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9yop

Cryo-EM structure of human beta-cardiac myosin in the interacting-heads motif and S2-FH docked state

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Myosin-7,General control transcription factor GCN4,Enhanced Green fluorescent protein

Aequorea victoria

UniProt P03069

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 6 Myosin light chain 1/3, skeletal muscle isoform × 2 （P05977） Myosin regulatory light chain 11 × 2 （P97457） ADENOSINE-5'-DIPHOSPHATE × 2 PHOSPHATE ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1zta 2ovn

2 assemblies

Homodimer
1ce9 1ce9 1fmh 1kql 1nkn 1nkn 1tmz 1zii 1zik 1zil 2ahp 2zta

35 assemblies; showing the first 12

Homotetramer
1ce9 1gcl 1kql 1unt 1unu 1unv 1unw 1unx 1uny 1unz 1uo0 1uo1

37 assemblies; showing the first 12

Other homooligomers
1gcm 1ij0 1ij1 1ij2 1ij3 1piq 1rb4 1rb5 1rb6 1swi 1zij 1zim

38 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
1dgc 1fav 1gk6 1gzl 1gzl 1ihq 1ld4 1ld4 1ld4 1ld4 1ld4 1llm

89 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GCN4_YEAST
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1017–1048； UniProt 250–281 Author chain B； PDBConstruct 1017–1048； UniProt 250–281

Myosin-7,General control transcription factor GCN4,Enhanced Green fluorescent protein

Aequorea victoria

UniProt P12883

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 6 Myosin light chain 1/3, skeletal muscle isoform × 2 （P05977） Myosin regulatory light chain 11 × 2 （P97457） ADENOSINE-5'-DIPHOSPHATE × 2 PHOSPHATE ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4db1 4db1 9gz2 9gz3 9htf 9htg 9i8p

7 assemblies

Homodimer
2fxm 2fxo 2fxo 4db1

4 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3dtp 3dtp 3dtp 4p7h 4p7h 4pa0 4pa0 4xa1 4xa1 4xa3 4xa4 4xa6

45 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MYH7_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–1016； UniProt 1–1016 Author chain B； PDBConstruct 1–1016； UniProt 1–1016

Myosin-7,General control transcription factor GCN4,Enhanced Green fluorescent protein

Aequorea victoria

UniProt P42212

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 6 Myosin light chain 1/3, skeletal muscle isoform × 2 （P05977） Myosin regulatory light chain 11 × 2 （P97457） ADENOSINE-5'-DIPHOSPHATE × 2 PHOSPHATE ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1bfp 1c4f 1cv7 1ema 1emb 1emg 1f09 1f0b 1gfl 1gfl 1h6r 1h6r

379 assemblies; showing the first 12

Homodimer
1eme 1emf 1emk 1eml 1emm 1kp5 1kp5 1kp5 1myw 2b3q 2b3q 2emd

31 assemblies; showing the first 12

Homotetramer
1b9c 1emc 1hcj 1hcj 1kp5 1kp5 1w7s 1w7t 2ah8 5mse

10 assemblies

Other homooligomers
1w7u 5hbd 5hge 5hw9 6as9 6mdr

6 assemblies

Heteromeric or nucleic-acid complex
2jad 3ek4 3ek7 3ek8 3ekh 3ekj 3evr 3evu 3evv 3g9a 3k1k 3k1k

319 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GFP_AEQVI
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1055–1292； UniProt 1–238 Author chain B； PDBConstruct 1055–1292； UniProt 1–238

Myosin light chain 1/3, skeletal muscle isoform

OrganismNot specified

UniProt P05977

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 6 Myosin-7,General control transcription factor GCN4,Enhanced Green fluorescent protein × 2 （P03069,P12883,P42212） Myosin regulatory light chain 11 × 2 （P97457） ADENOSINE-5'-DIPHOSPHATE × 2 PHOSPHATE ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
7qio 7qio

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7nep 8efd 8efe 9gz1 9yop 9yp4 9yp9 9yr7 9yrg 9yrh

10 assemblies

View Construct and Data Evidence
UniProt name MYL1_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 1–188； UniProt 1–188 Author chain D； PDBConstruct 1–188； UniProt 1–188

Myosin regulatory light chain 11

OrganismNot specified

UniProt P97457

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 6 Myosin-7,General control transcription factor GCN4,Enhanced Green fluorescent protein × 2 （P03069,P12883,P42212） Myosin light chain 1/3, skeletal muscle isoform × 2 （P05977） ADENOSINE-5'-DIPHOSPHATE × 2 PHOSPHATE ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
7qio 7qio

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7nep 9gz1 9yop 9yp4 9yp9 9yr7 9yrg 9yrh

8 assemblies

View Construct and Data Evidence
UniProt name MYL11_MOUSE
Isoform —
PDB entities 3
Chains and sequence ranges Author chain E； PDBConstruct 1–169； UniProt 1–169 Author chain F； PDBConstruct 1–169； UniProt 1–169

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9yop
Deposition date deposition_date2025-10-13
Structure title titleCryo-EM structure of human beta-cardiac myosin in the interacting-heads motif and S2-FH docked state
Keywords keywordsCardiac Myosin, Interacting Heads Motif, Contractile Protein, Actin Binding; CONTRACTILE PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9yop__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9yop__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9yop__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）53.53 Å
Rg (electron density)53.65 Å
Total Rg53.74 Å
Atom count19465
Residues2411
Excluded volume347390 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9yop__assembly_1__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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7. Citations (1)