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9bcj

Crystal structure of human hemoglobin in complex with the HbpA receptor from Corynebacterium diphtheriae

Method: X-RAY DIFFRACTION Dmax: 93.0 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Hemoglobin subunit alpha

OrganismNot specified

UniProt P69905

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 6 PDB declaration: hexameric（6） Consistent with protein copy count Chain A； UniProt 2–142 Not recorded Hemoglobin subunit beta × 2 （P68871） Membrane protein × 2 （Q6NEE5） HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 6 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；20% PEG-2000 MME, 100 mM Tris, 240 mM TMAO Resolution 1.69 Å R-free 0.215

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9BCJ Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1A00 HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 TYR) MUTANT Deposited 1997-12-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；10.5% PEG 6000 10 MM POTASSIUM PHOSPHATE PH 7.0 100 MM POTASSIUM CHLORIDE 3 MM SODIUM DITHIONITE
Resolution 2.00 Å R-free 0.223
1A01 HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 ALA) MUTANT Deposited 1997-12-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；2.3 M AMMONIUM SULFATE 0.3 M AMMONIUM PHOSPHATE PH 6.5 10 MM FERROUS CITRATE
Resolution 1.80 Å R-free 0.223
1A0U HEMOGLOBIN (VAL BETA1 MET) MUTANT Deposited 1997-12-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；10.5% PEG 6000 10 MM POTASSIUM PHOSPHATE PH 7.0 100 MM POTASSIUM CHLORIDE 3 MM SODIUM DITHIONITE
Resolution 2.14 Å R-free 0.239
1A0Z HEMOGLOBIN (VAL BETA1 MET) MUTANT Deposited 1997-12-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；10.5% PEG 6000 10 MM POTASSIUM PHOSPHATE PH 7.0 100 MM POTASSIUM CHLORIDE 3 MM SODIUM DITHIONITE
Resolution 2.00 Å
1A3N DEOXY HUMAN HEMOGLOBIN Deposited 1998-01-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.220
1A3O ARTIFICIAL MUTANT (ALPHA Y42H) OF DEOXY HEMOGLOBIN Deposited 1998-01-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：CHAIN A, C, Y42H Mutation：CHAIN A, C, Y42H HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
1A9W HUMAN EMBRYONIC GOWER II CARBONMONOXY HEMOGLOBIN Deposited 1998-04-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions microseeding and macroseeding used to increase crystal size；pH 8.5；PROTEIN WAS CRYSTALLIZED FROM 21% MME-PEG 5000, 0.2M TAPS/ KOH, PH 8.5, 2MM DITHIONITE. THEN MICROSEEDING AND MACROSEEDING USED TO INCREASE CRYSTAL SIZE, microseeding and macroseeding used to increase crystal size
Resolution 2.90 Å R-free 0.232
1ABW DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN) Deposited 1997-01-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–141（141 aa）
Mutation：CHAIN A IS COMPOSED OF TWO COPIES OF HEMOGLOBIN ALPHA CHAIN JOINED BY AN ADDITIONAL RESIDUE, GLY 142 MET METHIONINE × 2 LEU LEUCINE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.2；pH 6.2
Resolution 2.00 Å R-free 0.232
1ABY CYANOMET RHB1.1 (RECOMBINANT HEMOGLOBIN) Deposited 1997-01-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–141（141 aa）
Mutation：CHAIN A, V1M, CHAIN B, D, V1M, N108K CYN CYANIDE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5；pH 5.0
Resolution 2.60 Å R-free 0.278
1AJ9 R-STATE HUMAN CARBONMONOXYHEMOGLOBIN ALPHA-A53S Deposited 1997-05-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Mutation：A53S PO4 PHOSPHATE ION × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch method；pH 6.7；PROTEIN WAS BATCH CRYSTALLIZED IN 2.5 M SODIUM/POTASSIUM PHOSPHATE, PH 6.7, AND 1% (W/V) CARBOXYHEMOGLOBIN., batch method
Resolution 2.20 Å
1B86 HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX Deposited 1999-02-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 DG2 (2R)-2,3-diphosphoglyceric acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.2
Resolution 2.50 Å
1BAB HEMOGLOBIN THIONVILLE: AN ALPHA-CHAIN VARIANT WITH A SUBSTITUTION OF A GLUTAMATE FOR VALINE AT NA-1 AND HAVING AN ACETYLATED METHIONINE NH2 TERMINUS Deposited 1992-05-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–141（140 aa）
Chain C 2–141（140 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
1BBB A THIRD QUATERNARY STRUCTURE OF HUMAN HEMOGLOBIN A AT 1.7-ANGSTROMS RESOLUTION Deposited 1992-04-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.70 Å
1BIJ CROSSLINKED, DEOXY HUMAN HEMOGLOBIN A Deposited 1998-06-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；pH 7.0
Resolution 2.30 Å R-free 0.263
1BUW CRYSTAL STRUCTURE OF S-NITROSO-NITROSYL HUMAN HEMOGLOBIN A Deposited 1998-09-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NO NITRIC OXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；1% PROTEIN 100 MM SODIUM CACODYLATE, PH 5.8 16% PEG 6000
Resolution 1.90 Å R-free 0.244
1BZ0 HEMOGLOBIN A (HUMAN, DEOXY, HIGH SALT) Deposited 1998-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；2.3 M AMMONIUM SULFATE 0.3 M AMMONIUM PHOSPHATE PH 6.5 10 MM FERROUS CITRATE
Resolution 1.50 Å R-free 0.208
1BZ1 HEMOGLOBIN (ALPHA + MET) VARIANT Deposited 1998-11-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；2.3 M AMMONIUM SULFATE 0.3 M AMMONIUM PHOSPHATE PH 6.5 10 MM FERROUS CITRATE
Resolution 1.59 Å R-free 0.224
1BZZ HEMOGLOBIN (ALPHA V1M) MUTANT Deposited 1998-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：V1M Mutation：V1M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；2.3 M AMMONIUM SULFATE 0.3 M AMMONIUM PHOSPHATE PH 6.5 10 MM FERROUS CITRATE, pH 7.0
Resolution 1.59 Å R-free 0.214
1C7B DEOXY RHB1.0 (RECOMBINANT HEMOGLOBIN) Deposited 2000-02-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：V1M Mutation：V1M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；PERUTZ, J.CRYST.GROWTH 2(1968)54-56, pH 6.5
Resolution 1.80 Å R-free 0.234
1C7C DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN) Deposited 2000-02-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–141（141 aa）
Mutation：V1M,142G HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；PERUTZ, J.CRYST.GROWTH 2(1968)54-56, pH 6.5
Resolution 1.80 Å R-free 0.227
1C7D DEOXY RHB1.2 (RECOMBINANT HEMOGLOBIN) Deposited 2000-02-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–141（141 aa）
Mutation：V1M,142G,143G HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；PERUTZ, J.CRYST.GROWTH 2(1968)54-56, pH 6.5
Resolution 1.80 Å R-free 0.240
1CLS CROSS-LINKED HUMAN HEMOGLOBIN DEOXY Deposited 1995-08-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 O OXYGEN ATOM × 2 SO4 SULFATE ION × 2 DEC SEBACIC ACID × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å
1CMY THE MUTATION BETA99 ASP-TYR STABILIZES Y-A NEW, COMPOSITE QUATERNARY STATE OF HUMAN HEMOGLOBIN Deposited 1992-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 3.00 Å
1COH STRUCTURE OF HAEMOGLOBIN IN THE DEOXY QUATERNARY STATE WITH LIGAND BOUND AT THE ALPHA HAEMS Deposited 1989-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 COH PROTOPORPHYRIN IX CONTAINING CO × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.90 Å
1DKE NI BETA HEME HUMAN HEMOGLOBIN Deposited 1999-12-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；294 K；24 MG/ML PROTEIN 21% PEG 1000 10MM POTASSIUM PHOSPHATE, 1MM IHP, 30MM SODIUM DITHIONITE, pH 7, VAPOR DIFFUSION, HANGING DROP
Resolution 2.10 Å R-free 0.280
1DXT HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI Deposited 1992-05-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.70 Å
1DXU HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI Deposited 1992-05-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.70 Å
1DXV HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI Deposited 1992-05-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.70 Å
1FDH STRUCTURE OF HUMAN FOETAL DEOXYHAEMOGLOBIN Deposited 1976-08-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain B 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å
1FN3 CRYSTAL STRUCTURE OF NICKEL RECONSTITUTED HEMOGLOBIN-A CASE FOR PERMANENT, T-STATE HEMOGLOBIN Deposited 2000-08-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.20
Resolution 2.48 Å R-free 0.324
1G9V HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXY HEMOGLOBIN COMPLEXED WITH A POTENT ALLOSTERIC EFFECTOR Deposited 2000-11-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 RQ3 2-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID × 2 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；Ammonium sulfate, ammonium phosphate, ferrous citrate, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 1.85 Å R-free 0.208
1GBU DEOXY (BETA-(C93A,C112G)) HUMAN HEMOGLOBIN Deposited 1996-01-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：CHAIN B, D, C93A, C112G Mutation：CHAIN B, D, C93A, C112G HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1GBV (ALPHA-OXY, BETA-(C112G)DEOXY) T-STATE HUMAN HEMOGLOBIN Deposited 1995-12-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：CHAIN B, D, C112G Mutation：CHAIN B, D, C112G HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å
1GLI DEOXYHEMOGLOBIN T38W (ALPHA CHAINS), V1G (ALPHA AND BETA CHAINS) Deposited 1996-02-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–141（140 aa）
Chain C 2–141（140 aa）
Mutation：V1M, CHAIN A, C, T38W Mutation：V1M, CHAIN A, C, T38W HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å
1GZX Oxy T State Haemoglobin - Oxygen bound at all four haems Deposited 2002-06-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；BATCH CRYSTALLISATION, OXYHB (75-90 MG/ML) IN 50MM POTASSIUM PHOSPHATE (PH 7.2), 22-28% PEG 8000 AND A 5 MOLAR EXCESS OF THE ALLOSTERIC EFFECTOR IHP
Resolution 2.10 Å R-free 0.221
1HAB CROSSLINKED HAEMOGLOBIN Deposited 1996-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 CIN 4-CARBOXYCINNAMIC ACID × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.30 Å
1HAC CROSSLINKED HAEMOGLOBIN Deposited 1996-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 NDD 2,6-DICARBOXYNAPHTHALENE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å
1HBA HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE Deposited 1992-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CL CHLORIDE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å
1HBB HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE Deposited 1992-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å
1HBS REFINED CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S. I. RESTRAINED LEAST-SQUARES REFINEMENT AT 3.0-ANGSTROMS RESOLUTION Deposited 1982-06-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 3.00 Å
1HBS REFINED CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S. I. RESTRAINED LEAST-SQUARES REFINEMENT AT 3.0-ANGSTROMS RESOLUTION Deposited 1982-06-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 1–141（141 aa）
Chain G 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 3.00 Å
1HCO THE STRUCTURE OF HUMAN CARBONMONOXY HAEMOGLOBIN AT 2.7 ANGSTROMS RESOLUTION Deposited 1979-08-07 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å
1HGA HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN Deposited 1991-10-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å
1HGB HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN Deposited 1991-10-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å
1HGC HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN Deposited 1991-10-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å
1HHO STRUCTURE OF HUMAN OXYHAEMOGLOBIN AT 2.1 ANGSTROMS RESOLUTION Deposited 1983-06-10 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded PO4 PHOSPHATE ION × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å
1IRD Crystal Structure of Human Carbonmonoxy-Haemoglobin at 1.25 A Resolution Deposited 2001-09-27 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.7；298 K；potassium phosphate, pH 6.7, SMALL TUBES, temperature 298K
Resolution 1.25 Å R-free 0.214
1J3Y Direct observation of photolysis-induced tertiary structural changes in human hemoglobin; Crystal structure of alpha(Fe)-beta(Ni) hemoglobin (laser photolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, SMALL TUBES, temperature 293K, pH 6.60
Resolution 1.55 Å R-free 0.205
1J3Y Direct observation of photolysis-induced tertiary structural changes in human hemoglobin; Crystal structure of alpha(Fe)-beta(Ni) hemoglobin (laser photolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 1–141（141 aa）
Chain G 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, SMALL TUBES, temperature 293K, pH 6.60
Resolution 1.55 Å R-free 0.205
1J3Z Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Fe-CO)-beta(Ni) hemoglobin (laser unphotolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, SMALL TUBES, temperature 293K, pH 6.60
Resolution 1.60 Å R-free 0.196
1J3Z Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Fe-CO)-beta(Ni) hemoglobin (laser unphotolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 1–141（141 aa）
Chain G 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, SMALL TUBES, temperature 293K, pH 6.60
Resolution 1.60 Å R-free 0.196
1J40 Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe-CO) hemoglobin (laser unphotolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, pH 6.6, SMALL TUBES, temperature 293K
Resolution 1.45 Å R-free 0.197
1J40 Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe-CO) hemoglobin (laser unphotolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 1–141（141 aa）
Chain G 1–141（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, pH 6.6, SMALL TUBES, temperature 293K
Resolution 1.45 Å R-free 0.197
1J41 Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe) hemoglobin (laser photolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, pH 6.6, SMALL TUBES, temperature 293K
Resolution 1.45 Å R-free 0.195
1J41 Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe) hemoglobin (laser photolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 1–141（141 aa）
Chain G 1–141（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 3 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, pH 6.6, SMALL TUBES, temperature 293K
Resolution 1.45 Å R-free 0.195
1J7S Crystal Structure of deoxy HbalphaYQ, a mutant of HbA Deposited 2001-05-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa） Fragment：alpha chain
Chain C 1–141（141 aa） Fragment：alpha chain
Mutation：V1M,L29Y,H54Q Mutation：V1M,L29Y,H54Q HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.7；293 K；Ammonium sulphate, ammonium phosphate, pH 6.7, SMALL TUBES, temperature 293K
Resolution 2.20 Å R-free 0.210
1J7W Crystal structure of deoxy HbbetaYQ, a site directed mutant of HbA Deposited 2001-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa） Fragment：alpha chain
Chain C 1–141（141 aa） Fragment：alpha chain
Mutation：V1M Mutation：V1M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.7；298 K；ammonium sulphate, ammonium phosphate, pH 6.7, SMALL TUBES, temperature 298.0K
Resolution 2.00 Å R-free 0.223
1J7Y Crystal structure of partially ligated mutant of HbA Deposited 2001-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa） Fragment：alpha chain
Chain C 1–141（141 aa） Fragment：alpha chain
Mutation：V1M, L29Y, H54Q Mutation：V1M, L29Y, H54Q HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 CMO CARBON MONOXIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.7；298 K；ammonium sulphate, ammonium phosphate, pH 6.7, SMALL TUBES, temperature 298.0K
Resolution 1.70 Å R-free 0.201
1JY7 THE STRUCTURE OF HUMAN METHEMOGLOBIN. THE VARIATION OF A THEME Deposited 2001-09-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；293 K；PEG 4000, Sodium potassium phosphate, pH 6.7, LIQUID DIFFUSION at 293K
Resolution 3.20 Å R-free 0.245
1JY7 THE STRUCTURE OF HUMAN METHEMOGLOBIN. THE VARIATION OF A THEME Deposited 2001-09-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain P 1–141（141 aa）
Chain R 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；293 K；PEG 4000, Sodium potassium phosphate, pH 6.7, LIQUID DIFFUSION at 293K
Resolution 3.20 Å R-free 0.245
1JY7 THE STRUCTURE OF HUMAN METHEMOGLOBIN. THE VARIATION OF A THEME Deposited 2001-09-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain U 1–141（141 aa）
Chain W 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；293 K；PEG 4000, Sodium potassium phosphate, pH 6.7, LIQUID DIFFUSION at 293K
Resolution 3.20 Å R-free 0.245
1K0Y X-ray Crystallographic Analyses of Symmetrical Allosteric Effectors of Hemoglobin. Compounds Designed to Link Primary and Secondary Binding Sites Deposited 2001-09-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 CNO 2-{4-[(3{2-[4-(1-CARBOXY-1-METHYL-ETHOXY)-PHENYL]-ACETYLAMINO}-PHENYLCARBAMOYL)-METHYL]-PHENOXY}-2-METHYL-PROPIONIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；Ammonium sulfate, ammonium phosphate, ferrous citrate, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 1.87 Å R-free 0.189
1K1K Structure of Mutant Human Carbonmonoxyhemoglobin C (beta E6K) at 2.0 Angstrom Resolution in Phosphate Buffer. Deposited 2001-09-25 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch method；pH 7.35；310 K；potassium phosphate 1.75M, pH 7.35, batch method, temperature 310K
Resolution 2.00 Å R-free 0.238
1KD2 Crystal Structure of Human Deoxyhemoglobin in Absence of Any Anions Deposited 2001-11-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH METHOD；pH 7；298 K；DEIONIZED PEG 3350 12.5%, pH 7.0, BATCH METHOD, temperature 298K
Resolution 1.87 Å R-free 0.250
1LFL DEOXY HEMOGLOBIN (90% RELATIVE HUMIDITY) Deposited 2002-04-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
Resolution 2.70 Å R-free 0.263
1LFL DEOXY HEMOGLOBIN (90% RELATIVE HUMIDITY) Deposited 2002-04-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain P 1–141（141 aa）
Chain R 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
Resolution 2.70 Å R-free 0.263
1LFQ OXY HEMOGLOBIN (93% RELATIVE HUMIDITY) Deposited 2002-04-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
Resolution 2.60 Å R-free 0.258
1LFT OXY HEMOGLOBIN (90% RELATIVE HUMIDITY) Deposited 2002-04-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
Resolution 2.60 Å R-free 0.265
1LFV OXY HEMOGLOBIN (88% RELATIVE HUMIDITY) Deposited 2002-04-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
Resolution 2.80 Å R-free 0.270
1LFY OXY HEMOGLOBIN (84% RELATIVE HUMIDITY) Deposited 2002-04-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
Resolution 3.30 Å R-free 0.261
1LFZ OXY HEMOGLOBIN (25% METHANOL) Deposited 2002-04-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
Resolution 3.10 Å R-free 0.268
1LJW Crystal Structure of Human Carbonmonoxy Hemoglobin at 2.16 A: A Snapshot of the Allosteric Transition Deposited 2002-04-22 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.4；298 K；Potassium phosphate, Sodium phosphate, toluene, hemoglobin, pH 6.4, LIQUID DIFFUSION, temperature 298K
Resolution 2.16 Å R-free 0.259
1M9P Crystalline Human Carbonmonoxy Hemoglobin C Exhibits The R2 Quaternary State at Neutral pH In The Presence of Polyethylene Glycol: The 2.1 Angstrom Resolution Crystal Structure Deposited 2002-07-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.1；298 K；21% Polyethylene glycol, 0.150M HEPES-Na, chloride anion traces, pH 7.1, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.10 Å R-free 0.269
1MKO A Fourth Quaternary Structure of Human Hemoglobin A at 2.18 A Resolution Deposited 2002-08-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded PO4 PHOSPHATE ION × 3 CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.4；298 K；potassium and sodium phosphate, toluene, hemoglobin, pH 6.4, LIQUID DIFFUSION at 298K
Resolution 2.18 Å R-free 0.284
1NEJ Crystalline Human Carbonmonoxy Hemoglobin S (Liganded Sickle Cell Hemoglobin) Exhibits The R2 Quaternary State At Neutral pH In The Presence Of Polyethylene Glycol: The 2.1 Angstrom Resolution Crystal Structure Deposited 2002-12-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa） Fragment：alpha chain
Chain C 1–141（141 aa） Fragment：alpha chain
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.1；298 K；25% PEG 4000, 0.15M HEPES-Na,chloride anion traces; pH 7.1, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 298K
Resolution 2.10 Å R-free 0.268
1NIH Structure of deoxy-quaternary haemoglobin with liganded beta subunits Deposited 1990-03-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 IHP INOSITOL HEXAKISPHOSPHATE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å
1NQP Crystal structure of Human hemoglobin E at 1.73 A resolution Deposited 2003-01-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric
Chain not uniquely mapped Reference range not declared
Chain A 1–141（141 aa）
Not recorded CYN CYANIDE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；PEG and Glycerol, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 1.73 Å R-free 0.211
1O1I Cyanomet hemoglobin (A-GLY-C:V1M,L29F,H58Q; B,D:V1M,L106W) Deposited 2002-11-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Mutation：V1M, L29F, H58Q CYN CYANIDE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；pH 6.70
Resolution 2.30 Å R-free 0.267
1O1J Deoxy hemoglobin (A-GLY-C:V1M,L29F,H58Q; B,D:V1M,L106W) Deposited 2002-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–141（141 aa）
Mutation：V1M, L29F, H58Q HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；pH 6.50
Resolution 1.90 Å R-free 0.229
1O1K Deoxy hemoglobin (A,C:V1M; B,D:V1M,V67W) Deposited 2002-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：V1M Mutation：V1M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；pH 6.50
Resolution 2.00 Å R-free 0.249
1O1L Deoxy hemoglobin (A-GLY-C:V1M,L29W,H58Q; B,D:V1M) Deposited 2002-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–141（141 aa）
Mutation：V1M, L29W, H58Q HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；pH 6.50
Resolution 1.80 Å R-free 0.254
1O1M Deoxy hemoglobin (A-GLYGLYGLY-C:V1M,L29F,H58Q B,D:V1M,V67W) Deposited 2002-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–141（141 aa）
Mutation：V1M, L29F, H58Q HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；pH 6.50
Resolution 1.85 Å R-free 0.250
1O1N Deoxy hemoglobin (A-GLYGLYGLY-C:V1M,L29W; B,D:V1M) Deposited 2002-11-17 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；pH 6.50
Resolution 1.80 Å R-free 0.242
1O1O Deoxy hemoglobin (A,C:V1M,V62L; B,D:V1M,V67L) Deposited 2002-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：V1M, V62L Mutation：V1M, V62L HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；pH 6.50
Resolution 1.80 Å R-free 0.222
1O1P Deoxy hemoglobin (A-GLY-C:V1M; B,D:V1M,C93A,N108K) Deposited 2002-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–141（141 aa）
Mutation：V1M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；pH 6.50
Resolution 1.80 Å R-free 0.245
1QI8 DEOXYGENATED STRUCTURE OF A DISTAL POCKET HEMOGLOBIN MUTANT Deposited 1999-06-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa） Fragment：ALPHA CHAIN
Chain C 1–141（141 aa） Fragment：ALPHA CHAIN
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；HIGH SALT (PERUTZ, 1968)., pH 6.5
Resolution 1.80 Å R-free 0.222
1QSH MAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME Deposited 1999-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 HEG PROTOPORPHYRIN IX CONTAINING MG × 2 X-RAY DIFFRACTION
X-ray crystallization conditions Batch Method；pH 6.5；298 K；Ammonium sulfate , pH 6.5, Batch Method, temperature 298K
Resolution 1.70 Å
1QSI MAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME Deposited 1999-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HEG PROTOPORPHYRIN IX CONTAINING MG × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH METHOD；pH 6.5；298 K；AMMONIUM SULFATE, pH 6.5, BATCH METHOD, temperature 298K
Resolution 1.70 Å
1QXD Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds Deposited 2003-09-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa） Fragment：alpha chain
Chain C 1–141（141 aa） Fragment：alpha chain
Not recorded SO4 SULFATE ION × 7 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FU2 FURFURAL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；ammonium phosphate and sulfate, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 2.25 Å R-free 0.274
1QXD Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds Deposited 2003-09-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–141（141 aa） Fragment：alpha chain
Chain C 1–141（141 aa） Fragment：alpha chain
Not recorded SO4 SULFATE ION × 14 HEM PROTOPORPHYRIN IX CONTAINING FE × 8 FU2 FURFURAL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；ammonium phosphate and sulfate, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 2.25 Å R-free 0.274
1QXE Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds Deposited 2003-09-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa） Fragment：alpha chain
Chain C 1–141（141 aa） Fragment：alpha chain
Not recorded SO4 SULFATE ION × 7 OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FUX 5-HYDROXYMETHYL-FURFURAL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；ammonium phosphate and sulfate, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 1.85 Å R-free 0.223
1QXE Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds Deposited 2003-09-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–141（141 aa） Fragment：alpha chain
Chain C 1–141（141 aa） Fragment：alpha chain
Not recorded SO4 SULFATE ION × 14 OXY OXYGEN MOLECULE × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 8 FUX 5-HYDROXYMETHYL-FURFURAL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；ammonium phosphate and sulfate, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 1.85 Å R-free 0.223
1QXE Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds Deposited 2003-09-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–141（141 aa） Fragment：alpha chain
Chain C 1–141（141 aa） Fragment：alpha chain
Not recorded SO4 SULFATE ION × 14 OXY OXYGEN MOLECULE × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 8 FUX 5-HYDROXYMETHYL-FURFURAL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；ammonium phosphate and sulfate, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 1.85 Å R-free 0.223
1R1X Crystal structure of oxy-human hemoglobin Bassett at 2.15 angstrom Deposited 2003-09-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Mutation：D94A CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；potassium/Sodium phosphate, toluene, hemoglobin, pH 6.7, LIQUID DIFFUSION, temperature 298K
Resolution 2.15 Å R-free 0.288
1R1Y Crystal structure of deoxy-human hemoglobin Bassett at 1.8 angstrom Deposited 2003-09-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：D94A Mutation：D94A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；Ammonium phosphate/sulfate, iron citrate, sodium dithionite, deoxyhemoglobin, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 1.80 Å R-free 0.236
1RPS Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin. Hemoglobin exposed to NO under anerobic conditions Deposited 2003-12-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NO NITRIC OXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10 mg/mL human hemoglobin, 10 mM potassium phosphate, 100 mM potassium chloride, 10-12% PEG 6000, 3 mM sodium dithionite (under anaerobic conditions), BATCH METHOD, temperature 298K, pH 7
Resolution 2.11 Å R-free 0.232
1RQ3 Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Deoxyhemoglobin, Deoxyhemoglobin Deposited 2003-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；pH 7.0
Resolution 1.91 Å R-free 0.198
1RQ4 Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin, HEMOGLOBIN EXPOSED TO NO UNDER AEROBIC CONDITIONS Deposited 2003-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NO NITRIC OXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；pH 7.0
Resolution 2.11 Å R-free 0.241
1RQA Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin. Beta W73E hemoglobin exposed to NO under anaerobic conditions Deposited 2003-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NO NITRIC OXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10 mg/mL human hemoglobin, 10 mM potassium phosphate, 100 mM potassium chloride, 10-12% PEG 6000, 3mM sodium dithionite (under anaerobic conditions), pH 7.0, BATCH METHOD, temperature 298K
Resolution 2.11 Å R-free 0.231
1RVW R STATE HUMAN HEMOGLOBIN [ALPHA V96W], CARBONMONOXY Deposited 1997-03-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Mutation：CHAIN A, V96W PO4 PHOSPHATE ION × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å
1SDK CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A Deposited 1996-02-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 TMM 1,3,5-BENZENETRICARBOXYLIC ACID × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1SDK CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A Deposited 1996-02-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 8 CMO CARBON MONOXIDE × 8 TMM 1,3,5-BENZENETRICARBOXYLIC ACID × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1SDL CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A Deposited 1996-02-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 TMM 1,3,5-BENZENETRICARBOXYLIC ACID × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1SDL CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A Deposited 1996-02-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 8 CMO CARBON MONOXIDE × 8 TMM 1,3,5-BENZENETRICARBOXYLIC ACID × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1SHR Crystal structure of ferrocyanide bound human hemoglobin A2 at 1.88A resolution Deposited 2004-02-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded CYN CYANIDE ION × 10 FE FE (III) ION × 3 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；PEG, glycerol, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 1.88 Å R-free 0.195
1SI4 Crystal structure of Human hemoglobin A2 (in R2 state) at 2.2 A resolution Deposited 2004-02-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded CYN CYANIDE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；PEG, Glycerol, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.20 Å R-free 0.258
1THB REFINEMENT OF A PARTIALLY OXYGENATED T STATE HAEMOGLOBIN AT 1.5 ANGSTROMS RESOLUTION Deposited 1990-01-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 IHP INOSITOL HEXAKISPHOSPHATE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
1UIW Crystal Structures of Unliganded and Half-Liganded Human Hemoglobin Derivatives Cross-Linked between Lys 82beta1 and Lys 82beta2 Deposited 2003-07-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.6；293 K；PEG6000, pH 6.60, SMALL TUBES, temperature 293K
Resolution 1.50 Å R-free 0.205
1UIW Crystal Structures of Unliganded and Half-Liganded Human Hemoglobin Derivatives Cross-Linked between Lys 82beta1 and Lys 82beta2 Deposited 2003-07-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 1–141（141 aa）
Chain G 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.6；293 K；PEG6000, pH 6.60, SMALL TUBES, temperature 293K
Resolution 1.50 Å R-free 0.205
1VWT T STATE HUMAN HEMOGLOBIN [ALPHA V96W], ALPHA AQUOMET, BETA DEOXY Deposited 1997-03-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：CHAIN A, C, V96W Mutation：CHAIN A, C, V96W HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å
1XXT The T-to-T High Transitions in Human Hemoglobin: wild-type deoxy Hb A (low salt, one test set) Deposited 2004-11-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml hemoglobin, pH 7.0, BATCH, temperature 298K
Resolution 1.91 Å R-free 0.239
1XY0 T-to-THigh Transitions in Human Hemoglobin: alphaK40G deoxy low-salt Deposited 2004-11-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：K40G, V1M Mutation：K40G, V1M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.99 Å R-free 0.260
1XZ5 T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaL91A deoxy low-salt Deposited 2004-11-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：V1M, L91A Mutation：V1M, L91A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM ammonium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.11 Å R-free 0.248
1XZ7 T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaR92A deoxy low-salt Deposited 2004-11-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：V1M, R92A Mutation：V1M, R92A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.90 Å R-free 0.203
1XZU T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaD94G deoxy low-salt Deposited 2004-11-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：V1M, D94G Mutation：V1M, D94G HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM ammonium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature , temperature 298K
Resolution 2.16 Å R-free 0.260
1XZV T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaP95A deoxy low-salt Deposited 2004-11-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：V1M, P95A Mutation：V1M, P95A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.11 Å R-free 0.246
1Y01 Crystal structure of AHSP bound to Fe(II) alpha-hemoglobin Deposited 2004-11-14 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 OXY OXYGEN MOLECULE × 1 CHK 6-[(CYCLOHEXYLACETYL)(2-HYDROXYETHYL)AMINO]-6-DEOXY-D-XYLO-HEXITOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；MES, PEG2000, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.80 Å R-free 0.292
1Y09 T-to-T(High) Quaternary Transitions in Human Hemoglobin: alphaN97A deoxy low-salt Deposited 2004-11-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：V1M, N97A Mutation：V1M, N97A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.25 Å R-free 0.206
1Y0A T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaY140A deoxy low-salt Deposited 2004-11-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：V1M, Y140A Mutation：V1M, Y140A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.22 Å R-free 0.237
1Y0C T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaY140F deoxy low-salt Deposited 2004-11-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：V1M, Y140F Mutation：V1M, Y140F HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.30 Å R-free 0.256
1Y0D T-to-THigh Quaternary Transitions in Human Hemoglobin: desArg141alpha deoxy low-salt Deposited 2004-11-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–140（140 aa） Fragment：Residues 1-140
Chain C 1–140（140 aa） Fragment：Residues 1-140
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.10 Å R-free 0.242
1Y0T T-to-T(High) Quaternary Transitions in Human Hemoglobin: betaV1M deoxy low-salt (1 test set) Deposited 2004-11-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.14 Å R-free 0.238
1Y0W T-to-THigh quaternary Transitions in Human Hemoglobin: betaV1M deoxy low-salt (10 test sets) Deposited 2004-11-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.14 Å R-free 0.192
1Y22 T-To-T(High) quaternary transitions in human hemoglobin: betaV33A deoxy low-salt (1 test set) Deposited 2004-11-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM POTASSIUM PHOSPHATE, 100 mM POTASSIUM CHLORIDE, 3 mM SODIUM DITHIONITE, 10 mg/ml Hb, pH 7.00, temperature 298K
Resolution 2.16 Å R-free 0.248
1Y2Z T-To-T(High) quaternary transitions in human hemoglobin: betaV34G deoxy low-salt (1 test set) Deposited 2004-11-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298.0K
Resolution 2.07 Å R-free 0.240
1Y31 T-To-T(High) quaternary transitions in human hemoglobin: betaY35A deoxy low-salt (1 test set) Deposited 2004-11-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298.0K
Resolution 2.13 Å R-free 0.251
1Y35 T-To-T(High) quaternary transitions in human hemoglobin: betaY35F deoxy low-salt (1 test set) Deposited 2004-11-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.12 Å R-free 0.244
1Y45 T-To-T(high) quaternary transitions in human hemoglobin: betaP36A deoxy low-salt (10 test sets) Deposited 2004-11-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.00 Å R-free 0.209
1Y46 T-To-T(High) quaternary transitions in human hemoglobin: betaW37Y deoxy low-salt (10 test sets) Deposited 2004-11-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.22 Å R-free 0.243
1Y4B T-To-T(High) quaternary transitions in human hemoglobin: betaW37H deoxy low-salt (10 test sets) Deposited 2004-11-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.10 Å R-free 0.238
1Y4F T-To-T(High) quaternary transitions in human hemoglobin: betaW37A deoxy low-salt (10 test sets) Deposited 2004-11-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.00 Å R-free 0.216
1Y4G T-To-T(High) quaternary transitions in human hemoglobin: betaW37G deoxy low-salt (10 test sets) Deposited 2004-11-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.91 Å R-free 0.235
1Y4P T-To-T(high) quaternary transitions in human hemoglobin: betaW37E deoxy low-salt (10 test sets) Deposited 2004-12-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.98 Å R-free 0.231
1Y4Q T-To-T(High) quaternary transitions in human hemoglobin: betaF42A deoxy low-salt (1 test set) Deposited 2004-12-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.11 Å R-free 0.245
1Y4R T-To-T(High) quaternary transitions in human hemoglobin: betaF45A deoxy low-salt (1 test set) Deposited 2004-12-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.22 Å R-free 0.246
1Y4V T-To-T(High) quaternary transitions in human hemoglobin: betaC93A deoxy low-salt (1 test set) Deposited 2004-12-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.84 Å R-free 0.230
1Y5F T-To-T(High) quaternary transitions in human hemoglobin: betaL96A deoxy low-salt (1 test set) Deposited 2004-12-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.14 Å R-free 0.243
1Y5J T-To-T(High) quaternary transitions in human hemoglobin: betaH97A deoxy low-salt (1 test set) Deposited 2004-12-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.03 Å R-free 0.245
1Y5K T-To-T(High) quaternary transitions in human hemoglobin: betaD99A deoxy low-salt (10 test sets) Deposited 2004-12-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.20 Å R-free 0.227
1Y7C T-To-T(High) quaternary transitions in human hemoglobin: betaP100A deoxy low-salt (1 test set) Deposited 2004-12-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.10 Å R-free 0.284
1Y7D T-To-T(High) quaternary transitions in human hemoglobin: betaP100G deoxy low-salt (1 test set) Deposited 2004-12-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.90 Å R-free 0.252
1Y7G T-To-T(high) quaternary transitions in human hemoglobin: betaN102A deoxy low-salt (1 test set) Deposited 2004-12-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.10 Å R-free 0.264
1Y7Z T-To-T(High) quaternary transitions in human hemoglobin: betaN108A deoxy low-salt (1 test set) Deposited 2004-12-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.98 Å R-free 0.233
1Y83 T-To-T(High) quaternary transitions in human hemoglobin: betaY145G deoxy low-salt (1 test set) Deposited 2004-12-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.90 Å R-free 0.248
1Y85 T-To-T(High) quaternary transitions in human hemoglobin: desHIS146beta deoxy low-salt Deposited 2004-12-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.00, batch, temperature 298.0K
Resolution 2.13 Å R-free 0.237
1Y8W T-To-T(High) quaternary transitions in human hemoglobin: alphaR92A oxy (2mM IHP, 20% PEG) (10 test sets) Deposited 2004-12-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：V1M, R92A Mutation：V1M, R92A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 2.90 Å R-free 0.267
1YDZ T-To-T(High) quaternary transitions in human hemoglobin: alphaY140F oxy (2MM IHP, 20% PEG) (1 test set) Deposited 2004-12-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Mutation：V1M, Y140F Mutation：V1M, Y140F HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 3.30 Å R-free 0.307
1YE0 T-To-T(High) quaternary transitions in human hemoglobin: betaV33A oxy (2MM IHP, 20% PEG) (1 test set) Deposited 2004-12-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 2.50 Å R-free 0.264
1YE1 T-To-T(High) quaternary transitions in human hemoglobin: betaY35A oxy (2MM IHP, 20% PEG) (1 test set) Deposited 2004-12-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 4.50 Å R-free 0.343
1YE2 T-To-T(High) quaternary transitions in human hemoglobin: betaY35F oxy (2MM IHP, 20% PEG) (1 test set) Deposited 2004-12-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 1.80 Å R-free 0.212
1YEN T-To-T(High) quaternary transitions in human hemoglobin: betaP36A oxy (2MM IHP, 20% PEG) (10 test sets) Deposited 2004-12-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 2.80 Å R-free 0.267
1YEO T-To-T(High) quaternary transitions in human hemoglobin: betaW37A OXY (10 test sets) Deposited 2004-12-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 13% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE. THE CRYSTAL WAS THEN EXPOSED TO AIR AT 298K AND DATA WAS COLLECTED AT 298K.
Resolution 2.22 Å R-free 0.228
1YEQ T-To-T(High) quaternary transitions in human hemoglobin: betaW37Y OXY (10 test sets) Deposited 2004-12-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 13% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE. THE CRYSTAL WAS THEN EXPOSED TO AIR AT 298K AND DATA WAS COLLECTED AT 298K.
Resolution 2.75 Å R-free 0.274
1YEU T-To-T(High) quaternary transitions in human hemoglobin: betaW37G OXY (10 test sets) Deposited 2004-12-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 13% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE. THE CRYSTAL WAS THEN EXPOSED TO AIR AT 298K AND DATA WAS COLLECTED AT 298K.
Resolution 2.12 Å R-free 0.254
1YEV T-To-T(High) quaternary transitions in human hemoglobin: betaW37E OXY (10 test sets) Deposited 2004-12-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 13% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE. THE CRYSTAL WAS THEN EXPOSED TO AIR AT 298K AND DATA WAS COLLECTED AT 298K.
Resolution 2.11 Å R-free 0.242
1YFF STRUCTURE OF HUMAN CARBONMONOXYHEMOGLOBIN C (BETA E6K): TWO QUATERNARY STATES (R2 and R3) IN ONE CRYSTAL Deposited 2004-12-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；PEG 4000, SODIUM PHOSPHATE, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.40 Å R-free 0.250
1YFF STRUCTURE OF HUMAN CARBONMONOXYHEMOGLOBIN C (BETA E6K): TWO QUATERNARY STATES (R2 and R3) IN ONE CRYSTAL Deposited 2004-12-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 1–141（141 aa）
Chain G 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；PEG 4000, SODIUM PHOSPHATE, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.40 Å R-free 0.250
1YG5 T-To-T(High) quaternary transitions in human hemoglobin: betaW37H OXY (2MM IHP, 20% PEG) (10 test sets) Deposited 2005-01-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 2.70 Å R-free 0.273
1YGD T-To-T(High) quaternary transitions in human hemoglobin: betaW37E alpha zinc beta oxy (10 TEST SETS) Deposited 2005-01-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded ZNH PROTOPORPHYRIN IX CONTAINING ZN × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 13% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE. THE CRYSTAL WAS THEN EXPOSED TO AIR AT 298K AND DATA WAS COLLECTED AT 298K.
Resolution 2.73 Å R-free 0.266
1YGF T-to-T(high) quaternary transitions in human hemoglobin: betaH97A oxy (2MM IHP, 20% PEG) (1 test set) Deposited 2005-01-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 2.70 Å R-free 0.270
1YH9 T-to-T(High) quaternary transitions in human hemoglobin: HbA OXY (2MM IHP, 20% PEG) (10 test sets) Deposited 2005-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 2.20 Å R-free 0.236
1YHE T-To-T(High) quaternary transitions in human hemoglobin: HbA OXY (5.0MM IHP, 20% PEG) (10 test sets) Deposited 2005-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 5.0 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 2.10 Å R-free 0.208
1YHR T-To-T(High) quaternary transitions in human hemoglobin: HbA OXY (10.0MM IHP, 20% PEG) (10 test sets) Deposited 2005-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, 1 ATM N2, pH 7.0, batch, temperature 298.0K
Resolution 2.60 Å R-free 0.270
1YIE T-to-thigh quaternary transitions in human hemoglobin: betaW37A oxy (2.2MM IHP, 13% PEG) (1 test set) Deposited 2005-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, 1 ATM N2, pH 7.00, batch, temperature 298.0K
Resolution 2.40 Å R-free 0.273
1YIH T-to-T(High) quaternary transitions in human hemoglobin: betaP100A oxy (2.2MM IHP, 20% PEG) (1 test set) Deposited 2005-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, 1 ATM N2, pH 7.0, batch, temperature 298.0K
Resolution 2.00 Å R-free 0.247
1YVQ The low salt (PEG) crystal structure of CO Hemoglobin E (betaE26K) approaching physiological pH (pH 7.5) Deposited 2005-02-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；290 K；0.1M HEPES, pH 7.5; 10% isopropanol, 20% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 290K
Resolution 1.80 Å R-free 0.230
1YVT The high salt (phosphate) crystal structure of CO Hemoglobin E (Glu26Lys) at physiological pH (pH 7.35) Deposited 2005-02-16 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.35；289 K；1.65M potassium phosphate, 0.1M HEPES, ph 7.35, Batch Method, temperature 289K
Resolution 1.80 Å R-free 0.236
1YZI A novel quaternary structure of human carbonmonoxy hemoglobin Deposited 2005-02-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 6 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 7.1；298 K；sodium/potassium phosphate, toluene, pH 7.1, SMALL TUBES, temperature 298K
Resolution 2.07 Å R-free 0.257
1Z8U Crystal structure of oxidized alpha hemoglobin bound to AHSP Deposited 2005-03-31 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；MES, PEG-2000 monomethyl ether, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.40 Å R-free 0.252
1Z8U Crystal structure of oxidized alpha hemoglobin bound to AHSP Deposited 2005-03-31 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；MES, PEG-2000 monomethyl ether, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.40 Å R-free 0.252
1Z8U Crystal structure of oxidized alpha hemoglobin bound to AHSP Deposited 2005-03-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–141（141 aa）
Chain D 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；MES, PEG-2000 monomethyl ether, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.40 Å R-free 0.252
28OD Crystal structure of C35 bound to Hem Deposited 2026-02-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 4 A1ITR 4-[2-[[5-(1H-indol-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanoylamino]benzoic acid × 2 DMS DIMETHYL SULFOXIDE × 10 CMO CARBON MONOXIDE × 4 ACT ACETATE ION × 3 SO4 SULFATE ION × 20 PGE TRIETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；3.0 M Ammonium sulfate; 1% (wv) MPD
Resolution 1.73 Å R-free 0.200
2D5Z Crystal structure of T-state human hemoglobin complexed with three L35 molecules Deposited 2005-11-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 L35 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID × 3 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 5.8；293 K；18% PEG 6000, 100mM Na-Cacodylate, 0.1mM L35, pH 5.8, BATCH, temperature 293K
Resolution 1.45 Å R-free 0.215
2D60 Crystal structure of deoxy human hemoglobin complexed with two L35 molecules Deposited 2005-11-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 L35 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.5；293 K；2.5M Ammonium sulfate, Ammonium phosphate, 0.1mM L35, pH 6.5, BATCH, temperature 293K
Resolution 1.70 Å R-free 0.240
2DN1 1.25A resolution crystal structure of human hemoglobin in the oxy form Deposited 2006-04-25 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 MBN TOLUENE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 6.7；277 K；sodium/potassium phosphate, glycerol, pH 6.7, Batch, temperature 277K
Resolution 1.25 Å
2DN2 1.25A resolution crystal structure of human hemoglobin in the deoxy form Deposited 2006-04-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 6.5；293 K；Ammonium sulfate, Ammonium phosphate, pH 6.5, Batch, temperature 293K
Resolution 1.25 Å
2DN3 1.25A resolution crystal structure of human hemoglobin in the carbonmonoxy form Deposited 2006-04-25 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.7；293 K；sodium/potassium phosphate, glycerol, pH 6.7, BATCH, temperature 293K
Resolution 1.25 Å
2DXM Neutron Structure Analysis of Deoxy Human Hemoglobin Deposited 2006-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NEUTRON DIFFRACTION
X-ray crystallization conditions MICRODIALYSIS；D2O, MICRODIALYSIS
Resolution 2.10 Å R-free 0.260
2H35 Solution structure of Human normal adult hemoglobin Deposited 2006-05-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SOLUTION NMR
NMR measurement conditions pH 7；303 K；Ionic strength (raw mmCIF value) 100 mM；Pressure 1
NMR sample composition alpha_subunit 1.0mM, Na phosphate 0.1M, 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR sample composition beta_subunit 1.0mM, Na phosphate 0.1M, 90% H2O, 10% D2O | 90% H2O/10% D2O
Resolution not provided
2HBC HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES Deposited 1994-08-31 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ENC ETHYL ISOCYANIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å
2HBD HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES Deposited 1994-08-31 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MNC METHYL ISOCYANIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å
2HBE HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES Deposited 1994-08-31 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NBN N-BUTYL ISOCYANIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å
2HBF HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES Deposited 1994-08-31 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NPN N-PROPYL ISOCYANIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å
2HBS THE HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S Deposited 1997-05-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 4；HBS WAS SUSPENDED IN 30 MM PHOSPHATE BUFFER, PH 7.0, DEOXYGENATED AND CONCENTRATED TO 120 MG/ML. PROTEIN WAS CRYSTALLIZED IN AN ANAEROBIC CHAMBER IN TUBE CONTAINING 10 UL PROTEIN SOLUTION, 5 UL CITRATE BUFFER (PH 4.0), AND 4UL OF 33% PEG 8K, crystallized in anaerobic chamber
Resolution 2.05 Å R-free 0.215
2HBS THE HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S Deposited 1997-05-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 1–141（141 aa）
Chain G 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 4；HBS WAS SUSPENDED IN 30 MM PHOSPHATE BUFFER, PH 7.0, DEOXYGENATED AND CONCENTRATED TO 120 MG/ML. PROTEIN WAS CRYSTALLIZED IN AN ANAEROBIC CHAMBER IN TUBE CONTAINING 10 UL PROTEIN SOLUTION, 5 UL CITRATE BUFFER (PH 4.0), AND 4UL OF 33% PEG 8K, crystallized in anaerobic chamber
Resolution 2.05 Å R-free 0.215
2HCO THE STRUCTURE OF HUMAN CARBONMONOXY HAEMOGLOBIN AT 2.7 ANGSTROMS RESOLUTION Deposited 1979-08-07 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å
2HHE OXYGEN AFFINITY MODULATION BY THE N-TERMINI OF THE BETA CHAINS IN HUMAN AND BOVINE HEMOGLOBIN Deposited 1994-09-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å
2M6Z Refined solution structure of Human Adult Hemoglobin in the Carbonmonoxy Form Deposited 2013-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SOLUTION NMR
NMR measurement conditions pH 7；308 K
NMR sample composition 1.2 mM [U-13C; U-15N] HbCO A-1, 1.0 mM [U-13C; U-15N] HbCO A-2, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
2W6V Structure of Human deoxy Hemoglobin A in complex with Xenon Deposited 2008-12-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa） Fragment：CHAIN ALPHA, RESIDUES 2-142
Chain C 2–142（141 aa） Fragment：CHAIN ALPHA, RESIDUES 2-142
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 3 SO4 SULFATE ION × 5 XE XENON × 10 PO4 PHOSPHATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；3.2M (NH4)2SO4, 0.1M (NH4)H2PO4, 0.3M (NH4)2HPO4, PH 6.5, 0.2% DITHIONITE.
Resolution 1.80 Å R-free 0.216
2W72 DEOXYGENATED STRUCTURE OF A DISTAL SITE HEMOGLOBIN MUTANT PLUS XE Deposited 2008-12-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa） Fragment：CHAIN ALPHA, RESIDUES 2-142
Chain C 2–142（141 aa） Fragment：CHAIN ALPHA, RESIDUES 2-142
Mutation：YES Mutation：YES HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 8 XE XENON × 15 K POTASSIUM ION × 3 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；3.2M AMMONIUM SULPHATE 0.1M AMMONIUM PHOSPHATE 0.3M K PHOSPHATE PH 6.7
Resolution 1.07 Å R-free 0.153
2YRS Human hemoglobin D Los Angeles: crystal structure Deposited 2007-04-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.6；293 K；pH 7.6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.30 Å R-free 0.252
2YRS Human hemoglobin D Los Angeles: crystal structure Deposited 2007-04-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain I 2–142（141 aa）
Chain M 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.6；293 K；pH 7.6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.30 Å R-free 0.252
3B75 Crystal Structure of Glycated Human Haemoglobin Deposited 2007-10-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded FRU beta-D-fructofuranose × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 GLC alpha-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.7；277 K；PEG 4000, pH 6.7, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.30 Å R-free 0.331
3B75 Crystal Structure of Glycated Human Haemoglobin Deposited 2007-10-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded FRU beta-D-fructofuranose × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.7；277 K；PEG 4000, pH 6.7, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.30 Å R-free 0.331
3B75 Crystal Structure of Glycated Human Haemoglobin Deposited 2007-10-30 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain S 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 GLC alpha-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.7；277 K；PEG 4000, pH 6.7, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.30 Å R-free 0.331
3D17 A triply ligated crystal structure of relaxed state human hemoglobin Deposited 2008-05-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 1 CMO CARBON MONOXIDE × 3 PO4 PHOSPHATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.4；298 K；NaPhosph, KPhosph, Toluene, pH 6.4, liquid diffusion, temperature 298K
Resolution 2.80 Å R-free 0.297
3D7O Human hemoglobin, nitrogen dioxide anion modified Deposited 2008-05-21 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded NO2 NITRITE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；295 K；Sodium phosphate, Potassium phosphate, Toluene, Hemoglobin, pH 6.8, LIQUID DIFFUSION, temperature 295K
Resolution 1.80 Å R-free 0.237
3DUT The high salt (phosphate) crystal structure of deoxy hemoglobin E (GLU26LYS) at physiological pH (pH 7.35) Deposited 2008-07-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.35；294 K；1.65 M potassium phosphate, 0.05 M Bis-Tris, pH 7.35, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.55 Å R-free 0.277
3HXN The structure of human carbonmonoxyhemoglobin complex to IHP at 2.0 angstrons resolution. Deposited 2009-06-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 IHP INOSITOL HEXAKISPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；295 K；CARBONMONOXYHEMOGLOBIN:IHP 1:1, CRYSTALLIZED IN 27% PEG 3350 BUBBLED IN CO- , pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.00 Å R-free 0.283
3IA3 A cis-proline in alpha-hemoglobin stabilizing Protein directs the structural reorganization of alpha-hemoglobin Deposited 2009-07-13 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M MES, pH 6.5, 4% acetonitrile and 14.5% (w/v) PEG3000, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 3.20 Å R-free 0.293
3IA3 A cis-proline in alpha-hemoglobin stabilizing Protein directs the structural reorganization of alpha-hemoglobin Deposited 2009-07-13 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M MES, pH 6.5, 4% acetonitrile and 14.5% (w/v) PEG3000, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 3.20 Å R-free 0.293
3IC0 Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-298 Deposited 2009-07-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 B77 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；3.2 - 3.6 M Sulfate/phosphate precipitant, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 1.80 Å R-free 0.230
3IC2 Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-266 Deposited 2009-07-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 B78 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；3.2 - 3.6 M Sulfate/phosphate precipitant, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 2.40 Å R-free 0.246
3KMF Room Temperature Time-of-Flight Neutron Diffraction Study of Deoxy Human Normal Adult Hemoglobin Deposited 2009-11-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain E 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NEUTRON DIFFRACTION
X-ray crystallization conditions batch；pH 6.7；293 K；D2O, BATCH, ammonium sulfate, pH 6.7, batch, temperature 293K
Resolution 2.00 Å R-free 0.300
3NL7 Human Hemoglobin A mutant beta H63W carbonmonoxy-form Deposited 2010-06-21 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.7；293 K；Protein Solution (20mg/ml protein in 0.01 M phosphate pH 7.0) mixed with mother liquor (3.4 M Na/K phosphate, pH6.7) for final concentrations of 2.3 M Na/K phosphate, SMALL TUBES, temperature 293K
Resolution 1.80 Å R-free 0.233
3NMM Human Hemoglobin A mutant alpha H58W deoxy-form Deposited 2010-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Mutation：H59W Mutation：H59W HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions Batch Method；pH 6.5；293 K；20 ul Protein Solution (60mg/ml protein in 0.01 M ammonium phosphate pH 7.0) mixed with 100 ul mother liquor (0.5 ml 2M monobasic ammonium phosphate + 1.5 ml 2 M dibasic ammonium phosphate + 8 ml 4 M ammonium sulfate) for final concentrations of 2.4-2.6 M Ammonium phosphate/sulfate, Batch Method, temperature 293K
Resolution 1.60 Å R-free 0.198
3ODQ Structure of a Crystal Form of Human Methemoglobin Indicative of Fiber Formation Deposited 2010-08-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；295 K；15-30% PEG, pH 4.5-5.5, 0.2 M salt of several varieties, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.325
3ONZ Human tetrameric hemoglobin: proximal nitrite ligand at beta Deposited 2010-08-30 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa） Fragment：Hemoglobin Chain A
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NO2 NITRITE ION × 4 MBN TOLUENE × 8 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 7.1；295 K；sodium phospahte, potassium phosphate, toluene, nitrite, hemoglobin, pH 7.1, LIQUID DIFFUSION, temperature 295K
Resolution 2.09 Å R-free 0.280
3OO4 R-state human hemoglobin: nitriheme modified at alpha Deposited 2010-08-30 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded NTE [3,3'-{7-ethenyl-3,8,13,17-tetramethyl-12-[(E)-2-nitroethenyl]porphyrin-2,18-diyl-kappa~4~N~21~,N~22~,N~23~,N~24~}dipro panoato(2-)]iron × 2 NO2 NITRITE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；295 K；sodium phosphate, potassium phosphate, nitrite, toluene, hemoglobin, pH 6.8, LIQUID DIFFUSION, temperature 295K
Resolution 1.90 Å R-free 0.263
3OO5 R-state human hemoglobin: nitriheme modified Deposited 2010-08-30 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded NTE [3,3'-{7-ethenyl-3,8,13,17-tetramethyl-12-[(E)-2-nitroethenyl]porphyrin-2,18-diyl-kappa~4~N~21~,N~22~,N~23~,N~24~}dipro panoato(2-)]iron × 4 NO2 NITRITE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；295 K；sodium phosphate, potassium phosphate, nitrite, toluene, human hemoglobin, LIQUID DIFFUSION, temperature 295K
Resolution 2.10 Å R-free 0.287
3OVU Crystal Structure of Human Alpha-Haemoglobin Complexed with AHSP and the First NEAT Domain of IsdH from Staphylococcus aureus Deposited 2010-09-17 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.2M sodium acetate, 20%(w/v) PEG 3350, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.83 Å R-free 0.280
3P5Q Ferric R-state human aquomethemoglobin Deposited 2010-10-10 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 6 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；295 K；sodium phosphate, potassium phosphate, toluene, hemoglobin, pH 6.8, LIQUID DIFFUSION, temperature 295K
Resolution 2.00 Å R-free 0.267
3QJB Human Hemoglobin A Mutant Alpha H58L Carbonmonoxy-Form Deposited 2011-01-28 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Mutation：H58L HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.7；293 K；2.3 M Na/K phosphate, pH 6.7, SMALL TUBES, temperature 293K
Resolution 1.80 Å R-free 0.205
3QJC Human Hemoglobin A Mutant Beta H63L Carbonmonoxy-Form Deposited 2011-01-28 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.7；293 K；2.3 M Na/K phosphate, pH 6.7, SMALL TUBES, temperature 293K
Resolution 2.00 Å R-free 0.250
3QJD Human Hemoglobin A Mutant Alpha H58L Deoxy-Form Deposited 2011-01-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Mutation：H58L Mutation：H58L HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.5；293 K；2.4-2.6 M ammonium phosphate/sulfate, pH 6.5, SMALL TUBES, temperature 293K
Resolution 1.56 Å R-free 0.191
3QJE Human Hemoglobin A Mutant Beta H63L Deoxy-Form Deposited 2011-01-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.5；293 K；2.4-2.6 M ammonium phosphate/sulfate, pH 6.5, SMALL TUBES, temperature 293K
Resolution 1.80 Å R-free 0.243
3R5I Crystal structure of liganded Hemoglobin complexed with a potent Antisickling agent, INN-312 Deposited 2011-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 3R5 5-methoxy-2-(pyridin-3-ylmethoxy)benzaldehyde × 3 SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.4；298 K；3.2 M Na+/K+ phosphate, pH 6.4, LIQUID DIFFUSION, temperature 298K
Resolution 2.20 Å R-free 0.268
3S48 Human Alpha-Haemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus Deposited 2011-05-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.2M sodium sulphate, 0.1M Bis Tris propane, 16%(w/v) PEG 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.05 Å R-free 0.268
3S48 Human Alpha-Haemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus Deposited 2011-05-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.2M sodium sulphate, 0.1M Bis Tris propane, 16%(w/v) PEG 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.05 Å R-free 0.268
3S65 Structures and oxygen affinities of crystalline human hemoglobin C (beta6 Lys) in the R2 quaternary structures Deposited 2011-05-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.6；293 K；11% (w/v) polyethylene glycol 3350, 50mM HEPES buffer, 10% (v/v) glycerol, pH 7.6, Batch, temperature 293K
Resolution 1.80 Å R-free 0.305
3S66 Structures and oxygen affinities of crystalline human hemoglobin C (beta6 Lys) in the R quaternary structures Deposited 2011-05-25 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；293 K；1.65M phosphate buffer (0.528M NaH2PO4, 1.122M K2HPO4, pH 7.2), 10% (v/v) glycerol, 0.1% (w/v) D,L-homocysteine, Batch, temperature 293K
Resolution 1.40 Å R-free 0.233
3SZK Crystal Structure of Human metHaemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus Deposited 2011-07-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain D 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.2M potassium thiocyanate, 0.1M Tris-bis propane, 20% PEG 3350 , pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.01 Å R-free 0.275
3SZK Crystal Structure of Human metHaemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus Deposited 2011-07-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.2M potassium thiocyanate, 0.1M Tris-bis propane, 20% PEG 3350 , pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.01 Å R-free 0.275
3WCP Deoxyhemoglobin SH-drug complex Deposited 2013-05-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 DG2 (2R)-2,3-diphosphoglyceric acid × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.6；298 K；0.2M sodium acetate trihydrate, 0.1M sodium cacodylate trihydrate, 30% PEG8000, pH 6.6, batch, temperature 298K
Resolution 1.94 Å R-free 0.263
3WHM Structure of Hemoglobin Complex with 18-crown-6 Deposited 2013-08-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain E 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 5 OXY OXYGEN MOLECULE × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；30% (w/v) PEG 3350, 0.2M Lithium sulfate, 0.1M Tris pH 8.0, 25mM 18-crown-6, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 1.85 Å R-free 0.253
4FC3 Crystal Structure of Human Methaemoglobin Complexed with the Second NEAT Domain of IsdH from Staphylococcus aureus Deposited 2012-05-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.2M Sodium formate, 0.1M bis-tris propane, 20% PEG3350, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.26 Å R-free 0.256
4HHB THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION Deposited 1984-03-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.74 Å
4IJ2 Human methemoglobin in complex with the second and third NEAT domains of IsdH from Staphylococcus aureus Deposited 2012-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.6；294 K；0.2M diammonium citrate, 13%(w/v) PEG3350, 0.7% 1-butanol, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 4.24 Å R-free 0.310
4L7Y Deoxygenated Hb in complex with the allosteric effectors, IRL2500 and 2,3-DPG Deposited 2013-06-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded MH0 Mesoheme × 4 IRL (2R)-2-({(2S)-3-(biphenyl-4-yl)-2-[(3,5-dimethylbenzoyl)(methyl)amino]propanoyl}amino)-3-(1H-indol-3-yl)propanoic acid (non-preferred name) × 1 DG2 (2R)-2,3-diphosphoglyceric acid × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.6；297 K；0.2M sodium acetate trihydrate, 0.1M sodium cacodylate trihydrate,30% PEG8000, pH 6.6, LIQUID DIFFUSION, temperature 297K
Resolution 1.80 Å R-free 0.228
4M4A Human Hemoglobin Nitromethane Modified Deposited 2013-08-06 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NSM NITROSOMETHANE × 4 GOL GLYCEROL × 6 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；295 K；sodium phosphate, potassium phosphate, toluene, pH 6.8, LIQUID DIFFUSION, temperature 295K
Resolution 2.05 Å R-free 0.280
4M4B Human Hemoglobin Nitroethane Modified Deposited 2013-08-06 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 2 NOE NITROSOETHANE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；295 K；sodium phosphate, potassium phosphate, toluene, pH 6.8, LIQUID DIFFUSION, temperature 295K
Resolution 2.00 Å R-free 0.270
4MQC Carbonmonoxy Structure of Hemoglobin Evans alphaV62Mbetawt Deposited 2013-09-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Mutation：V67M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；Protein crystallized from 2.2M Sodium/Potassium Phosphate, batch method, pH 6.7, LIQUID DIFFUSION, temperature 298K
Resolution 2.20 Å R-free 0.250
4MQG Structure of Carbonmonoxy Adult Hemoglobin Bristol-Alesha alphawtbetaV67M Deposited 2013-09-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Mutation：V67M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；Protein crystallized from 1.9M Sodium/Potassium Phosphate, Batch method, pH 7.0, LIQUID DIFFUSION, temperature 298K
Resolution 1.68 Å R-free 0.243
4MQH Structure of Aquomet Hemoglobin Evans alphaV62Mbetawt Deposited 2013-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–140（139 aa）
Mutation：V67M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；Protein crystallized from 2.2M Sodium/Potassium Phosphate, pH 6.7, Batch method, temperature 298K, LIQUID DIFFUSION
Resolution 2.50 Å R-free 0.250
4MQI Structure of Aquomet Hemoglobin Bristol-Alesha alphawtbetaV67M Deposited 2013-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–141（140 aa）
Mutation：V67M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；Protein crystallized from 2.2M Sodium/Potassium Phosphate, pH 6.7, Batch method, temperature 298K, LIQUID DIFFUSION
Resolution 1.92 Å R-free 0.239
4MQJ Structure of Wild-type Fetal Human Hemoglobin HbF Deposited 2013-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 7；298 K；Protein crystallized from 1.9M Sodium/Potassium Phosphate, pH 7.0, Batch method, temperature 298K, LIQUID DIFFUSION
Resolution 1.80 Å R-free 0.215
4MQJ Structure of Wild-type Fetal Human Hemoglobin HbF Deposited 2013-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 2–142（141 aa）
Chain E 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 2 OXY OXYGEN MOLECULE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 7；298 K；Protein crystallized from 1.9M Sodium/Potassium Phosphate, pH 7.0, Batch method, temperature 298K, LIQUID DIFFUSION
Resolution 1.80 Å R-free 0.215
4MQK Carbonmonoxy Structure of the Human Fetal Hemoglobin Mutant HbF Toms River alphawtgammaV67M Deposited 2013-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain E 2–142（141 aa）
Mutation：V67M Mutation：V67M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 3 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 7；298 K；1.9M Sodium/Potassium Phosphate, Batch method, pH 7, EVAPORATION, temperature 298K
Resolution 2.24 Å R-free 0.232
4MQK Carbonmonoxy Structure of the Human Fetal Hemoglobin Mutant HbF Toms River alphawtgammaV67M Deposited 2013-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 2–142（141 aa）
Chain G 2–142（141 aa）
Mutation：V67M Mutation：V67M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 3 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 7；298 K；1.9M Sodium/Potassium Phosphate, Batch method, pH 7, EVAPORATION, temperature 298K
Resolution 2.24 Å R-free 0.232
4N7N Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of full-liganded human haemoglobin with phosphate at 2.75 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa） Fragment：UNP residues 2-142
Chain C 2–142（141 aa） Fragment：UNP residues 2-142
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 6.8；298 K；18% PEG3350, 5% glycerol , pH 6.8, microbatch under paraffin oil, temperature 298K
Resolution 2.75 Å R-free 0.286
4N7N Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of full-liganded human haemoglobin with phosphate at 2.75 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa） Fragment：UNP residues 2-142
Chain G 2–142（141 aa） Fragment：UNP residues 2-142
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 6.8；298 K；18% PEG3350, 5% glycerol , pH 6.8, microbatch under paraffin oil, temperature 298K
Resolution 2.75 Å R-free 0.286
4N7N Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of full-liganded human haemoglobin with phosphate at 2.75 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain I 2–142（141 aa） Fragment：UNP residues 2-142
Chain K 2–142（141 aa） Fragment：UNP residues 2-142
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 6.8；298 K；18% PEG3350, 5% glycerol , pH 6.8, microbatch under paraffin oil, temperature 298K
Resolution 2.75 Å R-free 0.286
4N7O Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin with phosphate at 2.5 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa） Fragment：UNP residues 2-142
Chain C 2–142（141 aa） Fragment：UNP residues 2-142
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 6.8；298 K；CO-saturated 1.0% XL[alpha(Fe-Co)beta(Ni)][alpha(Ni)beta(Fe-Co)], 17% PEG3350, 10mM Potassium phosphate pH6.8 , microbatch under paraffin oil, temperature 298K
Resolution 2.50 Å R-free 0.292
4N7O Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin with phosphate at 2.5 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa） Fragment：UNP residues 2-142
Chain G 2–142（141 aa） Fragment：UNP residues 2-142
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 6.8；298 K；CO-saturated 1.0% XL[alpha(Fe-Co)beta(Ni)][alpha(Ni)beta(Fe-Co)], 17% PEG3350, 10mM Potassium phosphate pH6.8 , microbatch under paraffin oil, temperature 298K
Resolution 2.50 Å R-free 0.292
4N7O Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin with phosphate at 2.5 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain I 2–142（141 aa） Fragment：UNP residues 2-142
Chain K 2–142（141 aa） Fragment：UNP residues 2-142
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 6.8；298 K；CO-saturated 1.0% XL[alpha(Fe-Co)beta(Ni)][alpha(Ni)beta(Fe-Co)], 17% PEG3350, 10mM Potassium phosphate pH6.8 , microbatch under paraffin oil, temperature 298K
Resolution 2.50 Å R-free 0.292
4N7P Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin without phosphate at 2.8 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa） Fragment：UNP residues 2-142
Chain C 2–142（141 aa） Fragment：UNP residues 2-142
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 7.6；298 K；pH 7.6, microbatch under paraffin oil, temperature 298K
Resolution 2.81 Å R-free 0.287
4N7P Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin without phosphate at 2.8 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa） Fragment：UNP residues 2-142
Chain G 2–142（141 aa） Fragment：UNP residues 2-142
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 7.6；298 K；pH 7.6, microbatch under paraffin oil, temperature 298K
Resolution 2.81 Å R-free 0.287
4N7P Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin without phosphate at 2.8 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain I 2–142（141 aa） Fragment：UNP residues 2-142
Chain K 2–142（141 aa） Fragment：UNP residues 2-142
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 7.6；298 K；pH 7.6, microbatch under paraffin oil, temperature 298K
Resolution 2.81 Å R-free 0.287
4N8T Human hemoglobin nitric oxide adduct Deposited 2013-10-18 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 6 NO2 NITRITE ION × 2 NO NITRIC OXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；295 K；SOLDIUM PHOSPHATE, POTASSIUM PHOSPHATE, TOLUENE, HUMAN HEMOGLOBIN, pH 6.8, LIQUID DIFFUSION, temperature 295K
Resolution 1.90 Å R-free 0.252
4NI0 Quaternary R3 CO-liganded hemoglobin structure in complex with a thiol containing compound Deposited 2013-11-05 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 2P3 5-[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione × 8 MBN TOLUENE × 6 PO4 PHOSPHATE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；298 K；20-30mg/mL protein, 3.0-3.4 M Sodium/potassium phosphate, pH 6.8, LIQUID DIFFUSION, temperature 298K
Resolution 2.15 Å R-free 0.259
4NI1 Quaternary R CO-liganded hemoglobin structure in complex with a thiol containing compound Deposited 2013-11-05 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 2JX 5-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione × 8 MBN TOLUENE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.4；298 K；20-30mg/mL protein, 3.0-3.4 M sodium/potassium phosphate, pH 6.4, LIQUID DIFFUSION, temperature 298K
Resolution 1.90 Å R-free 0.259
4ROL Deoxyhemoglobin in complex with imidazolylacryloyl derivatives Deposited 2014-10-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 3U7 4-{2,3-dichloro-4-[3-(1H-imidazol-2-yl)propanoyl]phenoxy}butanoic acid × 2 SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；298 K；3.2 M sulfate/phosphate precipitant, pH 6.8, LIQUID DIFFUSION, temperature 298K
Resolution 1.70 Å R-free 0.205
4ROM Deoxyhemoglobin in complex with imidazolylacryloyl derivatives Deposited 2014-10-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 3U8 4-{2-chloro-4-[3-(1H-imidazol-2-yl)propanoyl]phenoxy}butanoic acid × 2 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；298 K；3.2 M sulfate/phosphate precipitant, pH 6.8, LIQUID DIFFUSION, temperature 298K
Resolution 1.90 Å R-free 0.248
4WJG Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin Deposited 2014-09-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 10 PDB declaration: Decameric
Chain A 2–142（141 aa）
Chain F 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；277 K；15% Polyethylene glycol (PEG) 1500, 0.1M Bis-Tris
Resolution 3.10 Å R-free 0.271
4WJG Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin Deposited 2014-09-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Other combination Heteromer；Protein × 10 PDB declaration: Decameric
Chain K 2–142（141 aa）
Chain P 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；277 K；15% Polyethylene glycol (PEG) 1500, 0.1M Bis-Tris
Resolution 3.10 Å R-free 0.271
4WJG Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin Deposited 2014-09-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Other combination Heteromer；Protein × 10 PDB declaration: Decameric
Chain U 2–142（141 aa）
Chain Z 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；277 K；15% Polyethylene glycol (PEG) 1500, 0.1M Bis-Tris
Resolution 3.10 Å R-free 0.271
4X0L Human haptoglobin-haemoglobin complex Deposited 2014-11-21 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 GOL GLYCEROL × 2 SO4 SULFATE ION × 1 CAC CACODYLATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M NaCl, 0.1 M sodium cacodylate pH 6.5 and 2 M ammonium sulphate
Resolution 2.05 Å R-free 0.224
4XS0 Human methemoglobin in complex with the second and third NEAT domains of IsdH(F365Y/A369F/Y642A) from Staphylococcus aureus Deposited 2015-01-21 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CL CHLORIDE ION × 3 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；0.2 M K/Na tartrate, 0.1 M tri-sodium citrate pH 5.6, 2 M ammonium sulfate. Cryoprotected in 20% glycerol.
Resolution 2.55 Å R-free 0.287
5E29 Crystal Structure of Deoxygenated Hemoglobin in Complex with an Allosteric Effector and Nitric Oxide Deposited 2015-09-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded NO NITRIC OXIDE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 5JN 2-(nitrooxy)ethyl 2-(4-{2-[(3,5-dimethylphenyl)amino]-2-oxoethyl}phenoxy)-2-methylpropanoate × 1 RQ3 2-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID × 2 NO3 NITRATE ION × 2 CAC CACODYLATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；295 K；0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate trihydrate, pH 6.5, 30% w/v PEG8000, anaerobic conditions
Resolution 1.85 Å R-free 0.253
5E6E Crystal Structure of Carbonmonoxy Sickle Hemoglobin in R-State Conformation Deposited 2015-10-09 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 4 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.6；293 K；3.2 M phosphate
Resolution 1.76 Å R-free 0.243
5E83 CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT440, CO-CRYSTALLIZATION EXPERIMENT Deposited 2015-10-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 5L7 2-methyl-3-({2-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-3-yl}methoxy)phenol × 1 GOL GLYCEROL × 3 UNL UNKNOWN LIGAND × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.4；294 K；0.1M HEPES, 25% PEG4000, PH 7.4, 40 MM NACL
Resolution 1.80 Å R-free 0.207
5EE4 The crystal structure of HpuA from Kingella denitrificans in complex with human haemoglobin Deposited 2015-10-22 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 2–142（141 aa）
Not recorded GOL GLYCEROL × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.8；277 K；100 mM Hepes, 18 % Peg 4,000, 10 % Isopropanol
Resolution 2.30 Å R-free 0.244
5EE4 The crystal structure of HpuA from Kingella denitrificans in complex with human haemoglobin Deposited 2015-10-22 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain E 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.8；277 K；100 mM Hepes, 18 % Peg 4,000, 10 % Isopropanol
Resolution 2.30 Å R-free 0.244
5HU6 Structure of the T. brucei haptoglobin-haemoglobin receptor bound to human haptolgobin-haemoglobin Deposited 2016-01-27 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；12.5% v/v MPD, 0.03 M NaBr, 0.03M NaI, 0.03M NaF, 0.1 M MES/imidazole pH 6.5, 12.5% w/v PEG 1000, 12.5% w/v PEG 3350
Resolution 2.90 Å R-free 0.226
5HY8 Glycation restrains allosteric transition in hemoglobin: The molecular basis of oxidative stress under hyperglycemic conditions in diabetes Deposited 2016-02-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 FRU beta-D-fructofuranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；PEG 4000
Resolution 2.30 Å R-free 0.244
5HY8 Glycation restrains allosteric transition in hemoglobin: The molecular basis of oxidative stress under hyperglycemic conditions in diabetes Deposited 2016-02-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 FRU beta-D-fructofuranose × 2 GLC alpha-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；PEG 4000
Resolution 2.30 Å R-free 0.244
5HY8 Glycation restrains allosteric transition in hemoglobin: The molecular basis of oxidative stress under hyperglycemic conditions in diabetes Deposited 2016-02-01 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain S 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；PEG 4000
Resolution 2.30 Å R-free 0.244
5JDO T. congolense haptoglobin-haemoglobin receptor in complex with haemoglobin Deposited 2016-04-17 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain C 2–142（141 aa）
Chain E 2–141（140 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；0.1 M sodium citrate pH 5, 8% w/v PEG 8000
Resolution 3.20 Å R-free 0.235
5KDQ Deoxyhemoglobin in Complex with an Aryloxyalkanoic acid Deposited 2016-06-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PO4 PHOSPHATE ION × 2 KOH 3-[2-chloranyl-4-(1~{H}-imidazol-2-yl)phenoxy]propanoic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；3.2 M Sulfate/phosphate precipitant, pH 6.8, LIQUID DIFFUSION
Resolution 2.15 Å R-free 0.257
5KSI Crystal structure of deoxygenated hemoglobin in complex with sphingosine phosphate and 2,3-Bisphosphoglycerate Deposited 2016-07-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 S1P (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate × 5 DG2 (2R)-2,3-diphosphoglyceric acid × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate trihydrate, pH 6.5 and 30% PEG 8000
Resolution 1.80 Å R-free 0.220
5KSJ Crystal structure of deoxygenated hemoglobin in complex with Sphingosine phosphate Deposited 2016-07-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 S1P (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate trihydrate, pH 6.5 and 30% PEG 8000
Resolution 2.40 Å R-free 0.287
5NI1 CryoEM structure of haemoglobin at 3.2 A determined with the Volta phase plate Deposited 2017-03-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.20 Å
5SW7 Structure of the Human Hemoglobin Mutant Hb Providence (A-Gly-C:V1M; B,D:V1M,K82D; Ferrous, carbonmonoxy bound) Deposited 2016-08-08 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Mutation：V1M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；296 K；2.5M sodium/potassium phosphate
Resolution 1.85 Å R-free 0.222
5U3I CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT compound 31 Deposited 2016-12-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 7SJ 2-methoxy-5-({2-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-3-yl}methoxy)pyridine-4-carbaldehyde × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；100 mM Hepes pH 7.4 20 mM NaCl 30 % PEG 3350
Resolution 1.95 Å R-free 0.253
5UCU STRUCTURAL AND MECHANISTIC INSIGHTS INTO HEMOGLOBIN-CATALYZED HYDROGEN SULFIDE OXIDATION AND THE FATE OF POLYSULFIDE PRODUCTS Deposited 2016-12-22 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 H2S HYDROSULFURIC ACID × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293.15 K；10% Toluene, 2.3 M K2HPO4/NH2PO4 pH, 7.2.
Resolution 1.80 Å R-free 0.222
5UFJ Crystal Structure of Carbonmonoxy Hemoglobin S (Liganded Sickle Cell Hemoglobin) Complexed with GBT Compound 6 Deposited 2017-01-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 86M 5-[(imidazo[1,2-a]pyridin-8-yl)methoxy]-2-methoxypyridine-4-carbaldehyde × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；0.1 M Hepes pH 7.4, 40 mM NaCl, 29 % PEG3350
Resolution 2.05 Å R-free 0.254
5URC Design, Synthesis, Functional and Biological Evaluation of Ether and Ester Derivatives of the Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease Deposited 2017-02-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 8MV (5-formylfuran-2-yl)methyl acetate × 1 FUX 5-HYDROXYMETHYL-FURFURAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.4；298 K；25% PEG4000, 0.1 M Hepes, 40 mM Sodium Chloride
Resolution 1.85 Å R-free 0.223
5VMM Staphylococcus aureus IsdB bound to human hemoglobin Deposited 2017-04-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；298 K；0.1 M malonic acid pH 5.5, 2.2 M ammonium sulfate
Resolution 3.60 Å R-free 0.302
5WOG Human Hemoglobin immersed in Liquid Oxygen for 1 minute Deposited 2017-08-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 3–139（137 aa）
Chain B 3–139（137 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277.15 K；1 mL of 40 mg/mL hemoglobin + 2.65 M (final concentration) phosphate buffer, topped with 100 uL toluene
Resolution 1.54 Å R-free 0.206
5WOH Human Hemoglobin Immersed in Liquid Oxygen for 20 seconds Deposited 2017-08-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 3–139（137 aa）
Chain C 3–139（137 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277.15 K；1 mL of 40 mg/mL hemoglobin + 2.65 M (final concentration) phosphate buffer, topped with 100 uL toluene
Resolution 1.58 Å R-free 0.207
5X2R Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 10 mM phosphate pH 6.9. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.70 Å R-free 0.306
5X2R Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 10 mM phosphate pH 6.9. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.70 Å R-free 0.306
5X2R Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 10 mM phosphate pH 6.9. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain I 2–142（141 aa）
Chain K 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.70 Å R-free 0.306
5X2S Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 6.5. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.39 Å R-free 0.288
5X2S Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 6.5. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.39 Å R-free 0.288
5X2S Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 6.5. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain I 2–142（141 aa）
Chain K 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 PEM 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.39 Å R-free 0.288
5X2T Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 7.2. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.64 Å R-free 0.277
5X2T Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 7.2. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.64 Å R-free 0.277
5X2T Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 7.2. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain I 2–142（141 aa）
Chain K 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 PEM 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.64 Å R-free 0.277
5X2U Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 80 mM phosphate pH 6.7. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.53 Å R-free 0.274
5X2U Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 80 mM phosphate pH 6.7. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.53 Å R-free 0.274
5X2U Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 80 mM phosphate pH 6.7. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain I 2–142（141 aa）
Chain K 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.53 Å R-free 0.274
6BB5 Human Oxy-Hemoglobin Deposited 2017-10-16 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 3–141（139 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；1 mL 40 mg/mL hemoglobin + 2.65 M (final concentration) phosphate buffer, topped with 100 uL toluene
Resolution 2.28 Å R-free 0.242
6BNR Carbonmonoxy hemoglobin in complex with the antisickling agent 5-methoxy-2-(pyridin-2-ylmethoxy)benzaldehyde (INN310) Deposited 2017-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 E0J 2-[(4-methoxy-2-methylphenoxy)methyl]pyridine × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.4；298 K；25% PEG 6000, 0.1M HEPES (pH 7.4)
Resolution 1.95 Å R-free 0.264
6BWP Crystal structure of Deoxy Hemoglobin in complex with beta Cys93 modifying agent, TD3 Deposited 2017-12-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 EBJ 1H-1,2,3-triazole-5-thiol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.6；293 K；3.4M Na Phosphate/NH4 Sulfate
Resolution 1.70 Å R-free 0.197
6BWU Crystal structure of carboxyhemoglobin in complex with beta Cys93 modifying agent, TD3 Deposited 2017-12-15 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 EBJ 1H-1,2,3-triazole-5-thiol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.6；293 K；3.2M Na/K Phosphate
Resolution 2.00 Å R-free 0.265
6DI4 Rational Modification of Vanillin Derivatives to Stereospecifically Destabilize Sickle Hemoglobin Polymer Formation Deposited 2018-05-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GJ1 {6-[(4-methoxy-2-methylphenoxy)methyl]pyridin-2-yl}methanol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.4；298 K；10-20% PEG6000, 100mM Hepes pH 7.4
Resolution 1.90 Å R-free 0.249
6HAL Human carbonmonoxy hemoglobin SFX dataset Deposited 2018-08-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 3–141（139 aa）
Chain C 3–141（139 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7；293 K；batch crystallization, using 1.6 M Na/K phosphate, neutal pH as precipitant
Resolution 2.20 Å R-free 0.211
6HBW Crystal structure of deoxy-human hemoglobin beta6 glu->trp Deposited 1998-09-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–141（141 aa）
Chain C 1–141（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；PROTEIN WAS RESUSPENDED IN 30 MM PHOSPHATE BUFFER, PH 7.0, DEOXYGENATED AND CONCENTRATED TO 160 MG/ML. PROTEIN WAS CRYSTALLIZED IN AN ANAEROBIC CHAMBER IN TUBE CONTAINING 10 UL PROTEIN SOLUTION, 5 UL CITRATE BUFFER (PH 4.0), AND 4UL OF 33% PEG 8K.
Resolution 2.00 Å R-free 0.264
6HK2 Crystal structure of ferric R-state human methemoglobin bound to maleimide-deferoxamine bifunctional chelator (DFO) Deposited 2018-09-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 1 SO4 SULFATE ION × 7 G7Z 3-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]-~{N}-methyl-propanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；293 K；2.4 M (NH4)2SO4, 0.23 M (NH4)2HPO4, 0.07 M (NH4)H2PO4
Resolution 1.55 Å R-free 0.212
6KA9 Crosslinked alpha(Fe-CO)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-06-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；18%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.40 Å R-free 0.191
6KA9 Crosslinked alpha(Fe-CO)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-06-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；18%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.40 Å R-free 0.191
6KAE Crosslinked alpha(Fe-CO)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-06-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 8 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；18%w/v PEG3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.45 Å R-free 0.200
6KAE Crosslinked alpha(Fe-CO)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-06-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 8 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；18%w/v PEG3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.45 Å R-free 0.200
6KAH Crosslinked alpha(Ni)-beta(Fe-CO) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-06-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；20%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.45 Å R-free 0.196
6KAH Crosslinked alpha(Ni)-beta(Fe-CO) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-06-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；20%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.45 Å R-free 0.196
6KAI Crosslinked alpha(Ni)-beta(Fe) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-06-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 CMO CARBON MONOXIDE × 7 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；20%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.45 Å R-free 0.202
6KAI Crosslinked alpha(Ni)-beta(Fe) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-06-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 CMO CARBON MONOXIDE × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；20%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.45 Å R-free 0.202
6KAO Carbonmonoxy human hemoglobin C in the R quaternary structure at 95 K: Dark Deposited 2019-06-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
Resolution 1.40 Å R-free 0.211
6KAP Carbonmonoxy human hemoglobin C in the R quaternary structure at 95 K: Light Deposited 2019-06-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
Resolution 1.45 Å R-free 0.211
6KAQ Carbonmonoxy human hemoglobin C in the R quaternary structure at 140 K: Dark Deposited 2019-06-24 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
Resolution 1.50 Å R-free 0.220
6KAR Carbonmonoxy human hemoglobin C in the R quaternary structure at 140 K: Light Deposited 2019-06-24 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
Resolution 1.60 Å R-free 0.226
6KAS Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 95 K: Dark Deposited 2019-06-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 5.8；293 K；18%w/v PEG6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
Resolution 1.65 Å R-free 0.202
6KAT Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 95 K: Light Deposited 2019-06-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 5.8；293 K；18%w/v PEG 6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
Resolution 1.70 Å R-free 0.203
6KAU Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 140 K: Dark Deposited 2019-06-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 5.8；293 K；18%w/v PEG6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
Resolution 1.60 Å R-free 0.213
6KAV Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 140 K: Light Deposited 2019-06-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 5.8；293 K；18%w/v PEG6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
Resolution 1.70 Å R-free 0.205
6KYE The crystal structure of recombinant human adult hemoglobin Deposited 2019-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–142（142 aa）
Chain C 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6；293 K；NaCl, PEG3350, MES
Resolution 2.28 Å R-free 0.268
6KYE The crystal structure of recombinant human adult hemoglobin Deposited 2019-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 1–142（142 aa）
Chain G 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6；293 K；NaCl, PEG3350, MES
Resolution 2.28 Å R-free 0.268
6KYE The crystal structure of recombinant human adult hemoglobin Deposited 2019-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain I 1–142（142 aa）
Chain K 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6；293 K；NaCl, PEG3350, MES
Resolution 2.28 Å R-free 0.268
6L5V Carbonmonoxy human hemoglobin C in the R quaternary structure at 95 K: Light (2 min) Deposited 2019-10-24 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
Resolution 1.45 Å R-free 0.213
6L5W Carbonmonoxy human hemoglobin C in the R quaternary structure at 140 K: Light (2 min) Deposited 2019-10-24 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
Resolution 1.50 Å R-free 0.215
6L5X Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 95 K: Light (2 min) Deposited 2019-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 5.8；293 K；18%w/v PEG 6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
Resolution 1.65 Å R-free 0.207
6L5Y Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 140 K: Light (2 min) Deposited 2019-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 5.8；293 K；18%w/v PEG 6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
Resolution 1.65 Å R-free 0.206
6LCW Crosslinked alpha(Ni)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-11-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 4 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；1.0% (w/v) protein solution that contains 18% (w/v) PEG3350, 0.15 M dipotassium sulfate, 50 mM citrate-ammonium buffer (pH 6.6)
Resolution 1.40 Å R-free 0.218
6LCW Crosslinked alpha(Ni)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-11-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 4 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；1.0% (w/v) protein solution that contains 18% (w/v) PEG3350, 0.15 M dipotassium sulfate, 50 mM citrate-ammonium buffer (pH 6.6)
Resolution 1.40 Å R-free 0.218
6LCX Crosslinked alpha(Ni)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-11-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 4 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；1.0% (w/v) protein solution that contains 18% (w/v) PEG 3350, 0.15 M dipotassium sulfate, 50 mM citrate-ammonium buffer (pH 6.6)
Resolution 1.40 Å R-free 0.216
6LCX Crosslinked alpha(Ni)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-11-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 4 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；1.0% (w/v) protein solution that contains 18% (w/v) PEG 3350, 0.15 M dipotassium sulfate, 50 mM citrate-ammonium buffer (pH 6.6)
Resolution 1.40 Å R-free 0.216
6NBC human methemoglobin state 1 determined using single-particle cryo-EM at 200 keV Deposited 2018-12-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–141（140 aa）
Chain C 2–141（140 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Sample was manually blotted for 4-5 seconds using Whatman No. 1 filter paper immediately prior to plunge-freezing.
Resolution 2.80 Å
6NBD Human methemoglobin state 2 determined using single-particle cryo-EM at 200 keV Deposited 2018-12-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–141（140 aa）
Chain C 2–141（140 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；Sample was manually blotted for 4-5 seconds using Whatman No. 1 filter paper immediately prior to plunge-freezing.
Resolution 3.20 Å
6NQ5 human (alpha met/beta hemichrome) hemoglobin with S-nitrosation at beta-Cys93 Deposited 2019-01-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FE FE (III) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；298 K；sodium phosphate, potassium phosphate, toluene
Resolution 1.85 Å R-free 0.282
6TB2 Structure of human haptoglobin-hemoglobin bound to S. aureus IsdH Deposited 2019-10-31 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M sodium citrate tribasic dihydrate, 20 % w/v PEG 3350
Resolution 2.90 Å R-free 0.270
6XD9 Carbonmonoxy hemoglobin in complex with the antisickling agent 2-hydroxy-6-((6-(hydroxymethyl)pyridin-2-yl)methoxy)benzaldehyde (VZHE039) Deposited 2020-06-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 V39 3-{[6-(hydroxymethyl)pyridin-2-yl]methoxy}-2-methylphenol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.4；298 K；25% PEG 6000, 0.1M HEPES
Resolution 2.10 Å R-free 0.258
6XDT Carbonmonoxy hemoglobin in complex with the antisickling agent methyl 5-((2-formyl-4-methoxyphenoxy)methyl)picolinate Deposited 2020-06-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 V1M methyl 5-[(4-methoxy-2-methylphenoxy)methyl]pyridine-2-carboxylate × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.4；298 K；25% PEG 6000, 100 mM HEPES buffer
Resolution 1.90 Å R-free 0.239
6XE7 Carbonmonoxy hemoglobin in complex with the antisickling agent methyl 2-((2-formyl-3-hydroxyphenoxy)methyl)nicotinate Deposited 2020-06-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 V2D methyl 2-[(3-hydroxy-2-methylphenoxy)methyl]pyridine-3-carboxylate × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.4；298 K；25% PEG 6000, 10 mM HEPES
Resolution 2.00 Å R-free 0.251
7AET Pressure wave-exposed human hemoglobin: probe only data (3500 indexed images) Deposited 2020-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain AAA 3–141（139 aa）
Chain CCC 3–141（139 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；293 K；3.2 M NaH2PO4/ 3.2 M K2HPO4 in a 2:1 ratio
Resolution 2.53 Å R-free 0.288
7AEU Pressure wave-exposed human hemoglobin: probe only data (5500 indexed images) Deposited 2020-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain AAA 3–141（139 aa）
Chain CCC 3–141（139 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；293 K；3.2 M NaH2PO4/ 3.2 M K2HPO4 in a 2:1 ratio
Resolution 2.54 Å R-free 0.273
7AEV Pressure wave-exposed human hemoglobin: pump/probe data (3500 indexed images) Deposited 2020-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain AAA 3–141（139 aa）
Chain CCC 3–141（139 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；293 K；3.2 M NaH2PO4/ 3.2 M K2HPO4 in a 2:1 ratio
Resolution 2.77 Å R-free 0.273
7CUE Crystal structure of HID2 bound to human Hemoglobin Deposited 2020-08-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain A 1–142（142 aa）
Chain C 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；293.15 K；23% PEG 3350 (w/v), 100mM ammonium sulfate, 100mM BIS-TRIS
Resolution 2.75 Å R-free 0.259
7DY3 High resolution crystal structure of hemoglobin M Iwate. Deposited 2021-01-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；25%w/v PEG 3350, 0.1M HEPES-NaOH buffer, 0.2M lithium sulfate, pH 7.5
Resolution 1.40 Å R-free 0.193
7DY3 High resolution crystal structure of hemoglobin M Iwate. Deposited 2021-01-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；25%w/v PEG 3350, 0.1M HEPES-NaOH buffer, 0.2M lithium sulfate, pH 7.5
Resolution 1.40 Å R-free 0.193
7DY4 High resolution crystal structure of hemoglobin M Boston. Deposited 2021-01-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；20% w/v PEG 3350, 0.1M Bistris-HCl buffer, 0.2M magnesium chloride, pH 6.0
Resolution 1.30 Å R-free 0.186
7DY4 High resolution crystal structure of hemoglobin M Boston. Deposited 2021-01-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；20% w/v PEG 3350, 0.1M Bistris-HCl buffer, 0.2M magnesium chloride, pH 6.0
Resolution 1.30 Å R-free 0.186
7JJQ Human Hemoglobin in Complex with Nitrosoamphetamine Deposited 2020-07-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 1 K7M (2R)-N-hydroxy-1-phenylpropan-2-amine × 3 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.74；298 K；3.2M Na/K phosphate buffer
Resolution 2.15 Å R-free 0.286
7JXZ Structure of HbA with compound (S)-4 Deposited 2020-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 5 VOJ 3-{(1S)-1-[5-fluoro-2-(1H-pyrazol-1-yl)phenyl]ethoxy}-5-(3-methyl-1H-pyrazol-4-yl)pyridin-2-amine × 2 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.1 M Tris-HCl, pH 8.0, 0.2 M lithium sulfate, 30-32% PEG3350
Resolution 2.23 Å R-free 0.247
7JY0 Structure of HbA with compound 9 Deposited 2020-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 6 VOM 2-amino-3-{(1S)-1-[5-fluoro-2-(1H-pyrazol-1-yl)phenyl]ethoxy}quinoline-6-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl, pH 8.0, 0.2 M lithium sulfate, 30-32% PEG3350
Resolution 1.63 Å R-free 0.197
7JY1 Structure of HbA with compound 19 Deposited 2020-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 7 VOP [6-{(1S)-1-[(2-amino-6-fluoroquinolin-3-yl)oxy]ethyl}-5-(1H-pyrazol-1-yl)-1H-indazol-1-yl]acetic acid × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl, pH 8.0, 0.2 M lithium sulfate, 30-32% PEG3350
Resolution 1.59 Å R-free 0.193
7JY3 Structure of HbA with compound 23 (PF-07059013) Deposited 2020-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 5 VUD 6-{(1S)-1-[(2-amino-6-fluoroquinolin-3-yl)oxy]ethyl}-5-(1H-pyrazol-1-yl)pyridin-2(1H)-one × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl, pH 8.0, 0.2 M lithium sulfate, 30-32% PEG3350
Resolution 1.48 Å R-free 0.207
7K4M Crystal structure of MetAP2 Modified Hemoglobin S Deposited 2020-09-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–142（142 aa）
Chain C 1–142（142 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.6；293 K；0.2M Na acetate/0.1M Na cacodylate, 30% PEG-8000
Resolution 2.50 Å R-free 0.323
7K4M Crystal structure of MetAP2 Modified Hemoglobin S Deposited 2020-09-15 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 1–142（142 aa）
Not recorded CMO CARBON MONOXIDE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.6；293 K；0.2M Na acetate/0.1M Na cacodylate, 30% PEG-8000
Resolution 2.50 Å R-free 0.323
7K4M Crystal structure of MetAP2 Modified Hemoglobin S Deposited 2020-09-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain G 1–142（142 aa）
Chain I 1–142（142 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.6；293 K；0.2M Na acetate/0.1M Na cacodylate, 30% PEG-8000
Resolution 2.50 Å R-free 0.323
7PCF Human methemoglobin bound to Staphylococcus aureus hemophore IsdB Deposited 2021-08-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2；CHAPSO was added immediately before plunge freezing to overcome preferred orientation of the particles in the vitreous ice.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.82 Å
7PCH Human carboxyhemoglobin bound to Staphylococcus aureus hemophore IsdB - 1:2 complex Deposited 2021-08-03 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2；CHAPSO was added immediately before plunge freezing to overcome preferred orientation of the particles in the vitreous ice.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.89 Å
7PCQ Human carboxyhemoglobin bound to Staphylococcus aureus hemophore IsdB - 1:1 complex Deposited 2021-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2；CHAPSO was added immediately before plunge freezing to overcome preferred orientation of the particles in the vitreous ice.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.62 Å
7QU4 Recombinant Human Fetal Hemoglobin mutant - alpha subunit mutations K11E,K56E,N78D,K90E Deposited 2022-01-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–142（142 aa）
Mutation：K11E,K56E,N78D,K90E HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293.15 K；0.2 M Sodium fluoride, 0.1 M Bis-Tris propane pH 6.5, 20 % (w/v) PEG 3350
Resolution 1.66 Å R-free 0.219
7QU4 Recombinant Human Fetal Hemoglobin mutant - alpha subunit mutations K11E,K56E,N78D,K90E Deposited 2022-01-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–142（142 aa）
Mutation：K11E,K56E,N78D,K90E HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293.15 K；0.2 M Sodium fluoride, 0.1 M Bis-Tris propane pH 6.5, 20 % (w/v) PEG 3350
Resolution 1.66 Å R-free 0.219
7UD7 Crystal structure of deoxygenated hemoglobin in complex with 5HMF-NO at 1.8 Angstrom Deposited 2022-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–142（142 aa）
Chain C 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MWC dihydroxy[(5-methylfuran-2-yl)methoxy]amine × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；3.2-3.6M Sulfate/phosphate precipitant, pH 6.5, ferrous citrate
Resolution 1.80 Å R-free 0.191
7UD8 Crystal structure of carbon monoxy Hemoglobin in complex with 5HMF at 1.8 Angstrom Deposited 2022-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–142（142 aa）
Chain C 1–142（142 aa）
Not recorded OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MW0 (5-methylfuran-2-yl)methanol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；3.2-3.6M Sulfate/phosphate precipitant, pH 6.5, ferrous citrate
Resolution 1.80 Å R-free 0.228
7UF6 Crystal structure of liganded Hb with the 5-HMF analog, MMA509 Deposited 2022-03-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–142（142 aa）
Chain C 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 N1X (2S)-2-(5-methylfuran-2-yl)oxane × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；293 K；30 mg/dL of CO-ligated Hb crystallized using 10-20% PEG 6000, 100 mM Hepes, pH 7.4
Resolution 2.00 Å R-free 0.239
7UF7 Crystal structure of liganded Hb with the 5-HMF analog, MMA503 Deposited 2022-03-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–142（142 aa）
Chain C 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 N2Q (5P)-5-(5-methylfuran-2-yl)-1H-pyrazole × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；293 K；30 mg/dL of CO-ligated Hb crystallized using 10-20% PEG 6000, 100 mM Hepes, pH 7.4
Resolution 2.00 Å R-free 0.223
7UVB CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT021601 Deposited 2022-04-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FOR FORMYL GROUP × 4 OHF 2-hydroxy-6-({(3S)-4-[2-(2-hydroxyethyl)pyridine-3-carbonyl]morpholin-3-yl}methoxy)benzaldehyde × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；296 K；100 mM Hepes pH 7.4, 20 mM NaCl, 28-33% PEG 3350
Resolution 2.05 Å R-free 0.277
7VDE 3.6 A structure of the human hemoglobin Deposited 2021-09-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–142（142 aa）
Chain C 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
7XGY cryo-EM structure of hemoglobin Deposited 2022-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–142（142 aa）
Chain C 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
8DOV Crystal structure of the Shr Hemoglobin Interacting Domain 2 (HID2) in complex with Hemoglobin Deposited 2022-07-14 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 2–142（141 aa） Fragment：Shr_HID2
Chain C 2–142（141 aa） Fragment：Shr_HID2
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；295 K；11% PEG-6000, 100mM sodium acetate, 240mM lithium chloride
Resolution 2.10 Å R-free 0.238
8DOV Crystal structure of the Shr Hemoglobin Interacting Domain 2 (HID2) in complex with Hemoglobin Deposited 2022-07-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain E 2–142（141 aa） Fragment：Shr_HID2
Chain G 2–142（141 aa） Fragment：Shr_HID2
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；295 K；11% PEG-6000, 100mM sodium acetate, 240mM lithium chloride
Resolution 2.10 Å R-free 0.238
8EGI X-ray structure of carbonmonoxy hemoglobin in complex with VZHE039-NO Deposited 2022-09-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–142（142 aa）
Chain C 1–142（142 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 VZN {6-[(3-hydroxy-2-methylphenoxy)methyl]pyridin-2-yl}methyl nitrate × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；30 mg/dL of CO-ligated Hb crystallized using 10-20% PEG 6000, 100 mM Hepes, pH 7.4
Resolution 2.30 Å R-free 0.251
8FDK Phenylhydroxylamine in Reaction with Human Hemoglobin Deposited 2022-12-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa） Fragment：Shr_HID2
Chain C 2–142（141 aa） Fragment：Shr_HID2
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NBE NITROSOBENZENE × 5 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.81；298 K；3.2 M sodium/potassium phosphate
Resolution 1.89 Å R-free 0.246
8FDL Human Hemoglobin with Nitrosochloramphenicol Deposited 2022-12-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa） Fragment：Shr_HID2
Chain C 2–142（141 aa） Fragment：Shr_HID2
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 8 GOL GLYCEROL × 4 XQU nitrosochloramphenicol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.4；293 K；3.6 M ammonium phosphate/sulfate
Resolution 1.75 Å R-free 0.210
8FDM Human Hemoglobin in Complex with Nitrosomethane Deposited 2022-12-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa） Fragment：Shr_HID2
Chain C 2–142（141 aa） Fragment：Shr_HID2
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 5 MBN TOLUENE × 2 NSM NITROSOMETHANE × 2 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；298 K；3.2 M sodium/potassium phosphate
Resolution 1.91 Å R-free 0.253
8FDN Human Hemoglobin with N-tertbutylhydroxylamine Deposited 2022-12-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded GOL GLYCEROL × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 XQZ N-T-Butylhydroxylamine × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；298 K；3.2 M sodium/potassium phosphate
Resolution 2.20 Å R-free 0.291
8VYL The structure of Human Hemoglobin in Complex with Nanobody BtNbE11 Deposited 2024-02-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 1–142（142 aa）
Chain C 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ACE ACETYL GROUP × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.1-0.3M NH4 Acet. pH 5.5, 0.1-0.3M Na Acet., 25% w/v PEG3350
Resolution 2.02 Å R-free 0.266
8WJ0 cryo-EM structure of human haemoglobin in carbonmonoxy form Deposited 2023-09-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.24 Å
8WJ1 cryo-EM structure of human haemoglobin in oxy form Deposited 2023-09-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.27 Å
8WJ2 cryo-EM structure of human haemoglobin in deoxy form Deposited 2023-09-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.35 Å
8WXW Falcilysin in complex with hemoglobin alpha chain peptide Deposited 2023-10-30 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain P 35–48（14 aa）
Not recorded GOL GLYCEROL × 4 EDO 1,2-ETHANEDIOL × 1 ZN ZINC ION × 1 CL CHLORIDE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；4% w/v PEG 1500, 20% v/v glycerol
Resolution 1.86 Å R-free 0.210
8XMP Structure of CD163 in complex with Hb-Hp Deposited 2023-12-27 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric
Chain C 1–142（142 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 10 CA CALCIUM ION × 23 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.11 Å
8XMQ Structure of dimeric CD163 in complex with Hb-Hp Deposited 2023-12-27 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric
Chain C 1–142（142 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 CA CALCIUM ION × 12 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.21 Å
8XMW Local refinement of Hb-Hp bind to CD163 Deposited 2023-12-28 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric
Chain A 1–142（142 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 CA CALCIUM ION × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.94 Å
9AV9 R2-state HbG-Makassar hemoglobin Deposited 2024-03-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded GOL GLYCEROL × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8；298 K；0.1 M TRIS pH 8.0; 26-36% (v/v) PEG 6,000
Resolution 1.94 Å R-free 0.222
9AYZ T-state HbG Makassar hemoglobin Deposited 2024-03-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；298 K；0.055 M Citric acid, 0.045 M Bis-Tris propane, pH 4.5, 22% PEG 3,350 under low oxygen conditions on an MBraun anaerobic glove box
Resolution 2.24 Å R-free 0.259
9AYZ T-state HbG Makassar hemoglobin Deposited 2024-03-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 2–142（141 aa）
Chain G 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；298 K；0.055 M Citric acid, 0.045 M Bis-Tris propane, pH 4.5, 22% PEG 3,350 under low oxygen conditions on an MBraun anaerobic glove box
Resolution 2.24 Å R-free 0.259
9CQM Human OxyHb (C1 symmetry) obtained using the SPT Labtech chameleon In the presence of 25 uM sodium dithionite under Al's oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 3–141（139 aa）
Chain C 3–141（139 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.55 Å
9CQN Human OxyHb (C2 symmetry) obtained using the SPT Labtech chameleon In the presence of 25 uM sodium dithionite under Al's oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 3–141（139 aa）
Chain C 3–141（139 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.37 Å
9CQO Human metHb (C1 symmetry) obtained using the SPT Labtech chameleon Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–141（140 aa）
Chain C 2–141（140 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 3.01 Å
9CQP Human metHb (C2 symmetry) obtained using the SPT Labtech chameleon Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–141（140 aa）
Chain C 2–141（140 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.78 Å
9CQQ Human metHb (C1 symmetry) obtained using the SPT Labtech chameleon under Al's Oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–141（140 aa）
Chain C 2–141（140 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.91 Å
9CQR Human metHb (C2 symmetry) obtained using the SPT Labtech chameleon under Al's Oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–141（140 aa）
Chain C 2–141（140 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.70 Å
9CQS Human OxyHb (C1 symmetry) obtained using the SPT Labtech chameleon In the presence of 5 mM sodium dithionite under Al's oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 3–141（139 aa）
Chain C 3–141（139 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.52 Å
9CQT Human OxyHb (C2 symmetry) obtained using the SPT Labtech chameleon In the presence of 5 mM sodium dithionite under Al's oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 3–141（139 aa）
Chain C 3–141（139 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.37 Å
9CQU Human OxyHb (C1 symmetry) obtained using the SPT Labtech chameleon In the presence of 20 mM sodium dithionite under Al's oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 3–141（139 aa）
Chain C 3–141（139 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.72 Å
9CQV Human DeoxyHb (C1 symmetry) obtained using the SPT Labtech chameleon In the presence of 60 mM sodium dithionite under Al's oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–141（140 aa）
Chain C 2–141（140 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.75 Å
9CQW Human DeoxyHb (C2 symmetry) obtained using the SPT Labtech chameleon In the presence of 60 mM sodium dithionite under Al's oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–141（140 aa）
Chain C 2–141（140 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.61 Å
9FHB Cryo-EM structure of human CD163 SRCR2-4 in complex with haptoglobin-hemoglobin Deposited 2024-05-27 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 CA CALCIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.87 Å
9FMU Cryo-EM structure of human CD163 SRCR1-9 in complex with haptoglobin-hemoglobin Deposited 2024-06-07 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain A 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 CA CALCIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.46 Å
9FNO Cryo-EM structure of human CD163 SRCR1-9 in complex with haptoglobin-hemoglobin Deposited 2024-06-10 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain A 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.20 Å
9HBA Crystal structure of C35 bound to Hem Deposited 2024-11-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–142（141 aa）
Chain C 2–142（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 6 A1ITR 4-[2-[[5-(1H-indol-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanoylamino]benzoic acid × 3 DMS DIMETHYL SULFOXIDE × 8 CMO CARBON MONOXIDE × 4 ACY ACETIC ACID × 2 SO4 SULFATE ION × 16 PGE TRIETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；3.0 M Ammonium sulfate; 1% (w/v) MPD
Resolution 1.51 Å R-free 0.215
9HEJ Dimeric CD163 bound to human haptoglobin-haemoglobin complex Deposited 2024-11-14 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric
Chain D 1–142（142 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 CA CALCIUM ION × 9 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.82 Å
9HEK Trimeric CD163 bound to human haptoglobin-haemoglobin complex Deposited 2024-11-14 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric
Chain D 1–142（142 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 CA CALCIUM ION × 19 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.15 Å
9NB6 Cryo-EM structure of the CD163/Hp(1-1)Hb complex Deposited 2025-02-13 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain D 1–142（142 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 CA CALCIUM ION × 23 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
9NB8 Cryo-EM structure of the CD163/HpSPHb complex Deposited 2025-02-13 Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain D 1–142（142 aa）
Not recorded CA CALCIUM ION × 21 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
9S3P Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 3IsdH(alpha2beta):Hbtet complex Deposited 2025-07-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain A 3–142（140 aa）
Chain C 3–142（140 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE；blot time 3 s
Resolution 3.10 Å
9S4F Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 4 right tail Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 3–142（140 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE；blot time 3 s
Resolution 4.20 Å
9S4I Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 0 left tail Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 3–142（140 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE；blot time 3 s
Resolution 4.00 Å
9S4J Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 0 right tail Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 3–142（140 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE；blot time 3 s
Resolution 4.10 Å
9S4K Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 4 left tail Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 3–142（140 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE；blot time 3 s
Resolution 4.00 Å
9SZW Human carboxyhemoglobin bound to full-length Staphylococcus aureus IsdH - IsdH:Hbdim complex Deposited 2025-10-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 3–142（140 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE；blot time 3 s
Resolution 3.14 Å
9TQD CD163 bound to haemoglobin Deposited 2025-12-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric
Chain D 1–142（142 aa）
Chain F 1–142（142 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 CA CALCIUM ION × 16 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
9VIB cryo-EM structure of human haemoglobin in the R2 conformation Deposited 2025-06-18 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.26 Å
9VIB cryo-EM structure of human haemoglobin in the R2 conformation Deposited 2025-06-18 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.26 Å
9VIB cryo-EM structure of human haemoglobin in the R2 conformation Deposited 2025-06-18 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.26 Å
9VIC cryo-EM structure of human haemoglobin in the R conformation Deposited 2025-06-18 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.45 Å
9VIC cryo-EM structure of human haemoglobin in the R conformation Deposited 2025-06-18 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.45 Å
9VIC cryo-EM structure of human haemoglobin in the R conformation Deposited 2025-06-18 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–142（142 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.45 Å

348 other PDB entries and 412 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name HBA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–141； UniProt 2–142

Hemoglobin subunit beta

OrganismNot specified

UniProt P68871

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 6 PDB declaration: hexameric（6） Consistent with protein copy count Chain B； UniProt 2–147 Not recorded Hemoglobin subunit alpha × 2 （P69905） Membrane protein × 2 （Q6NEE5） HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 6 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；20% PEG-2000 MME, 100 mM Tris, 240 mM TMAO Resolution 1.69 Å R-free 0.215

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9BCJ Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1A00 HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 TYR) MUTANT Deposited 1997-12-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–146（145 aa）
Chain D 2–146（145 aa）
Mutation：V1M, W37Y Mutation：V1M, W37Y HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；10.5% PEG 6000 10 MM POTASSIUM PHOSPHATE PH 7.0 100 MM POTASSIUM CHLORIDE 3 MM SODIUM DITHIONITE
Resolution 2.00 Å R-free 0.223
1A01 HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 ALA) MUTANT Deposited 1997-12-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–146（145 aa）
Chain D 2–146（145 aa）
Mutation：V1M, W37Y Mutation：V1M, W37Y HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；2.3 M AMMONIUM SULFATE 0.3 M AMMONIUM PHOSPHATE PH 6.5 10 MM FERROUS CITRATE
Resolution 1.80 Å R-free 0.223
1A0U HEMOGLOBIN (VAL BETA1 MET) MUTANT Deposited 1997-12-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–146（145 aa）
Chain D 2–146（145 aa）
Mutation：V1M Mutation：V1M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；10.5% PEG 6000 10 MM POTASSIUM PHOSPHATE PH 7.0 100 MM POTASSIUM CHLORIDE 3 MM SODIUM DITHIONITE
Resolution 2.14 Å R-free 0.239
1A0Z HEMOGLOBIN (VAL BETA1 MET) MUTANT Deposited 1997-12-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–146（145 aa）
Chain D 2–146（145 aa）
Mutation：V1M Mutation：V1M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；10.5% PEG 6000 10 MM POTASSIUM PHOSPHATE PH 7.0 100 MM POTASSIUM CHLORIDE 3 MM SODIUM DITHIONITE
Resolution 2.00 Å
1A3N DEOXY HUMAN HEMOGLOBIN Deposited 1998-01-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.220
1A3O ARTIFICIAL MUTANT (ALPHA Y42H) OF DEOXY HEMOGLOBIN Deposited 1998-01-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：CHAIN A, C, Y42H Mutation：CHAIN A, C, Y42H HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
1ABW DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN) Deposited 1997-01-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 2–146（145 aa）
Chain D 2–146（145 aa）
Mutation：CHAIN A IS COMPOSED OF TWO COPIES OF HEMOGLOBIN ALPHA CHAIN JOINED BY AN ADDITIONAL RESIDUE, GLY 142 Mutation：CHAIN A IS COMPOSED OF TWO COPIES OF HEMOGLOBIN ALPHA CHAIN JOINED BY AN ADDITIONAL RESIDUE, GLY 142 MET METHIONINE × 2 LEU LEUCINE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.2；pH 6.2
Resolution 2.00 Å R-free 0.232
1ABY CYANOMET RHB1.1 (RECOMBINANT HEMOGLOBIN) Deposited 1997-01-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 2–146（145 aa）
Chain D 2–146（145 aa）
Mutation：CHAIN A, V1M, CHAIN B, D, V1M, N108K Mutation：CHAIN A, V1M, CHAIN B, D, V1M, N108K CYN CYANIDE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5；pH 5.0
Resolution 2.60 Å R-free 0.278
1AJ9 R-STATE HUMAN CARBONMONOXYHEMOGLOBIN ALPHA-A53S Deposited 1997-05-16 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded PO4 PHOSPHATE ION × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch method；pH 6.7；PROTEIN WAS BATCH CRYSTALLIZED IN 2.5 M SODIUM/POTASSIUM PHOSPHATE, PH 6.7, AND 1% (W/V) CARBOXYHEMOGLOBIN., batch method
Resolution 2.20 Å
1B86 HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX Deposited 1999-02-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 DG2 (2R)-2,3-diphosphoglyceric acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.2
Resolution 2.50 Å
1BAB HEMOGLOBIN THIONVILLE: AN ALPHA-CHAIN VARIANT WITH A SUBSTITUTION OF A GLUTAMATE FOR VALINE AT NA-1 AND HAVING AN ACETYLATED METHIONINE NH2 TERMINUS Deposited 1992-05-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
1BBB A THIRD QUATERNARY STRUCTURE OF HUMAN HEMOGLOBIN A AT 1.7-ANGSTROMS RESOLUTION Deposited 1992-04-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.70 Å
1BIJ CROSSLINKED, DEOXY HUMAN HEMOGLOBIN A Deposited 1998-06-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；pH 7.0
Resolution 2.30 Å R-free 0.263
1BZ0 HEMOGLOBIN A (HUMAN, DEOXY, HIGH SALT) Deposited 1998-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；2.3 M AMMONIUM SULFATE 0.3 M AMMONIUM PHOSPHATE PH 6.5 10 MM FERROUS CITRATE
Resolution 1.50 Å R-free 0.208
1BZ1 HEMOGLOBIN (ALPHA + MET) VARIANT Deposited 1998-11-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；2.3 M AMMONIUM SULFATE 0.3 M AMMONIUM PHOSPHATE PH 6.5 10 MM FERROUS CITRATE
Resolution 1.59 Å R-free 0.224
1BZZ HEMOGLOBIN (ALPHA V1M) MUTANT Deposited 1998-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；2.3 M AMMONIUM SULFATE 0.3 M AMMONIUM PHOSPHATE PH 6.5 10 MM FERROUS CITRATE, pH 7.0
Resolution 1.59 Å R-free 0.214
1C7B DEOXY RHB1.0 (RECOMBINANT HEMOGLOBIN) Deposited 2000-02-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M,N108K Mutation：V1M,N108K HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；PERUTZ, J.CRYST.GROWTH 2(1968)54-56, pH 6.5
Resolution 1.80 Å R-free 0.234
1C7C DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN) Deposited 2000-02-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M,N108K Mutation：V1M,N108K HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；PERUTZ, J.CRYST.GROWTH 2(1968)54-56, pH 6.5
Resolution 1.80 Å R-free 0.227
1C7D DEOXY RHB1.2 (RECOMBINANT HEMOGLOBIN) Deposited 2000-02-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M,N108K Mutation：V1M,N108K HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；PERUTZ, J.CRYST.GROWTH 2(1968)54-56, pH 6.5
Resolution 1.80 Å R-free 0.240
1CBL THE 1.9 ANGSTROM STRUCTURE OF DEOXY-BETA4 HEMOGLOBIN: ANALYSIS OF THE PARTITIONING OF QUATERNARY-ASSOCIATED AND LIGAND-INDUCED CHANGES IN TERTIARY STRUCTURE Deposited 1993-02-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 1–146（146 aa）
Chain B 1–146（146 aa）
Chain C 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded SO4 SULFATE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1CBM THE 1.8 ANGSTROM STRUCTURE OF CARBONMONOXY-BETA4 HEMOGLOBIN: ANALYSIS OF A HOMOTETRAMER WITH THE R QUATERNARY STRUCTURE OF LIGANDED ALPHA2BETA2 HEMOGLOBIN Deposited 1993-02-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 1–146（146 aa）
Chain B 1–146（146 aa）
Chain C 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded SO4 SULFATE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.74 Å
1CLS CROSS-LINKED HUMAN HEMOGLOBIN DEOXY Deposited 1995-08-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 O OXYGEN ATOM × 2 SO4 SULFATE ION × 2 DEC SEBACIC ACID × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å
1CMY THE MUTATION BETA99 ASP-TYR STABILIZES Y-A NEW, COMPOSITE QUATERNARY STATE OF HUMAN HEMOGLOBIN Deposited 1992-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 3.00 Å
1COH STRUCTURE OF HAEMOGLOBIN IN THE DEOXY QUATERNARY STATE WITH LIGAND BOUND AT THE ALPHA HAEMS Deposited 1989-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 COH PROTOPORPHYRIN IX CONTAINING CO × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.90 Å
1DKE NI BETA HEME HUMAN HEMOGLOBIN Deposited 1999-12-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；294 K；24 MG/ML PROTEIN 21% PEG 1000 10MM POTASSIUM PHOSPHATE, 1MM IHP, 30MM SODIUM DITHIONITE, pH 7, VAPOR DIFFUSION, HANGING DROP
Resolution 2.10 Å R-free 0.280
1DXT HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI Deposited 1992-05-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.70 Å
1DXU HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI Deposited 1992-05-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–146（145 aa）
Chain D 2–146（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.70 Å
1DXV HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI Deposited 1992-05-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–146（145 aa）
Chain D 2–146（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.70 Å
1FN3 CRYSTAL STRUCTURE OF NICKEL RECONSTITUTED HEMOGLOBIN-A CASE FOR PERMANENT, T-STATE HEMOGLOBIN Deposited 2000-08-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.20
Resolution 2.48 Å R-free 0.324
1G9V HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXY HEMOGLOBIN COMPLEXED WITH A POTENT ALLOSTERIC EFFECTOR Deposited 2000-11-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 RQ3 2-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID × 2 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；Ammonium sulfate, ammonium phosphate, ferrous citrate, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 1.85 Å R-free 0.208
1GBU DEOXY (BETA-(C93A,C112G)) HUMAN HEMOGLOBIN Deposited 1996-01-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：CHAIN B, D, C93A, C112G Mutation：CHAIN B, D, C93A, C112G HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1GBV (ALPHA-OXY, BETA-(C112G)DEOXY) T-STATE HUMAN HEMOGLOBIN Deposited 1995-12-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：CHAIN B, D, C112G Mutation：CHAIN B, D, C112G HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å
1GLI DEOXYHEMOGLOBIN T38W (ALPHA CHAINS), V1G (ALPHA AND BETA CHAINS) Deposited 1996-02-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–146（145 aa）
Chain D 2–146（145 aa）
Mutation：V1M, CHAIN A, C, T38W Mutation：V1M, CHAIN A, C, T38W HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å
1GZX Oxy T State Haemoglobin - Oxygen bound at all four haems Deposited 2002-06-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；BATCH CRYSTALLISATION, OXYHB (75-90 MG/ML) IN 50MM POTASSIUM PHOSPHATE (PH 7.2), 22-28% PEG 8000 AND A 5 MOLAR EXCESS OF THE ALLOSTERIC EFFECTOR IHP
Resolution 2.10 Å R-free 0.221
1HAB CROSSLINKED HAEMOGLOBIN Deposited 1996-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 CIN 4-CARBOXYCINNAMIC ACID × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.30 Å
1HAC CROSSLINKED HAEMOGLOBIN Deposited 1996-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 NDD 2,6-DICARBOXYNAPHTHALENE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å
1HBA HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE Deposited 1992-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CL CHLORIDE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å
1HBB HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE Deposited 1992-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å
1HBS REFINED CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S. I. RESTRAINED LEAST-SQUARES REFINEMENT AT 3.0-ANGSTROMS RESOLUTION Deposited 1982-06-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 3.00 Å
1HBS REFINED CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S. I. RESTRAINED LEAST-SQUARES REFINEMENT AT 3.0-ANGSTROMS RESOLUTION Deposited 1982-06-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 1–146（146 aa）
Chain H 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 3.00 Å
1HCO THE STRUCTURE OF HUMAN CARBONMONOXY HAEMOGLOBIN AT 2.7 ANGSTROMS RESOLUTION Deposited 1979-08-07 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å
1HGA HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN Deposited 1991-10-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å
1HGB HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN Deposited 1991-10-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å
1HGC HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN Deposited 1991-10-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å
1HHO STRUCTURE OF HUMAN OXYHAEMOGLOBIN AT 2.1 ANGSTROMS RESOLUTION Deposited 1983-06-10 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded PO4 PHOSPHATE ION × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å
1IRD Crystal Structure of Human Carbonmonoxy-Haemoglobin at 1.25 A Resolution Deposited 2001-09-27 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.7；298 K；potassium phosphate, pH 6.7, SMALL TUBES, temperature 298K
Resolution 1.25 Å R-free 0.214
1J3Y Direct observation of photolysis-induced tertiary structural changes in human hemoglobin; Crystal structure of alpha(Fe)-beta(Ni) hemoglobin (laser photolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, SMALL TUBES, temperature 293K, pH 6.60
Resolution 1.55 Å R-free 0.205
1J3Y Direct observation of photolysis-induced tertiary structural changes in human hemoglobin; Crystal structure of alpha(Fe)-beta(Ni) hemoglobin (laser photolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 1–146（146 aa）
Chain H 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, SMALL TUBES, temperature 293K, pH 6.60
Resolution 1.55 Å R-free 0.205
1J3Z Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Fe-CO)-beta(Ni) hemoglobin (laser unphotolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, SMALL TUBES, temperature 293K, pH 6.60
Resolution 1.60 Å R-free 0.196
1J3Z Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Fe-CO)-beta(Ni) hemoglobin (laser unphotolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 1–146（146 aa）
Chain H 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, SMALL TUBES, temperature 293K, pH 6.60
Resolution 1.60 Å R-free 0.196
1J40 Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe-CO) hemoglobin (laser unphotolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, pH 6.6, SMALL TUBES, temperature 293K
Resolution 1.45 Å R-free 0.197
1J40 Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe-CO) hemoglobin (laser unphotolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 1–146（146 aa）
Chain H 1–146（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, pH 6.6, SMALL TUBES, temperature 293K
Resolution 1.45 Å R-free 0.197
1J41 Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe) hemoglobin (laser photolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, pH 6.6, SMALL TUBES, temperature 293K
Resolution 1.45 Å R-free 0.195
1J41 Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe) hemoglobin (laser photolysed) Deposited 2003-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 1–146（146 aa）
Chain H 1–146（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 3 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, pH 6.6, SMALL TUBES, temperature 293K
Resolution 1.45 Å R-free 0.195
1J7S Crystal Structure of deoxy HbalphaYQ, a mutant of HbA Deposited 2001-05-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa） Fragment：beta chain
Chain D 1–146（146 aa） Fragment：beta chain
Mutation：V1M Mutation：V1M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.7；293 K；Ammonium sulphate, ammonium phosphate, pH 6.7, SMALL TUBES, temperature 293K
Resolution 2.20 Å R-free 0.210
1J7W Crystal structure of deoxy HbbetaYQ, a site directed mutant of HbA Deposited 2001-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa） Fragment：beta chain
Chain D 1–146（146 aa） Fragment：beta chain
Mutation：V1M, I28Y, H63Q Mutation：V1M, I28Y, H63Q HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.7；298 K；ammonium sulphate, ammonium phosphate, pH 6.7, SMALL TUBES, temperature 298.0K
Resolution 2.00 Å R-free 0.223
1J7Y Crystal structure of partially ligated mutant of HbA Deposited 2001-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa） Fragment：beta chain
Chain D 1–146（146 aa） Fragment：beta chain
Mutation：V1M, L28Y, H63Q Mutation：V1M, L28Y, H63Q HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 CMO CARBON MONOXIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.7；298 K；ammonium sulphate, ammonium phosphate, pH 6.7, SMALL TUBES, temperature 298.0K
Resolution 1.70 Å R-free 0.201
1JY7 THE STRUCTURE OF HUMAN METHEMOGLOBIN. THE VARIATION OF A THEME Deposited 2001-09-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；293 K；PEG 4000, Sodium potassium phosphate, pH 6.7, LIQUID DIFFUSION at 293K
Resolution 3.20 Å R-free 0.245
1JY7 THE STRUCTURE OF HUMAN METHEMOGLOBIN. THE VARIATION OF A THEME Deposited 2001-09-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain Q 1–146（146 aa）
Chain S 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；293 K；PEG 4000, Sodium potassium phosphate, pH 6.7, LIQUID DIFFUSION at 293K
Resolution 3.20 Å R-free 0.245
1JY7 THE STRUCTURE OF HUMAN METHEMOGLOBIN. THE VARIATION OF A THEME Deposited 2001-09-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain V 1–146（146 aa）
Chain X 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；293 K；PEG 4000, Sodium potassium phosphate, pH 6.7, LIQUID DIFFUSION at 293K
Resolution 3.20 Å R-free 0.245
1K0Y X-ray Crystallographic Analyses of Symmetrical Allosteric Effectors of Hemoglobin. Compounds Designed to Link Primary and Secondary Binding Sites Deposited 2001-09-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 CNO 2-{4-[(3{2-[4-(1-CARBOXY-1-METHYL-ETHOXY)-PHENYL]-ACETYLAMINO}-PHENYLCARBAMOYL)-METHYL]-PHENOXY}-2-METHYL-PROPIONIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；Ammonium sulfate, ammonium phosphate, ferrous citrate, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 1.87 Å R-free 0.189
1K1K Structure of Mutant Human Carbonmonoxyhemoglobin C (beta E6K) at 2.0 Angstrom Resolution in Phosphate Buffer. Deposited 2001-09-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Mutation：E6K HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch method；pH 7.35；310 K；potassium phosphate 1.75M, pH 7.35, batch method, temperature 310K
Resolution 2.00 Å R-free 0.238
1KD2 Crystal Structure of Human Deoxyhemoglobin in Absence of Any Anions Deposited 2001-11-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH METHOD；pH 7；298 K；DEIONIZED PEG 3350 12.5%, pH 7.0, BATCH METHOD, temperature 298K
Resolution 1.87 Å R-free 0.250
1LFL DEOXY HEMOGLOBIN (90% RELATIVE HUMIDITY) Deposited 2002-04-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
Resolution 2.70 Å R-free 0.263
1LFL DEOXY HEMOGLOBIN (90% RELATIVE HUMIDITY) Deposited 2002-04-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain Q 1–146（146 aa）
Chain S 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
Resolution 2.70 Å R-free 0.263
1LFQ OXY HEMOGLOBIN (93% RELATIVE HUMIDITY) Deposited 2002-04-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
Resolution 2.60 Å R-free 0.258
1LFT OXY HEMOGLOBIN (90% RELATIVE HUMIDITY) Deposited 2002-04-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
Resolution 2.60 Å R-free 0.265
1LFV OXY HEMOGLOBIN (88% RELATIVE HUMIDITY) Deposited 2002-04-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
Resolution 2.80 Å R-free 0.270
1LFY OXY HEMOGLOBIN (84% RELATIVE HUMIDITY) Deposited 2002-04-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
Resolution 3.30 Å R-free 0.261
1LFZ OXY HEMOGLOBIN (25% METHANOL) Deposited 2002-04-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
Resolution 3.10 Å R-free 0.268
1LJW Crystal Structure of Human Carbonmonoxy Hemoglobin at 2.16 A: A Snapshot of the Allosteric Transition Deposited 2002-04-22 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.4；298 K；Potassium phosphate, Sodium phosphate, toluene, hemoglobin, pH 6.4, LIQUID DIFFUSION, temperature 298K
Resolution 2.16 Å R-free 0.259
1M9P Crystalline Human Carbonmonoxy Hemoglobin C Exhibits The R2 Quaternary State at Neutral pH In The Presence of Polyethylene Glycol: The 2.1 Angstrom Resolution Crystal Structure Deposited 2002-07-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.1；298 K；21% Polyethylene glycol, 0.150M HEPES-Na, chloride anion traces, pH 7.1, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.10 Å R-free 0.269
1MKO A Fourth Quaternary Structure of Human Hemoglobin A at 2.18 A Resolution Deposited 2002-08-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded PO4 PHOSPHATE ION × 3 CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.4；298 K；potassium and sodium phosphate, toluene, hemoglobin, pH 6.4, LIQUID DIFFUSION at 298K
Resolution 2.18 Å R-free 0.284
1NEJ Crystalline Human Carbonmonoxy Hemoglobin S (Liganded Sickle Cell Hemoglobin) Exhibits The R2 Quaternary State At Neutral pH In The Presence Of Polyethylene Glycol: The 2.1 Angstrom Resolution Crystal Structure Deposited 2002-12-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa） Fragment：beta chain
Chain D 1–146（146 aa） Fragment：beta chain
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.1；298 K；25% PEG 4000, 0.15M HEPES-Na,chloride anion traces; pH 7.1, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 298K
Resolution 2.10 Å R-free 0.268
1NIH Structure of deoxy-quaternary haemoglobin with liganded beta subunits Deposited 1990-03-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 IHP INOSITOL HEXAKISPHOSPHATE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å
1NQP Crystal structure of Human hemoglobin E at 1.73 A resolution Deposited 2003-01-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric
Chain not uniquely mapped Reference range not declared
Chain B 1–146（146 aa）
Not recorded CYN CYANIDE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；PEG and Glycerol, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 1.73 Å R-free 0.211
1O1I Cyanomet hemoglobin (A-GLY-C:V1M,L29F,H58Q; B,D:V1M,L106W) Deposited 2002-11-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Mutation：V1M, L106W CYN CYANIDE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；pH 6.70
Resolution 2.30 Å R-free 0.267
1O1J Deoxy hemoglobin (A-GLY-C:V1M,L29F,H58Q; B,D:V1M,L106W) Deposited 2002-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, L106W Mutation：V1M, L106W HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；pH 6.50
Resolution 1.90 Å R-free 0.229
1O1K Deoxy hemoglobin (A,C:V1M; B,D:V1M,V67W) Deposited 2002-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, V67W Mutation：V1M, V67W HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；pH 6.50
Resolution 2.00 Å R-free 0.249
1O1L Deoxy hemoglobin (A-GLY-C:V1M,L29W,H58Q; B,D:V1M) Deposited 2002-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M Mutation：V1M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；pH 6.50
Resolution 1.80 Å R-free 0.254
1O1M Deoxy hemoglobin (A-GLYGLYGLY-C:V1M,L29F,H58Q B,D:V1M,V67W) Deposited 2002-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, V67W Mutation：V1M, V67W HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；pH 6.50
Resolution 1.85 Å R-free 0.250
1O1N Deoxy hemoglobin (A-GLYGLYGLY-C:V1M,L29W; B,D:V1M) Deposited 2002-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；pH 6.50
Resolution 1.80 Å R-free 0.242
1O1O Deoxy hemoglobin (A,C:V1M,V62L; B,D:V1M,V67L) Deposited 2002-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, V67L Mutation：V1M, V67L HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；pH 6.50
Resolution 1.80 Å R-free 0.222
1O1P Deoxy hemoglobin (A-GLY-C:V1M; B,D:V1M,C93A,N108K) Deposited 2002-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, C93A, N108K Mutation：V1M, C93A, N108K HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；pH 6.50
Resolution 1.80 Å R-free 0.245
1QI8 DEOXYGENATED STRUCTURE OF A DISTAL POCKET HEMOGLOBIN MUTANT Deposited 1999-06-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa） Fragment：BETA CHAIN
Chain D 1–146（146 aa） Fragment：BETA CHAIN
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；HIGH SALT (PERUTZ, 1968)., pH 6.5
Resolution 1.80 Å R-free 0.222
1QSH MAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME Deposited 1999-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 HEG PROTOPORPHYRIN IX CONTAINING MG × 2 X-RAY DIFFRACTION
X-ray crystallization conditions Batch Method；pH 6.5；298 K；Ammonium sulfate , pH 6.5, Batch Method, temperature 298K
Resolution 1.70 Å
1QSI MAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME Deposited 1999-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HEG PROTOPORPHYRIN IX CONTAINING MG × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH METHOD；pH 6.5；298 K；AMMONIUM SULFATE, pH 6.5, BATCH METHOD, temperature 298K
Resolution 1.70 Å
1QXD Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds Deposited 2003-09-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa） Fragment：beta chain
Chain D 1–146（146 aa） Fragment：beta chain
Not recorded SO4 SULFATE ION × 7 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FU2 FURFURAL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；ammonium phosphate and sulfate, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 2.25 Å R-free 0.274
1QXD Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds Deposited 2003-09-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–146（146 aa） Fragment：beta chain
Chain D 1–146（146 aa） Fragment：beta chain
Not recorded SO4 SULFATE ION × 14 HEM PROTOPORPHYRIN IX CONTAINING FE × 8 FU2 FURFURAL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；ammonium phosphate and sulfate, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 2.25 Å R-free 0.274
1QXE Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds Deposited 2003-09-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa） Fragment：beta chain
Chain D 1–146（146 aa） Fragment：beta chain
Not recorded SO4 SULFATE ION × 7 OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FUX 5-HYDROXYMETHYL-FURFURAL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；ammonium phosphate and sulfate, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 1.85 Å R-free 0.223
1QXE Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds Deposited 2003-09-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–146（146 aa） Fragment：beta chain
Chain D 1–146（146 aa） Fragment：beta chain
Not recorded SO4 SULFATE ION × 14 OXY OXYGEN MOLECULE × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 8 FUX 5-HYDROXYMETHYL-FURFURAL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；ammonium phosphate and sulfate, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 1.85 Å R-free 0.223
1QXE Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds Deposited 2003-09-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–146（146 aa） Fragment：beta chain
Chain D 1–146（146 aa） Fragment：beta chain
Not recorded SO4 SULFATE ION × 14 OXY OXYGEN MOLECULE × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 8 FUX 5-HYDROXYMETHYL-FURFURAL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；ammonium phosphate and sulfate, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 1.85 Å R-free 0.223
1R1X Crystal structure of oxy-human hemoglobin Bassett at 2.15 angstrom Deposited 2003-09-25 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；potassium/Sodium phosphate, toluene, hemoglobin, pH 6.7, LIQUID DIFFUSION, temperature 298K
Resolution 2.15 Å R-free 0.288
1R1Y Crystal structure of deoxy-human hemoglobin Bassett at 1.8 angstrom Deposited 2003-09-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；Ammonium phosphate/sulfate, iron citrate, sodium dithionite, deoxyhemoglobin, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 1.80 Å R-free 0.236
1RPS Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin. Hemoglobin exposed to NO under anerobic conditions Deposited 2003-12-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NO NITRIC OXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10 mg/mL human hemoglobin, 10 mM potassium phosphate, 100 mM potassium chloride, 10-12% PEG 6000, 3 mM sodium dithionite (under anaerobic conditions), BATCH METHOD, temperature 298K, pH 7
Resolution 2.11 Å R-free 0.232
1RQ3 Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Deoxyhemoglobin, Deoxyhemoglobin Deposited 2003-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；pH 7.0
Resolution 1.91 Å R-free 0.198
1RQ4 Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin, HEMOGLOBIN EXPOSED TO NO UNDER AEROBIC CONDITIONS Deposited 2003-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NO NITRIC OXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；pH 7.0
Resolution 2.11 Å R-free 0.241
1RQA Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin. Beta W73E hemoglobin exposed to NO under anaerobic conditions Deposited 2003-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：W37E, V1M Mutation：W37E, V1M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NO NITRIC OXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10 mg/mL human hemoglobin, 10 mM potassium phosphate, 100 mM potassium chloride, 10-12% PEG 6000, 3mM sodium dithionite (under anaerobic conditions), pH 7.0, BATCH METHOD, temperature 298K
Resolution 2.11 Å R-free 0.231
1RVW R STATE HUMAN HEMOGLOBIN [ALPHA V96W], CARBONMONOXY Deposited 1997-03-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Mutation：CHAIN A, V96W PO4 PHOSPHATE ION × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å
1SDK CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A Deposited 1996-02-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 TMM 1,3,5-BENZENETRICARBOXYLIC ACID × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1SDK CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A Deposited 1996-02-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 8 CMO CARBON MONOXIDE × 8 TMM 1,3,5-BENZENETRICARBOXYLIC ACID × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1SDL CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A Deposited 1996-02-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 TMM 1,3,5-BENZENETRICARBOXYLIC ACID × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1SDL CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A Deposited 1996-02-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 8 CMO CARBON MONOXIDE × 8 TMM 1,3,5-BENZENETRICARBOXYLIC ACID × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1THB REFINEMENT OF A PARTIALLY OXYGENATED T STATE HAEMOGLOBIN AT 1.5 ANGSTROMS RESOLUTION Deposited 1990-01-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 IHP INOSITOL HEXAKISPHOSPHATE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
1UIW Crystal Structures of Unliganded and Half-Liganded Human Hemoglobin Derivatives Cross-Linked between Lys 82beta1 and Lys 82beta2 Deposited 2003-07-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.6；293 K；PEG6000, pH 6.60, SMALL TUBES, temperature 293K
Resolution 1.50 Å R-free 0.205
1UIW Crystal Structures of Unliganded and Half-Liganded Human Hemoglobin Derivatives Cross-Linked between Lys 82beta1 and Lys 82beta2 Deposited 2003-07-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 1–146（146 aa）
Chain H 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.6；293 K；PEG6000, pH 6.60, SMALL TUBES, temperature 293K
Resolution 1.50 Å R-free 0.205
1VWT T STATE HUMAN HEMOGLOBIN [ALPHA V96W], ALPHA AQUOMET, BETA DEOXY Deposited 1997-03-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：CHAIN A, C, V96W Mutation：CHAIN A, C, V96W HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å
1XXT The T-to-T High Transitions in Human Hemoglobin: wild-type deoxy Hb A (low salt, one test set) Deposited 2004-11-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml hemoglobin, pH 7.0, BATCH, temperature 298K
Resolution 1.91 Å R-free 0.239
1XY0 T-to-THigh Transitions in Human Hemoglobin: alphaK40G deoxy low-salt Deposited 2004-11-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.99 Å R-free 0.260
1XYE T-to-THigh Transitions in Human Hemoglobin: alpha Y42A deoxy low salt Deposited 2004-11-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.13 Å R-free 0.241
1XZ2 wild-type hemoglobin deoxy no-salt Deposited 2004-11-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；12% PEG 1450, 10 mg/ml Hb, pH 7.0, batch, temperature 298.0K
Resolution 1.90 Å R-free 0.201
1XZ4 Intersubunit Interactions Associated with Tyr42alpha Stabilize the Quaternary-T Tetramer but are not Major Quaternary Constraints in Deoxyhemoglobin: alphaY42A deoxyhemoglobin no-salt Deposited 2004-11-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 4.6；298 K；15% PEG 4000, 50 mM sodium acetate, 100 mM ammonium acetate, 3 mM sodium dithionite, 20 mg/ml Hb, pH 4.6, batch, temperature 298K
Resolution 2.00 Å R-free 0.224
1XZ5 T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaL91A deoxy low-salt Deposited 2004-11-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM ammonium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.11 Å R-free 0.248
1XZ7 T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaR92A deoxy low-salt Deposited 2004-11-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.90 Å R-free 0.203
1XZU T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaD94G deoxy low-salt Deposited 2004-11-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM ammonium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature , temperature 298K
Resolution 2.16 Å R-free 0.260
1XZV T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaP95A deoxy low-salt Deposited 2004-11-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.11 Å R-free 0.246
1Y09 T-to-T(High) Quaternary Transitions in Human Hemoglobin: alphaN97A deoxy low-salt Deposited 2004-11-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.25 Å R-free 0.206
1Y0A T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaY140A deoxy low-salt Deposited 2004-11-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.22 Å R-free 0.237
1Y0C T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaY140F deoxy low-salt Deposited 2004-11-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.30 Å R-free 0.256
1Y0D T-to-THigh Quaternary Transitions in Human Hemoglobin: desArg141alpha deoxy low-salt Deposited 2004-11-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.10 Å R-free 0.242
1Y0T T-to-T(High) Quaternary Transitions in Human Hemoglobin: betaV1M deoxy low-salt (1 test set) Deposited 2004-11-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M Mutation：V1M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.14 Å R-free 0.238
1Y0W T-to-THigh quaternary Transitions in Human Hemoglobin: betaV1M deoxy low-salt (10 test sets) Deposited 2004-11-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M Mutation：V1M HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.14 Å R-free 0.192
1Y22 T-To-T(High) quaternary transitions in human hemoglobin: betaV33A deoxy low-salt (1 test set) Deposited 2004-11-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, V33A Mutation：V1M, V33A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 mM POTASSIUM PHOSPHATE, 100 mM POTASSIUM CHLORIDE, 3 mM SODIUM DITHIONITE, 10 mg/ml Hb, pH 7.00, temperature 298K
Resolution 2.16 Å R-free 0.248
1Y2Z T-To-T(High) quaternary transitions in human hemoglobin: betaV34G deoxy low-salt (1 test set) Deposited 2004-11-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, V34G Mutation：V1M, V34G HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298.0K
Resolution 2.07 Å R-free 0.240
1Y31 T-To-T(High) quaternary transitions in human hemoglobin: betaY35A deoxy low-salt (1 test set) Deposited 2004-11-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, Y35A Mutation：V1M, Y35A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298.0K
Resolution 2.13 Å R-free 0.251
1Y35 T-To-T(High) quaternary transitions in human hemoglobin: betaY35F deoxy low-salt (1 test set) Deposited 2004-11-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, Y35F Mutation：V1M, Y35F HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.12 Å R-free 0.244
1Y45 T-To-T(high) quaternary transitions in human hemoglobin: betaP36A deoxy low-salt (10 test sets) Deposited 2004-11-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, P36A Mutation：V1M, P36A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.00 Å R-free 0.209
1Y46 T-To-T(High) quaternary transitions in human hemoglobin: betaW37Y deoxy low-salt (10 test sets) Deposited 2004-11-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, W37Y Mutation：V1M, W37Y HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.22 Å R-free 0.243
1Y4B T-To-T(High) quaternary transitions in human hemoglobin: betaW37H deoxy low-salt (10 test sets) Deposited 2004-11-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, W37H Mutation：V1M, W37H HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.10 Å R-free 0.238
1Y4F T-To-T(High) quaternary transitions in human hemoglobin: betaW37A deoxy low-salt (10 test sets) Deposited 2004-11-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, W37A Mutation：V1M, W37A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.00 Å R-free 0.216
1Y4G T-To-T(High) quaternary transitions in human hemoglobin: betaW37G deoxy low-salt (10 test sets) Deposited 2004-11-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, W37G Mutation：V1M, W37G HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.91 Å R-free 0.235
1Y4P T-To-T(high) quaternary transitions in human hemoglobin: betaW37E deoxy low-salt (10 test sets) Deposited 2004-12-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, W37E Mutation：V1M, W37E HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.98 Å R-free 0.231
1Y4Q T-To-T(High) quaternary transitions in human hemoglobin: betaF42A deoxy low-salt (1 test set) Deposited 2004-12-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, F42A Mutation：V1M, F42A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.11 Å R-free 0.245
1Y4R T-To-T(High) quaternary transitions in human hemoglobin: betaF45A deoxy low-salt (1 test set) Deposited 2004-12-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, F45A Mutation：V1M, F45A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.22 Å R-free 0.246
1Y4V T-To-T(High) quaternary transitions in human hemoglobin: betaC93A deoxy low-salt (1 test set) Deposited 2004-12-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, C93A Mutation：V1M, C93A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.84 Å R-free 0.230
1Y5F T-To-T(High) quaternary transitions in human hemoglobin: betaL96A deoxy low-salt (1 test set) Deposited 2004-12-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, L96A Mutation：V1M, L96A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.14 Å R-free 0.243
1Y5J T-To-T(High) quaternary transitions in human hemoglobin: betaH97A deoxy low-salt (1 test set) Deposited 2004-12-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, H97A Mutation：V1M, H97A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.03 Å R-free 0.245
1Y5K T-To-T(High) quaternary transitions in human hemoglobin: betaD99A deoxy low-salt (10 test sets) Deposited 2004-12-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, D99A Mutation：V1M, D99A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.20 Å R-free 0.227
1Y7C T-To-T(High) quaternary transitions in human hemoglobin: betaP100A deoxy low-salt (1 test set) Deposited 2004-12-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, P100A Mutation：V1M, P100A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.10 Å R-free 0.284
1Y7D T-To-T(High) quaternary transitions in human hemoglobin: betaP100G deoxy low-salt (1 test set) Deposited 2004-12-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, P100G Mutation：V1M, P100G HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.90 Å R-free 0.252
1Y7G T-To-T(high) quaternary transitions in human hemoglobin: betaN102A deoxy low-salt (1 test set) Deposited 2004-12-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, N102A Mutation：V1M, N102A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 2.10 Å R-free 0.264
1Y7Z T-To-T(High) quaternary transitions in human hemoglobin: betaN108A deoxy low-salt (1 test set) Deposited 2004-12-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, N108A Mutation：V1M, N108A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.98 Å R-free 0.233
1Y83 T-To-T(High) quaternary transitions in human hemoglobin: betaY145G deoxy low-salt (1 test set) Deposited 2004-12-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, Y145G Mutation：V1M, Y145G HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
Resolution 1.90 Å R-free 0.248
1Y85 T-To-T(High) quaternary transitions in human hemoglobin: desHIS146beta deoxy low-salt Deposited 2004-12-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–145（145 aa） Fragment：RESIDUES 1-145
Chain D 1–145（145 aa） Fragment：RESIDUES 1-145
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.00, batch, temperature 298.0K
Resolution 2.13 Å R-free 0.237
1Y8W T-To-T(High) quaternary transitions in human hemoglobin: alphaR92A oxy (2mM IHP, 20% PEG) (10 test sets) Deposited 2004-12-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 2.90 Å R-free 0.267
1YDZ T-To-T(High) quaternary transitions in human hemoglobin: alphaY140F oxy (2MM IHP, 20% PEG) (1 test set) Deposited 2004-12-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 3.30 Å R-free 0.307
1YE0 T-To-T(High) quaternary transitions in human hemoglobin: betaV33A oxy (2MM IHP, 20% PEG) (1 test set) Deposited 2004-12-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, V33A Mutation：V1M, V33A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 2.50 Å R-free 0.264
1YE1 T-To-T(High) quaternary transitions in human hemoglobin: betaY35A oxy (2MM IHP, 20% PEG) (1 test set) Deposited 2004-12-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, Y35A Mutation：V1M, Y35A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 4.50 Å R-free 0.343
1YE2 T-To-T(High) quaternary transitions in human hemoglobin: betaY35F oxy (2MM IHP, 20% PEG) (1 test set) Deposited 2004-12-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, Y35F Mutation：V1M, Y35F HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 1.80 Å R-free 0.212
1YEN T-To-T(High) quaternary transitions in human hemoglobin: betaP36A oxy (2MM IHP, 20% PEG) (10 test sets) Deposited 2004-12-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, P36A Mutation：V1M, P36A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 2.80 Å R-free 0.267
1YEO T-To-T(High) quaternary transitions in human hemoglobin: betaW37A OXY (10 test sets) Deposited 2004-12-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, W37A Mutation：V1M, W37A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 13% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE. THE CRYSTAL WAS THEN EXPOSED TO AIR AT 298K AND DATA WAS COLLECTED AT 298K.
Resolution 2.22 Å R-free 0.228
1YEQ T-To-T(High) quaternary transitions in human hemoglobin: betaW37Y OXY (10 test sets) Deposited 2004-12-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, W37Y Mutation：V1M, W37Y HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 13% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE. THE CRYSTAL WAS THEN EXPOSED TO AIR AT 298K AND DATA WAS COLLECTED AT 298K.
Resolution 2.75 Å R-free 0.274
1YEU T-To-T(High) quaternary transitions in human hemoglobin: betaW37G OXY (10 test sets) Deposited 2004-12-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, W37G Mutation：V1M, W37G HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 13% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE. THE CRYSTAL WAS THEN EXPOSED TO AIR AT 298K AND DATA WAS COLLECTED AT 298K.
Resolution 2.12 Å R-free 0.254
1YEV T-To-T(High) quaternary transitions in human hemoglobin: betaW37E OXY (10 test sets) Deposited 2004-12-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, W37E Mutation：V1M, W37E HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 13% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE. THE CRYSTAL WAS THEN EXPOSED TO AIR AT 298K AND DATA WAS COLLECTED AT 298K.
Resolution 2.11 Å R-free 0.242
1YFF STRUCTURE OF HUMAN CARBONMONOXYHEMOGLOBIN C (BETA E6K): TWO QUATERNARY STATES (R2 and R3) IN ONE CRYSTAL Deposited 2004-12-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：E6K Mutation：E6K HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；PEG 4000, SODIUM PHOSPHATE, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.40 Å R-free 0.250
1YFF STRUCTURE OF HUMAN CARBONMONOXYHEMOGLOBIN C (BETA E6K): TWO QUATERNARY STATES (R2 and R3) IN ONE CRYSTAL Deposited 2004-12-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 1–146（146 aa）
Chain H 1–146（146 aa）
Mutation：E6K Mutation：E6K HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；PEG 4000, SODIUM PHOSPHATE, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.40 Å R-free 0.250
1YG5 T-To-T(High) quaternary transitions in human hemoglobin: betaW37H OXY (2MM IHP, 20% PEG) (10 test sets) Deposited 2005-01-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, W37H Mutation：V1M, W37H HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 2.70 Å R-free 0.273
1YGD T-To-T(High) quaternary transitions in human hemoglobin: betaW37E alpha zinc beta oxy (10 TEST SETS) Deposited 2005-01-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, W37E Mutation：V1M, W37E ZNH PROTOPORPHYRIN IX CONTAINING ZN × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 13% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE. THE CRYSTAL WAS THEN EXPOSED TO AIR AT 298K AND DATA WAS COLLECTED AT 298K.
Resolution 2.73 Å R-free 0.266
1YGF T-to-T(high) quaternary transitions in human hemoglobin: betaH97A oxy (2MM IHP, 20% PEG) (1 test set) Deposited 2005-01-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, H97A Mutation：V1M, H97A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 2.70 Å R-free 0.270
1YH9 T-to-T(High) quaternary transitions in human hemoglobin: HbA OXY (2MM IHP, 20% PEG) (10 test sets) Deposited 2005-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 2.20 Å R-free 0.236
1YHE T-To-T(High) quaternary transitions in human hemoglobin: HbA OXY (5.0MM IHP, 20% PEG) (10 test sets) Deposited 2005-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 5.0 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
Resolution 2.10 Å R-free 0.208
1YHR T-To-T(High) quaternary transitions in human hemoglobin: HbA OXY (10.0MM IHP, 20% PEG) (10 test sets) Deposited 2005-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, 1 ATM N2, pH 7.0, batch, temperature 298.0K
Resolution 2.60 Å R-free 0.270
1YIE T-to-thigh quaternary transitions in human hemoglobin: betaW37A oxy (2.2MM IHP, 13% PEG) (1 test set) Deposited 2005-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, W37A Mutation：V1M, W37A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, 1 ATM N2, pH 7.00, batch, temperature 298.0K
Resolution 2.40 Å R-free 0.273
1YIH T-to-T(High) quaternary transitions in human hemoglobin: betaP100A oxy (2.2MM IHP, 20% PEG) (1 test set) Deposited 2005-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：V1M, P100A Mutation：V1M, P100A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 7；298 K；10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, 1 ATM N2, pH 7.0, batch, temperature 298.0K
Resolution 2.00 Å R-free 0.247
1YVQ The low salt (PEG) crystal structure of CO Hemoglobin E (betaE26K) approaching physiological pH (pH 7.5) Deposited 2005-02-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：E26K Mutation：E26K HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；290 K；0.1M HEPES, pH 7.5; 10% isopropanol, 20% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 290K
Resolution 1.80 Å R-free 0.230
1YVT The high salt (phosphate) crystal structure of CO Hemoglobin E (Glu26Lys) at physiological pH (pH 7.35) Deposited 2005-02-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Mutation：E26K HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.35；289 K；1.65M potassium phosphate, 0.1M HEPES, ph 7.35, Batch Method, temperature 289K
Resolution 1.80 Å R-free 0.236
1YZI A novel quaternary structure of human carbonmonoxy hemoglobin Deposited 2005-02-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 6 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 7.1；298 K；sodium/potassium phosphate, toluene, pH 7.1, SMALL TUBES, temperature 298K
Resolution 2.07 Å R-free 0.257
28OD Crystal structure of C35 bound to Hem Deposited 2026-02-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 4 A1ITR 4-[2-[[5-(1H-indol-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanoylamino]benzoic acid × 2 DMS DIMETHYL SULFOXIDE × 10 CMO CARBON MONOXIDE × 4 ACT ACETATE ION × 3 SO4 SULFATE ION × 20 PGE TRIETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；3.0 M Ammonium sulfate; 1% (wv) MPD
Resolution 1.73 Å R-free 0.200
2D5Z Crystal structure of T-state human hemoglobin complexed with three L35 molecules Deposited 2005-11-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 L35 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID × 3 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 5.8；293 K；18% PEG 6000, 100mM Na-Cacodylate, 0.1mM L35, pH 5.8, BATCH, temperature 293K
Resolution 1.45 Å R-free 0.215
2D60 Crystal structure of deoxy human hemoglobin complexed with two L35 molecules Deposited 2005-11-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 L35 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.5；293 K；2.5M Ammonium sulfate, Ammonium phosphate, 0.1mM L35, pH 6.5, BATCH, temperature 293K
Resolution 1.70 Å R-free 0.240
2DN1 1.25A resolution crystal structure of human hemoglobin in the oxy form Deposited 2006-04-25 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 MBN TOLUENE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 6.7；277 K；sodium/potassium phosphate, glycerol, pH 6.7, Batch, temperature 277K
Resolution 1.25 Å
2DN2 1.25A resolution crystal structure of human hemoglobin in the deoxy form Deposited 2006-04-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 6.5；293 K；Ammonium sulfate, Ammonium phosphate, pH 6.5, Batch, temperature 293K
Resolution 1.25 Å
2DN3 1.25A resolution crystal structure of human hemoglobin in the carbonmonoxy form Deposited 2006-04-25 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.7；293 K；sodium/potassium phosphate, glycerol, pH 6.7, BATCH, temperature 293K
Resolution 1.25 Å
2DXM Neutron Structure Analysis of Deoxy Human Hemoglobin Deposited 2006-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NEUTRON DIFFRACTION
X-ray crystallization conditions MICRODIALYSIS；D2O, MICRODIALYSIS
Resolution 2.10 Å R-free 0.260
2H35 Solution structure of Human normal adult hemoglobin Deposited 2006-05-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SOLUTION NMR
NMR measurement conditions pH 7；303 K；Ionic strength (raw mmCIF value) 100 mM；Pressure 1
NMR sample composition alpha_subunit 1.0mM, Na phosphate 0.1M, 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR sample composition beta_subunit 1.0mM, Na phosphate 0.1M, 90% H2O, 10% D2O | 90% H2O/10% D2O
Resolution not provided
2HBC HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES Deposited 1994-08-31 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ENC ETHYL ISOCYANIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å
2HBD HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES Deposited 1994-08-31 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MNC METHYL ISOCYANIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å
2HBE HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES Deposited 1994-08-31 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NBN N-BUTYL ISOCYANIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å
2HBF HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES Deposited 1994-08-31 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NPN N-PROPYL ISOCYANIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å
2HBS THE HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S Deposited 1997-05-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：E6V VARIANT Mutation：E6V VARIANT HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 4；HBS WAS SUSPENDED IN 30 MM PHOSPHATE BUFFER, PH 7.0, DEOXYGENATED AND CONCENTRATED TO 120 MG/ML. PROTEIN WAS CRYSTALLIZED IN AN ANAEROBIC CHAMBER IN TUBE CONTAINING 10 UL PROTEIN SOLUTION, 5 UL CITRATE BUFFER (PH 4.0), AND 4UL OF 33% PEG 8K, crystallized in anaerobic chamber
Resolution 2.05 Å R-free 0.215
2HBS THE HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S Deposited 1997-05-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 1–146（146 aa）
Chain H 1–146（146 aa）
Mutation：E6V VARIANT Mutation：E6V VARIANT HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 4；HBS WAS SUSPENDED IN 30 MM PHOSPHATE BUFFER, PH 7.0, DEOXYGENATED AND CONCENTRATED TO 120 MG/ML. PROTEIN WAS CRYSTALLIZED IN AN ANAEROBIC CHAMBER IN TUBE CONTAINING 10 UL PROTEIN SOLUTION, 5 UL CITRATE BUFFER (PH 4.0), AND 4UL OF 33% PEG 8K, crystallized in anaerobic chamber
Resolution 2.05 Å R-free 0.215
2HCO THE STRUCTURE OF HUMAN CARBONMONOXY HAEMOGLOBIN AT 2.7 ANGSTROMS RESOLUTION Deposited 1979-08-07 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å
2HHD OXYGEN AFFINITY MODULATION BY THE N-TERMINI OF THE BETA-CHAINS IN HUMAN AND BOVINE HEMOGLOBIN Deposited 1994-09-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å
2HHE OXYGEN AFFINITY MODULATION BY THE N-TERMINI OF THE BETA CHAINS IN HUMAN AND BOVINE HEMOGLOBIN Deposited 1994-09-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 3–146（144 aa）
Chain D 3–146（144 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å
2M6Z Refined solution structure of Human Adult Hemoglobin in the Carbonmonoxy Form Deposited 2013-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SOLUTION NMR
NMR measurement conditions pH 7；308 K
NMR sample composition 1.2 mM [U-13C; U-15N] HbCO A-1, 1.0 mM [U-13C; U-15N] HbCO A-2, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
2W6V Structure of Human deoxy Hemoglobin A in complex with Xenon Deposited 2008-12-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa） Fragment：CHAIN BETA, RESIDUES 2-147
Chain D 2–147（146 aa） Fragment：CHAIN BETA, RESIDUES 2-147
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 3 SO4 SULFATE ION × 5 XE XENON × 10 PO4 PHOSPHATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；3.2M (NH4)2SO4, 0.1M (NH4)H2PO4, 0.3M (NH4)2HPO4, PH 6.5, 0.2% DITHIONITE.
Resolution 1.80 Å R-free 0.216
2W72 DEOXYGENATED STRUCTURE OF A DISTAL SITE HEMOGLOBIN MUTANT PLUS XE Deposited 2008-12-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa） Fragment：CHAIN BETA, RESIDUES 2-147
Chain D 2–147（146 aa） Fragment：CHAIN BETA, RESIDUES 2-147
Mutation：YES Mutation：YES HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 8 XE XENON × 15 K POTASSIUM ION × 3 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；3.2M AMMONIUM SULPHATE 0.1M AMMONIUM PHOSPHATE 0.3M K PHOSPHATE PH 6.7
Resolution 1.07 Å R-free 0.153
2YRS Human hemoglobin D Los Angeles: crystal structure Deposited 2007-04-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.6；293 K；pH 7.6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.30 Å R-free 0.252
2YRS Human hemoglobin D Los Angeles: crystal structure Deposited 2007-04-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain K 2–147（146 aa）
Chain O 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.6；293 K；pH 7.6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.30 Å R-free 0.252
3B75 Crystal Structure of Glycated Human Haemoglobin Deposited 2007-10-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded FRU beta-D-fructofuranose × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 GLC alpha-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.7；277 K；PEG 4000, pH 6.7, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.30 Å R-free 0.331
3B75 Crystal Structure of Glycated Human Haemoglobin Deposited 2007-10-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Chain H 2–147（146 aa）
Not recorded FRU beta-D-fructofuranose × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.7；277 K；PEG 4000, pH 6.7, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.30 Å R-free 0.331
3B75 Crystal Structure of Glycated Human Haemoglobin Deposited 2007-10-30 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain T 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 GLC alpha-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.7；277 K；PEG 4000, pH 6.7, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.30 Å R-free 0.331
3D17 A triply ligated crystal structure of relaxed state human hemoglobin Deposited 2008-05-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 1 CMO CARBON MONOXIDE × 3 PO4 PHOSPHATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.4；298 K；NaPhosph, KPhosph, Toluene, pH 6.4, liquid diffusion, temperature 298K
Resolution 2.80 Å R-free 0.297
3D7O Human hemoglobin, nitrogen dioxide anion modified Deposited 2008-05-21 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded NO2 NITRITE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；295 K；Sodium phosphate, Potassium phosphate, Toluene, Hemoglobin, pH 6.8, LIQUID DIFFUSION, temperature 295K
Resolution 1.80 Å R-free 0.237
3DUT The high salt (phosphate) crystal structure of deoxy hemoglobin E (GLU26LYS) at physiological pH (pH 7.35) Deposited 2008-07-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.35；294 K；1.65 M potassium phosphate, 0.05 M Bis-Tris, pH 7.35, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.55 Å R-free 0.277
3HXN The structure of human carbonmonoxyhemoglobin complex to IHP at 2.0 angstrons resolution. Deposited 2009-06-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 IHP INOSITOL HEXAKISPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；295 K；CARBONMONOXYHEMOGLOBIN:IHP 1:1, CRYSTALLIZED IN 27% PEG 3350 BUBBLED IN CO- , pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.00 Å R-free 0.283
3IC0 Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-298 Deposited 2009-07-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Not recorded OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 B77 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；3.2 - 3.6 M Sulfate/phosphate precipitant, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 1.80 Å R-free 0.230
3IC2 Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-266 Deposited 2009-07-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 B78 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；3.2 - 3.6 M Sulfate/phosphate precipitant, pH 6.5, LIQUID DIFFUSION, temperature 298K
Resolution 2.40 Å R-free 0.246
3KMF Room Temperature Time-of-Flight Neutron Diffraction Study of Deoxy Human Normal Adult Hemoglobin Deposited 2009-11-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 2–147（146 aa）
Chain G 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NEUTRON DIFFRACTION
X-ray crystallization conditions batch；pH 6.7；293 K；D2O, BATCH, ammonium sulfate, pH 6.7, batch, temperature 293K
Resolution 2.00 Å R-free 0.300
3NL7 Human Hemoglobin A mutant beta H63W carbonmonoxy-form Deposited 2010-06-21 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Mutation：H63W HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.7；293 K；Protein Solution (20mg/ml protein in 0.01 M phosphate pH 7.0) mixed with mother liquor (3.4 M Na/K phosphate, pH6.7) for final concentrations of 2.3 M Na/K phosphate, SMALL TUBES, temperature 293K
Resolution 1.80 Å R-free 0.233
3NMM Human Hemoglobin A mutant alpha H58W deoxy-form Deposited 2010-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions Batch Method；pH 6.5；293 K；20 ul Protein Solution (60mg/ml protein in 0.01 M ammonium phosphate pH 7.0) mixed with 100 ul mother liquor (0.5 ml 2M monobasic ammonium phosphate + 1.5 ml 2 M dibasic ammonium phosphate + 8 ml 4 M ammonium sulfate) for final concentrations of 2.4-2.6 M Ammonium phosphate/sulfate, Batch Method, temperature 293K
Resolution 1.60 Å R-free 0.198
3ODQ Structure of a Crystal Form of Human Methemoglobin Indicative of Fiber Formation Deposited 2010-08-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；295 K；15-30% PEG, pH 4.5-5.5, 0.2 M salt of several varieties, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.325
3ONZ Human tetrameric hemoglobin: proximal nitrite ligand at beta Deposited 2010-08-30 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa） Fragment：Hemoglobin Chain B
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NO2 NITRITE ION × 4 MBN TOLUENE × 8 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 7.1；295 K；sodium phospahte, potassium phosphate, toluene, nitrite, hemoglobin, pH 7.1, LIQUID DIFFUSION, temperature 295K
Resolution 2.09 Å R-free 0.280
3OO4 R-state human hemoglobin: nitriheme modified at alpha Deposited 2010-08-30 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded NTE [3,3'-{7-ethenyl-3,8,13,17-tetramethyl-12-[(E)-2-nitroethenyl]porphyrin-2,18-diyl-kappa~4~N~21~,N~22~,N~23~,N~24~}dipro panoato(2-)]iron × 2 NO2 NITRITE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；295 K；sodium phosphate, potassium phosphate, nitrite, toluene, hemoglobin, pH 6.8, LIQUID DIFFUSION, temperature 295K
Resolution 1.90 Å R-free 0.263
3OO5 R-state human hemoglobin: nitriheme modified Deposited 2010-08-30 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded NTE [3,3'-{7-ethenyl-3,8,13,17-tetramethyl-12-[(E)-2-nitroethenyl]porphyrin-2,18-diyl-kappa~4~N~21~,N~22~,N~23~,N~24~}dipro panoato(2-)]iron × 4 NO2 NITRITE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；295 K；sodium phosphate, potassium phosphate, nitrite, toluene, human hemoglobin, LIQUID DIFFUSION, temperature 295K
Resolution 2.10 Å R-free 0.287
3P5Q Ferric R-state human aquomethemoglobin Deposited 2010-10-10 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 6 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；295 K；sodium phosphate, potassium phosphate, toluene, hemoglobin, pH 6.8, LIQUID DIFFUSION, temperature 295K
Resolution 2.00 Å R-free 0.267
3QJB Human Hemoglobin A Mutant Alpha H58L Carbonmonoxy-Form Deposited 2011-01-28 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.7；293 K；2.3 M Na/K phosphate, pH 6.7, SMALL TUBES, temperature 293K
Resolution 1.80 Å R-free 0.205
3QJC Human Hemoglobin A Mutant Beta H63L Carbonmonoxy-Form Deposited 2011-01-28 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Mutation：H63L HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.7；293 K；2.3 M Na/K phosphate, pH 6.7, SMALL TUBES, temperature 293K
Resolution 2.00 Å R-free 0.250
3QJD Human Hemoglobin A Mutant Alpha H58L Deoxy-Form Deposited 2011-01-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.5；293 K；2.4-2.6 M ammonium phosphate/sulfate, pH 6.5, SMALL TUBES, temperature 293K
Resolution 1.56 Å R-free 0.191
3QJE Human Hemoglobin A Mutant Beta H63L Deoxy-Form Deposited 2011-01-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Mutation：H63L Mutation：H63L HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 6.5；293 K；2.4-2.6 M ammonium phosphate/sulfate, pH 6.5, SMALL TUBES, temperature 293K
Resolution 1.80 Å R-free 0.243
3R5I Crystal structure of liganded Hemoglobin complexed with a potent Antisickling agent, INN-312 Deposited 2011-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 3R5 5-methoxy-2-(pyridin-3-ylmethoxy)benzaldehyde × 3 SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.4；298 K；3.2 M Na+/K+ phosphate, pH 6.4, LIQUID DIFFUSION, temperature 298K
Resolution 2.20 Å R-free 0.268
3S65 Structures and oxygen affinities of crystalline human hemoglobin C (beta6 Lys) in the R2 quaternary structures Deposited 2011-05-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Mutation：E6K Mutation：E6K HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.6；293 K；11% (w/v) polyethylene glycol 3350, 50mM HEPES buffer, 10% (v/v) glycerol, pH 7.6, Batch, temperature 293K
Resolution 1.80 Å R-free 0.305
3S66 Structures and oxygen affinities of crystalline human hemoglobin C (beta6 Lys) in the R quaternary structures Deposited 2011-05-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Mutation：E6K HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；293 K；1.65M phosphate buffer (0.528M NaH2PO4, 1.122M K2HPO4, pH 7.2), 10% (v/v) glycerol, 0.1% (w/v) D,L-homocysteine, Batch, temperature 293K
Resolution 1.40 Å R-free 0.233
3SZK Crystal Structure of Human metHaemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus Deposited 2011-07-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain E 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.2M potassium thiocyanate, 0.1M Tris-bis propane, 20% PEG 3350 , pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.01 Å R-free 0.275
3SZK Crystal Structure of Human metHaemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus Deposited 2011-07-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.2M potassium thiocyanate, 0.1M Tris-bis propane, 20% PEG 3350 , pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.01 Å R-free 0.275
3W4U Human zeta-2 beta-2-s hemoglobin Deposited 2013-01-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Mutation：E7V Mutation：E7V HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.4；298 K；3.1M sodium potassium phosphate, pH 6.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.95 Å R-free 0.255
3W4U Human zeta-2 beta-2-s hemoglobin Deposited 2013-01-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Mutation：E7V HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.4；298 K；3.1M sodium potassium phosphate, pH 6.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.95 Å R-free 0.255
3WCP Deoxyhemoglobin SH-drug complex Deposited 2013-05-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEM PROTOPORPHYRIN IX CONTAINING FE × 4 DG2 (2R)-2,3-diphosphoglyceric acid × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.6；298 K；0.2M sodium acetate trihydrate, 0.1M sodium cacodylate trihydrate, 30% PEG8000, pH 6.6, batch, temperature 298K
Resolution 1.94 Å R-free 0.263
3WHM Structure of Hemoglobin Complex with 18-crown-6 Deposited 2013-08-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain F 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 5 OXY OXYGEN MOLECULE × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；30% (w/v) PEG 3350, 0.2M Lithium sulfate, 0.1M Tris pH 8.0, 25mM 18-crown-6, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 1.85 Å R-free 0.253
4FC3 Crystal Structure of Human Methaemoglobin Complexed with the Second NEAT Domain of IsdH from Staphylococcus aureus Deposited 2012-05-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.2M Sodium formate, 0.1M bis-tris propane, 20% PEG3350, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.26 Å R-free 0.256
4HHB THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION Deposited 1984-03-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.74 Å
4IJ2 Human methemoglobin in complex with the second and third NEAT domains of IsdH from Staphylococcus aureus Deposited 2012-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.6；294 K；0.2M diammonium citrate, 13%(w/v) PEG3350, 0.7% 1-butanol, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 4.24 Å R-free 0.310
4L7Y Deoxygenated Hb in complex with the allosteric effectors, IRL2500 and 2,3-DPG Deposited 2013-06-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded MH0 Mesoheme × 4 IRL (2R)-2-({(2S)-3-(biphenyl-4-yl)-2-[(3,5-dimethylbenzoyl)(methyl)amino]propanoyl}amino)-3-(1H-indol-3-yl)propanoic acid (non-preferred name) × 1 DG2 (2R)-2,3-diphosphoglyceric acid × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.6；297 K；0.2M sodium acetate trihydrate, 0.1M sodium cacodylate trihydrate,30% PEG8000, pH 6.6, LIQUID DIFFUSION, temperature 297K
Resolution 1.80 Å R-free 0.228
4M4A Human Hemoglobin Nitromethane Modified Deposited 2013-08-06 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NSM NITROSOMETHANE × 4 GOL GLYCEROL × 6 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；295 K；sodium phosphate, potassium phosphate, toluene, pH 6.8, LIQUID DIFFUSION, temperature 295K
Resolution 2.05 Å R-free 0.280
4M4B Human Hemoglobin Nitroethane Modified Deposited 2013-08-06 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 2 NOE NITROSOETHANE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；295 K；sodium phosphate, potassium phosphate, toluene, pH 6.8, LIQUID DIFFUSION, temperature 295K
Resolution 2.00 Å R-free 0.270
4MQC Carbonmonoxy Structure of Hemoglobin Evans alphaV62Mbetawt Deposited 2013-09-16 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；Protein crystallized from 2.2M Sodium/Potassium Phosphate, batch method, pH 6.7, LIQUID DIFFUSION, temperature 298K
Resolution 2.20 Å R-free 0.250
4MQG Structure of Carbonmonoxy Adult Hemoglobin Bristol-Alesha alphawtbetaV67M Deposited 2013-09-16 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；Protein crystallized from 1.9M Sodium/Potassium Phosphate, Batch method, pH 7.0, LIQUID DIFFUSION, temperature 298K
Resolution 1.68 Å R-free 0.243
4MQH Structure of Aquomet Hemoglobin Evans alphaV62Mbetawt Deposited 2013-09-16 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；Protein crystallized from 2.2M Sodium/Potassium Phosphate, pH 6.7, Batch method, temperature 298K, LIQUID DIFFUSION
Resolution 2.50 Å R-free 0.250
4MQI Structure of Aquomet Hemoglobin Bristol-Alesha alphawtbetaV67M Deposited 2013-09-16 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.7；298 K；Protein crystallized from 2.2M Sodium/Potassium Phosphate, pH 6.7, Batch method, temperature 298K, LIQUID DIFFUSION
Resolution 1.92 Å R-free 0.239
4N7N Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of full-liganded human haemoglobin with phosphate at 2.75 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa） Fragment：UNP residues 2-147
Chain D 2–147（146 aa） Fragment：UNP residues 2-147
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 6.8；298 K；18% PEG3350, 5% glycerol , pH 6.8, microbatch under paraffin oil, temperature 298K
Resolution 2.75 Å R-free 0.286
4N7N Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of full-liganded human haemoglobin with phosphate at 2.75 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa） Fragment：UNP residues 2-147
Chain H 2–147（146 aa） Fragment：UNP residues 2-147
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 6.8；298 K；18% PEG3350, 5% glycerol , pH 6.8, microbatch under paraffin oil, temperature 298K
Resolution 2.75 Å R-free 0.286
4N7N Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of full-liganded human haemoglobin with phosphate at 2.75 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain J 2–147（146 aa） Fragment：UNP residues 2-147
Chain L 2–147（146 aa） Fragment：UNP residues 2-147
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 6.8；298 K；18% PEG3350, 5% glycerol , pH 6.8, microbatch under paraffin oil, temperature 298K
Resolution 2.75 Å R-free 0.286
4N7O Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin with phosphate at 2.5 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa） Fragment：UNP residues 2-147
Chain D 2–147（146 aa） Fragment：UNP residues 2-147
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 6.8；298 K；CO-saturated 1.0% XL[alpha(Fe-Co)beta(Ni)][alpha(Ni)beta(Fe-Co)], 17% PEG3350, 10mM Potassium phosphate pH6.8 , microbatch under paraffin oil, temperature 298K
Resolution 2.50 Å R-free 0.292
4N7O Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin with phosphate at 2.5 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa） Fragment：UNP residues 2-147
Chain H 2–147（146 aa） Fragment：UNP residues 2-147
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 6.8；298 K；CO-saturated 1.0% XL[alpha(Fe-Co)beta(Ni)][alpha(Ni)beta(Fe-Co)], 17% PEG3350, 10mM Potassium phosphate pH6.8 , microbatch under paraffin oil, temperature 298K
Resolution 2.50 Å R-free 0.292
4N7O Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin with phosphate at 2.5 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain J 2–147（146 aa） Fragment：UNP residues 2-147
Chain L 2–147（146 aa） Fragment：UNP residues 2-147
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 6.8；298 K；CO-saturated 1.0% XL[alpha(Fe-Co)beta(Ni)][alpha(Ni)beta(Fe-Co)], 17% PEG3350, 10mM Potassium phosphate pH6.8 , microbatch under paraffin oil, temperature 298K
Resolution 2.50 Å R-free 0.292
4N7P Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin without phosphate at 2.8 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa） Fragment：UNP residues 2-147
Chain D 2–147（146 aa） Fragment：UNP residues 2-147
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 7.6；298 K；pH 7.6, microbatch under paraffin oil, temperature 298K
Resolution 2.81 Å R-free 0.287
4N7P Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin without phosphate at 2.8 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa） Fragment：UNP residues 2-147
Chain H 2–147（146 aa） Fragment：UNP residues 2-147
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 7.6；298 K；pH 7.6, microbatch under paraffin oil, temperature 298K
Resolution 2.81 Å R-free 0.287
4N7P Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin without phosphate at 2.8 A resolution. Deposited 2013-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain J 2–147（146 aa） Fragment：UNP residues 2-147
Chain L 2–147（146 aa） Fragment：UNP residues 2-147
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions microbatch under paraffin oil；pH 7.6；298 K；pH 7.6, microbatch under paraffin oil, temperature 298K
Resolution 2.81 Å R-free 0.287
4N8T Human hemoglobin nitric oxide adduct Deposited 2013-10-18 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 6 NO2 NITRITE ION × 2 NO NITRIC OXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；295 K；SOLDIUM PHOSPHATE, POTASSIUM PHOSPHATE, TOLUENE, HUMAN HEMOGLOBIN, pH 6.8, LIQUID DIFFUSION, temperature 295K
Resolution 1.90 Å R-free 0.252
4NI0 Quaternary R3 CO-liganded hemoglobin structure in complex with a thiol containing compound Deposited 2013-11-05 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 2P3 5-[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione × 8 MBN TOLUENE × 6 PO4 PHOSPHATE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；298 K；20-30mg/mL protein, 3.0-3.4 M Sodium/potassium phosphate, pH 6.8, LIQUID DIFFUSION, temperature 298K
Resolution 2.15 Å R-free 0.259
4NI1 Quaternary R CO-liganded hemoglobin structure in complex with a thiol containing compound Deposited 2013-11-05 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 2JX 5-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione × 8 MBN TOLUENE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.4；298 K；20-30mg/mL protein, 3.0-3.4 M sodium/potassium phosphate, pH 6.4, LIQUID DIFFUSION, temperature 298K
Resolution 1.90 Å R-free 0.259
4ROL Deoxyhemoglobin in complex with imidazolylacryloyl derivatives Deposited 2014-10-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 3U7 4-{2,3-dichloro-4-[3-(1H-imidazol-2-yl)propanoyl]phenoxy}butanoic acid × 2 SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；298 K；3.2 M sulfate/phosphate precipitant, pH 6.8, LIQUID DIFFUSION, temperature 298K
Resolution 1.70 Å R-free 0.205
4ROM Deoxyhemoglobin in complex with imidazolylacryloyl derivatives Deposited 2014-10-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 3U8 4-{2-chloro-4-[3-(1H-imidazol-2-yl)propanoyl]phenoxy}butanoic acid × 2 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.8；298 K；3.2 M sulfate/phosphate precipitant, pH 6.8, LIQUID DIFFUSION, temperature 298K
Resolution 1.90 Å R-free 0.248
4WJG Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin Deposited 2014-09-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 10 PDB declaration: Decameric
Chain B 2–147（146 aa）
Chain G 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；277 K；15% Polyethylene glycol (PEG) 1500, 0.1M Bis-Tris
Resolution 3.10 Å R-free 0.271
4WJG Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin Deposited 2014-09-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Other combination Heteromer；Protein × 10 PDB declaration: Decameric
Chain L 2–147（146 aa）
Chain Q 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；277 K；15% Polyethylene glycol (PEG) 1500, 0.1M Bis-Tris
Resolution 3.10 Å R-free 0.271
4WJG Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin Deposited 2014-09-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Other combination Heteromer；Protein × 10 PDB declaration: Decameric
Chain 1 2–147（146 aa）
Chain V 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；277 K；15% Polyethylene glycol (PEG) 1500, 0.1M Bis-Tris
Resolution 3.10 Å R-free 0.271
4X0L Human haptoglobin-haemoglobin complex Deposited 2014-11-21 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 GOL GLYCEROL × 2 SO4 SULFATE ION × 1 CAC CACODYLATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M NaCl, 0.1 M sodium cacodylate pH 6.5 and 2 M ammonium sulphate
Resolution 2.05 Å R-free 0.224
4XS0 Human methemoglobin in complex with the second and third NEAT domains of IsdH(F365Y/A369F/Y642A) from Staphylococcus aureus Deposited 2015-01-21 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CL CHLORIDE ION × 3 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；0.2 M K/Na tartrate, 0.1 M tri-sodium citrate pH 5.6, 2 M ammonium sulfate. Cryoprotected in 20% glycerol.
Resolution 2.55 Å R-free 0.287
5E29 Crystal Structure of Deoxygenated Hemoglobin in Complex with an Allosteric Effector and Nitric Oxide Deposited 2015-09-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 3–147（145 aa）
Chain D 3–147（145 aa）
Not recorded NO NITRIC OXIDE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 5JN 2-(nitrooxy)ethyl 2-(4-{2-[(3,5-dimethylphenyl)amino]-2-oxoethyl}phenoxy)-2-methylpropanoate × 1 RQ3 2-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID × 2 NO3 NITRATE ION × 2 CAC CACODYLATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；295 K；0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate trihydrate, pH 6.5, 30% w/v PEG8000, anaerobic conditions
Resolution 1.85 Å R-free 0.253
5E6E Crystal Structure of Carbonmonoxy Sickle Hemoglobin in R-State Conformation Deposited 2015-10-09 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 4 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.6；293 K；3.2 M phosphate
Resolution 1.76 Å R-free 0.243
5E83 CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT440, CO-CRYSTALLIZATION EXPERIMENT Deposited 2015-10-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 5L7 2-methyl-3-({2-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-3-yl}methoxy)phenol × 1 GOL GLYCEROL × 3 UNL UNKNOWN LIGAND × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.4；294 K；0.1M HEPES, 25% PEG4000, PH 7.4, 40 MM NACL
Resolution 1.80 Å R-free 0.207
5EE4 The crystal structure of HpuA from Kingella denitrificans in complex with human haemoglobin Deposited 2015-10-22 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain D 2–147（146 aa）
Not recorded GOL GLYCEROL × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.8；277 K；100 mM Hepes, 18 % Peg 4,000, 10 % Isopropanol
Resolution 2.30 Å R-free 0.244
5EE4 The crystal structure of HpuA from Kingella denitrificans in complex with human haemoglobin Deposited 2015-10-22 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain F 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.8；277 K；100 mM Hepes, 18 % Peg 4,000, 10 % Isopropanol
Resolution 2.30 Å R-free 0.244
5HU6 Structure of the T. brucei haptoglobin-haemoglobin receptor bound to human haptolgobin-haemoglobin Deposited 2016-01-27 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 3–143（141 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；12.5% v/v MPD, 0.03 M NaBr, 0.03M NaI, 0.03M NaF, 0.1 M MES/imidazole pH 6.5, 12.5% w/v PEG 1000, 12.5% w/v PEG 3350
Resolution 2.90 Å R-free 0.226
5HY8 Glycation restrains allosteric transition in hemoglobin: The molecular basis of oxidative stress under hyperglycemic conditions in diabetes Deposited 2016-02-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Chain H 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 FRU beta-D-fructofuranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；PEG 4000
Resolution 2.30 Å R-free 0.244
5HY8 Glycation restrains allosteric transition in hemoglobin: The molecular basis of oxidative stress under hyperglycemic conditions in diabetes Deposited 2016-02-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 FRU beta-D-fructofuranose × 2 GLC alpha-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；PEG 4000
Resolution 2.30 Å R-free 0.244
5HY8 Glycation restrains allosteric transition in hemoglobin: The molecular basis of oxidative stress under hyperglycemic conditions in diabetes Deposited 2016-02-01 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain T 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；PEG 4000
Resolution 2.30 Å R-free 0.244
5JDO T. congolense haptoglobin-haemoglobin receptor in complex with haemoglobin Deposited 2016-04-17 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain D 3–147（145 aa）
Chain F 3–146（144 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；0.1 M sodium citrate pH 5, 8% w/v PEG 8000
Resolution 3.20 Å R-free 0.235
5KDQ Deoxyhemoglobin in Complex with an Aryloxyalkanoic acid Deposited 2016-06-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PO4 PHOSPHATE ION × 2 KOH 3-[2-chloranyl-4-(1~{H}-imidazol-2-yl)phenoxy]propanoic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；3.2 M Sulfate/phosphate precipitant, pH 6.8, LIQUID DIFFUSION
Resolution 2.15 Å R-free 0.257
5KSI Crystal structure of deoxygenated hemoglobin in complex with sphingosine phosphate and 2,3-Bisphosphoglycerate Deposited 2016-07-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 S1P (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate × 5 DG2 (2R)-2,3-diphosphoglyceric acid × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate trihydrate, pH 6.5 and 30% PEG 8000
Resolution 1.80 Å R-free 0.220
5KSJ Crystal structure of deoxygenated hemoglobin in complex with Sphingosine phosphate Deposited 2016-07-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 S1P (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.5；298 K；0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate trihydrate, pH 6.5 and 30% PEG 8000
Resolution 2.40 Å R-free 0.287
5NI1 CryoEM structure of haemoglobin at 3.2 A determined with the Volta phase plate Deposited 2017-03-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.20 Å
5SW7 Structure of the Human Hemoglobin Mutant Hb Providence (A-Gly-C:V1M; B,D:V1M,K82D; Ferrous, carbonmonoxy bound) Deposited 2016-08-08 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Mutation：V1M,K82D HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；296 K；2.5M sodium/potassium phosphate
Resolution 1.85 Å R-free 0.222
5U3I CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT compound 31 Deposited 2016-12-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Mutation：E6V Mutation：E6V HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 7SJ 2-methoxy-5-({2-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-3-yl}methoxy)pyridine-4-carbaldehyde × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；100 mM Hepes pH 7.4 20 mM NaCl 30 % PEG 3350
Resolution 1.95 Å R-free 0.253
5UCU STRUCTURAL AND MECHANISTIC INSIGHTS INTO HEMOGLOBIN-CATALYZED HYDROGEN SULFIDE OXIDATION AND THE FATE OF POLYSULFIDE PRODUCTS Deposited 2016-12-22 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 H2S HYDROSULFURIC ACID × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293.15 K；10% Toluene, 2.3 M K2HPO4/NH2PO4 pH, 7.2.
Resolution 1.80 Å R-free 0.222
5UFJ Crystal Structure of Carbonmonoxy Hemoglobin S (Liganded Sickle Cell Hemoglobin) Complexed with GBT Compound 6 Deposited 2017-01-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Mutation：E6V Mutation：E6V HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 86M 5-[(imidazo[1,2-a]pyridin-8-yl)methoxy]-2-methoxypyridine-4-carbaldehyde × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；0.1 M Hepes pH 7.4, 40 mM NaCl, 29 % PEG3350
Resolution 2.05 Å R-free 0.254
5URC Design, Synthesis, Functional and Biological Evaluation of Ether and Ester Derivatives of the Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease Deposited 2017-02-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 8MV (5-formylfuran-2-yl)methyl acetate × 1 FUX 5-HYDROXYMETHYL-FURFURAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.4；298 K；25% PEG4000, 0.1 M Hepes, 40 mM Sodium Chloride
Resolution 1.85 Å R-free 0.223
5VMM Staphylococcus aureus IsdB bound to human hemoglobin Deposited 2017-04-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；298 K；0.1 M malonic acid pH 5.5, 2.2 M ammonium sulfate
Resolution 3.60 Å R-free 0.302
5WOG Human Hemoglobin immersed in Liquid Oxygen for 1 minute Deposited 2017-08-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277.15 K；1 mL of 40 mg/mL hemoglobin + 2.65 M (final concentration) phosphate buffer, topped with 100 uL toluene
Resolution 1.54 Å R-free 0.206
5WOH Human Hemoglobin Immersed in Liquid Oxygen for 20 seconds Deposited 2017-08-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277.15 K；1 mL of 40 mg/mL hemoglobin + 2.65 M (final concentration) phosphate buffer, topped with 100 uL toluene
Resolution 1.58 Å R-free 0.207
5X2R Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 10 mM phosphate pH 6.9. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.70 Å R-free 0.306
5X2R Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 10 mM phosphate pH 6.9. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Chain H 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.70 Å R-free 0.306
5X2R Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 10 mM phosphate pH 6.9. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain J 2–147（146 aa）
Chain L 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.70 Å R-free 0.306
5X2S Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 6.5. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.39 Å R-free 0.288
5X2S Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 6.5. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Chain H 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.39 Å R-free 0.288
5X2S Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 6.5. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain J 2–147（146 aa）
Chain L 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 PEM 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.39 Å R-free 0.288
5X2T Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 7.2. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.64 Å R-free 0.277
5X2T Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 7.2. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Chain H 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.64 Å R-free 0.277
5X2T Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 7.2. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain J 2–147（146 aa）
Chain L 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 PEM 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.64 Å R-free 0.277
5X2U Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 80 mM phosphate pH 6.7. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.53 Å R-free 0.274
5X2U Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 80 mM phosphate pH 6.7. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Chain H 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.53 Å R-free 0.274
5X2U Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 80 mM phosphate pH 6.7. Deposited 2017-02-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain J 2–147（146 aa）
Chain L 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
Resolution 2.53 Å R-free 0.274
6BB5 Human Oxy-Hemoglobin Deposited 2017-10-16 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 3–147（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；1 mL 40 mg/mL hemoglobin + 2.65 M (final concentration) phosphate buffer, topped with 100 uL toluene
Resolution 2.28 Å R-free 0.242
6BNR Carbonmonoxy hemoglobin in complex with the antisickling agent 5-methoxy-2-(pyridin-2-ylmethoxy)benzaldehyde (INN310) Deposited 2017-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 E0J 2-[(4-methoxy-2-methylphenoxy)methyl]pyridine × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.4；298 K；25% PEG 6000, 0.1M HEPES (pH 7.4)
Resolution 1.95 Å R-free 0.264
6BWP Crystal structure of Deoxy Hemoglobin in complex with beta Cys93 modifying agent, TD3 Deposited 2017-12-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 EBJ 1H-1,2,3-triazole-5-thiol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.6；293 K；3.4M Na Phosphate/NH4 Sulfate
Resolution 1.70 Å R-free 0.197
6BWU Crystal structure of carboxyhemoglobin in complex with beta Cys93 modifying agent, TD3 Deposited 2017-12-15 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 EBJ 1H-1,2,3-triazole-5-thiol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.6；293 K；3.2M Na/K Phosphate
Resolution 2.00 Å R-free 0.265
6DI4 Rational Modification of Vanillin Derivatives to Stereospecifically Destabilize Sickle Hemoglobin Polymer Formation Deposited 2018-05-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GJ1 {6-[(4-methoxy-2-methylphenoxy)methyl]pyridin-2-yl}methanol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.4；298 K；10-20% PEG6000, 100mM Hepes pH 7.4
Resolution 1.90 Å R-free 0.249
6FQF THE X-RAY STRUCTURE OF FERRIC-BETA4 HUMAN HEMOGLOBIN Deposited 2018-02-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 2–147（146 aa）
Chain B 2–147（146 aa）
Chain C 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；The crystals used in the diffraction experiments were obtained with a protein concentration of 8 mg/ml, at pH 7.0. The composition of the reservoir solution was 2.5 M ammonium sulphate and 0.26 M sodium phosphate buffer at pH 7.0.
Resolution 2.10 Å R-free 0.265
6HAL Human carbonmonoxy hemoglobin SFX dataset Deposited 2018-08-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 3–147（145 aa）
Chain D 3–147（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7；293 K；batch crystallization, using 1.6 M Na/K phosphate, neutal pH as precipitant
Resolution 2.20 Å R-free 0.211
6HBW Crystal structure of deoxy-human hemoglobin beta6 glu->trp Deposited 1998-09-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–146（146 aa）
Chain D 1–146（146 aa）
Mutation：E6W Mutation：E6W HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；PROTEIN WAS RESUSPENDED IN 30 MM PHOSPHATE BUFFER, PH 7.0, DEOXYGENATED AND CONCENTRATED TO 160 MG/ML. PROTEIN WAS CRYSTALLIZED IN AN ANAEROBIC CHAMBER IN TUBE CONTAINING 10 UL PROTEIN SOLUTION, 5 UL CITRATE BUFFER (PH 4.0), AND 4UL OF 33% PEG 8K.
Resolution 2.00 Å R-free 0.264
6HK2 Crystal structure of ferric R-state human methemoglobin bound to maleimide-deferoxamine bifunctional chelator (DFO) Deposited 2018-09-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 1 SO4 SULFATE ION × 7 G7Z 3-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]-~{N}-methyl-propanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；293 K；2.4 M (NH4)2SO4, 0.23 M (NH4)2HPO4, 0.07 M (NH4)H2PO4
Resolution 1.55 Å R-free 0.212
6KA9 Crosslinked alpha(Fe-CO)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-06-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；18%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.40 Å R-free 0.191
6KA9 Crosslinked alpha(Fe-CO)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-06-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Chain H 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；18%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.40 Å R-free 0.191
6KAE Crosslinked alpha(Fe-CO)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-06-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 8 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；18%w/v PEG3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.45 Å R-free 0.200
6KAE Crosslinked alpha(Fe-CO)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-06-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Chain H 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 8 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；18%w/v PEG3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.45 Å R-free 0.200
6KAH Crosslinked alpha(Ni)-beta(Fe-CO) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-06-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；20%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.45 Å R-free 0.196
6KAH Crosslinked alpha(Ni)-beta(Fe-CO) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-06-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Chain H 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；20%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.45 Å R-free 0.196
6KAI Crosslinked alpha(Ni)-beta(Fe) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-06-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 CMO CARBON MONOXIDE × 7 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；20%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.45 Å R-free 0.202
6KAI Crosslinked alpha(Ni)-beta(Fe) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-06-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Chain H 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 CMO CARBON MONOXIDE × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；20%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
Resolution 1.45 Å R-free 0.202
6KAO Carbonmonoxy human hemoglobin C in the R quaternary structure at 95 K: Dark Deposited 2019-06-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
Resolution 1.40 Å R-free 0.211
6KAP Carbonmonoxy human hemoglobin C in the R quaternary structure at 95 K: Light Deposited 2019-06-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
Resolution 1.45 Å R-free 0.211
6KAQ Carbonmonoxy human hemoglobin C in the R quaternary structure at 140 K: Dark Deposited 2019-06-24 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
Resolution 1.50 Å R-free 0.220
6KAR Carbonmonoxy human hemoglobin C in the R quaternary structure at 140 K: Light Deposited 2019-06-24 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
Resolution 1.60 Å R-free 0.226
6KAS Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 95 K: Dark Deposited 2019-06-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 5.8；293 K；18%w/v PEG6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
Resolution 1.65 Å R-free 0.202
6KAT Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 95 K: Light Deposited 2019-06-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 5.8；293 K；18%w/v PEG 6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
Resolution 1.70 Å R-free 0.203
6KAU Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 140 K: Dark Deposited 2019-06-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 5.8；293 K；18%w/v PEG6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
Resolution 1.60 Å R-free 0.213
6KAV Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 140 K: Light Deposited 2019-06-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 5.8；293 K；18%w/v PEG6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
Resolution 1.70 Å R-free 0.205
6KYE The crystal structure of recombinant human adult hemoglobin Deposited 2019-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–147（147 aa）
Chain D 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6；293 K；NaCl, PEG3350, MES
Resolution 2.28 Å R-free 0.268
6KYE The crystal structure of recombinant human adult hemoglobin Deposited 2019-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 1–147（147 aa）
Chain H 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6；293 K；NaCl, PEG3350, MES
Resolution 2.28 Å R-free 0.268
6KYE The crystal structure of recombinant human adult hemoglobin Deposited 2019-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain J 1–147（147 aa）
Chain L 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6；293 K；NaCl, PEG3350, MES
Resolution 2.28 Å R-free 0.268
6L5V Carbonmonoxy human hemoglobin C in the R quaternary structure at 95 K: Light (2 min) Deposited 2019-10-24 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
Resolution 1.45 Å R-free 0.213
6L5W Carbonmonoxy human hemoglobin C in the R quaternary structure at 140 K: Light (2 min) Deposited 2019-10-24 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
Resolution 1.50 Å R-free 0.215
6L5X Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 95 K: Light (2 min) Deposited 2019-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 5.8；293 K；18%w/v PEG 6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
Resolution 1.65 Å R-free 0.207
6L5Y Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 140 K: Light (2 min) Deposited 2019-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 5.8；293 K；18%w/v PEG 6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
Resolution 1.65 Å R-free 0.206
6LCW Crosslinked alpha(Ni)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-11-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 4 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；1.0% (w/v) protein solution that contains 18% (w/v) PEG3350, 0.15 M dipotassium sulfate, 50 mM citrate-ammonium buffer (pH 6.6)
Resolution 1.40 Å R-free 0.218
6LCW Crosslinked alpha(Ni)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-11-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Chain H 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 4 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；1.0% (w/v) protein solution that contains 18% (w/v) PEG3350, 0.15 M dipotassium sulfate, 50 mM citrate-ammonium buffer (pH 6.6)
Resolution 1.40 Å R-free 0.218
6LCX Crosslinked alpha(Ni)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-11-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 4 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；1.0% (w/v) protein solution that contains 18% (w/v) PEG 3350, 0.15 M dipotassium sulfate, 50 mM citrate-ammonium buffer (pH 6.6)
Resolution 1.40 Å R-free 0.216
6LCX Crosslinked alpha(Ni)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-11-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Chain H 2–147（146 aa）
Not recorded HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 4 2FU BUT-2-ENEDIAL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.6；293 K；1.0% (w/v) protein solution that contains 18% (w/v) PEG 3350, 0.15 M dipotassium sulfate, 50 mM citrate-ammonium buffer (pH 6.6)
Resolution 1.40 Å R-free 0.216
6NBC human methemoglobin state 1 determined using single-particle cryo-EM at 200 keV Deposited 2018-12-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–144（143 aa）
Chain D 2–144（143 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Sample was manually blotted for 4-5 seconds using Whatman No. 1 filter paper immediately prior to plunge-freezing.
Resolution 2.80 Å
6NBD Human methemoglobin state 2 determined using single-particle cryo-EM at 200 keV Deposited 2018-12-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–144（143 aa）
Chain D 2–144（143 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；Sample was manually blotted for 4-5 seconds using Whatman No. 1 filter paper immediately prior to plunge-freezing.
Resolution 3.20 Å
6NQ5 human (alpha met/beta hemichrome) hemoglobin with S-nitrosation at beta-Cys93 Deposited 2019-01-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FE FE (III) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；298 K；sodium phosphate, potassium phosphate, toluene
Resolution 1.85 Å R-free 0.282
6TB2 Structure of human haptoglobin-hemoglobin bound to S. aureus IsdH Deposited 2019-10-31 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M sodium citrate tribasic dihydrate, 20 % w/v PEG 3350
Resolution 2.90 Å R-free 0.270
6XD9 Carbonmonoxy hemoglobin in complex with the antisickling agent 2-hydroxy-6-((6-(hydroxymethyl)pyridin-2-yl)methoxy)benzaldehyde (VZHE039) Deposited 2020-06-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 V39 3-{[6-(hydroxymethyl)pyridin-2-yl]methoxy}-2-methylphenol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.4；298 K；25% PEG 6000, 0.1M HEPES
Resolution 2.10 Å R-free 0.258
6XDT Carbonmonoxy hemoglobin in complex with the antisickling agent methyl 5-((2-formyl-4-methoxyphenoxy)methyl)picolinate Deposited 2020-06-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 V1M methyl 5-[(4-methoxy-2-methylphenoxy)methyl]pyridine-2-carboxylate × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.4；298 K；25% PEG 6000, 100 mM HEPES buffer
Resolution 1.90 Å R-free 0.239
6XE7 Carbonmonoxy hemoglobin in complex with the antisickling agent methyl 2-((2-formyl-3-hydroxyphenoxy)methyl)nicotinate Deposited 2020-06-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 V2D methyl 2-[(3-hydroxy-2-methylphenoxy)methyl]pyridine-3-carboxylate × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.4；298 K；25% PEG 6000, 10 mM HEPES
Resolution 2.00 Å R-free 0.251
7AET Pressure wave-exposed human hemoglobin: probe only data (3500 indexed images) Deposited 2020-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain BBB 3–147（145 aa）
Chain DDD 3–147（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；293 K；3.2 M NaH2PO4/ 3.2 M K2HPO4 in a 2:1 ratio
Resolution 2.53 Å R-free 0.288
7AEU Pressure wave-exposed human hemoglobin: probe only data (5500 indexed images) Deposited 2020-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain BBB 3–147（145 aa）
Chain DDD 3–147（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；293 K；3.2 M NaH2PO4/ 3.2 M K2HPO4 in a 2:1 ratio
Resolution 2.54 Å R-free 0.273
7AEV Pressure wave-exposed human hemoglobin: pump/probe data (3500 indexed images) Deposited 2020-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain BBB 3–147（145 aa）
Chain DDD 3–147（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；293 K；3.2 M NaH2PO4/ 3.2 M K2HPO4 in a 2:1 ratio
Resolution 2.77 Å R-free 0.273
7CUE Crystal structure of HID2 bound to human Hemoglobin Deposited 2020-08-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain B 1–147（147 aa）
Chain D 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；293.15 K；23% PEG 3350 (w/v), 100mM ammonium sulfate, 100mM BIS-TRIS
Resolution 2.75 Å R-free 0.259
7DY3 High resolution crystal structure of hemoglobin M Iwate. Deposited 2021-01-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；25%w/v PEG 3350, 0.1M HEPES-NaOH buffer, 0.2M lithium sulfate, pH 7.5
Resolution 1.40 Å R-free 0.193
7DY3 High resolution crystal structure of hemoglobin M Iwate. Deposited 2021-01-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Chain H 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；25%w/v PEG 3350, 0.1M HEPES-NaOH buffer, 0.2M lithium sulfate, pH 7.5
Resolution 1.40 Å R-free 0.193
7DY4 High resolution crystal structure of hemoglobin M Boston. Deposited 2021-01-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；20% w/v PEG 3350, 0.1M Bistris-HCl buffer, 0.2M magnesium chloride, pH 6.0
Resolution 1.30 Å R-free 0.186
7DY4 High resolution crystal structure of hemoglobin M Boston. Deposited 2021-01-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Chain H 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；20% w/v PEG 3350, 0.1M Bistris-HCl buffer, 0.2M magnesium chloride, pH 6.0
Resolution 1.30 Å R-free 0.186
7JJQ Human Hemoglobin in Complex with Nitrosoamphetamine Deposited 2020-07-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 1 K7M (2R)-N-hydroxy-1-phenylpropan-2-amine × 3 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.74；298 K；3.2M Na/K phosphate buffer
Resolution 2.15 Å R-free 0.286
7JXZ Structure of HbA with compound (S)-4 Deposited 2020-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 5 VOJ 3-{(1S)-1-[5-fluoro-2-(1H-pyrazol-1-yl)phenyl]ethoxy}-5-(3-methyl-1H-pyrazol-4-yl)pyridin-2-amine × 2 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.1 M Tris-HCl, pH 8.0, 0.2 M lithium sulfate, 30-32% PEG3350
Resolution 2.23 Å R-free 0.247
7JY0 Structure of HbA with compound 9 Deposited 2020-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 6 VOM 2-amino-3-{(1S)-1-[5-fluoro-2-(1H-pyrazol-1-yl)phenyl]ethoxy}quinoline-6-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl, pH 8.0, 0.2 M lithium sulfate, 30-32% PEG3350
Resolution 1.63 Å R-free 0.197
7JY1 Structure of HbA with compound 19 Deposited 2020-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 7 VOP [6-{(1S)-1-[(2-amino-6-fluoroquinolin-3-yl)oxy]ethyl}-5-(1H-pyrazol-1-yl)-1H-indazol-1-yl]acetic acid × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl, pH 8.0, 0.2 M lithium sulfate, 30-32% PEG3350
Resolution 1.59 Å R-free 0.193
7JY3 Structure of HbA with compound 23 (PF-07059013) Deposited 2020-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 5 VUD 6-{(1S)-1-[(2-amino-6-fluoroquinolin-3-yl)oxy]ethyl}-5-(1H-pyrazol-1-yl)pyridin-2(1H)-one × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl, pH 8.0, 0.2 M lithium sulfate, 30-32% PEG3350
Resolution 1.48 Å R-free 0.207
7PCF Human methemoglobin bound to Staphylococcus aureus hemophore IsdB Deposited 2021-08-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2；CHAPSO was added immediately before plunge freezing to overcome preferred orientation of the particles in the vitreous ice.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.82 Å
7PCH Human carboxyhemoglobin bound to Staphylococcus aureus hemophore IsdB - 1:2 complex Deposited 2021-08-03 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2；CHAPSO was added immediately before plunge freezing to overcome preferred orientation of the particles in the vitreous ice.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.89 Å
7PCQ Human carboxyhemoglobin bound to Staphylococcus aureus hemophore IsdB - 1:1 complex Deposited 2021-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2；CHAPSO was added immediately before plunge freezing to overcome preferred orientation of the particles in the vitreous ice.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.62 Å
7UD7 Crystal structure of deoxygenated hemoglobin in complex with 5HMF-NO at 1.8 Angstrom Deposited 2022-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–147（147 aa）
Chain D 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MWC dihydroxy[(5-methylfuran-2-yl)methoxy]amine × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；3.2-3.6M Sulfate/phosphate precipitant, pH 6.5, ferrous citrate
Resolution 1.80 Å R-free 0.191
7UD8 Crystal structure of carbon monoxy Hemoglobin in complex with 5HMF at 1.8 Angstrom Deposited 2022-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–147（147 aa）
Chain D 1–147（147 aa）
Not recorded OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MW0 (5-methylfuran-2-yl)methanol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；3.2-3.6M Sulfate/phosphate precipitant, pH 6.5, ferrous citrate
Resolution 1.80 Å R-free 0.228
7UF6 Crystal structure of liganded Hb with the 5-HMF analog, MMA509 Deposited 2022-03-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–147（147 aa）
Chain D 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 N1X (2S)-2-(5-methylfuran-2-yl)oxane × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；293 K；30 mg/dL of CO-ligated Hb crystallized using 10-20% PEG 6000, 100 mM Hepes, pH 7.4
Resolution 2.00 Å R-free 0.239
7UF7 Crystal structure of liganded Hb with the 5-HMF analog, MMA503 Deposited 2022-03-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–147（147 aa）
Chain D 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 N2Q (5P)-5-(5-methylfuran-2-yl)-1H-pyrazole × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；293 K；30 mg/dL of CO-ligated Hb crystallized using 10-20% PEG 6000, 100 mM Hepes, pH 7.4
Resolution 2.00 Å R-free 0.223
7UVB CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT021601 Deposited 2022-04-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Mutation：E6V Mutation：E6V HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FOR FORMYL GROUP × 4 OHF 2-hydroxy-6-({(3S)-4-[2-(2-hydroxyethyl)pyridine-3-carbonyl]morpholin-3-yl}methoxy)benzaldehyde × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；296 K；100 mM Hepes pH 7.4, 20 mM NaCl, 28-33% PEG 3350
Resolution 2.05 Å R-free 0.277
7VDE 3.6 A structure of the human hemoglobin Deposited 2021-09-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–147（147 aa）
Chain D 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
7XGY cryo-EM structure of hemoglobin Deposited 2022-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–147（147 aa）
Chain D 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
8DOV Crystal structure of the Shr Hemoglobin Interacting Domain 2 (HID2) in complex with Hemoglobin Deposited 2022-07-14 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain B 2–147（146 aa） Fragment：Hb_alpha
Chain D 2–147（146 aa） Fragment：Hb_alpha
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；295 K；11% PEG-6000, 100mM sodium acetate, 240mM lithium chloride
Resolution 2.10 Å R-free 0.238
8DOV Crystal structure of the Shr Hemoglobin Interacting Domain 2 (HID2) in complex with Hemoglobin Deposited 2022-07-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain F 2–147（146 aa） Fragment：Hb_alpha
Chain H 2–147（146 aa） Fragment：Hb_alpha
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；295 K；11% PEG-6000, 100mM sodium acetate, 240mM lithium chloride
Resolution 2.10 Å R-free 0.238
8EGI X-ray structure of carbonmonoxy hemoglobin in complex with VZHE039-NO Deposited 2022-09-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–147（147 aa）
Chain D 1–147（147 aa）
Not recorded CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 VZN {6-[(3-hydroxy-2-methylphenoxy)methyl]pyridin-2-yl}methyl nitrate × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；30 mg/dL of CO-ligated Hb crystallized using 10-20% PEG 6000, 100 mM Hepes, pH 7.4
Resolution 2.30 Å R-free 0.251
8FDK Phenylhydroxylamine in Reaction with Human Hemoglobin Deposited 2022-12-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NBE NITROSOBENZENE × 5 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.81；298 K；3.2 M sodium/potassium phosphate
Resolution 1.89 Å R-free 0.246
8FDL Human Hemoglobin with Nitrosochloramphenicol Deposited 2022-12-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 8 GOL GLYCEROL × 4 XQU nitrosochloramphenicol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.4；293 K；3.6 M ammonium phosphate/sulfate
Resolution 1.75 Å R-free 0.210
8FDM Human Hemoglobin in Complex with Nitrosomethane Deposited 2022-12-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa） Fragment：Hb_alpha
Chain D 2–147（146 aa） Fragment：Hb_alpha
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 5 MBN TOLUENE × 2 NSM NITROSOMETHANE × 2 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；298 K；3.2 M sodium/potassium phosphate
Resolution 1.91 Å R-free 0.253
8FDN Human Hemoglobin with N-tertbutylhydroxylamine Deposited 2022-12-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa） Fragment：Hb_alpha
Chain D 2–147（146 aa） Fragment：Hb_alpha
Not recorded GOL GLYCEROL × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 XQZ N-T-Butylhydroxylamine × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；298 K；3.2 M sodium/potassium phosphate
Resolution 2.20 Å R-free 0.291
8VYL The structure of Human Hemoglobin in Complex with Nanobody BtNbE11 Deposited 2024-02-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain B 1–147（147 aa）
Chain D 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ACE ACETYL GROUP × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.1-0.3M NH4 Acet. pH 5.5, 0.1-0.3M Na Acet., 25% w/v PEG3350
Resolution 2.02 Å R-free 0.266
8WJ0 cryo-EM structure of human haemoglobin in carbonmonoxy form Deposited 2023-09-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.24 Å
8WJ1 cryo-EM structure of human haemoglobin in oxy form Deposited 2023-09-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.27 Å
8WJ2 cryo-EM structure of human haemoglobin in deoxy form Deposited 2023-09-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.35 Å
8WXZ Falcilysin in complex with hemoglobin beta chain peptide Deposited 2023-10-30 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain P 34–48（15 aa）
Not recorded PEG DI(HYDROXYETHYL)ETHER × 1 ACY ACETIC ACID × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.12M monosaccharides, 0.1M imidazole/MES monohydrate pH 6.5, 20% v/v PEG 500, 10% w/v PEG 20000
Resolution 2.30 Å R-free 0.251
8XMP Structure of CD163 in complex with Hb-Hp Deposited 2023-12-27 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric
Chain G 1–147（147 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 10 CA CALCIUM ION × 23 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.11 Å
8XMQ Structure of dimeric CD163 in complex with Hb-Hp Deposited 2023-12-27 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric
Chain G 1–147（147 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 CA CALCIUM ION × 12 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.21 Å
8XMW Local refinement of Hb-Hp bind to CD163 Deposited 2023-12-28 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric
Chain B 1–147（147 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 CA CALCIUM ION × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.94 Å
9AV9 R2-state HbG-Makassar hemoglobin Deposited 2024-03-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Mutation：E6A Mutation：E6A GOL GLYCEROL × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8；298 K；0.1 M TRIS pH 8.0; 26-36% (v/v) PEG 6,000
Resolution 1.94 Å R-free 0.222
9AYZ T-state HbG Makassar hemoglobin Deposited 2024-03-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Mutation：E6A Mutation：E6A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；298 K；0.055 M Citric acid, 0.045 M Bis-Tris propane, pH 4.5, 22% PEG 3,350 under low oxygen conditions on an MBraun anaerobic glove box
Resolution 2.24 Å R-free 0.259
9AYZ T-state HbG Makassar hemoglobin Deposited 2024-03-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 2–147（146 aa）
Chain H 2–147（146 aa）
Mutation：E6A Mutation：E6A HEM PROTOPORPHYRIN IX CONTAINING FE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；298 K；0.055 M Citric acid, 0.045 M Bis-Tris propane, pH 4.5, 22% PEG 3,350 under low oxygen conditions on an MBraun anaerobic glove box
Resolution 2.24 Å R-free 0.259
9CQM Human OxyHb (C1 symmetry) obtained using the SPT Labtech chameleon In the presence of 25 uM sodium dithionite under Al's oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 3–147（145 aa）
Chain D 3–147（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.55 Å
9CQN Human OxyHb (C2 symmetry) obtained using the SPT Labtech chameleon In the presence of 25 uM sodium dithionite under Al's oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 3–147（145 aa）
Chain D 3–147（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.37 Å
9CQO Human metHb (C1 symmetry) obtained using the SPT Labtech chameleon Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa） Fragment：Hb_alpha
Chain D 2–147（146 aa） Fragment：Hb_alpha
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 3.01 Å
9CQP Human metHb (C2 symmetry) obtained using the SPT Labtech chameleon Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa） Fragment：Hb_alpha
Chain D 2–147（146 aa） Fragment：Hb_alpha
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.78 Å
9CQQ Human metHb (C1 symmetry) obtained using the SPT Labtech chameleon under Al's Oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa） Fragment：Hb_alpha
Chain D 2–147（146 aa） Fragment：Hb_alpha
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.91 Å
9CQR Human metHb (C2 symmetry) obtained using the SPT Labtech chameleon under Al's Oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa） Fragment：Hb_alpha
Chain D 2–147（146 aa） Fragment：Hb_alpha
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.70 Å
9CQS Human OxyHb (C1 symmetry) obtained using the SPT Labtech chameleon In the presence of 5 mM sodium dithionite under Al's oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 3–147（145 aa）
Chain D 3–147（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.52 Å
9CQT Human OxyHb (C2 symmetry) obtained using the SPT Labtech chameleon In the presence of 5 mM sodium dithionite under Al's oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 3–147（145 aa）
Chain D 3–147（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.37 Å
9CQU Human OxyHb (C1 symmetry) obtained using the SPT Labtech chameleon In the presence of 20 mM sodium dithionite under Al's oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 3–147（145 aa）
Chain D 3–147（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.72 Å
9CQV Human DeoxyHb (C1 symmetry) obtained using the SPT Labtech chameleon In the presence of 60 mM sodium dithionite under Al's oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa） Fragment：Hb_alpha
Chain D 2–147（146 aa） Fragment：Hb_alpha
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.75 Å
9CQW Human DeoxyHb (C2 symmetry) obtained using the SPT Labtech chameleon In the presence of 60 mM sodium dithionite under Al's oil Deposited 2024-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa） Fragment：Hb_alpha
Chain D 2–147（146 aa） Fragment：Hb_alpha
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
Resolution 2.61 Å
9FHB Cryo-EM structure of human CD163 SRCR2-4 in complex with haptoglobin-hemoglobin Deposited 2024-05-27 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 CA CALCIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.87 Å
9FMU Cryo-EM structure of human CD163 SRCR1-9 in complex with haptoglobin-hemoglobin Deposited 2024-06-07 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain B 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 CA CALCIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.46 Å
9FNO Cryo-EM structure of human CD163 SRCR1-9 in complex with haptoglobin-hemoglobin Deposited 2024-06-10 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain B 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.20 Å
9HBA Crystal structure of C35 bound to Hem Deposited 2024-11-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Chain D 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 6 A1ITR 4-[2-[[5-(1H-indol-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanoylamino]benzoic acid × 3 DMS DIMETHYL SULFOXIDE × 8 CMO CARBON MONOXIDE × 4 ACY ACETIC ACID × 2 SO4 SULFATE ION × 16 PGE TRIETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；3.0 M Ammonium sulfate; 1% (w/v) MPD
Resolution 1.51 Å R-free 0.215
9HEJ Dimeric CD163 bound to human haptoglobin-haemoglobin complex Deposited 2024-11-14 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 1–147（147 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 CA CALCIUM ION × 9 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.82 Å
9HEK Trimeric CD163 bound to human haptoglobin-haemoglobin complex Deposited 2024-11-14 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 1–147（147 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 CA CALCIUM ION × 19 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.15 Å
9NB6 Cryo-EM structure of the CD163/Hp(1-1)Hb complex Deposited 2025-02-13 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain E 1–147（147 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 CA CALCIUM ION × 23 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
9NB8 Cryo-EM structure of the CD163/HpSPHb complex Deposited 2025-02-13 Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 1–147（147 aa）
Not recorded CA CALCIUM ION × 21 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
9S3P Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 3IsdH(alpha2beta):Hbtet complex Deposited 2025-07-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain B 3–147（145 aa）
Chain D 3–147（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE；blot time 3 s
Resolution 3.10 Å
9S4F Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 4 right tail Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 3–147（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE；blot time 3 s
Resolution 4.20 Å
9S4I Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 0 left tail Deposited 2025-07-28 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 2–147（146 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE；blot time 3 s
Resolution 4.00 Å
9S4J Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 0 right tail Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 3–147（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE；blot time 3 s
Resolution 4.10 Å
9S4K Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 4 left tail Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 3–147（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE；blot time 3 s
Resolution 4.00 Å
9SZW Human carboxyhemoglobin bound to full-length Staphylococcus aureus IsdH - IsdH:Hbdim complex Deposited 2025-10-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 3–147（145 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE；blot time 3 s
Resolution 3.14 Å
9TQD CD163 bound to haemoglobin Deposited 2025-12-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric
Chain E 1–147（147 aa）
Chain G 1–147（147 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 CA CALCIUM ION × 16 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
9VIB cryo-EM structure of human haemoglobin in the R2 conformation Deposited 2025-06-18 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.26 Å
9VIB cryo-EM structure of human haemoglobin in the R2 conformation Deposited 2025-06-18 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.26 Å
9VIB cryo-EM structure of human haemoglobin in the R2 conformation Deposited 2025-06-18 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.26 Å
9VIC cryo-EM structure of human haemoglobin in the R conformation Deposited 2025-06-18 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.45 Å
9VIC cryo-EM structure of human haemoglobin in the R conformation Deposited 2025-06-18 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.45 Å
9VIC cryo-EM structure of human haemoglobin in the R conformation Deposited 2025-06-18 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–147（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.45 Å
9WW1 Oxy-bound rHb0.1WT beta homotetramer human hemoglobin Deposited 2025-09-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 2–147（146 aa）
Chain B 2–147（146 aa）
Chain C 2–147（146 aa）
Chain D 2–147（146 aa）
Mutation：V1M, G16A, H116I Mutation：V1M, G16A, H116I Mutation：V1M, G16A, H116I Mutation：V1M, G16A, H116I No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.233

343 other PDB entries and 399 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name HBB_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–146； UniProt 2–147

Membrane protein

Corynebacterium diphtheriae NCTC 13129

UniProt Q6NEE5

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 6 PDB declaration: hexameric（6） Consistent with protein copy count Chain C； UniProt 32–229 Not recorded Hemoglobin subunit alpha × 2 （P69905） Hemoglobin subunit beta × 2 （P68871） HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 6 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；20% PEG-2000 MME, 100 mM Tris, 240 mM TMAO Resolution 1.69 Å R-free 0.215

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9BCJ Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
9BCH Solution structure of the hemoglobin receptor HbpA from Corynebacterium diphtheriae Deposited 2024-04-09 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 32–229（198 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.2；295 K；Ionic strength (raw mmCIF value) 100；Pressure 1
NMR sample composition 0.72 mM [U-100% 13C; U-100% 15N] Hemoglobin receptor HbpA, 50 mM sodium phosphate, 100 mM sodium chloride, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.72 mM [U-100% 13C; U-100% 15N] Hemoglobin receptor HbpA, 50 mM sodium phosphate, 100 mM sodium chloride, 100% D2O | 100% D2O
Resolution not provided

1 other PDB entries and 1 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q6NEE5_CORDI
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–198； UniProt 32–229

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 9bcj

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 9bcj
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2. Structure Basics 2. Structure Basics

Entry ID entry_id9bcj
Deposition date deposition_date2024-04-09
最后修订 last_revision2025-01-08
Structure title titleCrystal structure of human hemoglobin in complex with the HbpA receptor from Corynebacterium diphtheriae
Keywords keywordsComplex, Hemoglobin, heme, beta-sandwich, PROTEIN BINDING; PROTEIN BINDING
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier27.13 Å
Radius of gyration Rg (electron density) rg_electron26.53 Å
Forward intensity I(0) i043569700.00
Molecular weight molecular_weight52294.0 kDa
Excluded volume excluded_volume65808 ų
Envelope volume envelope_volume79419 ų
Hydration-shell volume shell_volume26237 ų
Envelope diameter envelope_diameter98.5 Å
Shell Rg shell_rg32.35 Å
Envelope Rg envelope_rg26.74 Å
Shape Rg shape_rg26.52 Å
Total Rg total_rg27.20 Å
Total atoms total_atoms3691
Residues n_residues471
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax93.0 Å
Rg (real space) rg_real27.22 Å
Rg uncertainty (real space) rg_real_error0.84 Å
I(0) (real space) i0_real4.3570e+07
I(0) uncertainty (real space) i0_real_error6.6580e+05
Rg (reciprocal space) rg_reciprocal27.20 Å
I(0) (reciprocal space) i0_reciprocal43570000.0000
Solution quality estimate total_estimate0.8748
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks2
Primary peak position r_peak_primary27.3 Å
Skewness Skewness skewness0.418
Kurtosis Kurtosis kurtosis-0.308
Angular range angular_range— – 0.2900 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha10520000.0000
Real-space data points n_real_points59
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.826; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.927; Smooth: 0.964
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (7)

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8. Citations (1)

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9. Files and Curves (10)