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7r5j

Human nuclear pore complex (dilated)

Method: ELECTRON MICROSCOPY Dmax: 786.2 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

E3 SUMO-protein ligase RanBP2

OrganismNot specified

UniProt P49792

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain 00； UniProt 1–3224 Chain 01； UniProt 1–3224 Chain 02； UniProt 1–3224 Chain 03； UniProt 1–3224 Chain 04； UniProt 1–3224 Not recorded Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1RRP STRUCTURE OF THE RAN-GPPNHP-RANBD1 COMPLEX Deposited 1999-01-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1171–1304（134 aa）
Not recorded MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.25；pH 6.25
Resolution 2.96 Å R-free 0.304
1RRP STRUCTURE OF THE RAN-GPPNHP-RANBD1 COMPLEX Deposited 1999-01-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1171–1304（134 aa）
Not recorded MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.25；pH 6.25
Resolution 2.96 Å R-free 0.304
1RRP STRUCTURE OF THE RAN-GPPNHP-RANBD1 COMPLEX Deposited 1999-01-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1171–1304（134 aa）
Chain D 1171–1304（134 aa）
Not recorded MG MAGNESIUM ION × 4 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.25；pH 6.25
Resolution 2.96 Å R-free 0.304
1RRP STRUCTURE OF THE RAN-GPPNHP-RANBD1 COMPLEX Deposited 1999-01-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1171–1304（134 aa）
Chain D 1171–1304（134 aa）
Not recorded MG MAGNESIUM ION × 2 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.25；pH 6.25
Resolution 2.96 Å R-free 0.304
1XKE Solution structure of the second Ran-binding domain from human RanBP2 Deposited 2004-09-28 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2028–2154（127 aa） Fragment：Ran-binding domain 2 (RanBD2)
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；298 K；Ionic strength (raw mmCIF value) 150 mM Na2SO4；Pressure ambient
NMR sample composition 1.4mM RanBD2 U-13C; U-15N; 150mM Na2SO4; 10mM DTE; 0.5 mM EDTA; 1mM NaN3; 0.1mM DSS; 10mM potassium phosphate buffer at pH 6.5; | 92% H2O, 8%D2O
NMR sample composition 0.7mM RanBD2 U-13C; U-15N; 150mM Na2SO4; 10mM DTE; 0.5mM EDTA; 1mM NaN3; 0.1mM DSS; 10mM potassium phosphate buffer at pH 6.5; | 100% D2O
NMR sample composition 1.0mM RanBD2 U-15N; 150mM Na2SO4; 10mM DTE; 0.5mM EDTA; 1mM NaN3; 0.1 mM DSS; 10mM potassium phosphate buffer at pH 6.5; | 92% H2O, 8%D2O
NMR sample composition 1.0mM RanBD2 U-15N; 150mM Na2SO4; 10mM DTE; 0.5mM EDTA; 1mM NaN3; 0.1mM DSS; 10mM potassium phosphate buffer at pH 6.5; | 100% D2O
Resolution not provided
1Z5S Crystal structure of a complex between UBC9, SUMO-1, RANGAP1 and NUP358/RANBP2 Deposited 2005-03-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 2631–2711（81 aa） Fragment：IR1-M domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；18% PEG4000 (w/v), 0.1 M sodium citrate, 0.2 M ammonium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
Resolution 3.01 Å R-free 0.290
3UIN Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2 Deposited 2011-11-05 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 2629–2695（67 aa） Fragment：UNP residues 2629-2695
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；279 K；100 mM HEPES pH 7.5, 400 mM ammonium citrate, 2% isopropanol, VAPOR DIFFUSION, HANGING DROP, temperature 279K
Resolution 2.60 Å R-free 0.264
3UIO Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2 containing IR2 Motif II Deposited 2011-11-05 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 2631–2695（65 aa） Fragment：UNP residues 2631-2695
Mutation：A2642V, Q2644E, L2647K, T2649D, K2650T Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；279 K；14% PEG4000, 100 mM sodium citrate pH 6.0, 200 mM ammonium acetate, vapor diffusion, hanging drop, temperature 279K
Resolution 2.60 Å R-free 0.251
3UIP Complex between human RanGAP1-SUMO1, UBC9 and the IR1 domain from RanBP2 containing IR2 Motif II Deposited 2011-11-05 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 2631–2695（65 aa） Fragment：UNP residues 2631-2695
Mutation：A2642V, Q2644E, L2647K, T2649D, K2650T Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；279 K；22% PEG4000, 100 mM HEPES pH 7.5, 400 mM ammonium citrate, 2% isopropanol, VAPOR DIFFUSION, HANGING DROP, temperature 279K
Resolution 2.29 Å R-free 0.232
4GA0 Structure of the N-terminal domain of Nup358 Deposited 2012-07-24 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–145（145 aa） Fragment：unp residues 1-145
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；18 % (w/v) PEG 3350 200 mM lithium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 1.15 Å R-free 0.239
4I9Y Structure of the C-terminal domain of Nup358 Deposited 2012-12-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 3062–3224（163 aa）
Not recorded GOL GLYCEROL × 3 CL CHLORIDE ION × 1 TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.3；294 K；0.1 M TRIS-HCL, 0.2 M NaCl, 0.9 M K/Na Tartrate, pH 8.3, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 1.75 Å R-free 0.158
4I9Y Structure of the C-terminal domain of Nup358 Deposited 2012-12-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 3062–3224（163 aa）
Not recorded GOL GLYCEROL × 5 CL CHLORIDE ION × 1 TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.3；294 K；0.1 M TRIS-HCL, 0.2 M NaCl, 0.9 M K/Na Tartrate, pH 8.3, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 1.75 Å R-free 0.158
4I9Y Structure of the C-terminal domain of Nup358 Deposited 2012-12-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 3062–3224（163 aa）
Not recorded GOL GLYCEROL × 3 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.3；294 K；0.1 M TRIS-HCL, 0.2 M NaCl, 0.9 M K/Na Tartrate, pH 8.3, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 1.75 Å R-free 0.158
4I9Y Structure of the C-terminal domain of Nup358 Deposited 2012-12-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain D 3062–3224（163 aa）
Not recorded GOL GLYCEROL × 5 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.3；294 K；0.1 M TRIS-HCL, 0.2 M NaCl, 0.9 M K/Na Tartrate, pH 8.3, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 1.75 Å R-free 0.158
4I9Y Structure of the C-terminal domain of Nup358 Deposited 2012-12-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain E 3062–3224（163 aa）
Not recorded GOL GLYCEROL × 2 CL CHLORIDE ION × 1 TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.3；294 K；0.1 M TRIS-HCL, 0.2 M NaCl, 0.9 M K/Na Tartrate, pH 8.3, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 1.75 Å R-free 0.158
4I9Y Structure of the C-terminal domain of Nup358 Deposited 2012-12-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain F 3062–3224（163 aa）
Not recorded GOL GLYCEROL × 3 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.3；294 K；0.1 M TRIS-HCL, 0.2 M NaCl, 0.9 M K/Na Tartrate, pH 8.3, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 1.75 Å R-free 0.158
4L6E Crystal Structure of the RanBD1 fourth domain of E3 SUMO-protein ligase RanBP2. Northeast Structural Genomics Consortium (NESG) Target HR9193b Deposited 2013-06-12 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2907–3050（144 aa） Fragment：RanBD1 4 domain (UNP residues 2907-3050)
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions Microbatch crystallization under oil；pH 7；277 K；12% PEG 3350, 0.1M sodium acetate, pH 7.00, Microbatch crystallization under oil, temperature 277K
Resolution 2.50 Å R-free 0.222
4LQW Crystal structure of HIV-1 capsid N-terminal domain in complex with NUP358 cyclophilin Deposited 2013-07-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 3057–3224（168 aa） Fragment：UNP Residues 3057-3224
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；290 K；23 % v/v PEG 4000, 23 % glycerol, 8.5 % isopropanol, 85 mM HEPES pH 7.5, 20 mM spermine tetrahydrochloride, 100 mM glycine, VAPOR DIFFUSION, SITTING DROP, temperature 290K
Resolution 1.95 Å R-free 0.246
4LQW Crystal structure of HIV-1 capsid N-terminal domain in complex with NUP358 cyclophilin Deposited 2013-07-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 3057–3224（168 aa） Fragment：UNP Residues 3057-3224
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；290 K；23 % v/v PEG 4000, 23 % glycerol, 8.5 % isopropanol, 85 mM HEPES pH 7.5, 20 mM spermine tetrahydrochloride, 100 mM glycine, VAPOR DIFFUSION, SITTING DROP, temperature 290K
Resolution 1.95 Å R-free 0.246
5CLL Truncated Ran wild type in complex with GDP-BeF and RanBD1 Deposited 2015-07-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1155–1321（167 aa） Fragment：Ran binding domain 1, residues 1155-1321
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 BEF BERYLLIUM TRIFLUORIDE ION × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.25；291 K；18 % PEG 4000, 250 mM ammonium sulfate, 100 mM MES pH 6.25, 1 mM BeF
Resolution 2.45 Å R-free 0.272
5CLL Truncated Ran wild type in complex with GDP-BeF and RanBD1 Deposited 2015-07-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1155–1321（167 aa） Fragment：Ran binding domain 1, residues 1155-1321
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 BEF BERYLLIUM TRIFLUORIDE ION × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.25；291 K；18 % PEG 4000, 250 mM ammonium sulfate, 100 mM MES pH 6.25, 1 mM BeF
Resolution 2.45 Å R-free 0.272
5CLQ Ran Y39A in complex with GPPNHP and RanBD1 Deposited 2015-07-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1155–1321（167 aa） Fragment：Ran binding domain 1, UNP residues 1155-1321
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；1.8M ammonium sulfate, 2.5% PEG 1500, 100 mM HEPES pH 7.5
Resolution 3.20 Å R-free 0.254
5CLQ Ran Y39A in complex with GPPNHP and RanBD1 Deposited 2015-07-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1155–1321（167 aa） Fragment：Ran binding domain 1, UNP residues 1155-1321
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；1.8M ammonium sulfate, 2.5% PEG 1500, 100 mM HEPES pH 7.5
Resolution 3.20 Å R-free 0.254
7MNJ Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 145-673) Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 145–673（529 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；294 K；1% (w/v) PEG 2,000 MME; 0.8 M succinic acid; 0.1 M HEPES
Resolution 3.80 Å R-free 0.242
7MNJ Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 145-673) Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 145–673（529 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；294 K；1% (w/v) PEG 2,000 MME; 0.8 M succinic acid; 0.1 M HEPES
Resolution 3.80 Å R-free 0.242
7MNJ Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 145-673) Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 145–673（529 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；294 K；1% (w/v) PEG 2,000 MME; 0.8 M succinic acid; 0.1 M HEPES
Resolution 3.80 Å R-free 0.242
7MNK Crystal structure of the tetramerization element of NUP358/RanBP2 (residues 805-832) Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 805–832（28 aa）
Chain B 805–832（28 aa）
Chain C 805–832（28 aa）
Chain D 805–832（28 aa）
Not recorded EDO 1,2-ETHANEDIOL × 4 SO4 SULFATE ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 3.5；294 K；2 M ammonium sulfate; 0.1 M citric acid
Resolution 1.10 Å R-free 0.167
7MNL Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) in complex with Fab fragment Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–752（752 aa）
Mutation：I599M No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.6；294 K；3% (w/v) PEG 4,000; 0.15 M sodium acetate; 0.1 M sodium citrate
Resolution 3.95 Å R-free 0.241
7MNL Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) in complex with Fab fragment Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–752（752 aa）
Mutation：I599M No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.6；294 K；3% (w/v) PEG 4,000; 0.15 M sodium acetate; 0.1 M sodium citrate
Resolution 3.95 Å R-free 0.241
7MNM Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) T585M mutant in complex with Fab fragment Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–752（752 aa）
Mutation：I599M, T585M No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；2.5 % (w/v) PEG 4,000; 0.15 M sodium acetate; 0.1 M sodium citrate
Resolution 4.70 Å R-free 0.254
7MNM Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) T585M mutant in complex with Fab fragment Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–752（752 aa）
Mutation：I599M, T585M No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；2.5 % (w/v) PEG 4,000; 0.15 M sodium acetate; 0.1 M sodium citrate
Resolution 4.70 Å R-free 0.254
7MNN Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) T653I mutant in complex with Fab fragment Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–752（752 aa）
Mutation：I599M, T653I No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；294 K；4 (w/v) % PEG 4,000; 0.15 M sodium acetate; 0.1 M sodium citrate
Resolution 6.70 Å R-free 0.263
7MNN Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) T653I mutant in complex with Fab fragment Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–752（752 aa）
Mutation：I599M, T653I No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；294 K；4 (w/v) % PEG 4,000; 0.15 M sodium acetate; 0.1 M sodium citrate
Resolution 6.70 Å R-free 0.263
7MNO Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) I656V mutant in complex with Fab fragment Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–752（752 aa）
Mutation：I599M, I656V No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.6；294 K；3.5 % (w/v) PEG 4,000; 0.15 M sodium acetate; 0.1 M sodium citrate
Resolution 6.73 Å R-free 0.254
7MNO Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) I656V mutant in complex with Fab fragment Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–752（752 aa）
Mutation：I599M, I656V No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.6；294 K；3.5 % (w/v) PEG 4,000; 0.15 M sodium acetate; 0.1 M sodium citrate
Resolution 6.73 Å R-free 0.254
7MNP Crystal Structure of the ZnF2 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1407–1443（37 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.4；294 K；17 % (w/v) PEG 3,350; 0.1M Bis-Tris
Resolution 2.05 Å R-free 0.231
7MNP Crystal Structure of the ZnF2 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1407–1443（37 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.4；294 K；17 % (w/v) PEG 3,350; 0.1M Bis-Tris
Resolution 2.05 Å R-free 0.231
7MNQ Crystal Structure of the ZnF2 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1407–1443（37 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；294 K；21% (w/v) PEG 3350; 0.1 M Bis-Tris
Resolution 2.05 Å R-free 0.208
7MNR Crystal Structure of the ZnF3 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1471–1507（37 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；294 K；19% (w/v) PEG 3350; 0.1 M Bis-Tris
Resolution 1.80 Å R-free 0.196
7MNS Crystal Structure of the ZnF4 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1535–1571（37 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；294 K；18 % (w/v) PEG 3,350; 0.1M Bis-Tris
Resolution 2.10 Å R-free 0.203
7MNT Crystal Structure of the ZnF5 or ZnF6 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1598–1634（37 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；294 K；19 % (w/v) PEG 3,350; 0.1M Bis-Tris
Resolution 2.45 Å R-free 0.257
7MNT Crystal Structure of the ZnF5 or ZnF6 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1598–1634（37 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；294 K；19 % (w/v) PEG 3,350; 0.1M Bis-Tris
Resolution 2.45 Å R-free 0.257
7MNU Crystal Structure of the ZnF7 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1716–1752（37 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；294 K；19% (w/v) PEG 3350; 0.1 M Bis-Tris
Resolution 2.00 Å R-free 0.224
7MNV Crystal Structure of the ZnF8 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1773–1809（37 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 GOL GLYCEROL × 1 MG MAGNESIUM ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.7；294 K；19% (w/v) PEG 3350; 0.1 M Bis-Tris
Resolution 1.80 Å R-free 0.185
7MNW Crystal Structure of Nup358/RanBP2 Ran-binding domain 1 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1171–1306（136 aa） Fragment：RAN-binding domain 1 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 1171-1306)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；20% w/v PEG3350, 0.2 M potassium sodium tartrate tetrahydrate
Resolution 2.40 Å R-free 0.242
7MNW Crystal Structure of Nup358/RanBP2 Ran-binding domain 1 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1171–1306（136 aa） Fragment：RAN-binding domain 1 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 1171-1306)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；20% w/v PEG3350, 0.2 M potassium sodium tartrate tetrahydrate
Resolution 2.40 Å R-free 0.242
7MNW Crystal Structure of Nup358/RanBP2 Ran-binding domain 1 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 1171–1306（136 aa） Fragment：RAN-binding domain 1 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 1171-1306)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；20% w/v PEG3350, 0.2 M potassium sodium tartrate tetrahydrate
Resolution 2.40 Å R-free 0.242
7MNW Crystal Structure of Nup358/RanBP2 Ran-binding domain 1 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1171–1306（136 aa） Fragment：RAN-binding domain 1 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 1171-1306)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；20% w/v PEG3350, 0.2 M potassium sodium tartrate tetrahydrate
Resolution 2.40 Å R-free 0.242
7MNX Crystal Structure of Nup358/RanBP2 Ran-binding domain 2 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 2012–2148（137 aa） Fragment：RAN-binding domain 2 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2012-2148)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；15% w/v PEG3350, 0.125 M magnesium formate
Resolution 2.40 Å R-free 0.230
7MNX Crystal Structure of Nup358/RanBP2 Ran-binding domain 2 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 2012–2148（137 aa） Fragment：RAN-binding domain 2 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2012-2148)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；15% w/v PEG3350, 0.125 M magnesium formate
Resolution 2.40 Å R-free 0.230
7MNX Crystal Structure of Nup358/RanBP2 Ran-binding domain 2 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 2012–2148（137 aa） Fragment：RAN-binding domain 2 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2012-2148)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；15% w/v PEG3350, 0.125 M magnesium formate
Resolution 2.40 Å R-free 0.230
7MNX Crystal Structure of Nup358/RanBP2 Ran-binding domain 2 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 2012–2148（137 aa） Fragment：RAN-binding domain 2 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2012-2148)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；15% w/v PEG3350, 0.125 M magnesium formate
Resolution 2.40 Å R-free 0.230
7MNX Crystal Structure of Nup358/RanBP2 Ran-binding domain 2 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain J 2012–2148（137 aa） Fragment：RAN-binding domain 2 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2012-2148)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；15% w/v PEG3350, 0.125 M magnesium formate
Resolution 2.40 Å R-free 0.230
7MNX Crystal Structure of Nup358/RanBP2 Ran-binding domain 2 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain L 2012–2148（137 aa） Fragment：RAN-binding domain 2 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2012-2148)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；15% w/v PEG3350, 0.125 M magnesium formate
Resolution 2.40 Å R-free 0.230
7MNY Crystal Structure of Nup358/RanBP2 Ran-binding domain 3 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 2309–2443（135 aa） Fragment：RAN-binding domain 3 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2309-2443)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；20% w/v PEG3350, 0.2 M sodium formate
Resolution 2.70 Å R-free 0.262
7MNY Crystal Structure of Nup358/RanBP2 Ran-binding domain 3 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 2309–2443（135 aa） Fragment：RAN-binding domain 3 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2309-2443)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；20% w/v PEG3350, 0.2 M sodium formate
Resolution 2.70 Å R-free 0.262
7MNY Crystal Structure of Nup358/RanBP2 Ran-binding domain 3 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 2309–2443（135 aa） Fragment：RAN-binding domain 3 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2309-2443)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；20% w/v PEG3350, 0.2 M sodium formate
Resolution 2.70 Å R-free 0.262
7MNY Crystal Structure of Nup358/RanBP2 Ran-binding domain 3 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 2309–2443（135 aa） Fragment：RAN-binding domain 3 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2309-2443)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；20% w/v PEG3350, 0.2 M sodium formate
Resolution 2.70 Å R-free 0.262
7MNY Crystal Structure of Nup358/RanBP2 Ran-binding domain 3 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain J 2309–2443（135 aa） Fragment：RAN-binding domain 3 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2309-2443)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；20% w/v PEG3350, 0.2 M sodium formate
Resolution 2.70 Å R-free 0.262
7MNY Crystal Structure of Nup358/RanBP2 Ran-binding domain 3 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain L 2309–2443（135 aa） Fragment：RAN-binding domain 3 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2309-2443)
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；20% w/v PEG3350, 0.2 M sodium formate
Resolution 2.70 Å R-free 0.262
7MNZ Crystal Structure of Nup358/RanBP2 Ran-binding domain 4 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 2911–3045（135 aa） Fragment：;RAN-binding domain 4 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2911-3045), WHTMKNYY/QNYDNKQV mutant (UNP residues 2962-2969) ;
Mutation：W2962Q, H2963N, T2964Y, M2965D, K2966N, N2967K, Y2928Q, Y2969V GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；294 K；20% w/v PEG3350, 0.1 M ammonium sulfate, 0.1 M HEPES
Resolution 2.35 Å R-free 0.225
7MNZ Crystal Structure of Nup358/RanBP2 Ran-binding domain 4 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 2911–3045（135 aa） Fragment：;RAN-binding domain 4 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2911-3045), WHTMKNYY/QNYDNKQV mutant (UNP residues 2962-2969) ;
Mutation：W2962Q, H2963N, T2964Y, M2965D, K2966N, N2967K, Y2928Q, Y2969V GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；294 K；20% w/v PEG3350, 0.1 M ammonium sulfate, 0.1 M HEPES
Resolution 2.35 Å R-free 0.225
7MNZ Crystal Structure of Nup358/RanBP2 Ran-binding domain 4 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 2911–3045（135 aa） Fragment：;RAN-binding domain 4 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2911-3045), WHTMKNYY/QNYDNKQV mutant (UNP residues 2962-2969) ;
Mutation：W2962Q, H2963N, T2964Y, M2965D, K2966N, N2967K, Y2928Q, Y2969V GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；294 K；20% w/v PEG3350, 0.1 M ammonium sulfate, 0.1 M HEPES
Resolution 2.35 Å R-free 0.225
7MNZ Crystal Structure of Nup358/RanBP2 Ran-binding domain 4 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 2911–3045（135 aa） Fragment：;RAN-binding domain 4 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2911-3045), WHTMKNYY/QNYDNKQV mutant (UNP residues 2962-2969) ;
Mutation：W2962Q, H2963N, T2964Y, M2965D, K2966N, N2967K, Y2928Q, Y2969V GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；294 K；20% w/v PEG3350, 0.1 M ammonium sulfate, 0.1 M HEPES
Resolution 2.35 Å R-free 0.225
7MNZ Crystal Structure of Nup358/RanBP2 Ran-binding domain 4 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain J 2911–3045（135 aa） Fragment：;RAN-binding domain 4 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2911-3045), WHTMKNYY/QNYDNKQV mutant (UNP residues 2962-2969) ;
Mutation：W2962Q, H2963N, T2964Y, M2965D, K2966N, N2967K, Y2928Q, Y2969V GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；294 K；20% w/v PEG3350, 0.1 M ammonium sulfate, 0.1 M HEPES
Resolution 2.35 Å R-free 0.225
7MNZ Crystal Structure of Nup358/RanBP2 Ran-binding domain 4 in complex with Ran-GPPNHP Deposited 2021-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain L 2911–3045（135 aa） Fragment：;RAN-binding domain 4 of the E3 SUMO-PROTEIN LIGASE RANBP2 (UNP residues 2911-3045), WHTMKNYY/QNYDNKQV mutant (UNP residues 2962-2969) ;
Mutation：W2962Q, H2963N, T2964Y, M2965D, K2966N, N2967K, Y2928Q, Y2969V GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；294 K；20% w/v PEG3350, 0.1 M ammonium sulfate, 0.1 M HEPES
Resolution 2.35 Å R-free 0.225
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain 00 1–3224（3224 aa）
Chain 01 1–3224（3224 aa）
Chain 02 1–3224（3224 aa）
Chain 03 1–3224（3224 aa）
Chain 04 1–3224（3224 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å
9B62 Human RANBP2/RAN(GTP)/RANGAP1-SUMO1/UBC9/CRM1/RAN(GTP) - composite map and model Deposited 2024-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain E 2446–3060（615 aa）
Not recorded GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；20 mM Tris-Cl pH 8.0, 50 mM NaCl, 0.1 mM TCEP supplemented with 0.02% (v/v) IGEPAL CA-630
cryo-EM vitrification conditions Cryogen ETHANE；30 s wait time, blot for 2.5 s before plunging
Resolution 2.90 Å

31 other PDB entries and 68 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name RBP2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain 00； PDBConstruct 1–3224； UniProt 1–3224 Author chain 01； PDBConstruct 1–3224； UniProt 1–3224 Author chain 02； PDBConstruct 1–3224； UniProt 1–3224 Author chain 03； PDBConstruct 1–3224； UniProt 1–3224 Author chain 04； PDBConstruct 1–3224； UniProt 1–3224

Nuclear pore membrane glycoprotein 210

OrganismNot specified

UniProt Q8TEM1

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain 10； UniProt 1–1887 Chain 11； UniProt 1–1887 Chain 12； UniProt 1–1887 Chain 13； UniProt 1–1887 Chain 14； UniProt 1–1887 Chain 15； UniProt 1–1887 Chain 16； UniProt 1–1887 Chain 17； UniProt 1–1887 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain 10 1–1887（1887 aa）
Chain 11 1–1887（1887 aa）
Chain 12 1–1887（1887 aa）
Chain 13 1–1887（1887 aa）
Chain 14 1–1887（1887 aa）
Chain 15 1–1887（1887 aa）
Chain 16 1–1887（1887 aa）
Chain 17 1–1887（1887 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

1 other PDB entries and 1 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name PO210_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain 10； PDBConstruct 1–1887； UniProt 1–1887 Author chain 11； PDBConstruct 1–1887； UniProt 1–1887 Author chain 12； PDBConstruct 1–1887； UniProt 1–1887 Author chain 13； PDBConstruct 1–1887； UniProt 1–1887 Author chain 14； PDBConstruct 1–1887； UniProt 1–1887 Author chain 15； PDBConstruct 1–1887； UniProt 1–1887 Author chain 16； PDBConstruct 1–1887； UniProt 1–1887 Author chain 17； PDBConstruct 1–1887； UniProt 1–1887

Aladin

OrganismNot specified

UniProt Q9NRG9

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain 40； UniProt 1–546 Chain 41； UniProt 1–546 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain 40 1–546（546 aa）
Chain 41 1–546（546 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

1 other PDB entries and 1 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name AAAS_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain 40； PDBConstruct 1–546； UniProt 1–546 Author chain 41； PDBConstruct 1–546； UniProt 1–546

Nuclear pore complex protein Nup93

OrganismNot specified

UniProt Q8N1F7

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain A0； UniProt 1–819 Chain A1； UniProt 1–819 Chain A2； UniProt 1–819 Chain A3； UniProt 1–819 Chain A4； UniProt 1–819 Chain A5； UniProt 1–819 Chain A6； UniProt 1–819 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5IJN Composite structure of the inner ring of the human nuclear pore complex (32 copies of Nup205) Deposited 2016-03-02 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 208 PDB declaration: 208-meric
Chain C 1–819（819 aa）
Chain I 1–819（819 aa）
Chain O 1–819（819 aa）
Chain U 1–819（819 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 21.40 Å
5IJO Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205) Deposited 2016-03-02 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 208 PDB declaration: 208-meric
Chain C 1–819（819 aa）
Chain I 1–819（819 aa）
Chain O 1–819（819 aa）
Chain U 1–819（819 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 21.40 Å
7MW0 Crystal structure of Homo sapiens NUP93 solenoid (residues 174-819) Deposited 2021-05-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 174–819（646 aa）
Not recorded EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；294 K；0.075 M TRIS pH 8.5, 19 % (w/v) PEG 20000
Resolution 2.00 Å R-free 0.254
7MW1 Crystal structure of the Homo sapiens NUP93-NUP53 complex (NUP93 residues 174-819; NUP53 residues 84-150) Deposited 2021-05-15 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 174–819（646 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；294 K；0.075 M TRIS pH 8.5, 17% (w/v) PEG 20000
Resolution 3.40 Å R-free 0.276
7MW1 Crystal structure of the Homo sapiens NUP93-NUP53 complex (NUP93 residues 174-819; NUP53 residues 84-150) Deposited 2021-05-15 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 174–819（646 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；294 K；0.075 M TRIS pH 8.5, 17% (w/v) PEG 20000
Resolution 3.40 Å R-free 0.276
7PER Model of the inner ring of the human nuclear pore complex Deposited 2021-08-11 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 192 PDB declaration: 192-meric
Chain C 1–819（819 aa）
Chain I 1–819（819 aa）
Chain O 1–819（819 aa）
Chain U 1–819（819 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；Cells were grown on holey carbon, Au-mesh supports. Grids were rinsed briefly with PBS and manually blotted before plunging into liquid ethane.
Resolution 35.00 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain A0 1–819（819 aa）
Chain A1 1–819（819 aa）
Chain A2 1–819（819 aa）
Chain A3 1–819（819 aa）
Chain A4 1–819（819 aa）
Chain A5 1–819（819 aa）
Chain A6 1–819（819 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

6 other PDB entries and 7 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NUP93_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain A0； PDBConstruct 1–819； UniProt 1–819 Author chain A1； PDBConstruct 1–819； UniProt 1–819 Author chain A2； PDBConstruct 1–819； UniProt 1–819 Author chain A3； PDBConstruct 1–819； UniProt 1–819 Author chain A4； PDBConstruct 1–819； UniProt 1–819 Author chain A5； PDBConstruct 1–819； UniProt 1–819 Author chain A6； PDBConstruct 1–819； UniProt 1–819

Nucleoporin NUP188 homolog

OrganismNot specified

UniProt Q5SRE5

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain B0； UniProt 1–1749 Chain B1； UniProt 1–1749 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5IJO Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205) Deposited 2016-03-02 Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 208 PDB declaration: 208-meric
Chain J 1–1749（1749 aa）
Chain V 1–1749（1749 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 21.40 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain B0 1–1749（1749 aa）
Chain B1 1–1749（1749 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

2 other PDB entries and 2 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NU188_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain B0； PDBConstruct 1–1749； UniProt 1–1749 Author chain B1； PDBConstruct 1–1749； UniProt 1–1749

Nuclear pore complex protein Nup205

OrganismNot specified

UniProt Q92621

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain C0； UniProt 1–2012 Chain C1； UniProt 1–2012 Chain C2； UniProt 1–2012 Chain C3； UniProt 1–2012 Chain C4； UniProt 1–2012 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5IJN Composite structure of the inner ring of the human nuclear pore complex (32 copies of Nup205) Deposited 2016-03-02 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 208 PDB declaration: 208-meric
Chain D 1–2012（2012 aa）
Chain J 1–2012（2012 aa）
Chain P 1–2012（2012 aa）
Chain V 1–2012（2012 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 21.40 Å
5IJO Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205) Deposited 2016-03-02 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 208 PDB declaration: 208-meric
Chain D 1–2012（2012 aa）
Chain P 1–2012（2012 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 21.40 Å
7PER Model of the inner ring of the human nuclear pore complex Deposited 2021-08-11 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 192 PDB declaration: 192-meric
Chain D 1–2012（2012 aa）
Chain J 1–2012（2012 aa）
Chain P 1–2012（2012 aa）
Chain V 1–2012（2012 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；Cells were grown on holey carbon, Au-mesh supports. Grids were rinsed briefly with PBS and manually blotted before plunging into liquid ethane.
Resolution 35.00 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain C0 1–2012（2012 aa）
Chain C1 1–2012（2012 aa）
Chain C2 1–2012（2012 aa）
Chain C3 1–2012（2012 aa）
Chain C4 1–2012（2012 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NU205_HUMAN
Isoform —
PDB entities 6
Chains and sequence ranges Author chain C0； PDBConstruct 1–2012； UniProt 1–2012 Author chain C1； PDBConstruct 1–2012； UniProt 1–2012 Author chain C2； PDBConstruct 1–2012； UniProt 1–2012 Author chain C3； PDBConstruct 1–2012； UniProt 1–2012 Author chain C4； PDBConstruct 1–2012； UniProt 1–2012

Nuclear pore complex protein Nup155

OrganismNot specified

UniProt O75694

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain D0； UniProt 1–1391 Chain D1； UniProt 1–1391 Chain D2； UniProt 1–1391 Chain D3； UniProt 1–1391 Chain D4； UniProt 1–1391 Chain D5； UniProt 1–1391 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5A9Q Human nuclear pore complex Deposited 2015-07-22 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 304 PDB declaration: 304-meric
Chain A 1–1391（1391 aa）
Chain B 1–1391（1391 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20MM TRIS, 0.2-0.4% TREHALOSE；pH 7.5；20MM TRIS, 0.2-0.4% TREHALOSE
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE；VITRIFICATION 1 -- CRYOGEN- ETHANE-PROPANE MIXTURE, INSTRUMENT- HOMEMADE PLUNGER,
Resolution 23.00 Å
5IJN Composite structure of the inner ring of the human nuclear pore complex (32 copies of Nup205) Deposited 2016-03-02 Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 208 PDB declaration: 208-meric
Chain A 1–1391（1391 aa）
Chain B 1–1391（1391 aa）
Chain E 1–1391（1391 aa）
Chain K 1–1391（1391 aa）
Chain Q 1–1391（1391 aa）
Chain W 1–1391（1391 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 21.40 Å
5IJO Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205) Deposited 2016-03-02 Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 208 PDB declaration: 208-meric
Chain A 1–1391（1391 aa）
Chain B 1–1391（1391 aa）
Chain E 1–1391（1391 aa）
Chain K 1–1391（1391 aa）
Chain Q 1–1391（1391 aa）
Chain W 1–1391（1391 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 21.40 Å
7EYE Cryo-EM (SPA) structure of Nup155 N-terminus (19-863) at 5.1 Angstrom resolution Deposited 2021-05-30 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–863（863 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；Buffer was freshly made.
cryo-EM vitrification conditions Cryogen ETHANE；Blot for 3 seconds before plunging
Resolution 5.10 Å
7EYF Cryo-EM (SPA) structure of human Nup155 C-terminus (864-1337) at 5.3 Angstroms resolution Deposited 2021-05-30 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 864–1391（528 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；Buffer was freshly made.
cryo-EM vitrification conditions Cryogen ETHANE；Blot for 3 seconds before plunging
Resolution 5.30 Å
7EYQ Cryo-EM (SPA) structure of human Nup155 Longer N-terminus (19-1069) at 5.4 Angstrom resolution Deposited 2021-05-31 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–1391（1391 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；Buffer was freshly made.
cryo-EM vitrification conditions Cryogen ETHANE；Blot for 3 seconds before plunging
Resolution 5.40 Å
7PER Model of the inner ring of the human nuclear pore complex Deposited 2021-08-11 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 192 PDB declaration: 192-meric
Chain E 1–1391（1391 aa）
Chain K 1–1391（1391 aa）
Chain Q 1–1391（1391 aa）
Chain W 1–1391（1391 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；Cells were grown on holey carbon, Au-mesh supports. Grids were rinsed briefly with PBS and manually blotted before plunging into liquid ethane.
Resolution 35.00 Å
7R1Y cryoEM structure of human Nup155 (residues 19-981) Deposited 2022-02-03 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–1391（1390 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain D0 1–1391（1391 aa）
Chain D1 1–1391（1391 aa）
Chain D2 1–1391（1391 aa）
Chain D3 1–1391（1391 aa）
Chain D4 1–1391（1391 aa）
Chain D5 1–1391（1391 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

9 other PDB entries and 9 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NU155_HUMAN
Isoform —
PDB entities 7
Chains and sequence ranges Author chain D0； PDBConstruct 1–1391； UniProt 1–1391 Author chain D1； PDBConstruct 1–1391； UniProt 1–1391 Author chain D2； PDBConstruct 1–1391； UniProt 1–1391 Author chain D3； PDBConstruct 1–1391； UniProt 1–1391 Author chain D4； PDBConstruct 1–1391； UniProt 1–1391 Author chain D5； PDBConstruct 1–1391； UniProt 1–1391

Nucleoporin NDC1

OrganismNot specified

UniProt Q9BTX1

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain E0； UniProt 1–674 Chain E1； UniProt 1–674 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain E0 1–674（674 aa）
Chain E1 1–674（674 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

1 other PDB entries and 1 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NDC1_HUMAN
Isoform —
PDB entities 8
Chains and sequence ranges Author chain E0； PDBConstruct 1–674； UniProt 1–674 Author chain E1； PDBConstruct 1–674； UniProt 1–674

Nucleoporin NUP35

OrganismNot specified

UniProt Q8NFH5

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain F0； UniProt 1–326 Chain F1； UniProt 1–326 Chain F2； UniProt 1–326 Chain F3； UniProt 1–326 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
4LIR Crystal structure of a nucleoporin 35kDa (NUP35) from Homo sapiens at 2.46 A resolution Deposited 2013-07-03 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 151–266（116 aa） Fragment：UNP residues 151-266
Chain B 151–266（116 aa） Fragment：UNP residues 151-266
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4；277 K；20.0% MPD, 0.1M Citrate pH 4.0, NANODROP, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.46 Å R-free 0.206
7MW1 Crystal structure of the Homo sapiens NUP93-NUP53 complex (NUP93 residues 174-819; NUP53 residues 84-150) Deposited 2021-05-15 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 84–150（67 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；294 K；0.075 M TRIS pH 8.5, 17% (w/v) PEG 20000
Resolution 3.40 Å R-free 0.276
7MW1 Crystal structure of the Homo sapiens NUP93-NUP53 complex (NUP93 residues 174-819; NUP53 residues 84-150) Deposited 2021-05-15 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 84–150（67 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；294 K；0.075 M TRIS pH 8.5, 17% (w/v) PEG 20000
Resolution 3.40 Å R-free 0.276
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain F0 1–326（326 aa）
Chain F1 1–326（326 aa）
Chain F2 1–326（326 aa）
Chain F3 1–326（326 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å
8OZB Crystal structure of Nup35-Nb complex Deposited 2023-05-08 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 173–248（76 aa）
Chain F 173–248（76 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.05 M HEPES (pH 6.5); 25% v/v PEG400; 0.05 M NaCl, 0.01 M MgCl2.
Resolution 2.09 Å R-free 0.267

4 other PDB entries and 5 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NUP35_HUMAN
Isoform —
PDB entities 9
Chains and sequence ranges Author chain F0； PDBConstruct 1–326； UniProt 1–326 Author chain F1； PDBConstruct 1–326； UniProt 1–326 Author chain F2； PDBConstruct 1–326； UniProt 1–326 Author chain F3； PDBConstruct 1–326； UniProt 1–326

Nucleoporin p54

OrganismNot specified

UniProt Q7Z3B4

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain H0； UniProt 1–507 Chain H1； UniProt 1–507 Chain H2； UniProt 1–507 Chain H3； UniProt 1–507 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
4JNU Crystal structure of the human Nup57CCS3* coiled-coil segment, space group P21 Deposited 2013-03-15 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 453–491（39 aa） Fragment：UNP residues 453-491
Chain B 453–491（39 aa） Fragment：UNP residues 453-491
Chain C 453–491（39 aa） Fragment：UNP residues 453-491
Chain D 453–491（39 aa） Fragment：UNP residues 453-491
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.3；294 K；0.1 M sodium acetate, pH 5.3, 1.9 M sodium formate, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 1.45 Å R-free 0.218
4JNV Crystal structure of the human Nup57CCS3* coiled-coil segment, space group C2 Deposited 2013-03-15 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 453–491（39 aa） Fragment：UNP residues 453-491
Chain B 453–491（39 aa） Fragment：UNP residues 453-491
Chain C 453–491（39 aa） Fragment：UNP residues 453-491
Chain D 453–491（39 aa） Fragment：UNP residues 453-491
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.3；294 K；0.1 M sodium acetate, pH 5.3, 1.9 M sodium formate, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 1.85 Å R-free 0.277
4JO7 Crystal structure of the human Nup49CCS2+3* Nup57CCS3* complex with 2:2 stoichiometry Deposited 2013-03-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 453–491（39 aa） Fragment：UNP residues 453-491
Chain D 453–491（39 aa） Fragment：UNP residues 453-491
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；294 K；0.1 M MES, pH 6.5, 6.7% PEG20000, VAPOR DIFFUSION, HANGING DROP, temperature 294.0K
Resolution 1.75 Å R-free 0.214
4JO7 Crystal structure of the human Nup49CCS2+3* Nup57CCS3* complex with 2:2 stoichiometry Deposited 2013-03-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 453–491（39 aa） Fragment：UNP residues 453-491
Chain H 453–491（39 aa） Fragment：UNP residues 453-491
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；294 K；0.1 M MES, pH 6.5, 6.7% PEG20000, VAPOR DIFFUSION, HANGING DROP, temperature 294.0K
Resolution 1.75 Å R-free 0.214
4JO9 Crystal structure of the human Nup49CCS2+3* Nup57CCS3* complex 1:2 stoichiometry Deposited 2013-03-18 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 453–491（39 aa） Fragment：UNP residues 453-491
Chain C 453–491（39 aa） Fragment：UNP residues 453-491
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 3.8；294 K；0.1 M sodium citrate, pH 3.8, 0.07 M calcium chloride, VAPOR DIFFUSION, temperature 294.0K
Resolution 2.50 Å R-free 0.294
5IJN Composite structure of the inner ring of the human nuclear pore complex (32 copies of Nup205) Deposited 2016-03-02 Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 208 PDB declaration: 208-meric
Chain F 1–507（507 aa）
Chain L 1–507（507 aa）
Chain R 1–507（507 aa）
Chain X 1–507（507 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 21.40 Å
5IJO Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205) Deposited 2016-03-02 Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 208 PDB declaration: 208-meric
Chain F 1–507（507 aa）
Chain L 1–507（507 aa）
Chain R 1–507（507 aa）
Chain X 1–507（507 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 21.40 Å
7PER Model of the inner ring of the human nuclear pore complex Deposited 2021-08-11 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 192 PDB declaration: 192-meric
Chain F 1–507（507 aa）
Chain L 1–507（507 aa）
Chain R 1–507（507 aa）
Chain X 1–507（507 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；Cells were grown on holey carbon, Au-mesh supports. Grids were rinsed briefly with PBS and manually blotted before plunging into liquid ethane.
Resolution 35.00 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain H0 1–507（507 aa）
Chain H1 1–507（507 aa）
Chain H2 1–507（507 aa）
Chain H3 1–507（507 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

8 other PDB entries and 9 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NUP54_HUMAN
Isoform —
PDB entities 10
Chains and sequence ranges Author chain H0； PDBConstruct 1–507； UniProt 1–507 Author chain H1； PDBConstruct 1–507； UniProt 1–507 Author chain H2； PDBConstruct 1–507； UniProt 1–507 Author chain H3； PDBConstruct 1–507； UniProt 1–507

Nucleoporin p58/p45

OrganismNot specified

UniProt Q9BVL2

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain I0； UniProt 1–599 Chain I1； UniProt 1–599 Chain I2； UniProt 1–599 Chain I3； UniProt 1–599 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
4JO7 Crystal structure of the human Nup49CCS2+3* Nup57CCS3* complex with 2:2 stoichiometry Deposited 2013-03-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 341–428（88 aa） Fragment：UNP residues 341-428
Chain C 341–428（88 aa） Fragment：UNP residues 341-428
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；294 K；0.1 M MES, pH 6.5, 6.7% PEG20000, VAPOR DIFFUSION, HANGING DROP, temperature 294.0K
Resolution 1.75 Å R-free 0.214
4JO7 Crystal structure of the human Nup49CCS2+3* Nup57CCS3* complex with 2:2 stoichiometry Deposited 2013-03-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 341–428（88 aa） Fragment：UNP residues 341-428
Chain G 341–428（88 aa） Fragment：UNP residues 341-428
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；294 K；0.1 M MES, pH 6.5, 6.7% PEG20000, VAPOR DIFFUSION, HANGING DROP, temperature 294.0K
Resolution 1.75 Å R-free 0.214
4JO9 Crystal structure of the human Nup49CCS2+3* Nup57CCS3* complex 1:2 stoichiometry Deposited 2013-03-18 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 341–426（86 aa） Fragment：UNP residues 341-426
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 3.8；294 K；0.1 M sodium citrate, pH 3.8, 0.07 M calcium chloride, VAPOR DIFFUSION, temperature 294.0K
Resolution 2.50 Å R-free 0.294
4JQ5 Crystal structure of the human Nup49CCS2+3* coiled-coil segment Deposited 2013-03-20 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 341–425（85 aa） Fragment：UNP residues 341-425
Chain B 341–425（85 aa） Fragment：UNP residues 341-425
Chain C 341–425（85 aa） Fragment：UNP residues 341-425
Chain D 341–425（85 aa） Fragment：UNP residues 341-425
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；294 K；10% glycerol, 28% dioxane, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 294.0K
Resolution 2.19 Å R-free 0.293
4JQ5 Crystal structure of the human Nup49CCS2+3* coiled-coil segment Deposited 2013-03-20 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain E 341–425（85 aa） Fragment：UNP residues 341-425
Chain F 341–425（85 aa） Fragment：UNP residues 341-425
Chain G 341–425（85 aa） Fragment：UNP residues 341-425
Chain H 341–425（85 aa） Fragment：UNP residues 341-425
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；294 K；10% glycerol, 28% dioxane, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 294.0K
Resolution 2.19 Å R-free 0.293
4JQ5 Crystal structure of the human Nup49CCS2+3* coiled-coil segment Deposited 2013-03-20 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain I 341–425（85 aa） Fragment：UNP residues 341-425
Chain J 341–425（85 aa） Fragment：UNP residues 341-425
Chain K 341–425（85 aa） Fragment：UNP residues 341-425
Chain L 341–425（85 aa） Fragment：UNP residues 341-425
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；294 K；10% glycerol, 28% dioxane, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 294.0K
Resolution 2.19 Å R-free 0.293
5IJN Composite structure of the inner ring of the human nuclear pore complex (32 copies of Nup205) Deposited 2016-03-02 Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 208 PDB declaration: 208-meric
Chain G 1–599（599 aa）
Chain M 1–599（599 aa）
Chain S 1–599（599 aa）
Chain Y 1–599（599 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 21.40 Å
5IJO Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205) Deposited 2016-03-02 Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 208 PDB declaration: 208-meric
Chain G 1–599（599 aa）
Chain M 1–599（599 aa）
Chain S 1–599（599 aa）
Chain Y 1–599（599 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 21.40 Å
7PER Model of the inner ring of the human nuclear pore complex Deposited 2021-08-11 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 192 PDB declaration: 192-meric
Chain G 1–599（599 aa）
Chain M 1–599（599 aa）
Chain S 1–599（599 aa）
Chain Y 1–599（599 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；Cells were grown on holey carbon, Au-mesh supports. Grids were rinsed briefly with PBS and manually blotted before plunging into liquid ethane.
Resolution 35.00 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain I0 1–599（599 aa）
Chain I1 1–599（599 aa）
Chain I2 1–599（599 aa）
Chain I3 1–599（599 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

7 other PDB entries and 10 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NUP58_HUMAN
Isoform —
PDB entities 11
Chains and sequence ranges Author chain I0； PDBConstruct 1–599； UniProt 1–599 Author chain I1； PDBConstruct 1–599； UniProt 1–599 Author chain I2； PDBConstruct 1–599； UniProt 1–599 Author chain I3； PDBConstruct 1–599； UniProt 1–599

Nuclear pore glycoprotein p62

OrganismNot specified

UniProt P37198

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain J0； UniProt 1–522 Chain J1； UniProt 1–522 Chain J2； UniProt 1–522 Chain J3； UniProt 1–522 Chain J4； UniProt 1–522 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5IJN Composite structure of the inner ring of the human nuclear pore complex (32 copies of Nup205) Deposited 2016-03-02 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 208 PDB declaration: 208-meric
Chain H 1–522（522 aa）
Chain N 1–522（522 aa）
Chain T 1–522（522 aa）
Chain Z 1–522（522 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 21.40 Å
5IJO Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205) Deposited 2016-03-02 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 208 PDB declaration: 208-meric
Chain H 1–522（522 aa）
Chain N 1–522（522 aa）
Chain T 1–522（522 aa）
Chain Z 1–522（522 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 21.40 Å
7PER Model of the inner ring of the human nuclear pore complex Deposited 2021-08-11 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 192 PDB declaration: 192-meric
Chain H 1–522（522 aa）
Chain N 1–522（522 aa）
Chain T 1–522（522 aa）
Chain Z 1–522（522 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；Cells were grown on holey carbon, Au-mesh supports. Grids were rinsed briefly with PBS and manually blotted before plunging into liquid ethane.
Resolution 35.00 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain J0 1–522（522 aa）
Chain J1 1–522（522 aa）
Chain J2 1–522（522 aa）
Chain J3 1–522（522 aa）
Chain J4 1–522（522 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NUP62_HUMAN
Isoform —
PDB entities 12
Chains and sequence ranges Author chain J0； PDBConstruct 1–522； UniProt 1–522 Author chain J1； PDBConstruct 1–522； UniProt 1–522 Author chain J2； PDBConstruct 1–522； UniProt 1–522 Author chain J3； PDBConstruct 1–522； UniProt 1–522 Author chain J4； PDBConstruct 1–522； UniProt 1–522

Nuclear pore complex protein Nup133

OrganismNot specified

UniProt Q8WUM0

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain K0； UniProt 1–1156 Chain K1； UniProt 1–1156 Chain K2； UniProt 1–1156 Chain K3； UniProt 1–1156 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1XKS The crystal structure of the N-terminal domain of Nup133 reveals a beta-propeller fold common to several nucleoporins Deposited 2004-09-29 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 67–514（448 aa）
Mutation：F345L No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.7；277 K；PEG 3350, lithium sulfate, bis-tris, pH 5.7, VAPOR DIFFUSION, HANGING DROP, temperature 277.0K, pH 5.70
Resolution 2.35 Å R-free 0.236
3CQC Nucleoporin Nup107/Nup133 interaction complex Deposited 2008-04-02 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 935–1156（222 aa） Fragment：residues 935-1156
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；289 K；0.1M Hepes, 1.1M sodium malonate, 1-1.5% PEG MME 5000, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 2.53 Å R-free 0.245
3CQG Nucleoporin Nup107/Nup133 interaction complex, delta finger mutant Deposited 2008-04-02 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 934–1156（223 aa） Fragment：residues 935-1156
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；289 K；25-27% PEG 2000 MME, 500mM KSCN, 0.1M Hepes, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 3.00 Å R-free 0.287
3I4R Nup107(aa658-925)/Nup133(aa517-1156) complex, H.sapiens Deposited 2009-07-02 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 517–1156（640 aa） Fragment：HELICAL DOMAIN (UNP residues 517-1156)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.8；291 K；0.8 M sodium/potassium phosphate, 15 % glycerol, 2% PEG 3350, pH 7.8, VAPOR DIFFUSION, HANGING DROP, temperature 291K
Resolution 3.53 Å R-free 0.370
5A9Q Human nuclear pore complex Deposited 2015-07-22 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 304 PDB declaration: 304-meric
Chain 3 1–1156（1156 aa）
Chain C 1–1156（1156 aa）
Chain L 1–1156（1156 aa）
Chain U 1–1156（1156 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20MM TRIS, 0.2-0.4% TREHALOSE；pH 7.5；20MM TRIS, 0.2-0.4% TREHALOSE
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE；VITRIFICATION 1 -- CRYOGEN- ETHANE-PROPANE MIXTURE, INSTRUMENT- HOMEMADE PLUNGER,
Resolution 23.00 Å
7PEQ Model of the outer rings of the human nuclear pore complex Deposited 2021-08-11 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 288 PDB declaration: 288-meric
Chain AC 1–1156（1156 aa）
Chain BC 1–1156（1156 aa）
Chain CC 1–1156（1156 aa）
Chain DC 1–1156（1156 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；Cells were grown on holey carbon, Au-mesh supports. Grids were rinsed briefly with PBS and manually blotted before plunging into liquid ethane.
Resolution 35.00 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain K0 1–1156（1156 aa）
Chain K1 1–1156（1156 aa）
Chain K2 1–1156（1156 aa）
Chain K3 1–1156（1156 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

7 other PDB entries and 7 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NU133_HUMAN
Isoform —
PDB entities 13
Chains and sequence ranges Author chain K0； PDBConstruct 1–1156； UniProt 1–1156 Author chain K1； PDBConstruct 1–1156； UniProt 1–1156 Author chain K2； PDBConstruct 1–1156； UniProt 1–1156 Author chain K3； PDBConstruct 1–1156； UniProt 1–1156

Nuclear pore complex protein Nup107

OrganismNot specified

UniProt P57740

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain L0； UniProt 1–925 Chain L1； UniProt 1–925 Chain L2； UniProt 1–925 Chain L3； UniProt 1–925 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
3CQC Nucleoporin Nup107/Nup133 interaction complex Deposited 2008-04-02 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 658–925（268 aa） Fragment：residues 658-925
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；289 K；0.1M Hepes, 1.1M sodium malonate, 1-1.5% PEG MME 5000, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 2.53 Å R-free 0.245
3CQG Nucleoporin Nup107/Nup133 interaction complex, delta finger mutant Deposited 2008-04-02 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 658–771（114 aa） Fragment：residues 658-771, 802-925, connected by linker GGSGGS
Chain A 802–925（124 aa） Fragment：residues 658-771, 802-925, connected by linker GGSGGS
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；289 K；25-27% PEG 2000 MME, 500mM KSCN, 0.1M Hepes, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 3.00 Å R-free 0.287
3I4R Nup107(aa658-925)/Nup133(aa517-1156) complex, H.sapiens Deposited 2009-07-02 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 658–925（268 aa） Fragment：C-TERMINAL FRAGMENT (UNP residues 658-925)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.8；291 K；0.8 M sodium/potassium phosphate, 15 % glycerol, 2% PEG 3350, pH 7.8, VAPOR DIFFUSION, HANGING DROP, temperature 291K
Resolution 3.53 Å R-free 0.370
5A9Q Human nuclear pore complex Deposited 2015-07-22 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 304 PDB declaration: 304-meric
Chain 4 1–925（925 aa）
Chain D 1–925（925 aa）
Chain M 1–925（925 aa）
Chain V 1–925（925 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20MM TRIS, 0.2-0.4% TREHALOSE；pH 7.5；20MM TRIS, 0.2-0.4% TREHALOSE
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE；VITRIFICATION 1 -- CRYOGEN- ETHANE-PROPANE MIXTURE, INSTRUMENT- HOMEMADE PLUNGER,
Resolution 23.00 Å
7PEQ Model of the outer rings of the human nuclear pore complex Deposited 2021-08-11 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 288 PDB declaration: 288-meric
Chain AD 1–925（925 aa）
Chain BD 1–925（925 aa）
Chain CD 1–925（925 aa）
Chain DD 1–925（925 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；Cells were grown on holey carbon, Au-mesh supports. Grids were rinsed briefly with PBS and manually blotted before plunging into liquid ethane.
Resolution 35.00 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain L0 1–925（925 aa）
Chain L1 1–925（925 aa）
Chain L2 1–925（925 aa）
Chain L3 1–925（925 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NU107_HUMAN
Isoform —
PDB entities 14
Chains and sequence ranges Author chain L0； PDBConstruct 1–925； UniProt 1–925 Author chain L1； PDBConstruct 1–925； UniProt 1–925 Author chain L2； PDBConstruct 1–925； UniProt 1–925 Author chain L3； PDBConstruct 1–925； UniProt 1–925

Nuclear pore complex protein Nup96

OrganismNot specified

UniProt P52948

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain M0； UniProt 881–1817 Chain M1； UniProt 881–1817 Chain M2； UniProt 881–1817 Chain M3； UniProt 881–1817 Chain U0； UniProt 1–880 Chain U1； UniProt 1–880 Chain U2； UniProt 1–880 Chain U3； UniProt 1–880 Chain U4； UniProt 1–880 Chain U5； UniProt 1–880 Chain U6； UniProt 1–880 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1KO6 Crystal Structure of C-terminal Autoproteolytic Domain of Nucleoporin Nup98 Deposited 2001-12-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 678–863（186 aa） Fragment：C-terminal Autoproteolytic Domain (Sequence database residues 677-863)
Chain B 864–920（57 aa） Fragment：C-terminal Autoproteolytic Domain (Sequence database residues 864-920)
Chain C 678–863（186 aa） Fragment：C-terminal Autoproteolytic Domain (Sequence database residues 677-863)
Chain D 864–920（57 aa） Fragment：C-terminal Autoproteolytic Domain (Sequence database residues 864-920)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.75；300 K；MgCl, PEG8000, Tris, pH 8.75, VAPOR DIFFUSION, HANGING DROP, temperature 300K
Resolution 3.00 Å R-free 0.271
2Q5X Crystal Structure of the C-terminal domain of hNup98 Deposited 2007-06-03 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 733–887（155 aa） Fragment：C-terminal domain, residues 733-887
Mutation：S881A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.6；296 K；4.5M sodium formate, pH 4.6, vapor diffusion, hanging drop, temperature 296K
Resolution 1.90 Å R-free 0.229
2Q5Y Crystal Structure of the C-terminal domain of hNup98 Deposited 2007-06-03 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 729–880（152 aa） Fragment：C-terminal domain, residues 729-880
Chain B 881–887（7 aa） Fragment：residues 881-887
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.1；296 K；0.1M Tris, 0.2M MgAc2, 22% PEG8000, microseeding, pH 8.1, vapor diffusion, hanging drop, temperature 296K
Resolution 2.30 Å R-free 0.260
2Q5Y Crystal Structure of the C-terminal domain of hNup98 Deposited 2007-06-03 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 729–880（152 aa） Fragment：C-terminal domain, residues 729-880
Chain D 881–887（7 aa） Fragment：residues 881-887
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.1；296 K；0.1M Tris, 0.2M MgAc2, 22% PEG8000, microseeding, pH 8.1, vapor diffusion, hanging drop, temperature 296K
Resolution 2.30 Å R-free 0.260
3MMY Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1 Deposited 2010-04-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 158–213（56 aa） Fragment：UNP residues 158-213
Not recorded MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP
Resolution 1.65 Å R-free 0.237
3MMY Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1 Deposited 2010-04-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 158–213（56 aa） Fragment：UNP residues 158-213
Not recorded MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP
Resolution 1.65 Å R-free 0.237
3MMY Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1 Deposited 2010-04-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 158–213（56 aa） Fragment：UNP residues 158-213
Not recorded MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP
Resolution 1.65 Å R-free 0.237
3MMY Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1 Deposited 2010-04-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 158–213（56 aa） Fragment：UNP residues 158-213
Not recorded MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP
Resolution 1.65 Å R-free 0.237
4OWR Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair Rae1-Nup98 Deposited 2014-02-03 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 157–213（57 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；298 K；0.1 M HEPES pH 7.5, 11% PEG 10, 000, and 10% MPD
Resolution 3.15 Å R-free 0.289
5A9Q Human nuclear pore complex Deposited 2015-07-22 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 304 PDB declaration: 304-meric
Chain 5 881–1817（937 aa）
Chain E 881–1817（937 aa）
Chain N 881–1817（937 aa）
Chain W 881–1817（937 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20MM TRIS, 0.2-0.4% TREHALOSE；pH 7.5；20MM TRIS, 0.2-0.4% TREHALOSE
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE；VITRIFICATION 1 -- CRYOGEN- ETHANE-PROPANE MIXTURE, INSTRUMENT- HOMEMADE PLUNGER,
Resolution 23.00 Å
6BZM GFGNFGTS from low-complexity/FG repeat domain of Nup98, residues 116-123 Deposited 2017-12-24 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 116–123（8 aa） Fragment：UNP residues 116-123
Chain B 116–123（8 aa） Fragment：UNP residues 116-123
Not recorded No recorded non-water small molecule ELECTRON CRYSTALLOGRAPHY
cryo-EM buffer pH 9.5
cryo-EM vitrification conditions Cryogen ETHANE
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；298 K；0.1 M CHES, pH 9.5, 10% ethanol
Resolution 0.90 Å R-free 0.264
7F60 Crystal structure of auxiliary protein in complex with human nuclear protein Deposited 2021-06-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain D 1–1817（1817 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；296 K；0.1m Bis-tris ph5.5,45%PEG4000
Resolution 2.85 Å R-free 0.276
7F60 Crystal structure of auxiliary protein in complex with human nuclear protein Deposited 2021-06-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 1–1817（1817 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；296 K；0.1m Bis-tris ph5.5,45%PEG4000
Resolution 2.85 Å R-free 0.276
7F90 Crystal structure of SARS auxiliary protein in complex with human nuclear protein Deposited 2021-07-03 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–1817（1817 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；296 K；0.1m Bis-tris ph5.5,45%PEG4000
Resolution 2.39 Å R-free 0.258
7F90 Crystal structure of SARS auxiliary protein in complex with human nuclear protein Deposited 2021-07-03 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain D 1–1817（1817 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；296 K；0.1m Bis-tris ph5.5,45%PEG4000
Resolution 2.39 Å R-free 0.258
7PEQ Model of the outer rings of the human nuclear pore complex Deposited 2021-08-11 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 288 PDB declaration: 288-meric
Chain AE 881–1817（937 aa）
Chain BE 881–1817（937 aa）
Chain CE 881–1817（937 aa）
Chain DE 881–1817（937 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；Cells were grown on holey carbon, Au-mesh supports. Grids were rinsed briefly with PBS and manually blotted before plunging into liquid ethane.
Resolution 35.00 Å
7Q64 Cryo-em structure of the Nup98 fibril polymorph 1 Deposited 2021-11-05 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 30 PDB declaration: 30-meric
Chain A 85–124（40 aa）
Chain B 85–124（40 aa）
Chain C 85–124（40 aa）
Chain D 85–124（40 aa）
Chain E 85–124（40 aa）
Chain F 85–124（40 aa）
Chain G 85–124（40 aa）
Chain H 85–124（40 aa）
Chain I 85–124（40 aa）
Chain J 85–124（40 aa）
Chain K 85–124（40 aa）
Chain L 85–124（40 aa）
Chain M 85–124（40 aa）
Chain N 85–124（40 aa）
Chain O 85–124（40 aa）
Chain P 85–124（40 aa）
Chain Q 85–124（40 aa）
Chain R 85–124（40 aa）
Chain S 85–124（40 aa）
Chain T 85–124（40 aa）
Chain U 85–124（40 aa）
Chain V 85–124（40 aa）
Chain W 85–124（40 aa）
Chain X 85–124（40 aa）
Chain Y 85–124（40 aa）
Chain Z 85–124（40 aa）
Chain a 85–124（40 aa）
Chain b 85–124（40 aa）
Chain c 85–124（40 aa）
Chain d 85–124（40 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.76 Å
7Q65 Cryo-em structure of the Nup98 fibril polymorph 2 Deposited 2021-11-05 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 22 PDB declaration: 22-meric
Chain A 85–124（40 aa）
Chain B 85–124（40 aa）
Chain C 85–124（40 aa）
Chain D 85–124（40 aa）
Chain E 85–124（40 aa）
Chain F 85–124（40 aa）
Chain G 85–124（40 aa）
Chain H 85–124（40 aa）
Chain I 85–124（40 aa）
Chain J 85–124（40 aa）
Chain K 85–124（40 aa）
Chain L 85–124（40 aa）
Chain M 85–124（40 aa）
Chain N 85–124（40 aa）
Chain O 85–124（40 aa）
Chain P 85–124（40 aa）
Chain Q 85–124（40 aa）
Chain R 85–124（40 aa）
Chain S 85–124（40 aa）
Chain T 85–124（40 aa）
Chain U 85–124（40 aa）
Chain V 85–124（40 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.32 Å
7Q66 Cryo-em structure of the Nup98 fibril polymorph 3 Deposited 2021-11-05 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 22 PDB declaration: 22-meric
Chain A 85–124（40 aa）
Chain B 85–124（40 aa）
Chain C 85–124（40 aa）
Chain D 85–124（40 aa）
Chain E 85–124（40 aa）
Chain F 85–124（40 aa）
Chain G 85–124（40 aa）
Chain H 85–124（40 aa）
Chain I 85–124（40 aa）
Chain J 85–124（40 aa）
Chain K 85–124（40 aa）
Chain L 85–124（40 aa）
Chain M 85–124（40 aa）
Chain N 85–124（40 aa）
Chain O 85–124（40 aa）
Chain P 85–124（40 aa）
Chain Q 85–124（40 aa）
Chain R 85–124（40 aa）
Chain S 85–124（40 aa）
Chain T 85–124（40 aa）
Chain U 85–124（40 aa）
Chain V 85–124（40 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
7Q67 Cryo-em structure of the Nup98 fibril polymorph 4 Deposited 2021-11-05 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 11 PDB declaration: undecameric
Chain A 85–124（40 aa）
Chain B 85–124（40 aa）
Chain C 85–124（40 aa）
Chain D 85–124（40 aa）
Chain E 85–124（40 aa）
Chain F 85–124（40 aa）
Chain G 85–124（40 aa）
Chain H 85–124（40 aa）
Chain I 85–124（40 aa）
Chain J 85–124（40 aa）
Chain K 85–124（40 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.37 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain M0 881–1817（937 aa）
Chain M1 881–1817（937 aa）
Chain M2 881–1817（937 aa）
Chain M3 881–1817（937 aa）
Chain U0 1–880（880 aa）
Chain U1 1–880（880 aa）
Chain U2 1–880（880 aa）
Chain U3 1–880（880 aa）
Chain U4 1–880（880 aa）
Chain U5 1–880（880 aa）
Chain U6 1–880（880 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å
7VPG Crystal structure of the C-terminal tail of SARS-CoV-1 Orf6 complex with human nucleoporin pair Rae1-Nup98 Deposited 2021-10-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 158–213（56 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；100 mM Sodium citrate pH 5.5, 20% PEG 3350
Resolution 2.49 Å R-free 0.231
7VPG Crystal structure of the C-terminal tail of SARS-CoV-1 Orf6 complex with human nucleoporin pair Rae1-Nup98 Deposited 2021-10-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain D 158–213（56 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；100 mM Sodium citrate pH 5.5, 20% PEG 3350
Resolution 2.49 Å R-free 0.231
7VPG Crystal structure of the C-terminal tail of SARS-CoV-1 Orf6 complex with human nucleoporin pair Rae1-Nup98 Deposited 2021-10-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain F 158–213（56 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；100 mM Sodium citrate pH 5.5, 20% PEG 3350
Resolution 2.49 Å R-free 0.231
7VPG Crystal structure of the C-terminal tail of SARS-CoV-1 Orf6 complex with human nucleoporin pair Rae1-Nup98 Deposited 2021-10-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain H 158–213（56 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；100 mM Sodium citrate pH 5.5, 20% PEG 3350
Resolution 2.49 Å R-free 0.231
7VPH Crystal structure of the C-terminal tail of SARS-CoV-2 Orf6 complex with human nucleoporin pair Rae1-Nup98 Deposited 2021-10-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 158–213（56 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；100 mM Sodium citrate pH 5.5, 20% PEG 3350
Resolution 2.80 Å R-free 0.244
7VPH Crystal structure of the C-terminal tail of SARS-CoV-2 Orf6 complex with human nucleoporin pair Rae1-Nup98 Deposited 2021-10-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain D 158–213（56 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；100 mM Sodium citrate pH 5.5, 20% PEG 3350
Resolution 2.80 Å R-free 0.244
7VPH Crystal structure of the C-terminal tail of SARS-CoV-2 Orf6 complex with human nucleoporin pair Rae1-Nup98 Deposited 2021-10-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain F 158–213（56 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；100 mM Sodium citrate pH 5.5, 20% PEG 3350
Resolution 2.80 Å R-free 0.244
7VPH Crystal structure of the C-terminal tail of SARS-CoV-2 Orf6 complex with human nucleoporin pair Rae1-Nup98 Deposited 2021-10-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain H 158–213（56 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；100 mM Sodium citrate pH 5.5, 20% PEG 3350
Resolution 2.80 Å R-free 0.244
8CI8 Cryo-EM structure of the Nup98(298-327) fibril Deposited 2023-02-09 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 25 PDB declaration: 25-meric
Chain A 298–327（30 aa）
Chain B 298–327（30 aa）
Chain C 298–327（30 aa）
Chain D 298–327（30 aa）
Chain E 298–327（30 aa）
Chain F 298–327（30 aa）
Chain G 298–327（30 aa）
Chain H 298–327（30 aa）
Chain I 298–327（30 aa）
Chain J 298–327（30 aa）
Chain K 298–327（30 aa）
Chain L 298–327（30 aa）
Chain M 298–327（30 aa）
Chain N 298–327（30 aa）
Chain O 298–327（30 aa）
Chain P 298–327（30 aa）
Chain Q 298–327（30 aa）
Chain R 298–327（30 aa）
Chain S 298–327（30 aa）
Chain T 298–327（30 aa）
Chain U 298–327（30 aa）
Chain V 298–327（30 aa）
Chain W 298–327（30 aa）
Chain X 298–327（30 aa）
Chain Y 298–327（30 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6.5；In water.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.67 Å
9PLL TRIM21-NUP98 Molecular Glue Complex (MAN-056) Deposited 2025-07-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 712–863（152 aa）
Not recorded A1BLD (3P)-3-(4-chloro-2-ethoxyphenyl)-6-fluoro-2-[(piperazin-1-yl)methyl]quinazolin-4(3H)-one × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；289 K；100 mM NaCl, 100 mM HEPES, pH 7.5, 12 % polyethylene glycol 20,000
Resolution 1.60 Å R-free 0.214
9PLM TRIM21-NUP98 Molecular Glue Complex (MAN-021) Deposited 2025-07-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 712–863（152 aa）
Not recorded A1CI1 (3P)-3-{4-chloro-2-[2-(dimethylamino)ethoxy]phenyl}-6-fluoro-2-[(piperazin-1-yl)methyl]quinazolin-4(3H)-one × 1 GOL GLYCEROL × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；100 mM NaCl, 100 mM HEPES, pH 7.5, 12 % polyethylene glycol 20,000
Resolution 1.32 Å R-free 0.178

20 other PDB entries and 32 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NUP98_HUMAN
Isoform —
PDB entities 15, 23
Chains and sequence ranges Author chain M0； PDBConstruct 1–937； UniProt 881–1817 Author chain M1； PDBConstruct 1–937； UniProt 881–1817 Author chain M2； PDBConstruct 1–937； UniProt 881–1817 Author chain M3； PDBConstruct 1–937； UniProt 881–1817 Author chain U0； PDBConstruct 1–880； UniProt 1–880 Author chain U1； PDBConstruct 1–880； UniProt 1–880 Author chain U2； PDBConstruct 1–880； UniProt 1–880 Author chain U3； PDBConstruct 1–880； UniProt 1–880 Author chain U4； PDBConstruct 1–880； UniProt 1–880 Author chain U5； PDBConstruct 1–880； UniProt 1–880 Author chain U6； PDBConstruct 1–880； UniProt 1–880

Protein SEC13 homolog

OrganismNot specified

UniProt P55735

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain N0； UniProt 1–322 Chain N1； UniProt 1–322 Chain N2； UniProt 1–322 Chain N3； UniProt 1–322 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
3BG0 Architecture of a Coat for the Nuclear Pore Membrane Deposited 2007-11-23 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–316（316 aa）
Chain D 1–316（316 aa）
Chain E 1–316（316 aa）
Chain H 1–316（316 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.7；294 K；16 % (w/v) PEG 3,350, 400 mM NaCl, 100 mM Na-K tartrate, and 100 mM BIS-TRIS, pH 7.7, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 3.15 Å R-free 0.294
3BG0 Architecture of a Coat for the Nuclear Pore Membrane Deposited 2007-11-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–316（316 aa）
Chain D 1–316（316 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.7；294 K；16 % (w/v) PEG 3,350, 400 mM NaCl, 100 mM Na-K tartrate, and 100 mM BIS-TRIS, pH 7.7, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 3.15 Å R-free 0.294
3BG0 Architecture of a Coat for the Nuclear Pore Membrane Deposited 2007-11-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 1–316（316 aa）
Chain H 1–316（316 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.7；294 K；16 % (w/v) PEG 3,350, 400 mM NaCl, 100 mM Na-K tartrate, and 100 mM BIS-TRIS, pH 7.7, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 3.15 Å R-free 0.294
3BG0 Architecture of a Coat for the Nuclear Pore Membrane Deposited 2007-11-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–316（316 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.7；294 K；16 % (w/v) PEG 3,350, 400 mM NaCl, 100 mM Na-K tartrate, and 100 mM BIS-TRIS, pH 7.7, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 3.15 Å R-free 0.294
3BG0 Architecture of a Coat for the Nuclear Pore Membrane Deposited 2007-11-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–316（316 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.7；294 K；16 % (w/v) PEG 3,350, 400 mM NaCl, 100 mM Na-K tartrate, and 100 mM BIS-TRIS, pH 7.7, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 3.15 Å R-free 0.294
3BG0 Architecture of a Coat for the Nuclear Pore Membrane Deposited 2007-11-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 1–316（316 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.7；294 K；16 % (w/v) PEG 3,350, 400 mM NaCl, 100 mM Na-K tartrate, and 100 mM BIS-TRIS, pH 7.7, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 3.15 Å R-free 0.294
3BG0 Architecture of a Coat for the Nuclear Pore Membrane Deposited 2007-11-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 7 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–316（316 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.7；294 K；16 % (w/v) PEG 3,350, 400 mM NaCl, 100 mM Na-K tartrate, and 100 mM BIS-TRIS, pH 7.7, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 3.15 Å R-free 0.294
3BG1 Architecture of a Coat for the Nuclear Pore Membrane Deposited 2007-11-23 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–316（316 aa）
Chain D 1–316（316 aa）
Chain E 1–316（316 aa）
Chain H 1–316（316 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.7；294 K；16 % (w/v) PEG 3,350, 400 mM NaCl, 100 mM Na-K tartrate, and 100 mM BIS-TRIS, pH 7.7, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 3.00 Å R-free 0.294
3BG1 Architecture of a Coat for the Nuclear Pore Membrane Deposited 2007-11-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–316（316 aa）
Chain D 1–316（316 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.7；294 K；16 % (w/v) PEG 3,350, 400 mM NaCl, 100 mM Na-K tartrate, and 100 mM BIS-TRIS, pH 7.7, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 3.00 Å R-free 0.294
3BG1 Architecture of a Coat for the Nuclear Pore Membrane Deposited 2007-11-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 1–316（316 aa）
Chain H 1–316（316 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.7；294 K；16 % (w/v) PEG 3,350, 400 mM NaCl, 100 mM Na-K tartrate, and 100 mM BIS-TRIS, pH 7.7, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 3.00 Å R-free 0.294
3BG1 Architecture of a Coat for the Nuclear Pore Membrane Deposited 2007-11-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–316（316 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.7；294 K；16 % (w/v) PEG 3,350, 400 mM NaCl, 100 mM Na-K tartrate, and 100 mM BIS-TRIS, pH 7.7, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 3.00 Å R-free 0.294
3BG1 Architecture of a Coat for the Nuclear Pore Membrane Deposited 2007-11-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–316（316 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.7；294 K；16 % (w/v) PEG 3,350, 400 mM NaCl, 100 mM Na-K tartrate, and 100 mM BIS-TRIS, pH 7.7, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 3.00 Å R-free 0.294
3BG1 Architecture of a Coat for the Nuclear Pore Membrane Deposited 2007-11-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 1–316（316 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.7；294 K；16 % (w/v) PEG 3,350, 400 mM NaCl, 100 mM Na-K tartrate, and 100 mM BIS-TRIS, pH 7.7, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 3.00 Å R-free 0.294
3BG1 Architecture of a Coat for the Nuclear Pore Membrane Deposited 2007-11-23 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 7 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–316（316 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.7；294 K；16 % (w/v) PEG 3,350, 400 mM NaCl, 100 mM Na-K tartrate, and 100 mM BIS-TRIS, pH 7.7, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 3.00 Å R-free 0.294
5A9Q Human nuclear pore complex Deposited 2015-07-22 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 304 PDB declaration: 304-meric
Chain 6 1–322（322 aa）
Chain F 1–322（322 aa）
Chain O 1–322（322 aa）
Chain X 1–322（322 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20MM TRIS, 0.2-0.4% TREHALOSE；pH 7.5；20MM TRIS, 0.2-0.4% TREHALOSE
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE；VITRIFICATION 1 -- CRYOGEN- ETHANE-PROPANE MIXTURE, INSTRUMENT- HOMEMADE PLUNGER,
Resolution 23.00 Å
7PEQ Model of the outer rings of the human nuclear pore complex Deposited 2021-08-11 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 288 PDB declaration: 288-meric
Chain AF 1–322（322 aa）
Chain BF 1–322（322 aa）
Chain CF 1–322（322 aa）
Chain DF 1–322（322 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；Cells were grown on holey carbon, Au-mesh supports. Grids were rinsed briefly with PBS and manually blotted before plunging into liquid ethane.
Resolution 35.00 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain N0 1–322（322 aa）
Chain N1 1–322（322 aa）
Chain N2 1–322（322 aa）
Chain N3 1–322（322 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å
7UHY Human GATOR2 complex Deposited 2022-03-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain H 1–322（322 aa）
Not recorded ZN ZINC ION × 32 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.66 Å
7UHY Human GATOR2 complex Deposited 2022-03-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain H 1–322（322 aa）
Not recorded ZN ZINC ION × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.66 Å
7UHY Human GATOR2 complex Deposited 2022-03-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain H 1–322（322 aa）
Not recorded ZN ZINC ION × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.66 Å
9LVJ Cryo-EM structure of Sestrin2 bound human GATOR2 complex Deposited 2025-02-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain H 1–368（368 aa）
Chain R 1–368（368 aa）
Not recorded ZN ZINC ION × 32 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.82 Å
9LVK Cryo-EM structure of CASTOR1 bound human GATOR2 complex Deposited 2025-02-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain H 1–368（368 aa）
Chain R 1–368（368 aa）
Not recorded ZN ZINC ION × 31 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.59 Å
9LWF Cryo-EM structure of dual sensor bound GATOR2 complex Deposited 2025-02-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain H 1–368（368 aa）
Chain R 1–368（368 aa）
Not recorded ZN ZINC ION × 32 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.41 Å
9OTI GATOR2 complex bound to arginine sensor CASTOR1 Deposited 2025-05-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain H 1–322（322 aa）
Chain R 1–322（322 aa）
Not recorded ZN ZINC ION × 29 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å

10 other PDB entries and 24 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name SEC13_HUMAN
Isoform —
PDB entities 16
Chains and sequence ranges Author chain N0； PDBConstruct 1–322； UniProt 1–322 Author chain N1； PDBConstruct 1–322； UniProt 1–322 Author chain N2； PDBConstruct 1–322； UniProt 1–322 Author chain N3； PDBConstruct 1–322； UniProt 1–322

Nucleoporin SEH1

OrganismNot specified

UniProt Q96EE3

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain O0； UniProt 1–360 Chain O1； UniProt 1–360 Chain O2； UniProt 1–360 Chain O3； UniProt 1–360 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5A9Q Human nuclear pore complex Deposited 2015-07-22 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 304 PDB declaration: 304-meric
Chain 7 1–360（360 aa）
Chain G 1–360（360 aa）
Chain P 1–360（360 aa）
Chain Y 1–360（360 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20MM TRIS, 0.2-0.4% TREHALOSE；pH 7.5；20MM TRIS, 0.2-0.4% TREHALOSE
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE；VITRIFICATION 1 -- CRYOGEN- ETHANE-PROPANE MIXTURE, INSTRUMENT- HOMEMADE PLUNGER,
Resolution 23.00 Å
7PEQ Model of the outer rings of the human nuclear pore complex Deposited 2021-08-11 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 288 PDB declaration: 288-meric
Chain AG 1–360（360 aa）
Chain BG 1–360（360 aa）
Chain CG 1–360（360 aa）
Chain DG 1–360（360 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；Cells were grown on holey carbon, Au-mesh supports. Grids were rinsed briefly with PBS and manually blotted before plunging into liquid ethane.
Resolution 35.00 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain O0 1–360（360 aa）
Chain O1 1–360（360 aa）
Chain O2 1–360（360 aa）
Chain O3 1–360（360 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å
7UHY Human GATOR2 complex Deposited 2022-03-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain E 1–421（421 aa）
Chain F 1–421（421 aa）
Chain G 1–421（421 aa）
Not recorded ZN ZINC ION × 32 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.66 Å
7UHY Human GATOR2 complex Deposited 2022-03-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain E 1–421（421 aa）
Chain F 1–421（421 aa）
Chain G 1–421（421 aa）
Not recorded ZN ZINC ION × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.66 Å
7UHY Human GATOR2 complex Deposited 2022-03-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain E 1–421（421 aa）
Chain F 1–421（421 aa）
Chain G 1–421（421 aa）
Not recorded ZN ZINC ION × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.66 Å
9LVJ Cryo-EM structure of Sestrin2 bound human GATOR2 complex Deposited 2025-02-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain E 1–421（421 aa）
Chain F 1–421（421 aa）
Chain G 1–421（421 aa）
Chain O 1–421（421 aa）
Chain P 1–421（421 aa）
Chain Q 1–421（421 aa）
Not recorded ZN ZINC ION × 32 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.82 Å
9LVK Cryo-EM structure of CASTOR1 bound human GATOR2 complex Deposited 2025-02-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain E 1–421（421 aa）
Chain F 1–421（421 aa）
Chain G 1–421（421 aa）
Chain O 1–421（421 aa）
Chain P 1–421（421 aa）
Chain Q 1–421（421 aa）
Not recorded ZN ZINC ION × 31 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.59 Å
9LWF Cryo-EM structure of dual sensor bound GATOR2 complex Deposited 2025-02-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain E 1–421（421 aa）
Chain F 1–421（421 aa）
Chain G 1–421（421 aa）
Chain O 1–421（421 aa）
Chain P 1–421（421 aa）
Chain Q 1–421（421 aa）
Not recorded ZN ZINC ION × 32 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.41 Å
9OTI GATOR2 complex bound to arginine sensor CASTOR1 Deposited 2025-05-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain E 1–360（360 aa）
Chain F 1–360（360 aa）
Chain G 1–360（360 aa）
Chain O 1–360（360 aa）
Chain P 1–360（360 aa）
Chain Q 1–360（360 aa）
Not recorded ZN ZINC ION × 29 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å

8 other PDB entries and 10 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name SEH1_HUMAN
Isoform —
PDB entities 17
Chains and sequence ranges Author chain O0； PDBConstruct 1–360； UniProt 1–360 Author chain O1； PDBConstruct 1–360； UniProt 1–360 Author chain O2； PDBConstruct 1–360； UniProt 1–360 Author chain O3； PDBConstruct 1–360； UniProt 1–360

Nuclear pore complex protein Nup85

OrganismNot specified

UniProt Q9BW27

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain P0； UniProt 1–656 Chain P1； UniProt 1–656 Chain P2； UniProt 1–656 Chain P3； UniProt 1–656 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5A9Q Human nuclear pore complex Deposited 2015-07-22 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 304 PDB declaration: 304-meric
Chain 8 1–656（656 aa）
Chain H 1–656（656 aa）
Chain Q 1–656（656 aa）
Chain Z 1–656（656 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20MM TRIS, 0.2-0.4% TREHALOSE；pH 7.5；20MM TRIS, 0.2-0.4% TREHALOSE
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE；VITRIFICATION 1 -- CRYOGEN- ETHANE-PROPANE MIXTURE, INSTRUMENT- HOMEMADE PLUNGER,
Resolution 23.00 Å
7PEQ Model of the outer rings of the human nuclear pore complex Deposited 2021-08-11 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 288 PDB declaration: 288-meric
Chain AH 1–656（656 aa）
Chain BH 1–656（656 aa）
Chain CH 1–656（656 aa）
Chain DH 1–656（656 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；Cells were grown on holey carbon, Au-mesh supports. Grids were rinsed briefly with PBS and manually blotted before plunging into liquid ethane.
Resolution 35.00 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain P0 1–656（656 aa）
Chain P1 1–656（656 aa）
Chain P2 1–656（656 aa）
Chain P3 1–656（656 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

3 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NUP85_HUMAN
Isoform —
PDB entities 18
Chains and sequence ranges Author chain P0； PDBConstruct 1–656； UniProt 1–656 Author chain P1； PDBConstruct 1–656； UniProt 1–656 Author chain P2； PDBConstruct 1–656； UniProt 1–656 Author chain P3； PDBConstruct 1–656； UniProt 1–656

Nucleoporin Nup43

OrganismNot specified

UniProt Q8NFH3

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain Q0； UniProt 1–380 Chain Q1； UniProt 1–380 Chain Q2； UniProt 1–380 Chain Q3； UniProt 1–380 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
4I79 Crystal structure of human NUP43 Deposited 2012-11-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–380（380 aa）
Not recorded UNX UNKNOWN LIGAND × 13 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；291 K；25% PEG-3350, 0.1 M ammonium sulfate, 0.1 M sodium Hepes, pH 7.5, VAPOR DIFFUSION, temperature 291K
Resolution 1.75 Å R-free 0.212
4I79 Crystal structure of human NUP43 Deposited 2012-11-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 1–380（380 aa）
Not recorded UNX UNKNOWN LIGAND × 19 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；291 K；25% PEG-3350, 0.1 M ammonium sulfate, 0.1 M sodium Hepes, pH 7.5, VAPOR DIFFUSION, temperature 291K
Resolution 1.75 Å R-free 0.212
5A9Q Human nuclear pore complex Deposited 2015-07-22 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 304 PDB declaration: 304-meric
Chain 0 1–380（380 aa）
Chain 9 1–380（380 aa）
Chain I 1–380（380 aa）
Chain R 1–380（380 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20MM TRIS, 0.2-0.4% TREHALOSE；pH 7.5；20MM TRIS, 0.2-0.4% TREHALOSE
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE；VITRIFICATION 1 -- CRYOGEN- ETHANE-PROPANE MIXTURE, INSTRUMENT- HOMEMADE PLUNGER,
Resolution 23.00 Å
7PEQ Model of the outer rings of the human nuclear pore complex Deposited 2021-08-11 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 288 PDB declaration: 288-meric
Chain AI 1–380（380 aa）
Chain BI 1–380（380 aa）
Chain CI 1–380（380 aa）
Chain DI 1–380（380 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；Cells were grown on holey carbon, Au-mesh supports. Grids were rinsed briefly with PBS and manually blotted before plunging into liquid ethane.
Resolution 35.00 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain Q0 1–380（380 aa）
Chain Q1 1–380（380 aa）
Chain Q2 1–380（380 aa）
Chain Q3 1–380（380 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

4 other PDB entries and 5 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NUP43_HUMAN
Isoform —
PDB entities 19
Chains and sequence ranges Author chain Q0； PDBConstruct 1–380； UniProt 1–380 Author chain Q1； PDBConstruct 1–380； UniProt 1–380 Author chain Q2； PDBConstruct 1–380； UniProt 1–380 Author chain Q3； PDBConstruct 1–380； UniProt 1–380

Nuclear pore complex protein Nup160

OrganismNot specified

UniProt Q12769

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain R0； UniProt 1–1436 Chain R1； UniProt 1–1436 Chain R2； UniProt 1–1436 Chain R3； UniProt 1–1436 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5A9Q Human nuclear pore complex Deposited 2015-07-22 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 304 PDB declaration: 304-meric
Chain 1 1–1436（1436 aa）
Chain J 1–1436（1436 aa）
Chain S 1–1436（1436 aa）
Chain a 1–1436（1436 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20MM TRIS, 0.2-0.4% TREHALOSE；pH 7.5；20MM TRIS, 0.2-0.4% TREHALOSE
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE；VITRIFICATION 1 -- CRYOGEN- ETHANE-PROPANE MIXTURE, INSTRUMENT- HOMEMADE PLUNGER,
Resolution 23.00 Å
7PEQ Model of the outer rings of the human nuclear pore complex Deposited 2021-08-11 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 288 PDB declaration: 288-meric
Chain AJ 1–1436（1436 aa）
Chain BJ 1–1436（1436 aa）
Chain CJ 1–1436（1436 aa）
Chain DJ 1–1436（1436 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；Cells were grown on holey carbon, Au-mesh supports. Grids were rinsed briefly with PBS and manually blotted before plunging into liquid ethane.
Resolution 35.00 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain R0 1–1436（1436 aa）
Chain R1 1–1436（1436 aa）
Chain R2 1–1436（1436 aa）
Chain R3 1–1436（1436 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

3 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NU160_HUMAN
Isoform —
PDB entities 20
Chains and sequence ranges Author chain R0； PDBConstruct 1–1436； UniProt 1–1436 Author chain R1； PDBConstruct 1–1436； UniProt 1–1436 Author chain R2； PDBConstruct 1–1436； UniProt 1–1436 Author chain R3； PDBConstruct 1–1436； UniProt 1–1436

Nucleoporin Nup37

OrganismNot specified

UniProt Q8NFH4

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain S0； UniProt 1–326 Chain S1； UniProt 1–326 Chain S2； UniProt 1–326 Chain S3； UniProt 1–326 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5A9Q Human nuclear pore complex Deposited 2015-07-22 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 304 PDB declaration: 304-meric
Chain 2 1–326（326 aa）
Chain K 1–326（326 aa）
Chain T 1–326（326 aa）
Chain b 1–326（326 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20MM TRIS, 0.2-0.4% TREHALOSE；pH 7.5；20MM TRIS, 0.2-0.4% TREHALOSE
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE；VITRIFICATION 1 -- CRYOGEN- ETHANE-PROPANE MIXTURE, INSTRUMENT- HOMEMADE PLUNGER,
Resolution 23.00 Å
7PEQ Model of the outer rings of the human nuclear pore complex Deposited 2021-08-11 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 288 PDB declaration: 288-meric
Chain AK 1–326（326 aa）
Chain BK 1–326（326 aa）
Chain CK 1–326（326 aa）
Chain DK 1–326（326 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；Cells were grown on holey carbon, Au-mesh supports. Grids were rinsed briefly with PBS and manually blotted before plunging into liquid ethane.
Resolution 35.00 Å
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain S0 1–326（326 aa）
Chain S1 1–326（326 aa）
Chain S2 1–326（326 aa）
Chain S3 1–326（326 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

3 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NUP37_HUMAN
Isoform —
PDB entities 21
Chains and sequence ranges Author chain S0； PDBConstruct 1–326； UniProt 1–326 Author chain S1； PDBConstruct 1–326； UniProt 1–326 Author chain S2； PDBConstruct 1–326； UniProt 1–326 Author chain S3； PDBConstruct 1–326； UniProt 1–326

Protein ELYS

OrganismNot specified

UniProt Q8WYP5

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain T0； UniProt 1–2266 Chain T1； UniProt 1–2266 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain T0 1–2266（2266 aa）
Chain T1 1–2266（2266 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

1 other PDB entries and 1 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name ELYS_HUMAN
Isoform —
PDB entities 22
Chains and sequence ranges Author chain T0； PDBConstruct 1–2266； UniProt 1–2266 Author chain T1； PDBConstruct 1–2266； UniProt 1–2266

Nuclear pore complex protein Nup214

OrganismNot specified

UniProt P35658

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain V0； UniProt 1–2090 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup88 × 8 （Q99567） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
3FHC Crystal structure of human Dbp5 in complex with Nup214 Deposited 2008-12-09 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–405（405 aa） Fragment：Nterminal beta propeller, UNP residues 1-405
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；50mM MES pH 6.0, 900mM Na citrate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.80 Å R-free 0.260
3FMO Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19 Deposited 2008-12-22 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–450（450 aa）
Not recorded GOL GLYCEROL × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；298 K；sodium di-hydrogen phosphate, di-potassium hydrogen phosphate, sodium acetate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.51 Å R-free 0.242
3FMP Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19 Deposited 2008-12-22 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–450（450 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；298 K；PEG 3000, CHES buffer, pH 9.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 3.19 Å R-free 0.283
3FMP Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19 Deposited 2008-12-22 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–450（450 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；298 K；PEG 3000, CHES buffer, pH 9.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 3.19 Å R-free 0.283
5DIS Crystal structure of a CRM1-RanGTP-SPN1 export complex bound to a 113 amino acid FG-repeat containing fragment of Nup214 Deposited 2015-09-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 1916–2027（112 aa）
Not recorded PRO PROLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；5% PEG 8000, 0.2M L-proline, 0.1M Tris pH 7.5, 4 mM D-maltose, 180 mM LiCl
Resolution 2.85 Å R-free 0.249
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain V0 1–2090（2090 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

5 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NU214_HUMAN
Isoform —
PDB entities 24
Chains and sequence ranges Author chain V0； PDBConstruct 1–2090； UniProt 1–2090

Nuclear pore complex protein Nup88

OrganismNot specified

UniProt Q99567

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 808 PDB declaration: 808-meric（808） Consistent with protein copy count Chain W0； UniProt 1–741 Not recorded E3 SUMO-protein ligase RanBP2 × 40 （P49792） Nuclear pore membrane glycoprotein 210 × 64 （Q8TEM1） Aladin × 16 （Q9NRG9） Nuclear pore complex protein Nup93 × 56 （Q8N1F7） Nucleoporin NUP188 homolog × 16 （Q5SRE5） Nuclear pore complex protein Nup205 × 40 （Q92621） Nuclear pore complex protein Nup155 × 48 （O75694） Nucleoporin NDC1 × 16 （Q9BTX1） Nucleoporin NUP35 × 32 （Q8NFH5） Nucleoporin p54 × 32 （Q7Z3B4） Nucleoporin p58/p45 × 32 （Q9BVL2） Nuclear pore glycoprotein p62 × 40 （P37198） Nuclear pore complex protein Nup133 × 32 （Q8WUM0） Nuclear pore complex protein Nup107 × 32 （P57740） Nuclear pore complex protein Nup96 × 32 （P52948） Protein SEC13 homolog × 32 （P55735） Nucleoporin SEH1 × 32 （Q96EE3） Nuclear pore complex protein Nup85 × 32 （Q9BW27） Nucleoporin Nup43 × 32 （Q8NFH3） Nuclear pore complex protein Nup160 × 32 （Q12769） Nucleoporin Nup37 × 32 （Q8NFH4） Protein ELYS × 16 （Q8WYP5） Nuclear pore complex protein Nup98 × 56 （P52948） Nuclear pore complex protein Nup214 × 8 （P35658） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE-PROPANE Resolution 50.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R5J Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
7MNI Crystal structure of the N-terminal domain of NUP88 in complex with NUP98 C-terminal Autoproteolytic Domain Deposited 2021-05-01 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–493（493 aa） Fragment：N-terminal domain of NUP88 (UNP residues 1-493)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.3；294 K；20% w/v PEG4000, 0.22 M sodium chloride, 0.1 M Tris
Resolution 2.00 Å R-free 0.208
7MNI Crystal structure of the N-terminal domain of NUP88 in complex with NUP98 C-terminal Autoproteolytic Domain Deposited 2021-05-01 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–493（493 aa） Fragment：N-terminal domain of NUP88 (UNP residues 1-493)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.3；294 K；20% w/v PEG4000, 0.22 M sodium chloride, 0.1 M Tris
Resolution 2.00 Å R-free 0.208
7R5K Human nuclear pore complex (constricted) Deposited 2022-02-10 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 808 PDB declaration: 808-meric
Chain W0 1–741（741 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.00 Å

2 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NUP88_HUMAN
Isoform —
PDB entities 25
Chains and sequence ranges Author chain W0； PDBConstruct 1–741； UniProt 1–741

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 7r5j

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 7r5j
Download Download
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2. Structure Basics 2. Structure Basics

Entry ID entry_id7r5j
Deposition date deposition_date2022-02-10
Structure title titleHuman nuclear pore complex (dilated)
Keywords keywordsnucleocytoplasmic transport, multiprotein complex, TRANSPORT PROTEIN; TRANSPORT PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier— Å
Radius of gyration Rg (electron density) rg_electron260.30 Å
Forward intensity I(0) i01019850000000.00
Molecular weight molecular_weight8770700.0 kDa
Excluded volume excluded_volume11015000 ų
Envelope volume envelope_volume38907000 ų
Hydration-shell volume shell_volume1280400 ų
Envelope diameter envelope_diameter911.4 Å
Shell Rg shell_rg209.70 Å
Envelope Rg envelope_rg246.20 Å
Shape Rg shape_rg260.30 Å
Total Rg total_rg260.00 Å
Total atoms total_atoms617133
Residues n_residues78030
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax786.2 Å
Rg (real space) rg_real308.20 Å
Rg uncertainty (real space) rg_real_error2.96 Å
I(0) (real space) i0_real1.1290e+12
I(0) uncertainty (real space) i0_real_error2.8290e+10
Rg (reciprocal space) rg_reciprocal154.70 Å
I(0) (reciprocal space) i0_reciprocal540500000000.0000
Solution quality estimate total_estimate0.8550
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks2
Primary peak position r_peak_primary262.1 Å
Skewness Skewness skewness0.072
Kurtosis Kurtosis kurtosis-1.304
Angular range angular_range— – 0.0300 Å−1
Current regularization parameter α current_alpha1.7810
Highest regularization parameter α highest_alpha14240000000.0000
Real-space data points n_real_points7
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 21.210; Oscil: 0.919; Stabil: 0.915; Sysdev: 1.000; Positv: 1.000; Valcen: 0.009; Smooth: 0.608
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (25)

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8. Citations (1)

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9. Files and Curves (10)