8rc0

Structure of the human 20S U5 snRNP

Method: ELECTRON MICROSCOPY
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

CD2 antigen cytoplasmic tail-binding protein 2

Homo sapiens

UniProt O95400

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 14 RNA 1 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 Pre-mRNA-processing factor 6 × 1 (O94906) Probable ATP-dependent RNA helicase DDX23 × 1 (Q9BUQ8) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) GUANOSINE-5'-TRIPHOSPHATE × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CD2B2_HUMAN
Isoform —
PDB实体 1
链与序列区间 作者链 F; PDB构建体 1–341; UniProt 1–341

Pre-mRNA-processing-splicing factor 8

物种未注明

UniProt Q6P2Q9

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 14 RNA 1 CD2 antigen cytoplasmic tail-binding protein 2 × 1 (O95400) U5 snRNA × 1 Pre-mRNA-processing factor 6 × 1 (O94906) Probable ATP-dependent RNA helicase DDX23 × 1 (Q9BUQ8) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) GUANOSINE-5'-TRIPHOSPHATE × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 PRP8_HUMAN
Isoform —
PDB实体 2
链与序列区间 作者链 A; PDB构建体 1–2335; UniProt 1–2335

Pre-mRNA-processing factor 6

物种未注明

UniProt O94906

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 14 RNA 1 CD2 antigen cytoplasmic tail-binding protein 2 × 1 (O95400) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 Probable ATP-dependent RNA helicase DDX23 × 1 (Q9BUQ8) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) GUANOSINE-5'-TRIPHOSPHATE × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 PRP6_HUMAN
Isoform —
PDB实体 4
链与序列区间 作者链 E; PDB构建体 1–941; UniProt 1–941

Probable ATP-dependent RNA helicase DDX23

Homo sapiens

UniProt Q9BUQ8

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 14 RNA 1 CD2 antigen cytoplasmic tail-binding protein 2 × 1 (O95400) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 Pre-mRNA-processing factor 6 × 1 (O94906) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) GUANOSINE-5'-TRIPHOSPHATE × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DDX23_HUMAN
Isoform —
PDB实体 5
链与序列区间 作者链 D; PDB构建体 1–820; UniProt 1–820

U5 small nuclear ribonucleoprotein 40 kDa protein

Homo sapiens

UniProt Q96DI7

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 14 RNA 1 CD2 antigen cytoplasmic tail-binding protein 2 × 1 (O95400) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 Pre-mRNA-processing factor 6 × 1 (O94906) Probable ATP-dependent RNA helicase DDX23 × 1 (Q9BUQ8) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) GUANOSINE-5'-TRIPHOSPHATE × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 SNR40_HUMAN
Isoform —
PDB实体 6
链与序列区间 作者链 G; PDB构建体 1–357; UniProt 1–357

U5 small nuclear ribonucleoprotein 200 kDa helicase

物种未注明

UniProt O75643

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 14 RNA 1 CD2 antigen cytoplasmic tail-binding protein 2 × 1 (O95400) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 Pre-mRNA-processing factor 6 × 1 (O94906) Probable ATP-dependent RNA helicase DDX23 × 1 (Q9BUQ8) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) GUANOSINE-5'-TRIPHOSPHATE × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 U520_HUMAN
Isoform —
PDB实体 7
链与序列区间 作者链 B; PDB构建体 1–60; UniProt 1–60 作者链 B; PDB构建体 61–2136; UniProt 61–2136

Small nuclear ribonucleoprotein Sm D1

Homo sapiens

UniProt P62314

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 14 RNA 1 CD2 antigen cytoplasmic tail-binding protein 2 × 1 (O95400) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 Pre-mRNA-processing factor 6 × 1 (O94906) Probable ATP-dependent RNA helicase DDX23 × 1 (Q9BUQ8) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) GUANOSINE-5'-TRIPHOSPHATE × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 SMD1_HUMAN
Isoform —
PDB实体 8
链与序列区间 作者链 i; PDB构建体 1–119; UniProt 1–119

Small nuclear ribonucleoprotein Sm D3

Homo sapiens

UniProt P62318

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 14 RNA 1 CD2 antigen cytoplasmic tail-binding protein 2 × 1 (O95400) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 Pre-mRNA-processing factor 6 × 1 (O94906) Probable ATP-dependent RNA helicase DDX23 × 1 (Q9BUQ8) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) GUANOSINE-5'-TRIPHOSPHATE × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 SMD3_HUMAN
Isoform —
PDB实体 9
链与序列区间 作者链 k; PDB构建体 1–126; UniProt 1–126

Small nuclear ribonucleoprotein E

Homo sapiens

UniProt P62304

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 14 RNA 1 CD2 antigen cytoplasmic tail-binding protein 2 × 1 (O95400) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 Pre-mRNA-processing factor 6 × 1 (O94906) Probable ATP-dependent RNA helicase DDX23 × 1 (Q9BUQ8) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) GUANOSINE-5'-TRIPHOSPHATE × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RUXE_HUMAN
Isoform —
PDB实体 10
链与序列区间 作者链 l; PDB构建体 1–92; UniProt 1–92

Small nuclear ribonucleoprotein F

Homo sapiens

UniProt P62306

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 14 RNA 1 CD2 antigen cytoplasmic tail-binding protein 2 × 1 (O95400) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 Pre-mRNA-processing factor 6 × 1 (O94906) Probable ATP-dependent RNA helicase DDX23 × 1 (Q9BUQ8) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein G × 1 (P62308) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) GUANOSINE-5'-TRIPHOSPHATE × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RUXF_HUMAN
Isoform —
PDB实体 11
链与序列区间 作者链 m; PDB构建体 1–86; UniProt 1–86

Small nuclear ribonucleoprotein G

Homo sapiens

UniProt P62308

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 14 RNA 1 CD2 antigen cytoplasmic tail-binding protein 2 × 1 (O95400) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 Pre-mRNA-processing factor 6 × 1 (O94906) Probable ATP-dependent RNA helicase DDX23 × 1 (Q9BUQ8) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) GUANOSINE-5'-TRIPHOSPHATE × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RUXG_HUMAN
Isoform —
PDB实体 12
链与序列区间 作者链 n; PDB构建体 1–76; UniProt 1–76

Small nuclear ribonucleoprotein Sm D2

Homo sapiens

UniProt P62316

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 14 RNA 1 CD2 antigen cytoplasmic tail-binding protein 2 × 1 (O95400) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 Pre-mRNA-processing factor 6 × 1 (O94906) Probable ATP-dependent RNA helicase DDX23 × 1 (Q9BUQ8) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) GUANOSINE-5'-TRIPHOSPHATE × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 SMD2_HUMAN
Isoform —
PDB实体 13
链与序列区间 作者链 j; PDB构建体 1–118; UniProt 1–118

;Small nuclear ribonucleoprotein-associated proteins B and B' ;

Homo sapiens

UniProt P14678

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 14 RNA 1 CD2 antigen cytoplasmic tail-binding protein 2 × 1 (O95400) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 Pre-mRNA-processing factor 6 × 1 (O94906) Probable ATP-dependent RNA helicase DDX23 × 1 (Q9BUQ8) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) GUANOSINE-5'-TRIPHOSPHATE × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RSMB_HUMAN
Isoform —
PDB实体 14
链与序列区间 作者链 h; PDB构建体 1–240; UniProt 1–240

116 kDa U5 small nuclear ribonucleoprotein component

Homo sapiens

UniProt Q15029

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 14 RNA 1 CD2 antigen cytoplasmic tail-binding protein 2 × 1 (O95400) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) U5 snRNA × 1 Pre-mRNA-processing factor 6 × 1 (O94906) Probable ATP-dependent RNA helicase DDX23 × 1 (Q9BUQ8) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 (O75643) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) GUANOSINE-5'-TRIPHOSPHATE × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 U5S1_HUMAN
Isoform —
PDB实体 15
链与序列区间 作者链 C; PDB构建体 1–972; UniProt 1–972

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id8rc0
沉积日期 deposition_date2023-12-05
结构标题 titleStructure of the human 20S U5 snRNP
关键词 keywordssnRNP, CD2BP2, spliceosome, U5, SPLICING; SPLICING
实验方法 methodELECTRON MICROSCOPY
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

8rc0__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

8rc0__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

8rc0__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)74.87 Å
Rg(电子密度)70.64 Å
总 Rg69.72 Å
原子数40620
残基数6498
排除体积665420 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 8rc0__assembly_1__model_1 15-meric (15) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (16)

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7. 引用文献 (1)