Transcription factor ETV6
Homo sapiens
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain A； UniProt 43–125 | Fragment：PNT domain Mutation：A93D,V112E | FMT FORMIC ACID × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 7；298.15 K；2.8 M Sodium Acetate | Resolution 1.85 Å R-free 0.234 |
| 2 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain B； UniProt 43–125 | Fragment：PNT domain Mutation：A93D,V112E | FMT FORMIC ACID × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 7；298.15 K；2.8 M Sodium Acetate | Resolution 1.85 Å R-free 0.234 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 7JU2 | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1JI7 Crystal Structure of TEL SAM Polymer Deposited 2001-06-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
47–123（77 aa）
Fragment：TEL SAM domain
Chain B
47–123（77 aa）
Fragment：TEL SAM domain
Chain C
47–123（77 aa）
Fragment：TEL SAM domain
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | SO4 SULFATE ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；Li2SO4, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.45 Å R-free 0.195 |
| 1LKY Structure of the wild-type TEL-SAM polymer Deposited 2002-04-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
47–123（77 aa）
Fragment：Pointed domain
Chain B
47–123（77 aa）
Fragment：Pointed domain
Chain C
47–123（77 aa）
Fragment：Pointed domain
Chain D
47–123（77 aa）
Fragment：Pointed domain
Chain E
47–123（77 aa）
Fragment：Pointed domain
Chain F
47–123（77 aa）
Fragment：Pointed domain
|
Mutation：V80R Mutation：A61D Mutation：V80R Mutation：A61D Mutation：V80R Mutation：A61D | SO4 SULFATE ION × 11 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；5% PEG 4000 2.0 M ammonium sulfate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.30 Å R-free 0.283 |
| 1LKY Structure of the wild-type TEL-SAM polymer Deposited 2002-04-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
47–123（77 aa）
Fragment：Pointed domain
Chain B
47–123（77 aa）
Fragment：Pointed domain
Chain C
47–123（77 aa）
Fragment：Pointed domain
Chain D
47–123（77 aa）
Fragment：Pointed domain
Chain E
47–123（77 aa）
Fragment：Pointed domain
Chain F
47–123（77 aa）
Fragment：Pointed domain
|
Mutation：V80R Mutation：A61D Mutation：V80R Mutation：A61D Mutation：V80R Mutation：A61D | SO4 SULFATE ION × 11 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；5% PEG 4000 2.0 M ammonium sulfate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.30 Å R-free 0.283 |
| 1LKY Structure of the wild-type TEL-SAM polymer Deposited 2002-04-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
47–123（77 aa）
Fragment：Pointed domain
Chain B
47–123（77 aa）
Fragment：Pointed domain
Chain C
47–123（77 aa）
Fragment：Pointed domain
Chain D
47–123（77 aa）
Fragment：Pointed domain
Chain E
47–123（77 aa）
Fragment：Pointed domain
Chain F
47–123（77 aa）
Fragment：Pointed domain
|
Mutation：V80R Mutation：A61D Mutation：V80R Mutation：A61D Mutation：V80R Mutation：A61D | SO4 SULFATE ION × 11 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；5% PEG 4000 2.0 M ammonium sulfate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.30 Å R-free 0.283 |
| 1LKY Structure of the wild-type TEL-SAM polymer Deposited 2002-04-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
47–123（77 aa）
Fragment：Pointed domain
Chain B
47–123（77 aa）
Fragment：Pointed domain
Chain C
47–123（77 aa）
Fragment：Pointed domain
Chain D
47–123（77 aa）
Fragment：Pointed domain
Chain E
47–123（77 aa）
Fragment：Pointed domain
Chain F
47–123（77 aa）
Fragment：Pointed domain
|
Mutation：V80R Mutation：A61D Mutation：V80R Mutation：A61D Mutation：V80R Mutation：A61D | SO4 SULFATE ION × 11 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；5% PEG 4000 2.0 M ammonium sulfate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.30 Å R-free 0.283 |
| 1LKY Structure of the wild-type TEL-SAM polymer Deposited 2002-04-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
47–123（77 aa）
Fragment：Pointed domain
Chain B
47–123（77 aa）
Fragment：Pointed domain
Chain C
47–123（77 aa）
Fragment：Pointed domain
Chain D
47–123（77 aa）
Fragment：Pointed domain
Chain E
47–123（77 aa）
Fragment：Pointed domain
Chain F
47–123（77 aa）
Fragment：Pointed domain
|
Mutation：V80R Mutation：A61D Mutation：V80R Mutation：A61D Mutation：V80R Mutation：A61D | SO4 SULFATE ION × 11 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；5% PEG 4000 2.0 M ammonium sulfate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.30 Å R-free 0.283 |
| 2DAO Solution structure of ETS domain Transcriptional factor ETV6 protein Deposited 2005-12-14 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
338–442（105 aa）
Fragment：ETS domain
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 7；296 K；Ionic strength (raw mmCIF value) 120；Pressure ambient
NMR sample composition
1.19mM ETS domain U-15N, 13C; 20mM d-Tris-HCl(pH 7.0); 100mM NaCl; 1mM d-DTT; 0.02% NaN3; 90%H2O, 10%D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2QB0 Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker. Deposited 2007-06-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
47–123（77 aa）
Chain D
47–123（77 aa）
|
Mutation：E80V | MN MANGANESE (II) ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.56 Å R-free 0.252 |
| 2QB0 Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker. Deposited 2007-06-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
47–123（77 aa）
Chain C
47–123（77 aa）
|
Mutation：E80V | MN MANGANESE (II) ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.56 Å R-free 0.252 |
| 5L0P Symmetry-based assembly of a two-dimensional protein lattice Deposited 2016-07-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
47–124（78 aa）
Fragment：3 x TelSAM (UNP residues 47-124) + FUR (UNP residues 3-83) with connecting linkers
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；290 K；100 mM Tris, pH 8.0, 3.5 M sodium chloride
|
Resolution 2.30 Å R-free 0.236 |
| 7N1O The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone Deposited 2021-05-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
46–123（78 aa）
|
Mutation：1TEL: R41A,D46G,V112E,K122A,vWa: R49A,C175A,V112A,K112A | MG MAGNESIUM ION × 1 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.7；298 K；100 mM BisTris, 3.0 M NaCl
|
Resolution 2.77 Å R-free 0.228 |
| 7N2B A DARPin semi-rigidly fused to the 3TEL crystallization chaperone Deposited 2021-05-28 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–121（75 aa）
Chain A
47–124（78 aa）
|
Mutation：V67E Mutation：V67E | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.4；298 K；200 mM L-Proline, 100 mM HEPES, 10 % w/v Polyethylene glycol 3350
|
Resolution 3.22 Å R-free 0.242 |
| 7N2B A DARPin semi-rigidly fused to the 3TEL crystallization chaperone Deposited 2021-05-28 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
47–121（75 aa）
Chain B
47–124（78 aa）
|
Mutation：V67E Mutation：V67E | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.4；298 K；200 mM L-Proline, 100 mM HEPES, 10 % w/v Polyethylene glycol 3350
|
Resolution 3.22 Å R-free 0.242 |
| 7T8J The ubiquitin-associated domain of human thirty-eight negative kinase-1 flexibly fused to the 1TEL crystallization chaperone via a GSGG linker Deposited 2021-12-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–121（75 aa）
|
Mutation：R80S,V112E,C610A,C644A | CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；1.2 uL of 1 mg/mL protein in 50 mM Tris pH 8.8, 200 mM KCl combined with 1.2 uL of 100 mM Bis-tris-propane, 2.5 M Ammonium Nitrate
|
Resolution 1.89 Å R-free 0.235 |
| 7TDY The ubiquitin-associated domain of human thirty-eight negative kinase 1, flexibly fused to the 1TEL crystallization chaperone via a 2-glycine linker and crystallized at low protein concentration Deposited 2022-01-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–120（74 aa）
|
Mutation：R80S,V112E,C610A,C644A | FMT FORMIC ACID × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；1.2 uL of 2 mg/mL protein combined with 1.2 uL of 100 mM Bis-Tris, pH 7.00, 250 mM Mg-Formate.
|
Resolution 1.53 Å R-free 0.217 |
| 7TW7 Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SAM Deposited 2022-02-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–123（77 aa）
|
Mutation：A4R, E67V, A77K | ZN ZINC ION × 1 SAM S-ADENOSYLMETHIONINE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；293.15 K；11-17% Reagent Alcohol, 0.1-0.3M Lithium Sulfate, and 0.1M Sodium Citrate pH 5.5
|
Resolution 1.62 Å R-free 0.218 |
| 7TW8 Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SAH Deposited 2022-02-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–123（77 aa）
|
Mutation：A4R, E67V, A77K | SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；293.15 K；11-17% Reagent Alcohol, 0.1-0.3M Lithium Sulfate and 0.1M Sodium Citrate pH 5.5
|
Resolution 1.55 Å R-free 0.206 |
| 7TW9 Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to Sinefungin Deposited 2022-02-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–123（77 aa）
|
Mutation：A4R, E67V, A77K | SFG SINEFUNGIN × 1 ZN ZINC ION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 EOH ETHANOL × 1 MOH METHANOL × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；293.15 K；11-17% Reagent Alcohol, 0.1-0.3M Lithium Sulfate, and 0.1M Sodium Citrate pH 5.5
|
Resolution 1.41 Å R-free 0.232 |
| 7U4W The ubiquitin-associated domain of human thirty-eight negative kinase-1 flexibly fused to the 1TEL crystallization chaperone via a 2-glycine linker and crystallized at traditional protein concentration Deposited 2022-03-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–121（75 aa）
|
Mutation：R80S,V112E,C610A,C644A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；298 K；1.2 uL of 15 mg/mL protein combined with 1.2 uL of 100 mM Bis-Tris, pH 6.50, 750 mM Mg-Formate
|
Resolution 2.10 Å R-free 0.276 |
| 7U4Z The ubiquitin-associated domain of human thirty-eight negative kinase-1 flexibly fused to the 1TEL crystallization chaperone via a 2-glycine linker and crystallized at very low protein concentration Deposited 2022-03-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–121（75 aa）
|
Mutation：R80S,V112E,C610A,C644A | K POTASSIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；1.2 uL of 0.5 mg/mL protein combined with 1.2 uL of 100 mM Bis-Tris, pH 6.00, 630-750 mM Mg-Formate.
|
Resolution 2.03 Å R-free 0.232 |
| 8BWU Crystal structure of SARS-CoV-2 nsp14 methyltransferase domain in complex with the SS148 inhibitor Deposited 2022-12-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–123（77 aa）
|
Not recorded | 6NR (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid × 1 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；100 mM bicine/Trizma pH 8.5;
10% w/v PEG 20.000, 20% v/v PEG MME 550;
20 mM D-glucose, 20 mM D-mannose, 20 mM D-galactose, 20 mM L-fucose, 20 mM D-xylose, 20 mM N-acetyl-D-glucosamine
|
Resolution 2.36 Å R-free 0.264 |
| 8E1F Sterile Alpha Motif Domain of Human Translocation ETS Leukemia, Non-Polymer Crystal Form Deposited 2022-08-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–124（78 aa）
Fragment：Sterile Alpha Motif Domain, residues 47-126
|
Mutation：R35S, V67E | CL CHLORIDE ION × 1 SO4 SULFATE ION × 1 MG MAGNESIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.9；298 K；200mM MgSO4 Heptahydrate, 20% w/v Polyethylene Glycol 3,350
|
Resolution 2.16 Å R-free 0.229 |
| 8E1F Sterile Alpha Motif Domain of Human Translocation ETS Leukemia, Non-Polymer Crystal Form Deposited 2022-08-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
47–124（78 aa）
Fragment：Sterile Alpha Motif Domain, residues 47-126
|
Mutation：R35S, V67E | CL CHLORIDE ION × 1 SO4 SULFATE ION × 1 MG MAGNESIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.9；298 K；200mM MgSO4 Heptahydrate, 20% w/v Polyethylene Glycol 3,350
|
Resolution 2.16 Å R-free 0.229 |
| 8E1F Sterile Alpha Motif Domain of Human Translocation ETS Leukemia, Non-Polymer Crystal Form Deposited 2022-08-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
47–124（78 aa）
Fragment：Sterile Alpha Motif Domain, residues 47-126
|
Mutation：R35S, V67E | CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.9；298 K；200mM MgSO4 Heptahydrate, 20% w/v Polyethylene Glycol 3,350
|
Resolution 2.16 Å R-free 0.229 |
| 8E1F Sterile Alpha Motif Domain of Human Translocation ETS Leukemia, Non-Polymer Crystal Form Deposited 2022-08-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
47–124（78 aa）
Fragment：Sterile Alpha Motif Domain, residues 47-126
|
Mutation：R35S, V67E | MG MAGNESIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.9；298 K；200mM MgSO4 Heptahydrate, 20% w/v Polyethylene Glycol 3,350
|
Resolution 2.16 Å R-free 0.229 |
| 8FRJ Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SGC0946 Deposited 2023-01-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–123（77 aa）
|
Mutation：A4R, E67V, A77K | ZN ZINC ION × 1 AW2 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；293.15 K；11-17% Reagent Alcohol, 0.1-0.3M Lithium Sulfate and 0.1M Sodium Citrate pH 5.5
|
Resolution 1.57 Å R-free 0.204 |
| 8FRK Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SGC8158 Deposited 2023-01-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–123（77 aa）
|
Mutation：A4R,E67V,A77K | ZN ZINC ION × 1 EOH ETHANOL × 1 MJ7 5'-S-(4-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}butyl)-5'-thioadenosine × 1 K POTASSIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；293.15 K；11-17% Reagent Alcohol, 0.1-0.3M Lithium Sulfate and 0.1M Sodium Citrate pH 5.5
|
Resolution 1.61 Å R-free 0.251 |
| 8FT6 The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Ala-Ala linker variant, SUMO tag-free preparation. Deposited 2023-01-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–124（78 aa）
|
Mutation：R14A,V77E,K87A,R89A,R91A,A225V | CIT CITRIC ACID × 1 IOD IODIDE ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；0.2M Ammonium citrate tribasic, 20% w/v PEG 3350
|
Resolution 2.62 Å R-free 0.234 |
| 8FT8 The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Thr-Val linker variant, SUMO tag-free preparation Deposited 2023-01-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–124（78 aa）
|
Mutation：R14A,V77E,K87A,R89A,R91T,A92V,A225V | GOL GLYCEROL × 1 CL CHLORIDE ION × 3 K POTASSIUM ION × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；0.1M HEPES, 2.0M ammonium sulfate
|
Resolution 1.60 Å R-free 0.204 |
| 8FZ3 Sterile Alpha Motif of Human Translocation ETS Leukemia, Non-Polymer Crystal Form Deposited 2023-01-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–123（77 aa）
|
Mutation：R45S, V77E | CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；298 K；1.4 M Sodium phosphate monobasic monohydrate/Potassium phosphate dibasic pH 8.2
|
Resolution 2.78 Å R-free 0.267 |
| 8FZ3 Sterile Alpha Motif of Human Translocation ETS Leukemia, Non-Polymer Crystal Form Deposited 2023-01-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
47–123（77 aa）
|
Mutation：R45S, V77E | PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；298 K；1.4 M Sodium phosphate monobasic monohydrate/Potassium phosphate dibasic pH 8.2
|
Resolution 2.78 Å R-free 0.267 |
| 8FZ3 Sterile Alpha Motif of Human Translocation ETS Leukemia, Non-Polymer Crystal Form Deposited 2023-01-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
47–123（77 aa）
|
Mutation：R45S, V77E | CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；298 K；1.4 M Sodium phosphate monobasic monohydrate/Potassium phosphate dibasic pH 8.2
|
Resolution 2.78 Å R-free 0.267 |
| 8FZ3 Sterile Alpha Motif of Human Translocation ETS Leukemia, Non-Polymer Crystal Form Deposited 2023-01-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
47–123（77 aa）
|
Mutation：R45S, V77E | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；298 K；1.4 M Sodium phosphate monobasic monohydrate/Potassium phosphate dibasic pH 8.2
|
Resolution 2.78 Å R-free 0.267 |
| 8FZU The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Thr-Val linker variant, Expressed with SUMO tag Deposited 2023-01-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–111（65 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；0.1M HEPES 2.0M ammonium sulfate
|
Resolution 1.90 Å R-free 0.266 |
| 8FZU The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Thr-Val linker variant, Expressed with SUMO tag Deposited 2023-01-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
47–111（65 aa）
|
Not recorded | K POTASSIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；0.1M HEPES 2.0M ammonium sulfate
|
Resolution 1.90 Å R-free 0.266 |
| 8FZU The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Thr-Val linker variant, Expressed with SUMO tag Deposited 2023-01-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
47–111（65 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；0.1M HEPES 2.0M ammonium sulfate
|
Resolution 1.90 Å R-free 0.266 |
| 8FZV The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Ala-Ala linker variant, expressed with SUMO tag Deposited 2023-01-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–111（65 aa）
|
Not recorded | MG MAGNESIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；298 K；100 mM sodium acetate, pH
4.6, 2.0 M sodium formate
|
Resolution 3.29 Å R-free 0.314 |
| 8FZV The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Ala-Ala linker variant, expressed with SUMO tag Deposited 2023-01-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
47–111（65 aa）
|
Not recorded | UNX UNKNOWN LIGAND × 32 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；298 K；100 mM sodium acetate, pH
4.6, 2.0 M sodium formate
|
Resolution 3.29 Å R-free 0.314 |
| 8FZV The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Ala-Ala linker variant, expressed with SUMO tag Deposited 2023-01-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
47–111（65 aa）
|
Not recorded | UNX UNKNOWN LIGAND × 58 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；298 K；100 mM sodium acetate, pH
4.6, 2.0 M sodium formate
|
Resolution 3.29 Å R-free 0.314 |
| 8THA 1TEL, non-compressed, double-helical crystal form Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–124（78 aa）
|
Mutation：V112E,R80S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.5 M Bis-Tris, 0.35 M Mg-Formate, 5 mg/mL protein
|
Resolution 1.68 Å R-free 0.215 |
| 9CPL The ubiquitin-associated domain of human thirty-eight negative kinase 1, fused to the 2TEL crystallization chaperone via a 2-glycine linker Deposited 2024-07-18 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–124（78 aa）
Chain A
47–121（75 aa）
|
Mutation：First TELSAM:R80S,V112E,Second TELSAM: R80S,UBA Domain: C610A,C644A Mutation：First TELSAM:R80S,V112E,Second TELSAM: R80S,UBA Domain: C610A,C644A | FMT FORMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；100mM BisTris, pH 6.0, 960mM Mg-formate
|
Resolution 2.40 Å R-free 0.263 |
| 9DB5 A DARPin fused to the 1TEL crystallization chaperone via a proline-alanine linker Deposited 2024-08-23 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–121（75 aa）
Fragment：residues 47-121 (Uniprot numbering) of Transcription factor ETV6
|
Not recorded | ACY ACETIC ACID × 13 NA SODIUM ION × 8 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.6；294 K；4.0 M Ammonium acetate, 0.1 M Sodium acetate trihydrate
|
Resolution 1.57 Å R-free 0.196 |
| 9DOC The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Thr-Val linker variant, at 1.2 Angstrom resolution Deposited 2024-09-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–121（75 aa）
Fragment：von Willebrand factor A domain of CMG2
|
Mutation：TELSAM: R80S,V112E (Uniprot numbering),vWA: C175A (Uniprot numbering) | GOL GLYCEROL × 1 PO4 PHOSPHATE ION × 2 MG MAGNESIUM ION × 7 NA SODIUM ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.25；298 K；100 mM Bis-Tris, pH 7.25, 1350 mM Sodium Potassium Phosphate
|
Resolution 1.19 Å R-free 0.197 |
| 9DP8 A DARPin fused to the 1TEL crystallization chaperone via a helical Lys-Gln-Arg linker Deposited 2024-09-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–124（78 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 5.5；298 K；0.1 M BIS-TRIS pH 5.5, 0.3 M Magnesium formate dihydrate
|
Resolution 3.47 Å R-free 0.298 |
| 9DVG Crystal Structure of a DARPin Fused to the 1TEL Crystallization Chaperone via a Direct Helical Fusion in a 2-Fold Crystal Form Deposited 2024-10-07 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–121（75 aa）
|
Mutation：V112E in ETV6 (Uniprot numbering) | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；298 K；1.5 M Ammonium Phosphate Dibasic, 0.1 M Tris
|
Resolution 3.54 Å R-free 0.301 |
| 9E4Q A DARPin fused to the 3TEL crystallization chaperone via a gly-gly-gly fusion Deposited 2024-10-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–124（78 aa）
Chain A
47–121（75 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；298 K；0.05 M Ammonium sulfate, 0.05 M BIS-TRIS pH 6.5, Polyethylene glycol 600
|
Resolution 3.58 Å R-free 0.324 |
| 9FEH Crystal structure of SARS-CoV-2 nsp14 methyltransferase domain in complex with the STM957 inhibitor Deposited 2024-05-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–123（77 aa）
|
Not recorded | A1IB6 ~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-pyridin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-3-cyano-~{N}-ethyl-4-methoxy-benzenesulfonamide × 1 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；12.5% w/v PEG 4000, 20% w/v 1,2,6-hexanetriol;
100mM Gly-Gly/AMPD pH 8.5;
10mM spermine, 10mM spermidine, 10mM 1,4-diaminobutane, 10mM DL-ornithine
|
Resolution 1.99 Å R-free 0.230 |
| 9NGE The ubiquitin-associated domain of human thirty-eight negative kinase-1 rigidly fused to a double trigger variant of the 1TEL crystallization chaperone Deposited 2025-02-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–122（76 aa）
|
Mutation：R80S,L96E,V112E in ETV6, and L591V,C610A,C644A in TNK1 (Uniprot numbering) | PEG DI(HYDROXYETHYL)ETHER × 3 K POTASSIUM ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.2M Ammonium citrate tribasic pH 7.0, 20% w/v Polyethylene Glycol 3350
|
Resolution 2.02 Å R-free 0.230 |
| 9NGE The ubiquitin-associated domain of human thirty-eight negative kinase-1 rigidly fused to a double trigger variant of the 1TEL crystallization chaperone Deposited 2025-02-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
47–122（76 aa）
|
Mutation：R80S,L96E,V112E in ETV6, and L591V,C610A,C644A in TNK1 (Uniprot numbering) | K POTASSIUM ION × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.2M Ammonium citrate tribasic pH 7.0, 20% w/v Polyethylene Glycol 3350
|
Resolution 2.02 Å R-free 0.230 |
| 9O0H The ubiquitin-associated domain of human thirty-eight negative kinase 1, fused to the 3TEL crystallization chaperone via a 2-glycine linker Deposited 2025-04-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
47–124（78 aa）
Fragment：TNK1 portion is the ubiquitin-associated domain
Chain B
47–121（75 aa）
Fragment：TNK1 portion is the ubiquitin-associated domain
|
Mutation：V112E (Uniprot numbering) in the first ETV6 repeat, C610A,C644A (Uniprot numbering) in TNK1 Mutation：V112E (Uniprot numbering) in the first ETV6 repeat, C610A,C644A (Uniprot numbering) in TNK1 | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；1.5M Ammonium Chloride, 0.1M BIS-TRISpropane pH 7
|
Resolution 2.24 Å R-free 0.249 |
| 9Q4D A DARPin fused to the double trigger 1TEL variant crystallization chaperone via a direct helical fusion Deposited 2025-08-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–121（75 aa）
|
Mutation：L96E, V112E in ETV6 (Uniprot numbering) | EDO 1,2-ETHANEDIOL × 7 CL CHLORIDE ION × 4 K POTASSIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；0.07M Citric acid, 0.05M BIS-TRIS propane, 16% w/v Polyethylene Glycol 3,350
|
Resolution 1.30 Å R-free 0.185 |
| 9Q9E Crystal structure of a TELSAM-SUMO1 fusion protein Deposited 2025-02-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–123（77 aa）
|
Mutation：V73E | 1PE PENTAETHYLENE GLYCOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Na-phosphate/citric acid pH4.2, PEG600
|
Resolution 2.05 Å R-free 0.231 |
| 9Q9E Crystal structure of a TELSAM-SUMO1 fusion protein Deposited 2025-02-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
47–123（77 aa）
|
Mutation：V73E | PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Na-phosphate/citric acid pH4.2, PEG600
|
Resolution 2.05 Å R-free 0.231 |
| 9Q9E Crystal structure of a TELSAM-SUMO1 fusion protein Deposited 2025-02-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
47–123（77 aa）
|
Mutation：V73E | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Na-phosphate/citric acid pH4.2, PEG600
|
Resolution 2.05 Å R-free 0.231 |
| 9YKB The von Willebrand factor A domain of human capillary morphogenesis gene II, fused to the 1TEL crystallization chaperone, Ala-Val linker variant, expressed with SUMO tag. Deposited 2025-10-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–123（77 aa）
|
Mutation：R4A,V67E,K77A,R81A,A82V,C215A | MG MAGNESIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；0.1 M BisTrisPropane, 1.5M Ammonium Sulfate
|
Resolution 2.50 Å R-free 0.194 |
| 9YKB The von Willebrand factor A domain of human capillary morphogenesis gene II, fused to the 1TEL crystallization chaperone, Ala-Val linker variant, expressed with SUMO tag. Deposited 2025-10-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
47–123（77 aa）
|
Mutation：R4A,V67E,K77A,R81A,A82V,C215A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；0.1 M BisTrisPropane, 1.5M Ammonium Sulfate
|
Resolution 2.50 Å R-free 0.194 |
| 9YKB The von Willebrand factor A domain of human capillary morphogenesis gene II, fused to the 1TEL crystallization chaperone, Ala-Val linker variant, expressed with SUMO tag. Deposited 2025-10-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
47–123（77 aa）
|
Mutation：R4A,V67E,K77A,R81A,A82V,C215A | MG MAGNESIUM ION × 2 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；0.1 M BisTrisPropane, 1.5M Ammonium Sulfate
|
Resolution 2.50 Å R-free 0.194 |
| 9Z2L The ubiquitin-associated domain of human thirty-eight negative kinase-1 rigidly fused to the 1TEL crystallization chaperone Deposited 2025-11-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–122（76 aa）
|
Mutation：R46S,V78E,L90V,C109A,C143A | SO4 SULFATE ION × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；0.6 M Magnesium Sulfate, 0.1 Sodium Acetate
|
Resolution 2.02 Å R-free 0.274 |
| 9Z2L The ubiquitin-associated domain of human thirty-eight negative kinase-1 rigidly fused to the 1TEL crystallization chaperone Deposited 2025-11-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
47–122（76 aa）
|
Mutation：R46S,V78E,L90V,C109A,C143A | CL CHLORIDE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；0.6 M Magnesium Sulfate, 0.1 Sodium Acetate
|
Resolution 2.02 Å R-free 0.274 |
| 9ZB7 A DARPin fused to the 1TEL crystallization chaperone via a direct helical fusion Deposited 2025-11-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–121（75 aa）
|
Mutation：V112E | AKG 2-OXOGLUTARIC ACID × 1 NH4 AMMONIUM ION × 1 GOL GLYCEROL × 2 EOH ETHANOL × 2 K POTASSIUM ION × 5 CL CHLORIDE ION × 5 PO4 PHOSPHATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.2；298 K；0.4 M Ammonium phosphate monobasic
|
Resolution 1.24 Å R-free 0.170 |
| 9ZNB Crystal Structure of a DARPin Fused to the 1TEL Crystallization Chaperone via a Direct Helical Fusion in a 3-Fold Crystal Form Deposited 2025-12-12 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–121（75 aa）
Fragment：residues 47-121 (Uniprot numbering) of the ETV6 portion
|
Mutation：V112E in ETV6 (Uniprot numbering) | ACY ACETIC ACID × 1 CL CHLORIDE ION × 4 MG MAGNESIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.6；294 K；1.0 M Magnesium sulfate hydrate, 0.1 M Sodium acetate trihydrate pH 4.6
|
Resolution 1.77 Å R-free 0.220 |
| 9ZVU The ubiquitin-associated domain of human thirty-eight negative kinase-1 rigidly fused to a double trigger variant of the 1TEL crystallization chaperone, alternate crystal form Deposited 2025-12-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
47–122（76 aa）
Fragment：TNK1 UBA domain,TNK1 UBA domain
|
Mutation：R80S,L96E,V112E,L591V,C610A,C644A | TLA L(+)-TARTARIC ACID × 4 NA SODIUM ION × 4 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；0.2M Sodium Tartrate, 16% PEG 3350 Monodisperse
|
Resolution 1.96 Å R-free 0.247 |
| 9ZVU The ubiquitin-associated domain of human thirty-eight negative kinase-1 rigidly fused to a double trigger variant of the 1TEL crystallization chaperone, alternate crystal form Deposited 2025-12-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
47–122（76 aa）
Fragment：TNK1 UBA domain,TNK1 UBA domain
|
Mutation：R80S,L96E,V112E,L591V,C610A,C644A | TLA L(+)-TARTARIC ACID × 3 NA SODIUM ION × 4 SO4 SULFATE ION × 2 TAR D(-)-TARTARIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；0.2M Sodium Tartrate, 16% PEG 3350 Monodisperse
|
Resolution 1.96 Å R-free 0.247 |
40 other PDB entries and 63 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | ETV6_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–83； UniProt 43–125 Author chain B； PDBConstruct 1–83； UniProt 43–125 |
