2RQ9 Solution structure of human acidic fibroblast growth factor (aFGF) in the presence of a protein stabilizer NDSB-new 提交 2009-03-12 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–155（134 aa）
片段：residues in UNP, 22-155
|
未记录 | 未记录非水小分子 | SOLUTION NMR |
NMR测量条件
pH 6.6；298 K；离子强度（mmCIF原始值）190；压力 ambient
NMR样品组成
1.0mM [U-99% 13C; U-99% 15N] aFGF-1, 500mM NDSB-new-2, 25mM sodium phosphate-3, 150mM NaCl-4, 1mM dioxane-5, 90% H2O/10% D2O | 90% H2O/10% D2O
|
分辨率未提供 |
| 3B9U Crystal structure of L26N/D28N/H93G mutant of Human acidic fibroblast growth factor 提交 2007-11-06 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L26N, D28N, H93G | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；PEG4000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.55 Å R-free 0.200 |
| 3BA4 Crystal structure of L26D mutant of Human acidic fibroblast growth factor 提交 2007-11-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L26D | SO4 SULFATE ION × 2 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；2.9M Na-formate, 0.7M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.80 Å R-free 0.219 |
| 3BA4 Crystal structure of L26D mutant of Human acidic fibroblast growth factor 提交 2007-11-07 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：L26D | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；2.9M Na-formate, 0.7M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.80 Å R-free 0.219 |
| 3BA5 Crystal structure of D28A mutant of Human acidic fibroblast growth factor 提交 2007-11-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：D28A | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；4.6M Na-formate, 0.3M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.75 Å R-free 0.232 |
| 3BA5 Crystal structure of D28A mutant of Human acidic fibroblast growth factor 提交 2007-11-07 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：D28A | FMT FORMIC ACID × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；4.6M Na-formate, 0.3M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.75 Å R-free 0.232 |
| 3BA7 Crystal structure of L26N/D28A mutant of Human acidic fibroblast growth factor 提交 2007-11-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L26N, D28A | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；3.0M Na-formate, 0.5M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.60 Å R-free 0.225 |
| 3BA7 Crystal structure of L26N/D28A mutant of Human acidic fibroblast growth factor 提交 2007-11-07 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：L26N, D28A | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；3.0M Na-formate, 0.5M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.60 Å R-free 0.225 |
| 3BAD Crystal structure of D70A/H93G mutant of Human acidic fibroblast growth factor 提交 2007-11-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：D70A, H93G | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 9.5；298.15 K；25% PEG4000, 0.1M Bicine, pH 9.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.00 Å R-free 0.253 |
| 3BAD Crystal structure of D70A/H93G mutant of Human acidic fibroblast growth factor 提交 2007-11-07 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：D70A, H93G | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 9.5；298.15 K；25% PEG4000, 0.1M Bicine, pH 9.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 2.00 Å R-free 0.253 |
| 3BAG Crystal structure of K112N/N114A mutant of Human acidic fibroblast growth factor 提交 2007-11-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：K112N, N114A | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；3.8M Na-formate, 0.2M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.75 Å R-free 0.224 |
| 3BAG Crystal structure of K112N/N114A mutant of Human acidic fibroblast growth factor 提交 2007-11-07 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：K112N, N114A | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；3.8M Na-formate, 0.2M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.75 Å R-free 0.224 |
| 3BAH Crystal structure of K112N mutant of Human acidic fibroblast growth factor 提交 2007-11-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：K112N | FMT FORMIC ACID × 6 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；2.9M Na-formate, 1.0M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.65 Å R-free 0.205 |
| 3BAH Crystal structure of K112N mutant of Human acidic fibroblast growth factor 提交 2007-11-07 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：K112N | FMT FORMIC ACID × 4 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；2.9M Na-formate, 1.0M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.65 Å R-free 0.205 |
| 3BAO Crystal structure of L26N mutant of Human acidic fibroblast growth factor 提交 2007-11-08 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L26N | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；3.3M Na-formate, 0.7M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.55 Å R-free 0.211 |
| 3BAO Crystal structure of L26N mutant of Human acidic fibroblast growth factor 提交 2007-11-08 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：L26N | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；3.3M Na-formate, 0.7M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.55 Å R-free 0.211 |
| 3BAQ Crystal structure of L26A mutant of Human acidic fibroblast growth factor 提交 2007-11-08 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L26A | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；3.3M Na-formate, 0.4M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.80 Å R-free 0.216 |
| 3BAQ Crystal structure of L26A mutant of Human acidic fibroblast growth factor 提交 2007-11-08 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：L26A | FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；3.3M Na-formate, 0.4M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.80 Å R-free 0.216 |
| 3BAU Crystal structure of K12V/L26D/D28A mutant of Human acidic fibroblast growth factor 提交 2007-11-08 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：K12V, L26D, D28A | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；2.7M Na-formate, 0.7M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.60 Å R-free 0.233 |
| 3BAU Crystal structure of K12V/L26D/D28A mutant of Human acidic fibroblast growth factor 提交 2007-11-08 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：K12V, L26D, D28A | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；2.7M Na-formate, 0.7M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.60 Å R-free 0.233 |
| 3BAV Crystal structure of L26A/D28N mutant of Human acidic fibroblast growth factor 提交 2007-11-08 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L26A, D28N | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；3.3M Na-formate, 0.4M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.62 Å R-free 0.218 |
| 3BAV Crystal structure of L26A/D28N mutant of Human acidic fibroblast growth factor 提交 2007-11-08 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：L26A, D28N | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；3.3M Na-formate, 0.4M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.62 Å R-free 0.218 |
| 3BB2 Crystal structure of L26D/D28N mutant of Human acidic fibroblast growth factor 提交 2007-11-09 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L26D, D28N | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；2.8M Na-formate, 0.6M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.50 Å R-free 0.228 |
| 3BB2 Crystal structure of L26D/D28N mutant of Human acidic fibroblast growth factor 提交 2007-11-09 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：L26D, D28N | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；2.8M Na-formate, 0.6M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
|
分辨率 1.50 Å R-free 0.228 |
| 3CQA Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala and Lys101Ala 提交 2008-04-02 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
片段：UNP residues 16-152
|
突变：E81A and K101A | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.3 M sodium formate and 0.4 M ammonium sulphate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.80 Å R-free 0.212 |
| 3CQA Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala and Lys101Ala 提交 2008-04-02 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
片段：UNP residues 16-152
|
突变：E81A and K101A | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.3 M sodium formate and 0.4 M ammonium sulphate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.80 Å R-free 0.212 |
| 3CQA Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala and Lys101Ala 提交 2008-04-02 | Assembly 3 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
16–155（140 aa）
片段：UNP residues 16-152
链 B
16–155（140 aa）
片段：UNP residues 16-152
|
突变：E81A and K101A 突变：E81A and K101A | SO4 SULFATE ION × 2 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.3 M sodium formate and 0.4 M ammonium sulphate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.80 Å R-free 0.212 |
| 3CRG Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala, Glu82Asn and Lys101Ala 提交 2008-04-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：E81A, E82N and K101A | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.1 M sodium formate and 0.4 M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.85 Å R-free 0.221 |
| 3CRG Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala, Glu82Asn and Lys101Ala 提交 2008-04-07 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：E81A, E82N and K101A | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.1 M sodium formate and 0.4 M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.85 Å R-free 0.221 |
| 3CRH Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser and Lys101Ala 提交 2008-04-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：E81S and K101A | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；1.5 M sodium formate and 0.4 M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.15 Å R-free 0.227 |
| 3CRH Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser and Lys101Ala 提交 2008-04-07 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：E81S and K101A | SO4 SULFATE ION × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；1.5 M sodium formate and 0.4 M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.15 Å R-free 0.227 |
| 3CRH Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser and Lys101Ala 提交 2008-04-07 | Assembly 3 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
16–155（140 aa）
链 B
16–155（140 aa）
|
突变：E81S and K101A 突变：E81S and K101A | SO4 SULFATE ION × 5 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；1.5 M sodium formate and 0.4 M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.15 Å R-free 0.227 |
| 3CRI Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser, Glu82Asn and Lys101Ala 提交 2008-04-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：E81S, E82N and K101A | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.3 M sodium formate and 0.4 M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.10 Å R-free 0.228 |
| 3CRI Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser, Glu82Asn and Lys101Ala 提交 2008-04-07 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：E81S, E82N and K101A | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.3 M sodium formate and 0.4 M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.10 Å R-free 0.228 |
| 3CU1 Crystal Structure of 2:2:2 FGFR2D2:FGF1:SOS complex 提交 2008-04-15 | Assembly 1 其他组合 异源复合物；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 B
22–152（131 aa）
片段：UNP residues 22-152
链 D
22–152（131 aa）
片段：UNP residues 22-152
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；12% PEG3350, 4% Tacsimate, pH 7.0, vapor diffusion, hanging drop, temperature 298.0K
|
分辨率 2.60 Å R-free 0.277 |
| 3FGM Crystal structure of L44F/C83T/C117V/F132W mutant of Human acidic fibroblast growth factor 提交 2008-12-06 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L44F, C83T, C117V, F132W | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；4.1M Na-formate, 0.1M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.95 Å R-free 0.238 |
| 3FGM Crystal structure of L44F/C83T/C117V/F132W mutant of Human acidic fibroblast growth factor 提交 2008-12-06 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：L44F, C83T, C117V, F132W | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；4.1M Na-formate, 0.1M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.95 Å R-free 0.238 |
| 3FJ8 Crystal structure of C117I mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：C117I | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3M Na-formate, 0.7M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.00 Å R-free 0.231 |
| 3FJ8 Crystal structure of C117I mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：C117I | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3M Na-formate, 0.7M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.00 Å R-free 0.231 |
| 3FJ9 Crystal structure of F85W mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：F85W | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3M Na-formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.90 Å R-free 0.228 |
| 3FJ9 Crystal structure of F85W mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：F85W | FMT FORMIC ACID × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3M Na-formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.90 Å R-free 0.228 |
| 3FJA Crystal structure of F132W mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：F132W | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.4M Na formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.95 Å R-free 0.213 |
| 3FJA Crystal structure of F132W mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：F132W | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.4M Na formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.95 Å R-free 0.213 |
| 3FJB Crystal structure of V31I mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：V31I | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；2.5M Na formate, 0.7M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.00 Å R-free 0.233 |
| 3FJB Crystal structure of V31I mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：V31I | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；2.5M Na formate, 0.7M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.00 Å R-free 0.233 |
| 3FJC Crystal structure of L44W mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L44W | SO4 SULFATE ION × 1 FMT FORMIC ACID × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.0M Na-formate, 0.4M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.00 Å R-free 0.243 |
| 3FJC Crystal structure of L44W mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：L44W | FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.0M Na-formate, 0.4M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.00 Å R-free 0.243 |
| 3FJD Crystal structure of L44F/F132W mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L44F,F132W | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.0M Na-formate, 0.2M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.90 Å R-free 0.221 |
| 3FJD Crystal structure of L44F/F132W mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：L44F,F132W | FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.0M Na-formate, 0.2M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.90 Å R-free 0.221 |
| 3FJE Crystal structure of C83S mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：C83S | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.0M Na formate, 0.4M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.10 Å R-free 0.235 |
| 3FJE Crystal structure of C83S mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：C83S | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.0M Na formate, 0.4M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.10 Å R-free 0.235 |
| 3FJF Crystal structure of C83T mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：C83T | FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.3M Na formate, 0.4M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.90 Å R-free 0.224 |
| 3FJF Crystal structure of C83T mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：C83T | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.3M Na formate, 0.4M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.90 Å R-free 0.224 |
| 3FJH Crystal structure of C83A mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：C83A | SO4 SULFATE ION × 1 FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；2.7 M Na formate, 0.4M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.90 Å R-free 0.218 |
| 3FJH Crystal structure of C83A mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：C83A | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；2.7 M Na formate, 0.4M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.90 Å R-free 0.218 |
| 3FJI Crystal structure of K12V/C83I/C117V mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：K12V,C83I,C117V | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.0M Na formate, 0.1M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.55 Å R-free 0.263 |
| 3FJI Crystal structure of K12V/C83I/C117V mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：K12V,C83I,C117V | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.0M Na formate, 0.1M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.55 Å R-free 0.263 |
| 3FJI Crystal structure of K12V/C83I/C117V mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
16–155（140 aa）
|
突变：K12V,C83I,C117V | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.0M Na formate, 0.1M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.55 Å R-free 0.263 |
| 3FJI Crystal structure of K12V/C83I/C117V mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
16–155（140 aa）
|
突变：K12V,C83I,C117V | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.0M Na formate, 0.1M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.55 Å R-free 0.263 |
| 3FJJ Crystal structure of C83V mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：C83V | SO4 SULFATE ION × 1 FMT FORMIC ACID × 4 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.3 M Na formate, 0.4M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.90 Å R-free 0.233 |
| 3FJJ Crystal structure of C83V mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：C83V | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.3 M Na formate, 0.4M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.90 Å R-free 0.233 |
| 3FJK Crystal structure of A66C mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：A66C | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.3 M Na formate, 0.15M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.15 Å R-free 0.267 |
| 3FJK Crystal structure of A66C mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：A66C | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.3 M Na formate, 0.15M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.15 Å R-free 0.267 |
| 3FJK Crystal structure of A66C mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
16–155（140 aa）
|
突变：A66C | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.3 M Na formate, 0.15M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.15 Å R-free 0.267 |
| 3FJK Crystal structure of A66C mutant of Human acidic fibroblast growth factor 提交 2008-12-14 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
16–155（140 aa）
|
突变：A66C | FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.3 M Na formate, 0.15M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.15 Å R-free 0.267 |
| 3HOM Crystal structure of oxidized A66C mutant of Human acidic fibroblast growth factor 提交 2009-06-02 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：A81C | FMT FORMIC ACID × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.2M Na-formate, 0.15M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.30 Å R-free 0.234 |
| 3HOM Crystal structure of oxidized A66C mutant of Human acidic fibroblast growth factor 提交 2009-06-02 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：A81C | FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.2M Na-formate, 0.15M (NH4)2SO4, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.30 Å R-free 0.234 |
| 3JUT Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid 提交 2009-09-15 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
24–153（130 aa）
片段：Heparin-binding, UNP residues 24-153
|
未记录 | GTQ 2,5-dihydroxybenzoic acid × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.8；295 K；Equal volumes of protein and inhibitor solutions, 0.75 and 1.5 mM,respectively were mixed with drops containing 60% sodium/potassium tartrate buffered with 5 mM sodium phosphate [pH 7.8]. The drops were
equilibrated against 200 ml of 1.3M Li2SO4 and typical crystals grew within two weeks
, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
分辨率 2.25 Å R-free 0.274 |
| 3JUT Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid 提交 2009-09-15 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
24–153（130 aa）
片段：Heparin-binding, UNP residues 24-153
|
未记录 | GTQ 2,5-dihydroxybenzoic acid × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.8；295 K；Equal volumes of protein and inhibitor solutions, 0.75 and 1.5 mM,respectively were mixed with drops containing 60% sodium/potassium tartrate buffered with 5 mM sodium phosphate [pH 7.8]. The drops were
equilibrated against 200 ml of 1.3M Li2SO4 and typical crystals grew within two weeks
, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
分辨率 2.25 Å R-free 0.274 |
| 3JUT Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid 提交 2009-09-15 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
24–153（130 aa）
片段：Heparin-binding, UNP residues 24-153
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.8；295 K；Equal volumes of protein and inhibitor solutions, 0.75 and 1.5 mM,respectively were mixed with drops containing 60% sodium/potassium tartrate buffered with 5 mM sodium phosphate [pH 7.8]. The drops were
equilibrated against 200 ml of 1.3M Li2SO4 and typical crystals grew within two weeks
, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
分辨率 2.25 Å R-free 0.274 |
| 3JUT Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid 提交 2009-09-15 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
24–153（130 aa）
片段：Heparin-binding, UNP residues 24-153
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.8；295 K；Equal volumes of protein and inhibitor solutions, 0.75 and 1.5 mM,respectively were mixed with drops containing 60% sodium/potassium tartrate buffered with 5 mM sodium phosphate [pH 7.8]. The drops were
equilibrated against 200 ml of 1.3M Li2SO4 and typical crystals grew within two weeks
, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
分辨率 2.25 Å R-free 0.274 |
| 3JUT Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid 提交 2009-09-15 | Assembly 5 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 E
24–153（130 aa）
片段：Heparin-binding, UNP residues 24-153
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.8；295 K；Equal volumes of protein and inhibitor solutions, 0.75 and 1.5 mM,respectively were mixed with drops containing 60% sodium/potassium tartrate buffered with 5 mM sodium phosphate [pH 7.8]. The drops were
equilibrated against 200 ml of 1.3M Li2SO4 and typical crystals grew within two weeks
, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
分辨率 2.25 Å R-free 0.274 |
| 3JUT Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid 提交 2009-09-15 | Assembly 6 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 F
24–153（130 aa）
片段：Heparin-binding, UNP residues 24-153
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.8；295 K；Equal volumes of protein and inhibitor solutions, 0.75 and 1.5 mM,respectively were mixed with drops containing 60% sodium/potassium tartrate buffered with 5 mM sodium phosphate [pH 7.8]. The drops were
equilibrated against 200 ml of 1.3M Li2SO4 and typical crystals grew within two weeks
, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
分辨率 2.25 Å R-free 0.274 |
| 3K1X Acidic Fibroblast Growth Factor (FGF-1) complexed with dobesilate 提交 2009-09-29 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
24–153（130 aa）
片段：Heparin-binding, UNP residues 24-153
|
未记录 | DBX 2,5-dihydroxybenzenesulfonic acid × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.8；295 K；Crystals of thecomplex between FGF-1 and 2,5-DHPS (2,5-dihydroxyphenylsulfonate) were grown using the sitting drop vapour method at 295 K. Equal volumes of protein and inhibitor solutions, 0.75 and 1.5mM, respectively were mixed with drops containing 60% sodium/potassium tartrate buffered with 5mM sodium phosphate [pH 7.8]. The drops were equilibrated against 0.2ml of 1.3M Li2SO4 and typical crystals grew within two weeks with approximate dimensions of 0.7 x 0.5 x 0.2 mm.
, VAPOR DIFFUSION, SITTING DROP
|
分辨率 1.98 Å R-free 0.290 |
| 3K1X Acidic Fibroblast Growth Factor (FGF-1) complexed with dobesilate 提交 2009-09-29 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
24–153（130 aa）
片段：Heparin-binding, UNP residues 24-153
|
未记录 | DBX 2,5-dihydroxybenzenesulfonic acid × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.8；295 K；Crystals of thecomplex between FGF-1 and 2,5-DHPS (2,5-dihydroxyphenylsulfonate) were grown using the sitting drop vapour method at 295 K. Equal volumes of protein and inhibitor solutions, 0.75 and 1.5mM, respectively were mixed with drops containing 60% sodium/potassium tartrate buffered with 5mM sodium phosphate [pH 7.8]. The drops were equilibrated against 0.2ml of 1.3M Li2SO4 and typical crystals grew within two weeks with approximate dimensions of 0.7 x 0.5 x 0.2 mm.
, VAPOR DIFFUSION, SITTING DROP
|
分辨率 1.98 Å R-free 0.290 |
| 3K1X Acidic Fibroblast Growth Factor (FGF-1) complexed with dobesilate 提交 2009-09-29 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
24–153（130 aa）
片段：Heparin-binding, UNP residues 24-153
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.8；295 K；Crystals of thecomplex between FGF-1 and 2,5-DHPS (2,5-dihydroxyphenylsulfonate) were grown using the sitting drop vapour method at 295 K. Equal volumes of protein and inhibitor solutions, 0.75 and 1.5mM, respectively were mixed with drops containing 60% sodium/potassium tartrate buffered with 5mM sodium phosphate [pH 7.8]. The drops were equilibrated against 0.2ml of 1.3M Li2SO4 and typical crystals grew within two weeks with approximate dimensions of 0.7 x 0.5 x 0.2 mm.
, VAPOR DIFFUSION, SITTING DROP
|
分辨率 1.98 Å R-free 0.290 |
| 3K1X Acidic Fibroblast Growth Factor (FGF-1) complexed with dobesilate 提交 2009-09-29 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
24–153（130 aa）
片段：Heparin-binding, UNP residues 24-153
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.8；295 K；Crystals of thecomplex between FGF-1 and 2,5-DHPS (2,5-dihydroxyphenylsulfonate) were grown using the sitting drop vapour method at 295 K. Equal volumes of protein and inhibitor solutions, 0.75 and 1.5mM, respectively were mixed with drops containing 60% sodium/potassium tartrate buffered with 5mM sodium phosphate [pH 7.8]. The drops were equilibrated against 0.2ml of 1.3M Li2SO4 and typical crystals grew within two weeks with approximate dimensions of 0.7 x 0.5 x 0.2 mm.
, VAPOR DIFFUSION, SITTING DROP
|
分辨率 1.98 Å R-free 0.290 |
| 3K1X Acidic Fibroblast Growth Factor (FGF-1) complexed with dobesilate 提交 2009-09-29 | Assembly 5 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 E
24–153（130 aa）
片段：Heparin-binding, UNP residues 24-153
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.8；295 K；Crystals of thecomplex between FGF-1 and 2,5-DHPS (2,5-dihydroxyphenylsulfonate) were grown using the sitting drop vapour method at 295 K. Equal volumes of protein and inhibitor solutions, 0.75 and 1.5mM, respectively were mixed with drops containing 60% sodium/potassium tartrate buffered with 5mM sodium phosphate [pH 7.8]. The drops were equilibrated against 0.2ml of 1.3M Li2SO4 and typical crystals grew within two weeks with approximate dimensions of 0.7 x 0.5 x 0.2 mm.
, VAPOR DIFFUSION, SITTING DROP
|
分辨率 1.98 Å R-free 0.290 |
| 3K1X Acidic Fibroblast Growth Factor (FGF-1) complexed with dobesilate 提交 2009-09-29 | Assembly 6 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 F
24–153（130 aa）
片段：Heparin-binding, UNP residues 24-153
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.8；295 K；Crystals of thecomplex between FGF-1 and 2,5-DHPS (2,5-dihydroxyphenylsulfonate) were grown using the sitting drop vapour method at 295 K. Equal volumes of protein and inhibitor solutions, 0.75 and 1.5mM, respectively were mixed with drops containing 60% sodium/potassium tartrate buffered with 5mM sodium phosphate [pH 7.8]. The drops were equilibrated against 0.2ml of 1.3M Li2SO4 and typical crystals grew within two weeks with approximate dimensions of 0.7 x 0.5 x 0.2 mm.
, VAPOR DIFFUSION, SITTING DROP
|
分辨率 1.98 Å R-free 0.290 |
| 3O3Q Crystal structure of "L44F/M67I/L73V/A103G/deletion 104-106/F108Y/V109L/L111I/C117V/R119G/deletion 120-122" mutant form of Human acidic fibroblast growth factor 提交 2010-07-25 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：L44F, M67I, L73V, A103G, deletion 104-106, F108Y, V109L, L111I, C117V, R119G, deletion 120-122 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.2M magnesium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.60 Å R-free 0.203 |
| 3O3Q Crystal structure of "L44F/M67I/L73V/A103G/deletion 104-106/F108Y/V109L/L111I/C117V/R119G/deletion 120-122" mutant form of Human acidic fibroblast growth factor 提交 2010-07-25 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：L44F, M67I, L73V, A103G, deletion 104-106, F108Y, V109L, L111I, C117V, R119G, deletion 120-122 | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.2M magnesium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.60 Å R-free 0.203 |
| 3O3Q Crystal structure of "L44F/M67I/L73V/A103G/deletion 104-106/F108Y/V109L/L111I/C117V/R119G/deletion 120-122" mutant form of Human acidic fibroblast growth factor 提交 2010-07-25 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
16–155（140 aa）
|
突变：L44F, M67I, L73V, A103G, deletion 104-106, F108Y, V109L, L111I, C117V, R119G, deletion 120-122 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.2M magnesium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.60 Å R-free 0.203 |
| 3O3Q Crystal structure of "L44F/M67I/L73V/A103G/deletion 104-106/F108Y/V109L/L111I/C117V/R119G/deletion 120-122" mutant form of Human acidic fibroblast growth factor 提交 2010-07-25 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
16–155（140 aa）
|
突变：L44F, M67I, L73V, A103G, deletion 104-106, F108Y, V109L, L111I, C117V, R119G, deletion 120-122 | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.2M magnesium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.60 Å R-free 0.203 |
| 3OJ2 Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation 提交 2010-08-20 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–155（155 aa）
|
未记录 | SO4 SULFATE ION × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.1M Hepes, 20% PEG4000, 0.2M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
分辨率 2.20 Å R-free 0.294 |
| 3OJ2 Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation 提交 2010-08-20 | Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
1–155（155 aa）
|
未记录 | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.1M Hepes, 20% PEG4000, 0.2M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
分辨率 2.20 Å R-free 0.294 |
| 3OJM Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation 提交 2010-08-23 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–155（155 aa）
|
未记录 | SO4 SULFATE ION × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.1M Hepes, 22% monomethyl ether PEG5000, 0.2M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
分辨率 2.10 Å R-free 0.263 |
| 3OJV Crystal Structure of FGF1 complexed with the ectodomain of FGFR1c exhibiting an ordered ligand specificity-determining betaC'-betaE loop 提交 2010-08-23 | Assembly 1 其他组合 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
21–155（135 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1M Tris, 15% PEG4000, 0.1M ammonium sulfate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
分辨率 2.60 Å R-free 0.309 |
| 3OJV Crystal Structure of FGF1 complexed with the ectodomain of FGFR1c exhibiting an ordered ligand specificity-determining betaC'-betaE loop 提交 2010-08-23 | Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
21–155（135 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1M Tris, 15% PEG4000, 0.1M ammonium sulfate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
分辨率 2.60 Å R-free 0.309 |
| 3UD7 Crystal Structure Analysis of FGF1-Disaccharide(NI21) complexes 提交 2011-10-27 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
未记录 | PO4 PHOSPHATE ION × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2M (NH4)HPO4, 0.1M sodium acetate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.80 Å R-free 0.267 |
| 3UD7 Crystal Structure Analysis of FGF1-Disaccharide(NI21) complexes 提交 2011-10-27 | Assembly 2 其他组合 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
未记录 | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2M (NH4)HPO4, 0.1M sodium acetate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.80 Å R-free 0.267 |
| 3UD7 Crystal Structure Analysis of FGF1-Disaccharide(NI21) complexes 提交 2011-10-27 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
16–155（140 aa）
|
未记录 | PO4 PHOSPHATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2M (NH4)HPO4, 0.1M sodium acetate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.80 Å R-free 0.267 |
| 3UD8 Crystal Structure Analysis of FGF1-Disaccharide(NI22) complex 提交 2011-10-27 | Assembly 1 其他组合 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2 M (NH4)HPO4, 0.1 M sodium acetate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.37 Å R-free 0.270 |
| 3UD8 Crystal Structure Analysis of FGF1-Disaccharide(NI22) complex 提交 2011-10-27 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
未记录 | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2 M (NH4)HPO4, 0.1 M sodium acetate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.37 Å R-free 0.270 |
| 3UD8 Crystal Structure Analysis of FGF1-Disaccharide(NI22) complex 提交 2011-10-27 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
16–155（140 aa）
|
未记录 | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2 M (NH4)HPO4, 0.1 M sodium acetate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.37 Å R-free 0.270 |
| 3UD9 Crystal Structure Analysis of FGF1-Disaccharide(NI23) complex 提交 2011-10-27 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
未记录 | PO4 PHOSPHATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2M (NH4)HPO4, 0.1M sodium acetate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.34 Å R-free 0.252 |
| 3UD9 Crystal Structure Analysis of FGF1-Disaccharide(NI23) complex 提交 2011-10-27 | Assembly 2 其他组合 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2M (NH4)HPO4, 0.1M sodium acetate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.34 Å R-free 0.252 |
| 3UD9 Crystal Structure Analysis of FGF1-Disaccharide(NI23) complex 提交 2011-10-27 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
16–155（140 aa）
|
未记录 | PO4 PHOSPHATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2M (NH4)HPO4, 0.1M sodium acetate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.34 Å R-free 0.252 |
| 3UDA Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex 提交 2011-10-27 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2M (NH4)HPO4, 0.1M sodium acetate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.51 Å R-free 0.276 |
| 3UDA Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex 提交 2011-10-27 | Assembly 2 其他组合 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2M (NH4)HPO4, 0.1M sodium acetate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.51 Å R-free 0.276 |
| 3UDA Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex 提交 2011-10-27 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
16–155（140 aa）
|
未记录 | PO4 PHOSPHATE ION × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2M (NH4)HPO4, 0.1M sodium acetate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.51 Å R-free 0.276 |
| 4J23 Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex 提交 2013-02-04 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
21–155（135 aa）
片段：unp residues 21-155
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 3.88 Å R-free 0.384 |
| 4Q91 Crystal structure of C16A/K12V/C117V/P134V mutant of human acidic fibroblast growth factor 提交 2014-04-28 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
片段：UNP residues 16-155
|
突变：K12V/C16A/C117V/P134V | FMT FORMIC ACID × 2 PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.4 M sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.80 Å R-free 0.186 |
| 4Q91 Crystal structure of C16A/K12V/C117V/P134V mutant of human acidic fibroblast growth factor 提交 2014-04-28 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
片段：UNP residues 16-155
|
突变：K12V/C16A/C117V/P134V | FMT FORMIC ACID × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；3.4 M sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.80 Å R-free 0.186 |
| 4Q9G Crystal structure of K12V/C16S/C117V/P134V mutant of human acidic fibroblast growth factor 提交 2014-05-01 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
片段：UNP residues 16-155
|
突变：K12V/C16S/C117V/P134V | FMT FORMIC ACID × 2 PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；1.8 M sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.55 Å R-free 0.199 |
| 4Q9G Crystal structure of K12V/C16S/C117V/P134V mutant of human acidic fibroblast growth factor 提交 2014-05-01 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
片段：UNP residues 16-155
|
突变：K12V/C16S/C117V/P134V | FMT FORMIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；1.8 M sodium formate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.55 Å R-free 0.199 |
| 4Q9P Crystal structure of C16T/K12V/C117V/P134V mutant of human acidic fibroblast growth factor 提交 2014-05-01 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
片段：UNP residues 16-155
|
突变：K12V/C16T/C117V/P134V | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；1.0 M sodium citrate, 0.1 M imidazole, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.80 Å R-free 0.210 |
| 4Q9P Crystal structure of C16T/K12V/C117V/P134V mutant of human acidic fibroblast growth factor 提交 2014-05-01 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
片段：UNP residues 16-155
|
突变：K12V/C16T/C117V/P134V | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；1.0 M sodium citrate, 0.1 M imidazole, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.80 Å R-free 0.210 |
| 4QAL Crystal structure of C117A mutant of human acidic fibroblast growth factor 提交 2014-05-05 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
片段：UNP residues 16-155
|
突变：C117A | FLC CITRATE ANION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；0.7 M sodium citrate, 0.1 M imidazole, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.50 Å R-free 0.190 |
| 4QAL Crystal structure of C117A mutant of human acidic fibroblast growth factor 提交 2014-05-05 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
片段：UNP residues 16-155
|
突变：C117A | FLC CITRATE ANION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；0.7 M sodium citrate, 0.1 M imidazole, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.50 Å R-free 0.190 |
| 4QBC Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium formate buffer 提交 2014-05-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
片段：UNP residues 16-155
|
突变：C117T | SO4 SULFATE ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；4.0 M sodium formate, 0.45 M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.52 Å R-free 0.199 |
| 4QBC Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium formate buffer 提交 2014-05-07 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
片段：UNP residues 16-155
|
突变：C117T | FMT FORMIC ACID × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；4.0 M sodium formate, 0.45 M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.52 Å R-free 0.199 |
| 4QBV Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium citrate buffer 提交 2014-05-08 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
片段：UNP residues 16-155
|
突变：C117T | FLC CITRATE ANION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；0.9 M sodium citrate, 0.1 M imidazole, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.50 Å R-free 0.168 |
| 4QBV Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium citrate buffer 提交 2014-05-08 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
片段：UNP residues 16-155
|
突变：C117T | FLC CITRATE ANION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；0.9 M sodium citrate, 0.1 M imidazole, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 1.50 Å R-free 0.168 |
| 4QC4 Crystal structure of C117S mutant of human acidic fibroblast growth factor 提交 2014-05-09 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
片段：UNP residues 16-155
|
突变：C117S | FLC CITRATE ANION × 1 NA SODIUM ION × 1 IMD IMIDAZOLE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8.5；295 K；0.9 M sodium citrate, 0.1 M imidazole, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
分辨率 1.49 Å R-free 0.182 |
| 4QC4 Crystal structure of C117S mutant of human acidic fibroblast growth factor 提交 2014-05-09 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
片段：UNP residues 16-155
|
突变：C117S | FLC CITRATE ANION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8.5；295 K；0.9 M sodium citrate, 0.1 M imidazole, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
分辨率 1.49 Å R-free 0.182 |
| 4QO3 Crystal structure of C16S/N18S/K12V/C117V/P134V mutant of human acidic fibroblast growth factor 提交 2014-06-19 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
片段：UNP residues 16-155
|
突变：C16S/N18S/K12V/C117V/P134V | FLC CITRATE ANION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；0.9 M sodium citrate, 0.1 M imidazole, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.05 Å R-free 0.187 |
| 4QO3 Crystal structure of C16S/N18S/K12V/C117V/P134V mutant of human acidic fibroblast growth factor 提交 2014-06-19 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
片段：UNP residues 16-155
|
突变：C16S/N18S/K12V/C117V/P134V | FLC CITRATE ANION × 1 IMD IMIDAZOLE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；0.9 M sodium citrate, 0.1 M imidazole, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.05 Å R-free 0.187 |
| 4XKI Human Fibroblast Growth Factor - 1 (FGF-1) mutant S116R 提交 2015-01-12 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
|
突变：S116R | SO4 SULFATE ION × 2 PO4 PHOSPHATE ION × 3 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；2M ammonium sulfate, 2% v/v Polyethylene glycol 400 and 0.1 M sodium HEPES pH 7.5
|
分辨率 2.00 Å R-free 0.215 |
| 4XKI Human Fibroblast Growth Factor - 1 (FGF-1) mutant S116R 提交 2015-01-12 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
|
突变：S116R | PO4 PHOSPHATE ION × 5 2PE NONAETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；2M ammonium sulfate, 2% v/v Polyethylene glycol 400 and 0.1 M sodium HEPES pH 7.5
|
分辨率 2.00 Å R-free 0.215 |
| 4YOL Human fibroblast growth factor-1 C16S/A66C/C117A/P134A 提交 2015-03-11 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
16–155（140 aa）
片段：UNP residues 16-155
|
突变：C16S/A66C/C117A/P134A | FLC CITRATE ANION × 1 IMD IMIDAZOLE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；0.7 M sodium citrate, 0.1 M imidazole, pH 8.5
|
分辨率 1.97 Å R-free 0.199 |
| 4YOL Human fibroblast growth factor-1 C16S/A66C/C117A/P134A 提交 2015-03-11 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
16–155（140 aa）
片段：UNP residues 16-155
|
突变：C16S/A66C/C117A/P134A | FLC CITRATE ANION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；0.7 M sodium citrate, 0.1 M imidazole, pH 8.5
|
分辨率 1.97 Å R-free 0.199 |