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9gz1

Beta-cardiac myosin interacting heads motif complexed to mavacamten

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Myosin-7

Homo sapiens

UniProt P12883

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Myosin light chain 1/3, skeletal muscle isoform × 2 （P05977） Myosin regulatory light chain 11 × 2 （P97457） MAGNESIUM ION × 4 ADENOSINE-5'-DIPHOSPHATE × 2 PHOSPHATE ION × 2 Mavacamten × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4db1 4db1 9gz2 9gz3 9htf 9htg 9i8p

7 assemblies

Homodimer
2fxm 2fxo 2fxo 4db1

4 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3dtp 3dtp 3dtp 4p7h 4p7h 4pa0 4pa0 4xa1 4xa1 4xa3 4xa4 4xa6

45 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MYH7_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–1137； UniProt 2–1138 Author chain B； PDBConstruct 1–1137； UniProt 2–1138

Myosin light chain 1/3, skeletal muscle isoform

OrganismNot specified

UniProt P05977

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Myosin-7 × 2 （P12883） Myosin regulatory light chain 11 × 2 （P97457） MAGNESIUM ION × 4 ADENOSINE-5'-DIPHOSPHATE × 2 PHOSPHATE ION × 2 Mavacamten × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
7qio 7qio

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7nep 8efd 8efe 9gz1 9yop 9yp4 9yp9 9yr7 9yrg 9yrh

10 assemblies

View Construct and Data Evidence
UniProt name MYL1_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 1–187； UniProt 2–188 Author chain E； PDBConstruct 1–187； UniProt 2–188

Myosin regulatory light chain 11

OrganismNot specified

UniProt P97457

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Myosin-7 × 2 （P12883） Myosin light chain 1/3, skeletal muscle isoform × 2 （P05977） MAGNESIUM ION × 4 ADENOSINE-5'-DIPHOSPHATE × 2 PHOSPHATE ION × 2 Mavacamten × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
7qio 7qio

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7nep 9gz1 9yop 9yp4 9yp9 9yr7 9yrg 9yrh

8 assemblies

View Construct and Data Evidence
UniProt name MYL11_MOUSE
Isoform —
PDB entities 3
Chains and sequence ranges Author chain D； PDBConstruct 1–168； UniProt 2–169 Author chain F； PDBConstruct 1–168； UniProt 2–169

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9gz1
Deposition date deposition_date2024-10-03
Structure title titleBeta-cardiac myosin interacting heads motif complexed to mavacamten
Keywords keywordsMavacamten, Inhibitor, Interacting heads motif, myosin, MOTOR PROTEIN; MOTOR PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9gz1__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9gz1__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9gz1__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）52.53 Å
Rg (electron density)52.54 Å
Total Rg52.66 Å
Atom count19295
Residues2383
Excluded volume344240 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9gz1__assembly_1__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (7)

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7. Citations (1)