5adx

CryoEM structure of dynactin complex at 4.0 angstrom resolution

Method: ELECTRON MICROSCOPY
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

ACTIN RELATED PROTEIN 1

物种未注明

UniProt F2Z5G5

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 27 ACTIN, CYTOPLASMIC 1 × 1 (Q6QAQ1) ACTIN RELATED PROTEIN 11 × 1 (I3LHK5) CAPPING PROTEIN (ACTIN FILAMENT) MUSCLE Z-LINE, ALPHA 1 × 1 (A0PFK5) F-ACTIN CAPPING PROTEIN BETA SUBUNIT VARIANT II × 1 (D2JYW4) DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 3 × 2 DYNACTIN SUBUNIT 2 × 2 DYNACTIN 5 × 1 (D0G6S1) DYNACTIN SUBUNIT 6 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 2 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 F2Z5G5_PIG
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–370; UniProt 7–376 作者链 B; PDB构建体 1–370; UniProt 7–376 作者链 C; PDB构建体 1–370; UniProt 7–376 作者链 D; PDB构建体 1–370; UniProt 7–376 作者链 E; PDB构建体 1–370; UniProt 7–376 作者链 F; PDB构建体 1–370; UniProt 7–376 作者链 G; PDB构建体 1–370; UniProt 7–376 作者链 I; PDB构建体 1–370; UniProt 7–376

ACTIN, CYTOPLASMIC 1

物种未注明

UniProt Q6QAQ1

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 27 ACTIN RELATED PROTEIN 1 × 8 (F2Z5G5) ACTIN RELATED PROTEIN 11 × 1 (I3LHK5) CAPPING PROTEIN (ACTIN FILAMENT) MUSCLE Z-LINE, ALPHA 1 × 1 (A0PFK5) F-ACTIN CAPPING PROTEIN BETA SUBUNIT VARIANT II × 1 (D2JYW4) DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 3 × 2 DYNACTIN SUBUNIT 2 × 2 DYNACTIN 5 × 1 (D0G6S1) DYNACTIN SUBUNIT 6 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 2 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ACTB_PIG
Isoform —
PDB实体 2
链与序列区间 作者链 H; PDB构建体 1–370; UniProt 6–375

ACTIN RELATED PROTEIN 11

物种未注明

UniProt I3LHK5

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 27 ACTIN RELATED PROTEIN 1 × 8 (F2Z5G5) ACTIN, CYTOPLASMIC 1 × 1 (Q6QAQ1) CAPPING PROTEIN (ACTIN FILAMENT) MUSCLE Z-LINE, ALPHA 1 × 1 (A0PFK5) F-ACTIN CAPPING PROTEIN BETA SUBUNIT VARIANT II × 1 (D2JYW4) DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 3 × 2 DYNACTIN SUBUNIT 2 × 2 DYNACTIN 5 × 1 (D0G6S1) DYNACTIN SUBUNIT 6 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 2 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 I3LHK5_PIG
Isoform —
PDB实体 3
链与序列区间 作者链 J; PDB构建体 1–417; UniProt 1–417

CAPPING PROTEIN (ACTIN FILAMENT) MUSCLE Z-LINE, ALPHA 1

物种未注明

UniProt A0PFK5

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 27 ACTIN RELATED PROTEIN 1 × 8 (F2Z5G5) ACTIN, CYTOPLASMIC 1 × 1 (Q6QAQ1) ACTIN RELATED PROTEIN 11 × 1 (I3LHK5) F-ACTIN CAPPING PROTEIN BETA SUBUNIT VARIANT II × 1 (D2JYW4) DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 3 × 2 DYNACTIN SUBUNIT 2 × 2 DYNACTIN 5 × 1 (D0G6S1) DYNACTIN SUBUNIT 6 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 2 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 A0PFK5_PIG
Isoform —
PDB实体 4
链与序列区间 作者链 K; PDB构建体 1–275; UniProt 7–281

F-ACTIN CAPPING PROTEIN BETA SUBUNIT VARIANT II

物种未注明

UniProt D2JYW4

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 27 ACTIN RELATED PROTEIN 1 × 8 (F2Z5G5) ACTIN, CYTOPLASMIC 1 × 1 (Q6QAQ1) ACTIN RELATED PROTEIN 11 × 1 (I3LHK5) CAPPING PROTEIN (ACTIN FILAMENT) MUSCLE Z-LINE, ALPHA 1 × 1 (A0PFK5) DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 3 × 2 DYNACTIN SUBUNIT 2 × 2 DYNACTIN 5 × 1 (D0G6S1) DYNACTIN SUBUNIT 6 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 2 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 D2JYW4_PIG
Isoform —
PDB实体 5
链与序列区间 作者链 L; PDB构建体 1–270; UniProt 2–271

DYNACTIN 5

物种未注明

UniProt D0G6S1

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 27 ACTIN RELATED PROTEIN 1 × 8 (F2Z5G5) ACTIN, CYTOPLASMIC 1 × 1 (Q6QAQ1) ACTIN RELATED PROTEIN 11 × 1 (I3LHK5) CAPPING PROTEIN (ACTIN FILAMENT) MUSCLE Z-LINE, ALPHA 1 × 1 (A0PFK5) F-ACTIN CAPPING PROTEIN BETA SUBUNIT VARIANT II × 1 (D2JYW4) DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 3 × 2 DYNACTIN SUBUNIT 2 × 2 DYNACTIN SUBUNIT 6 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 2 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 DYNACTIN SUBUNIT 2 × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 D0G6S1_PIG
Isoform —
PDB实体 10
链与序列区间 作者链 U; PDB构建体 1–189; UniProt 1–190

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id5adx
沉积日期 deposition_date2015-08-24
结构标题 titleCryoEM structure of dynactin complex at 4.0 angstrom resolution
关键词 keywordsSTRUCTURAL PROTEIN, DYNEIN CO-FACTOR, ACTIN-LIKE FILAMENT, CELLULAR CARGO TRANSPORT; STRUCTURAL PROTEIN
实验方法 methodELECTRON MICROSCOPY
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

5adx__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

5adx__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

5adx__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)98.41 Å
Rg(电子密度)99.99 Å
总 Rg99.28 Å
原子数49392
残基数7306
排除体积858580 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 5adx__assembly_1__model_1 27-meric (27) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (17)

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6. 折叠分类 (SCOP + CATH) 34 domains

CATH v4.4 (34 domains)

结构域编号 domain_id5adxA01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxA02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxA03
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology640 — Actin; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
结构域编号 domain_id5adxB01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxB02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxB03
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology640 — Actin; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
结构域编号 domain_id5adxC01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxC02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxC03
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology640 — Actin; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
结构域编号 domain_id5adxD01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxD02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxD03
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology640 — Actin; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
结构域编号 domain_id5adxE01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxE02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxE03
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology640 — Actin; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
结构域编号 domain_id5adxF01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxF02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxF03
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology640 — Actin; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
结构域编号 domain_id5adxG01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxG02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxG03
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology640 — Actin; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
结构域编号 domain_id5adxH01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxH02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxH03
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology640 — Actin; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
结构域编号 domain_id5adxI01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxI02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id5adxI03
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology640 — Actin; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
结构域编号 domain_id5adxJ01
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology640 — Actin; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
结构域编号 domain_id5adxK01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1140 — Ribosomal protein S3 C-terminal domain
同源超家族 H-superfamily homologous superfamily60 — F-actin capping protein, alpha subunit
结构域编号 domain_id5adxK02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology1150 — Aspartate Aminotransferase, domain 1
同源超家族 H-superfamily homologous superfamily210 — F-actin capping protein, beta subunit
结构域编号 domain_id5adxL01
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily570 — F-actin capping protein, alpha/beta subunit, N-terminal domain
结构域编号 domain_id5adxL02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology1150 — Aspartate Aminotransferase, domain 1
同源超家族 H-superfamily homologous superfamily210 — F-actin capping protein, beta subunit
结构域编号 domain_id5adxU00
类 Class class2 — Mainly Beta
架构 Architecture architecture160 — 3 Solenoid
拓扑 Topology topology10 — UDP N-Acetylglucosamine Acyltransferase; domain 1
同源超家族 H-superfamily homologous superfamily10 — Hexapeptide repeat proteins
结构域编号 domain_id5adxV00
类 Class class2 — Mainly Beta
架构 Architecture architecture160 — 3 Solenoid
拓扑 Topology topology10 — UDP N-Acetylglucosamine Acyltransferase; domain 1
同源超家族 H-superfamily homologous superfamily10 — Hexapeptide repeat proteins
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7. 引用文献 (1)