当前蛋白身份:P51532 重新检索
本组结构的主要差异维度
构建体不同 突变/修饰不同 组装状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
2GRC 1.5 A structure of bromodomain from human BRG1 protein, a central ATPase of SWI/SNF remodeling complex 提交 2006-04-24 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1448–1575(128 aa) 片段:bromodomain, residues 1448-1575
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 8.5;298 K;0.1 M Tris, 25% w/v PEG 3350, pH 8.5, VAPOR DIFFUSION, temperature 298.0K
分辨率 1.50 Å R-free 0.264
2H60 Solution Structure of Human Brg1 Bromodomain 提交 2006-05-30 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1452–1570(119 aa) 片段:Bromodomain
未记录 未记录非水小分子 SOLUTION NMR
NMR测量条件 pH 6.4;293 K;离子强度(mmCIF原始值)100mM NaCl;压力 1
NMR样品组成 1mM Brg1 bromodomain U-15N, 13C; 25mM phosphate buffer; 100mM NaCl; 90% H2O, 10% D2O | 90% H2O/10% D2O
分辨率未提供
3UVD Crystal Structure of the bromodomain of human Transcription activator BRG1 (SMARCA4) in complex with N-Methyl-2-pyrrolidone 提交 2011-11-29 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1448–1569(122 aa) 片段:unp residues 1448-1569
未记录 MB3 1-methylpyrrolidin-2-one × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;277 K;28% MMW PEG smear 0.1M Tris.HCl pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
分辨率 1.85 Å R-free 0.262
5DKD Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with PFI-3 chemical probe 提交 2015-09-03 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1418–1536(119 aa) 片段:UNP residues 1418-1536
未记录 ZN ZINC ION × 1 EDO 1,2-ETHANEDIOL × 3 5BW (2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]hept-2-yl]prop-2-en-1-one × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.2;277.15 K;0.1 M Bis Tris pH 7.2, 0.1 M ammonium acetate, 0.1 M ZnCl2, 15% PEG smear high (mixture from PEG8k to 20k)
分辨率 2.00 Å R-free 0.297
5DKD Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with PFI-3 chemical probe 提交 2015-09-03 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 1418–1536(119 aa) 片段:UNP residues 1418-1536
未记录 ZN ZINC ION × 1 EDO 1,2-ETHANEDIOL × 3 5BW (2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]hept-2-yl]prop-2-en-1-one × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.2;277.15 K;0.1 M Bis Tris pH 7.2, 0.1 M ammonium acetate, 0.1 M ZnCl2, 15% PEG smear high (mixture from PEG8k to 20k)
分辨率 2.00 Å R-free 0.297
5EA1 Crystal Structure of SMARCA4 bromodomain in complex with MPD 提交 2015-10-15 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1451–1580(130 aa) 片段:Bromodomain, UNP residues 1451-1580
未记录 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;277 K;PEG1000 (12.5%), PEG3350 (12.5%), MPD (12.5%)
分辨率 2.00 Å R-free 0.228
5EA1 Crystal Structure of SMARCA4 bromodomain in complex with MPD 提交 2015-10-15 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 1451–1580(130 aa) 片段:Bromodomain, UNP residues 1451-1580
未记录 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;277 K;PEG1000 (12.5%), PEG3350 (12.5%), MPD (12.5%)
分辨率 2.00 Å R-free 0.228
5EA1 Crystal Structure of SMARCA4 bromodomain in complex with MPD 提交 2015-10-15 Assembly 3 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 1451–1580(130 aa) 片段:Bromodomain, UNP residues 1451-1580
未记录 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;277 K;PEG1000 (12.5%), PEG3350 (12.5%), MPD (12.5%)
分辨率 2.00 Å R-free 0.228
6HR2 Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB 提交 2018-09-26 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 1416–1535(120 aa)
未记录 FWZ (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide × 1 DMS DIMETHYL SULFOXIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6;277 K;20% (w/v) PEG1500, 0.1 M MIB Buffer, pH 6.0
分辨率 1.76 Å R-free 0.236
6HR2 Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB 提交 2018-09-26 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 E 1416–1535(120 aa)
未记录 FWZ (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide × 1 DMS DIMETHYL SULFOXIDE × 1 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6;277 K;20% (w/v) PEG1500, 0.1 M MIB Buffer, pH 6.0
分辨率 1.76 Å R-free 0.236
6LTH Structure of human BAF Base module 提交 2020-01-22 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 I 1–1647(1647 aa)
未记录 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.00 Å
6LTJ Structure of nucleosome-bound human BAF complex 提交 2020-01-22 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 18 PDB 声明:eicosameric(20) 与全部聚合物一致
链 I 1–1647(1647 aa)
未记录 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.70 Å
6ZS2 Crystal Structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol 提交 2020-07-15 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1418–1536(119 aa)
未记录 FX5 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol × 1 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;293 K;Crystallization buffer: 20% medium-molecular-weight PEG smear, 0.1 M Tris pH 8.5
分辨率 1.57 Å R-free 0.215
6ZS2 Crystal Structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol 提交 2020-07-15 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 1418–1536(119 aa)
未记录 FX5 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol × 1 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;293 K;Crystallization buffer: 20% medium-molecular-weight PEG smear, 0.1 M Tris pH 8.5
分辨率 1.57 Å R-free 0.215
7VDT The motor-nucleosome module of human chromatin remodeling PBAF-nucleosome complex 提交 2021-09-07 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 9 PDB 声明:undecameric(11) 与全部聚合物一致
链 A 160–1614(1455 aa)
未记录 BEF BERYLLIUM TRIFLUORIDE ION × 1 MG MAGNESIUM ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.80 Å
7VDV The overall structure of human chromatin remodeling PBAF-nucleosome complex 提交 2021-09-07 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 22 PDB 声明:24-meric(24) 与全部聚合物一致
链 A 160–1614(1455 aa)
未记录 BEF BERYLLIUM TRIFLUORIDE ION × 1 MG MAGNESIUM ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.40 Å
7Y8R The nucleosome-bound human PBAF complex 提交 2022-06-24 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 25 PDB 声明:27-meric(27) 与全部聚合物一致
链 I 1–1647(1647 aa)
未记录 ADP ADENOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 BEF BERYLLIUM TRIFLUORIDE ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.40 Å
8EB1 Chim2 - Intragenic antimicrobial peptide 提交 2022-08-30 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 874–878(5 aa)
未记录 未记录非水小分子 SOLUTION NMR
NMR测量条件 pH 7.4;298 K;离子强度(mmCIF原始值)PBS 10 mM;压力 1
NMR样品组成 1.28 mM peptide, 32 mM D-98% Dodecylphosphorylcholine-d38, 10 mM PBS, 90% H2O/10% D2O | 90% H2O/10% D2O
分辨率未提供
8G1Q Co-crystal structure of Compound 1 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB 提交 2023-02-02 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 H 1447–1569(123 aa)
未记录 NA SODIUM ION × 1 YHB N-(2-{4-[(6M)-3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl}pyridine-4-carbonyl)-3-methyl-L-valyl-(4R)-4-hydroxy-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamide × 1 PEG DI(HYDROXYETHYL)ETHER × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;PEG 300 0.1M Bis-Tris 6.5
分辨率 3.73 Å R-free 0.326
8QJR BRG1 bromodomain in complex with VBC via compound 17 提交 2023-09-13 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 G 1418–1536(119 aa) 片段:UNP residues 1418-1536
未记录 PO4 PHOSPHATE ION × 5 GOL GLYCEROL × 1 VLH (2S,4R)-1-[(2R)-2-[3-[2-[4-[3-[4-[(1R,5S)-3-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]pyridin-2-yl]oxycyclobutyl]oxypiperidin-1-yl]ethoxy]-1,2-oxazol-5-yl]-3-methyl-butanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;295 K;27 mM HEPES pH 6.8, 73 mM HEPES pH 8.6, 1.0 M NaI
分辨率 3.17 Å R-free 0.278
8QJR BRG1 bromodomain in complex with VBC via compound 17 提交 2023-09-13 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 H 1418–1536(119 aa) 片段:UNP residues 1418-1536
未记录 PO4 PHOSPHATE ION × 2 VLH (2S,4R)-1-[(2R)-2-[3-[2-[4-[3-[4-[(1R,5S)-3-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]pyridin-2-yl]oxycyclobutyl]oxypiperidin-1-yl]ethoxy]-1,2-oxazol-5-yl]-3-methyl-butanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide × 1 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;295 K;27 mM HEPES pH 6.8, 73 mM HEPES pH 8.6, 1.0 M NaI
分辨率 3.17 Å R-free 0.278
9DTX Crystal structure of PRT3789 in complex with the bromodomain of human BRG1 (SMARCA4) and pVHL:ElonginC:ElonginB 提交 2024-10-02 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 D 1448–1569(122 aa) 片段:UNP residues 1448-1569
未记录 A1BB4 (4R)-4-hydroxy-1-[(2R)-2-(3-{[(2S)-1-{(3R)-3-[(2M,6aS,11S)-2-(2-hydroxyphenyl)-5,6,6a,7,9,10-hexahydro-8H-pyrazino[1',2':4,5]pyrazino[2,3-c]pyridazin-8-yl]pyrrolidin-1-yl}propan-2-yl]oxy}-1,2-oxazol-5-yl)-3-methylbutanoyl]-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamide × 1 GOL GLYCEROL × 1 EDO 1,2-ETHANEDIOL × 1 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;291 K;0.1 M Bis-Tris propane, pH 8.5, 0.2 M potassium thiocyanate, 20% w/v PEG3350
分辨率 2.11 Å R-free 0.232
9RL4 Structure of BAF in complex with OCT4-SOX2-bound nucleosome - SHL-6 提交 2025-06-16 Assembly 1 信息不足 异源复合物;蛋白 × 20 PDB 声明:22-meric(22) 与全部聚合物一致
链 I 1–1647(1647 aa)
未记录 PTD PENTANEDIAL × 16 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.50 Å
9RMC Structure of BAF in complex with OCT4-SOX2-bound nucleosome - SHL+6 class 1 提交 2025-06-18 Assembly 1 信息不足 异源复合物;蛋白 × 20 PDB 声明:22-meric(22) 与全部聚合物一致
链 I 1–1647(1647 aa)
未记录 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.20 Å
9RN1 Structure of BAF-nucleosome complex with OCT4-SOX2 at SHL+6 in ADP-bound state, BAF47 bound to ATPase lobe 2 提交 2025-06-19 Assembly 1 信息不足 异源复合物;蛋白 × 20 PDB 声明:22-meric(22) 与全部聚合物一致
链 I 1–1647(1647 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 5.90 Å
9RN2 Structure of BAF in complex with OCT4-SOX2-bound nucleosome - SHL+6 class 2 提交 2025-06-19 Assembly 1 信息不足 异源复合物;蛋白 × 19 PDB 声明:21-meric(21) 与全部聚合物一致
链 I 1–1647(1647 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.10 Å
9UX9 local ATPase-NCP structure of the ncBAF-nucleosome complex in the ADP-BeFx-bound state 提交 2025-05-13 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 9 PDB 声明:11-meric(11) 与全部聚合物一致
链 K 2–1647(1646 aa)
未记录 BEF BERYLLIUM TRIFLUORIDE ION × 1 MG MAGNESIUM ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.05 Å
9UXA local ARP-NCP structure of the ncBAF-nucleosome complex in the apo state 提交 2025-05-13 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 12 PDB 声明:14-meric(14) 与全部聚合物一致
链 K 2–1647(1646 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.28 Å
9UXB The apo structure of BCL7B-containing ARP module of the human SWI/SNF complex 提交 2025-05-13 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 446–517(72 aa)
未记录 MG MAGNESIUM ION × 2 ATP ADENOSINE-5'-TRIPHOSPHATE × 2 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.92 Å
9UXC The ADP-bound structure of BCL7B-containing ARP module of the human SWI/SNF complex 提交 2025-05-13 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 446–517(72 aa)
未记录 MG MAGNESIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.74 Å
9WBZ The structure of NCP-motor-ARP module of ncBAF-nucleosome complex 提交 2025-08-15 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 12 PDB 声明:tetradecameric(14) 与全部聚合物一致
链 A 1–1614(1614 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.90 Å
9WC1 The structure of ARP module in ncBAF complex 提交 2025-08-15 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 D 1–1614(1614 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.40 Å