3pgw

Crystal structure of human U1 snRNP

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

U1-A

OrganismNot specified

UniProt P09012

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-70K × 1 (P08621) Sm-D3 × 1 (P62318) Sm B × 1 (Q66K91) Sm-D1 × 1 (P62314) Sm-D2 × 1 (P62316) Sm-F × 1 (P62306) Sm-E × 1 (P62304) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers
2 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-70K × 1 (P08621) Sm-D3 × 1 (P62318) Sm B × 1 (Q66K91) Sm-D1 × 1 (P62314) Sm-D2 × 1 (P62316) Sm-F × 1 (P62306) Sm-E × 1 (P62304) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SNRPA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 1–282; UniProt 1–282 Author chain P; PDBConstruct 1–282; UniProt 1–282

U1-70K

OrganismNot specified

UniProt P08621

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) Sm-D3 × 1 (P62318) Sm B × 1 (Q66K91) Sm-D1 × 1 (P62314) Sm-D2 × 1 (P62316) Sm-F × 1 (P62306) Sm-E × 1 (P62304) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers
2 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) Sm-D3 × 1 (P62318) Sm B × 1 (Q66K91) Sm-D1 × 1 (P62314) Sm-D2 × 1 (P62316) Sm-F × 1 (P62306) Sm-E × 1 (P62304) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RU17_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain L; PDBConstruct 1–437; UniProt 1–437 Author chain S; PDBConstruct 1–437; UniProt 1–437

Sm-D3

OrganismNot specified

UniProt P62318

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) U1-70K × 1 (P08621) Sm B × 1 (Q66K91) Sm-D1 × 1 (P62314) Sm-D2 × 1 (P62316) Sm-F × 1 (P62306) Sm-E × 1 (P62304) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers
2 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) U1-70K × 1 (P08621) Sm B × 1 (Q66K91) Sm-D1 × 1 (P62314) Sm-D2 × 1 (P62316) Sm-F × 1 (P62306) Sm-E × 1 (P62304) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SMD3_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain W; PDBConstruct 1–126; UniProt 1–126 Author chain Z; PDBConstruct 1–126; UniProt 1–126

Sm B

OrganismNot specified

UniProt Q66K91

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) U1-70K × 1 (P08621) Sm-D3 × 1 (P62318) Sm-D1 × 1 (P62314) Sm-D2 × 1 (P62316) Sm-F × 1 (P62306) Sm-E × 1 (P62304) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers
2 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) U1-70K × 1 (P08621) Sm-D3 × 1 (P62318) Sm-D1 × 1 (P62314) Sm-D2 × 1 (P62316) Sm-F × 1 (P62306) Sm-E × 1 (P62304) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name Q66K91_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain B; PDBConstruct 1–231; UniProt 1–231 Author chain Q; PDBConstruct 1–231; UniProt 1–231

Sm-D1

OrganismNot specified

UniProt P62314

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) U1-70K × 1 (P08621) Sm-D3 × 1 (P62318) Sm B × 1 (Q66K91) Sm-D2 × 1 (P62316) Sm-F × 1 (P62306) Sm-E × 1 (P62304) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers
2 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) U1-70K × 1 (P08621) Sm-D3 × 1 (P62318) Sm B × 1 (Q66K91) Sm-D2 × 1 (P62316) Sm-F × 1 (P62306) Sm-E × 1 (P62304) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SMD1_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain U; PDBConstruct 1–119; UniProt 1–119 Author chain X; PDBConstruct 1–119; UniProt 1–119

Sm-D2

OrganismNot specified

UniProt P62316

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) U1-70K × 1 (P08621) Sm-D3 × 1 (P62318) Sm B × 1 (Q66K91) Sm-D1 × 1 (P62314) Sm-F × 1 (P62306) Sm-E × 1 (P62304) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers
2 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) U1-70K × 1 (P08621) Sm-D3 × 1 (P62318) Sm B × 1 (Q66K91) Sm-D1 × 1 (P62314) Sm-F × 1 (P62306) Sm-E × 1 (P62304) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SMD2_HUMAN
Isoform —
PDB entities 6
Chains and sequence ranges Author chain V; PDBConstruct 1–118; UniProt 1–118 Author chain Y; PDBConstruct 1–118; UniProt 1–118

Sm-F

OrganismNot specified

UniProt P62306

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) U1-70K × 1 (P08621) Sm-D3 × 1 (P62318) Sm B × 1 (Q66K91) Sm-D1 × 1 (P62314) Sm-D2 × 1 (P62316) Sm-E × 1 (P62304) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers
2 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) U1-70K × 1 (P08621) Sm-D3 × 1 (P62318) Sm B × 1 (Q66K91) Sm-D1 × 1 (P62314) Sm-D2 × 1 (P62316) Sm-E × 1 (P62304) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RUXF_HUMAN
Isoform —
PDB entities 7
Chains and sequence ranges Author chain F; PDBConstruct 1–86; UniProt 1–86 Author chain I; PDBConstruct 1–86; UniProt 1–86

Sm-E

OrganismNot specified

UniProt P62304

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) U1-70K × 1 (P08621) Sm-D3 × 1 (P62318) Sm B × 1 (Q66K91) Sm-D1 × 1 (P62314) Sm-D2 × 1 (P62316) Sm-F × 1 (P62306) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers
2 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) U1-70K × 1 (P08621) Sm-D3 × 1 (P62318) Sm B × 1 (Q66K91) Sm-D1 × 1 (P62314) Sm-D2 × 1 (P62316) Sm-F × 1 (P62306) Sm G × 1 (D6W5G6) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RUXE_HUMAN
Isoform —
PDB entities 8
Chains and sequence ranges Author chain E; PDBConstruct 1–92; UniProt 1–92 Author chain H; PDBConstruct 1–92; UniProt 1–92

Sm G

OrganismNot specified

UniProt D6W5G6

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) U1-70K × 1 (P08621) Sm-D3 × 1 (P62318) Sm B × 1 (Q66K91) Sm-D1 × 1 (P62314) Sm-D2 × 1 (P62316) Sm-F × 1 (P62306) Sm-E × 1 (P62304) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers
2 Other combination Heteromer Protein 9 DNA 1 RNA 1 U1-A × 1 (P09012) U1-70K × 1 (P08621) Sm-D3 × 1 (P62318) Sm B × 1 (Q66K91) Sm-D1 × 1 (P62314) Sm-D2 × 1 (P62316) Sm-F × 1 (P62306) Sm-E × 1 (P62304) U1 snRNA × 1 ;DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3' ; × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name D6W5G6_HUMAN
Isoform —
PDB entities 9
Chains and sequence ranges Author chain G; PDBConstruct 1–76; UniProt 1–76 Author chain J; PDBConstruct 1–76; UniProt 1–76

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3pgw
Deposition date deposition_date2010-11-02
Structure title titleCrystal structure of human U1 snRNP
Keywords keywordsPROTEIN-RNA COMPLEX, U1 snRNA, Sm fold, Sm core, RRM, Splicing, mRNA, snRNPs, splicing factors, splicing-DNA-RNA complex; splicing/DNA/RNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3pgw__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3pgw__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3pgw__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)44.28 Å
Rg (electron density)44.59 Å
Total Rg44.39 Å
Atom count171
Residues171
Excluded volume123210 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3pgw__assembly_1__model_1 undecameric (11) Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 3pgw__assembly_2__model_1 undecameric (11) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (11)

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7. Citations (1)