GLUTAMATE RECEPTOR 2
RATTUS NORVEGICUS
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein homooligomer Homooligomer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count | Chain A； UniProt 22–847 Chain B； UniProt 22–847 Chain C； UniProt 22–847 Chain D； UniProt 22–847 | Fragment：RESIDUES 22-847 Mutation：YES | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 | ELECTRON MICROSCOPY cryo-EM buffer：150 MM NACL, 20 MM TRIS, 0.75 MM DDM, 0.12 MM CHS, 0.3 MM ZK200775；pH 8；150 MM NACL, 20 MM TRIS, 0.75 MM DDM, 0.12 MM CHS, 0.3 MM ZK200775 cryo-EM vitrification conditions：Cryogen ETHANE；ETHANE | Resolution 10.40 Å |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 4UQJ | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1FTJ CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH GLUTAMATE AT 1.9 RESOLUTION Deposited 2000-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
|
Not recorded | ZN ZINC ION × 1 GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M Cacodylate 15% PEG 8000 0.2 M Zinc Acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 4K
|
Resolution 1.90 Å R-free 0.266 |
| 1FTJ CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH GLUTAMATE AT 1.9 RESOLUTION Deposited 2000-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
|
Not recorded | ZN ZINC ION × 2 GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M Cacodylate 15% PEG 8000 0.2 M Zinc Acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 4K
|
Resolution 1.90 Å R-free 0.266 |
| 1FTJ CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH GLUTAMATE AT 1.9 RESOLUTION Deposited 2000-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
|
Not recorded | ZN ZINC ION × 2 GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M Cacodylate 15% PEG 8000 0.2 M Zinc Acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 4K
|
Resolution 1.90 Å R-free 0.266 |
| 1FTJ CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH GLUTAMATE AT 1.9 RESOLUTION Deposited 2000-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
|
Not recorded | ZN ZINC ION × 5 GLU GLUTAMIC ACID × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M Cacodylate 15% PEG 8000 0.2 M Zinc Acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 4K
|
Resolution 1.90 Å R-free 0.266 |
| 1FTJ CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH GLUTAMATE AT 1.9 RESOLUTION Deposited 2000-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J))
|
Not recorded | ZN ZINC ION × 3 GLU GLUTAMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M Cacodylate 15% PEG 8000 0.2 M Zinc Acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 4K
|
Resolution 1.90 Å R-free 0.266 |
| 1FTK CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2I) IN COMPLEX WITH KAINATE AT 1.6 A RESOLUTION Deposited 2000-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
404–528（125 aa）
Fragment：LIGAND BINDING CORE, S1S2I
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE, S1S2I
|
Not recorded | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15% PEG 8000
50 mM potassium phosphate
, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.60 Å R-free 0.261 |
| 1FTL CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH THE ANTAGONIST DNQX AT 1.8 A RESOLUTION Deposited 2000-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | DNQ 6,7-DINITROQUINOXALINE-2,3-DIONE × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；19% PEG 4000
0.3 M ammonium sulfate
0.1 M sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.80 Å R-free 0.272 |
| 1FTM CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION Deposited 2000-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 1 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15% PEG 8000
0.2 M Zinc Acetate
0.1 M Cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.70 Å R-free 0.247 |
| 1FTM CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION Deposited 2000-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
413–527（115 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 2 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15% PEG 8000
0.2 M Zinc Acetate
0.1 M Cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.70 Å R-free 0.247 |
| 1FTM CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION Deposited 2000-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
413–527（115 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 2 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15% PEG 8000
0.2 M Zinc Acetate
0.1 M Cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.70 Å R-free 0.247 |
| 1FTM CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION Deposited 2000-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 5 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15% PEG 8000
0.2 M Zinc Acetate
0.1 M Cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.70 Å R-free 0.247 |
| 1FTM CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION Deposited 2000-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 3 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15% PEG 8000
0.2 M Zinc Acetate
0.1 M Cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.70 Å R-free 0.247 |
| 1FTO CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN THE APO STATE AT 2.0 A RESOLUTION Deposited 2000-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；22% PEG 8000 0.3 M ammonium sulfate 0.1 M sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.00 Å R-free 0.287 |
| 1FTO CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN THE APO STATE AT 2.0 A RESOLUTION Deposited 2000-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；22% PEG 8000 0.3 M ammonium sulfate 0.1 M sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.00 Å R-free 0.287 |
| 1FW0 CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH KAINATE AT 2.0 A RESOLUTION Deposited 2000-09-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；274 K；10% PEG 1450, 0.1 M sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 274K
|
Resolution 1.90 Å R-free 0.308 |
| 1GR2 STRUCTURE OF A GLUTAMATE RECEPTOR LIGAND BINDING CORE (GLUR2) COMPLEXED WITH KAINATE Deposited 1998-09-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
404–528（125 aa）
Fragment：LIGAND BINDING DOMAIN
Chain A
652–796（145 aa）
Fragment：LIGAND BINDING DOMAIN
|
Not recorded | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；50 MM KIPI, PH 5.0, 14% PEG 8K
|
Resolution 1.90 Å R-free 0.273 |
| 1LB8 Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in complex with AMPA at 2.3 resolution Deposited 2002-04-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Fragment：ligand-binding core (flop)
Chain A
653–796（144 aa）
Fragment：ligand-binding core (flop)
|
Mutation：L483Y Mutation：L483Y | AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；PEG 8000, ammonium sulfate, sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 277.0K
|
Resolution 2.30 Å R-free 0.267 |
| 1LB8 Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in complex with AMPA at 2.3 resolution Deposited 2002-04-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
413–527（115 aa）
Fragment：ligand-binding core (flop)
Chain B
653–796（144 aa）
Fragment：ligand-binding core (flop)
|
Mutation：L483Y Mutation：L483Y | AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；PEG 8000, ammonium sulfate, sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 277.0K
|
Resolution 2.30 Å R-free 0.267 |
| 1LB9 Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in complex with antagonist DNQX at 2.3 A resolution Deposited 2002-04-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Fragment：ligand binding core (flop)
Chain A
653–796（144 aa）
Fragment：ligand binding core (flop)
|
Mutation：L483Y Mutation：L483Y | DNQ 6,7-DINITROQUINOXALINE-2,3-DIONE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；PEG 4000, ammonium sulfate, sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 277.0K
|
Resolution 2.30 Å R-free 0.268 |
| 1LB9 Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in complex with antagonist DNQX at 2.3 A resolution Deposited 2002-04-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
413–527（115 aa）
Fragment：ligand binding core (flop)
Chain B
653–796（144 aa）
Fragment：ligand binding core (flop)
|
Mutation：L483Y Mutation：L483Y | DNQ 6,7-DINITROQUINOXALINE-2,3-DIONE × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；PEG 4000, ammonium sulfate, sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 277.0K
|
Resolution 2.30 Å R-free 0.268 |
| 1LBB Crystal structure of the GluR2 ligand binding domain mutant (S1S2J-N754D) in complex with kainate at 2.1 A resolution Deposited 2002-04-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Fragment：ligand binding core (flop)
Chain A
653–796（144 aa）
Fragment：ligand binding core (flop)
|
Mutation：N754D Mutation：N754D | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；PEG 1000, Li2SO4, phosphate-citrate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.0K
|
Resolution 2.10 Å R-free 0.260 |
| 1M5B X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH 2-Me-Tet-AMPA AT 1.85 A RESOLUTION. Deposited 2002-07-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：flop ligand binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：flop ligand binding core (S1S2J)
Chain C
413–527（115 aa）
Fragment：flop ligand binding core (S1S2J)
Chain C
653–796（144 aa）
Fragment：flop ligand binding core (S1S2J)
|
Not recorded | ZN ZINC ION × 3 BN1 (S)-2-AMINO-3-[3-HYDROXY-5-(2-METHYL-2H-TETRAZOL-5-YL)ISOXAZOL-4-YL]PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.85 Å R-free 0.234 |
| 1M5B X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH 2-Me-Tet-AMPA AT 1.85 A RESOLUTION. Deposited 2002-07-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：flop ligand binding core (S1S2J)
Chain B
653–796（144 aa）
Fragment：flop ligand binding core (S1S2J)
|
Not recorded | ZN ZINC ION × 4 BN1 (S)-2-AMINO-3-[3-HYDROXY-5-(2-METHYL-2H-TETRAZOL-5-YL)ISOXAZOL-4-YL]PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.85 Å R-free 0.234 |
| 1M5B X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH 2-Me-Tet-AMPA AT 1.85 A RESOLUTION. Deposited 2002-07-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：flop ligand binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：flop ligand binding core (S1S2J)
Chain B
413–527（115 aa）
Fragment：flop ligand binding core (S1S2J)
Chain B
653–796（144 aa）
Fragment：flop ligand binding core (S1S2J)
Chain C
413–527（115 aa）
Fragment：flop ligand binding core (S1S2J)
Chain C
653–796（144 aa）
Fragment：flop ligand binding core (S1S2J)
|
Not recorded | ZN ZINC ION × 5 BN1 (S)-2-AMINO-3-[3-HYDROXY-5-(2-METHYL-2H-TETRAZOL-5-YL)ISOXAZOL-4-YL]PROPIONIC ACID × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.85 Å R-free 0.234 |
| 1M5C X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH Br-HIBO AT 1.65 A RESOLUTION Deposited 2002-07-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：flop ligand binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：flop ligand binding core (S1S2J)
|
Not recorded | BRH (S)-2-AMINO-3-(4-BROMO-3-HYDROXY-ISOXAZOL-5-YL)PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；PEG 1450, Li2SO4, phosphate-citrate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.65 Å R-free 0.221 |
| 1M5D X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J-Y702F) IN COMPLEX WITH Br-HIBO AT 1.73 A RESOLUTION Deposited 2002-07-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：flop ligand binding core (S1S2J-Y702F)
Chain A
653–796（144 aa）
Fragment：flop ligand binding core (S1S2J-Y702F)
|
Mutation：Y190F Mutation：Y190F | SO4 SULFATE ION × 4 BRH (S)-2-AMINO-3-(4-BROMO-3-HYDROXY-ISOXAZOL-5-YL)PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；PEG 3350, Li2SO4, phosphate-citrate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.73 Å R-free 0.215 |
| 1M5E X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH ACPA AT 1.46 A RESOLUTION Deposited 2002-07-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：GluR2-flop ligand binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：GluR2-flop ligand binding core (S1S2J)
Chain C
413–527（115 aa）
Fragment：GluR2-flop ligand binding core (S1S2J)
Chain C
653–796（144 aa）
Fragment：GluR2-flop ligand binding core (S1S2J)
|
Not recorded | ZN ZINC ION × 4 AM1 (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.46 Å R-free 0.216 |
| 1M5E X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH ACPA AT 1.46 A RESOLUTION Deposited 2002-07-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：GluR2-flop ligand binding core (S1S2J)
Chain B
653–796（144 aa）
Fragment：GluR2-flop ligand binding core (S1S2J)
|
Not recorded | ZN ZINC ION × 8 AM1 (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID × 2 ACT ACETATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.46 Å R-free 0.216 |
| 1M5E X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH ACPA AT 1.46 A RESOLUTION Deposited 2002-07-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：GluR2-flop ligand binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：GluR2-flop ligand binding core (S1S2J)
Chain B
413–527（115 aa）
Fragment：GluR2-flop ligand binding core (S1S2J)
Chain B
653–796（144 aa）
Fragment：GluR2-flop ligand binding core (S1S2J)
Chain C
413–527（115 aa）
Fragment：GluR2-flop ligand binding core (S1S2J)
Chain C
653–796（144 aa）
Fragment：GluR2-flop ligand binding core (S1S2J)
|
Not recorded | ZN ZINC ION × 8 AM1 (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID × 3 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.46 Å R-free 0.216 |
| 1M5F X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J-Y702F) IN COMPLEX WITH ACPA AT 1.95 A RESOLUTION Deposited 2002-07-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：flop ligand binding core (S1S2J-Y702F)
Chain A
653–796（144 aa）
Fragment：flop ligand binding core (S1S2J-Y702F)
Chain C
413–527（115 aa）
Fragment：flop ligand binding core (S1S2J-Y702F)
Chain C
653–796（144 aa）
Fragment：flop ligand binding core (S1S2J-Y702F)
|
Mutation：Y190F Mutation：Y190F Mutation：Y190F Mutation：Y190F | ZN ZINC ION × 2 AM1 (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.95 Å R-free 0.230 |
| 1M5F X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J-Y702F) IN COMPLEX WITH ACPA AT 1.95 A RESOLUTION Deposited 2002-07-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：flop ligand binding core (S1S2J-Y702F)
Chain B
653–796（144 aa）
Fragment：flop ligand binding core (S1S2J-Y702F)
|
Mutation：Y190F Mutation：Y190F | ZN ZINC ION × 8 AM1 (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID × 2 ACT ACETATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.95 Å R-free 0.230 |
| 1M5F X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J-Y702F) IN COMPLEX WITH ACPA AT 1.95 A RESOLUTION Deposited 2002-07-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：flop ligand binding core (S1S2J-Y702F)
Chain A
653–796（144 aa）
Fragment：flop ligand binding core (S1S2J-Y702F)
Chain B
413–527（115 aa）
Fragment：flop ligand binding core (S1S2J-Y702F)
Chain B
653–796（144 aa）
Fragment：flop ligand binding core (S1S2J-Y702F)
Chain C
413–527（115 aa）
Fragment：flop ligand binding core (S1S2J-Y702F)
Chain C
653–796（144 aa）
Fragment：flop ligand binding core (S1S2J-Y702F)
|
Mutation：Y190F Mutation：Y190F Mutation：Y190F Mutation：Y190F Mutation：Y190F Mutation：Y190F | ZN ZINC ION × 6 AM1 (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID × 3 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.95 Å R-free 0.230 |
| 1MM6 crystal structure of the GluR2 ligand binding core (S1S2J) in complex with quisqualate in a non zinc crystal form at 2.15 angstroms resolution Deposited 2002-09-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | SO4 SULFATE ION × 3 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 8K, ammonium sulfate, sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.15 Å R-free 0.237 |
| 1MM7 Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in a Zinc Crystal Form at 1.65 Angstroms Resolution Deposited 2002-09-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 3 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 8K, zinc acetate, sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.65 Å R-free 0.237 |
| 1MM7 Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in a Zinc Crystal Form at 1.65 Angstroms Resolution Deposited 2002-09-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 4 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 8K, zinc acetate, sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.65 Å R-free 0.237 |
| 1MQD X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate. Deposited 2002-09-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
Chain A
653–794（142 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
|
Not recorded | SO4 SULFATE ION × 2 SHI (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.2；279 K；20% PEG 8000, 0.1M lithium sulfate, 0.1M cacodylate, pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.46 Å R-free 0.192 |
| 1MQD X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate. Deposited 2002-09-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
Chain B
653–794（142 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
|
Not recorded | SO4 SULFATE ION × 2 SHI (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.2；279 K；20% PEG 8000, 0.1M lithium sulfate, 0.1M cacodylate, pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.46 Å R-free 0.192 |
| 1MQD X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate. Deposited 2002-09-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
Chain C
653–794（142 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
|
Not recorded | SHI (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.2；279 K；20% PEG 8000, 0.1M lithium sulfate, 0.1M cacodylate, pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.46 Å R-free 0.192 |
| 1MQD X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate. Deposited 2002-09-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
Chain D
653–794（142 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
|
Not recorded | SO4 SULFATE ION × 2 SHI (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.2；279 K；20% PEG 8000, 0.1M lithium sulfate, 0.1M cacodylate, pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.46 Å R-free 0.192 |
| 1MQG Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Iodo-Willardiine at 2.15 Angstroms Resolution Deposited 2002-09-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain B
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
|
Not recorded | SO4 SULFATE ION × 2 IWD 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.2；277 K；PEG 1000, Phosphate-citrate buffer, Li sulfate, pH 4.2, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.15 Å R-free 0.233 |
| 1MQH Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Bromo-Willardiine at 1.8 Angstroms Resolution Deposited 2002-09-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
|
Not recorded | BWD 2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 8K, ammonium sulfate, Na Acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.80 Å R-free 0.231 |
| 1MQI Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Fluoro-Willardiine at 1.35 Angstroms Resolution Deposited 2002-09-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
|
Not recorded | FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 8K, NaCl, Na Citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.35 Å R-free 0.218 |
| 1MQJ Crystal structure of the GluR2 ligand binding core (S1S2J) in complex with willardiine at 1.65 angstroms resolution Deposited 2002-09-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
|
Not recorded | ZN ZINC ION × 2 HWD 2-AMINO-3-(2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 5K MME, Na Citrate, zinc acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.65 Å R-free 0.229 |
| 1MS7 X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.97 A resolution, Crystallization in the presence of zinc acetate Deposited 2002-09-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
Chain C
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
Chain C
653–796（144 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
|
Not recorded | ZN ZINC ION × 2 SHI (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；17% PEG 8000, 0.05M zinc acetate, 0.1M cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.97 Å R-free 0.213 |
| 1MS7 X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.97 A resolution, Crystallization in the presence of zinc acetate Deposited 2002-09-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
Chain B
653–796（144 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
|
Not recorded | ZN ZINC ION × 8 SHI (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；17% PEG 8000, 0.05M zinc acetate, 0.1M cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.97 Å R-free 0.213 |
| 1MS7 X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.97 A resolution, Crystallization in the presence of zinc acetate Deposited 2002-09-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
Chain B
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
Chain B
653–796（144 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
Chain C
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
Chain C
653–796（144 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
|
Not recorded | ZN ZINC ION × 6 SHI (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；17% PEG 8000, 0.05M zinc acetate, 0.1M cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.97 Å R-free 0.213 |
| 1MXU CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) in complex with bromo-willardiine (Control for the crystal titration experiments) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 3 BWD 2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8K, ammonium sulfate, zinc acetate, BrW and sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.80 Å R-free 0.234 |
| 1MXU CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) in complex with bromo-willardiine (Control for the crystal titration experiments) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 4 BWD 2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8K, ammonium sulfate, zinc acetate, BrW and sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.80 Å R-free 0.234 |
| 1MXU CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) in complex with bromo-willardiine (Control for the crystal titration experiments) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 5 BWD 2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8K, ammonium sulfate, zinc acetate, BrW and sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.80 Å R-free 0.234 |
| 1MXV crystal titration experiments (AMPA co-crystals soaked in 10 mM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.95 Å R-free 0.248 |
| 1MXV crystal titration experiments (AMPA co-crystals soaked in 10 mM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.95 Å R-free 0.248 |
| 1MXV crystal titration experiments (AMPA co-crystals soaked in 10 mM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.95 Å R-free 0.248 |
| 1MXW crystal titration experiments (AMPA co-crystals soaked in 1 mM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.252 |
| 1MXW crystal titration experiments (AMPA co-crystals soaked in 1 mM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.252 |
| 1MXW crystal titration experiments (AMPA co-crystals soaked in 1 mM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.252 |
| 1MXX crystal titration experiments (AMPA co-crystals soaked in 100 uM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.00 Å R-free 0.250 |
| 1MXX crystal titration experiments (AMPA co-crystals soaked in 100 uM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.00 Å R-free 0.250 |
| 1MXX crystal titration experiments (AMPA co-crystals soaked in 100 uM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.00 Å R-free 0.250 |
| 1MXY crystal titration experiments (AMPA co-crystals soaked in 10 uM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.95 Å R-free 0.259 |
| 1MXY crystal titration experiments (AMPA co-crystals soaked in 10 uM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.95 Å R-free 0.259 |
| 1MXY crystal titration experiments (AMPA co-crystals soaked in 10 uM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.95 Å R-free 0.259 |
| 1MXZ crystal titration experiments (AMPA co-crystals soaked in 1 uM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.256 |
| 1MXZ crystal titration experiments (AMPA co-crystals soaked in 1 uM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.256 |
| 1MXZ crystal titration experiments (AMPA co-crystals soaked in 1 uM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.256 |
| 1MY0 crystal titration experiments (AMPA co-crystals soaked in 100 nM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.249 |
| 1MY0 crystal titration experiments (AMPA co-crystals soaked in 100 nM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.249 |
| 1MY0 crystal titration experiments (AMPA co-crystals soaked in 100 nM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.249 |
| 1MY1 crystal titration experiments (AMPA co-crystals soaked in 10 nM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.248 |
| 1MY1 crystal titration experiments (AMPA co-crystals soaked in 10 nM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.248 |
| 1MY1 crystal titration experiments (AMPA co-crystals soaked in 10 nM BrW) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.248 |
| 1MY2 crystal titration experiment (AMPA complex control) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 3 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.80 Å R-free 0.244 |
| 1MY2 crystal titration experiment (AMPA complex control) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 4 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.80 Å R-free 0.244 |
| 1MY2 crystal titration experiment (AMPA complex control) Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 5 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.80 Å R-free 0.244 |
| 1MY3 crystal structure of glutamate receptor ligand-binding core in complex with bromo-willardiine in the Zn crystal form Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 3 BWD 2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, ammonium sulfate, zinc acetate and sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.75 Å R-free 0.255 |
| 1MY3 crystal structure of glutamate receptor ligand-binding core in complex with bromo-willardiine in the Zn crystal form Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 4 BWD 2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, ammonium sulfate, zinc acetate and sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.75 Å R-free 0.255 |
| 1MY4 crystal structure of glutamate receptor ligand-binding core in complex with iodo-willardiine in the Zn crystal form Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 3 IWD 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；PEG4K, ammonium sulfate, zinc acetate and Tris-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.262 |
| 1MY4 crystal structure of glutamate receptor ligand-binding core in complex with iodo-willardiine in the Zn crystal form Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 4 IWD 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；PEG4K, ammonium sulfate, zinc acetate and Tris-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.262 |
| 1MY4 crystal structure of glutamate receptor ligand-binding core in complex with iodo-willardiine in the Zn crystal form Deposited 2002-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 5 IWD 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；PEG4K, ammonium sulfate, zinc acetate and Tris-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.262 |
| 1N0T X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with the antagonist (S)-ATPO at 2.1 A resolution. Deposited 2002-10-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J).
Chain A
653–796（144 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J).
Chain C
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J).
Chain C
653–796（144 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J).
|
Not recorded | AT1 (S)-2-AMINO-3-(5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL)PROPIONIC ACID × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.2；279 K；PEG 3350, AMMONIUM SULFATE, SODIUM ACETATE pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 2.10 Å R-free 0.245 |
| 1N0T X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with the antagonist (S)-ATPO at 2.1 A resolution. Deposited 2002-10-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J).
Chain B
653–796（144 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J).
Chain D
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J).
Chain D
653–796（144 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J).
|
Not recorded | AT1 (S)-2-AMINO-3-(5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL)PROPIONIC ACID × 2 SO4 SULFATE ION × 2 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.2；279 K；PEG 3350, AMMONIUM SULFATE, SODIUM ACETATE pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 2.10 Å R-free 0.245 |
| 1NNK X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.85 A resolution. Crystallization with zinc ions. Deposited 2003-01-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
|
Not recorded | ZN ZINC ION × 4 CL CHLORIDE ION × 2 CE2 3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；zinc acetate, cacodylate, PEG8000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.85 Å R-free 0.245 |
| 1NNP X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions. Deposited 2003-01-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
Chain B
653–796（144 aa）
Fragment：GluR2-flop ligand-binding core (S1S2J)
|
Not recorded | SO4 SULFATE ION × 2 CE2 3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；279 K；ammonium sulfate, PEG8000, sodium acetate, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.90 Å R-free 0.216 |
| 1P1N GluR2 Ligand Binding Core (S1S2J) Mutant L650T in Complex with Kainate Deposited 2003-04-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
|
Mutation：L138T Mutation：L138T | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；PEG 4000, ammonium sulfate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.60 Å R-free 0.252 |
| 1P1O Crystal structure of the GluR2 ligand-binding core (S1S2J) mutant L650T in complex with quisqualate Deposited 2003-04-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
|
Mutation：L138T Mutation：L138T | SO4 SULFATE ION × 4 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；PEG4000, ammonium sulfate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.60 Å R-free 0.235 |
| 1P1Q Crystal structure of the GluR2 ligand binding core (S1S2J) L650T mutant in complex with AMPA Deposited 2003-04-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
Chain C
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain C
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
|
Mutation：L138T Mutation：L138T Mutation：L138T Mutation：L138T | ZN ZINC ION × 3 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, cacodylate, zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.00 Å R-free 0.270 |
| 1P1Q Crystal structure of the GluR2 ligand binding core (S1S2J) L650T mutant in complex with AMPA Deposited 2003-04-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain B
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
|
Mutation：L138T Mutation：L138T | ZN ZINC ION × 4 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, cacodylate, zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.00 Å R-free 0.270 |
| 1P1U Crystal structure of the GluR2 ligand-binding core (S1S2J) L650T mutant in complex with AMPA (ammonium sulfate crystal form) Deposited 2003-04-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
Chain B
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain B
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
|
Mutation：L138T Mutation：L138T Mutation：L138T Mutation：L138T | SO4 SULFATE ION × 1 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；PEG4000, ammonium sulfate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.00 Å R-free 0.271 |
| 1P1W Crystal structure of the GluR2 ligand-binding core (S1S2J) with the L483Y and L650T mutations and in complex with AMPA Deposited 2003-04-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
Chain B
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain B
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
|
Mutation：L94Y,L138T Mutation：L94Y,L138T Mutation：L94Y,L138T Mutation：L94Y,L138T | SO4 SULFATE ION × 2 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；PEG4000, ammonium sulfate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.80 Å R-free 0.264 |
| 1SYH X-RAY STRUCTURE OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 1.85 A RESOLUTION. Deposited 2004-04-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–796（384 aa）
Fragment：GLUR2-FLOP LIGAND-BINDING CORE (S1S2J)
|
Not recorded | CPW (S)-2-AMINO-3-(1,3,5,7-PENTAHYDRO-2,4-DIOXO-CYCLOPENTA[E]PYRIMIDIN-1-YL) PROIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；280 K；PEG8000, cacodylate, (NH4)2SO4 , pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 1.80 Å R-free 0.199 |
| 1SYI X-RAY STRUCTURE OF THE Y702F MUTANT OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 2.1 A RESOLUTION. Deposited 2004-04-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–796（384 aa）
Fragment：GLUR2-FLOP LIGAND-BINDING CORE (S1S2J)
Chain B
413–796（384 aa）
Fragment：GLUR2-FLOP LIGAND-BINDING CORE (S1S2J)
|
Mutation：Y702F Mutation：Y702F | CPW (S)-2-AMINO-3-(1,3,5,7-PENTAHYDRO-2,4-DIOXO-CYCLOPENTA[E]PYRIMIDIN-1-YL) PROIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；280 K；PEG8000, CACODYLATE, (NH4)2SO4, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 2.10 Å R-free 0.254 |
| 1WVJ Exploring the GluR2 ligand-binding core in complex with the bicyclic AMPA analogue (S)-4-AHCP Deposited 2004-12-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–796（144 aa）
|
Not recorded | SO4 SULFATE ION × 4 IBC 3-(3-HYDROXY-7,8-DIHYDRO-6H-CYCLOHEPTA[D]ISOXAZOL-4-YL)-L-ALANINE × 2 GOL GLYCEROL × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；PEG 3350, phosphate-citrate buffer, lithium sulfate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.75 Å R-free 0.214 |
| 1XHY X-ray structure of the Y702F mutant of the GluR2 ligand-binding core (S1S2J) in complex with kainate at 1.85 A resolution Deposited 2004-09-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：GluR2 flop ligand-binding core (S1S2J), UNP residues 413-527 and 653-796
Chain A
653–796（144 aa）
Fragment：GluR2 flop ligand-binding core (S1S2J), UNP residues 413-527 and 653-796
|
Mutation：Y702F Mutation：Y702F | SO4 SULFATE ION × 10 KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；280 K；PEG1000, Li2SO4, cacodylate , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 1.85 Å R-free 0.207 |
| 2AIX X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with (s)-thio-atpa at 2.2 a resolution. Deposited 2005-08-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：GLUR2-FLOP LIGAND-BINDING CORE (S1S2J).
Chain A
653–796（144 aa）
Fragment：GLUR2-FLOP LIGAND-BINDING CORE (S1S2J).
|
Not recorded | U1K (S)-2-AMINO-3-(3-HYDROXY-5-TERT-BUTYLISOTHIAZOL-4-YL) PROPRIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；279 K；SODIUM CHLORIDE, CACODYLATE, PEG 8000, pH 6.50, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 2.17 Å R-free 0.230 |
| 2AL4 CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH quisqualate and CX614. Deposited 2005-08-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
Chain B
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain B
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
Chain F
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain F
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
|
Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. | ZN ZINC ION × 5 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 3 CX6 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；10-14% PEG8000, 0.1-0.15 M Zinc acetate, 0.1 M sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.70 Å R-free 0.223 |
| 2AL4 CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH quisqualate and CX614. Deposited 2005-08-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain C
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain C
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
Chain D
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain D
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
Chain E
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain E
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
|
Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. | ZN ZINC ION × 5 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 3 CX6 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；10-14% PEG8000, 0.1-0.15 M Zinc acetate, 0.1 M sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.70 Å R-free 0.223 |
| 2AL5 Crystal structure of the GluR2 ligand binding core (S1S2J) in complex with fluoro-willardiine and aniracetam Deposited 2005-08-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain A
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
Chain B
413–527（115 aa）
Fragment：ligand binding core (S1S2J)
Chain B
653–796（144 aa）
Fragment：ligand binding core (S1S2J)
|
Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. Mutation：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. | FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 4MP 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；12-14% PEG 8000, 0.25-0.35 M ammonium sulfate and 0.1 M sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.65 Å R-free 0.220 |
| 2ANJ Crystal Structure of the Glur2 Ligand Binding Core (S1S2J-Y450W) Mutant in Complex With the Partial Agonist Kainic Acid at 2.1 A Resolution Deposited 2005-08-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand Binding Core
Chain A
653–796（144 aa）
Fragment：Ligand Binding Core
|
Mutation：Y61W Mutation：Y61W | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；279 K；PEG 8000, Cacodylate, Lithium Sulphate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K, pH 6.50
|
Resolution 2.10 Å R-free 0.248 |
| 2CMO The structure of a mixed glur2 ligand-binding core dimer in complex with (s)-glutamate and the antagonist (s)-ns1209 Deposited 2006-05-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：RESIDUES 413-527,653-796
Chain A
653–796（144 aa）
Fragment：RESIDUES 413-527,653-796
Chain B
413–527（115 aa）
Fragment：RESIDUES 413-527,653-796
Chain B
653–796（144 aa）
Fragment：RESIDUES 413-527,653-796
|
Not recorded | SO4 SULFATE ION × 4 M1L 2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC ACID × 1 GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；pH 6.50
|
Resolution 2.65 Å R-free 0.281 |
| 2GFE Crystal structure of the GluR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution Deposited 2006-03-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–795（143 aa）
Chain C
413–527（115 aa）
Chain C
653–795（143 aa）
|
Mutation：A476E S673D Mutation：A476E S673D Mutation：A476E S673D Mutation：A476E S673D | ZN ZINC ION × 3 GLU GLUTAMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；1 to 1 mixture of: Reservoir: 14% PEG 8K; 0.1M Na Acetate; 0.1 M Zn Acetate.
Protein: 10 mg/ml 0.01 M Na HEPES pH 7.0; 0.02 M NaCl; 0.01 M Na Glutamate; 0.001 M EDTA, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.54 Å R-free 0.227 |
| 2GFE Crystal structure of the GluR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution Deposited 2006-03-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
413–527（115 aa）
Chain B
653–795（143 aa）
|
Mutation：A476E S673D Mutation：A476E S673D | ZN ZINC ION × 2 GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；1 to 1 mixture of: Reservoir: 14% PEG 8K; 0.1M Na Acetate; 0.1 M Zn Acetate.
Protein: 10 mg/ml 0.01 M Na HEPES pH 7.0; 0.02 M NaCl; 0.01 M Na Glutamate; 0.001 M EDTA, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.54 Å R-free 0.227 |
| 2GFE Crystal structure of the GluR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution Deposited 2006-03-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
413–527（115 aa）
Chain A
653–795（143 aa）
Chain B
413–527（115 aa）
Chain B
653–795（143 aa）
Chain C
413–527（115 aa）
Chain C
653–795（143 aa）
|
Mutation：A476E S673D Mutation：A476E S673D Mutation：A476E S673D Mutation：A476E S673D Mutation：A476E S673D Mutation：A476E S673D | ZN ZINC ION × 5 GLU GLUTAMIC ACID × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；1 to 1 mixture of: Reservoir: 14% PEG 8K; 0.1M Na Acetate; 0.1 M Zn Acetate.
Protein: 10 mg/ml 0.01 M Na HEPES pH 7.0; 0.02 M NaCl; 0.01 M Na Glutamate; 0.001 M EDTA, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.54 Å R-free 0.227 |
| 2GFE Crystal structure of the GluR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution Deposited 2006-03-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–795（143 aa）
Chain B
413–527（115 aa）
Chain B
653–795（143 aa）
|
Mutation：A476E S673D Mutation：A476E S673D Mutation：A476E S673D Mutation：A476E S673D | ZN ZINC ION × 3 GLU GLUTAMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；1 to 1 mixture of: Reservoir: 14% PEG 8K; 0.1M Na Acetate; 0.1 M Zn Acetate.
Protein: 10 mg/ml 0.01 M Na HEPES pH 7.0; 0.02 M NaCl; 0.01 M Na Glutamate; 0.001 M EDTA, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.54 Å R-free 0.227 |
| 2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant Deposited 2006-08-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 2 GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50
|
Resolution 2.40 Å R-free 0.281 |
| 2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant Deposited 2006-08-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 3 GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50
|
Resolution 2.40 Å R-free 0.281 |
| 2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant Deposited 2006-08-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 1 GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50
|
Resolution 2.40 Å R-free 0.281 |
| 2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant Deposited 2006-08-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain D
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 1 GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50
|
Resolution 2.40 Å R-free 0.281 |
| 2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant Deposited 2006-08-21 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain D
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain D
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 7 GLU GLUTAMIC ACID × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50
|
Resolution 2.40 Å R-free 0.281 |
| 2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant Deposited 2006-08-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain D
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain D
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 4 GLU GLUTAMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50
|
Resolution 2.40 Å R-free 0.281 |
| 2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant Deposited 2006-08-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 7 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain C
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 3 GLU GLUTAMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50
|
Resolution 2.40 Å R-free 0.281 |
| 2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant Deposited 2006-08-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 8 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain D
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain D
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Not recorded | ZN ZINC ION × 4 GLU GLUTAMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50
|
Resolution 2.40 Å R-free 0.281 |
| 2I3W Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of S729C mutant Deposited 2006-08-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Mutation：G729C Mutation：G729C | GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；0.1 M CITRATE 20% PEG 3000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.30 Å R-free 0.284 |
| 2I3W Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of S729C mutant Deposited 2006-08-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Mutation：G729C Mutation：G729C | GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；0.1 M CITRATE 20% PEG 3000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.30 Å R-free 0.284 |
| 2I3W Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of S729C mutant Deposited 2006-08-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain A
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
Chain B
653–794（142 aa）
Fragment：LIGAND BINDING CORE (S1S2J)
|
Mutation：G729C Mutation：G729C Mutation：G729C Mutation：G729C | GLU GLUTAMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；0.1 M CITRATE 20% PEG 3000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.30 Å R-free 0.284 |
| 2P2A X-ray structure of the GluR2 ligand binding core (S1S2J) in complex with 2-Bn-tet-AMPA at 2.26A resolution Deposited 2007-03-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：GluR2-Flop ligand-binding core (Residues 413-527, 653-796)
Chain A
653–796（144 aa）
Fragment：GluR2-Flop ligand-binding core (Residues 413-527, 653-796)
Chain B
413–527（115 aa）
Fragment：GluR2-Flop ligand-binding core (Residues 413-527, 653-796)
Chain B
653–796（144 aa）
Fragment：GluR2-Flop ligand-binding core (Residues 413-527, 653-796)
|
Not recorded | SO4 SULFATE ION × 3 GLU GLUTAMIC ACID × 1 MP9 2-AMINO-3-[3-HYDROXY-5-(2-BENZYL-2H-5-TETRAZOLYL)-4-ISOXAZOLYL]-PROPIONIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；280 K；PEG4000, Sodium Acetate, Ammonium Sulfate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 2.26 Å R-free 0.273 |
| 2XX7 Crystal structure of 1-(4-(1-pyrrolidinylcarbonyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution. Deposited 2010-11-09 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-795
Chain A
653–795（143 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-795
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-795
Chain C
653–795（143 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-795
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES | GLU GLUTAMIC ACID × 2 1ND 1-[4-(1-PYRROLIDINYLCARBONYL)PHENYL]-3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE × 1 ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.20 Å R-free 0.218 |
| 2XX7 Crystal structure of 1-(4-(1-pyrrolidinylcarbonyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution. Deposited 2010-11-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-795
Chain B
653–795（143 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-795
|
Mutation：YES Mutation：YES | GLU GLUTAMIC ACID × 2 1ND 1-[4-(1-PYRROLIDINYLCARBONYL)PHENYL]-3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE × 2 SO4 SULFATE ION × 2 ZN ZINC ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.20 Å R-free 0.218 |
| 2XX8 Crystal structure of N,N-dimethyl-4-(3-(trifluoromethyl)-4,5,6,7- tetrahydro-1H-indazol-1-yl)benzamide in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution. Deposited 2010-11-09 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES | GLU GLUTAMIC ACID × 2 1NE N,N-DIMETHYL-4-[3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL]BENZAMIDE × 1 ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.55 Å R-free 0.212 |
| 2XX8 Crystal structure of N,N-dimethyl-4-(3-(trifluoromethyl)-4,5,6,7- tetrahydro-1H-indazol-1-yl)benzamide in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution. Deposited 2010-11-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
|
Mutation：YES Mutation：YES | GLU GLUTAMIC ACID × 2 1NE N,N-DIMETHYL-4-[3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL]BENZAMIDE × 2 SO4 SULFATE ION × 2 ZN ZINC ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.55 Å R-free 0.212 |
| 2XX9 Crystal structure of 1-((2-fluoro-4-(3-(trifluoromethyl)-4,5,6,7- tetrahydro-1H-indazol-1-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution. Deposited 2010-11-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
|
Mutation：YES Mutation：YES | GLU GLUTAMIC ACID × 2 1NF N,N-DIMETHYL-4-[3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL]BENZAMIDE × 2 ZN ZINC ION × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.97 Å R-free 0.224 |
| 2XX9 Crystal structure of 1-((2-fluoro-4-(3-(trifluoromethyl)-4,5,6,7- tetrahydro-1H-indazol-1-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution. Deposited 2010-11-09 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES | GLU GLUTAMIC ACID × 2 1NF N,N-DIMETHYL-4-[3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL]BENZAMIDE × 1 SO4 SULFATE ION × 1 ZN ZINC ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.97 Å R-free 0.224 |
| 2XXH Crystal structure of 1-(4-(2-oxo-2-(1-pyrrolidinyl)ethyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.5A resolution. Deposited 2010-11-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
|
Mutation：YES Mutation：YES | GLU GLUTAMIC ACID × 2 1NG 1-{4-[2-OXO-2-(1-PYRROLIDINYL)ETHYL]PHENYL}-3-( TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE × 2 SO4 SULFATE ION × 2 ZN ZINC ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å R-free 0.218 |
| 2XXH Crystal structure of 1-(4-(2-oxo-2-(1-pyrrolidinyl)ethyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.5A resolution. Deposited 2010-11-10 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES | GLU GLUTAMIC ACID × 2 1NG 1-{4-[2-OXO-2-(1-PYRROLIDINYL)ETHYL]PHENYL}-3-( TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE × 1 ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å R-free 0.218 |
| 2XXI Crystal structure of 1-((4-(3-(trifluoromethyl)-6,7-dihydropyrano(4,3- c(pyrazol-1(4H)-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.6A resolution. Deposited 2010-11-10 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain C
413–527（115 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES | GLU GLUTAMIC ACID × 2 JAC 1-({4-[3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO[4,3-C]PYRAZOL-1(4H)-YL]PHENYL}METHYL)-2-PYRROLIDINONE × 1 SO4 SULFATE ION × 1 ZN ZINC ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.60 Å R-free 0.208 |
| 2XXI Crystal structure of 1-((4-(3-(trifluoromethyl)-6,7-dihydropyrano(4,3- c(pyrazol-1(4H)-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.6A resolution. Deposited 2010-11-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796
|
Mutation：YES Mutation：YES | GLU GLUTAMIC ACID × 2 JAC 1-({4-[3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO[4,3-C]PYRAZOL-1(4H)-YL]PHENYL}METHYL)-2-PYRROLIDINONE × 2 ZN ZINC ION × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.60 Å R-free 0.208 |
| 3B6Q Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) Mutant T686A in Complex with Glutamate at 2.0 Resolution Deposited 2007-10-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–796（144 aa）
|
Mutation：T686A Mutation：T686A | SO4 SULFATE ION × 2 GLU GLUTAMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；293 K；0.1 M Tris-HCl, 0.15-0.2 M lithium sulfate, 18-21% PEG4000, pH 8.5, VAPOR DIFFUSION, temperature 293K
|
Resolution 2.00 Å R-free 0.222 |
| 3B6T Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686A Mutant in Complex with Quisqualate at 2.1 Resolution Deposited 2007-10-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–796（144 aa）
|
Mutation：T686A Mutation：T686A | SO4 SULFATE ION × 2 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1 M Tris-HCl, 0.15-0.2 M lithium sulfate, 18-21% PEG4000, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.10 Å R-free 0.274 |
| 3B6W Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686S Mutant in Complex with Glutamate at 1.7 Resolution Deposited 2007-10-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–796（144 aa）
Chain C
413–527（115 aa）
Chain C
653–796（144 aa）
|
Mutation：T686S Mutation：T686S Mutation：T686S Mutation：T686S | SO4 SULFATE ION × 3 GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1 M Tris-HCl, 0.15-0.2 M lithium sulfate, 18-21% PEG4000, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.70 Å R-free 0.260 |
| 3B6W Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686S Mutant in Complex with Glutamate at 1.7 Resolution Deposited 2007-10-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Chain B
653–796（144 aa）
Chain D
413–527（115 aa）
Chain D
653–796（144 aa）
|
Mutation：T686S Mutation：T686S Mutation：T686S Mutation：T686S | SO4 SULFATE ION × 1 GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1 M Tris-HCl, 0.15-0.2 M lithium sulfate, 18-21% PEG4000, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.70 Å R-free 0.260 |
| 3B7D Crystal structure of the GLUR2 ligand binding core (HS1S2J) in complex with CNQX at 2.5 A resolution Deposited 2007-10-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–794（142 aa）
Chain B
413–527（115 aa）
Chain B
653–794（142 aa）
|
Not recorded | CNI 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；40 mM Sodium citrate, 10 mM Ammonium sulfate, 1% PEG 400, pH 6.5, VAPOR DIFFUSION, HANGING DROP
|
Resolution 2.50 Å R-free 0.283 |
| 3B7D Crystal structure of the GLUR2 ligand binding core (HS1S2J) in complex with CNQX at 2.5 A resolution Deposited 2007-10-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
413–527（115 aa）
Chain C
653–794（142 aa）
Chain D
413–527（115 aa）
Chain D
653–794（142 aa）
|
Not recorded | CNI 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；40 mM Sodium citrate, 10 mM Ammonium sulfate, 1% PEG 400, pH 6.5, VAPOR DIFFUSION, HANGING DROP
|
Resolution 2.50 Å R-free 0.283 |
| 3B7D Crystal structure of the GLUR2 ligand binding core (HS1S2J) in complex with CNQX at 2.5 A resolution Deposited 2007-10-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
413–527（115 aa）
Chain E
653–794（142 aa）
Chain F
413–527（115 aa）
Chain F
653–794（142 aa）
|
Not recorded | CNI 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；40 mM Sodium citrate, 10 mM Ammonium sulfate, 1% PEG 400, pH 6.5, VAPOR DIFFUSION, HANGING DROP
|
Resolution 2.50 Å R-free 0.283 |
| 3B7D Crystal structure of the GLUR2 ligand binding core (HS1S2J) in complex with CNQX at 2.5 A resolution Deposited 2007-10-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
413–527（115 aa）
Chain G
653–794（142 aa）
Chain H
413–527（115 aa）
Chain H
653–794（142 aa）
|
Not recorded | CNI 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；40 mM Sodium citrate, 10 mM Ammonium sulfate, 1% PEG 400, pH 6.5, VAPOR DIFFUSION, HANGING DROP
|
Resolution 2.50 Å R-free 0.283 |
| 3BBR Crystal structure of the iGluR2 ligand binding core (S1S2J-N775S) in complex with a dimeric positive modulator as well as glutamate at 2.25 A resolution Deposited 2007-11-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding core
Chain A
653–796（144 aa）
Fragment：Ligand binding core
Chain B
413–527（115 aa）
Fragment：Ligand binding core
Chain B
653–796（144 aa）
Fragment：Ligand binding core
|
Mutation：N775S Mutation：N775S Mutation：N775S Mutation：N775S | SO4 SULFATE ION × 5 CL CHLORIDE ION × 1 GLU GLUTAMIC ACID × 2 BHY N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamide × 1 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；280 K；0.3M ammonium sulfate, 0.1M sodium acetate, 25% PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 2.25 Å R-free 0.231 |
| 3BFT Structure of the ligand-binding core of GluR2 in complex with the agonist (S)-TDPA at 2.25 A resolution Deposited 2007-11-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：residues 1-263
Chain A
653–796（144 aa）
Fragment：residues 1-263
Chain C
413–527（115 aa）
Fragment：residues 1-263
Chain C
653–796（144 aa）
Fragment：residues 1-263
|
Not recorded | S2P (2S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid × 2 ZN ZINC ION × 2 NA SODIUM ION × 1 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 2000, cacodylate, zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 2.27 Å R-free 0.250 |
| 3BFT Structure of the ligand-binding core of GluR2 in complex with the agonist (S)-TDPA at 2.25 A resolution Deposited 2007-11-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：residues 1-263
Chain B
653–796（144 aa）
Fragment：residues 1-263
|
Not recorded | S2P (2S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid × 2 ZN ZINC ION × 6 NA SODIUM ION × 2 CAC CACODYLATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 2000, cacodylate, zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 2.27 Å R-free 0.250 |
| 3BFU Structure of the ligand-binding core of GluR2 in complex with the agonist (R)-TDPA at 1.95 A resolution Deposited 2007-11-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：residues 1-263
Chain A
653–796（144 aa）
Fragment：residues 1-263
|
Not recorded | R2P (2R)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 2000, cacodylate, ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.95 Å R-free 0.233 |
| 3BFU Structure of the ligand-binding core of GluR2 in complex with the agonist (R)-TDPA at 1.95 A resolution Deposited 2007-11-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：residues 1-263
Chain B
653–796（144 aa）
Fragment：residues 1-263
|
Not recorded | R2P (2R)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 2000, cacodylate, ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.95 Å R-free 0.233 |
| 3BFU Structure of the ligand-binding core of GluR2 in complex with the agonist (R)-TDPA at 1.95 A resolution Deposited 2007-11-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
413–527（115 aa）
Fragment：residues 1-263
Chain C
653–796（144 aa）
Fragment：residues 1-263
|
Not recorded | R2P (2R)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 2000, cacodylate, ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.95 Å R-free 0.233 |
| 3BFU Structure of the ligand-binding core of GluR2 in complex with the agonist (R)-TDPA at 1.95 A resolution Deposited 2007-11-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
413–527（115 aa）
Fragment：residues 1-263
Chain D
653–796（144 aa）
Fragment：residues 1-263
|
Not recorded | R2P (2R)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 2000, cacodylate, ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.95 Å R-free 0.233 |
| 3BKI Crystal Structure of the GluR2 ligand binding core (S1S2J) in complex with FQX at 1.87 Angstroms Deposited 2007-12-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain P
413–527（115 aa）
Chain P
653–796（144 aa）
|
Not recorded | FQX [1,2,5]oxadiazolo[3,4-g]quinoxaline-6,7(5H,8H)-dione 1-oxide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP
|
Resolution 1.87 Å R-free 0.221 |
| 3BKI Crystal Structure of the GluR2 ligand binding core (S1S2J) in complex with FQX at 1.87 Angstroms Deposited 2007-12-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
413–527（115 aa）
Chain B
653–796（144 aa）
|
Not recorded | FQX [1,2,5]oxadiazolo[3,4-g]quinoxaline-6,7(5H,8H)-dione 1-oxide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP
|
Resolution 1.87 Å R-free 0.221 |
| 3BKI Crystal Structure of the GluR2 ligand binding core (S1S2J) in complex with FQX at 1.87 Angstroms Deposited 2007-12-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
413–527（115 aa）
Chain C
653–796（144 aa）
|
Not recorded | FQX [1,2,5]oxadiazolo[3,4-g]quinoxaline-6,7(5H,8H)-dione 1-oxide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP
|
Resolution 1.87 Å R-free 0.221 |
| 3BKI Crystal Structure of the GluR2 ligand binding core (S1S2J) in complex with FQX at 1.87 Angstroms Deposited 2007-12-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
413–527（115 aa）
Chain D
653–796（144 aa）
|
Not recorded | FQX [1,2,5]oxadiazolo[3,4-g]quinoxaline-6,7(5H,8H)-dione 1-oxide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP
|
Resolution 1.87 Å R-free 0.221 |
| 3DP6 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to glutamate Deposited 2008-07-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Fragment：S1S2 binding domain
Chain A
653–796（144 aa）
Fragment：S1S2 binding domain
|
Not recorded | ZN ZINC ION × 2 GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；277 K；14-17% PEG 8000, 0.1-0.2 M Zn acetate, 0.1 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50
|
Resolution 1.55 Å R-free 0.244 |
| 3DP6 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to glutamate Deposited 2008-07-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
413–527（115 aa）
Fragment：S1S2 binding domain
Chain B
653–796（144 aa）
Fragment：S1S2 binding domain
|
Not recorded | ZN ZINC ION × 2 GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；277 K；14-17% PEG 8000, 0.1-0.2 M Zn acetate, 0.1 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50
|
Resolution 1.55 Å R-free 0.244 |
| 3DP6 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to glutamate Deposited 2008-07-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
413–527（115 aa）
Fragment：S1S2 binding domain
Chain C
653–796（144 aa）
Fragment：S1S2 binding domain
|
Not recorded | ZN ZINC ION × 2 GLU GLUTAMIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；277 K；14-17% PEG 8000, 0.1-0.2 M Zn acetate, 0.1 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50
|
Resolution 1.55 Å R-free 0.244 |
| 3H03 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to UBP277 Deposited 2009-04-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain A
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
Chain B
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain B
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | UBP 3-[3-(2-carboxyethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-L-alanine × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-16% PEG8K, 0.1-0.15 M Zn acetate, 0.25 M ammonium sulfate, 0.1 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.258 |
| 3H03 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to UBP277 Deposited 2009-04-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain D
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
Chain G
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain G
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | UBP 3-[3-(2-carboxyethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-L-alanine × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-16% PEG8K, 0.1-0.15 M Zn acetate, 0.25 M ammonium sulfate, 0.1 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.258 |
| 3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 Deposited 2009-04-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain G
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain G
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.295 |
| 3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 Deposited 2009-04-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 10 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain E
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
Chain P
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain P
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.295 |
| 3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 Deposited 2009-04-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 11 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain G
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
Chain J
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain J
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.295 |
| 3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 Deposited 2009-04-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 12 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain H
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain H
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
Chain L
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain L
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.295 |
| 3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 Deposited 2009-04-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain B
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.295 |
| 3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 Deposited 2009-04-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain E
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain E
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.295 |
| 3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 Deposited 2009-04-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain H
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain H
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.295 |
| 3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 Deposited 2009-04-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain J
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain J
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.295 |
| 3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 Deposited 2009-04-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain L
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain L
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.295 |
| 3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 Deposited 2009-04-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 7 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain N
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain N
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.295 |
| 3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 Deposited 2009-04-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 8 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain P
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain P
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.295 |
| 3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 Deposited 2009-04-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 9 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain B
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
Chain N
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain N
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.295 |
| 3H5V Crystal structure of the GluR2-ATD Deposited 2009-04-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
0–383（384 aa）
Fragment：UNP residues 21-404
Chain B
0–383（384 aa）
Fragment：UNP residues 21-404
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；14-16% PEG3350, 100mM TrisHCl, 10mM MgCl2, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.33 Å R-free 0.235 |
| 3H5V Crystal structure of the GluR2-ATD Deposited 2009-04-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
0–383（384 aa）
Fragment：UNP residues 21-404
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；14-16% PEG3350, 100mM TrisHCl, 10mM MgCl2, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.33 Å R-free 0.235 |
| 3H5W Crystal structure of the GluR2-ATD in space group P212121 without solvent Deposited 2009-04-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
0–383（384 aa）
Fragment：UNP residues 21-404
Chain B
0–383（384 aa）
Fragment：UNP residues 21-404
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；20% PEG3000, 100mM tri-sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.69 Å R-free 0.291 |
| 3H6T Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and cyclothiazide at 2.25 A resolution Deposited 2009-04-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
Chain A
653–796（144 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
Chain C
413–527（115 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
Chain C
653–796（144 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
|
Mutation：N754S Mutation：N754S Mutation：N754S Mutation：N754S | GLU GLUTAMIC ACID × 2 CYZ CYCLOTHIAZIDE × 2 ZN ZINC ION × 5 GOL GLYCEROL × 6 ACT ACETATE ION × 2 DMS DIMETHYL SULFOXIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；279 K；25 % PEG 4000, 0.3 M Zinc acetate, 0.1 M Cacodylate pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 2.25 Å R-free 0.228 |
| 3H6T Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and cyclothiazide at 2.25 A resolution Deposited 2009-04-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
Chain B
653–796（144 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
|
Mutation：N754S Mutation：N754S | GLU GLUTAMIC ACID × 2 CYZ CYCLOTHIAZIDE × 2 ZN ZINC ION × 10 GOL GLYCEROL × 6 CAC CACODYLATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；279 K；25 % PEG 4000, 0.3 M Zinc acetate, 0.1 M Cacodylate pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 2.25 Å R-free 0.228 |
| 3H6U Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS1493 at 1.85 A resolution Deposited 2009-04-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
Chain A
653–796（144 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
|
Mutation：N754S Mutation：N754S | GLU GLUTAMIC ACID × 2 NS3 (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2 SO4 SULFATE ION × 12 GOL GLYCEROL × 4 FLC CITRATE ANION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.5；279 K；25 % PEG 8000, 0.1 M Lithium sulfate, 0.1 M Phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.85 Å R-free 0.215 |
| 3H6V Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5206 at 2.10 A resolution Deposited 2009-04-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
Chain A
653–796（144 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
Chain B
413–527（115 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
Chain B
653–796（144 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
|
Mutation：N754S Mutation：N754S Mutation：N754S Mutation：N754S | GLU GLUTAMIC ACID × 2 NS6 (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide × 2 GOL GLYCEROL × 2 SO4 SULFATE ION × 7 DMS DIMETHYL SULFOXIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.5；279 K；20 % PEG 4000, 0.3 M Lithium sulfate, 0.1 M Phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 2.10 Å R-free 0.228 |
| 3H6W Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5217 at 1.50 A resolution Deposited 2009-04-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
Chain A
653–796（144 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
|
Mutation：N754S Mutation：N754S | GLU GLUTAMIC ACID × 2 NS7 (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide × 2 SO4 SULFATE ION × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；20 % PEG 4000, 0.1 M Ammonium sulfate, 0.1 M Cacodylate pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.49 Å R-free 0.232 |
| 3H6W Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5217 at 1.50 A resolution Deposited 2009-04-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
Chain B
653–796（144 aa）
Fragment：iGluR2-flop ligand-binding core: UNP residues 413-796
|
Mutation：N754S Mutation：N754S | GLU GLUTAMIC ACID × 2 NS7 (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide × 2 SO4 SULFATE ION × 2 DMS DIMETHYL SULFOXIDE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；20 % PEG 4000, 0.1 M Ammonium sulfate, 0.1 M Cacodylate pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.49 Å R-free 0.232 |
| 3HSY High resolution structure of a dimeric GluR2 N-terminal domain (NTD) Deposited 2009-06-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
25–400（376 aa）
Fragment：N-terminal Domain, UNP residues 25-400
Chain B
25–400（376 aa）
Fragment：N-terminal Domain, UNP residues 25-400
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 SO4 SULFATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.8；293 K；200mM ammonium phosphatre, 20% PEG3350, pH4.8, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 1.75 Å R-free 0.205 |
| 3IJO Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, althiazide Deposited 2009-08-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
414–527（114 aa）
Chain B
653–794（142 aa）
Chain E
414–527（114 aa）
Chain E
653–794（142 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 B4D (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide × 2 ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.00 Å R-free 0.234 |
| 3IJO Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, althiazide Deposited 2009-08-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain H
414–527（114 aa）
Chain H
653–794（142 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 B4D (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.00 Å R-free 0.234 |
| 3IJX Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydrochlorothiazide Deposited 2009-08-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
414–527（114 aa）
Chain B
653–794（142 aa）
Chain D
414–527（114 aa）
Chain D
653–794（142 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 HCZ 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.88 Å R-free 0.257 |
| 3IJX Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydrochlorothiazide Deposited 2009-08-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain H
414–527（114 aa）
Chain H
653–794（142 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 HCZ 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide × 2 ZN ZINC ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.88 Å R-free 0.257 |
| 3IK6 Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, chlorothiazide Deposited 2009-08-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain B
414–527（114 aa）
Fragment：S1S2 binding domain
Chain B
653–794（142 aa）
Fragment：S1S2 binding domain
Chain E
414–527（114 aa）
Fragment：S1S2 binding domain
Chain E
653–794（142 aa）
Fragment：S1S2 binding domain
Chain H
414–527（114 aa）
Fragment：S1S2 binding domain
Chain H
653–794（142 aa）
Fragment：S1S2 binding domain
|
Not recorded | GLU GLUTAMIC ACID × 3 HCZ 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide × 3 ZN ZINC ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.10 Å R-free 0.245 |
| 3IL1 Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, IDRA-21 Deposited 2009-08-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
414–527（114 aa）
Fragment：S1S2 binding domain
Chain B
653–794（142 aa）
Fragment：S1S2 binding domain
Chain E
414–527（114 aa）
Fragment：S1S2 binding domain
Chain E
653–794（142 aa）
Fragment：S1S2 binding domain
|
Mutation：N242S Mutation：N242S Mutation：N242S Mutation：N242S | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 3 B5D (3S)-7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.00 Å R-free 0.234 |
| 3IL1 Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, IDRA-21 Deposited 2009-08-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain H
414–527（114 aa）
Fragment：S1S2 binding domain
Chain H
653–794（142 aa）
Fragment：S1S2 binding domain
|
Mutation：N242S Mutation：N242S | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 4 B5D (3S)-7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.00 Å R-free 0.234 |
| 3ILT Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, trichlormethiazide Deposited 2009-08-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain B
414–527（114 aa）
Fragment：S1S2 binding domain
Chain B
653–794（142 aa）
Fragment：S1S2 binding domain
Chain E
414–527（114 aa）
Fragment：S1S2 binding domain
Chain E
653–794（142 aa）
Fragment：S1S2 binding domain
Chain H
414–527（114 aa）
Fragment：S1S2 binding domain
Chain H
653–794（142 aa）
Fragment：S1S2 binding domain
|
Mutation：N242S Mutation：N242S Mutation：N242S Mutation：N242S Mutation：N242S Mutation：N242S | GLU GLUTAMIC ACID × 3 ZN ZINC ION × 5 TRU 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.11 Å R-free 0.261 |
| 3ILU Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydroflumethiazide Deposited 2009-08-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
414–527（114 aa）
Fragment：S1S2 binding domain
Chain B
653–794（142 aa）
Fragment：S1S2 binding domain
Chain E
414–527（114 aa）
Fragment：S1S2 binding domain
Chain E
653–794（142 aa）
Fragment：S1S2 binding domain
|
Mutation：N242S Mutation：N242S Mutation：N242S Mutation：N242S | GLU GLUTAMIC ACID × 2 HFZ 6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.00 Å R-free 0.226 |
| 3ILU Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydroflumethiazide Deposited 2009-08-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain H
414–527（114 aa）
Fragment：S1S2 binding domain
Chain H
653–794（142 aa）
Fragment：S1S2 binding domain
|
Mutation：N242S Mutation：N242S | GLU GLUTAMIC ACID × 2 HFZ 6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.00 Å R-free 0.226 |
| 3KG2 AMPA subtype ionotropic glutamate receptor in complex with competitive antagonist ZK 200775 Deposited 2009-10-28 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Fragment：sequence database residues 25-847
Chain B
25–847（823 aa）
Fragment：sequence database residues 25-847
Chain C
25–847（823 aa）
Fragment：sequence database residues 25-847
Chain D
25–847（823 aa）
Fragment：sequence database residues 25-847
|
Mutation：N241E, N385D, N392Q, K410A, E413A, M414A, E416A, and C589A Mutation：N241E, N385D, N392Q, K410A, E413A, M414A, E416A, and C589A Mutation：N241E, N385D, N392Q, K410A, E413A, M414A, E416A, and C589A Mutation：N241E, N385D, N392Q, K410A, E413A, M414A, E416A, and C589A | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
277 K；Under paraffin oil, temperature 277K
|
Resolution 3.60 Å R-free 0.296 |
| 3KGC Isolated ligand binding domain dimer of GluA2 ionotropic glutamate receptor in complex with glutamate, LY 404187 and ZK 200775 Deposited 2009-10-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
414–527（114 aa）
Fragment：extracellular domains residues 414-527 and 653-795
Chain A
654–795（142 aa）
Fragment：extracellular domains residues 414-527 and 653-795
Chain B
414–527（114 aa）
Fragment：extracellular domains residues 414-527 and 653-795
Chain B
654–795（142 aa）
Fragment：extracellular domains residues 414-527 and 653-795
|
Not recorded | GLU GLUTAMIC ACID × 1 SO4 SULFATE ION × 2 LY7 N-[(2S)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide × 1 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；19% PEG 4000, 0.3 M ammonium sulfate, 0.1 M sodium acetate, pH 5.0, vapor diffusion, hanging drop, temperature 277K
|
Resolution 1.55 Å R-free 0.224 |
| 3LSF Piracetam bound to the ligand binding domain of GluA2 Deposited 2010-02-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
414–527（114 aa）
Chain B
653–794（142 aa）
Chain E
414–527（114 aa）
Chain E
653–794（142 aa）
|
Mutation：N242S Mutation：N242S Mutation：N242S Mutation：N242S | GLU GLUTAMIC ACID × 2 PZI 2-(2-oxopyrrolidin-1-yl)acetamide × 4 ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18% PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 M zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.85 Å R-free 0.228 |
| 3LSF Piracetam bound to the ligand binding domain of GluA2 Deposited 2010-02-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain H
414–527（114 aa）
Chain H
653–794（142 aa）
|
Mutation：N242S Mutation：N242S | GLU GLUTAMIC ACID × 2 PZI 2-(2-oxopyrrolidin-1-yl)acetamide × 4 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18% PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 M zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.85 Å R-free 0.228 |
| 3LSL Piracetam bound to the ligand binding domain of GluA2 (flop form) Deposited 2010-02-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
414–527（114 aa）
Chain A
653–794（142 aa）
Chain D
414–527（114 aa）
Chain D
653–794（142 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 PZI 2-(2-oxopyrrolidin-1-yl)acetamide × 6 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18% PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 M zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.12 Å R-free 0.263 |
| 3LSL Piracetam bound to the ligand binding domain of GluA2 (flop form) Deposited 2010-02-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
414–527（114 aa）
Chain G
653–794（142 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 PZI 2-(2-oxopyrrolidin-1-yl)acetamide × 6 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18% PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 M zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.12 Å R-free 0.263 |
| 3M3L PEPA bound to the ligand binding domain of GluA2 (flop form) Deposited 2010-03-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain A
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
Chain D
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain D
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | GLU GLUTAMIC ACID × 2 P99 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}sulfanyl)phenoxy]acetamide × 1 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG 8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.85 Å R-free 0.242 |
| 3M3L PEPA bound to the ligand binding domain of GluA2 (flop form) Deposited 2010-03-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
414–527（114 aa）
Fragment：UNP residues 414-527, 652-794
Chain G
653–794（142 aa）
Fragment：UNP residues 414-527, 652-794
|
Not recorded | GLU GLUTAMIC ACID × 2 P99 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}sulfanyl)phenoxy]acetamide × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG 8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.85 Å R-free 0.242 |
| 3N6V Structure of the GluA2 NTD-dimer interface mutant, T78A Deposited 2010-05-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
27–400（374 aa）
Fragment：N-terminal domain
Chain B
27–400（374 aa）
Fragment：N-terminal domain
|
Mutation：T78A Mutation：T78A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；100mM Tris, 200mM MgCl2, 20% PEG 8000, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 3.20 Å R-free 0.265 |
| 3N6V Structure of the GluA2 NTD-dimer interface mutant, T78A Deposited 2010-05-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
27–400（374 aa）
Fragment：N-terminal domain
Chain D
27–400（374 aa）
Fragment：N-terminal domain
|
Mutation：T78A Mutation：T78A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；100mM Tris, 200mM MgCl2, 20% PEG 8000, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 3.20 Å R-free 0.265 |
| 3N6V Structure of the GluA2 NTD-dimer interface mutant, T78A Deposited 2010-05-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
27–400（374 aa）
Fragment：N-terminal domain
Chain F
27–400（374 aa）
Fragment：N-terminal domain
|
Mutation：T78A Mutation：T78A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；100mM Tris, 200mM MgCl2, 20% PEG 8000, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 3.20 Å R-free 0.265 |
| 3O28 Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Deposited 2010-07-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain, UNP residues 413 to 527 and 653 to 796
Chain A
653–795（143 aa）
Fragment：Ligand binding domain, UNP residues 413 to 527 and 653 to 796
|
Not recorded | O28 2-({[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide × 2 GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 6 DMS DIMETHYL SULFOXIDE × 2 GOL GLYCEROL × 12 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；277 K；16% PEG 8000, 100mM Sodium Cacodylate pH 4.5, 50mM Lithium Sulphate, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.00 Å R-free 0.234 |
| 3O29 Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Deposited 2010-07-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain, UNP residues 413 to 527 and 653 to 796
Chain A
653–795（143 aa）
Fragment：Ligand binding domain, UNP residues 413 to 527 and 653 to 796
|
Not recorded | GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 4 GOL GLYCEROL × 8 O29 N-[2-(dimethylamino)ethyl]-2-({[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；277 K；12% PEG 4000, 100mM Sodium Cacodylate pH 4.5, 50mM Lithium Sulphate, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.02 Å R-free 0.250 |
| 3O2A Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Deposited 2010-07-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain, UNP residues 413 to 527 and 653 to 796
Chain A
653–795（143 aa）
Fragment：Ligand binding domain, UNP residues 413 to 527 and 653 to 796
|
Not recorded | O30 N-(3-aminopropyl)-2-({[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide × 2 GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 4 GOL GLYCEROL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；277 K；18% PEG 4000, 100mM Sodium Cacodylate pH 4.5, 50mM Lithium Sulphate, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.217 |
| 3O2J Structure of the GluA2 NTD-dimer interface mutant, N54A Deposited 2010-07-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
22–400（379 aa）
Fragment：N-terminal domain
Chain B
22–400（379 aa）
Fragment：N-terminal domain
|
Mutation：N54A Mutation：N54A | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；291 K；18% PEG 3350, 100mM sodium citrate, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 1.95 Å R-free 0.247 |
| 3O6G Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Deposited 2010-07-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain, UNP residues 413 to 527 and 653 to 796
Chain A
653–795（143 aa）
Fragment：Ligand binding domain, UNP residues 413 to 527 and 653 to 796
|
Not recorded | GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 6 O27 N-[(3R)-pyrrolidin-3-yl]-2-({[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide × 2 EDO 1,2-ETHANEDIOL × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；17% PEG 4000, 100mM Sodium Cacodylate pH 4.0, 50mM Lithium Sulphate, 2.5% Glycerol, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.80 Å R-free 0.223 |
| 3O6H Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Deposited 2010-07-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain, UNP residues 413 to 527 and 653 to 796
Chain A
653–795（143 aa）
Fragment：Ligand binding domain, UNP residues 413 to 527 and 653 to 796
|
Not recorded | GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 6 O25 2-[({4-[(ethylamino)methyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}acetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide × 2 DMS DIMETHYL SULFOXIDE × 2 EDO 1,2-ETHANEDIOL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；18% PEG 4000, 100mM Sodium Cacodylate pH 4.0, 50mM Lithium Sulphate, 5% Glycerol, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.10 Å R-free 0.263 |
| 3O6I Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Deposited 2010-07-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain, UNP residues 413 to 527 and 653 to 796
Chain A
653–795（143 aa）
Fragment：Ligand binding domain, UNP residues 413 to 527 and 653 to 796
|
Not recorded | GLU GLUTAMIC ACID × 2 O26 2-[({3-tert-butyl-4-[(methylamino)methyl]-1H-pyrazol-1-yl}acetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide × 2 SO4 SULFATE ION × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.3；277 K；18% PEG 4000, 50mM Lithium sulphate, 2.5% Glycerol, 100mM Sodium Cacodylate pH 4.3, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.80 Å R-free 0.247 |
| 3PD8 X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution Deposited 2010-10-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：UNP residues 413-527, 653-795
Chain A
653–795（143 aa）
Fragment：UNP residues 413-527, 653-795
Chain B
413–527（115 aa）
Fragment：UNP residues 413-527, 653-795
Chain B
653–795（143 aa）
Fragment：UNP residues 413-527, 653-795
|
Not recorded | ZN ZINC ION × 3 HA7 (7S)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-7-carboxylic acid × 2 GOL GLYCEROL × 1 ACY ACETIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；280 K；PEG4000, zinc acetate, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 2.48 Å R-free 0.261 |
| 3PD8 X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution Deposited 2010-10-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
413–527（115 aa）
Fragment：UNP residues 413-527, 653-795
Chain C
653–795（143 aa）
Fragment：UNP residues 413-527, 653-795
|
Not recorded | ZN ZINC ION × 4 HA7 (7S)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-7-carboxylic acid × 2 CAC CACODYLATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；280 K；PEG4000, zinc acetate, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 2.48 Å R-free 0.261 |
| 3PD9 X-ray structure of the ligand-binding core of GluA2 in complex with (R)-5-HPCA at 2.1 A resolution Deposited 2010-10-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：UNP residues 413-527, 653-795
Chain A
653–795（143 aa）
Fragment：UNP residues 413-527, 653-795
Chain B
413–527（115 aa）
Fragment：UNP residues 413-527, 653-795
Chain B
653–795（143 aa）
Fragment：UNP residues 413-527, 653-795
|
Not recorded | HA5 (5R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid × 2 SO4 SULFATE ION × 4 GOL GLYCEROL × 5 CL CHLORIDE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；280 K；PEG4000, ammonium sulfate, acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 2.10 Å R-free 0.233 |
| 3PMV Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Deposited 2010-11-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain, residues 413 to 527 and 653 to 796
Chain A
653–796（144 aa）
Fragment：Ligand binding domain, residues 413 to 527 and 653 to 796
|
Not recorded | GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 10 557 N-[(2S)-2-{4-[4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}propyl]propane-2-sulfonamide × 2 GOL GLYCEROL × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；18% PEG 4000, 50mM Lithium Sulphate, 2.5% Glycerol, 100mM Sodium Cacodylate pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.80 Å R-free 0.252 |
| 3PMW Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Deposited 2010-11-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain, residues 413 to 527 and 653 to 796
Chain A
653–796（144 aa）
Fragment：Ligand binding domain, residues 413 to 527 and 653 to 796
|
Mutation：S1-S2 fusion in which Gly118 and Thr119 replace a membrane-spanning region Mutation：S1-S2 fusion in which Gly118 and Thr119 replace a membrane-spanning region | GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 14 GOL GLYCEROL × 4 DMS DIMETHYL SULFOXIDE × 2 G69 N-[(2S)-5-{[4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2,3-dihydro-1H-inden-2-yl]propane-2-sulfonami de × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；18% PEG 4000, 50mM Lithium Sulphate, 2.5% Glycerol, 100mM Sodium Cacodylate pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.20 Å R-free 0.313 |
| 3PMX Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Deposited 2010-11-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain, residues 413 to 527 and 653 to 796
Chain A
653–796（144 aa）
Fragment：Ligand binding domain, residues 413 to 527 and 653 to 796
|
Not recorded | GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 8 GOL GLYCEROL × 4 DMS DIMETHYL SULFOXIDE × 4 EDO 1,2-ETHANEDIOL × 8 808 N-[(2S)-5-{[5-(trifluoromethyl)furan-2-yl]methyl}-2,3-dihydro-1H-inden-2-yl]propane-2-sulfonamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；18% PEG 4000, 50mM Lithium Sulphate, 2.5% Glycerol, 100mM Sodium Cacodylate pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.87 Å R-free 0.281 |
| 3RTF Chlorowillardiine bound to the ligand binding domain of GluA2 Deposited 2011-05-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
414–527（114 aa）
Fragment：SEE REMARK 999
Chain B
653–794（142 aa）
Fragment：SEE REMARK 999
Chain D
414–527（114 aa）
Fragment：SEE REMARK 999
Chain D
653–794（142 aa）
Fragment：SEE REMARK 999
|
Not recorded | CWD 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, 0.1 M sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.70 Å R-free 0.203 |
| 3RTF Chlorowillardiine bound to the ligand binding domain of GluA2 Deposited 2011-05-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
414–527（114 aa）
Fragment：SEE REMARK 999
Chain F
653–794（142 aa）
Fragment：SEE REMARK 999
|
Not recorded | CWD 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, 0.1 M sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.70 Å R-free 0.203 |
| 3RTW Nitrowillardiine bound to the ligand binding domain of GluA2 Deposited 2011-05-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
414–527（114 aa）
Fragment：SEE REMARK 999
Chain B
653–794（142 aa）
Fragment：SEE REMARK 999
Chain D
414–527（114 aa）
Fragment：SEE REMARK 999
Chain D
653–794（142 aa）
Fragment：SEE REMARK 999
|
Not recorded | NWD 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine × 2 ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, 0.1 M sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.10 Å R-free 0.259 |
| 3RTW Nitrowillardiine bound to the ligand binding domain of GluA2 Deposited 2011-05-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
414–527（114 aa）
Fragment：SEE REMARK 999
Chain F
653–794（142 aa）
Fragment：SEE REMARK 999
|
Not recorded | NWD 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, 0.1 M sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.10 Å R-free 0.259 |
| 3T93 Glutamate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 Deposited 2011-08-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
414–527（114 aa）
Fragment：SEE REMARK 999
Chain B
653–794（142 aa）
Fragment：SEE REMARK 999
Chain D
414–527（114 aa）
Fragment：SEE REMARK 999
Chain D
653–794（142 aa）
Fragment：SEE REMARK 999
|
Mutation：A473C/S673C Mutation：A473C/S673C Mutation：A473C/S673C Mutation：A473C/S673C | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.91 Å R-free 0.229 |
| 3T93 Glutamate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 Deposited 2011-08-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
414–527（114 aa）
Fragment：SEE REMARK 999
Chain F
653–794（142 aa）
Fragment：SEE REMARK 999
|
Mutation：A473C/S673C Mutation：A473C/S673C | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.91 Å R-free 0.229 |
| 3T96 Iodowillardiine bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 Deposited 2011-08-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
414–527（114 aa）
Fragment：SEE REMARK 999
Chain B
653–794（142 aa）
Fragment：SEE REMARK 999
Chain D
414–527（114 aa）
Fragment：SEE REMARK 999
Chain D
653–794（142 aa）
Fragment：SEE REMARK 999
|
Mutation：A473C/S673C Mutation：A473C/S673C Mutation：A473C/S673C Mutation：A473C/S673C | IWD 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.87 Å R-free 0.219 |
| 3T96 Iodowillardiine bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 Deposited 2011-08-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
414–527（114 aa）
Fragment：SEE REMARK 999
Chain F
653–794（142 aa）
Fragment：SEE REMARK 999
|
Mutation：A473C/S673C Mutation：A473C/S673C | IWD 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.87 Å R-free 0.219 |
| 3T9H Kainate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 Deposited 2011-08-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
414–527（114 aa）
Fragment：SEE REMARK 999
Chain B
653–794（142 aa）
Fragment：SEE REMARK 999
Chain D
414–527（114 aa）
Fragment：SEE REMARK 999
Chain D
653–794（142 aa）
Fragment：SEE REMARK 999
|
Mutation：A473C/S673C Mutation：A473C/S673C Mutation：A473C/S673C Mutation：A473C/S673C | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.02 Å R-free 0.235 |
| 3T9H Kainate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 Deposited 2011-08-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
414–527（114 aa）
Fragment：SEE REMARK 999
Chain F
653–794（142 aa）
Fragment：SEE REMARK 999
|
Mutation：A473C/S673C Mutation：A473C/S673C | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.02 Å R-free 0.235 |
| 3T9U CNQX bound to an oxidized double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 Deposited 2011-08-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
414–527（114 aa）
Fragment：SEE REMARK 999
Chain A
653–794（142 aa）
Fragment：SEE REMARK 999
Chain B
414–527（114 aa）
Fragment：SEE REMARK 999
Chain B
653–794（142 aa）
Fragment：SEE REMARK 999
|
Mutation：A473C/S673C Mutation：A473C/S673C Mutation：A473C/S673C Mutation：A473C/S673C | CNI 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile × 2 ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.97 Å R-free 0.219 |
| 3T9U CNQX bound to an oxidized double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 Deposited 2011-08-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
414–527（114 aa）
Fragment：SEE REMARK 999
Chain C
653–794（142 aa）
Fragment：SEE REMARK 999
|
Mutation：A473C/S673C Mutation：A473C/S673C | CNI 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.97 Å R-free 0.219 |
| 3T9V CNQX bound to a reduced double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 Deposited 2011-08-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
414–527（114 aa）
Fragment：SEE REMARK 999
Chain A
653–794（142 aa）
Fragment：SEE REMARK 999
Chain B
414–527（114 aa）
Fragment：SEE REMARK 999
Chain B
653–794（142 aa）
Fragment：SEE REMARK 999
|
Mutation：A473C/S673C Mutation：A473C/S673C Mutation：A473C/S673C Mutation：A473C/S673C | CNI 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.98 Å R-free 0.238 |
| 3T9X Glutamate bound to a double cysteine mutant (V484C/E657C) of the ligand binding domain of GluA2 Deposited 2011-08-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
414–527（114 aa）
Fragment：SEE REMARK 999
Chain B
653–794（142 aa）
Fragment：SEE REMARK 999
Chain F
414–527（114 aa）
Fragment：SEE REMARK 999
Chain F
653–794（142 aa）
Fragment：SEE REMARK 999
|
Mutation：V505C/E678C Mutation：V505C/E678C Mutation：V505C/E678C Mutation：V505C/E678C | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.82 Å R-free 0.240 |
| 3T9X Glutamate bound to a double cysteine mutant (V484C/E657C) of the ligand binding domain of GluA2 Deposited 2011-08-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
414–527（114 aa）
Fragment：SEE REMARK 999
Chain D
653–794（142 aa）
Fragment：SEE REMARK 999
|
Mutation：V505C/E678C Mutation：V505C/E678C | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.82 Å R-free 0.240 |
| 3TDJ Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-97 at 1.95 A resolution Deposited 2011-08-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain, UNP residues 413-527 and 653-796
Chain A
653–796（144 aa）
Fragment：Ligand binding domain, UNP residues 413-527 and 653-796
Chain B
413–527（115 aa）
Fragment：Ligand binding domain, UNP residues 413-527 and 653-796
Chain B
653–796（144 aa）
Fragment：Ligand binding domain, UNP residues 413-527 and 653-796
|
Mutation：L483Y, N754S Mutation：L483Y, N754S Mutation：L483Y, N754S Mutation：L483Y, N754S | GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 3 CL CHLORIDE ION × 5 GOL GLYCEROL × 11 3TJ 4-ethyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；15.2% PEG4000, 0.3 M lithium sulfate and 0.1 M phosphate-citrate., pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.95 Å R-free 0.215 |
| 3TKD Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and cyclothiazide at 1.45 A resolution Deposited 2011-08-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain
Chain A
653–795（143 aa）
Fragment：Ligand binding domain
Chain B
413–527（115 aa）
Fragment：Ligand binding domain
Chain B
653–795（143 aa）
Fragment：Ligand binding domain
|
Mutation：L483Y, N754S Mutation：L483Y, N754S Mutation：L483Y, N754S Mutation：L483Y, N754S | GLU GLUTAMIC ACID × 2 CYZ CYCLOTHIAZIDE × 2 SO4 SULFATE ION × 8 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；20% PEG4000, 0.3M ammonium sulfate, 0.1M phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.45 Å R-free 0.180 |
| 3TZA Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 1.9A resolution Deposited 2011-09-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain, UNP resiudes 413-527,UNP residues 653-796
Chain A
653–796（144 aa）
Fragment：Ligand binding domain, UNP resiudes 413-527,UNP residues 653-796
Chain B
413–527（115 aa）
Fragment：Ligand binding domain, UNP resiudes 413-527,UNP residues 653-796
Chain B
653–796（144 aa）
Fragment：Ligand binding domain, UNP resiudes 413-527,UNP residues 653-796
|
Not recorded | TZG (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid × 2 SO4 SULFATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；15.2% PEG4000, 0.1M ammonium sulfate, 0.1M sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.90 Å R-free 0.230 |
| 4FAT Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Deposited 2012-05-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：ligand binding domain
Chain A
653–796（144 aa）
Fragment：ligand binding domain
|
Mutation：delta 528-652 Mutation：delta 528-652 | GLU GLUTAMIC ACID × 2 496 2-({[4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide × 2 SO4 SULFATE ION × 6 GOL GLYCEROL × 8 LI LITHIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.1；298 K；18% PEG 4000, 50mM Lithium Sulphate, 100mM Sodium Cacodylate, pH 4.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.40 Å R-free 0.209 |
| 4G8M Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the agonist CBG-IV at 2.05A resolution Deposited 2012-07-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：UNP residues 413-527, 653-796
Chain A
653–796（144 aa）
Fragment：UNP residues 413-527, 653-796
Chain B
413–527（115 aa）
Fragment：UNP residues 413-527, 653-796
Chain B
653–796（144 aa）
Fragment：UNP residues 413-527, 653-796
|
Not recorded | G8M (1S,2R)-2-[(S)-amino(carboxy)methyl]cyclobutanecarboxylic acid × 2 SO4 SULFATE ION × 7 CL CHLORIDE ION × 3 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；24.4% PEG4000, 0.3M lithium sulfate, 0.1M phosphate-citrate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 2.05 Å R-free 0.228 |
| 4G8M Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the agonist CBG-IV at 2.05A resolution Deposited 2012-07-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：UNP residues 413-527, 653-796
Chain A
653–796（144 aa）
Fragment：UNP residues 413-527, 653-796
Chain B
413–527（115 aa）
Fragment：UNP residues 413-527, 653-796
Chain B
653–796（144 aa）
Fragment：UNP residues 413-527, 653-796
|
Not recorded | G8M (1S,2R)-2-[(S)-amino(carboxy)methyl]cyclobutanecarboxylic acid × 2 SO4 SULFATE ION × 7 CL CHLORIDE ION × 3 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；24.4% PEG4000, 0.3M lithium sulfate, 0.1M phosphate-citrate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 2.05 Å R-free 0.228 |
| 4GXS Ligand binding domain of GluA2 (AMPA/glutamate receptor) bound to (-)-kaitocephalin Deposited 2012-09-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
414–527（114 aa）
Fragment：UNP Residues 652-794
Chain B
653–794（142 aa）
Fragment：UNP Residues 652-794
Chain D
414–527（114 aa）
Fragment：UNP Residues 652-794
Chain D
653–794（142 aa）
Fragment：UNP Residues 652-794
|
Not recorded | 0YS (5R)-2-[(1S,2R)-2-amino-2-carboxy-1-hydroxyethyl]-5-{(2S)-2-carboxy-2-[(3,5-dichloro-4-hydroxybenzoyl)amino]ethyl}-L-proline × 2 ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18% PEG 8K, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.96 Å R-free 0.225 |
| 4H8J Structure of GluA2-LBD in complex with MES Deposited 2012-09-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：SEE REMARK 999
Chain A
653–797（145 aa）
Fragment：SEE REMARK 999
Chain B
413–527（115 aa）
Fragment：SEE REMARK 999
Chain B
653–797（145 aa）
Fragment：SEE REMARK 999
|
Not recorded | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 6 EDO 1,2-ETHANEDIOL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；23-27% w/v PEG3350, 0.2 M lithium sulfate, MES sodium, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.80 Å R-free 0.221 |
| 4H8J Structure of GluA2-LBD in complex with MES Deposited 2012-09-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
413–527（115 aa）
Fragment：SEE REMARK 999
Chain C
653–797（145 aa）
Fragment：SEE REMARK 999
Chain D
413–527（115 aa）
Fragment：SEE REMARK 999
Chain D
653–797（145 aa）
Fragment：SEE REMARK 999
|
Not recorded | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 6 EDO 1,2-ETHANEDIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；23-27% w/v PEG3350, 0.2 M lithium sulfate, MES sodium, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.80 Å R-free 0.221 |
| 4IGT Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the agonist ZA302 at 1.24A resolution Deposited 2012-12-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand-binding domain, UNP RESIDUES 413-527, 653-796
Chain A
653–796（144 aa）
Fragment：Ligand-binding domain, UNP RESIDUES 413-527, 653-796
|
Not recorded | 3ZA (4R)-4-{3-[hydroxy(methyl)amino]-3-oxopropyl}-L-glutamic acid × 2 SO4 SULFATE ION × 6 LI LITHIUM ION × 2 GOL GLYCEROL × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；15.2% PEG 4000, 0.1M Li2SO4, 0.1M phosphate-citrate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 1.24 Å R-free 0.155 |
| 4ISU Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution. Deposited 2013-01-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand-binding domain
Chain A
653–796（144 aa）
Fragment：Ligand-binding domain
Chain C
413–527（115 aa）
Fragment：Ligand-binding domain
Chain C
653–796（144 aa）
Fragment：Ligand-binding domain
|
Not recorded | IKM (4aS,5aR,6R,8aS,8bS)-5a-(carboxymethyl)-8-oxo-2,4a,5a,6,7,8,8a,8b-octahydro-1H-pyrrolo[3',4':4,5]furo[3,2-b]pyridine-6-carboxylic acid × 1 SO4 SULFATE ION × 3 CL CHLORIDE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；20% PEG4000, 0.1M Lithium sulfate, 0.1M phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 2.30 Å R-free 0.258 |
| 4ISU Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution. Deposited 2013-01-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：Ligand-binding domain
Chain B
653–796（144 aa）
Fragment：Ligand-binding domain
Chain D
413–527（115 aa）
Fragment：Ligand-binding domain
Chain D
653–796（144 aa）
Fragment：Ligand-binding domain
|
Not recorded | IKM (4aS,5aR,6R,8aS,8bS)-5a-(carboxymethyl)-8-oxo-2,4a,5a,6,7,8,8a,8b-octahydro-1H-pyrrolo[3',4':4,5]furo[3,2-b]pyridine-6-carboxylic acid × 1 SO4 SULFATE ION × 3 CL CHLORIDE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；20% PEG4000, 0.1M Lithium sulfate, 0.1M phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 2.30 Å R-free 0.258 |
| 4ISU Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution. Deposited 2013-01-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Fragment：Ligand-binding domain
Chain A
653–796（144 aa）
Fragment：Ligand-binding domain
|
Not recorded | IKM (4aS,5aR,6R,8aS,8bS)-5a-(carboxymethyl)-8-oxo-2,4a,5a,6,7,8,8a,8b-octahydro-1H-pyrrolo[3',4':4,5]furo[3,2-b]pyridine-6-carboxylic acid × 1 SO4 SULFATE ION × 1 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；20% PEG4000, 0.1M Lithium sulfate, 0.1M phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 2.30 Å R-free 0.258 |
| 4ISU Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution. Deposited 2013-01-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
413–527（115 aa）
Fragment：Ligand-binding domain
Chain D
653–796（144 aa）
Fragment：Ligand-binding domain
|
Not recorded | SO4 SULFATE ION × 1 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；20% PEG4000, 0.1M Lithium sulfate, 0.1M phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 2.30 Å R-free 0.258 |
| 4ISU Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution. Deposited 2013-01-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
413–527（115 aa）
Fragment：Ligand-binding domain
Chain C
653–796（144 aa）
Fragment：Ligand-binding domain
|
Not recorded | SO4 SULFATE ION × 2 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；20% PEG4000, 0.1M Lithium sulfate, 0.1M phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 2.30 Å R-free 0.258 |
| 4ISU Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution. Deposited 2013-01-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
413–527（115 aa）
Fragment：Ligand-binding domain
Chain B
653–796（144 aa）
Fragment：Ligand-binding domain
|
Not recorded | IKM (4aS,5aR,6R,8aS,8bS)-5a-(carboxymethyl)-8-oxo-2,4a,5a,6,7,8,8a,8b-octahydro-1H-pyrrolo[3',4':4,5]furo[3,2-b]pyridine-6-carboxylic acid × 1 SO4 SULFATE ION × 2 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；20% PEG4000, 0.1M Lithium sulfate, 0.1M phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
Resolution 2.30 Å R-free 0.258 |
| 4IY5 Crystal structure of the glua2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and CX516 at 2.0 A resolution Deposited 2013-01-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain, UNP RESIDUES 413-527, 653-796
Chain A
653–796（144 aa）
Fragment：Ligand binding domain, UNP RESIDUES 413-527, 653-796
Chain B
413–527（115 aa）
Fragment：Ligand binding domain, UNP RESIDUES 413-527, 653-796
Chain B
653–796（144 aa）
Fragment：Ligand binding domain, UNP RESIDUES 413-527, 653-796
|
Mutation：L94Y, N242S Mutation：L94Y, N242S Mutation：L94Y, N242S Mutation：L94Y, N242S | GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 5 GOL GLYCEROL × 3 CL CHLORIDE ION × 3 CX5 piperidin-1-yl(quinoxalin-6-yl)methanone × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；24.4% PEG 4000, 0.3M lithium sulfate, 0.1M phosphate-citrate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 2.00 Å R-free 0.200 |
| 4IY6 Crystal structure of the GLUA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and ME-CX516 at 1.72 A resolution Deposited 2013-01-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain, UNP RESIDUES 413-527, 653-796
Chain A
653–796（144 aa）
Fragment：Ligand binding domain, UNP RESIDUES 413-527, 653-796
|
Mutation：L94Y, N242S Mutation：L94Y, N242S | MQR [(3R)-3-methylpiperidin-1-yl](quinoxalin-6-yl)methanone × 2 MQS [(3S)-3-methylpiperidin-1-yl](quinoxalin-6-yl)methanone × 4 GLU GLUTAMIC ACID × 2 GOL GLYCEROL × 2 SO4 SULFATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；15.2% PEG 4000, 0.3M lithium sulfate, 0.1M sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.72 Å R-free 0.168 |
| 4L17 GluA2-L483Y-A665C ligand-binding domain in complex with the antagonist DNQX Deposited 2013-06-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain (UNP residues 413-527, 653-796)
Chain A
653–796（144 aa）
Fragment：Ligand binding domain (UNP residues 413-527, 653-796)
Chain C
413–527（115 aa）
Fragment：Ligand binding domain (UNP residues 413-527, 653-796)
Chain C
653–796（144 aa）
Fragment：Ligand binding domain (UNP residues 413-527, 653-796)
|
Mutation：L94Y, A153C Mutation：L94Y, A153C Mutation：L94Y, A153C Mutation：L94Y, A153C | DNQ 6,7-DINITROQUINOXALINE-2,3-DIONE × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；19% PEG 1450, 0.3M lithium sulfate, 0.1M cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 2.80 Å R-free 0.244 |
| 4L17 GluA2-L483Y-A665C ligand-binding domain in complex with the antagonist DNQX Deposited 2013-06-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
413–527（115 aa）
Fragment：Ligand binding domain (UNP residues 413-527, 653-796)
Chain E
653–796（144 aa）
Fragment：Ligand binding domain (UNP residues 413-527, 653-796)
|
Mutation：L94Y, A153C Mutation：L94Y, A153C | DNQ 6,7-DINITROQUINOXALINE-2,3-DIONE × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；19% PEG 1450, 0.3M lithium sulfate, 0.1M cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 2.80 Å R-free 0.244 |
| 4L17 GluA2-L483Y-A665C ligand-binding domain in complex with the antagonist DNQX Deposited 2013-06-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
413–527（115 aa）
Fragment：Ligand binding domain (UNP residues 413-527, 653-796)
Chain G
653–796（144 aa）
Fragment：Ligand binding domain (UNP residues 413-527, 653-796)
|
Mutation：L94Y, A153C Mutation：L94Y, A153C | DNQ 6,7-DINITROQUINOXALINE-2,3-DIONE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；19% PEG 1450, 0.3M lithium sulfate, 0.1M cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 2.80 Å R-free 0.244 |
| 4LZ5 Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators Deposited 2013-07-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
404–527（124 aa）
Fragment：SEE REMARK 999
Chain A
653–796（144 aa）
Fragment：SEE REMARK 999
Chain C
404–527（124 aa）
Fragment：SEE REMARK 999
Chain C
653–796（144 aa）
Fragment：SEE REMARK 999
|
Mutation：G389R,L390G,E391A Mutation：G389R,L390G,E391A Mutation：G389R,L390G,E391A Mutation：G389R,L390G,E391A | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 2 1YV N-[(2R)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；1 uL 7 mg/mL protein in 10 mM (S)-Glu, 10 mM HEPES, pH 7.5, 20 mM sodium chloride, 1 mM EDTA, 150 uM ligand (from 30 mM DMSO stock) + 1 uL reservoir (10% PEG8000, 0.1 M zinc acetate, 0.1 M sodium acetate, pH 5.5), crystals appeared in 3-5 days, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.50 Å R-free 0.203 |
| 4LZ5 Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators Deposited 2013-07-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
404–527（124 aa）
Fragment：SEE REMARK 999
Chain B
653–796（144 aa）
Fragment：SEE REMARK 999
|
Mutation：G389R,L390G,E391A Mutation：G389R,L390G,E391A | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 6 1YV N-[(2R)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；1 uL 7 mg/mL protein in 10 mM (S)-Glu, 10 mM HEPES, pH 7.5, 20 mM sodium chloride, 1 mM EDTA, 150 uM ligand (from 30 mM DMSO stock) + 1 uL reservoir (10% PEG8000, 0.1 M zinc acetate, 0.1 M sodium acetate, pH 5.5), crystals appeared in 3-5 days, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.50 Å R-free 0.203 |
| 4LZ7 Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators Deposited 2013-07-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
404–527（124 aa）
Fragment：SEE REMARK 999
Chain A
653–796（144 aa）
Fragment：SEE REMARK 999
Chain C
404–527（124 aa）
Fragment：SEE REMARK 999
Chain C
653–796（144 aa）
Fragment：SEE REMARK 999
|
Mutation：G389R,L390G,E391A Mutation：G389R,L390G,E391A Mutation：G389R,L390G,E391A Mutation：G389R,L390G,E391A | ZN ZINC ION × 3 GLU GLUTAMIC ACID × 2 1YW N-({(5S)-3-[3-fluoro-4-(pyrrolidin-1-yl)phenyl]-4,5-dihydro-1,2-oxazol-5-yl}methyl)acetamide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；1 uL 7 mg/mL protein in 10 mM (S)-Glu, 10 mM HEPES, pH 7.5, 20 mM sodium chloride, 1 mM EDTA, 150 uM ligand (from 30 mM DMSO stock) + 1 uL reservoir (10% PEG8000, 0.1 M zinc acetate, 0.1 M sodium acetate, pH 5.5), crystals appeared in 3-5 days, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.10 Å R-free 0.240 |
| 4LZ7 Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators Deposited 2013-07-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
404–527（124 aa）
Fragment：SEE REMARK 999
Chain B
653–796（144 aa）
Fragment：SEE REMARK 999
|
Mutation：G389R,L390G,E391A Mutation：G389R,L390G,E391A | ZN ZINC ION × 4 GLU GLUTAMIC ACID × 2 1YW N-({(5S)-3-[3-fluoro-4-(pyrrolidin-1-yl)phenyl]-4,5-dihydro-1,2-oxazol-5-yl}methyl)acetamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；1 uL 7 mg/mL protein in 10 mM (S)-Glu, 10 mM HEPES, pH 7.5, 20 mM sodium chloride, 1 mM EDTA, 150 uM ligand (from 30 mM DMSO stock) + 1 uL reservoir (10% PEG8000, 0.1 M zinc acetate, 0.1 M sodium acetate, pH 5.5), crystals appeared in 3-5 days, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.10 Å R-free 0.240 |
| 4LZ8 Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators Deposited 2013-07-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
404–527（124 aa）
Fragment：SEE REMARK 999
Chain A
653–796（144 aa）
Fragment：SEE REMARK 999
Chain C
404–527（124 aa）
Fragment：SEE REMARK 999
Chain C
653–796（144 aa）
Fragment：SEE REMARK 999
|
Mutation：G389R,L390G,E391A Mutation：G389R,L390G,E391A Mutation：G389R,L390G,E391A Mutation：G389R,L390G,E391A | GLU GLUTAMIC ACID × 2 1YX N-[(3S)-1-{2-fluoro-4-[(5S)-5-{[(propan-2-ylsulfonyl)amino]methyl}-4,5-dihydro-1,2-oxazol-3-yl]phenyl}pyrrolidin-3-yl]acetamide × 1 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；1 uL 7 mg/mL protein in 10 mM (S)-Glu, 10 mM HEPES, pH 7.5, 20 mM sodium chloride, 1 mM EDTA, 150 uM ligand (from 30 mM DMSO stock) + 1 uL reservoir (10% PEG8000, 0.1 M zinc acetate, 0.1 M sodium acetate, pH 5.5), crystals appeared in 3-5 days, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.85 Å R-free 0.232 |
| 4LZ8 Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators Deposited 2013-07-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
404–527（124 aa）
Fragment：SEE REMARK 999
Chain B
653–796（144 aa）
Fragment：SEE REMARK 999
|
Mutation：G389R,L390G,E391A Mutation：G389R,L390G,E391A | GLU GLUTAMIC ACID × 2 1YX N-[(3S)-1-{2-fluoro-4-[(5S)-5-{[(propan-2-ylsulfonyl)amino]methyl}-4,5-dihydro-1,2-oxazol-3-yl]phenyl}pyrrolidin-3-yl]acetamide × 2 ZN ZINC ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；1 uL 7 mg/mL protein in 10 mM (S)-Glu, 10 mM HEPES, pH 7.5, 20 mM sodium chloride, 1 mM EDTA, 150 uM ligand (from 30 mM DMSO stock) + 1 uL reservoir (10% PEG8000, 0.1 M zinc acetate, 0.1 M sodium acetate, pH 5.5), crystals appeared in 3-5 days, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.85 Å R-free 0.232 |
| 4N07 Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-344 at 1.87 A resolution Deposited 2013-10-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：unp residues 413-527, unp reisdues 653-796
Chain A
653–796（144 aa）
Fragment：unp residues 413-527, unp reisdues 653-796
|
Mutation：L504Y, N755S Mutation：L504Y, N755S | 2J9 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2 GLU GLUTAMIC ACID × 2 ACT ACETATE ION × 12 ZN ZINC ION × 8 CAC CACODYLATE ION × 2 GOL GLYCEROL × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16.5% PEG4000, 0.15 M zinc acetate, 0.1 M cacodylate, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.87 Å R-free 0.211 |
| 4N07 Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-344 at 1.87 A resolution Deposited 2013-10-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：unp residues 413-527, unp reisdues 653-796
Chain B
653–796（144 aa）
Fragment：unp residues 413-527, unp reisdues 653-796
Chain C
413–527（115 aa）
Fragment：unp residues 413-527, unp reisdues 653-796
Chain C
653–796（144 aa）
Fragment：unp residues 413-527, unp reisdues 653-796
|
Mutation：L504Y, N755S Mutation：L504Y, N755S Mutation：L504Y, N755S Mutation：L504Y, N755S | 2J9 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2 GLU GLUTAMIC ACID × 2 ACT ACETATE ION × 7 ZN ZINC ION × 6 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16.5% PEG4000, 0.15 M zinc acetate, 0.1 M cacodylate, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.87 Å R-free 0.211 |
| 4O3A Crystal structure of the glua2 ligand-binding domain in complex with L-aspartate at 1.80 a resolution Deposited 2013-12-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain (unp residues 413-527 and unp residues 653-736)
Chain A
653–796（144 aa）
Fragment：Ligand binding domain (unp residues 413-527 and unp residues 653-736)
|
Not recorded | GOL GLYCEROL × 12 ASP ASPARTIC ACID × 2 ZN ZINC ION × 6 ACT ACETATE ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；24.4 % PEG 4000, 0.1 M zinc acetate and 0.1 M sodium acetate., pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.80 Å R-free 0.188 |
| 4O3A Crystal structure of the glua2 ligand-binding domain in complex with L-aspartate at 1.80 a resolution Deposited 2013-12-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
413–527（115 aa）
Fragment：Ligand binding domain (unp residues 413-527 and unp residues 653-736)
Chain B
653–796（144 aa）
Fragment：Ligand binding domain (unp residues 413-527 and unp residues 653-736)
|
Not recorded | GOL GLYCEROL × 4 ASP ASPARTIC ACID × 1 ZN ZINC ION × 2 ACT ACETATE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 3 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；24.4 % PEG 4000, 0.1 M zinc acetate and 0.1 M sodium acetate., pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.80 Å R-free 0.188 |
| 4O3A Crystal structure of the glua2 ligand-binding domain in complex with L-aspartate at 1.80 a resolution Deposited 2013-12-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
413–527（115 aa）
Fragment：Ligand binding domain (unp residues 413-527 and unp residues 653-736)
Chain C
653–796（144 aa）
Fragment：Ligand binding domain (unp residues 413-527 and unp residues 653-736)
|
Not recorded | GOL GLYCEROL × 2 ASP ASPARTIC ACID × 1 ZN ZINC ION × 4 ACT ACETATE ION × 6 PEG DI(HYDROXYETHYL)ETHER × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；24.4 % PEG 4000, 0.1 M zinc acetate and 0.1 M sodium acetate., pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.80 Å R-free 0.188 |
| 4O3B Crystal structure of an open/closed glua2 ligand-binding domain dimer at 1.91 A resolution Deposited 2013-12-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain (unp residues 413-527 and unp residues 653-736)
Chain A
653–796（144 aa）
Fragment：Ligand binding domain (unp residues 413-527 and unp residues 653-736)
Chain B
413–527（115 aa）
Fragment：Ligand binding domain (unp residues 413-527 and unp residues 653-736)
Chain B
653–796（144 aa）
Fragment：Ligand binding domain (unp residues 413-527 and unp residues 653-736)
|
Not recorded | SO4 SULFATE ION × 4 GOL GLYCEROL × 6 CL CHLORIDE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 ACT ACETATE ION × 1 GLU GLUTAMIC ACID × 1 PG4 TETRAETHYLENE GLYCOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；20% PEG 4000, 0.1 M lithium sulfate and 0.1 M phosphate-citrate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.91 Å R-free 0.178 |
| 4O3C Crystal structure of the GLUA2 ligand-binding domain in complex with L-aspartate at 1.50 A resolution Deposited 2013-12-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain (unp residues 413-527 and unp residues 653-796)
Chain A
653–796（144 aa）
Fragment：Ligand binding domain (unp residues 413-527 and unp residues 653-796)
|
Not recorded | ASP ASPARTIC ACID × 2 CL CHLORIDE ION × 2 GOL GLYCEROL × 2 ACT ACETATE ION × 2 LI LITHIUM ION × 2 SO4 SULFATE ION × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；20% PEG 4000, 0.1 M lithium sulfate and 0.1 M phosphate-citrate., pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
|
Resolution 1.50 Å R-free 0.158 |
| 4Q30 Nitrowillardiine bound to the ligand binding domain of GluA2 at pH 3.5 Deposited 2014-04-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
414–527（114 aa）
Chain B
653–794（142 aa）
Chain D
414–527（114 aa）
Chain D
653–794（142 aa）
|
Not recorded | NWD 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 3.5；277 K；14-15% PEG 8K, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 3.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.03 Å R-free 0.230 |
| 4Q30 Nitrowillardiine bound to the ligand binding domain of GluA2 at pH 3.5 Deposited 2014-04-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
414–527（114 aa）
Chain F
653–794（142 aa）
|
Not recorded | NWD 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 3.5；277 K；14-15% PEG 8K, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 3.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.03 Å R-free 0.230 |
| 4U1O GluA2flip sLBD complexed with kainate and (R,R)-2b crystal form C Deposited 2014-07-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Chain A
653–796（144 aa）
|
Not recorded | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 1 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Na cacodylate, pH 6.5, 1.26 M ammonium sulfate
|
Resolution 1.85 Å R-free 0.209 |
| 4U1W Full length GluA2-kainate-(R,R)-2b complex crystal form A Deposited 2014-07-16 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M MES, pH 6.5, 6%PEG6K, 3% TMAO, 0.006M Taurine
|
Resolution 3.25 Å R-free 0.316 |
| 4U1X Full length GluA2-kainate-(R,R)-2b complex crystal form B Deposited 2014-07-16 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M MES, pH 6.2, 5.25% PEG6K, 3% TMAO, 0.006 M Taurine, 20 mM MnCl2
|
Resolution 3.30 Å R-free 0.289 |
| 4U1Y Full length GluA2-FW-(R,R)-2b complex Deposited 2014-07-16 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M imidazole pH 6.2, 9% PEG1450, 3% TMAO
|
Resolution 3.90 Å R-free 0.303 |
| 4U1Z GluA2flip sLBD complexed with kainate and (R,R)-2b crystal form D Deposited 2014-07-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Chain A
653–796（144 aa）
|
Not recorded | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 1 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Na acetate, pH 4.5, 25% PEG3350
|
Resolution 1.94 Å R-free 0.208 |
| 4U21 GluA2flip sLBD complexed with FW and (R,R)-2b crystal form E Deposited 2014-07-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
654–796（143 aa）
Chain B
413–527（115 aa）
Chain B
654–796（143 aa）
|
Mutation：A796S Mutation：A796S Mutation：A796S Mutation：A796S | FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；phosphate-citrate, pH 4.2, 0.2 M Li sulfate, 20% PEG1K
|
Resolution 1.39 Å R-free 0.198 |
| 4U22 GluA2flip sLBD complexed with FW and (R,R)-2b crystal form D Deposited 2014-07-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Chain A
653–796（144 aa）
|
Mutation：A796S Mutation：A796S | FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 1 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Na acetate, pH 4.5, 20% PEG3K
|
Resolution 1.44 Å R-free 0.217 |
| 4U23 GluA2flip sLBD complexed with FW and (R,R)-2b crystal form F Deposited 2014-07-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Chain A
653–796（144 aa）
|
Mutation：A796S Mutation：A796S | FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 1 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M bicine/Trizma base, pH 8.5, 0.09 M Morpheus nitrate-phosphate-sulfate, 10% w/v PEG8K, 20% (v/v) ethylene glycol
|
Resolution 1.67 Å R-free 0.250 |
| 4U2P Full-length AMPA subtype ionotropic glutamate receptor GluA2 in the apo state Deposited 2014-07-17 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277.15 K；0.1 M MES, 5.8-6.2% PEG6000, 5% TMAO, 0.1-0.3 M sodium acetate
|
Resolution 3.24 Å R-free 0.288 |
| 4U2Q Full-length AMPA subtype ionotropic glutamate receptor GluA2 in complex with partial agonist kainate Deposited 2014-07-17 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277.15 K；0.1 M MES, 4.8-5.3% PEG6000, 3.5% TMAO, 6 mM taurine
|
Resolution 3.52 Å R-free 0.318 |
| 4U2R Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state Deposited 2014-07-17 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
413–527（115 aa）
Chain A
653–796（144 aa）
Chain B
413–527（115 aa）
Chain B
653–796（144 aa）
Chain C
413–527（115 aa）
Chain C
653–796（144 aa）
Chain D
413–527（115 aa）
Chain D
653–796（144 aa）
|
Mutation：A796S,A796S Mutation：A796S,A796S Mutation：A796S,A796S Mutation：A796S,A796S Mutation：A796S,A796S Mutation：A796S,A796S Mutation：A796S,A796S Mutation：A796S,A796S | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；17-20% PEG8000, 0.2M lithium sulfate, 0.1 M sodium acetate
|
Resolution 1.41 Å R-free 0.232 |
| 4U2R Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state Deposited 2014-07-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
413–527（115 aa）
Chain B
653–796（144 aa）
|
Mutation：A796S,A796S Mutation：A796S,A796S | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；17-20% PEG8000, 0.2M lithium sulfate, 0.1 M sodium acetate
|
Resolution 1.41 Å R-free 0.232 |
| 4U2R Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state Deposited 2014-07-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Chain A
653–796（144 aa）
|
Mutation：A796S,A796S Mutation：A796S,A796S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；17-20% PEG8000, 0.2M lithium sulfate, 0.1 M sodium acetate
|
Resolution 1.41 Å R-free 0.232 |
| 4U2R Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state Deposited 2014-07-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
413–527（115 aa）
Chain C
653–796（144 aa）
|
Mutation：A796S,A796S Mutation：A796S,A796S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；17-20% PEG8000, 0.2M lithium sulfate, 0.1 M sodium acetate
|
Resolution 1.41 Å R-free 0.232 |
| 4U2R Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state Deposited 2014-07-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
413–527（115 aa）
Chain D
653–796（144 aa）
|
Mutation：A796S,A796S Mutation：A796S,A796S | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；17-20% PEG8000, 0.2M lithium sulfate, 0.1 M sodium acetate
|
Resolution 1.41 Å R-free 0.232 |
| 4U4F Structure of GluA2* in complex with partial agonist (S)-5-Nitrowillardiine Deposited 2014-07-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | NWD 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；11-14% (w/v) PEG 3,000, 50 mM lithium sulfate, 0.1 M tricine
|
Resolution 4.79 Å R-free 0.262 |
| 4U4G Structure of GluA2* in complex with competitive antagonist ZK 200775 Deposited 2014-07-23 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Fragment：UNP residues 25-847
Chain B
25–847（823 aa）
Fragment：UNP residues 25-847
Chain C
25–847（823 aa）
Fragment：UNP residues 25-847
Chain D
25–847（823 aa）
Fragment：UNP residues 25-847
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；277 K；7-11% PEG 20,000, 0.1 M MES
|
Resolution 4.49 Å R-free 0.248 |
| 4U4S Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM25 at 1.90 A resolution. Deposited 2014-07-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: Dimeric |
Chain A
413–527（115 aa）
Fragment：UNP residues 413-527, UNP residues 653-796
Chain A
653–796（144 aa）
Fragment：UNP residues 413-527, UNP residues 653-796
Chain B
413–527（115 aa）
Fragment：UNP residues 413-527, UNP residues 653-796
Chain B
653–796（144 aa）
Fragment：UNP residues 413-527, UNP residues 653-796
|
Mutation：yes Mutation：yes Mutation：yes Mutation：yes | 3C1 4-ethyl-3,4-dihydro-2H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide × 2 SO4 SULFATE ION × 3 GOL GLYCEROL × 4 ACT ACETATE ION × 8 CL CHLORIDE ION × 2 GLU GLUTAMIC ACID × 2 PEG DI(HYDROXYETHYL)ETHER × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；22% PEG4000, 0.2 M ammoniumsulfate, 0.1 M phosphate-citrate.
|
Resolution 1.90 Å R-free 0.208 |
| 4U4X Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM37 at 1.56 A resolution. Deposited 2014-07-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: Dimeric |
Chain A
413–527（115 aa）
Fragment：UNP residues 413-527, UNP residues 653-796
Chain A
653–796（144 aa）
Fragment：UNP residues 413-527, UNP residues 653-796
Chain B
413–527（115 aa）
Fragment：UNP residues 413-527, UNP residues 653-796
Chain B
653–796（144 aa）
Fragment：UNP residues 413-527, UNP residues 653-796
|
Mutation：yes Mutation：yes Mutation：yes Mutation：yes | 3C2 4-ethyl-3,4-dihydro-2H-pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide × 2 SO4 SULFATE ION × 5 GLU GLUTAMIC ACID × 2 ACT ACETATE ION × 4 GOL GLYCEROL × 3 PEG DI(HYDROXYETHYL)ETHER × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；24% PEG4000, 0.1 M ammoniumsulfate, 0.1 M phosphate-citrate
|
Resolution 1.56 Å R-free 0.175 |
| 4U5B Crystal structure of GluA2 A622T, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex Deposited 2014-07-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
25–845（821 aa）
Chain B
25–845（821 aa）
Chain C
25–845（821 aa）
Chain D
25–845（821 aa）
|
Not recorded | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M MES pH 5.8-6.3, 0.1 M NaCl, 5%-6% PEG3350
|
Resolution 3.50 Å R-free 0.261 |
| 4U5C Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist FW and postitive modulator (R,R)-2b complex Deposited 2014-07-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
25–845（821 aa）
Chain B
25–845（821 aa）
Chain C
25–845（821 aa）
Chain D
25–845（821 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M MES pH 5.8-6.3, 0.1 M NaCl, 5%-6% PEG3350
|
Resolution 3.69 Å R-free 0.254 |
| 4U5D Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex Deposited 2014-07-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
25–845（821 aa）
Chain B
25–845（821 aa）
Chain C
25–845（821 aa）
Chain D
25–845（821 aa）
|
Not recorded | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M MES pH 5.8-6.3, 0.1 M NaCl, 5%-6% PEG3350
|
Resolution 3.58 Å R-free 0.297 |
| 4U5E Crystal structure of GluA2 T625G, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex Deposited 2014-07-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
25–845（821 aa）
Chain B
25–845（821 aa）
Chain C
25–845（821 aa）
Chain D
25–845（821 aa）
|
Not recorded | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M MES pH 5.8-6.3, 0.1 M NaCl, 5%-6% PEG3350
|
Resolution 3.51 Å R-free 0.276 |
| 4U5F Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex, GluA2cryst2 construct Deposited 2014-07-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
25–848（824 aa）
Chain B
25–848（824 aa）
Chain C
25–848（824 aa）
Chain D
25–848（824 aa）
|
Not recorded | KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M MES pH 5.8-6.3, 0.1 M NaCl, 5%-6% PEG3350
|
Resolution 3.70 Å R-free 0.286 |
| 4UQ6 Electron density map of GluA2em in complex with LY451646 and glutamate Deposited 2014-06-20 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
22–847（826 aa）
Fragment：RESIDUES 22-847
Chain B
22–847（826 aa）
Fragment：RESIDUES 22-847
Chain C
22–847（826 aa）
Fragment：RESIDUES 22-847
Chain D
22–847（826 aa）
Fragment：RESIDUES 22-847
|
Not recorded | GLU GLUTAMIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；ETHANE
|
Resolution 12.80 Å |
| 4UQK Electron density map of GluA2em in complex with quisqualate and LY451646 Deposited 2014-06-24 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
22–847（826 aa）
Fragment：RESIDUES 22-847
Chain B
22–847（826 aa）
Fragment：RESIDUES 22-847
Chain C
22–847（826 aa）
Fragment：RESIDUES 22-847
Chain D
22–847（826 aa）
Fragment：RESIDUES 22-847
|
Not recorded | QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；ETHANE
|
Resolution 16.40 Å |
| 4X48 Crystal structure of GluR2 ligand-binding core Deposited 2014-12-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：Ligand binding domain, engineered single chain
Chain A
653–796（144 aa）
Fragment：Ligand binding domain, engineered single chain
Chain C
413–527（115 aa）
Fragment：Ligand binding domain, engineered single chain
Chain C
653–796（144 aa）
Fragment：Ligand binding domain, engineered single chain
|
Not recorded | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 3 XPF N-{(3S,4S)-4-[4-(5-cyanothiophen-2-yl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；The protein solution contained 7 mg/ml GluR2-S1S2J, 10mM (S)-Glu, 10mM HEPES (pH 7.5), 20mM NaCl and 1mM EDTA. Compound was added to a final concentration of 150micromolar from a 30mM DMSO stock. To this solution, an equal amount of reservoir solution containing 10% PEG 8000, 0.1 M ZnAc and 0.1M NaAc, pH 5.5 was added, and 2microlitre drops of this mixture were allowed to equilibrate by vapor diffusion over a 1mL reservoir. Crystals appeared in the drops in 3-5 days.
|
Resolution 1.89 Å R-free 0.197 |
| 4X48 Crystal structure of GluR2 ligand-binding core Deposited 2014-12-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：Ligand binding domain, engineered single chain
Chain B
653–796（144 aa）
Fragment：Ligand binding domain, engineered single chain
|
Not recorded | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 4 XPF N-{(3S,4S)-4-[4-(5-cyanothiophen-2-yl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；The protein solution contained 7 mg/ml GluR2-S1S2J, 10mM (S)-Glu, 10mM HEPES (pH 7.5), 20mM NaCl and 1mM EDTA. Compound was added to a final concentration of 150micromolar from a 30mM DMSO stock. To this solution, an equal amount of reservoir solution containing 10% PEG 8000, 0.1 M ZnAc and 0.1M NaAc, pH 5.5 was added, and 2microlitre drops of this mixture were allowed to equilibrate by vapor diffusion over a 1mL reservoir. Crystals appeared in the drops in 3-5 days.
|
Resolution 1.89 Å R-free 0.197 |
| 4YMA Structure of the ligand-binding domain of GluA2 in complex with the antagonist CNG10109 Deposited 2015-03-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Not recorded | SO4 SULFATE ION × 6 GOL GLYCEROL × 2 4E5 (3R)-3-(3-carboxy-5-hydroxyphenyl)-L-proline × 2 EDO 1,2-ETHANEDIOL × 2 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；PEG4000, lithium sulfate, phosphate citrate
|
Resolution 1.90 Å R-free 0.228 |
| 4YU0 Crystal structure of a tetramer of GluA2 TR mutant ligand binding domains bound with glutamate at 1.26 Angstrom resolution Deposited 2015-03-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Chain A
653–796（144 aa）
|
Mutation：E713T, Y768R,E713T, Y768R Mutation：E713T, Y768R,E713T, Y768R | GLU GLUTAMIC ACID × 1 PO4 PHOSPHATE ION × 3 PEG DI(HYDROXYETHYL)ETHER × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277.14 K；20% w/v PEG3350 and 200 mM (NH4)2HPO4
|
Resolution 1.26 Å R-free 0.157 |
| 4YU0 Crystal structure of a tetramer of GluA2 TR mutant ligand binding domains bound with glutamate at 1.26 Angstrom resolution Deposited 2015-03-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
413–527（115 aa）
Chain B
653–796（144 aa）
|
Mutation：E713T, Y768R,E713T, Y768R Mutation：E713T, Y768R,E713T, Y768R | GLU GLUTAMIC ACID × 1 PO4 PHOSPHATE ION × 3 PEG DI(HYDROXYETHYL)ETHER × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277.14 K；20% w/v PEG3350 and 200 mM (NH4)2HPO4
|
Resolution 1.26 Å R-free 0.157 |
| 4Z0I Crystal structure of a tetramer of GluA2 ligand binding domains bound with glutamate at 1.45 Angstrom resolution Deposited 2015-03-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–796（144 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 PO4 PHOSPHATE ION × 6 PG4 TETRAETHYLENE GLYCOL × 2 PEG DI(HYDROXYETHYL)ETHER × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277.14 K；20% PEG 3350 and 200 mM KNO3
|
Resolution 1.45 Å R-free 0.208 |
| 4Z0I Crystal structure of a tetramer of GluA2 ligand binding domains bound with glutamate at 1.45 Angstrom resolution Deposited 2015-03-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Chain B
653–796（144 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 PO4 PHOSPHATE ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277.14 K；20% PEG 3350 and 200 mM KNO3
|
Resolution 1.45 Å R-free 0.208 |
| 5BUU Crystal structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM-321 at 2.07 A resolution Deposited 2015-06-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：UNP residues 413-527,UNP residues 653-796
Chain A
653–796（144 aa）
Fragment：UNP residues 413-527,UNP residues 653-796
Chain B
413–527（115 aa）
Fragment：UNP residues 413-527,UNP residues 653-796
Chain B
653–796（144 aa）
Fragment：UNP residues 413-527,UNP residues 653-796
|
Mutation：L483Y, N754S,L483Y, N754S Mutation：L483Y, N754S,L483Y, N754S Mutation：L483Y, N754S,L483Y, N754S Mutation：L483Y, N754S,L483Y, N754S | 4V6 (3R)-7-chloro-2,3,4-trimethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2 GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 5 EDO 1,2-ETHANEDIOL × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；15.2 % PEG4000, 0.2 M ammonium-sulfate, 0.1 M phosphate-citrate
|
Resolution 2.07 Å R-free 0.250 |
| 5CBR Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid at 2.0A resolution Deposited 2015-07-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
|
Not recorded | 4ZK 3,4-dichloro-5-(5-hydroxypyridin-3-yl)-L-phenylalanine × 2 GOL GLYCEROL × 6 SO4 SULFATE ION × 12 ACT ACETATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；PEG4000, lithium sulfate and phosphate-citrate buffer pH 4.5
|
Resolution 2.00 Å R-free 0.238 |
| 5CBS Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid at 1.8A resolution Deposited 2015-07-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：UNP residues 413-527,UNP residues 653-797
Chain A
653–797（145 aa）
Fragment：UNP residues 413-527,UNP residues 653-797
Chain C
413–527（115 aa）
Fragment：UNP residues 413-527,UNP residues 653-797
Chain C
653–797（145 aa）
Fragment：UNP residues 413-527,UNP residues 653-797
|
Not recorded | E42 (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid × 2 SO4 SULFATE ION × 5 EDO 1,2-ETHANEDIOL × 4 GOL GLYCEROL × 3 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；PEG2000, lithium sulfate and phosphate-citrate buffer pH 4.5
|
Resolution 1.80 Å R-free 0.219 |
| 5CBS Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid at 1.8A resolution Deposited 2015-07-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Fragment：UNP residues 413-527,UNP residues 653-797
Chain B
653–797（145 aa）
Fragment：UNP residues 413-527,UNP residues 653-797
Chain D
413–527（115 aa）
Fragment：UNP residues 413-527,UNP residues 653-797
Chain D
653–797（145 aa）
Fragment：UNP residues 413-527,UNP residues 653-797
|
Not recorded | E42 (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid × 2 SO4 SULFATE ION × 5 EDO 1,2-ETHANEDIOL × 10 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；PEG2000, lithium sulfate and phosphate-citrate buffer pH 4.5
|
Resolution 1.80 Å R-free 0.219 |
| 5ELV Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504-N775) in complex with glutamate and BPAM-521 at 1.92 A resolution Deposited 2015-11-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Fragment：UNP residues, 413-527,UNP residue, 653-797
Chain A
653–797（145 aa）
Fragment：UNP residues, 413-527,UNP residue, 653-797
Chain B
413–527（115 aa）
Fragment：UNP residues, 413-527,UNP residue, 653-797
Chain B
653–797（145 aa）
Fragment：UNP residues, 413-527,UNP residue, 653-797
|
Mutation：L504Y and N775S Mutation：L504Y and N775S Mutation：L504Y and N775S Mutation：L504Y and N775S | SO4 SULFATE ION × 4 GOL GLYCEROL × 4 CL CHLORIDE ION × 3 ACT ACETATE ION × 9 5PX 4-Cyclopropyl-3,4-dihydro-7-hydroxy-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2 GLU GLUTAMIC ACID × 2 PEG DI(HYDROXYETHYL)ETHER × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；20% PEG4000, 0.3 M lithium sulfate and 0.1 M phosphate-citrate
|
Resolution 1.92 Å R-free 0.209 |
| 5FHM Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-(aminomethyl)benzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at resolution 1.55 A resolution Deposited 2015-12-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Not recorded | SO4 SULFATE ION × 6 5XP (2~{S})-3-[5-[2-[[3-(aminomethyl)phenyl]methyl]-1,2,3,4-tetrazol-5-yl]-3-oxidanyl-1,2-oxazol-4-yl]-2-azanyl-propanoic acid × 1 GOL GLYCEROL × 2 ACT ACETATE ION × 4 EDO 1,2-ETHANEDIOL × 7 LI LITHIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；280 K；PEG4000
lithium sulfate
sodium acetate buffer pH 5.5
|
Resolution 1.55 Å R-free 0.159 |
| 5FHN Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-methylbenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 1.6 A resolution Deposited 2015-12-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
|
Not recorded | SO4 SULFATE ION × 1 GOL GLYCEROL × 2 ACT ACETATE ION × 1 5XO (S)-2-Amino-3-(5-(2-(3-methylbenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid × 1 EDO 1,2-ETHANEDIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；18% PEG4000
0.1 M ammonium sulfate
0.1 M phosphate-citrate buffer pH 4.5
|
Resolution 1.60 Å R-free 0.186 |
| 5FHO Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-chlorobenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 2.3 A resolution Deposited 2015-12-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain D
413–527（115 aa）
Chain D
653–797（145 aa）
|
Not recorded | 5XN (1S)-1-carboxy-2-(5-{2-[(3-chlorophenyl)methyl]-2H-tetrazol-5-yl}-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)ethan-1-aminium × 2 SO4 SULFATE ION × 6 GOL GLYCEROL × 2 CL CHLORIDE ION × 5 EDO 1,2-ETHANEDIOL × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；280 K；PEG4000
ammonium sulfate
acetate buffer pH 5.5
|
Resolution 2.30 Å R-free 0.216 |
| 5FHO Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-chlorobenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 2.3 A resolution Deposited 2015-12-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
Chain C
413–527（115 aa）
Chain C
653–797（145 aa）
|
Not recorded | 5XN (1S)-1-carboxy-2-(5-{2-[(3-chlorophenyl)methyl]-2H-tetrazol-5-yl}-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)ethan-1-aminium × 2 SO4 SULFATE ION × 6 GOL GLYCEROL × 4 CL CHLORIDE ION × 4 EDO 1,2-ETHANEDIOL × 6 PG4 TETRAETHYLENE GLYCOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；280 K；PEG4000
ammonium sulfate
acetate buffer pH 5.5
|
Resolution 2.30 Å R-free 0.216 |
| 5FTH Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (zinc form) Deposited 2016-01-13 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
404–527（124 aa）
Fragment：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796
Chain B
404–527（124 aa）
Fragment：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；15% PEG 8,000, 200 MM ZN ACETATE, 100MM MES PH 6.0
|
Resolution 2.90 Å R-free 0.283 |
| 5FTH Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (zinc form) Deposited 2016-01-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
404–527（124 aa）
Fragment：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796
Chain C
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796
|
Mutation：YES Mutation：YES | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；15% PEG 8,000, 200 MM ZN ACETATE, 100MM MES PH 6.0
|
Resolution 2.90 Å R-free 0.283 |
| 5FTI Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (lithium form) Deposited 2016-01-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
404–527（124 aa）
Fragment：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796
Chain A
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796
|
Mutation：YES Mutation：YES | GLU GLUTAMIC ACID × 2 LI LITHIUM ION × 2 SO4 SULFATE ION × 4 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；22% PEG 4,000, 200 MM LI SULPHATE, 100MM ACETATE PH 5.0
|
Resolution 1.35 Å R-free 0.177 |
| 5FTI Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (lithium form) Deposited 2016-01-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
404–527（124 aa）
Fragment：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796
Chain B
653–796（144 aa）
Fragment：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796
|
Mutation：YES Mutation：YES | GLU GLUTAMIC ACID × 2 LI LITHIUM ION × 2 SO4 SULFATE ION × 4 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；22% PEG 4,000, 200 MM LI SULPHATE, 100MM ACETATE PH 5.0
|
Resolution 1.35 Å R-free 0.177 |
| 5FWX Crystal structure of the AMPA receptor GluA2/A4 N-terminal domain heterodimer Deposited 2016-02-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
25–400（376 aa）
Fragment：RESIDUES 25-400
|
Not recorded | SO4 SULFATE ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
17% PEG 3350 WITH 0.1-0.35 M AMMONIUM SULPHATE
|
Resolution 2.50 Å R-free 0.238 |
| 5FWX Crystal structure of the AMPA receptor GluA2/A4 N-terminal domain heterodimer Deposited 2016-02-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
25–400（376 aa）
Fragment：RESIDUES 25-400
|
Not recorded | SO4 SULFATE ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
17% PEG 3350 WITH 0.1-0.35 M AMMONIUM SULPHATE
|
Resolution 2.50 Å R-free 0.238 |
| 5FWY Crystal structure of the AMPA receptor GluA2/A3 N-terminal domain heterodimer Deposited 2016-02-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
25–400（376 aa）
Fragment：RESIDUES 25-400
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 SO4 SULFATE ION × 5 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
14-16 % PEG 3350, 0.27 M AMMONIUM SULPHATE AND 0.1 M BICINE PH 9
|
Resolution 2.12 Å R-free 0.231 |
| 5FWY Crystal structure of the AMPA receptor GluA2/A3 N-terminal domain heterodimer Deposited 2016-02-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
25–400（376 aa）
Fragment：RESIDUES 25-400
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
14-16 % PEG 3350, 0.27 M AMMONIUM SULPHATE AND 0.1 M BICINE PH 9
|
Resolution 2.12 Å R-free 0.231 |
| 5IDE Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model I) Deposited 2016-02-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
23–883（861 aa）
Chain C
23–883（861 aa）
|
Mutation：N292C Mutation：N292C | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；25 mM Tris pH 7.4, 0.25 % DDM, 150 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE；Incubated for 1 minute, blotted for 3 seconds
|
Resolution 8.25 Å |
| 5IDF Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model II) Deposited 2016-02-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
23–883（861 aa）
Chain C
23–883（861 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；25 mM Tris pH 7.4, 0.25 % DDM, 150 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE；Incubated for 1 minute, blotted for 3 seconds
|
Resolution 10.31 Å |
| 5JEI Crystal structure of the GluA2 LBD in complex with FW Deposited 2016-04-18 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
|
Mutation：V154C,V154C Mutation：V154C,V154C | FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 4 PO4 PHOSPHATE ION × 8 PG4 TETRAETHYLENE GLYCOL × 8 PEG DI(HYDROXYETHYL)ETHER × 12 TOE 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL × 4 PG0 2-(2-METHOXYETHOXY)ETHANOL × 4 ETE 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL × 8 EDO 1,2-ETHANEDIOL × 4 NA SODIUM ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.2；277 K；50.0 % v/v PEG 200, 200 mM Sodium Chloride, 100 mM Sodium/Potassium Phosphate pH 6.2
|
Resolution 1.23 Å R-free 0.147 |
| 5KBS Cryo-EM structure of GluA2-0xSTZ at 8.7 Angstrom resolution Deposited 2016-06-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Mutation：N241E, V382L, G384E, N385D, V758L,N241E, V382L, G384E, N385D, V758L Mutation：N241E, V382L, G384E, N385D, V758L,N241E, V382L, G384E, N385D, V758L Mutation：N241E, V382L, G384E, N385D, V758L,N241E, V382L, G384E, N385D, V758L Mutation：N241E, V382L, G384E, N385D, V758L,N241E, V382L, G384E, N385D, V758L | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3 blot force, 8.0 s blot time
|
Resolution 8.70 Å |
| 5KBT Cryo-EM structure of GluA2-1xSTZ complex at 6.4 Angstrom resolution Deposited 2016-06-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Mutation：N241E, V382L, G384E, N385D, V758L Mutation：N241E, V382L, G384E, N385D, V758L Mutation：N241E, V382L, G384E, N385D, V758L Mutation：N241E, V382L, G384E, N385D, V758L | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3 blot force, 8.0 s blot time
|
Resolution 6.40 Å |
| 5KBU Cryo-EM structure of GluA2-2xSTZ complex at 7.8 Angstrom resolution Deposited 2016-06-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Mutation：N241E, V382L, G384E, N385D, V758L Mutation：N241E, V382L, G384E, N385D, V758L Mutation：N241E, V382L, G384E, N385D, V758L Mutation：N241E, V382L, G384E, N385D, V758L | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3 blot force, 8.0 s blot time
|
Resolution 7.80 Å |
| 5KBV Cryo-EM structure of GluA2 bound to antagonist ZK200775 at 6.8 Angstrom resolution Deposited 2016-06-03 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Mutation：N241E, V382L,G384E, N385D, V758L Mutation：N241E, V382L,G384E, N385D, V758L Mutation：N241E, V382L,G384E, N385D, V758L Mutation：N241E, V382L,G384E, N385D, V758L | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；Blot force 3, 8.0 s blot time
|
Resolution 6.80 Å |
| 5KK2 Architecture of fully occupied GluA2 AMPA receptor - TARP complex elucidated by single particle cryo-electron microscopy Deposited 2016-06-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 7.30 Å |
| 5L1B AMPA subtype ionotropic glutamate receptor GluA2 in Apo state Deposited 2016-07-28 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain A
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain B
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain B
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain C
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain C
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain D
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain D
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；8-11% (w/v) PEG 8,000, 0.2 M magnesium acetate and 0.1 M sodium cacodylate (pH 6.3-6.7)
|
Resolution 4.00 Å R-free 0.292 |
| 5L1E AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor CP465022 Deposited 2016-07-29 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain A
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain B
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain B
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain C
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain C
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain D
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain D
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 6ZQ 3-(2-chlorophenyl)-2-(2-{6-[(diethylamino)methyl]pyridin-2-yl}ethyl)-6-fluoroquinazolin-4(3H)-one × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；11-14% (w/v) PEG 6,000, 0.1 M ammonium phosphate and 0.1 M TRIS (pH 7.9-8.0)
|
Resolution 4.37 Å R-free 0.292 |
| 5L1F AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor Perampanel Deposited 2016-07-29 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain A
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain B
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain B
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain C
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain C
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain D
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain D
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 6ZP 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；11-14% (w/v) PEG 6,000, 0.1 M ammonium phosphate and 0.1 M TRIS (pH 7.9-8.0)
|
Resolution 4.00 Å R-free 0.272 |
| 5L1G AMPA subtype ionotropic glutamate receptor GluA2 in complex with GYKI-Br Deposited 2016-07-29 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain A
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain B
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain B
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain C
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain C
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain D
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain D
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 GYB (8R)-5-(4-amino-3-bromophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；sodium acetate
|
Resolution 4.51 Å R-free 0.295 |
| 5L1H AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor GYKI53655 Deposited 2016-07-29 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain A
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain B
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain B
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain C
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain C
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain D
25–565（541 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
Chain D
588–847（260 aa）
Fragment：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 GYK (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；11-14% (w/v) PEG 6,000, 0.1 M ammonium phosphate and 0.1 M TRIS (pH 7.9-8.0)
|
Resolution 3.80 Å R-free 0.292 |
| 5N6P AMPA receptor NTD mutant Deposited 2017-02-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
25–400（376 aa）
|
Mutation：K73C D134C | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；16-20% PEG3350, 200 mM sodium formate
|
Resolution 2.80 Å R-free 0.249 |
| 5NG9 Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist CIP-AS at 1.15 A resolution. Deposited 2017-03-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
|
Not recorded | FLC CITRATE ANION × 4 LI LITHIUM ION × 2 8VN (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid × 2 8WQ (2~{S},3~{R},4~{R})-3-(carboxycarbonyl)-4-oxidanyl-pyrrolidine-2-carboxylic acid × 2 SO4 SULFATE ION × 6 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；15.2% PEG4000, 0.1 M lithium sulfate, 0.1 M phosphate-citrate buffer
|
Resolution 1.15 Å R-free 0.133 |
| 5NIH Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist LM-12b at 1.3 A resolution. Deposited 2017-03-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
|
Not recorded | SO4 SULFATE ION × 3 8VE (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid × 1 GOL GLYCEROL × 3 CL CHLORIDE ION × 1 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；24.4% PEG4000, 0.3 M ammonium sulfate, 0.1 M phosphate-citrate buffer
|
Resolution 1.30 Å R-free 0.158 |
| 5NIH Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist LM-12b at 1.3 A resolution. Deposited 2017-03-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Not recorded | SO4 SULFATE ION × 2 8VE (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid × 1 GOL GLYCEROL × 1 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；24.4% PEG4000, 0.3 M ammonium sulfate, 0.1 M phosphate-citrate buffer
|
Resolution 1.30 Å R-free 0.158 |
| 5NS9 Crystal structure of the GluA2 LBD (L483Y-N754S-L758V) in complex with glutamate Deposited 2017-04-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Not recorded | 1PE PENTAETHYLENE GLYCOL × 2 PG0 2-(2-METHOXYETHOXY)ETHANOL × 1 SO4 SULFATE ION × 6 NA SODIUM ION × 5 GLU GLUTAMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；277.15 K；20% w/v PEG3350, 200mM Li2SO4
|
Resolution 1.44 Å R-free 0.205 |
| 5O9A Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504Y-N775S) in complex with glutamate and BPAM121 at 1.78 A resolution Deposited 2017-06-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Mutation：L504Y,N775S Mutation：L504Y,N775S Mutation：L504Y,N775S Mutation：L504Y,N775S | SO4 SULFATE ION × 6 7M6 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide × 2 CL CHLORIDE ION × 4 GOL GLYCEROL × 3 GLU GLUTAMIC ACID × 2 EDO 1,2-ETHANEDIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；18% PEG4000, 0.23 M lithium sulfate, 0.1 M phosphate citrate pH 4.5
|
Resolution 1.78 Å R-free 0.179 |
| 5O9A Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504Y-N775S) in complex with glutamate and BPAM121 at 1.78 A resolution Deposited 2017-06-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
413–527（115 aa）
Chain C
653–797（145 aa）
Chain D
413–527（115 aa）
Chain D
653–797（145 aa）
|
Mutation：L504Y,N775S Mutation：L504Y,N775S Mutation：L504Y,N775S Mutation：L504Y,N775S | SO4 SULFATE ION × 10 7M6 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide × 2 CL CHLORIDE ION × 3 GOL GLYCEROL × 1 GLU GLUTAMIC ACID × 2 CIT CITRIC ACID × 1 PEG DI(HYDROXYETHYL)ETHER × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；18% PEG4000, 0.23 M lithium sulfate, 0.1 M phosphate citrate pH 4.5
|
Resolution 1.78 Å R-free 0.179 |
| 5OEW Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with glutamate and positive allosteric modulator BPAM538 Deposited 2017-07-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 9 ACT ACETATE ION × 2 9TE 4-cyclopropyl-7-(3-methoxyphenoxy)-2,3-dihydro-1$l^{6},2,4-benzothiadiazine 1,1-dioxide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；18% PEG4000, 0.23M lithium-sulfate, 0.1M phosphate-citrate
|
Resolution 2.00 Å R-free 0.189 |
| 5OEW Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with glutamate and positive allosteric modulator BPAM538 Deposited 2017-07-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
413–527（115 aa）
Chain C
653–797（145 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 16 ACT ACETATE ION × 4 9TE 4-cyclopropyl-7-(3-methoxyphenoxy)-2,3-dihydro-1$l^{6},2,4-benzothiadiazine 1,1-dioxide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；18% PEG4000, 0.23M lithium-sulfate, 0.1M phosphate-citrate
|
Resolution 2.00 Å R-free 0.189 |
| 5VHW GluA2-0xGSG1L bound to ZK Deposited 2017-04-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 7.80 Å |
| 5VHX GluA2-1xGSG1L bound to ZK Deposited 2017-04-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
Chain E
25–847（823 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 8.30 Å |
| 5VHY GluA2-2xGSG1L bound to ZK Deposited 2017-04-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
Chain E
25–847（823 aa）
Chain F
25–847（823 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.60 Å |
| 5VHZ GluA2-2xGSG1L bound to L-Quisqualate Deposited 2017-04-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
Chain E
25–847（823 aa）
Chain F
25–847（823 aa）
|
Not recorded | QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 8.40 Å |
| 5VOT Structure of AMPA receptor-TARP complex Deposited 2017-05-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.90 Å |
| 5VOU Structure of AMPA receptor-TARP complex Deposited 2017-05-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 6.40 Å |
| 5VOV Structure of AMPA receptor-TARP complex Deposited 2017-05-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 7.70 Å |
| 5WEK GluA2 bound to antagonist ZK and GSG1L in digitonin, state 1 Deposited 2017-07-10 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Fragment：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG
Chain B
25–847（823 aa）
Fragment：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG
Chain C
25–847（823 aa）
Fragment：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG
Chain D
25–847（823 aa）
Fragment：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG
|
Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.60 Å |
| 5WEL GluA2 bound to antagonist ZK and GSG1L in digitonin, state 2 Deposited 2017-07-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Fragment：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG
Chain B
25–847（823 aa）
Fragment：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG
Chain C
25–847（823 aa）
Fragment：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG
Chain D
25–847（823 aa）
Fragment：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG
|
Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 AJP Digitonin × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.40 Å |
| 5WEM GluA2 bound to GSG1L in digitonin, state 1 Deposited 2017-07-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Fragment：UNP P19491 residues 25-847 and UNP D3Z7H4 residues 2-238 linked via LINKER GTG
Chain B
25–847（823 aa）
Fragment：UNP P19491 residues 25-847 and UNP D3Z7H4 residues 2-238 linked via LINKER GTG
Chain C
25–847（823 aa）
Fragment：UNP P19491 residues 25-847 and UNP D3Z7H4 residues 2-238 linked via LINKER GTG
Chain D
25–847（823 aa）
Fragment：UNP P19491 residues 25-847 and UNP D3Z7H4 residues 2-238 linked via LINKER GTG
|
Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 6.10 Å |
| 5WEN GluA2 bound to GSG1L in digitonin, state 2 Deposited 2017-07-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Fragment：UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG,UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG
Chain B
25–847（823 aa）
Fragment：UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG,UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG
Chain C
25–847（823 aa）
Fragment：UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG,UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG
Chain D
25–847（823 aa）
Fragment：UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG,UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG
|
Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L,N241E, V382L, G384E, N385D, N392Q, V1151L Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L,N241E, V382L, G384E, N385D, N392Q, V1151L Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L,N241E, V382L, G384E, N385D, N392Q, V1151L Mutation：N241E, V382L, G384E, N385D, N392Q, V1151L,N241E, V382L, G384E, N385D, N392Q, V1151L | AJP Digitonin × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 6.80 Å |
| 5WEO Activated GluA2 complex bound to glutamate, cyclothiazide, and STZ in digitonin Deposited 2017-07-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Fragment：UNP P19491 residues 25-847, UNP O88602 2-208 linked via LINKER GT
Chain B
25–847（823 aa）
Fragment：UNP P19491 residues 25-847, UNP O88602 2-208 linked via LINKER GT
Chain C
25–847（823 aa）
Fragment：UNP P19491 residues 25-847, UNP O88602 2-208 linked via LINKER GT
Chain D
25–847（823 aa）
Fragment：UNP P19491 residues 25-847, UNP O88602 2-208 linked via LINKER GT
|
Mutation：N241E, V382L, G384E, N385D, V758L Mutation：N241E, V382L, G384E, N385D, V758L Mutation：N241E, V382L, G384E, N385D, V758L Mutation：N241E, V382L, G384E, N385D, V758L | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.20 Å |
| 6DLZ Open state GluA2 in complex with STZ after micelle signal subtraction Deposited 2018-06-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.90 Å |
| 6DM0 Open state GluA2 in complex with STZ and blocked by IEM-1460, after micelle signal subtraction Deposited 2018-06-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 GZD N,N,N-trimethyl-5-({[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]methyl}amino)pentan-1-aminium × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.40 Å |
| 6DM1 Open state GluA2 in complex with STZ and blocked by NASPM, after micelle signal subtraction Deposited 2018-06-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 GYY N-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]-2-(naphthalen-1-yl)acetamide × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.20 Å |
| 6FAZ Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the positive allosteric modulator TDPAM01 at 1.4 A resolution. Deposited 2017-12-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Not recorded | SO4 SULFATE ION × 5 PEG DI(HYDROXYETHYL)ETHER × 2 GOL GLYCEROL × 5 CL CHLORIDE ION × 5 ACT ACETATE ION × 3 GLU GLUTAMIC ACID × 2 EDO 1,2-ETHANEDIOL × 2 D45 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；15% PEG4000, 0.3 M ammonium sulfate, 0.1 M phosphate-citrate
|
Resolution 1.40 Å R-free 0.168 |
| 6FQG GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form A) at 2.34 Angstrom resolution Deposited 2018-02-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Mutation：S729C Mutation：S729C Mutation：S729C Mutation：S729C | GLU GLUTAMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；287 K；0.2M Ammonium chloride, 20% PEG 3350, 10uM ZK200775
|
Resolution 2.34 Å R-free 0.231 |
| 6FQH GluA2(flop) S729C ligand binding core dimer bound to NBQX at 1.76 Angstrom resolution Deposited 2018-02-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
400–527（128 aa）
Chain A
653–797（145 aa）
Chain B
400–527（128 aa）
Chain B
653–797（145 aa）
|
Mutation：S729C,S729C Mutation：S729C,S729C Mutation：S729C,S729C Mutation：S729C,S729C | E2Q 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；289 K；0.1M tri-sodium Citrate, 20% PEG 3000
|
Resolution 1.76 Å R-free 0.224 |
| 6FQI GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form B) at 2.91 Angstrom resolution Deposited 2018-02-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；289 K；0.16 M Calcium acetate, 0.08 M Sodium Cacodylate, 14.4% (w/v) PEG 8000, 20% (v/v) Glycerol, 1 mM glutamate
|
Resolution 2.91 Å R-free 0.267 |
| 6FQJ GluA2(flop) G724C ligand binding core dimer bound to ZK200775 at 2.50 Angstrom resolution Deposited 2018-02-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain H
413–527（115 aa）
Chain H
653–797（145 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；287 K；0.2M Ammonium Chloride, 20% PEG 3350, 10microM ZK200775.
|
Resolution 2.50 Å R-free 0.265 |
| 6FQJ GluA2(flop) G724C ligand binding core dimer bound to ZK200775 at 2.50 Angstrom resolution Deposited 2018-02-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
Chain G
413–527（115 aa）
Chain G
653–797（145 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；287 K；0.2M Ammonium Chloride, 20% PEG 3350, 10microM ZK200775.
|
Resolution 2.50 Å R-free 0.265 |
| 6FQJ GluA2(flop) G724C ligand binding core dimer bound to ZK200775 at 2.50 Angstrom resolution Deposited 2018-02-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
413–527（115 aa）
Chain C
653–797（145 aa）
Chain E
413–527（115 aa）
Chain E
653–797（145 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；287 K；0.2M Ammonium Chloride, 20% PEG 3350, 10microM ZK200775.
|
Resolution 2.50 Å R-free 0.265 |
| 6FQJ GluA2(flop) G724C ligand binding core dimer bound to ZK200775 at 2.50 Angstrom resolution Deposited 2018-02-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
413–527（115 aa）
Chain D
653–797（145 aa）
Chain F
413–527（115 aa）
Chain F
653–797（145 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；287 K；0.2M Ammonium Chloride, 20% PEG 3350, 10microM ZK200775.
|
Resolution 2.50 Å R-free 0.265 |
| 6FQK GluA2(flop) S729C ligand binding core dimer bound to ZK200775 at 1.98 Angstrom resolution Deposited 2018-02-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
400–527（128 aa）
Chain A
653–797（145 aa）
Chain B
400–527（128 aa）
Chain B
653–797（145 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；287 K；0.2M Ammonium Chloride, 20% PEG 3350, 10microM ZK200775.
|
Resolution 1.98 Å R-free 0.256 |
| 6GIV Structure of GluA2-N775S ligand-binding domain (S1S2J) in complex with glutamate and Rubidium Bromide at 1.75 A resolution Deposited 2018-05-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
|
Mutation：N775S,N775S Mutation：N775S,N775S | GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 2 GOL GLYCEROL × 6 BR BROMIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；18-24.4% PEG4000, 0.2-0.3 M Li2SO4, and 0.1 M cacodylate, pH 6.5
|
Resolution 1.75 Å R-free 0.190 |
| 6GL4 Structure of GluA2o ligand-binding domain (S1S2J) in complex with glutamate and sodium bromide at 1.95 A resolution Deposited 2018-05-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
652–797（146 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 BR BROMIDE ION × 6 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；25% PEG4000, 0.2M sodium sulfate, 0.1M sodium acetate pH 5.5
|
Resolution 1.95 Å R-free 0.199 |
| 6GL4 Structure of GluA2o ligand-binding domain (S1S2J) in complex with glutamate and sodium bromide at 1.95 A resolution Deposited 2018-05-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Chain B
652–797（146 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 BR BROMIDE ION × 6 NA SODIUM ION × 4 ACT ACETATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；25% PEG4000, 0.2M sodium sulfate, 0.1M sodium acetate pH 5.5
|
Resolution 1.95 Å R-free 0.199 |
| 6HC9 STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-L504Y-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM02 AT 2.4 A RESOLUTION. Deposited 2018-08-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Not recorded | GOL GLYCEROL × 1 CL CHLORIDE ION × 7 GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 8 PEG DI(HYDROXYETHYL)ETHER × 3 PGE TRIETHYLENE GLYCOL × 1 FXW 6,6'-(ETHANE-1,2-DIYL)BIS(4-CYCLOPROPYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE) × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；291 K；20% PEG4000, 0.3 M lithium sulfate, 0.1 M phosphate citrate
|
Resolution 2.40 Å R-free 0.239 |
| 6HCA STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S1J) IN COMPLEX WITH POSITIVE ALLOSTERIC MODULATOR TDPAM02 AT 1.8 A RESOLUTION Deposited 2018-08-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Not recorded | SO4 SULFATE ION × 10 GOL GLYCEROL × 7 CL CHLORIDE ION × 6 FXW 6,6'-(ETHANE-1,2-DIYL)BIS(4-CYCLOPROPYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE) × 1 PEG DI(HYDROXYETHYL)ETHER × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；291 K；24% PEG4000, 0.3 M lithium sulfate, 0.1 M phosphate citrate
|
Resolution 1.88 Å R-free 0.207 |
| 6HCB STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.9 A RESOLUTION. Deposited 2018-08-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Not recorded | SO4 SULFATE ION × 9 GLU GLUTAMIC ACID × 2 GOL GLYCEROL × 4 CL CHLORIDE ION × 4 PEG DI(HYDROXYETHYL)ETHER × 2 D45 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；15% PEG4000, 0.1 M ammonium sulphate, 0.1 M phosphate citrate
|
Resolution 1.90 Å R-free 0.192 |
| 6HCC STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM02 AT 1.6 A RESOLUTION. Deposited 2018-08-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Not recorded | FXW 6,6'-(ETHANE-1,2-DIYL)BIS(4-CYCLOPROPYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE) × 1 GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 5 GOL GLYCEROL × 7 PEG DI(HYDROXYETHYL)ETHER × 2 CL CHLORIDE ION × 3 ACT ACETATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；291 K；24% PEG4000, 0.3 M lithium sulfate, 0.1 M phosphate citrate
|
Resolution 1.62 Å R-free 0.182 |
| 6HCH STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-L504Y-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.6 A RESOLUTION. Deposited 2018-08-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 15 D45 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) × 1 ACT ACETATE ION × 5 GOL GLYCEROL × 1 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；15% PEG4000, 0.1 M zinc acetate, 0.1 M sodium acetate
|
Resolution 1.60 Å R-free 0.178 |
| 6HCH STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-L504Y-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.6 A RESOLUTION. Deposited 2018-08-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
413–527（115 aa）
Chain C
653–797（145 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 16 D45 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) × 2 ACT ACETATE ION × 6 GOL GLYCEROL × 2 CL CHLORIDE ION × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；15% PEG4000, 0.1 M zinc acetate, 0.1 M sodium acetate
|
Resolution 1.60 Å R-free 0.178 |
| 6NJL Architecture and subunit arrangement of native AMPA receptors Deposited 2019-01-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 14 PDB declaration: tetradecameric |
Chain B
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 6.70 Å |
| 6NJM Architecture and subunit arrangement of native AMPA receptors Deposited 2019-01-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 16 PDB declaration: hexadecameric |
Chain B
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 6.50 Å |
| 6NJN Architecture and subunit arrangement of native AMPA receptors Deposited 2019-01-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 15 PDB declaration: pentadecameric |
Chain B
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 6.50 Å |
| 6O9G Open state GluA2 in complex with STZ and blocked by AgTx-636, after micelle signal subtraction Deposited 2019-03-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 LU7 N~1~-{5-[(3-{[3-(L-arginylamino)propyl]amino}propyl)amino]pentyl}-N~2~-[(2,4-dihydroxyphenyl)acetyl]-L-aspartamide × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.80 Å |
| 6PEQ GluA2 in complex with its auxiliary subunit CNIH3 - map LBD-TMD-C3 - with antagonist ZK200775 -without NTD Deposited 2019-06-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–868（868 aa）
Chain B
1–868（868 aa）
Chain C
1–868（868 aa）
Chain D
1–868（868 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 8 PAM PALMITOLEIC ACID × 14 CLR CHOLESTEROL × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.97 Å |
| 6Q54 Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(1-ethyl-4-hydroxy-1H-1,2,3-triazol-5-yl)propanoic acid at 1.4 A resolution Deposited 2018-12-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Not recorded | SO4 SULFATE ION × 10 HJ8 (2~{S})-2-azanyl-3-(3-ethyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid × 2 GOL GLYCEROL × 4 PGE TRIETHYLENE GLYCOL × 2 CL CHLORIDE ION × 3 CIT CITRIC ACID × 1 LI LITHIUM ION × 3 PEG DI(HYDROXYETHYL)ETHER × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；20% PEG4000, 0.3 M lithium sulfate, 0.1 M phosphate-citrate
|
Resolution 1.40 Å R-free 0.163 |
| 6Q60 Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(2-methyl-5-hydroxy-2H-1,2,3-triazol-4-yl)propanoic acid at 1.55 A resolution Deposited 2018-12-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Not recorded | HJH (2~{S})-2-azanyl-3-(2-methyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid × 2 SO4 SULFATE ION × 4 GOL GLYCEROL × 12 CL CHLORIDE ION × 3 LI LITHIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；10% PEG4000, 0.1 M lithium sulfate, 0.1 M phosphate-citrate, pH 4.5
|
Resolution 1.55 Å R-free 0.175 |
| 6QKC GluA1/2 In complex with auxiliary subunit gamma-8 Deposited 2019-01-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain B
1–860（860 aa）
Chain D
1–860（860 aa）
|
Not recorded | E2Q 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 12 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；25 mM TRIS, pH 8, 150 mM NaCl and 0.1 % digitonin (w/v)
cryo-EM vitrification conditions
Cryogen ETHANE；3uL on grid, 60 sec incubation and 4sec blotting time
|
Resolution 4.40 Å |
| 6QKZ Full length GluA1/2-gamma8 complex Deposited 2019-01-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain B
22–860（839 aa）
Chain D
22–860（839 aa）
|
Not recorded | E2Q 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；25 mM TRIS, pH 8, 150 mM NaCl and 0.1 % digitonin (w/v)
cryo-EM vitrification conditions
Cryogen ETHANE；3uL on grid, 60 sec incubation and 4sec blotting time
|
Resolution 6.30 Å |
| 6RUQ Structure of GluA2cryst in complex the antagonist ZK200775 and the negative allosteric modulator GYKI53655 at 4.65 A resolution Deposited 2019-05-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Mutation：N235E, N385D, N392Q, K410A, R586Q, C589A Mutation：N235E, N385D, N392Q, K410A, R586Q, C589A Mutation：N235E, N385D, N392Q, K410A, R586Q, C589A Mutation：N235E, N385D, N392Q, K410A, R586Q, C589A | GYK (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide × 4 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6；279 K；0.1 M MES, 12 % PEG 20,000
|
Resolution 4.65 Å R-free 0.291 |
| 6U5S NTD of GluA2 in complex with CNIH3 - with antagonist ZK200775 - in pseudo-symmetric global conformation Deposited 2019-08-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–868（868 aa）
Chain B
1–868（868 aa）
Chain C
1–868（868 aa）
Chain D
1–868（868 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.07 Å |
| 6U6I NTD of GluA2 in complex with CNIH3 - with antagonist ZK200775 - in asymmetric global conformation Deposited 2019-08-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–868（868 aa）
Chain B
1–868（868 aa）
Chain C
1–868（868 aa）
Chain D
1–868（868 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.12 Å |
| 6UCB GluA2 in complex with its auxiliary subunit CNIH3 - with antagonist ZK200775, LBD, TMD, CNIH3, and lipids Deposited 2019-09-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–868（868 aa）
Chain B
1–868（868 aa）
Chain C
1–868（868 aa）
Chain D
1–868（868 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 8 PAM PALMITOLEIC ACID × 14 CLR CHOLESTEROL × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.28 Å |
| 6UD4 GluA2 in complex with its auxiliary subunit CNIH3 in AS map II - (LBD-TMD-C3(AS) II)- with antagonist ZK200775, without NTD Deposited 2019-09-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–868（868 aa）
Chain B
1–868（868 aa）
Chain C
1–868（868 aa）
Chain D
1–868（868 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 CLR CHOLESTEROL × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 6UD8 GluA2 in complex with its auxiliary subunit CNIH3 - with antagonist ZK200775 Deposited 2019-09-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–868（868 aa）
Chain B
1–868（868 aa）
Chain C
1–868（868 aa）
Chain D
1–868（868 aa）
|
Not recorded | OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 CLR CHOLESTEROL × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 6XSR Crystal structure of GluA2 AMPA receptor in complex with trans-4-butylcyclohexane carboxylic acid (4-BCCA) inhibitor Deposited 2020-07-16 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–838（814 aa）
Chain B
25–838（814 aa）
Chain C
25–838（814 aa）
Chain D
25–838（814 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 V8G trans-4-butylcyclohexane-1-carboxylic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；8-11% (w/v) PEG 8,000, 0.2 M magnesium acetate and 0.1 M sodium cacodylate (pH 6.3-6.7) or 11-14% (w/v) PEG 6,000, 0.1 M ammonium phosphate and 0.1 M TRIS (pH 7.9-8.0)
|
Resolution 4.25 Å R-free 0.296 |
| 6YK2 Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno[3,4-d]pyrimidin- 2,4(1H,3H)-dione at resolution 1.60A Deposited 2020-04-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
|
Not recorded | SO4 SULFATE ION × 6 GOL GLYCEROL × 10 CGW (2~{S})-2-azanyl-3-[2,4-bis(oxidanylidene)-5,7-dihydrothieno[3,4-d]pyrimidin-1-yl]propanoic acid × 2 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；15% PEG4000, 0.3M Lithium Sulfate, 0.1M acetate
|
Resolution 1.61 Å R-free 0.163 |
| 6YK3 Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound ( S) - 1- [2'-Amino-2'-carboxyethyl]-5 ,7- dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 1.20A Deposited 2020-04-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
|
Not recorded | GOL GLYCEROL × 8 SO4 SULFATE ION × 8 PVQ (S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione × 2 NH4 AMMONIUM ION × 2 CL CHLORIDE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；20% PEG4000, 0.3M ammonium sulfate, 0.1M acetate
|
Resolution 1.20 Å R-free 0.140 |
| 6YK4 Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound ( S) - 1- [2'-Amino-2'-carboxyethyl]-6-methyl-5 ,7- dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 1.00A Deposited 2020-04-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
|
Not recorded | SO4 SULFATE ION × 8 GOL GLYCEROL × 8 LI LITHIUM ION × 2 CG8 (2~{S})-2-azanyl-3-[6-methyl-2,4-bis(oxidanylidene)-5,7-dihydropyrrolo[3,4-d]pyrimidin-1-yl]propanoic acid × 2 CL CHLORIDE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；15.2% PEG4000, 0.3M lithium sulfate, 0.1M acetate
|
Resolution 1.00 Å R-free 0.120 |
| 6YK5 Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-Amino-2'-carboxyethyl)-5,7-dihydrofuro[3,4-d]- pyrimidine-2,4(1H,3H)-dione at resolution 1.15A Deposited 2020-04-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
|
Not recorded | GOL GLYCEROL × 8 SO4 SULFATE ION × 12 LI LITHIUM ION × 2 PVK (S)-1-(2'-Amino-2'-carboxyethyl)-5,7-dihydrofuro[3,4-d]-pyrimidine-2,4(1H,3H)-dione × 2 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；PEG4000, lithium sulfate, acetate
|
Resolution 1.15 Å R-free 0.130 |
| 6YK6 Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-Amino-2'-carboxyethyl)furo[3,4-d]pyrimidin-2,4-dione at resolution 1.47A Deposited 2020-04-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
|
Not recorded | SO4 SULFATE ION × 8 GOL GLYCEROL × 6 LI LITHIUM ION × 2 CL CHLORIDE ION × 4 OUB (S)-1-(2'-Amino-2'-carboxyethyl)furo[3,4-d]pyrimidin-2,4-dione × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；24.4% PEG4000, 0.15M lithium sulfate, 0.1M phosphate-citrate
|
Resolution 1.47 Å R-free 0.172 |
| 6ZYU Structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM549 Deposited 2020-08-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
|
Mutation：L483Y,N754S Mutation：L483Y,N754S | ZN ZINC ION × 4 CAC CACODYLATE ION × 2 ACT ACETATE ION × 4 GLU GLUTAMIC ACID × 2 QSZ (4~{S})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide × 2 QSW (4~{R})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide × 2 GOL GLYCEROL × 6 CL CHLORIDE ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；299 K；Zinc acetate, polyethylene glycol 4000, cacodylate
|
Resolution 1.90 Å R-free 0.187 |
| 6ZYU Structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM549 Deposited 2020-08-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
Chain C
413–527（115 aa）
Chain C
653–797（145 aa）
|
Mutation：L483Y,N754S Mutation：L483Y,N754S Mutation：L483Y,N754S Mutation：L483Y,N754S | ZN ZINC ION × 6 ACT ACETATE ION × 3 GLU GLUTAMIC ACID × 2 QSZ (4~{S})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide × 2 QSW (4~{R})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide × 2 GOL GLYCEROL × 3 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；299 K；Zinc acetate, polyethylene glycol 4000, cacodylate
|
Resolution 1.90 Å R-free 0.187 |
| 7OCA Resting state full-length GluA1/A2 heterotertramer in complex with TARP gamma 8 and CNIH2 Deposited 2021-04-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric |
Chain B
1–860（860 aa）
Chain D
1–860（860 aa）
|
Not recorded | E2Q 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 46 CLR CHOLESTEROL × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 7OCC NTD of resting state GluA1/A2 heterotertramer Deposited 2021-04-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
1–860（860 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 7OCC NTD of resting state GluA1/A2 heterotertramer Deposited 2021-04-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
1–860（860 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 7OCD Resting state GluA1/A2 heterotetramer in complex with auxiliary subunit TARP gamma 8 (LBD-TMD) Deposited 2021-04-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain B
1–860（860 aa）
Chain D
1–860（860 aa）
|
Not recorded | E2Q 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.50 Å |
| 7OCE Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD) Deposited 2021-04-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain B
1–860（860 aa）
Chain D
1–860（860 aa）
|
Not recorded | E2Q 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 46 CLR CHOLESTEROL × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 7OCF Active state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD) Deposited 2021-04-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain B
1–860（860 aa）
Chain D
1–860（860 aa）
|
Not recorded | CYZ CYCLOTHIAZIDE × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 26 GLU GLUTAMIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.60 Å |
| 7QHB Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ Deposited 2021-12-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain B
1–860（860 aa）
Chain D
1–860（860 aa）
|
Not recorded | PAM PALMITOLEIC ACID × 14 GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 2 79N (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；25 mM TRIS
150 mM NaCl
0.02 % GDN
87 uM CTZ
100 mM L-Glu
cryo-EM vitrification conditions
Cryogen ETHANE；3-4 second blots
|
Resolution 3.50 Å |
| 7QHH Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD) Deposited 2021-12-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain B
1–860（860 aa）
Chain D
1–860（860 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 PAM PALMITOLEIC ACID × 10 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 2 79N (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；25 mM TRIS
150 mM NaCl
0.02 % GDN
87 uM CTZ
100 mM L-Glu
cryo-EM vitrification conditions
Cryogen ETHANE；3-4 second blots
|
Resolution 3.60 Å |
| 7RYY Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist glutamate Deposited 2021-08-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GLU GLUTAMIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；25 mM glutamate was added to the purified protein and incubated on ice for 30 min before sample preparation
|
Resolution 4.40 Å |
| 7RYZ Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit GSG1L bound to agonist quisqualate Deposited 2021-08-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；1mM Quisqualate was added to the purified protein and incubated on ice for 30 min before sample preparation
|
Resolution 4.15 Å |
| 7RZ4 Structure of the complex of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK 200775 Deposited 2021-08-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 24 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；0.1mM ZK was added to the purified protein and incubated on ice for 30 min before sample preparation
|
Resolution 3.60 Å |
| 7RZ5 Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK 200775 Deposited 2021-08-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 24 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；0.1mM ZK was added to the purified protein and incubated on ice for 30 min before sample preparation
|
Resolution 3.30 Å |
| 7RZ6 Structure of the complex of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist glutamate Deposited 2021-08-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GLU GLUTAMIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；25 mM glutamate was added to the purified protein and incubated on ice for 30 min before sample preparation
|
Resolution 4.40 Å |
| 7RZ7 Structure of the complex of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist Quisqualate Deposited 2021-08-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；1 mM Quisqualate was added to the purified protein and incubated on ice for 30 min before sample preparation
|
Resolution 4.20 Å |
| 7RZ8 Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist quisqualate Deposited 2021-08-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 22 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；1 mM Quisqualate was added to the purified protein and incubated on ice for 30 min before sample preparation
|
Resolution 4.10 Å |
| 7RZ9 Structure of the complex of AMPA receptor GluA2 with auxiliary subunit GSG1L in the apo state Deposited 2021-08-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.15 Å |
| 7RZA Structure of the complex of AMPA receptor GluA2 with auxiliary subunit GSG1L bound to agonist quisqualate Deposited 2021-08-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；1mM Quisqualate was added to the purified protein and incubated on ice for 30 min before sample preparation
|
Resolution 4.26 Å |
| 7TNK Complex GNNN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM) Deposited 2022-01-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | GLU GLUTAMIC ACID × 1 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.50 Å |
| 7TNL Complex GNGN1 of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM) Deposited 2022-01-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.59 Å |
| 7TNM Complex GNGN2 of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM) Deposited 2022-01-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.74 Å |
| 7TNN Complex GGNN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM) Deposited 2022-01-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | GLU GLUTAMIC ACID × 2 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.91 Å |
| 7TNO Complex GGGN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM) Deposited 2022-01-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | GLU GLUTAMIC ACID × 3 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.02 Å |
| 7TNP Complex GGGG of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM) Deposited 2022-01-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.96 Å |
| 8AYL Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059 Deposited 2022-09-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain B
1–860（860 aa）
Chain D
1–860（860 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 PLM PALMITIC ACID × 8 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 6 OIJ 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 8AYM Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118 Deposited 2022-09-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain B
1–860（860 aa）
Chain D
1–860（860 aa）
|
Not recorded | XVD 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol × 2 PLM PALMITIC ACID × 14 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 6 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 8AYN Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand LY3130481 Deposited 2022-09-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain B
1–860（860 aa）
Chain D
1–860（860 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 PLM PALMITIC ACID × 14 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 4 OLR 6-[(1~{S})-1-[1-[5-(2-hydroxyethyloxy)pyridin-2-yl]pyrazol-3-yl]ethyl]-3~{H}-1,3-benzothiazol-2-one × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 8AYO Open state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059 Deposited 2022-09-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain B
1–860（860 aa）
Chain D
1–860（860 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 PLM PALMITIC ACID × 10 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 2 OIJ 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 8C1R Resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma-2 Deposited 2022-12-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PLM PALMITIC ACID × 7 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 5 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 8C1S Transmembrane domain of resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma 2 Deposited 2022-12-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | PLM PALMITIC ACID × 6 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 8FP4 GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 500mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na610) Deposited 2023-01-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain B
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain C
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain D
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
|
Not recorded | CL CHLORIDE ION × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.40 Å |
| 8FP9 GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg) Deposited 2023-01-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion | CA CALCIUM ION × 1 CL CHLORIDE ION × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100 mM) and cyclothiazide (CTZ, 0.33 mM) were added before freezing. The 1 M L-glutamic acid stock solution was adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.44 Å |
| 8FPC Conformation 1 of the ligand binding domain (LBDconf1) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg) Deposited 2023-01-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100 mM) and cyclothiazide (CTZ, 0.33 mM) were added before freezing. The 1 M L-glutamic acid stock solution was adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.78 Å |
| 8FPG GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg) Deposited 2023-01-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion | CL CHLORIDE ION × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 0.1 mM) and cyclothiazide (CTZ, 0.33 mM) were added before freezing.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.32 Å |
| 8FPH Conformation 2 of the ligand binding domain (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg) Deposited 2023-01-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100 mM) and cyclothiazide (CTZ, 330 uM) were added before freezing. The 1 M L-glutamic acid stock solution was adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.14 Å |
| 8FPK LBD conformation 1 of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg) Deposited 2023-01-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion | Y4Y 6-(aminomethyl)-7-nitro-1,4-dihydroquinoxaline-2,3-dione × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 0.1 mM) and cyclothiazide (CTZ, 0.33 mM) were added before freezing.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.76 Å |
| 8FPL LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg) Deposited 2023-01-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion Mutation：FLAG epitope tag (DYKDDDDK) insertion | Y4Y 6-(aminomethyl)-7-nitro-1,4-dihydroquinoxaline-2,3-dione × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, final conc. 0.1mM) and cyclothiazide (CTZ, final conc. 0.33mM) was added before freezing.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.81 Å |
| 8FPS GluA2 flip Q isoform N619K mutant of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg/N619K) Deposited 2023-01-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain B
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain C
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain D
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
|
Mutation：N619K Mutation：N619K Mutation：N619K Mutation：N619K | CL CHLORIDE ION × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.38 Å |
| 8FPV LBD conformation 1 (LBDconf1) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 500mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na610) Deposited 2023-01-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.08 Å |
| 8FPY LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 500mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na610) Deposited 2023-01-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.98 Å |
| 8FPZ LBD conformation 3 (LBDconf3) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 500mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na610) Deposited 2023-01-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.01 Å |
| 8FQ1 GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 150mM CaCl2, 330uM CTZ, and 100mM L-glutamate (Open-Ca150) Deposited 2023-01-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain B
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain C
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain D
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CA CALCIUM ION × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 5.59 Å |
| 8FQ2 LBD conformation 1 (LBDconf1) of GluA2 flip Q isoform N619K mutant of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg/N619K) Deposited 2023-01-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain B
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain C
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain D
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
|
Mutation：N619K Mutation：N619K Mutation：N619K Mutation：N619K | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.14 Å |
| 8FQ3 LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform N619K mutant of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg/N619K) Deposited 2023-01-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain B
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain C
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain D
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
|
Mutation：N619K Mutation：N619K Mutation：N619K Mutation：N619K | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.17 Å |
| 8FQ5 GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Na110) Deposited 2023-01-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | CL CHLORIDE ION × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.34 Å |
| 8FQ6 LBD of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 150mM CaCl2, 330uM CTZ, and 100mM L-glutamate (Open-Ca150) Deposited 2023-01-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain B
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain C
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain D
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.14 Å |
| 8FQ8 LBD conformation 1 (LBDconf1) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Na110) Deposited 2023-01-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) were added before freezing. The 1 M L-glutamic acid stock solution was adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.11 Å |
| 8FQA LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Na110) Deposited 2023-01-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.35 Å |
| 8FQB GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 10mM CaCl2, 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Ca10) Deposited 2023-01-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain B
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain C
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
Chain D
1–883（883 aa）
Fragment：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification
|
Not recorded | CA CALCIUM ION × 1 CL CHLORIDE ION × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.36 Å |
| 8FQD LBD conformation 1 (LBDconf1) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 10mM CaCl2, 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Ca10) Deposited 2023-01-06 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.01 Å |
| 8FQE LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 10mM CaCl2, 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Ca10) Deposited 2023-01-06 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.14 Å |
| 8FQF GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 150mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na260) Deposited 2023-01-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | CL CHLORIDE ION × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.29 Å |
| 8FQG LBD conformation 1 (LBDconf1) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 150mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na260) Deposited 2023-01-06 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.01 Å |
| 8FQH LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 150mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na260) Deposited 2023-01-06 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.43 Å |
| 8FR0 LBD conformation 3 (LBDconf3) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 150mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na260) Deposited 2023-01-06 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.04 Å |
| 8P3Q Homomeric GluA2 flip R/G-unedited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 3 Deposited 2023-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | PLM PALMITIC ACID × 7 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 5 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.95 Å |
| 8P3S Homomeric GluA2 flip R/G-unedited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 2 Deposited 2023-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | PLM PALMITIC ACID × 7 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 5 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.95 Å |
| 8P3X Homomeric GluA2 flip R/G-edited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 1 Deposited 2023-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Mutation：F231A Mutation：F231A Mutation：F231A Mutation：F231A | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.36 Å |
| 8P3Y Homomeric GluA2 flip R/G-edited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 3 Deposited 2023-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Mutation：F231A Mutation：F231A Mutation：F231A Mutation：F231A | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.55 Å |
| 8P3Z Homomeric GluA2 flip R/G-edited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 2 Deposited 2023-05-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Mutation：F231A Mutation：F231A Mutation：F231A Mutation：F231A | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.46 Å |
| 8QEZ Crystal structure of the AMPA receptor GluA2-L504Y-N775S ligand binding domain in complex with L-glutamate and positive allosteric modulator BPAM395 at 1.55A resolution Deposited 2023-09-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
413–527（115 aa）
Chain A
653–797（145 aa）
Chain B
413–527（115 aa）
Chain B
653–797（145 aa）
|
Mutation：L504Y,N775S Mutation：L504Y,N775S Mutation：L504Y,N775S Mutation：L504Y,N775S | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 5 ACT ACETATE ION × 7 UF5 6-chloranyl-4-cyclopropyl-2,3-dihydrothieno[3,2-e][1,2,4]thiadiazine 1,1-dioxide × 2 CL CHLORIDE ION × 2 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；15.2% PEG4000, 0.1M Zn Acetate, 0.1M Cacodylate pH 6.5
|
Resolution 1.55 Å R-free 0.195 |
| 8QEZ Crystal structure of the AMPA receptor GluA2-L504Y-N775S ligand binding domain in complex with L-glutamate and positive allosteric modulator BPAM395 at 1.55A resolution Deposited 2023-09-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
413–527（115 aa）
Chain C
653–797（145 aa）
|
Mutation：L504Y,N775S Mutation：L504Y,N775S | GLU GLUTAMIC ACID × 2 ZN ZINC ION × 4 ACT ACETATE ION × 2 UF5 6-chloranyl-4-cyclopropyl-2,3-dihydrothieno[3,2-e][1,2,4]thiadiazine 1,1-dioxide × 2 CL CHLORIDE ION × 2 GOL GLYCEROL × 6 CAC CACODYLATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；15.2% PEG4000, 0.1M Zn Acetate, 0.1M Cacodylate pH 6.5
|
Resolution 1.55 Å R-free 0.195 |
| 8SS2 Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state) Deposited 2023-05-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 26 CLR CHOLESTEROL × 2 AJP Digitonin × 2 SPD SPERMIDINE × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；vitrification carried out in nitrogen atmosphere
|
Resolution 3.58 Å |
| 8SS3 Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state) Deposited 2023-05-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 50 CLR CHOLESTEROL × 4 AJP Digitonin × 6 SPD SPERMIDINE × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；vitrification carried out in nitrogen atmosphere
|
Resolution 3.21 Å |
| 8SS4 Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 (apo state) Deposited 2023-05-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | SPD SPERMIDINE × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；vitrification carried out in nitrogen atmosphere
|
Resolution 3.30 Å |
| 8SS5 Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 (apo state) Deposited 2023-05-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | NA SODIUM ION × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；vitrification carried out in nitrogen atmosphere
|
Resolution 3.56 Å |
| 8SS6 Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK, channel blocker spermidine and antiepileptic drug perampanel (closed state) Deposited 2023-05-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | 6ZP 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile × 4 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 28 CLR CHOLESTEROL × 8 NA SODIUM ION × 1 SPD SPERMIDINE × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；vitrification carried out in nitrogen atmosphere
|
Resolution 3.01 Å |
| 8SS7 Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK, channel blocker spermidine and antiepileptic drug perampanel (closed state) Deposited 2023-05-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | 6ZP 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile × 4 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 28 CLR CHOLESTEROL × 8 NA SODIUM ION × 1 SPD SPERMIDINE × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；vitrification carried out in nitrogen atmosphere
|
Resolution 2.76 Å |
| 8SS8 Structure of AMPA receptor GluA2 complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state) Deposited 2023-05-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | 6ZP 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile × 4 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 NA SODIUM ION × 2 CLR CHOLESTEROL × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；vitrification carried out in nitrogen atmosphere
|
Resolution 2.81 Å |
| 8SS9 Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state) Deposited 2023-05-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | 6ZP 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile × 4 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 CLR CHOLESTEROL × 2 NA SODIUM ION × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；vitrification carried out in nitrogen atmosphere
|
Resolution 2.72 Å |
| 8SSA Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to glutamate and channel blocker spermidine (desensitized state) Deposited 2023-05-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 GLU GLUTAMIC ACID × 4 SPD SPERMIDINE × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；vitrification carried out in nitrogen atmosphere
|
Resolution 3.88 Å |
| 8SSB Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to glutamate and channel blocker spermidine (desensitized state) Deposited 2023-05-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 28 GLU GLUTAMIC ACID × 4 SPD SPERMIDINE × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；vitrification carried out in nitrogen atmosphere
|
Resolution 3.66 Å |
| 8VJ6 GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 1 Deposited 2024-01-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–842（818 aa）
Chain B
25–842（818 aa）
Chain C
25–842（818 aa）
Chain D
25–842（818 aa）
|
Not recorded | A1AB5 4-[(5S,8R)-8-methyl-6,7,8,9-tetrahydro-2H,5H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.50 Å |
| 8VJ7 GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 2 Deposited 2024-01-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–842（818 aa）
Chain B
25–842（818 aa）
Chain C
25–842（818 aa）
Chain D
25–842（818 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 A1AB5 4-[(5S,8R)-8-methyl-6,7,8,9-tetrahydro-2H,5H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.85 Å |
| 9B5Z GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of LBD-TMD-TARPgamma2 Deposited 2024-03-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；Tris adjusted to pH 8 using HCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.71 Å |
| 9B60 GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of TMD-TARPgamma2 Deposited 2024-03-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；Tris adjusted to pH 8 using HCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.57 Å |
| 9B61 GluA2 flip Q in complex with TARPgamma2 at pH5, consensus structure of LBD-TMD-TARPgamma2 Deposited 2024-03-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；Tris adjusted to pH 8 using HCl.
4 micro litter of protein in buffer was mixed with 1 micro litter of 50mM citric acid buffer (the 50mM citric acid buffer was prepared by diluting 0.5M citric acid/sodium citrate buffer at pH4.0) immediately before applying the sample to the grid.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.81 Å |
| 9B63 GluA2 flip Q in complex with TARPgamma2 at pH5, consensus structure of TMD-TARPgamma2 Deposited 2024-03-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；Tris adjusted to pH 8 using HCl.
4 micro litter of protein in buffer was mixed with 1 micro litter of 50mM citric acid buffer (the 50mM citric acid buffer was prepared by diluting 0.5M citric acid/sodium citrate buffer at pH4.0) immediately before applying the sample to the grid.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.76 Å |
| 9B64 GluA2 flip Q in complex with TARPgamma2 at pH5, class23, structure of LBD-TMD-TARPgamma2 Deposited 2024-03-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；Tris adjusted to pH 8 using HCl.
4 micro litter of protein in buffer was mixed with 1 micro litter of 50mM citric acid buffer (the 50mM citric acid buffer was prepared by diluting 0.5M citric acid/sodium citrate buffer at pH4.0) immediately before applying the sample to the grid.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.56 Å |
| 9B67 GluA2 flip Q in complex with TARPgamma2 at pH8, class1, structure of LBD-TMD-TARPgamma2 Deposited 2024-03-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；Tris adjusted to pH 8 using HCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.39 Å |
| 9B68 GluA2 flip Q in complex with TARPgamma2 at pH8, class1, structure of NTD Deposited 2024-03-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；Tris adjusted to pH 8 using HCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.60 Å |
| 9B69 GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of NTD Deposited 2024-03-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；Tris adjusted to pH 8 using HCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.69 Å |
| 9B6A GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of LBD-TMD-TARPgamma2 Deposited 2024-03-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–883（883 aa）
Chain B
1–883（883 aa）
Chain C
1–883（883 aa）
Chain D
1–883（883 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；Tris adjusted to pH 8 using HCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.35 Å |
| 9DHP Resting state 1 of the GluA2-gamma2 complex Deposited 2024-09-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
412–841（430 aa）
Chain B
412–841（430 aa）
Chain C
412–841（430 aa）
Chain D
412–841（430 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.18 Å |
| 9DHQ Resting state 2 of the GluA2-gamma2 complex Deposited 2024-09-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
412–841（430 aa）
Chain B
412–841（430 aa）
Chain C
412–841（430 aa）
Chain D
412–841（430 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.78 Å |
| 9DHR Glutamate activated state of the GluA2-gamma2 complex Deposited 2024-09-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
412–841（430 aa）
Chain B
412–841（430 aa）
Chain C
412–841（430 aa）
Chain D
412–841（430 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.54 Å |
| 9DHS Desensitized state 1 of the GluA2-gamma2 complex Deposited 2024-09-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
412–841（430 aa）
Chain B
412–841（430 aa）
Chain C
412–841（430 aa）
Chain D
412–841（430 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.48 Å |
| 9DHT Desensitized state 2 of the GluA2-gamma2 complex Deposited 2024-09-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
412–841（430 aa）
Chain B
412–841（430 aa）
Chain C
412–841（430 aa）
Chain D
412–841（430 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.31 Å |
| 9E4Y GluA2-gamma2 complex bound to memantine, glutamate, and cyclothiazide Deposited 2024-10-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
25–841（817 aa）
Chain B
25–841（817 aa）
Chain C
25–841（817 aa）
Chain D
25–841（817 aa）
|
Not recorded | 377 Memantine × 1 GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.30 Å |
| 9E4Z GluA2-gamma2 complex bound glutamate and cyclothiazide Deposited 2024-10-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
25–841（817 aa）
Chain B
25–841（817 aa）
Chain C
25–841（817 aa）
Chain D
25–841（817 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.70 Å |
| 9E9D Structure of full length AMPA receptor GluA2 and auxiliary subunit TARP gamma-2 in complex with anti-miR 17 oligonucleotide RGLS4326 Deposited 2024-11-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Not recorded | A1BX3 O-{[(1S,3S,4R,6S,7R)-7-{[(R)-{[(1R,3R,4R,6S,7R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-1-yl]methoxy}(sulfanyl)phosphoryl]oxy}-3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-1-yl]methyl} O-[(2R,3S,4R,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxy-2-methyloxolan-3-yl] hydrogen (R)-phosphorothioate × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.24 Å |
| 9E9E Structure of AMPA receptor GluA2 and auxiliary subunit TARP gamma-2 (LBD-TMD) in complex with anti-miR 17 oligonucleotide RGLS4326 Deposited 2024-11-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
25–847（823 aa）
Chain B
25–847（823 aa）
Chain C
25–847（823 aa）
Chain D
25–847（823 aa）
|
Mutation：N48D Mutation：N48D Mutation：N48D Mutation：N48D | A1BX3 O-{[(1S,3S,4R,6S,7R)-7-{[(R)-{[(1R,3R,4R,6S,7R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-1-yl]methoxy}(sulfanyl)phosphoryl]oxy}-3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-1-yl]methyl} O-[(2R,3S,4R,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxy-2-methyloxolan-3-yl] hydrogen (R)-phosphorothioate × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.24 Å |
| 9MRK Glutamate activated state of the GluA2-gamma2 complex prepared at 37 degrees C Deposited 2025-01-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
412–841（430 aa）
Chain B
412–841（430 aa）
Chain C
412–841（430 aa）
Chain D
412–841（430 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.62 Å |
| 9MRL Desensitized state 1 of the GluA2-gamma2 complex prepared at 37 degrees C Deposited 2025-01-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
412–841（430 aa）
Chain B
412–841（430 aa）
Chain C
412–841（430 aa）
Chain D
412–841（430 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.17 Å |
| 9MRM Desensitized state 2 of the GluA2-gamma2 complex prepared at 37 degrees C Deposited 2025-01-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
412–841（430 aa）
Chain B
412–841（430 aa）
Chain C
412–841（430 aa）
Chain D
412–841（430 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.52 Å |
| 9MRN Consensus glutamate activated state of the GluA2-gamma2 complex Deposited 2025-01-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
412–841（430 aa）
Chain B
412–841（430 aa）
Chain C
412–841（430 aa）
Chain D
412–841（430 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.46 Å |
| 9OVT Heteromeric GluA1/A2 in the inactive state, composite map of LBD-TMD Deposited 2025-05-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain B
413–841（429 aa）
Chain D
413–841（429 aa）
|
Not recorded | ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NA SODIUM ION × 3 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；150 mM NaCl, 20 mM Tris-HCl pH 8.0, and 0.05% digitonin, 100 uM ZK-200775
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.43 Å |
| 9OVU Composite map of GluA1/A2 in the activated state, in complex with positive allosteric modulator (R,R)-2b and agonist glutamate (ATD-LBD-TMD) Deposited 2025-05-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain B
1–847（847 aa）
Chain D
1–847（847 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 NA SODIUM ION × 1 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；150 mM NaCl, 20 mM Tris-HCl pH 8.0, and 0.05% digitonin, 500 uM (R,R)-2b, 1 mM glutamate
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9OVV Heteromeric GluA1/A2-CNIH1 in the activated state, composite map of LBD-TMD Deposited 2025-05-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain B
413–840（428 aa）
Chain D
413–840（428 aa）
|
Not recorded | GLU GLUTAMIC ACID × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 16 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2 NA SODIUM ION × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；150 mM NaCl, 20 mM Tris-HCl pH 8.0, and 0.05% digitonin, 500 uM (R,R)-2b, 1 mM glutamate
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.76 Å |
| 9OVW Heteromeric GluA1/A2 in the desensitized state, composite map of ATD-LBD-TMD Deposited 2025-05-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain B
25–841（817 aa）
Chain D
25–841（817 aa）
|
Not recorded | QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；150 mM NaCl, 20 mM Tris-HCl pH 8.0, and 0.05% digitonin, 1 mM quiqualate
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.91 Å |
333 other PDB entries and 482 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | GRIA2_RAT |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–826； UniProt 22–847 Author chain B； PDBConstruct 1–826； UniProt 22–847 Author chain C； PDBConstruct 1–826； UniProt 22–847 Author chain D； PDBConstruct 1–826； UniProt 22–847 |
