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9yr7

Cryo-EM structure of human beta-cardiac myosin bound to mavacamten in the interacting-heads motif and S2-FH undocked state

Method: ELECTRON MICROSCOPY Dmax: 183.7 Å Quality: GOOD

SAXS Profile

SAXS profile for 9yr7

P(r) Distribution

P(r) distribution for 9yr7
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1. Structure Basics

entry_id9yr7
deposition_date2025-10-16
titleCryo-EM structure of human beta-cardiac myosin bound to mavacamten in the interacting-heads motif and S2-FH undocked state
keywordsCardiac Myosin, Interacting Heads Motif, Mavacamten, Actin Binding, CONTRACTILE PROTEIN; CONTRACTILE PROTEIN
methodELECTRON MICROSCOPY
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Download Data

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2. SAXS Parameters (CRYSOL)

rg_guinier53.59 Å
rg_electron53.69 Å
i01134220000.00
molecular_weight281900.0 kDa
excluded_volume353390 ų
envelope_volume534260 ų
shell_volume84392 ų
envelope_diameter180.7 Å
shell_rg55.03 Å
envelope_rg52.32 Å
shape_rg53.67 Å
total_rg53.78 Å
total_atoms19808
n_residues2454
n_harmonics20
q_range— – 0.5000 Å−1
n_points101
shell_typedirectional
solvent_density0.3340 e/ų
contrast_shell0.0300 e/ų
crysol_version4.1.3
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3. P(r) Analysis (GNOM)

dmax183.7 Å
rg_real53.57 Å
rg_real_error1.92 Å
i0_real1.1340e+09
i0_real_error2.2520e+07
rg_reciprocal53.58 Å
i0_reciprocal1134000000.0000
total_estimate0.8917
solution_quality GOOD a GOOD solution
n_peaks0
r_peak_primary— Å
skewness0.227
kurtosis-0.589
angular_range— – 0.1450 Å−1
current_alpha0.0000
highest_alpha84700000.0000
n_real_points30
gnom_version4.1.3
quality_criteria AN1: 0.000; Oscil: 0.892; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.998; Smooth: 0.915
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4. Crystallography & Experiment

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5. Entities & Polymer Info (6)

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6. Citations (1)

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7. Files & Curves (10)